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Comprehensive Summary: With the emergence of Y‐series small molecule acceptors, polymerizing the small molecule acceptors with aromatic linker units has attracted significant research attention, which has greatly advanced the photovoltaic performance of all‐polymer solar cells. Despite the rapid increase in efficiency, the unique characteristics (e. g., mechanical stretchability and flexibility) of all‐polymer systems were still not thoroughly explored. In this work, we demonstrate an effective approach to simultaneously improve device performance, stability, and mechanical robustness of all‐polymer solar cells by properly suppressing the aggregation and crystallization behaviors of polymerized Y‐series acceptors. Strikingly, when introducing 50 wt% PYF‐IT (a fluorinated version of PY‐IT) into the well‐known PM6:PY‐IT system, the all‐polymer devices delivered an impressive photovoltaic efficiency of 16.6%, significantly higher than that of the control binary cell (15.0%). Compared with the two binary systems, the optimal ternary blend exhibits more efficient charge separation and balanced charge transport accompanying with less recombination. Moreover, a high‐performance 1.0 cm2 large‐area device of 15% efficiency was demonstrated for the optimized ternary all‐polymer blend, which offered a desirable PCE of 14.5% on flexible substrates and improved mechanical flexibility after bending 1000 cycles. Notably, these are among the best results for 1.0 cm2 all‐polymer OPVs thus far. This work also heralds a bright future of all‐polymer systems for flexible wearable energy‐harvesting applications. [ABSTRACT FROM AUTHOR]

Comprehensive Summary: With the emergence of Y‐series small molecule acceptors, polymerizing the small molecule acceptors with aromatic linker units has attracted significant research attention, which has greatly advanced the photovoltaic performance of all‐polymer solar cells. Despite the rapid increase in efficiency, the unique characteristics (e. g., mechanical stretchability and flexibility) of all‐polymer systems were still not thoroughly explored. In this work, we demonstrate an effective approach to simultaneously improve device performance, stability, and mechanical robustness of all‐polymer solar cells by properly suppressing the aggregation and crystallization behaviors of polymerized Y‐series acceptors. Strikingly, when introducing 50 wt% PYF‐IT (a fluorinated version of PY‐IT) into the well‐known PM6:PY‐IT system, the all‐polymer devices delivered an impressive photovoltaic efficiency of 16.6%, significantly higher than that of the control binary cell (15.0%). Compared with the two binary systems, the optimal ternary blend exhibits more efficient charge separation and balanced charge transport accompanying with less recombination. Moreover, a high‐performance 1.0 cm2 large‐area device of 15% efficiency was demonstrated for the optimized ternary all‐polymer blend, which offered a desirable PCE of 14.5% on flexible substrates and improved mechanical flexibility after bending 1000 cycles. Notably, these are among the best results for 1.0 cm2 all‐polymer OPVs thus far. This work also heralds a bright future of all‐polymer systems for flexible wearable energy‐harvesting applications. [ABSTRACT FROM AUTHOR]

The Correction Notice in the Journal of Hematology & Oncology addresses an error in the original article regarding a duplicate figure. The corrected figure displays Ct values of plasma methylated OTOP2 and KCNA3 for participants, along with receiver operating characteristics curves for different stages of esophageal cancer. The study focuses on a non-invasive diagnosis of esophageal cancer using a simplified circulating cell-free DNA methylation assay targeting specific genes. The correction provides valuable insights for researchers and healthcare professionals interested in advancements in cancer diagnosis. [Extracted from the article]

Background: Esophageal cancer (EC) is a highly lethal disease lacking early detection approaches. We previously identified that OTOP2 and KCNA3 were specifically hypermethylated in circulating cell-free DNA from patients with EC. We then developed a blood-based methylation assay targeting OTOP2 and KCNA3 (named "IEsohunter") for esophageal cancer noninvasive detection. This double-blinded, multicenter, prospective study aimed to comprehensively evaluate its clinical diagnostic performance. Methods: Participants with EC, high-grade intraepithelial neoplasia (HGIN), other malignancies, benign gastrointestinal lesions, or no abnormalities were prospectively enrolled from 5 tertiary referral centers across China. Peripheral blood samples were collected, followed by plasma cell-free DNA methylation analysis using the IEsohunter test based on multiplex quantitative polymerase chain reaction adopting an algorithm-free interpretation strategy. The primary outcome was the diagnostic accuracy of IEsohunter test for EC. Results: We prospectively enrolled 1116 participants, including 334 patients with EC, 71 with HGIN, and 711 controls. The areas under the receiver operating characteristic curves of the IEsohunter test for detecting EC and HGIN were 0.903 (95% CI 0.880–0.927) and 0.727 (95% CI 0.653–0.801), respectively. IEsohunter test showed sensitivities of 78.5% (95% CI 69.1–85.6), 87.3% (95% CI 79.4–92.4), 92.5% (95% CI 85.9–96.2), and 96.9% (95% CI 84.3–99.8) for stage I-IV EC, respectively, with an overall sensitivity of 87.4% (95% CI 83.4–90.6) and specificity of 93.3% (95% CI 91.2–94.9) for EC detection. The IEsohunter test status turned negative (100.0%, 47/47) after surgical resection of EC. Conclusions: The IEsohunter test showed high diagnostic accuracy for EC detection, indicating that it could potentially serve as a tool for noninvasive early detection and surveillance of EC. [ABSTRACT FROM AUTHOR]

Flexible strain sensors capable of acquiring tiny mechanical signals and attaching to various irregular surfaces are becoming prevalent in physiological measurement, soft robotics, and human‐machine interaction. However, the advancement of flexible strain sensors is substantially impeded by the intrinsic compromise between sensitivity and the range of detectable signals. Inspired by the multilayer structure of nacre in nature, a carbon nanotubes (CNTs)/graphene (GR)/graphene (GR)/thermoplastic polyurethane (TPU) mat (CGGTM) is prepared by electrospinning and high‐pressure spraying technology. By designing a multilayer structure with mutually non‐interfering conductive networks, the resulting CGGTM possesses a low detection limit (0.05% strain), high sensitivity (gauge factor, GF > 152537), large detection range (up to 364% strain), fast response/recovery time (80 ms/100 ms), and excellent cyclic durability (up to 1000 cycles). Furthermore, the CGGTM also exhibits satisfactory triboelectric performances when assembled into a triboelectric nanogenerator (TENG, 3 × 3 cm2), including high triboelectric output (open‐circuit voltage Voc = 135.4 V, short‐circuit current Isc = 1.25 µA) and power density (88 mW m−2), enabling reliable power supply, self‐powered sensing, and pulse monitoring capability. Finally, CGGTM is successfully applied to the collection of biological signals and multi‐gesture motion recognition assisted by machine learning algorithms, which holds promise for intelligent interaction with gestures in the future. [ABSTRACT FROM AUTHOR]

Concurrently achieving high efficiency, mechanical robustness and thermal stability is critical for the commercialization of all‐polymer solar cells (APSCs). However, APSCs usually demonstrate complicated morphology, primarily attributed to the polymer chain entanglement which has a detrimental effect on their fill factors (FF) and morphology stability. To address these concerns, an end‐group extended polymer acceptor, PY‐NFT, was synthesized and studied. The morphology analysis showed a tightly ordered molecular packing mode and a favorable phase separation was formed. The PM6 : PY‐NFT‐based device achieved an exceptional PCE of 19.12 % (certified as 18.45 %), outperforming the control PM6 : PY‐FT devices (17.14 %). This significant improvement highlights the record‐high PCE for binary APSCs. The thermal aging study revealed that the PM6 : PY‐NFT blend exhibited excellent morphological stability, thereby achieving superior device stability, retaining 90 % of initial efficiency after enduring thermal stress (65 °C) for 1500 hours. More importantly, the PM6 : PY‐NFT blend film exhibited outstanding mechanical ductility with a crack onset strain of 24.1 %. Overall, rational chemical structure innovation, especially the conjugation extension strategy to trigger appropriate phase separation and stable morphology, is the key to achieving high efficiency, improved thermal stability and robust mechanical stability of APSCs. [ABSTRACT FROM AUTHOR]

The article lists the contributions of various researchers, including Tanveer Ahmad, Naoki Aratani, and Umair Azhar covering diverse topics such as organic synthesis, catalysis, and material science.

Herein, the catalytic effects of aromatic amines with different structures on the room temperature curing of bisphenol E cyanate (BECy) have been studied using differential scanning calorimetry (DSC) and Fourier transform infrared (FT-IR) spectroscopy. Our results revealed that the mixed amine comprised of aniline and N,N-dimethyl-p-phenylenediamine (AN/NNDPA) bearing primary amino groups in its structure was a highly effective catalyst for the room temperature curing of cyanate esters. When the cyanate ester and mixed amine were combined at a molar ratio of 100:5 and cured at room temperature for 5 days, the curing degree of BECy resin reached 79.7%. The room temperature curing mechanism of the BECy-AN/NNDPA system was investigated using pyrolysis gas chromatography-mass spectrometry (PY GC-MS). Our results showed that the formation reactions of the intermediate structure and cyclotrimerization reactions occurred during the room-temperature curing process. The activation energies of BECy and different aromatic amine systems at different heating rates were determined using non-isothermal DSC. The results further demonstrated the catalytic effect of AN/NNDPA on the cyanate ester curing reaction. BECy-AN/NNDPA cured at room temperature has suitable heat resistance and a 5% weight loss temperature (Td5) of 361°C. [ABSTRACT FROM AUTHOR]

Paclitaxel (PTX) resistance is a key cause of chemotherapy failure in patients with triple negative breast cancer (TNBC). The aim of this study is to investigate the effect and mechanism of long non‐coding RNA (lncRNA) on the PTX resistance of TNBC cells through autophagy. MDA‐MB‐231 cells are used to induce the PTX‐resistant TNBC cell line MDA‐MB‐231.PR (MDR) by increasing dose intermittently. Quantitative real‐time polymerase chain reaction (qRT‐PCR) was used to validate the mRNA levels of phosphoinositide‐3‐kinase class 3 (PIK3C3), miR‐361‐5p and lncRNA PRKCQ‐AS1 in the cells, and Western blot analysis was used to detect the protein expressions of PIK3C3, autophagy‐related, drug‐resistant and apoptosis‐related genes. MDC staining detected the formation of autophagic vacuoles. The interactions between miR‐361‐5p and PIK3C3 and between lncRNA PRKCQ‐AS1 and miR‐361‐5p were verified by dual‐luciferase assay. Cell viability, apoptosis, migration and invasion were assessed by performing MTT, flow cytometry assay, and transwell assay. The mRNA level of miR‐361‐5p and the autophagy and drug resistance levels of TNBC PTX‐resistant cells were significantly up‐regulated. miR‐361‐5p could target autophagy‐related gene PIK3C3, and overexpression of miR‐361‐5p could down‐regulate PIK3C3 protein expression and autophagy level and PTX resistance of MDR cells. LncRNA PRKCQ‐AS1 was selected through bioanalysis, and miR‐361‐5p could target lncRNA PRKCQ‐AS1. In addition, lncRNA PRKCQ‐AS1 level was up‐regulated in TNBC PTX‐resistant cells, and knockdown of lncRNA PRKCQ‐AS1 could weaken autophagy and drug resistance level and could promote cell apoptosis. Overexpression of lncRNA PRKCQ‐AS1 reversed the pro‐apoptotic effect and down‐regulation of autophagy and resistance levels was induced by miR‐361‐5p. In vivo experiments were performed to verify the role of lncRNA PRKCQ‐AS1. We demonstrate that down‐regulation of lncRNA PRKCQ‐AS1 weakened PTX resistance and promoted cell apoptosis by miR‐361‐5p/PIK3C3 mediated autophagy. [ABSTRACT FROM AUTHOR]

High-density polyethylene (HDPE) is one of the most commonly used materials for manufacturing pipelines. In this paper, the deformation behavior of HDPE materials under uniaxial tensile stress was investigated by employing uniaxial tensile tests and macroscale/mesoscale morphology analysis. The experimental results indicated that the stress–strain relationship of HDPE is nonlinear, and the ductile fracture characteristics of necking and local failure appear in the sample after the engineering strain reaches 35%. Therefore, for the first time, a hyperelastoplastic constitutive model that describes the elasticity by the Marlow model and combined the isotropic plasticity-ductility damage correction is established, and a corresponding numerical approach is proposed. The simulation scheme was implemented in finite-element software, and the mechanical responses of HDPE under uniaxial tensile and bending loads were predicted. Obtained calculations were relatively consistent with experimental observations. Hence, the proposed model and approach have a good simulation effect on the mechanical properties of HDPE and can be employed for the process prediction of such materials. This study is beneficial to the in-depth understanding of the hyperelastoplasticity and failure mechanism of HDPE and provides ideas for the deformation and failure study of other polymer materials. [ABSTRACT FROM AUTHOR]

Weida Fu,* Shurong Zheng,* Jieyu Zhou, Kangkang Lu, Yiqiao Lu, Guilong Guo Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guilong Guo, Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China, Tel/Fax +86-13867709361, Email guoguilong@sina.comAbstract: Male breast carcinoma metastatic to the choroid is very rare and often related to poor prognosis. Herein, we report the findings in a Chinese male breast cancer patient who developed choroidal metastasis, and give opinions on systemic treatments. A 45-year-old Chinese male represented with difficulty breathing and visual impairment in the left eye 6 years after his breast cancer surgery and postoperative adjuvant treatment. PET/CT revealed multi-organs metastasis of the patient. The IHC indicated the lung lesion to be originated from the breast (ER+/PR+/HER2-). Eye examination provided evidence for breast cancer choroidal metastasis. Two cycles of TX (docetaxel + capecitabine) followed by two courses of GP (gemcitabine + cis-platinum) were applied as salvage chemotherapy. Metastases in his lung and bone remained stable. As for choroidal metastasis, a regimen of CDK4/6 inhibitor (Palbociclib) plus fulvestrant was recommended to the patient, which led to a good response. Notably, CDK4/6 inhibitor combined with endocrine therapy may be considered as an effective treatment for hormonal receptor-positive breast cancer patients with choroidal metastasis. We recommend that eye examination should not be neglected in breast cancer patients.Keywords: choroidal metastasis, male breast cancer, systemic therapy, CDK4/6 inhibitor, case report

Phoebe minutiflora H. W. Li, is a member of the Lauraceae family, while its generic relationship has been long-term controversial. The complete chloroplast (cp) genome of P. minutiflora was first reported in this paper. The cp genome was 152,654 bp in length with four typical quadripartite structures, which was consisted of a large single-copy (LSC) region of 93,697 bp, a small single-copy (SSC) region of 18,809 bp, and two inverted repeats (IRs) of 20,074 bp. In addition, there were a total of 112 unique genes, including 79 protein-coding genes, 29 tRNA genes, and four rRNA genes. The phylogenetic analysis indicated that P. minutiflora should be placed into Machilus. [ABSTRACT FROM AUTHOR]

Long non-coding RNAs (lncRNAs), a recently characterized class of non-coding RNAs, have been shown to have important regulatory roles and are de-regulated in a variety of tumors. However, the contributions of lncRNAs to gastric carcinoma and their functional mechanisms remain largely unknown. In this study, we found that lncRNA gastric carcinoma high expressed transcript 1 (lncRNA-GHET1) was up-regulated in gastric carcinoma. The over-expression of this lncRNA correlates with tumor size, tumor invasion and poor survival. Gain-of-function and loss-of-function analyses demonstrated that GHET1 over-expression promotes the proliferation of gastric carcinoma cells in vitro and in vivo. Knockdown of GHET1 inhibits the proliferation of gastric carcinoma cells. RNA pull-down and immunoprecipitation assays confirmed that GHET1 physically associates with insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) and enhances the physical interaction between c-Myc mRNA and IGF2BP1, consequently increasing the stability of c-Myc mRNA and expression. The expression of GHET1 and c-Myc is strongly correlated in gastric carcinoma tissues. Depletion of c-Myc abolishes the effects of GHET1 on proliferation of gastric carcinoma cells. Taken together, these findings indicate that GHET1 plays a pivotal role in gastric carcinoma cell proliferation via increasing c-Myc mRNA stability and expression, which suggests potential use of GHET1 for the prognosis and treatment of gastric carcinoma. [ABSTRACT FROM AUTHOR]