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389 results on '"Zuidema J"'

53. Thiolated recombinant human tumor necrosis factor-Alpha protects against Plasmodium berghei K173-induced experimental cerebral malaria in mice

Author

Postma, N.S., Hermsen, C.C., Crommelin, D.J.A., Eling, W.M.C., and Zuidema, J.

Subjects
gastheer-parasiet interactie [Malaria], parasite-host interaction [Malaria]
Abstract

Item does not contain fulltext 'The introduction of reactive thiol groups in recombinant human tumor necrosis factor (TNF) alpha (rhTNF-alpha) by the reagent succinimidyl-S-acetylthioacetate resulted in the formation of a chemically stabilized rhTNF-alpha trimer (rhTNFalpha-AT; as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis imental murine cerebral malaria (ECM) after itnravenous injection compared to the protective efficacy of nonmodified rhTNF-alpha. Administration of thiolated rhTNF-alpha with protected thiol groups (rhTNFalpha-ATA; no stabilized trimer in vitro) exhibited the same protective efficacy against ECM, while in vitro bioactivity was reduced. Parasitemia was significantly suppressed in rhTNF-treated mice that were protected against ECM but not in treated mice that developed ECM. Protection against ECM was not related to increased concentrations in plasma of soluble TNF receptor 1 and 2 directly after injection or at the moment of development of ECM in nontreated mice. The results indicate that thiolation of rhTNF-alpha leads to the formation of stable trimers with increased potential in vivo.

Published
1999

58. Oxydative stress in malaria: implications for prevention and therapy

Author

Postma, N.S., Mommers, E.C., Eling, W.M.C., and Zuidema, J.

Subjects
gastheer-parasiet interactie [Malaria], parasite-host interaction [Malaria], GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 22671___.PDF (Publisher’s version ) (Open Access)

Published
1996

59. Modelling of flow phenomena during DC casting

Author

Zuidema, J. (author) and Zuidema, J. (author)

Abstract

Modelling of Flow Phenomena during DC Casting Jan Zuidema The production of aluminium ingots, by semi-continuous casting, is a complex process. DC Casting stands for direct chill casting. During this process liquid aluminium transforms to solid aluminium while cooling down. This is not an instantaneous transformation, but occurs in temperature interval. In the casting process the latent heat is moved away by convection and conduction. A number of problems may occur during solidification, because the solidification rate is rather high. The difference in density between liquid and solid aluminium is 7% and because of that solidification porosities may form during solidification when transport of liquid metal is insufficient. If besides this also high enough thermal stresses are present, cracks may be induced from these pores. The cracks, that originate during the solidification of the metal are called hot cracks. This in contradiction with cold cracks. These are formed due to high stress levels in the already solidified aluminium. What happens from the moment that the casting process is started? This is one of the questions that is treated in this thesis. To be able to describe the DC Casting process, it is necessary to have a good model that describes the phenomena at hand adequately and that also enables to do predictions on process changes. The model, that is used , is based on the differential equations that describe the heat- and fluid dynamics transport. In chapter 2 a description of the model is given. Numerical methods for solving these equations are also given there. Without validation, a model is of little use. Model validation can be performed using various methods during DC Casting experiments. Temperature recordings enable to follow the evolution of the temperature during the casting- and solidification process in some important positions. Because part of the heat transport in the DC Casting process is convection driven, it is also important to find infor, Design, Engineering and Production

Published
2005

61. Als kiviet naar de Woordenlijst

Author

Neijt, A.H. and Zuidema, J.

Subjects
Taaltheorie en taaldescriptie, Linguistic theory, Algemene taalwetenschap, Filosofie en theorie van de taalwetenschap, Letteren en Geschiedenis, Linguistics, Menswetenschappen, Taal en Cultuur
Abstract

Item does not contain fulltext 8 p.

Published
1995

64. Fracture Mechanics: 2nd Edition

Author

Janssen, M. (author), Zuidema, J. (author), Wanhill, R.J.H. (author), Janssen, M. (author), Zuidema, J. (author), and Wanhill, R.J.H. (author)

Abstract

Delft University of Technology

Published
2002

76. Ingezonden

Author

Ligtenstein, D. A., Van Heust, A. N. P., Van Loenen, A. C., Beysens, A. J., and Zuidema, J.

Published
1980
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77. Abstracts of papers

Author

de Boer, A. G., Feijen, C. J., Breimer, D. D., de Haan, P., Lerk, C. F., Pieters, F. A. J. M., Merkus, F. W. H. M., Zuidema, J., Titulaer, H. A. C., Schoonen, A. J. M., de Vries-Nijboer, G. W., Coenegracht, P. M. J., Hasper, H., de Smidt, J. H., Offringa, J. C. A., Rutgers, A. A. L., Crommelin, D. J. A., Tukker, J. J., Schurgers, N., Hachmang, A. M. H., v.d. Wouw, P. A., v. Rooy, H. H., Koster, R. M., and Porsius, A. J.

Published
1985
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80. Van orthographie naar ortografie

Author

Neijt, A., Roggema, I., Zuidema, J., Neijt, A.H., Neijt, A., Roggema, I., Zuidema, J., and Neijt, A.H.

Abstract

Item does not contain fulltext

Published
1994

81. De Spellingcommissie aan het woord

Author

Neijt, A., Roggema, I., Zuidema, J., Zuidema, J.J., Neijt, A.H., Neijt, A., Roggema, I., Zuidema, J., Zuidema, J.J., and Neijt, A.H.

Abstract

Item does not contain fulltext

Published
1994

82. A simple and sensitive assay for the nitric oxide metabolites nitrite and nitrate in serum, bronchoalveolar lavage and culture media

Author

TOX, van Amsterdam JGC, Piet JJ, Zuidema J, Bisschop A, Wemer J, TOX, van Amsterdam JGC, Piet JJ, Zuidema J, Bisschop A, and Wemer J

Abstract

RIVM rapport:NO (Stikstof mono-oxide) wordt door het NO-synthase uit L-arginine vrijgezet en vertegenwoordigt een belangrijke intra- en intercellulaire boodschapperfunctie. Binnen biologische systemen wordt het NO snel naar nitriet en nitraat geoxideerd. Het totale nitriet is te beschouwen als parameter voor NO-synthase activiteit en wordt gekwantificeerd met behulp van de lichtabsorbtie van het Griess-chromofoor bij 420 nm na reductie van nitraat naar nitriet met Klebsiella pneumoniae (BBD 900.990). Met deze methode kunnen secundaire NO-synthase producten op reproduceerbare wijze in sera en andere eiwitbevattende media, zoals bronchoalveolaire wasvloeistoffen en gekleurde kweekmedia met een detectielimiet van 0,3 muM bepaald worden., NO (nitric mono-oxide) released from L-arginine by NO-synthase represents an important intra- and intercellular messenger. Within biological systems NO is rapidly oxidized to nitrite and nitrate. Total nitrite regarded as parameter for NO-synthase activity is quantified using absorbance of the Griess chromophore at 420 nm after deproteination and reduction of nitrate to nitrite using Klebsiella pneumoniae (BBD 900.990). This method allows reproducible assay of secundary NO-synthase products in sera and other protein containing media like bronchoalveolar lavages and coloured culture media with a detection limit of 0.3 muM.

Published
1994

83. De Elektronische Woordenlijst (EWL)

Author

Neijt, A., Roggema, I., Zuidema, J., Nunn, A.M., Neijt, A., Roggema, I., Zuidema, J., and Nunn, A.M.

Abstract

Item does not contain fulltext

Published
1994

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