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315 results on '"Zhu, Shida"'

52. Genetic characteristics of human papillomavirus type 16, 18, 52 and 58 in southern China

Author

Zu, Yuee, primary, Ou, Zhihua, additional, Wu, Dan, additional, Liu, Wei, additional, Liu, Liwen, additional, Wu, Di, additional, Zhao, Yanping, additional, Ren, Peidi, additional, Zhang, Yanqing, additional, Li, Wangsheng, additional, Fu, Shujin, additional, Wen, Yongchun, additional, Cai, Xianchu, additional, Liao, Wenbo, additional, Geng, Chunyu, additional, Zhou, Hongcheng, additional, Wang, Xiaman, additional, Lu, Haorong, additional, Peng, Huanhuan, additional, Liu, Na, additional, Zhu, Shida, additional, Liu, Jiyang, additional, Wang, Dongbo, additional, and Li, Junhua, additional

Published
2021
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53. Genome sequencing of 320 Chinese children with epilepsy: a clinical and molecular study

Author

Zou, Dongfang, primary, Wang, Lin, additional, Liao, Jianxiang, additional, Xiao, Hongdou, additional, Duan, Jing, additional, Zhang, Tongda, additional, Li, Jianbiao, additional, Yin, Zhenzhen, additional, Zhou, Jing, additional, Yan, Haisheng, additional, Huang, Yushan, additional, Zhan, Nianji, additional, Yang, Ying, additional, Ye, Jingyu, additional, Chen, Fang, additional, Zhu, Shida, additional, Wen, Feiqiu, additional, and Guo, Jian, additional

Published
2021
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56. Characterization of genomic clones by targeted deep sequencing of ctDNA to monitor liver cancer

Author

Sun, Yan, Kong, Xiaoyu, Yu, Jing, Zheng, Xiaolin, Lin, Mufei, Cheng, Zhengyu, Wang, Hui, An, Na, Xie, Ying, Zeng, Shuang, Xue, Siming, Xia, Min, Wei, Xia, Song, Lijie, Liu, Fengxia, Fan, Chunna, Fang, Zhonghai, Gao, Liangjun, Yang, Yun, Zhu, Shida, Shi, Taiping, Sun, Yan, Kong, Xiaoyu, Yu, Jing, Zheng, Xiaolin, Lin, Mufei, Cheng, Zhengyu, Wang, Hui, An, Na, Xie, Ying, Zeng, Shuang, Xue, Siming, Xia, Min, Wei, Xia, Song, Lijie, Liu, Fengxia, Fan, Chunna, Fang, Zhonghai, Gao, Liangjun, Yang, Yun, Zhu, Shida, and Shi, Taiping

Abstract

Background: In recent years, the morbidity and mortality of cancer patients have continued to increase in China, and there is an urgent need to develop an effective method to monitor tumor dynamics and measure tumor burden. Derived from the cell-free fraction of blood in cancer patients, circulating tumor DNA (ctDNA) has been regarded as a promising surrogate for tumor tissue biopsies. With the development of sequencing technology, ctDNA has been recognized as a specific and highly sensitive biomarker, and it has become a hot research spot in recent years. Methods: In this paper, we investigated clonal changes before and after surgery in liver cancer patients using ctDNA. Results: First, we evaluated the accuracy and stability of the method in ctDNA detection using virtual tumor samples with known mutations. The results showed that our method detected variants with an allelic frequency of at least 0.5%. We then applied this method to 34 liver cancer patients. A total of 266 clinically relevant mutations were identified in the pretreatment plasma samples. Through the analysis of plasma DNA samples at different treatment time points, we also investigated the possibility of using ctDNA as a prognostic factor to reflect tumor dynamics and to evaluate clinical responses. Conclusions: The results demonstrated that targeted high-depth next-generation sequencing can be used in ctDNA detection. Compared to traditional biopsy, the detection of ctDNA provides more information for human liver cancer, which is essential to guide the selection of therapy and predict prognosis.

Published
2021

57. Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2

Author

Wang, Daxi, Wang, Yanqun, Sun, Wanying, Zhang, Lu, Ji, Jingkai, Zhang, Zhaoyong, Cheng, Xinyi, Li, Yimin, Xiao, Fei, Zhu, Airu, Zhong, Bei, Ruan, Shicong, Li, Jiandong, Ren, Peidi, Ou, Zhihua, Xiao, Minfeng, Li, Min, Deng, Ziqing, Zhong, Huanzi, Li, Fuqiang, Wang, Wen-jing, Zhang, Yongwei, Chen, Weijun, Zhu, Shida, Xu, Xun, Jin, Xin, Zhao, Jingxian, Zhong, Nanshan, Zhang, Wenwei, Zhao, Jincun, Li, Junhua, Xu, Yonghao, Wang, Daxi, Wang, Yanqun, Sun, Wanying, Zhang, Lu, Ji, Jingkai, Zhang, Zhaoyong, Cheng, Xinyi, Li, Yimin, Xiao, Fei, Zhu, Airu, Zhong, Bei, Ruan, Shicong, Li, Jiandong, Ren, Peidi, Ou, Zhihua, Xiao, Minfeng, Li, Min, Deng, Ziqing, Zhong, Huanzi, Li, Fuqiang, Wang, Wen-jing, Zhang, Yongwei, Chen, Weijun, Zhu, Shida, Xu, Xun, Jin, Xin, Zhao, Jingxian, Zhong, Nanshan, Zhang, Wenwei, Zhao, Jincun, Li, Junhua, and Xu, Yonghao

Abstract

The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.

Published
2021

58. Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome

Author

Liu, Xiaomin, primary, Tong, Xin, additional, Zhu, Jie, additional, Tian, Liu, additional, Jie, Zhuye, additional, Zou, Yuanqiang, additional, Lin, Xiaoqian, additional, Liang, Hewei, additional, Li, Wenxi, additional, Ju, Yanmei, additional, Qin, Youwen, additional, Zou, Leying, additional, Lu, Haorong, additional, Xu, Xun, additional, Yang, Huanming, additional, Wang, Jian, additional, Zong, Yang, additional, Liu, Weibin, additional, Hou, Yong, additional, Zhu, Shida, additional, Jin, Xin, additional, Jia, Huijue, additional, and Zhang, Tao, additional

Published
2021
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59. The application of a testing platform in high-throughput nucleic acid detection of SARS-CoV-2

Author

Chen Liu, Biao Huang, Rongfang Zhou, wu hao, Ming Qiao, Chen Chen, zhang wei, dong jie, zhu shida, Jin Huang, and Zhijian Tian

Abstract

Background. The coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This coronavirus disease has spread globally as a pandemic. Quantitative reverse transcription PCR (qRT-PCR) is established as a diagnostic assay to detect SARS-CoV-2 in patient specimens. The increasing numbers of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great challenges for the test laboratories.Methods. The test specimens were collected by the hospitals or CDC in Hubei province. Viral RNA is extracted by manual column extraction and automated magnetic bead extraction method by MGISP-960 automated sample preparation system. qRT-PCR for the novel coronavirus is used in this process and several approaches were applied to prevent contamination and monitor process quality.Results. We introduced a high-throughput nucleic acid detection mode, Huo-Yan Laboratory, which has an automated process and rigorous quality control measures to ensure the stability and reliability of detection in large-scale specimens. The automated extraction method based on MGISP-960 sample preparation system has comparable results of manual extraction, and requires less time and personnel. The quality control monitoring results suggests that the quality control approaches in testing large-scale specimens are effective, and the test results are stable and reliable. Huo-Yan Laboratory mode can be flexibly adapted to the requirement of different throughput which is contributed to epidemic control in various places.

Published
2020

60. Effect of large-scale testing platform in prevention and control of the COVID-19 pandemic: an empirical study with a novel numerical model

Author

xie qing, wang jing, you jianling, zhu shida, zhou rui, tian zhijian, wu hao, lin yang, chen wei, xiao lan, li jianjuan, dong jie, wu honglong, zhang wei, li jing, xu xun, yin ye, mu feng, chen weijun, and wang jian

Abstract

A large-scale (>20,000 tests per day) standardized and fully-automated laboratory (Huo-Yan) was built as an ad-hoc measure to meet the requirement of virus detection after the novel coronavirus (COVID-19) outbreak in Wuhan, China. We integrated the brief data from Health Commission of Hubei Province and the real-world operation data of Huo-Yan laboratory, into a novel differential model with non-linear transfer coefficients and competitive compartments, to evaluate the trend of suspected cases under different nucleic acid testing capacities, including suspected cases with/without coronavirus infection, to evaluate the achievement of “daily settlement” condition of suspected cases and the control of the epidemic under different nucleic acid testing capacities.

Published
2020

61. High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

Author

Zhang, Yiqun, Chen, Fengju, Fonseca, Nuno A., He, Yao, Fujita, Masashi, Nakagawa, Hidewaki, Zhang, Zemin, Brazma, Alvis, Creighton, Chad J., Amin, Samirkumar B., Awadalla, Philip, Bailey, Peter J., Brooks, Angela N., Calabrese, Claudia, Chateigner, Aurélien, Cortés-Ciriano, Isidro, Craft, Brian, Craft, David, Davidson, Natalie R., Demircioğlu, Deniz, Erkek, Serap, Frenkel-Morgenstern, Milana, Goldman, Mary J., Greger, Liliana, Göke, Jonathan, Hoadley, Katherine A., Hou, Yong, Huska, Matthew R., Kahles, Andre, Khurana, Ekta, Kilpinen, Helena, Korbel, Jan O., Lamaze, Fabien C., Lehmann, Kjong-Van, Li, Chang, Li, Siliang, Li, Xiaobo, Li, Xinyue, Liu, Dongbing, Liu, Fenglin, Liu, Xingmin, Marin, Maximillian G., Markowski, Julia, Meyerson, Matthew, Nandi, Tannistha, Nielsen, Morten Muhlig, Ojesina, Akinyemi I., Ouellette, B. F. Francis, Pan-Hammarström, Qiang, Park, Peter J., Pedamallu, Chandra Sekhar, Pedersen, Jakob Skou, Perry, Marc D., Rätsch, Gunnar, Schwarz, Roland F., Shiraishi, Yuichi, Siebert, Reiner, Soulette, Cameron M., Stark, Stefan G., Stegle, Oliver, Su, Hong, Tan, Patrick, Teh, Bin Tean, Urban, Lara, Wang, Jian, Waszak, Sebastian M., Wu, Kui, Xiang, Qian, Xiong, Heng, Yakneen, Sergei, Yang, Huanming, Ye, Chen, Yung, Christina K., Zhang, Fan, Zhang, Junjun, Zhang, Xiuqing, Zheng, Liangtao, Zhu, Jingchun, Zhu, Shida, Akdemir, Kadir C., Alvarez, Eva G., Baez-Ortega, Adrian, Beroukhim, Rameen, Boutros, Paul C., Bowtell, David D. L., Brors, Benedikt, Burns, Kathleen H., Campbell, Peter J., Chan, Kin, Chen, Ken, Dueso-Barroso, Ana, Dunford, Andrew J., Edwards, Paul A., Estivill, Xavier, Etemadmoghadam, Dariush, Feuerbach, Lars, Fink, J. Lynn, Garsed, Dale W., Gerstein, Mark, Gordenin, Dmitry A., Haan, David, Haber, James E., Hess, Julian M., Hutter, Barbara, Imielinski, Marcin, Jones, David T. W., Ju, Young Seok, Kazanov, Marat D., Klimczak, Leszek J., Koh, Youngil, Kumar, Kiran, Lee, Eunjung Alice, Lee, Jake June-Koo, Li, Yilong, Lynch, Andy G., Macintyre, Geoff, Markowetz, Florian, Martincorena, Iñigo, Martinez-Fundichely, Alexander, Miyano, Satoru, Navarro, Fabio C. P., Ossowski, Stephan, Pearson, John V., Puiggròs, Montserrat, Rippe, Karsten, Roberts, Nicola D., Roberts, Steven A., Rodriguez-Martin, Bernardo, Schumacher, Steven E., Scully, Ralph, Shackleton, Mark, Sidiropoulos, Nikos, Sieverling, Lina, Stewart, Chip, Torrents, David, Tubio, Jose M. C., Villasante, Izar, Waddell, Nicola, Wala, Jeremiah A., Weischenfeldt, Joachim, Yang, Lixing, Yao, Xiaotong, Yoon, Sung-Soo, Zamora, Jorge, and Zhang, Cheng-Zhong

Abstract

The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common set of 1220 cancer cases, we report hundreds of genes for which the presence within 100 kb of an SV breakpoint associates with altered expression. For the majority of these genes, expression increases rather than decreases with corresponding breakpoint events. Up-regulated cancer-associated genes impacted by this phenomenon include TERT, MDM2, CDK4, ERBB2, CD274, PDCD1LG2, and IGF2. TERT-associated breakpoints involve ~3% of cases, most frequently in liver biliary, melanoma, sarcoma, stomach, and kidney cancers. SVs associated with up-regulation of PD1 and PDL1 genes involve ~1% of non-amplified cases. For many genes, SVs are significantly associated with increased numbers or greater proximity of enhancer regulatory elements near the gene. DNA methylation near the promoter is often increased with nearby SV breakpoint, which may involve inactivation of repressor elements.

Published
2020

62. Additional file 2 of Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples

Author

Minfeng Xiao, Xiaoqing Liu, Jingkai Ji, Li, Min, Jiandong Li, Yang, Lin, Wanying Sun, Peidi Ren, Guifang Yang, Jincun Zhao, Tianzhu Liang, Huahui Ren, Chen, Tian, Huanzi Zhong, Wenchen Song, Yanqun Wang, Ziqing Deng, Yanping Zhao, Zhihua Ou, Daxi Wang, Jielun Cai, Xinyi Cheng, Taiqing Feng, Honglong Wu, Yanping Gong, Huanming Yang, Wang, Jian, Xu, Xun, Zhu, Shida, Chen, Fang, Yanyan Zhang, Weijun Chen, Yimin Li, and Li, Junhua

Abstract

Additional file 2: Fig. S1. Normalized coverage across SARS-CoV-2 genomes of serial dilutions of the cultured isolate sequenced by multiple approaches. Fig. S2. Sanger sequencing results of SNVs in clinical samples. Fig. S3. Box-plot of allele frequencies against SARS-CoV-2 genome copies per mL. Fig. S4. Taxonomy of clinical samples by unbiased metatranscriptomic sequencing. Table S2. Capture sequencing data summary of serial dilutions of the cultured isolate and eight SARS-CoV-2 positive clinical samples collected from Guangzhou (PE100). Table S3. Amplicon sequencing data summary of serial dilutions of the cultured isolate and eight SARS-CoV-2 positive clinical samples collected from Guangzhou (SE400). Table S4. Estimated minimum amount of sequencing data required to achieve ≥10X sequencing depth and ≥ 95% coverage for different methods. Table S5. Estimated minimum amount of sequencing data required to achieve high-confidence variants calling analyses for different methods. Table S6. Bioinformatic tools and parameters used in this study.

Published
2020
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63. Pan-cancer analysis of whole genomes

Author

Campbell, Peter J., Getz, Gad, Korbel, Jan O., Stuart, Joshua M., Jennings, Jennifer L., Stein, Lincoln D., Perry, Marc D., Nahal-Bose, Hardeep K., Ouellette, B. F. Francis, Li, Constance H., Rheinbay, Esther, Nielsen, G. Petur, Sgroi, Dennis C., Wu, Chin-Lee, Faquin, William C., Deshpande, Vikram, Boutros, Paul C., Lazar, Alexander J., Hoadley, Katherine A., Louis, David N., Dursi, L. Jonathan, Yung, Christina K., Bailey, Matthew H., Saksena, Gordon, Raine, Keiran M., Buchhalter, Ivo, Kleinheinz, Kortine, Schlesner, Matthias, Zhang, Junjun, Wang, Wenyi, Wheeler, David A., Ding, Li, Simpson, Jared T., O'Connor, Brian D., Yakneen, Sergei, Ellrott, Kyle, Miyoshi, Naoki, Butler, Adam P., Royo, Romina, Shorser, Solomon, I, Vazquez, Miguel, Rausch, Tobias, Tiao, Grace, Waszak, Sebastian M., Rodriguez-Martin, Bernardo, Shringarpure, Suyash, Wu, Dai-Ying, Demidov, German M., Delaneau, Olivier, Hayashi, Shuto, Imoto, Seiya, Habermann, Nina, Segre, Ayellet, V, Garrison, Erik, Cafferkey, Andy, Alvarez, Eva G., Maria Heredia-Genestar, Jose, Muyas, Francesc, Drechsel, Oliver, Bruzos, Alicia L., Temes, Javier, Zamora, Jorge, Baez-Ortega, Adrian, Kim, Hyung-Lae, Mashl, R. Jay, Ye, Kai, DiBiase, Anthony, Huang, Kuan-lin, Letunic, Ivica, McLellan, Michael D., Newhouse, Steven J., Shmaya, Tal, Kumar, Sushant, Wedge, David C., Wright, Mark H., Yellapantula, Venkata D., Gerstein, Mark, Khurana, Ekta, Marques-Bonet, Tomas, Navarro, Arcadi, Bustamante, Carlos D., Siebert, Reiner, Nakagawa, Hidewaki, Easton, Douglas F., Ossowski, Stephan, Tubio, Jose M. C., De La Vega, Francisco M., Estivill, Xavier, Yuen, Denis, Mihaiescu, George L., Omberg, Larsson, Ferretti, Vincent, Sabarinathan, Radhakrishnan, Pich, Oriol, Gonzalez-Perez, Abel, Weiner, Amaro Taylor, Fittall, Matthew W., Demeulemeester, Jonas, Tarabichi, Maxime, Roberts, Nicola D., Van Loo, Peter, Cortes-Ciriano, Isidro, Urban, Lara, Park, Peter, Pitkaenen, Esa, Li, Yilong, Saini, Natalie, Klimczak, Leszek J., Weischenfeldt, Joachim, Sidiropoulos, Nikos, Alexandrov, Ludmil B., Rabionet, Raquel, Escaramis, Georgia, Bosio, Mattia, Holik, Aliaksei Z., Susak, Hana, Prasad, Aparna, Erkek, Serap, Calabrese, Claudia, Raeder, Benjamin, Harrington, Eoghan, Mayes, Simon, Turner, Daniel, Juul, Sissel, Roberts, Steven A., Song, Lei, Koster, Roelof, Mirabello, Lisa, Hua, Xing, Tanskanen, Tomas J., Tojo, Marta, Chen, Jieming, Aaltonen, Lauri A., Ratsch, Gunnar, Schwarz, Roland F., Butte, Atul J., Brazma, Alvis, Chanock, Stephen J., Chatterjee, Nilanjan, Stegle, Oliver, Harismendy, Olivier, Bova, G. Steven, Gordenin, Dmitry A., Haan, David, Sieverling, Lina, Feuerbach, Lars, Chalmers, Don, Joly, Yann, Knoppers, Bartha, Molnar-Gabor, Fruzsina, Phillips, Mark, Thorogood, Adrian, Townend, David, Goldman, Mary, Fonseca, Nuno A., Xiang, Qian, Craft, Brian, Pineiro-Yanez, Elena, Munoz, Alfonso, Petryszak, Robert, Fullgrabe, Anja, Al-Shahrour, Fatima, Keays, Maria, Haussler, David, Weinstein, John, Huber, Wolfgang, Valencia, Alfonso, Papatheodorou, Irene, Zhu, Jingchun, Fan, Yu, Torrents, David, Bieg, Matthias, Chen, Ken, Chong, Zechen, Cibulskis, Kristian, Eils, Roland, Fulton, Robert S., Gelpi, Josep L., Gonzalez, Santiago, Gut, Ivo G., Hach, Faraz, Heinold, Michael, Hu, Taobo, Huang, Vincent, Hutter, Barbara, Jaeger, Natalie, Jung, Jongsun, Kumar, Yogesh, Lalansingh, Christopher, Leshchiner, Ignaty, Livitz, Dimitri, Ma, Eric Z., Maruvka, Yosef E., Milovanovic, Ana, Nielsen, Morten Muhlig, Paramasivam, Nagarajan, Pedersen, Jakob Skou, Puiggros, Montserrat, Sahinalp, S. Cenk, Sarrafi, Iman, Stewart, Chip, Stobbe, Miranda D., Wala, Jeremiah A., Wang, Jiayin, Wendl, Michael, Werner, Johannes, Wu, Zhenggang, Xue, Hong, Yamaguchi, Takafumi N., Yellapantula, Venkata, Davis-Dusenbery, Brandi N., Grossman, Robert L., Kim, Youngwook, Heinold, Michael C., Hinton, Jonathan, Jones, David R., Menzies, Andrew, Stebbings, Lucy, Hess, Julian M., Rosenberg, Mara, Dunford, Andrew J., Gupta, Manaswi, Imielinski, Marcin, Meyerson, Matthew, Beroukhim, Rameen, Reimand, Juri, Dhingra, Priyanka, Favero, Francesco, Dentro, Stefan, Wintersinger, Jeff, Rudneva, Vasilisa, Park, Ji Wan, Hong, Eun Pyo, Heo, Seong Gu, Kahles, Andre, Soulette, Cameron M., Shiraishi, Yuichi, Liu, Fenglin, He, Yao, Demircioglu, Deniz, Davidson, Natalie R., Greger, Liliana, Li, Siliang, Liu, Dongbing, Stark, Stefan G., Zhang, Fan, Amin, Samirkumar B., Bailey, Peter, Chateigner, Aurelien, Frenkel-Morgenstern, Milana, Hou, Yong, Huska, Matthew R., Kilpinen, Helena, Lamaze, Fabien C., Li, Chang, Li, Xiaobo, Li, Xinyue, Liu, Xingmin, Marin, Maximillian G., Markowski, Julia, Nandi, Tannistha, Ojesina, Akinyemi, I, Pan-Hammarstrom, Qiang, Park, Peter J., Pedamallu, Chandra Sekhar, Su, Hong, Tan, Patrick, Teh, Bin Tean, Wang, Jian, Xiong, Heng, Ye, Chen, Yung, Christina, Zhang, Xiuqing, Zheng, Liangtao, Zhu, Shida, Awadalla, Philip, Creighton, Chad J., Wu, Kui, Yang, Huanming, Goke, Jonathan, Zhang, Zemin, Brooks, Angela N., Martincorena, Inigo, Rubio-Perez, Carlota, Juul, Malene, Schumacher, Steven, Shapira, Ofer, Tamborero, David, Mularoni, Loris, Hornshoj, Henrik, Deu-Pons, Jordi, Muinos, Ferran, Bertl, Johanna, Guo, Qianyun, Bazant, Wojciech, Barrera, Elisabet, Al-Sedairy, Sultan T., Aretz, Axel, Bell, Cindy, Betancourt, Miguel, Buchholz, Christiane, Calvo, Fabien, Chomienne, Christine, Dunn, Michael, Edmonds, Stuart, Green, Eric, Gupta, Shailja, Hutter, Carolyn M., Jegalian, Karine, Jones, Nic, Lu, Youyong, Nakagama, Hitoshi, Nettekoven, Gerd, Planko, Laura, Scott, David, Shibata, Tatsuhiro, Shimizu, Kiyo, Stratton, Michael R., Yugawa, Takashi, Tortora, Giampaolo, VijayRaghavan, K., Zenklusen, Jean C., Knoppers, Bartha M., Aminou, Brice, Bartolome, Javier, Boroevich, Keith A., Boyce, Rich, Buchanan, Alex, Byrne, Niall J., Chen, Zhaohong, Cho, Sunghoon, Choi, Wan, Clapham, Peter, Dow, Michelle T., Dursi, Lewis Jonathan, Eils, Juergen, Farcas, Claudiu, Fayzullaev, Nodirjon, Flicek, Paul, Heath, Allison P., Hofmann, Oliver, Hong, Jongwhi H., Hudson, Thomas J., Huebschmann, Daniel, Ivkovic, Sinisa, Jeon, Seung-Hyup, Jiao, Wei, Kabbe, Rolf, Kerssemakers, Jules N. A., Kim, Hyunghwan, Kim, Jihoon, Koscher, Michael, Koures, Antonios, Kovacevic, Milena, Lawerenz, Chris, Liu, Jia, Mijalkovic, Sanja, Mijalkovic-Lazic, Ana Mijalkovic, Miyano, Satoru, Nastic, Mia, Nicholson, Jonathan, Ocana, David, Ohi, Kazuhiro, Ohno-Machado, Lucila, Pihl, Todd D., Prinz, Manuel, Radovic, Petar, Short, Charles, Sofia, Heidi J., Spring, Jonathan, Struck, Adam J., Tijanic, Nebojsa, Vicente, David, Wang, Zhining, Williams, Ashley, Woo, Youngchoon, Wright, Adam J., Yang, Liming, Hamilton, Mark P., Johnson, Todd A., Kahraman, Abdullah, Kellis, Manolis, Polak, Paz, Sallari, Richard, Sinnott-Armstrong, Nasa, von Mering, Christian, Beltran, Sergi, Gerhard, Daniela S., Gut, Marta, Trotta, Jean-Remi, Whalley, Justin P., Niu, Beifang, Espiritu, Shadrielle M. G., Gao, Shengjie, Huang, Yi, Lalansingh, Christopher M., Teague, Jon W., Wendl, Michael C., Abascal, Federico, Bader, Gary D., Bandopadhayay, Pratiti, Barenboim, Jonathan, Brunak, Soren, Fita, Joana Carlevaro, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Choi, Jung Kyoon, Diamanti, Klev, Fink, J. Lynn, Frigola, Joan, Gambacorti-Passerini, Carlo, Garsed, Dale W., Haradhvala, Nicholas J., Harmanci, Arif O., Helmy, Mohamed, Herrmann, Carl, Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Isaev, Keren, Izarzugaza, Jose M. G., Johnson, Rory, Juul, Randi Istrup, Kim, Jaegil, Kim, Jong K., Komorowski, Jan, Lanzos, Andres, Larsson, Erik, Lee, Donghoon, Li, Shantao, Li, Xiaotong, Lin, Ziao, Liu, Eric Minwei, Lochovsky, Lucas, Lou, Shaoke, Madsen, Tobias, Marchal, Kathleen, Fundichely, Alexander Martinez, McGillivray, Patrick D., Meyerson, William, Paczkowska, Marta, Park, Keunchil, Park, Kiejung, Pons, Tirso, Pulido-Tamayo, Sergio, Reyes Salazar, Iker, Reyna, Matthew A., Rubin, Mark A., Salichos, Leonidas, Sander, Chris, Schumacher, Steven E., Shackleton, Mark, Shen, Ciyue, Shrestha, Raunak, Shuai, Shimin, Tsunoda, Tatsuhiko, Umer, Husen M., Uuskula-Reimand, Liis, Verbeke, Lieven P. C., Wadelius, Claes, Wadi, Lina, Warrell, Jonathan, Wu, Guanming, Yu, Jun, Zhang, Jing, Zhang, Xuanping, Zhang, Yan, Zhao, Zhongming, Zou, Lihua, Lawrence, Michael S., Raphael, Benjamin J., Bailey, Peter J., Craft, David, Goldman, Mary J., Aburatani, Hiroyuki, Binder, Hans, Dinh, Huy Q., Heath, Simon C., Hoffmann, Steve, Imbusch, Charles David, Kretzmer, Helene, Laird, Peter W., Martin-Subero, Jose, I, Nagae, Genta, Shen, Hui, Wang, Qi, Weichenhan, Dieter, Zhou, Wanding, Berman, Benjamin P., Brors, Benedikt, Plass, Christoph, Akdemir, Kadir C., Bowtell, David D. L., Burns, Kathleen H., Busanovich, John, Chan, Kin, Dueso-Barroso, Ana, Edwards, Paul A., Etemadmoghadam, Dariush, Haber, James E., Jones, David T. W., Ju, Young Seok, Kazanov, Marat D., Koh, Youngil, Kumar, Kiran, Lee, Eunjung Alice, Lee, Jake June-Koo, Lynch, Andy G., Macintyre, Geoff, Markowetz, Florian, Navarro, Fabio C. P., Pearson, John, V, Rippe, Karsten, Scully, Ralph, Villasante, Izar, Waddell, Nicola, Yang, Lixing, Yao, Xiaotong, Yoon, Sung-Soo, Zhang, Cheng-Zhong, Bergstrom, Erik N., Boot, Arnoud, Covington, Kyle, Fujimoto, Akihiro, Huang, Mi Ni, Islam, S. M. Ashiqul, McPherson, John R., Morganella, Sandro, Mustonen, Ville, Ng, Alvin Wei Tian, Prokopec, Stephenie D., Vazquez-Garcia, Ignacio, Wu, Yang, Yousif, Fouad, Yu, Willie, Rozen, Steven G., Rudneva, Vasilisa A., Shringarpure, Suyash S., Turner, Daniel J., Xia, Tian, Atwal, Gurnit, Chang, David K., Cooke, Susanna L., Faltas, Bishoy M., Haider, Syed, Kaiser, Vera B., Karlic, Rosa, Kato, Mamoru, Kubler, Kirsten, Margolin, Adam, Martin, Sancha, Nik-Zainal, Serena, P'ng, Christine, Semple, Colin A., Smith, Jaclyn, Sun, Ren X., Thai, Kevin, Wright, Derek W., Yuan, Ke, Biankin, Andrew, V, Garraway, Levi, Grimmond, Sean M., Adams, David J., Anur, Pavana, Cao, Shaolong, Christie, Elizabeth L., Cmero, Marek, Cun, Yupeng, Dawson, Kevin J., Dentro, Stefan C., Deshwar, Amit G., Donmez, Nilgun, Drews, Ruben M., Gerstung, Moritz, Ha, Gavin, Haase, Kerstin, Jerman, Lara, Ji, Yuan, Jolly, Clemency, Lee, Juhee, Lee-Six, Henry, Malikic, Salem, Mitchell, Thomas J., Morris, Quaid D., Oesper, Layla, Peifer, Martin, Peto, Myron, Rosebrock, Daniel, Rubanova, Yulia, Salcedo, Adriana, Sengupta, Subhajit, Shi, Ruian, Shin, Seung Jun, Spiro, Oliver, Vembu, Shankar, Wintersinger, Jeffrey A., Yang, Tsun-Po, Yu, Kaixian, Zhu, Hongtu, Spellman, Paul T., Weinstein, John N., Chen, Yiwen, Fujita, Masashi, Han, Leng, Hasegawa, Takanori, Komura, Mitsuhiro, Li, Jun, Mizuno, Shinichi, Shimizu, Eigo, Wang, Yumeng, Xu, Yanxun, Yamaguchi, Rui, Yang, Fan, Yang, Yang, Yoon, Christopher J., Yuan, Yuan, Liang, Han, Alawi, Malik, Borozan, Ivan, Brewer, Daniel S., Cooper, Colin S., Desai, Nikita, Grundhoff, Adam, Iskar, Murat, Su, Xiaoping, Zapatka, Marc, Lichter, Peter, Alsop, Kathryn, Bruxner, Timothy J. C., Christ, Angelika N., Cordner, Stephen M., Cowin, Prue A., Drapkin, Ronny, Fereday, Sian, George, Joshy, Hamilton, Anne, Holmes, Oliver, Hung, Jillian A., Kassahn, Karin S., Kazakoff, Stephen H., Kennedy, Catherine J., Leonard, Conrad R., Mileshkin, Linda, Miller, David K., Arnau, Gisela Mir, Mitchell, Chris, Newell, Felicity, Nones, Katia, Patch, Ann-Marie, Quinn, Michael C., Taylor, Darrin F., Thorne, Heather, Traficante, Nadia, Vedururu, Ravikiran, Waddell, Nick M., Waring, Paul M., Wood, Scott, Xu, Qinying, DeFazio, Anna, Anderson, Matthew J., Antonello, Davide, Barbour, Andrew P., Bassi, Claudio, Bersani, Samantha, Cataldo, Ivana, Chantrill, Lorraine A., Chiew, Yoke-Eng, Chou, Angela, Cingarlini, Sara, Cloonan, Nicole, Corbo, Vincenzo, Davi, Maria Vittoria, Duthie, Fraser R., Gill, Anthony J., Graham, Janet S., Harliwong, Ivon, Jamieson, Nigel B., Johns, Amber L., Kench, James G., Landoni, Luca, Lawlor, Rita T., Mafficini, Andrea, Merrett, Neil D., Miotto, Marco, Musgrove, Elizabeth A., Nagrial, Adnan M., Oien, Karin A., Pajic, Marina, Pinese, Mark, Robertson, Alan J., Rooman, Ilse, Rusev, Borislav C., Samra, Jaswinder S., Scardoni, Maria, Scarlett, Christopher J., Scarpa, Aldo, Sereni, Elisabetta, Sikora, Katarzyna O., Simbolo, Michele, Taschuk, Morgan L., Toon, Christopher W., Vicentini, Caterina, Wu, Jianmin, Zeps, Nikolajs, Behren, Andreas, Burke, Hazel, Cebon, Jonathan, Dagg, Rebecca A., De Paoli-Iseppi, Ricardo, Dutton-Regester, Ken, Field, Matthew A., Fitzgerald, Anna, Hersey, Peter, Jakrot, Valerie, Johansson, Peter A., Kakavand, Hojabr, Kefford, Richard F., Lau, Loretta M. S., Long, Georgina, V, Pickett, Hilda A., Pritchard, Antonia L., Pupo, Gulietta M., Saw, Robyn P. M., Schramm, Sarah-Jane, Shang, Catherine A., Shang, Ping, Spillane, Andrew J., Stretch, Jonathan R., Tembe, Varsha, Thompson, John F., Vilain, Ricardo E., Wilmott, James S., Yang, Jean Y., Hayward, Nicholas K., Mann, Graham J., Scolyer, Richard A., Bartlett, John, Bavi, Prashant, Chadwick, Dianne E., Chan-Seng-Yue, Michelle, Cleary, Sean, Connor, Ashton A., Czajka, Karolina, Denroche, Robert E., Dhani, Neesha C., Eagles, Jenna, Gallinger, Steven, Grant, Robert C., Hedley, David, Hollingsworth, Michael A., Jang, Gun Ho, Johns, Jeremy, Kalimuthu, Sangeetha, Liang, Sheng-Ben, Lungu, Ilinca, Luo, Xuemei, Mbabaali, Faridah, McPherson, Treasa A., Miller, Jessica K., Moore, Malcolm J., Notta, Faiyaz, Pasternack, Danielle, Petersen, Gloria M., Roehrl, Michael H. A., Sam, Michelle, Selander, Iris, Serra, Stefano, Shahabi, Sagedeh, Thayer, Sarah P., Timms, Lee E., Wilson, Gavin W., Wilson, Julie M., Wouters, Bradly G., McPherson, John D., Beck, Timothy A., Bhandari, Vinayak, Collins, Colin C., Fleshner, Neil E., Fox, Natalie S., Fraser, Michael, Heisler, Lawrence E., Lalonde, Emilie, Livingstone, Julie, Meng, Alice, Sabelnykova, Veronica Y., Shiah, Yu-Jia, Van Der Kwast, Theodorus, Bristow, Robert G., Ding, Shuai, Fan, Daiming, Li, Lin, Nie, Yongzhan, Xiao, Xiao, Xing, Rui, Yang, Shanlin, Yu, Yingyan, Zhou, Yong, Banks, Rosamonde E., Bourque, Guillaume, Brennan, Paul, Letourneau, Louis, Riazalhosseini, Yasser, Scelo, Ghislaine, Vasudev, Naveen, Viksna, Juris, Lathrop, Mark, Tost, Jorg, Ahn, Sung-Min, Aparicio, Samuel, Arnould, Laurent, Aure, M. R., Bhosle, Shriram G., Birney, Ewan, Borg, Ake, Boyault, Sandrine, Brinkman, Arie B., Brock, Jane E., Broeks, Annegien, Borresen-Dale, Anne-Lise, Caldas, Carlos, Chin, Suet-Feung, Davies, Helen, Desmedt, Christine, Dirix, Luc, Dronov, Serge, Ehinger, Anna, Eyfjord, Jorunn E., Fatima, Aquila, Foekens, John A., Futreal, P. Andrew, Garred, Oystein, Giri, Dilip D., Glodzik, Dominik, Grabau, Dorthe, Hilmarsdottir, Holmfridur, Hooijer, Gerrit K., Jacquemier, Jocelyne, Jang, Se Jin, Jonasson, Jon G., Jonkers, Jos, Kim, Hyung-Yong, King, Tari A., Knappskog, Stian, Kong, Gu, Krishnamurthy, Savitri, Lakhani, Sunil R., Langerod, Anita, Larsimont, Denis, Lee, Hee Jin, Lee, Jeong-Yeon, Lee, Ming Ta Michael, Lingjaerde, Ole Christian, MacGrogan, Gaetan, Martens, John W. M., O'Meara, Sarah, Pauporte, Iris, Pinder, Sarah, Pivot, Xavier, Provenzano, Elena, Purdie, Colin A., Ramakrishna, Manasa, Ramakrishnan, Kamna, Reis-Filho, Jorge, Richardson, Andrea L., Ringner, Markus, Rodriguez, Javier Bartolome, Rodriguez-Gonzalez, F. German, Romieu, Gilles, Salgado, Roberto, Sauer, Torill, Shepherd, Rebecca, Sieuwerts, Anieta M., Simpson, Peter T., Smid, Marcel, Sotiriou, Christos, Span, Paul N., Stefansson, Olafur Andri, Stenhouse, Alasdair, Stunnenberg, Henk G., Sweep, Fred, Tan, Benita Kiat Tee, Thomas, Gilles, Thompson, Alastair M., Tommasi, Stefania, Treilleux, Isabelle, Tutt, Andrew, Ueno, Naoto T., Van Laere, Steven, Van den Eynden, Gert G., Vermeulen, Peter, Viari, Alain, Vincent-Salomon, Anne, Wong, Bernice H., Yates, Lucy, Zou, Xueqing, van Deurzen, Carolien H. M., van de Vijver, Marc J., van't Veer, Laura, Ammerpohl, Ole, Aukema, Sietse, Bergmann, Anke K., Bernhart, Stephan H., Borkhardt, Arndt, Borst, Christoph, Burkhardt, Birgit, Claviez, Alexander, Goebler, Maria Elisabeth, Haake, Andrea, Haas, Siegfried, Hansmann, Martin, Hoell, Jessica, I, Hummel, Michael, Karsch, Dennis, Klapper, Wolfram, Kneba, Michael, Kreuz, Markus, Kube, Dieter, Kueppers, Ralf, Lenze, Dido, Loeffler, Markus, Lopez, Cristina, Mantovani-Loeffler, Luisa, Moeller, Peter, Ott, German, Radlwimmer, Bernhard, Richter, Julia, Rohde, Marius, Rosenstiel, Philip C., Rosenwald, Andreas, Schilhabel, Markus B., Schreiber, Stefan, Stadler, Peter F., Staib, Peter, Stilgenbauer, Stephan, Sungalee, Stephanie, Szczepanowski, Monika, Toprak, Umut H., Truemper, Lorenz H. P., Wagener, Rabea, Zenz, Thorsten, Hovestadt, Volker, von Kalle, Christof, Kool, Marcel, Korshunov, Andrey, Landgraf, Pablo, Lehrach, Hans, Northcott, Paul A., Pfister, Stefan M., Reifenberger, Guido, Warnatz, Hans-Joerg, Wolf, Stephan, Yaspo, Marie-Laure, Assenov, Yassen, Gerhauser, Clarissa, Minner, Sarah, Schlomm, Thorsten, Simon, Ronald, Sauter, Guido, Sueltmann, Holger, Biswas, Nidhan K., Maitra, Arindam, Majumder, Partha P., Sarin, Rajiv, Barbi, Stefano, Bonizzato, Giada, Cantu, Cinzia, Dei Tos, Angelo P., Fassan, Matteo, Grimaldi, Sonia, Luchini, Claudio, Malleo, Giuseppe, Marchegiani, Giovanni, Milella, Michele, Paiella, Salvatore, Pea, Antonio, Pederzoli, Paolo, Ruzzenente, Andrea, Salvia, Roberto, Sperandio, Nicola, Arai, Yasuhito, Hama, Natsuko, Hiraoka, Nobuyoshi, Hosoda, Fumie, Nakamura, Hiromi, Ojima, Hidenori, Okusaka, Takuji, Totoki, Yasushi, Urushidate, Tomoko, Fukayama, Masashi, Ishikawa, Shumpei, Katai, Hitoshi, Katoh, Hiroto, Komura, Daisuke, Rokutan, Hirofumi, Saito-Adachi, Mihoko, Suzuki, Akihiro, Taniguchi, Hirokazu, Tatsuno, Kenji, Ushiku, Tetsuo, Yachida, Shinichi, Yamamoto, Shogo, Aikata, Hiroshi, Arihiro, Koji, Ariizumi, Shun-ichi, Chayama, Kazuaki, Furuta, Mayuko, Gotoh, Kunihito, Hayami, Shinya, Hirano, Satoshi, Kawakami, Yoshiiku, Maejima, Kazuhiro, Nakamura, Toru, Nakano, Kaoru, Ohdan, Hideki, Sasaki-Oku, Aya, Tanaka, Hiroko, Ueno, Masaki, Yamamoto, Masakazu, Yamaue, Hiroki, Choo, Su Pin, Cutcutache, Ioana, Khuntikeo, Narong, Ong, Choon Kiat, Pairojkul, Chawalit, Popescu, Irinel, Ahn, Keun Soo, Aymerich, Marta, Lopez-Guillermo, Armando, Lopez-Otin, Carlos, Puente, Xose S., Campo, Elias, Amary, Fernanda, Baumhoer, Daniel, Behjati, Sam, Bjerkehagen, Bodil, Futreal, P. A., Myklebost, Ola, Pillay, Nischalan, Tarpey, Patrick, Tirabosco, Roberto, Zaikova, Olga, Flanagan, Adrienne M., Boultwood, Jacqueline, Bowen, David T., Cazzola, Mario, Green, Anthony R., Hellstrom-Lindberg, Eva, Malcovati, Luca, Nangalia, Jyoti, Papaemmanuil, Elli, Vyas, Paresh, Ang, Yeng, Barr, Hugh, Beardsmore, Duncan, Eldridge, Matthew, Gossage, James, Grehan, Nicola, Hanna, George B., Hayes, Stephen J., Hupp, Ted R., Khoo, David, Lagergren, Jesper, Lovat, Laurence B., MacRae, Shona, O'Donovan, Maria, O'Neill, J. Robert, Parsons, Simon L., Preston, Shaun R., Puig, Sonia, Roques, Tom, Sanders, Grant, Sothi, Sharmila, Tavare, Simon, Tucker, Olga, Turkington, Richard, Underwood, Timothy J., Welch, Ian, Fitzgerald, Rebecca C., Berney, Daniel M., De Bono, Johann S., Cahill, Declan, Camacho, Niedzica, Dennis, Nening M., Dudderidge, Tim, Edwards, Sandra E., Fisher, Cyril, Foster, Christopher S., Ghori, Mohammed, Gill, Pelvender, Gnanapragasam, Vincent J., Gundem, Gunes, Hamdy, Freddie C., Hawkins, Steve, Hazell, Steven, Howat, William, Isaacs, William B., Karaszi, Katalin, Kay, Jonathan D., Khoo, Vincent, Kote-Jarai, Zsofia, Kremeyer, Barbara, Kumar, Pardeep, Lambert, Adam, Leongamornlert, Daniel A., Livni, Naomi, Lu, Yong-Jie, Luxton, Hayley J., Marsden, Luke, Massie, Charlie E., Matthews, Lucy, Mayer, Erik, McDermott, Ultan, Merson, Sue, Neal, David E., Ng, Anthony, Nicol, David, Ogden, Christopher, Rowe, Edward W., Shah, Nimish C., Thomas, Sarah, Thompson, Alan, Verrill, Clare, Visakorpi, Tapio, Warren, Anne Y., Whitaker, Hayley C., Zhang, Hongwei, van As, Nicholas, Eeles, Rosalind A., Abeshouse, Adam, Agrawal, Nishant, Akbani, Rehan, Al Ahmadie, Hikmat, Albert, Monique, Aldape, Kenneth, Ally, Adrian, Appelbaum, Elizabeth L., Armenia, Joshua, Asa, Sylvia, Auman, J. Todd, Balasundaram, Miruna, Balu, Saianand, Barnholtz-Sloan, Jill, Bathe, Oliver F., Baylin, Stephen B., Benz, Christopher, Berchuck, Andrew, Berrios, Mario, Bigner, Darell, Birrer, Michael, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S., Bosenberg, Marcus, Bowlby, Reanne, Boyd, Jeffrey, Broaddus, Russell R., Brock, Malcolm, Brooks, Denise, Bullman, Susan, Caesar-Johnson, Samantha J., Carey, Thomas E., Carlsen, Rebecca, Cerfolio, Robert, Chandan, Vishal S., Chen, Hsiao-Wei, Cherniack, Andrew D., Chien, Jeremy, Cho, Juok, Chuah, Eric, Cibulskis, Carrie, Cope, Leslie, Cordes, Matthew G., Curley, Erin, Czerniak, Bogdan, Danilova, Ludmila, Davis, Ian J., Defreitas, Timothy, Demchok, John A., Dhalla, Noreen, Dhir, Rajiv, Doddapaneni, HarshaVardhan, El-Naggar, Adel, Felau, Ina, Ferguson, Martin L., Finocchiaro, Gaetano, Fong, Kwun M., Frazer, Scott, Friedman, William, Fronick, Catrina C., Fulton, Lucinda A., Gabriel, Stacey B., Gao, Jianjiong, Gehlenborg, Nils, Gershenwald, Jeffrey E., Ghossein, Ronald, Giama, Nasra H., Gibbs, Richard A., Gomez, Carmen, Govindan, Ramaswamy, Hayes, D. Neil, Hegde, Apurva M., Heiman, David, I, Heins, Zachary, Hepperla, Austin J., Holbrook, Andrea, Holt, Robert A., Hoyle, Alan P., Hruban, Ralph H., Hu, Jianhong, Huang, Mei, Huntsman, David, Huse, Jason, Donahue, Christine A. Iacobuzio, Ittmann, Michael, Jayaseelan, Joy C., Jefferys, Stuart R., Jones, Corbin D., Jones, Steven J. M., Juhl, Hartmut, Kang, Koo Jeong, Karlan, Beth, Kasaian, Katayoon, Kebebew, Electron, Kim, Hark Kyun, Korchina, Viktoriya, Kundra, Ritika, Lai, Phillip H., Lander, Eric, Le, Xuan, Lee, Darlene, Levine, Douglas A., Lewis, Lora, Ley, Tim, Li, Haiyan Irene, Lin, Pei, Linehan, W. M., Liu, Fei Fei, Lu, Yiling, Lype, Lisa, Ma, Yussanne, Maglinte, Dennis T., Mardis, Elaine R., Marks, Jeffrey, Marra, Marco A., Matthew, Thomas J., Mayo, Michael, McCune, Karen, Meier, Samuel R., Meng, Shaowu, Mieczkowski, Piotr A., Mikkelsen, Tom, Miller, Christopher A., Mills, Gordon B., Moore, Richard A., Morrison, Carl, Mose, Lisle E., Moser, Catherine D., Mungall, Andrew J., Mungall, Karen, Mutch, David, Muzny, Donna M., Myers, Jerome, Newton, Yulia, Noble, Michael S., O'Donnell, Peter, O'Neill, Brian Patrick, Ochoa, Angelica, Park, Joong-Won, Parker, Joel S., Pass, Harvey, Pastore, Alessandro, Pennell, Nathan A., Perou, Charles M., Petrelli, Nicholas, Potapova, Olga, Rader, Janet S., Ramalingam, Suresh, Rathmell, W. Kimryn, Reuter, Victor, Reynolds, Sheila M., Ringel, Matthew, Roach, Jeffrey, Roberts, Lewis R., Robertson, A. Gordon, Sadeghi, Sara, Saller, Charles, Sanchez-Vega, Francisco, Schadendorf, Dirk, Schein, Jacqueline E., Schmidt, Heather K., Schultz, Nikolaus, Seethala, Raja, Senbabaoglu, Yasin, Shelton, Troy, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Shriver, Craig, Signoretti, Sabina, Simons, Janae, V, Singer, Samuel, Sipahimalani, Payal, Skelly, Tara J., McCune, Karen Smith, Socci, Nicholas D., Soloway, Matthew G., Sood, Anil K., Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Thiessen, Nina, Thompson, R. Houston, Thorne, Leigh B., Tsao, Ming, Umbricht, Christopher, Van Den Berg, David J., Van Meir, Erwin G., Veluvolu, Umadevi, Voet, Douglas, Wang, Linghua, Weinberger, Paul, Weisenberger, Daniel J., Wigle, Dennis, Wilkerson, Matthew D., Wilson, Richard K., Winterhoff, Boris, Wiznerowicz, Maciej, Wong, Tina, Wong, Winghing, Xi, Liu, Yau, Christina, Zhang, Hailei, Zhang, Hongxin, Zhang, Jiashan, Campbell, Peter J., Getz, Gad, Korbel, Jan O., Stuart, Joshua M., Jennings, Jennifer L., Stein, Lincoln D., Perry, Marc D., Nahal-Bose, Hardeep K., Ouellette, B. F. Francis, Li, Constance H., Rheinbay, Esther, Nielsen, G. Petur, Sgroi, Dennis C., Wu, Chin-Lee, Faquin, William C., Deshpande, Vikram, Boutros, Paul C., Lazar, Alexander J., Hoadley, Katherine A., Louis, David N., Dursi, L. Jonathan, Yung, Christina K., Bailey, Matthew H., Saksena, Gordon, Raine, Keiran M., Buchhalter, Ivo, Kleinheinz, Kortine, Schlesner, Matthias, Zhang, Junjun, Wang, Wenyi, Wheeler, David A., Ding, Li, Simpson, Jared T., O'Connor, Brian D., Yakneen, Sergei, Ellrott, Kyle, Miyoshi, Naoki, Butler, Adam P., Royo, Romina, Shorser, Solomon, I, Vazquez, Miguel, Rausch, Tobias, Tiao, Grace, Waszak, Sebastian M., Rodriguez-Martin, Bernardo, Shringarpure, Suyash, Wu, Dai-Ying, Demidov, German M., Delaneau, Olivier, Hayashi, Shuto, Imoto, Seiya, Habermann, Nina, Segre, Ayellet, V, Garrison, Erik, Cafferkey, Andy, Alvarez, Eva G., Maria Heredia-Genestar, Jose, Muyas, Francesc, Drechsel, Oliver, Bruzos, Alicia L., Temes, Javier, Zamora, Jorge, Baez-Ortega, Adrian, Kim, Hyung-Lae, Mashl, R. Jay, Ye, Kai, DiBiase, Anthony, Huang, Kuan-lin, Letunic, Ivica, McLellan, Michael D., Newhouse, Steven J., Shmaya, Tal, Kumar, Sushant, Wedge, David C., Wright, Mark H., Yellapantula, Venkata D., Gerstein, Mark, Khurana, Ekta, Marques-Bonet, Tomas, Navarro, Arcadi, Bustamante, Carlos D., Siebert, Reiner, Nakagawa, Hidewaki, Easton, Douglas F., Ossowski, Stephan, Tubio, Jose M. C., De La Vega, Francisco M., Estivill, Xavier, Yuen, Denis, Mihaiescu, George L., Omberg, Larsson, Ferretti, Vincent, Sabarinathan, Radhakrishnan, Pich, Oriol, Gonzalez-Perez, Abel, Weiner, Amaro Taylor, Fittall, Matthew W., Demeulemeester, Jonas, Tarabichi, Maxime, Roberts, Nicola D., Van Loo, Peter, Cortes-Ciriano, Isidro, Urban, Lara, Park, Peter, Pitkaenen, Esa, Li, Yilong, Saini, Natalie, Klimczak, Leszek J., Weischenfeldt, Joachim, Sidiropoulos, Nikos, Alexandrov, Ludmil B., Rabionet, Raquel, Escaramis, Georgia, Bosio, Mattia, Holik, Aliaksei Z., Susak, Hana, Prasad, Aparna, Erkek, Serap, Calabrese, Claudia, Raeder, Benjamin, Harrington, Eoghan, Mayes, Simon, Turner, Daniel, Juul, Sissel, Roberts, Steven A., Song, Lei, Koster, Roelof, Mirabello, Lisa, Hua, Xing, Tanskanen, Tomas J., Tojo, Marta, Chen, Jieming, Aaltonen, Lauri A., Ratsch, Gunnar, Schwarz, Roland F., Butte, Atul J., Brazma, Alvis, Chanock, Stephen J., Chatterjee, Nilanjan, Stegle, Oliver, Harismendy, Olivier, Bova, G. Steven, Gordenin, Dmitry A., Haan, David, Sieverling, Lina, Feuerbach, Lars, Chalmers, Don, Joly, Yann, Knoppers, Bartha, Molnar-Gabor, Fruzsina, Phillips, Mark, Thorogood, Adrian, Townend, David, Goldman, Mary, Fonseca, Nuno A., Xiang, Qian, Craft, Brian, Pineiro-Yanez, Elena, Munoz, Alfonso, Petryszak, Robert, Fullgrabe, Anja, Al-Shahrour, Fatima, Keays, Maria, Haussler, David, Weinstein, John, Huber, Wolfgang, Valencia, Alfonso, Papatheodorou, Irene, Zhu, Jingchun, Fan, Yu, Torrents, David, Bieg, Matthias, Chen, Ken, Chong, Zechen, Cibulskis, Kristian, Eils, Roland, Fulton, Robert S., Gelpi, Josep L., Gonzalez, Santiago, Gut, Ivo G., Hach, Faraz, Heinold, Michael, Hu, Taobo, Huang, Vincent, Hutter, Barbara, Jaeger, Natalie, Jung, Jongsun, Kumar, Yogesh, Lalansingh, Christopher, Leshchiner, Ignaty, Livitz, Dimitri, Ma, Eric Z., Maruvka, Yosef E., Milovanovic, Ana, Nielsen, Morten Muhlig, Paramasivam, Nagarajan, Pedersen, Jakob Skou, Puiggros, Montserrat, Sahinalp, S. Cenk, Sarrafi, Iman, Stewart, Chip, Stobbe, Miranda D., Wala, Jeremiah A., Wang, Jiayin, Wendl, Michael, Werner, Johannes, Wu, Zhenggang, Xue, Hong, Yamaguchi, Takafumi N., Yellapantula, Venkata, Davis-Dusenbery, Brandi N., Grossman, Robert L., Kim, Youngwook, Heinold, Michael C., Hinton, Jonathan, Jones, David R., Menzies, Andrew, Stebbings, Lucy, Hess, Julian M., Rosenberg, Mara, Dunford, Andrew J., Gupta, Manaswi, Imielinski, Marcin, Meyerson, Matthew, Beroukhim, Rameen, Reimand, Juri, Dhingra, Priyanka, Favero, Francesco, Dentro, Stefan, Wintersinger, Jeff, Rudneva, Vasilisa, Park, Ji Wan, Hong, Eun Pyo, Heo, Seong Gu, Kahles, Andre, Soulette, Cameron M., Shiraishi, Yuichi, Liu, Fenglin, He, Yao, Demircioglu, Deniz, Davidson, Natalie R., Greger, Liliana, Li, Siliang, Liu, Dongbing, Stark, Stefan G., Zhang, Fan, Amin, Samirkumar B., Bailey, Peter, Chateigner, Aurelien, Frenkel-Morgenstern, Milana, Hou, Yong, Huska, Matthew R., Kilpinen, Helena, Lamaze, Fabien C., Li, Chang, Li, Xiaobo, Li, Xinyue, Liu, Xingmin, Marin, Maximillian G., Markowski, Julia, Nandi, Tannistha, Ojesina, Akinyemi, I, Pan-Hammarstrom, Qiang, Park, Peter J., Pedamallu, Chandra Sekhar, Su, Hong, Tan, Patrick, Teh, Bin Tean, Wang, Jian, Xiong, Heng, Ye, Chen, Yung, Christina, Zhang, Xiuqing, Zheng, Liangtao, Zhu, Shida, Awadalla, Philip, Creighton, Chad J., Wu, Kui, Yang, Huanming, Goke, Jonathan, Zhang, Zemin, Brooks, Angela N., Martincorena, Inigo, Rubio-Perez, Carlota, Juul, Malene, Schumacher, Steven, Shapira, Ofer, Tamborero, David, Mularoni, Loris, Hornshoj, Henrik, Deu-Pons, Jordi, Muinos, Ferran, Bertl, Johanna, Guo, Qianyun, Bazant, Wojciech, Barrera, Elisabet, Al-Sedairy, Sultan T., Aretz, Axel, Bell, Cindy, Betancourt, Miguel, Buchholz, Christiane, Calvo, Fabien, Chomienne, Christine, Dunn, Michael, Edmonds, Stuart, Green, Eric, Gupta, Shailja, Hutter, Carolyn M., Jegalian, Karine, Jones, Nic, Lu, Youyong, Nakagama, Hitoshi, Nettekoven, Gerd, Planko, Laura, Scott, David, Shibata, Tatsuhiro, Shimizu, Kiyo, Stratton, Michael R., Yugawa, Takashi, Tortora, Giampaolo, VijayRaghavan, K., Zenklusen, Jean C., Knoppers, Bartha M., Aminou, Brice, Bartolome, Javier, Boroevich, Keith A., Boyce, Rich, Buchanan, Alex, Byrne, Niall J., Chen, Zhaohong, Cho, Sunghoon, Choi, Wan, Clapham, Peter, Dow, Michelle T., Dursi, Lewis Jonathan, Eils, Juergen, Farcas, Claudiu, Fayzullaev, Nodirjon, Flicek, Paul, Heath, Allison P., Hofmann, Oliver, Hong, Jongwhi H., Hudson, Thomas J., Huebschmann, Daniel, Ivkovic, Sinisa, Jeon, Seung-Hyup, Jiao, Wei, Kabbe, Rolf, Kerssemakers, Jules N. A., Kim, Hyunghwan, Kim, Jihoon, Koscher, Michael, Koures, Antonios, Kovacevic, Milena, Lawerenz, Chris, Liu, Jia, Mijalkovic, Sanja, Mijalkovic-Lazic, Ana Mijalkovic, Miyano, Satoru, Nastic, Mia, Nicholson, Jonathan, Ocana, David, Ohi, Kazuhiro, Ohno-Machado, Lucila, Pihl, Todd D., Prinz, Manuel, Radovic, Petar, Short, Charles, Sofia, Heidi J., Spring, Jonathan, Struck, Adam J., Tijanic, Nebojsa, Vicente, David, Wang, Zhining, Williams, Ashley, Woo, Youngchoon, Wright, Adam J., Yang, Liming, Hamilton, Mark P., Johnson, Todd A., Kahraman, Abdullah, Kellis, Manolis, Polak, Paz, Sallari, Richard, Sinnott-Armstrong, Nasa, von Mering, Christian, Beltran, Sergi, Gerhard, Daniela S., Gut, Marta, Trotta, Jean-Remi, Whalley, Justin P., Niu, Beifang, Espiritu, Shadrielle M. G., Gao, Shengjie, Huang, Yi, Lalansingh, Christopher M., Teague, Jon W., Wendl, Michael C., Abascal, Federico, Bader, Gary D., Bandopadhayay, Pratiti, Barenboim, Jonathan, Brunak, Soren, Fita, Joana Carlevaro, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Choi, Jung Kyoon, Diamanti, Klev, Fink, J. Lynn, Frigola, Joan, Gambacorti-Passerini, Carlo, Garsed, Dale W., Haradhvala, Nicholas J., Harmanci, Arif O., Helmy, Mohamed, Herrmann, Carl, Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Isaev, Keren, Izarzugaza, Jose M. G., Johnson, Rory, Juul, Randi Istrup, Kim, Jaegil, Kim, Jong K., Komorowski, Jan, Lanzos, Andres, Larsson, Erik, Lee, Donghoon, Li, Shantao, Li, Xiaotong, Lin, Ziao, Liu, Eric Minwei, Lochovsky, Lucas, Lou, Shaoke, Madsen, Tobias, Marchal, Kathleen, Fundichely, Alexander Martinez, McGillivray, Patrick D., Meyerson, William, Paczkowska, Marta, Park, Keunchil, Park, Kiejung, Pons, Tirso, Pulido-Tamayo, Sergio, Reyes Salazar, Iker, Reyna, Matthew A., Rubin, Mark A., Salichos, Leonidas, Sander, Chris, Schumacher, Steven E., Shackleton, Mark, Shen, Ciyue, Shrestha, Raunak, Shuai, Shimin, Tsunoda, Tatsuhiko, Umer, Husen M., Uuskula-Reimand, Liis, Verbeke, Lieven P. C., Wadelius, Claes, Wadi, Lina, Warrell, Jonathan, Wu, Guanming, Yu, Jun, Zhang, Jing, Zhang, Xuanping, Zhang, Yan, Zhao, Zhongming, Zou, Lihua, Lawrence, Michael S., Raphael, Benjamin J., Bailey, Peter J., Craft, David, Goldman, Mary J., Aburatani, Hiroyuki, Binder, Hans, Dinh, Huy Q., Heath, Simon C., Hoffmann, Steve, Imbusch, Charles David, Kretzmer, Helene, Laird, Peter W., Martin-Subero, Jose, I, Nagae, Genta, Shen, Hui, Wang, Qi, Weichenhan, Dieter, Zhou, Wanding, Berman, Benjamin P., Brors, Benedikt, Plass, Christoph, Akdemir, Kadir C., Bowtell, David D. L., Burns, Kathleen H., Busanovich, John, Chan, Kin, Dueso-Barroso, Ana, Edwards, Paul A., Etemadmoghadam, Dariush, Haber, James E., Jones, David T. W., Ju, Young Seok, Kazanov, Marat D., Koh, Youngil, Kumar, Kiran, Lee, Eunjung Alice, Lee, Jake June-Koo, Lynch, Andy G., Macintyre, Geoff, Markowetz, Florian, Navarro, Fabio C. P., Pearson, John, V, Rippe, Karsten, Scully, Ralph, Villasante, Izar, Waddell, Nicola, Yang, Lixing, Yao, Xiaotong, Yoon, Sung-Soo, Zhang, Cheng-Zhong, Bergstrom, Erik N., Boot, Arnoud, Covington, Kyle, Fujimoto, Akihiro, Huang, Mi Ni, Islam, S. M. Ashiqul, McPherson, John R., Morganella, Sandro, Mustonen, Ville, Ng, Alvin Wei Tian, Prokopec, Stephenie D., Vazquez-Garcia, Ignacio, Wu, Yang, Yousif, Fouad, Yu, Willie, Rozen, Steven G., Rudneva, Vasilisa A., Shringarpure, Suyash S., Turner, Daniel J., Xia, Tian, Atwal, Gurnit, Chang, David K., Cooke, Susanna L., Faltas, Bishoy M., Haider, Syed, Kaiser, Vera B., Karlic, Rosa, Kato, Mamoru, Kubler, Kirsten, Margolin, Adam, Martin, Sancha, Nik-Zainal, Serena, P'ng, Christine, Semple, Colin A., Smith, Jaclyn, Sun, Ren X., Thai, Kevin, Wright, Derek W., Yuan, Ke, Biankin, Andrew, V, Garraway, Levi, Grimmond, Sean M., Adams, David J., Anur, Pavana, Cao, Shaolong, Christie, Elizabeth L., Cmero, Marek, Cun, Yupeng, Dawson, Kevin J., Dentro, Stefan C., Deshwar, Amit G., Donmez, Nilgun, Drews, Ruben M., Gerstung, Moritz, Ha, Gavin, Haase, Kerstin, Jerman, Lara, Ji, Yuan, Jolly, Clemency, Lee, Juhee, Lee-Six, Henry, Malikic, Salem, Mitchell, Thomas J., Morris, Quaid D., Oesper, Layla, Peifer, Martin, Peto, Myron, Rosebrock, Daniel, Rubanova, Yulia, Salcedo, Adriana, Sengupta, Subhajit, Shi, Ruian, Shin, Seung Jun, Spiro, Oliver, Vembu, Shankar, Wintersinger, Jeffrey A., Yang, Tsun-Po, Yu, Kaixian, Zhu, Hongtu, Spellman, Paul T., Weinstein, John N., Chen, Yiwen, Fujita, Masashi, Han, Leng, Hasegawa, Takanori, Komura, Mitsuhiro, Li, Jun, Mizuno, Shinichi, Shimizu, Eigo, Wang, Yumeng, Xu, Yanxun, Yamaguchi, Rui, Yang, Fan, Yang, Yang, Yoon, Christopher J., Yuan, Yuan, Liang, Han, Alawi, Malik, Borozan, Ivan, Brewer, Daniel S., Cooper, Colin S., Desai, Nikita, Grundhoff, Adam, Iskar, Murat, Su, Xiaoping, Zapatka, Marc, Lichter, Peter, Alsop, Kathryn, Bruxner, Timothy J. C., Christ, Angelika N., Cordner, Stephen M., Cowin, Prue A., Drapkin, Ronny, Fereday, Sian, George, Joshy, Hamilton, Anne, Holmes, Oliver, Hung, Jillian A., Kassahn, Karin S., Kazakoff, Stephen H., Kennedy, Catherine J., Leonard, Conrad R., Mileshkin, Linda, Miller, David K., Arnau, Gisela Mir, Mitchell, Chris, Newell, Felicity, Nones, Katia, Patch, Ann-Marie, Quinn, Michael C., Taylor, Darrin F., Thorne, Heather, Traficante, Nadia, Vedururu, Ravikiran, Waddell, Nick M., Waring, Paul M., Wood, Scott, Xu, Qinying, DeFazio, Anna, Anderson, Matthew J., Antonello, Davide, Barbour, Andrew P., Bassi, Claudio, Bersani, Samantha, Cataldo, Ivana, Chantrill, Lorraine A., Chiew, Yoke-Eng, Chou, Angela, Cingarlini, Sara, Cloonan, Nicole, Corbo, Vincenzo, Davi, Maria Vittoria, Duthie, Fraser R., Gill, Anthony J., Graham, Janet S., Harliwong, Ivon, Jamieson, Nigel B., Johns, Amber L., Kench, James G., Landoni, Luca, Lawlor, Rita T., Mafficini, Andrea, Merrett, Neil D., Miotto, Marco, Musgrove, Elizabeth A., Nagrial, Adnan M., Oien, Karin A., Pajic, Marina, Pinese, Mark, Robertson, Alan J., Rooman, Ilse, Rusev, Borislav C., Samra, Jaswinder S., Scardoni, Maria, Scarlett, Christopher J., Scarpa, Aldo, Sereni, Elisabetta, Sikora, Katarzyna O., Simbolo, Michele, Taschuk, Morgan L., Toon, Christopher W., Vicentini, Caterina, Wu, Jianmin, Zeps, Nikolajs, Behren, Andreas, Burke, Hazel, Cebon, Jonathan, Dagg, Rebecca A., De Paoli-Iseppi, Ricardo, Dutton-Regester, Ken, Field, Matthew A., Fitzgerald, Anna, Hersey, Peter, Jakrot, Valerie, Johansson, Peter A., Kakavand, Hojabr, Kefford, Richard F., Lau, Loretta M. S., Long, Georgina, V, Pickett, Hilda A., Pritchard, Antonia L., Pupo, Gulietta M., Saw, Robyn P. M., Schramm, Sarah-Jane, Shang, Catherine A., Shang, Ping, Spillane, Andrew J., Stretch, Jonathan R., Tembe, Varsha, Thompson, John F., Vilain, Ricardo E., Wilmott, James S., Yang, Jean Y., Hayward, Nicholas K., Mann, Graham J., Scolyer, Richard A., Bartlett, John, Bavi, Prashant, Chadwick, Dianne E., Chan-Seng-Yue, Michelle, Cleary, Sean, Connor, Ashton A., Czajka, Karolina, Denroche, Robert E., Dhani, Neesha C., Eagles, Jenna, Gallinger, Steven, Grant, Robert C., Hedley, David, Hollingsworth, Michael A., Jang, Gun Ho, Johns, Jeremy, Kalimuthu, Sangeetha, Liang, Sheng-Ben, Lungu, Ilinca, Luo, Xuemei, Mbabaali, Faridah, McPherson, Treasa A., Miller, Jessica K., Moore, Malcolm J., Notta, Faiyaz, Pasternack, Danielle, Petersen, Gloria M., Roehrl, Michael H. A., Sam, Michelle, Selander, Iris, Serra, Stefano, Shahabi, Sagedeh, Thayer, Sarah P., Timms, Lee E., Wilson, Gavin W., Wilson, Julie M., Wouters, Bradly G., McPherson, John D., Beck, Timothy A., Bhandari, Vinayak, Collins, Colin C., Fleshner, Neil E., Fox, Natalie S., Fraser, Michael, Heisler, Lawrence E., Lalonde, Emilie, Livingstone, Julie, Meng, Alice, Sabelnykova, Veronica Y., Shiah, Yu-Jia, Van Der Kwast, Theodorus, Bristow, Robert G., Ding, Shuai, Fan, Daiming, Li, Lin, Nie, Yongzhan, Xiao, Xiao, Xing, Rui, Yang, Shanlin, Yu, Yingyan, Zhou, Yong, Banks, Rosamonde E., Bourque, Guillaume, Brennan, Paul, Letourneau, Louis, Riazalhosseini, Yasser, Scelo, Ghislaine, Vasudev, Naveen, Viksna, Juris, Lathrop, Mark, Tost, Jorg, Ahn, Sung-Min, Aparicio, Samuel, Arnould, Laurent, Aure, M. R., Bhosle, Shriram G., Birney, Ewan, Borg, Ake, Boyault, Sandrine, Brinkman, Arie B., Brock, Jane E., Broeks, Annegien, Borresen-Dale, Anne-Lise, Caldas, Carlos, Chin, Suet-Feung, Davies, Helen, Desmedt, Christine, Dirix, Luc, Dronov, Serge, Ehinger, Anna, Eyfjord, Jorunn E., Fatima, Aquila, Foekens, John A., Futreal, P. Andrew, Garred, Oystein, Giri, Dilip D., Glodzik, Dominik, Grabau, Dorthe, Hilmarsdottir, Holmfridur, Hooijer, Gerrit K., Jacquemier, Jocelyne, Jang, Se Jin, Jonasson, Jon G., Jonkers, Jos, Kim, Hyung-Yong, King, Tari A., Knappskog, Stian, Kong, Gu, Krishnamurthy, Savitri, Lakhani, Sunil R., Langerod, Anita, Larsimont, Denis, Lee, Hee Jin, Lee, Jeong-Yeon, Lee, Ming Ta Michael, Lingjaerde, Ole Christian, MacGrogan, Gaetan, Martens, John W. M., O'Meara, Sarah, Pauporte, Iris, Pinder, Sarah, Pivot, Xavier, Provenzano, Elena, Purdie, Colin A., Ramakrishna, Manasa, Ramakrishnan, Kamna, Reis-Filho, Jorge, Richardson, Andrea L., Ringner, Markus, Rodriguez, Javier Bartolome, Rodriguez-Gonzalez, F. German, Romieu, Gilles, Salgado, Roberto, Sauer, Torill, Shepherd, Rebecca, Sieuwerts, Anieta M., Simpson, Peter T., Smid, Marcel, Sotiriou, Christos, Span, Paul N., Stefansson, Olafur Andri, Stenhouse, Alasdair, Stunnenberg, Henk G., Sweep, Fred, Tan, Benita Kiat Tee, Thomas, Gilles, Thompson, Alastair M., Tommasi, Stefania, Treilleux, Isabelle, Tutt, Andrew, Ueno, Naoto T., Van Laere, Steven, Van den Eynden, Gert G., Vermeulen, Peter, Viari, Alain, Vincent-Salomon, Anne, Wong, Bernice H., Yates, Lucy, Zou, Xueqing, van Deurzen, Carolien H. M., van de Vijver, Marc J., van't Veer, Laura, Ammerpohl, Ole, Aukema, Sietse, Bergmann, Anke K., Bernhart, Stephan H., Borkhardt, Arndt, Borst, Christoph, Burkhardt, Birgit, Claviez, Alexander, Goebler, Maria Elisabeth, Haake, Andrea, Haas, Siegfried, Hansmann, Martin, Hoell, Jessica, I, Hummel, Michael, Karsch, Dennis, Klapper, Wolfram, Kneba, Michael, Kreuz, Markus, Kube, Dieter, Kueppers, Ralf, Lenze, Dido, Loeffler, Markus, Lopez, Cristina, Mantovani-Loeffler, Luisa, Moeller, Peter, Ott, German, Radlwimmer, Bernhard, Richter, Julia, Rohde, Marius, Rosenstiel, Philip C., Rosenwald, Andreas, Schilhabel, Markus B., Schreiber, Stefan, Stadler, Peter F., Staib, Peter, Stilgenbauer, Stephan, Sungalee, Stephanie, Szczepanowski, Monika, Toprak, Umut H., Truemper, Lorenz H. P., Wagener, Rabea, Zenz, Thorsten, Hovestadt, Volker, von Kalle, Christof, Kool, Marcel, Korshunov, Andrey, Landgraf, Pablo, Lehrach, Hans, Northcott, Paul A., Pfister, Stefan M., Reifenberger, Guido, Warnatz, Hans-Joerg, Wolf, Stephan, Yaspo, Marie-Laure, Assenov, Yassen, Gerhauser, Clarissa, Minner, Sarah, Schlomm, Thorsten, Simon, Ronald, Sauter, Guido, Sueltmann, Holger, Biswas, Nidhan K., Maitra, Arindam, Majumder, Partha P., Sarin, Rajiv, Barbi, Stefano, Bonizzato, Giada, Cantu, Cinzia, Dei Tos, Angelo P., Fassan, Matteo, Grimaldi, Sonia, Luchini, Claudio, Malleo, Giuseppe, Marchegiani, Giovanni, Milella, Michele, Paiella, Salvatore, Pea, Antonio, Pederzoli, Paolo, Ruzzenente, Andrea, Salvia, Roberto, Sperandio, Nicola, Arai, Yasuhito, Hama, Natsuko, Hiraoka, Nobuyoshi, Hosoda, Fumie, Nakamura, Hiromi, Ojima, Hidenori, Okusaka, Takuji, Totoki, Yasushi, Urushidate, Tomoko, Fukayama, Masashi, Ishikawa, Shumpei, Katai, Hitoshi, Katoh, Hiroto, Komura, Daisuke, Rokutan, Hirofumi, Saito-Adachi, Mihoko, Suzuki, Akihiro, Taniguchi, Hirokazu, Tatsuno, Kenji, Ushiku, Tetsuo, Yachida, Shinichi, Yamamoto, Shogo, Aikata, Hiroshi, Arihiro, Koji, Ariizumi, Shun-ichi, Chayama, Kazuaki, Furuta, Mayuko, Gotoh, Kunihito, Hayami, Shinya, Hirano, Satoshi, Kawakami, Yoshiiku, Maejima, Kazuhiro, Nakamura, Toru, Nakano, Kaoru, Ohdan, Hideki, Sasaki-Oku, Aya, Tanaka, Hiroko, Ueno, Masaki, Yamamoto, Masakazu, Yamaue, Hiroki, Choo, Su Pin, Cutcutache, Ioana, Khuntikeo, Narong, Ong, Choon Kiat, Pairojkul, Chawalit, Popescu, Irinel, Ahn, Keun Soo, Aymerich, Marta, Lopez-Guillermo, Armando, Lopez-Otin, Carlos, Puente, Xose S., Campo, Elias, Amary, Fernanda, Baumhoer, Daniel, Behjati, Sam, Bjerkehagen, Bodil, Futreal, P. A., Myklebost, Ola, Pillay, Nischalan, Tarpey, Patrick, Tirabosco, Roberto, Zaikova, Olga, Flanagan, Adrienne M., Boultwood, Jacqueline, Bowen, David T., Cazzola, Mario, Green, Anthony R., Hellstrom-Lindberg, Eva, Malcovati, Luca, Nangalia, Jyoti, Papaemmanuil, Elli, Vyas, Paresh, Ang, Yeng, Barr, Hugh, Beardsmore, Duncan, Eldridge, Matthew, Gossage, James, Grehan, Nicola, Hanna, George B., Hayes, Stephen J., Hupp, Ted R., Khoo, David, Lagergren, Jesper, Lovat, Laurence B., MacRae, Shona, O'Donovan, Maria, O'Neill, J. Robert, Parsons, Simon L., Preston, Shaun R., Puig, Sonia, Roques, Tom, Sanders, Grant, Sothi, Sharmila, Tavare, Simon, Tucker, Olga, Turkington, Richard, Underwood, Timothy J., Welch, Ian, Fitzgerald, Rebecca C., Berney, Daniel M., De Bono, Johann S., Cahill, Declan, Camacho, Niedzica, Dennis, Nening M., Dudderidge, Tim, Edwards, Sandra E., Fisher, Cyril, Foster, Christopher S., Ghori, Mohammed, Gill, Pelvender, Gnanapragasam, Vincent J., Gundem, Gunes, Hamdy, Freddie C., Hawkins, Steve, Hazell, Steven, Howat, William, Isaacs, William B., Karaszi, Katalin, Kay, Jonathan D., Khoo, Vincent, Kote-Jarai, Zsofia, Kremeyer, Barbara, Kumar, Pardeep, Lambert, Adam, Leongamornlert, Daniel A., Livni, Naomi, Lu, Yong-Jie, Luxton, Hayley J., Marsden, Luke, Massie, Charlie E., Matthews, Lucy, Mayer, Erik, McDermott, Ultan, Merson, Sue, Neal, David E., Ng, Anthony, Nicol, David, Ogden, Christopher, Rowe, Edward W., Shah, Nimish C., Thomas, Sarah, Thompson, Alan, Verrill, Clare, Visakorpi, Tapio, Warren, Anne Y., Whitaker, Hayley C., Zhang, Hongwei, van As, Nicholas, Eeles, Rosalind A., Abeshouse, Adam, Agrawal, Nishant, Akbani, Rehan, Al Ahmadie, Hikmat, Albert, Monique, Aldape, Kenneth, Ally, Adrian, Appelbaum, Elizabeth L., Armenia, Joshua, Asa, Sylvia, Auman, J. Todd, Balasundaram, Miruna, Balu, Saianand, Barnholtz-Sloan, Jill, Bathe, Oliver F., Baylin, Stephen B., Benz, Christopher, Berchuck, Andrew, Berrios, Mario, Bigner, Darell, Birrer, Michael, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S., Bosenberg, Marcus, Bowlby, Reanne, Boyd, Jeffrey, Broaddus, Russell R., Brock, Malcolm, Brooks, Denise, Bullman, Susan, Caesar-Johnson, Samantha J., Carey, Thomas E., Carlsen, Rebecca, Cerfolio, Robert, Chandan, Vishal S., Chen, Hsiao-Wei, Cherniack, Andrew D., Chien, Jeremy, Cho, Juok, Chuah, Eric, Cibulskis, Carrie, Cope, Leslie, Cordes, Matthew G., Curley, Erin, Czerniak, Bogdan, Danilova, Ludmila, Davis, Ian J., Defreitas, Timothy, Demchok, John A., Dhalla, Noreen, Dhir, Rajiv, Doddapaneni, HarshaVardhan, El-Naggar, Adel, Felau, Ina, Ferguson, Martin L., Finocchiaro, Gaetano, Fong, Kwun M., Frazer, Scott, Friedman, William, Fronick, Catrina C., Fulton, Lucinda A., Gabriel, Stacey B., Gao, Jianjiong, Gehlenborg, Nils, Gershenwald, Jeffrey E., Ghossein, Ronald, Giama, Nasra H., Gibbs, Richard A., Gomez, Carmen, Govindan, Ramaswamy, Hayes, D. Neil, Hegde, Apurva M., Heiman, David, I, Heins, Zachary, Hepperla, Austin J., Holbrook, Andrea, Holt, Robert A., Hoyle, Alan P., Hruban, Ralph H., Hu, Jianhong, Huang, Mei, Huntsman, David, Huse, Jason, Donahue, Christine A. Iacobuzio, Ittmann, Michael, Jayaseelan, Joy C., Jefferys, Stuart R., Jones, Corbin D., Jones, Steven J. M., Juhl, Hartmut, Kang, Koo Jeong, Karlan, Beth, Kasaian, Katayoon, Kebebew, Electron, Kim, Hark Kyun, Korchina, Viktoriya, Kundra, Ritika, Lai, Phillip H., Lander, Eric, Le, Xuan, Lee, Darlene, Levine, Douglas A., Lewis, Lora, Ley, Tim, Li, Haiyan Irene, Lin, Pei, Linehan, W. M., Liu, Fei Fei, Lu, Yiling, Lype, Lisa, Ma, Yussanne, Maglinte, Dennis T., Mardis, Elaine R., Marks, Jeffrey, Marra, Marco A., Matthew, Thomas J., Mayo, Michael, McCune, Karen, Meier, Samuel R., Meng, Shaowu, Mieczkowski, Piotr A., Mikkelsen, Tom, Miller, Christopher A., Mills, Gordon B., Moore, Richard A., Morrison, Carl, Mose, Lisle E., Moser, Catherine D., Mungall, Andrew J., Mungall, Karen, Mutch, David, Muzny, Donna M., Myers, Jerome, Newton, Yulia, Noble, Michael S., O'Donnell, Peter, O'Neill, Brian Patrick, Ochoa, Angelica, Park, Joong-Won, Parker, Joel S., Pass, Harvey, Pastore, Alessandro, Pennell, Nathan A., Perou, Charles M., Petrelli, Nicholas, Potapova, Olga, Rader, Janet S., Ramalingam, Suresh, Rathmell, W. Kimryn, Reuter, Victor, Reynolds, Sheila M., Ringel, Matthew, Roach, Jeffrey, Roberts, Lewis R., Robertson, A. Gordon, Sadeghi, Sara, Saller, Charles, Sanchez-Vega, Francisco, Schadendorf, Dirk, Schein, Jacqueline E., Schmidt, Heather K., Schultz, Nikolaus, Seethala, Raja, Senbabaoglu, Yasin, Shelton, Troy, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Shriver, Craig, Signoretti, Sabina, Simons, Janae, V, Singer, Samuel, Sipahimalani, Payal, Skelly, Tara J., McCune, Karen Smith, Socci, Nicholas D., Soloway, Matthew G., Sood, Anil K., Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Thiessen, Nina, Thompson, R. Houston, Thorne, Leigh B., Tsao, Ming, Umbricht, Christopher, Van Den Berg, David J., Van Meir, Erwin G., Veluvolu, Umadevi, Voet, Douglas, Wang, Linghua, Weinberger, Paul, Weisenberger, Daniel J., Wigle, Dennis, Wilkerson, Matthew D., Wilson, Richard K., Winterhoff, Boris, Wiznerowicz, Maciej, Wong, Tina, Wong, Winghing, Xi, Liu, Yau, Christina, Zhang, Hailei, Zhang, Hongxin, and Zhang, Jiashan

Abstract

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).

Published
2020

64. Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2

Author

Wang, Daxi, primary, Wang, Yanqun, additional, Sun, Wanying, additional, Zhang, Lu, additional, Ji, Jingkai, additional, Zhang, Zhaoyong, additional, Cheng, Xinyi, additional, Li, Yimin, additional, Xiao, Fei, additional, Zhu, Airu, additional, Zhong, Bei, additional, Ruan, Shicong, additional, Li, Jiandong, additional, Ren, Peidi, additional, Ou, Zhihua, additional, Xiao, Minfeng, additional, Li, Min, additional, Deng, Ziqing, additional, Zhong, Huanzi, additional, Li, Fuqiang, additional, Wang, Wen-jing, additional, Zhang, Yongwei, additional, Chen, Weijun, additional, Zhu, Shida, additional, Xu, Xun, additional, Jin, Xin, additional, Zhao, Jingxian, additional, Zhong, Nanshan, additional, Zhang, Wenwei, additional, Zhao, Jincun, additional, Li, Junhua, additional, and Xu, Yonghao, additional

Published
2021
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65. Comprehensive evaluation of BRCA1/2 variant interpretation ability among laboratories in China

Author

Shao, Kang, primary, Wang, Ruixia, additional, Qu, Shoufang, additional, Zhang, Wenxin, additional, Yu, Ting, additional, Cao, Boyang, additional, Dai, Pingping, additional, Zhu, Anna, additional, Zhang, Jianguang, additional, Wang, Juan, additional, Wang, Lusheng, additional, Zhu, Shida, additional, Wu, Kui, additional, Yang, Xuexi, additional, Chang, Xiaoyan, additional, Chen, Fang, additional, and Huang, Jie, additional

Published
2021
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66. Genetic signatures for lineage/sublineage classification of HPV16, 18, 52 and 58 variants

Author

Ou, Zhihua, primary, Chen, Zigui, additional, Zhao, Yanping, additional, Lu, Haorong, additional, Liu, Wei, additional, Li, Wangsheng, additional, Ren, Peidi, additional, Geng, Chunyu, additional, Xiao, Minfeng, additional, Hu, Guohai, additional, Wu, Di, additional, Wang, Xiaman, additional, Liu, Na, additional, Zhu, Shida, additional, Lu, Ling, additional, and Li, Junhua, additional

Published
2021
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67. Characterization of genomic clones by targeted deep sequencing of ctDNA to monitor liver cancer

Author

Sun, Yan, primary, Kong, Xiaoyu, additional, Yu, Jing, additional, Zheng, Xiaolin, additional, Lin, Mufei, additional, Cheng, Zhengyu, additional, Wang, Hui, additional, An, Na, additional, Xie, Ying, additional, Zeng, Shuang, additional, Xue, Siming, additional, Xia, Min, additional, Wei, Xia, additional, Song, Lijie, additional, Liu, Fengxia, additional, Fan, Chunna, additional, Fang, Zhonghai, additional, Gao, Liangjun, additional, Yang, Yun, additional, Zhu, Shida, additional, and Shi, Taiping, additional

Published
2021
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68. Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas

Author

Ye, Xiaofei, primary, Ren, Weicheng, additional, Liu, Dongbing, additional, Li, Xiaobo, additional, Li, Wei, additional, Wang, Xianhuo, additional, Meng, Fei-Long, additional, Yeap, Leng-Siew, additional, Hou, Yong, additional, Zhu, Shida, additional, Casellas, Rafael, additional, Zhang, Huilai, additional, Wu, Kui, additional, and Pan-Hammarström, Qiang, additional

Published
2020
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69. IDDF2020-ABS-0141 The gut microbiome and serum metabolome orchestrate healthy aging and longevity with novel implications for renal function

Author

Li, Zhiming, primary, Sun, Liang, additional, Hu, Caiyou, additional, Ding, Jiahong, additional, Zhou, Qi, additional, Sun, Yuzhe, additional, Li, Rui, additional, Zhen, Hefu, additional, Sun, Shuqin, additional, Zhang, Jianmin, additional, Liu, Chuanfa, additional, Fang, Mingyan, additional, Chen, Zhihuan, additional, Lv, Yuan, additional, Cao, Qizhi, additional, Sun, Yanan, additional, Huang, Zezhi, additional, Yang, Ruiyue, additional, Dong, Jun, additional, Gong, Ranhui, additional, Li, Junchun, additional, Ruan, Jie, additional, Lu, Haorong, additional, Pang, Guofang, additional, He, Benjin, additional, Li, Ninghu, additional, Li, Tao, additional, Xue, Wenbin, additional, Li, Yan, additional, Shen, Juan, additional, Yang, Fan, additional, Zhao, Cheng, additional, Liang, Qinghua, additional, Zhang, Mingrong, additional, Chen, Chen, additional, Gong, Huan, additional, Yuan, Huiping, additional, Hou, Yong, additional, Wang, Jian, additional, Zhang, Ying, additional, Yang, Huanming, additional, Zhu, Shida, additional, Cai, Jianping, additional, Xiao, Liang, additional, Guo, Haiyun, additional, Zhao, Peng, additional, Li, Jian, additional, Pedersen, Susanne Brix, additional, Xu, Xun, additional, Jia, Huijue, additional, Kristiansen, Karsten, additional, and Yang, Ze, additional

Published
2020
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72. Clinical and molecular diagnostic study of 320 Chinese children with epilepsy by Genome Sequencing

Author

Zou, Dongfang, primary, Wang, Lin, additional, Liao, Jianxiang, additional, Xiao, Hongdou, additional, Duan, Jing, additional, Zhang, Tongda, additional, Yin, Zhenzhen, additional, Zhou, Jing, additional, Yan, Haisheng, additional, Huang, Yushan, additional, Li, Jianbiao, additional, Zhan, Nianji, additional, Yang, Ying, additional, Ye, Jingyu, additional, Chen, Fang, additional, Zhu, Shida, additional, Wen, Feiqiu, additional, and Guo, Jian, additional

Published
2020
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73. Characterization of Microbial Co-infections in the Respiratory Tract of hospitalized COVID-19 patients

Author

Zhong, Huanzi, primary, Wang, Yanqun, additional, Shi, Zhun, additional, Zhang, Lu, additional, Ren, Huahui, additional, He, Weiqun, additional, Zhang, Zhaoyong, additional, Zhu, Airu, additional, Zhao, Jingxian, additional, Xiao, Fei, additional, Yang, Fangming, additional, Liang, Tianzhu, additional, Ye, Feng, additional, Zhong, Bei, additional, Ruan, Shicong, additional, Gan, Mian, additional, Zhu, Jiahui, additional, Li, Fang, additional, Li, Fuqiang, additional, Wang, Daxi, additional, Li, Jiandong, additional, Ren, Peidi, additional, Zhu, Shida, additional, Yang, Huanming, additional, Wang, Jian, additional, Kristiansen, Karsten, additional, Tun, Hein Min, additional, Chen, Weijun, additional, Zhong, Nanshan, additional, Xu, Xun, additional, Li, Yi-min, additional, Li, Junhua, additional, and Zhao, Jincun, additional

Published
2020
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74. Comparative analysis of clonal evolution among patients with right-sided colon cancer, left-sided colon cancer and rectal cancer

Author

Banerjee, Santasree, primary, Zhang, Xianxiang, additional, Kuang, Shan, additional, Wang, Jigang, additional, Li, Lei, additional, Fan, Guangyi, additional, Luo, Yonglun, additional, Sun, Shuai, additional, Han, Peng, additional, Wu, Qingyao, additional, Yang, Shujian, additional, Ji, Xiaobin, additional, Li, Yong, additional, Deng, Li, additional, Tian, Xiaofen, additional, Wang, Zhiwei, additional, Zhang, Yue, additional, Wu, Kui, additional, Zhu, Shida, additional, Bolund, Lars, additional, Yang, Huanming, additional, Xu, Xun, additional, Liu, Junnian, additional, Lu, Yun, additional, and Liu, Xin, additional

Published
2020
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75. Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome

Author

Liu, Xiaomin, primary, Tong, Xin, additional, Zou, Yuanqiang, additional, Lin, Xiaoqian, additional, Zhao, Hui, additional, Tian, Liu, additional, Jie, Zhuye, additional, Wang, Qi, additional, Zhang, Zhe, additional, Lu, Haorong, additional, Xiao, Liang, additional, Qiu, Xuemei, additional, Zi, Jin, additional, Wang, Rong, additional, Xu, Xun, additional, Yang, Huanming, additional, Wang, Jian, additional, Zong, Yang, additional, Liu, Weibin, additional, Hou, Yong, additional, Zhu, Shida, additional, Jia, Huijue, additional, and Zhang, Tao, additional

Published
2020
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76. Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples

Author

Xiao, Minfeng, primary, Liu, Xiaoqing, additional, Ji, Jingkai, additional, Li, Min, additional, Li, Jiandong, additional, Yang, Lin, additional, Sun, Wanying, additional, Ren, Peidi, additional, Yang, Guifang, additional, Zhao, Jincun, additional, Liang, Tianzhu, additional, Ren, Huahui, additional, Chen, Tian, additional, Zhong, Huanzi, additional, Song, Wenchen, additional, Wang, Yanqun, additional, Deng, Ziqing, additional, Zhao, Yanping, additional, Ou, Zhihua, additional, Wang, Daxi, additional, Cai, Jielun, additional, Cheng, Xinyi, additional, Feng, Taiqing, additional, Wu, Honglong, additional, Gong, Yanping, additional, Yang, Huanming, additional, Wang, Jian, additional, Xu, Xun, additional, Zhu, Shida, additional, Chen, Fang, additional, Zhang, Yanyan, additional, Chen, Weijun, additional, Li, Yimin, additional, and Li, Junhua, additional

Published
2020
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77. Population Bottlenecks and Intra-host Evolution during Human-to-Human Transmission of SARS-CoV-2

Author

Wang, Daxi, primary, Wang, Yanqun, additional, Sun, Wanying, additional, Zhang, Lu, additional, Ji, Jingkai, additional, Zhang, Zhaoyong, additional, Cheng, Xinyi, additional, Li, Yimin, additional, Xiao, Fei, additional, Zhu, Airu, additional, Zhong, Bei, additional, Ruan, Shicong, additional, Li, Jiandong, additional, Ren, Peidi, additional, Ou, Zhihua, additional, Xiao, Minfeng, additional, Li, Min, additional, Deng, Ziqing, additional, Zhong, Huanzi, additional, Li, Fuqiang, additional, Wang, Wen-jing, additional, Zhang, Yongwei, additional, Chen, Weijun, additional, Zhu, Shida, additional, Xu, Xun, additional, Jin, Xin, additional, Zhao, Jingxian, additional, Zhong, Nanshan, additional, Zhang, Wenwei, additional, Zhao, Jincun, additional, Li, Junhua, additional, and Xu, Yonghao, additional

Published
2020
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79. Single cell chromatin accessibility of the developmental cephalochordate

Author

Chen, Dongsheng, primary, Huang, Zhen, additional, Ding, Xiangning, additional, Xu, Zaoxu, additional, Zhong, Jixing, additional, Liang, Langchao, additional, Xu, Luohao, additional, Cai, Chaochao, additional, Wang, Haoyu, additional, Qiu, Jiaying, additional, Zhu, Jiacheng, additional, Wang, Xiaoling, additional, Xiang, Rong, additional, Wu, Weiying, additional, Ding, Peiwen, additional, Wang, Feiyue, additional, Feng, Qikai, additional, Zhou, Si, additional, Yuan, Yuting, additional, Wu, Wendi, additional, Yan, Yanan, additional, Zhou, Yitao, additional, Chen, Duo, additional, Li, Guang, additional, Zhu, Shida, additional, Chen, Fang, additional, Zhang, Qiujin, additional, Wu, Jihong, additional, and Xu, Xun, additional

Published
2020
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80. Effect of large-scale testing platform in prevention and control of the COVID-19 pandemic: an empirical study with a novel numerical model

Author

Xie, Qing, primary, Wang, Jing, additional, You, Jianling, additional, Zhu, Shida, additional, Zhou, Rui, additional, Tian, Zhijian, additional, Wu, Hao, additional, Lin, Yang, additional, Chen, Wei, additional, Xiao, Lan, additional, Jin, Xin, additional, Li, Jianjuan, additional, Dong, Jie, additional, Wu, Honglong, additional, Zhang, Wei, additional, Li, Jing, additional, Xu, Xun, additional, Yin, Ye, additional, Mu, Feng, additional, Chen, Weijun, additional, and Jian, Wang, additional

Published
2020
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81. Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples

Author

Xiao, Minfeng, primary, Liu, Xiaoqing, additional, Ji, Jingkai, additional, Li, Min, additional, Li, Jiandong, additional, Yang, Lin, additional, Sun, Wanying, additional, Ren, Peidi, additional, Yang, Guifang, additional, Zhao, Jincun, additional, Liang, Tianzhu, additional, Ren, Huahui, additional, Chen, Tian, additional, Zhong, Huanzi, additional, Song, Wenchen, additional, Wang, Yanqun, additional, Deng, Ziqing, additional, Zhao, Yanping, additional, Ou, Zhihua, additional, Wang, Daxi, additional, Cai, Jielun, additional, Cheng, Xinyi, additional, Feng, Taiqing, additional, Wu, Honglong, additional, Gong, Yanping, additional, Yang, Huanming, additional, Wang, Jian, additional, Xu, Xun, additional, Zhu, Shida, additional, Chen, Fang, additional, Zhang, Yanyan, additional, Chen, Weijun, additional, Li, Yimin, additional, and Li, Junhua, additional

Published
2020
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82. Genome sequencing combining prenatal ultrasound in the evaluation of fetal CNS structural anomalies

Author

Yang, Ying, primary, Zhao, Sheng, additional, Sun, Guoqiang, additional, Chen, Fang, additional, Zhang, Tongda, additional, Song, Jieping, additional, Yang, Wenzhong, additional, Wang, Lin, additional, Zhan, Nianji, additional, Yang, Xiaohong, additional, Zhu, Xia, additional, Rao, Bin, additional, Yin, Zhenzhen, additional, Zhou, Jing, additional, Yan, Haisheng, additional, Huang, Yushan, additional, Ye, Jingyu, additional, Huang, Hui, additional, Cheng, Chen, additional, Zhu, Shida, additional, Guo, Jian, additional, Xu, Xun, additional, and Chen, Xinlin, additional

Published
2020
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83. Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson’s disease mouse brain

Author

Zhong, Jixing, primary, Tang, Gen, additional, Zhu, Jiacheng, additional, Qiu, Xin, additional, Wu, Weiying, additional, Li, Ge, additional, Lin, Xiumei, additional, Liang, Langchao, additional, Chai, Chaochao, additional, Zeng, Yuying, additional, Wang, Feiyue, additional, Luo, Lihua, additional, Li, Jiankang, additional, Chen, Fang, additional, Huang, Zhen, additional, Xu, Xun, additional, Tang, Shengping, additional, Zhu, Shida, additional, and Chen, Dongsheng, additional

Published
2020
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84. Intratumor Heterogeneity and Evolution of Colorectal Cancer

Author

Banerjee, Santasree, primary, Zhang, Xianxiang, additional, Kuang, Shan, additional, Wang, Jigang, additional, Li, Lei, additional, Fan, Guangyi, additional, Luo, Yonglun, additional, Sun, Shuai, additional, Han, Peng, additional, Wu, Qingyao, additional, Yang, Shujian, additional, Ji, Xiaobin, additional, Li, Yong, additional, Deng, Li, additional, Tian, Xiaofen, additional, Wang, Zhiwei, additional, Zhang, Yue, additional, Wu, Kui, additional, Zhu, Shida, additional, Bolund, Lars, additional, Yang, Huanming, additional, Xu, Xun, additional, Liu, Junnian, additional, Lu, Yun, additional, and Liu, Xin, additional

Published
2020
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85. Single cell atlas of trisomy 21 cerebral cortex

Author

Zhang, Jingxuan, primary, Wang, Shiyou, additional, Xu, Zaoxu, additional, Ding, Xiangning, additional, Li, Chen, additional, Zhang, Yonghong, additional, Chen, Yin, additional, Zhong, Jixing, additional, Liang, Langchao, additional, Chai, Chaochao, additional, Wang, Xiaoling, additional, Xiang, Rong, additional, Zhu, Jiacheng, additional, Lin, Xiumei, additional, Ding, Peiwen, additional, Zhang, Qiang, additional, Wang, Mingyue, additional, Feng, Qikai, additional, Zhang, Zhijun, additional, Guo, Guangling, additional, Xue, Shen, additional, Jin, Lin, additional, He, Zhikai, additional, Yan, Li, additional, Xiao, Bing, additional, Zhang, Changjun, additional, Xu, Yan, additional, Li, Wei, additional, Zhang, Yichi, additional, Wu, Weiying, additional, Jiang, Sanjie, additional, Xia, Jun, additional, Gao, Ya, additional, Wang, Lei, additional, Dong, Shichen, additional, Liu, Si, additional, Zhu, Shida, additional, Chen, Fang, additional, Chen, Dongsheng, additional, and Xu, Xun, additional

Published
2020
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86. Single cell atlas of domestic pig brain illuminates the conservation and divergence of cell types at spatial and species levels

Author

Chen, Dongsheng, primary, Zhu, Jiacheng, additional, Zhong, Jixing, additional, Chen, Fang, additional, Lin, Xiumei, additional, Dai, Jinxia, additional, Chen, Yin, additional, Wang, Shiyou, additional, Ding, Xiangning, additional, Wang, Haoyu, additional, Qiu, Jiaying, additional, Wang, Feiyue, additional, Wu, Weiying, additional, Liu, Ping, additional, Tang, Gen, additional, Qiu, Xin, additional, Ruan, Yetian, additional, Li, Jiankang, additional, Zhu, Shida, additional, Xu, Xun, additional, Li, Fang, additional, Liu, Zhongmin, additional, and Cao, Gang, additional

Published
2019
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87. PALM-Seq: integrated sequencing of cell-free long RNA and small RNA

Author

Yang, Xi, primary, Wang, Taifu, additional, Zhu, Sujun, additional, Zeng, Juan, additional, Xing, Yanru, additional, Zhou, Qing, additional, Liu, Zhongzhen, additional, Chen, Haixiao, additional, Sun, Jinghua, additional, Li, Liqiang, additional, Xu, Jinjin, additional, Geng, Chunyu, additional, Xu, Xun, additional, Wang, Jian, additional, Yang, Huanming, additional, Zhu, Shida, additional, Chen, Fang, additional, and Wang, Wen-Jing, additional

Published
2019
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89. A Reference System for BRCA Mutation Detection Based on Next-Generation Sequencing in the Chinese Population

Author

Qu, Shoufang, primary, Chen, Qiong, additional, Yi, Yuting, additional, Shao, Kang, additional, Zhang, Wenxin, additional, Wang, Yin, additional, Bai, Jian, additional, Li, Xuchao, additional, Liu, Zhiyuan, additional, Wang, Xiaowen, additional, Jing, Ruilin, additional, Guan, Yanfang, additional, Yi, Xin, additional, Yan, Miaoli, additional, Cao, Boyang, additional, Chen, Feng, additional, Zhu, Shida, additional, Yang, Xuexi, additional, Wu, Yingsong, additional, and Huang, Jie, additional

Published
2019
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91. Age-dependent sexual dimorphism in the adult human gut microbiota

Author

Zhang, Xiuying, primary, Zhong, Huanzi, additional, Li, Yufeng, additional, Shi, Zhun, additional, Zhang, Zhe, additional, Zhou, Xianghai, additional, Ren, Huahui, additional, Tang, Shanmei, additional, Han, Xueyao, additional, Lin, Yuxiang, additional, Wang, Dan, additional, Yang, Fangming, additional, Fang, Chao, additional, Fu, Zuodi, additional, Wang, Lianying, additional, Zhu, Shida, additional, Hou, Yong, additional, Xu, Xun, additional, Yang, Huanming, additional, Wang, Jian, additional, Kristiansen, Karsten, additional, Li, Junhua, additional, and Ji, Linong, additional

Published
2019
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92. Gene Panel Sequencing in a Chinese High-risk Breast Cancer Cohort

Author

Zhang, Xianyu, primary, Wang, Xiaohong, additional, Song, Bingbing, additional, Shao, Kang, additional, Li, Guibo, additional, Jian, Wenjing, additional, Lin, Cong, additional, Wang, Min, additional, Ye, Xiaofei, additional, Xie, Jingjing, additional, Xia, Bingshu, additional, Xu, Shouping, additional, Cao, Boyang, additional, Xiao, Liyun, additional, Zhang, Zhao, additional, Liu, Meng, additional, Fang, Enhao, additional, Jin, Haoxuan, additional, Wei, Xiaofeng, additional, Dean, Michael, additional, Wang, Jian, additional, Yang, Huanming, additional, Wang, Xianming, additional, Zhu, Shida, additional, Hou, Yong, additional, and Pang, Da, additional

Published
2019
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93. High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

Author

Zhang, Yiqun, Chen, Fengju, Fonseca, Nuno A., He, Yao, Fujita, Masashi, Nakagawa, Hidewaki, Zhang, Zemin, Brazma, Alvis, Amin, Samirkumar B., Awadalla, Philip, Bailey, Peter J., Brooks, Angela N., Calabrese, Claudia, Chateigner, Aurélien, Cortés-Ciriano, Isidro, Craft, Brian, Craft, David, Creighton, Chad J., Davidson, Natalie R., Demircioğlu, Deniz, Erkek, Serap, Frenkel-Morgenstern, Milana, Goldman, Mary J., Greger, Liliana, Göke, Jonathan, Hoadley, Katherine A., Hou, Yong, Huska, Matthew R., Kahles, Andre, Khurana, Ekta, Kilpinen, Helena, Korbel, Jan O., Lamaze, Fabien C., Lehmann, Kjong Van, Li, Chang, Li, Siliang, Li, Xiaobo, Li, Xinyue, Liu, Dongbing, Liu, Fenglin, Liu, Xingmin, Nielsen, Morten Muhlig, Pedersen, Jakob Skou, Wu, Kui, Zhu, Shida, Sidiropoulos, Nikos, Weischenfeldt, Joachim, University of St Andrews. School of Medicine, University of St Andrews. Statistics, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Cellular Medicine Division, Fonseca, Nuno A [0000-0003-4832-578X], Fujita, Masashi [0000-0002-1457-6233], Brazma, Alvis [0000-0001-5988-7409], Creighton, Chad J [0000-0002-6090-703X], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Cancer Research, Chemistry(all), Medizin, General Physics and Astronomy, Regulatory Sequences, Nucleic Acid, Genome, 0302 clinical medicine, Ecology,Evolution & Ethology, Neoplasms, Databases, Genetic, Cancer genomics, 2.1 Biological and endogenous factors, Genes, Tumor Suppressor, Aetiology, lcsh:Science, Càncer, Cancer, Regulation of gene expression, Genetics, Human Biology & Physiology, Multidisciplinary, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], 3rd-DAS, 3. Good health, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Gene Expression Regulation, Neoplastic, Enhancer Elements, Genetic, Regulatory sequence, 030220 oncology & carcinogenesis, DNA methylation, PCAWG Structural Variation Working Group, Genetics & Genomics, Tumor Suppressor, Biotechnology, PCAWG Transcriptome Working Group, Enhancer Elements, Science, Repressor, QH426 Genetics, Biology, Physics and Astronomy(all), General Biochemistry, Genetics and Molecular Biology, Article, RC0254, 03 medical and health sciences, Databases, Rare Diseases, Genetic, SDG 3 - Good Health and Well-being, Humans, Enhancer, Gene, QH426, Computational & Systems Biology, Neoplastic, Nucleic Acid, Whole Genome Sequencing, RC0254 Neoplasms. Tumors. Oncology (including Cancer), Biochemistry, Genetics and Molecular Biology(all), Human Genome, Breakpoint, PCAWG Consortium, General Chemistry, Oncogenes, Tumour Biology, DNA Methylation, Genòmica, 030104 developmental biology, Gene Expression Regulation, Genes, Genomic Structural Variation, lcsh:Q, Gene expression, Digestive Diseases, Regulatory Sequences, Genètica
Abstract

The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common set of 1220 cancer cases, we report hundreds of genes for which the presence within 100 kb of an SV breakpoint associates with altered expression. For the majority of these genes, expression increases rather than decreases with corresponding breakpoint events. Up-regulated cancer-associated genes impacted by this phenomenon include TERT, MDM2, CDK4, ERBB2, CD274, PDCD1LG2, and IGF2. TERT-associated breakpoints involve ~3% of cases, most frequently in liver biliary, melanoma, sarcoma, stomach, and kidney cancers. SVs associated with up-regulation of PD1 and PDL1 genes involve ~1% of non-amplified cases. For many genes, SVs are significantly associated with increased numbers or greater proximity of enhancer regulatory elements near the gene. DNA methylation near the promoter is often increased with nearby SV breakpoint, which may involve inactivation of repressor elements., In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Published
2017

94. Comprehensive evaluation of BRCA1/2 variant interpretation ability among laboratories in China

Author

Shao, Kang, Wang, Ruixia, Qu, Shoufang, Zhang, Wenxin, Yu, Ting, Cao, Boyang, Dai, Pingping, Zhu, Anna, Zhang, Jianguang, Wang, Juan, Wang, Lusheng, Zhu, Shida, Wu, Kui, Yang, Xuexi, Chang, Xiaoyan, Chen, Fang, and Huang, Jie

Abstract

High-quality interpretation of BRCA1/2variants plays a critical role in the clinical practice of precision medicine. However, a comprehensive system to evaluate the quality and accuracy of variant interpretation has yet to be established. This study investigates the performance of an interpretation system in evaluating the capacities of BRCA1/2interpretation among distinct laboratories in China. The evaluation system is based on a reference database that contains 750 different variants in BRCA1/2. Evaluation was performed among 41 laboratories in China. We classified their performance into five levels. Only level A was considered qualified. This level allows for a 0.3% error rate for clinical decision-related misinterpretation; 26 of 41 laboratories (63%) met the qualified standard, while 7 laboratories were at levels D and E, which indicated egregious mistakes and systemic problems in variant interpretation. Due to strict quality demands, the interpretation of several variants was amended, which largely influenced the quality rate. The number of qualified laboratories would decrease from 26 to 17 if those incorrect recommended interpretations were not corrected. This evaluation system provides a potential approach for standardisation of variant interpretation and lowers the discordance of variant interpretation between different laboratories. A well-designed interpretation ability evaluation is essential to evaluate the interpretation level of laboratories before they provide service in real-world clinical settings.

Published
2022
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95. Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

Author

Wang, Qiuju, primary, Xiang, Jiale, additional, Sun, Jun, additional, Yang, Yun, additional, Guan, Jing, additional, Wang, Dayong, additional, Song, Cui, additional, Guo, Ling, additional, Wang, Hongyang, additional, Chen, Yaqiu, additional, Leng, Junhong, additional, Wang, Xiaman, additional, Zhang, Junqing, additional, Han, Bing, additional, Zou, Jing, additional, Yan, Chenbin, additional, Zhao, Lidong, additional, Luo, Hongyu, additional, Han, Yuan, additional, Yuan, Wen, additional, Zhang, Hongyun, additional, Wang, Wei, additional, Wang, Jian, additional, Yang, Huanming, additional, Xu, Xun, additional, Yin, Ye, additional, Morton, Cynthia C., additional, Zhao, Lijian, additional, Zhu, Shida, additional, Shen, Jun, additional, and Peng, Zhiyu, additional

Published
2018
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96. Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning

Author

Huang, Jian, primary, Qian, Zhaoyang, additional, Gong, Yuhua, additional, Wang, Yanzhou, additional, Guan, Yanfang, additional, Han, Yingxin, additional, Yi, Xin, additional, Huang, Wanqiu, additional, Ji, Liyan, additional, Xu, Jiajia, additional, Su, Mengyuan, additional, Yuan, Qing, additional, Cui, Shujian, additional, Zhang, Jinling, additional, Bao, Chaohui, additional, Liu, Weilong, additional, Chen, Xi, additional, Zhang, Ming, additional, Gao, Xiaohuan, additional, Wu, Renhua, additional, Zhang, Yinxin, additional, Xu, Huicheng, additional, Zhu, Shida, additional, Zhu, Hongmei, additional, Yang, Ling, additional, Xu, Xun, additional, Zhou, Pingyu, additional, and Liang, Zhiqing, additional

Published
2018
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97. Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation

Author

Shang, Zhouchun, Chen, Dongsheng, Wang, Quanlei, Wang, Shengpeng, Deng, Qiuting, Wu, Liang, Liu, Chuanyu, Ding, Xiangning, Wang, Shiyou, Zhong, Jixing, Zhang, Doudou, Cai, Xiaodong, Zhu, Shida, Yang, Huanming, Liu, Longqi, Fink, J Lynn, Chen, Fang, Liu, Xiaoqing, Gao, Zhengliang, Xu, Xun, Shang, Zhouchun, Chen, Dongsheng, Wang, Quanlei, Wang, Shengpeng, Deng, Qiuting, Wu, Liang, Liu, Chuanyu, Ding, Xiangning, Wang, Shiyou, Zhong, Jixing, Zhang, Doudou, Cai, Xiaodong, Zhu, Shida, Yang, Huanming, Liu, Longqi, Fink, J Lynn, Chen, Fang, Liu, Xiaoqing, Gao, Zhengliang, and Xu, Xun

Abstract

Background: Investigating cell fate decision and subpopulation specification in the context of the neural lineage is fundamental to understanding neurogenesis and neurodegenerative diseases. The differentiation process of neural-tube-like rosettes in vitro is representative of neural tube structures, which are composed of radially organized, columnar epithelial cells and give rise to functional neural cells. However, the underlying regulatory network of cell fate commitment during early neural differentiation remains elusive. Results: In this study, we investigated the genome-wide transcriptome profile of single cells from six consecutive reprogramming and neural differentiation time points and identified cellular subpopulations present at each differentiation stage. Based on the inferred reconstructed trajectory and the characteristics of subpopulations contributing the most toward commitment to the central nervous system lineage at each stage during differentiation, we identified putative novel transcription factors in regulating neural differentiation. In addition, we dissected the dynamics of chromatin accessibility at the neural differentiation stages and revealed active cis-regulatory elements for transcription factors known to have a key role in neural differentiation as well as for those that we suggest are also involved. Further, communication network analysis demonstrated that cellular interactions most frequently occurred in the embryoid body stage and that each cell subpopulation possessed a distinctive spectrum of ligands and receptors associated with neural differentiation that could reflect the identity of each subpopulation. Conclusions: Our study provides a comprehensive and integrative study of the transcriptomics and epigenetics of human early neural differentiation, which paves the way for a deeper understanding of the regulatory mechanisms driving the differentiation of the neural lineage.

Published
2018

99. Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease Progression

Author

Ren, Shancheng, Wei, Gong-Hong, Liu, Dongbing, Wang, Liguo, Hou, Yong, Zhu, Shida, Peng, Lihua, Zhang, Qin, Cheng, Yanbing, Su, Hong, Zhou, Xiuqing, Zhang, Jibin, Li, Fuqiang, Zheng, Hancheng, Zhao, Zhikun, Yin, Changjun, He, Zengquan, Gao, Xin, Zhau, Haiyen E., Chu, Chia-Yi, Wu, Jason Boyang, Collins, Colin, Volik, Stanislav V, Bell, Robert, Huang, Jiaoti, Wu, Kui, Xu, Danfeng, Ye, Dingwei, Yu, Yongwei, Zhu, Lianhui, Qiao, Meng, Lee, Hang-Mao, Yang, Yuehong, Zhu, Yasheng, Shi, Xiaolei, Chen, Rui, Wang, Yang, Xu, Weidong, Cheng, Yanqiong, Xu, Chuanliang, Gao, Xu, Zhou, Tie, Yang, Bo, Hou, Jianguo, Liu, Li, Zhang, Zhensheng, Zhu, Yao, Qin, Chao, Shao, Pengfei, Pang, Jun, Chung, Leland W. K., Xu, Jianfeng, Wu, Chin-Lee, Zhong, Weide, Xu, Xun, Li, Yingrui, Zhang, Xiuqing, Wang, Jian, Yang, Huanming, Wang, Jun, Huang, Haojie, Sun, Yinghao, Ren, Shancheng, Wei, Gong-Hong, Liu, Dongbing, Wang, Liguo, Hou, Yong, Zhu, Shida, Peng, Lihua, Zhang, Qin, Cheng, Yanbing, Su, Hong, Zhou, Xiuqing, Zhang, Jibin, Li, Fuqiang, Zheng, Hancheng, Zhao, Zhikun, Yin, Changjun, He, Zengquan, Gao, Xin, Zhau, Haiyen E., Chu, Chia-Yi, Wu, Jason Boyang, Collins, Colin, Volik, Stanislav V, Bell, Robert, Huang, Jiaoti, Wu, Kui, Xu, Danfeng, Ye, Dingwei, Yu, Yongwei, Zhu, Lianhui, Qiao, Meng, Lee, Hang-Mao, Yang, Yuehong, Zhu, Yasheng, Shi, Xiaolei, Chen, Rui, Wang, Yang, Xu, Weidong, Cheng, Yanqiong, Xu, Chuanliang, Gao, Xu, Zhou, Tie, Yang, Bo, Hou, Jianguo, Liu, Li, Zhang, Zhensheng, Zhu, Yao, Qin, Chao, Shao, Pengfei, Pang, Jun, Chung, Leland W. K., Xu, Jianfeng, Wu, Chin-Lee, Zhong, Weide, Xu, Xun, Li, Yingrui, Zhang, Xiuqing, Wang, Jian, Yang, Huanming, Wang, Jun, Huang, Haojie, and Sun, Yinghao

Abstract

BACKGROUND: Global disparities in prostate cancer (PCa) incidence highlight the urgent need to identify genomic abnormalities in prostate tumors in different ethnic populations including Asian men.OBJECTIVE: To systematically explore the genomic complexity and define disease-driven genetic alterations in PCa.DESIGN, SETTING, AND PARTICIPANTS: The study sequenced whole-genome and transcriptome of tumor-benign paired tissues from 65 treatment-naive Chinese PCa patients. Subsequent targeted deep sequencing of 293 PCa-relevant genes was performed in another cohort of 145 prostate tumors.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The genomic alteration landscape in PCa was analyzed using an integrated computational pipeline. Relationships with PCa progression and survival were analyzed using nonparametric test, log-rank, and multivariable Cox regression analyses.RESULTS AND LIMITATIONS: We demonstrated an association of high frequency of CHD1 deletion with a low rate of TMPRSS2-ERG fusion and relatively high percentage of mutations in androgen receptor upstream activator genes in Chinese patients. We identified five putative clustered deleted tumor suppressor genes and provided experimental and clinical evidence that PCDH9, deleted/loss in approximately 23% of tumors, functions as a novel tumor suppressor gene with prognostic potential in PCa. Furthermore, axon guidance pathway genes were frequently deregulated, including gain/amplification of PLXNA1 gene in approximately 17% of tumors. Functional and clinical data analyses showed that increased expression of PLXNA1 promoted prostate tumor growth and independently predicted prostate tumor biochemical recurrence, metastasis, and poor survival in multi-institutional cohorts of patients with PCa. A limitation of this study is that other genetic alterations were not experimentally investigated.CONCLUSIONS: There are shared and salient genetic characteristics of PCa in Chinese and Cau

Published
2018

100. Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation

Author

Shang, Zhouchun, primary, Chen, Dongsheng, additional, Wang, Quanlei, additional, Wang, Shengpeng, additional, Deng, Qiuting, additional, Wu, Liang, additional, Liu, Chuanyu, additional, Ding, Xiangning, additional, Wang, Shiyou, additional, Zhong, Jixing, additional, Zhang, Doudou, additional, Cai, Xiaodong, additional, Zhu, Shida, additional, Yang, Huanming, additional, Liu, Longqi, additional, Fink, J Lynn, additional, Chen, Fang, additional, Liu, Xiaoqing, additional, Gao, Zhengliang, additional, and Xu, Xun, additional

Published
2018
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