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249 results on '"Zhou, Huafeng"'

53. Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules

Author

Yan Zemin, Zhou Huafeng, Yue Yang, Liu Guanlan, Li Yan, Zhang Jing, and Duan Mingxing

Subjects
Coenzyme Q10, Cryo-TEM, DSC, Topical delivery, Lipid nanocapsules, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Abstract The purpose of this study was to investigate the influence of the inner lipid ratio on the physicochemical properties and skin targeting of surfactant-free lecithin-based coenzyme Q10-loaded lipid nanocapsules (CoQ10-LNCs). The smaller particle size of CoQ10-LNCs was achieved by high pressure and a lower ratio of CoQ10/GTCC (Caprylic/capric triglyceride); however, the zeta potential of CoQ10-LNCs was above /− 60 mV/ with no distinct difference among them at different ratios of CoQ10/GTCC. Both the crystallisation point and the index decreased with the decreasing ratio of CoQ10/GTCC and smaller particle size; interestingly, the supercooled state of CoQ10-LNCs was observed at particle size below about 200 nm, as verified by differential scanning calorimetry (DSC) in one heating–cooling cycle. The lecithin monolayer sphere structure of CoQ10-LNCs was investigated by cryogenic transmission electron microscopy (Cryo-TEM). The skin penetration results revealed that the distribution of Nile red-loaded CoQ10-LNCs depended on the ratio of inner CoQ10/GTCC; moreover, epidermal targeting and superficial dermal targeting were achieved by the CoQ10-LNCs application. The highest fluorescence response was observed at a ratio of inner CoQ10/GTCC of 1:1. These observations suggest that lecithin-based LNCs could be used as a promising topical delivery vehicle for lipophilic compounds.

Published
2010
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54. Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System

Author

Yan Zemin, Zhou Huafeng, Yue Yang, Liu Guanlan, Li Yan, Zhang Jing, Gong Qiu, and Duan Mingxing

Subjects
Lecithin, Nanoemulsion, Fluorescence, Topical delivery system, Skin hydration, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Abstract Purpose of this study was to establish a lecithin nanoemulsion (LNE) without any synthetic surfactant as a topical delivery vehicle and to evaluate its topical delivery potential by the following factors: particle size, morphology, viscosity, stability, skin hydration and skin penetration. Experimental results demonstrated that an increasing concentration of soybean lecithin and glycerol resulted in a smaller size LNE droplet and increasing viscosity, respectively. The droplet size of optimized LNE, with the glycerol concentration above 75% (w/w), changed from 92 (F10) to 58 nm (F14). Additionally, LNE, incorporated into o/w cream, improved the skin hydration capacity of the cream significantly with about 2.5-fold increase when the concentration of LNE reached 10%. LNE was also demonstrated to improve the penetrability of Nile red (NR) dye into the dermis layer, when an o/w cream, incorporated with NR-loaded LNE, applied on the abdominal skin of rat in vivo. Specifically, the arbitrary unit (ABU) of fluorescence in the dermis layer that had received the cream with a NR-loaded LNE was about 9.9-fold higher than the cream with a NR-loaded general emulsion (GE). These observations suggest that LNE could be used as a promising topical delivery vehicle for lipophilic compounds.

Published
2009
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60. A Power Market Nodal Price Forecasting Based on Historical Electricity Price and Unified Dispatch Load

Author

Zhou Huafeng, Peng Chaoyi, Yawei Chi, Huijie Gu, and Xun Yi

Subjects
Electric power system, business.industry, Computer science, Econometrics, Sampling (statistics), Spot market, Electricity, Bidding, business, Regression, Data modeling, Random forest
Abstract

With the progress of the reform in the electricity power system, all 8 electricity spot market pilot provinces have initiated trial runs of electricity spot market settlement and the staged progress has been achieved. As the major clearing pricing mechanism in current domestic power spot market, the forecasting of nodalprice plays an instructive role for mastering the law of nodal price fluctuations and generating bidding and offering strategies. This paper proceeds the day-ahead nodal price forecast for sampling 40 nodes of a certain province by applying and comparing 6 forecasting algorithms like LASSO regression, rigid regression, KNN, SVR, random forests, LSTM, with the historical power price and power load data generated during its real trial operation. The result of the nodal price forecasting shows that, in the case of taking historical nodal price as the only forecasting input, SVR performed the best forecasting accuracy and preferable generalization ability as well, while the LASSO regression performed the worst of which. While load data added in, the forecasting results run by SVR and LASSO regression reflected a significant improvement comparing -with other methods. In addition, SVR is also the most effective method of all. The improvement of the nodal price forecasting by adding load data partially depends on the forecasting model applied and the correlation of nodal price and the load data.

Published
2021
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64. Peak-shift Optimization Model and Pricing Strategies of Power Trading System in Bay Area

Author

Zhou Huafeng, Zhu Wen, Peng Chaoyi, Huijie Gu, Xu Danli, and Nie Yongquan

Subjects
Ecology, business.industry, Bidding, Environmental economics, Investment (macroeconomics), Grid, Port (computer networking), Electric power system, Pricing strategies, Economics, Electricity, business, Monopoly, Earth-Surface Processes, Water Science and Technology
Abstract

Zhu, W.; Gu, H.J.; Zhou, H.F.; Nie, Y.Q.; Peng, C.Y., and Xu, D.L., 2020. Peak-shift optimization model and pricing strategies of power trading system in bay area. In: Al-Tarawneh, O. and Megahed, A. (eds.), Recent Developments of Port, Marine, and Ocean Engineering. Journal of Coastal Research, Special Issue No. 110, pp. 34–37. Coconut Creek (Florida), ISSN 0749-0208.The rapid economic development in coastal areas is inseparable from the support of the power trading system. It also poses increasing demands for the power, which results in obvious peaks and troughs in daily power consumption, and causing distribution pressure and power dissipation of the transmission network. Based on the power trading model in Daya Bay area, this paper explores the peak shift optimization model in this coastal area, and establishes a new power trading model to eliminate the impact of power grid monopoly on electricity prices. The results show that the orderly power use in the bilateral trading model can effectively alleviate peak problems in the power trading system; pricing of power system cannot use market bidding, and it must be conducive to the development of high-voltage or ultra-high-voltage power, and also optimized investment by grid companies. The research findings provide a theoretical basis for the realization of power trading between supply and marketing parties.

Published
2020
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66. Utilization of polyacrylamide-thickening agent and aluminum sulfate liquid accelerator for improving early strength of Portland cement.

Author

Zhou, Huafeng, Zhang, Wan, Wu, Zhihong, Li, Chunmei, Huang, Wang, Wang, Jiawei, Pan, Yuexin, and Li, Zhishun

Subjects
*LIQUID aluminum, *ALUMINUM sulfate, *COMPRESSIVE strength, *THICKENING agents, *PORTLAND cement
Abstract

There is a problem that accelerator make the early compressive strength of mortar develop slowly. This study to utilize thickening agent and developed accelerator to improve the early compressive strength. The research findings demonstrated that with the addition of accelerator, a large amount of hydration products is formed in the paste. The dosage of PAH was 2%, the strength of the mortar reached 13.96 MPa at 1 d. The primary cause is that the PAH formed a granule-particle bridge structure, which made the structure of hydration products denser, thus improving the early compressive strength. It provides the value for the application of accelerator and thickener in the shotcrete field. [ABSTRACT FROM AUTHOR]

Published
2024
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68. Obeticholic acid demonstrates sustained improvements at month 24 in transaminases and non-invasive markers of fibrosis: results of a post hoc analysis from the interim analysis of the REGENERATE study

Author

Loomba, Rohit, primary, Ratziu, Vlad, additional, Anstee, Quentin, additional, Harrison, Stephen, additional, Sanyal, Arun, additional, Rinella, Mary, additional, Younossi, Zobair, additional, Goodman, Zachary, additional, Bedossa, Pierre, additional, Shringarpure, Reshma, additional, Zhou, Huafeng, additional, Venugopal, Aditya, additional, and Noureddin, Mazen, additional

Published
2020
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71. On-line PMU-based transmission line parameter identification

Author

Chaoyang Jing, Zhou Huafeng, Zhao Xuanyu, Chris Jones, Zhao Huashi, and Di Shi

Subjects
Engineering, business.industry, Impedance parameters, Electronic, Optical and Magnetic Materials, Conductor, Identification (information), General Energy, Dimension (vector space), Transmission line, Metric (mathematics), Line (geometry), Electronic engineering, Electrical and Electronic Engineering, business, Transmission tower
Abstract

China Southern Power Grid Company (CSG) recently developed and implemented an online PMU-based transmission line (TL) parameter identification system (TPIS). Traditionally, TL parameters are calculated based on transmission tower geometries, conductor dimension, estimates of line length, conductor sags, etc. These parameters only approximate the effect of conductor sag and ignore the dependence of impedance parameters on temperature variation. Recent development in PMU technology has made it possible to calculate TL parameters accurately. The challenges are that such an application requires highly accurate PMU data while the accuracy of PMU measurements under different working/system conditions can be uncertain. With a large number of PMUs widely installed in its system, CSG plans to improve and update the EMS database using the newly developed TPIS. TPIS provides an innovative yet practical problem formulation and solution for TL parameter identification. In addition, it proposes a new metric that can be used to determine the credibility of the calculated parameters, which is missing in the literature. This paper discusses the methodologies, challenges, as well as implementation issues noticed during the development of TPIS.

Published
2015
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76. Relationship of JAK2V617F Allelic Burden (AB) to Demographics, Disease Characteristics, and Response to Therapy in Persist-1, a Randomized Phase III Study of Pacritinib (PAC) Versus Best Available Therapy (BAT) in Patients (pts) with Primary and Secondary Myelofibrosis (MF)

Author

Vannucchi, Alessandro M., primary, Mead, Adam, additional, Egyed, Miklos, additional, Szoke, Anita, additional, Suvorov, Aleksandr, additional, Perkins, Andrew, additional, Mayer, Jiri, additional, Ganly, Peter, additional, Schouten, Harry C., additional, Tosi, Patrizia, additional, Farber, Charles Michael, additional, Zachee, Pierre, additional, Kiladjian, Jean-Jacques, additional, Nangalia, Jyoti, additional, Dean, James P., additional, Zhou, Huafeng, additional, Singer, Jack W., additional, Mesa, Ruben A., additional, and Harrison, Claire N., additional

Published
2016
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77. Calculating sequence impedances of transmission line using PMU measurements

Author

Zhao Huashi, Di Shi, Zhou Huafeng, Zhao Xuanyu, and Chaoyang Jing

Subjects
Engineering, Electric power transmission, Bootstrapping (electronics), Noise (signal processing), Estimation theory, business.industry, Transmission line, Metric (mathematics), Impedance matching, Electronic engineering, business, Electrical impedance
Abstract

An online transmission line (TL) impedance parameter identification system (TPIS) using PMU measurements was recently developed and implemented at China Southern Power Grid Company (CSG). Traditional approaches for TL impedance calculation only approximate the effect of conductor sags and ignore the dependence of impedances on temperature variation. Utilizing PMU measurements may improve the accuracy of TL parameters calculation. The challenge is that the parameters identified are very sensitive to noise and errors in PMU measurements, which are difficult to quantify and can be uncertain under different system operating/loading condition. TPIS provides an innovative yet practical problem formulation for TL sequence parameter estimation based on least-squares with linear constraints. A bootstrapping-based resampling technique is developed and a new metric is proposed to determine the credibility of the estimated sequence impedances. This paper discusses the proposed methodologies, challenges, as well as implementation issues identified during the development of TPIS.

Published
2015
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78. Influence of diamond-like carbon coatings and micro-texturing on friction and wear of seal interfaces: Experiment and simulation study

Author

He, Weilin, Ahmat, Mutellip, Zhou, Huafeng, Li, Zhenhua, Qiu, Wei, and Li, Duanzheng

Abstract

For mechanical seal friction vice in dry friction conditions, due to friction wear serious failure, is the slurry pump and other instruments in the operation of the process of the urgent need to solve the problem. In this paper, in order to optimize and enhance the friction and wear problem of mechanical seal end face of slurry pump. Surface treatment of mechanical sealing rings with diamond-like carbon (DLC) coating and surface microtexturing, and at different rotational speeds and normal forces, the surface hardness, wear coefficient and dry friction coefficient of the sealing rings were analyzed by experimental comparison, and the wear morphology was collected by electron microscopy, having analyzed the results of the sets of, the end face structure of the mechanical seal was optimized. Based on Archard wear model simulation calculations, the seal ring wear depth and wear quality were obtained. The results show: under dry friction conditions, the synergistic effect of the DLC coating and the surface micro-texture (MT), the coefficient of friction is reduced by approx. 68% and the quality and depth of wear is minimized. Excessive speeds and normal forces are more prone to wear behavior caused by abrasive wear. Simulation results of surface treatment groups, DLC / MT group maximum wear depth is the smallest; wear quality test and simulation of the maximum error within 15.7%. The results of the study can provide a basis for a phosphoric acid plant slurry pump mechanical seal design.

Published
2024
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79. Pacritinib (PAC) vs best available therapy (BAT) in myelofibrosis (MF): Outcomes in patients (pts) with baseline (BL) thrombocytopenia.

Author

Harrison, Claire N., Egyed, Miklos, Szoke, Anita, Suvorov, Aleksandr, Perkins, Andrew, Mayer, Jiri, Ganly, Peter, Schouten, Harry C., Tosi, Patrizia, Farber, Charles Michael, Zachee, Pierre, Scheid, Christof, Dean, James P., Zhou, Huafeng, Kiladjian, Jean -Jacques, Vannucchi, Alessandro M., Nangalia, Jyoti, Mead, Adam, Mesa, Ruben A., Harrison, Claire N., Egyed, Miklos, Szoke, Anita, Suvorov, Aleksandr, Perkins, Andrew, Mayer, Jiri, Ganly, Peter, Schouten, Harry C., Tosi, Patrizia, Farber, Charles Michael, Zachee, Pierre, Scheid, Christof, Dean, James P., Zhou, Huafeng, Kiladjian, Jean -Jacques, Vannucchi, Alessandro M., Nangalia, Jyoti, Mead, Adam, and Mesa, Ruben A.

Published
2016

80. Outcomes in patients with myelofibrosis and RBC-transfusion dependence in the phase III PERSIST-1 study of pacritinib vs. best available therapy.

Author

Harrison, Claire N., Egyed, Miklos, Szoke, Anita, Suvorov, Aleksandr, Perkins, Andrew, Mayer, Jiri, Ganly, Peter, Schouten, Harry C., Tosi, Patrizia, Farber, Charles Michael, Zachee, Pierre, Scheid, Christof, Dean, James P., Zhou, Huafeng, Kiladjian, Jean-Jacques, Vannucchi, Alessandro M., Nangalia, Jyoti, Mead, Adam, Mesa, Ruben A., Harrison, Claire N., Egyed, Miklos, Szoke, Anita, Suvorov, Aleksandr, Perkins, Andrew, Mayer, Jiri, Ganly, Peter, Schouten, Harry C., Tosi, Patrizia, Farber, Charles Michael, Zachee, Pierre, Scheid, Christof, Dean, James P., Zhou, Huafeng, Kiladjian, Jean-Jacques, Vannucchi, Alessandro M., Nangalia, Jyoti, Mead, Adam, and Mesa, Ruben A.

Published
2016

84. Pacritinib (PAC) vs best available therapy (BAT) in myelofibrosis (MF): Outcomes in patients (pts) with baseline (BL) thrombocytopenia.

Author

Harrison, Claire N., primary, Egyed, Miklos, additional, Szoke, Anita, additional, Suvorov, Aleksandr, additional, Perkins, Andrew, additional, Mayer, Jiri, additional, Ganly, Peter, additional, Schouten, Harry C., additional, Tosi, Patrizia, additional, Farber, Charles Michael, additional, Zachee, Pierre, additional, Scheid, Christof, additional, Dean, James P., additional, Zhou, Huafeng, additional, Kiladjian, Jean-Jacques, additional, Vannucchi, Alessandro M., additional, Nangalia, Jyoti, additional, Mead, Adam, additional, and Mesa, Ruben A., additional

Published
2016
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85. Outcomes in patients with myelofibrosis and RBC-transfusion dependence in the phase III PERSIST-1 study of pacritinib vs. best available therapy.

Author

Harrison, Claire N., primary, Egyed, Miklos, additional, Szoke, Anita, additional, Suvorov, Aleksandr, additional, Perkins, Andrew, additional, Mayer, Jiri, additional, Ganly, Peter, additional, Schouten, Harry C., additional, Tosi, Patrizia, additional, Farber, Charles Michael, additional, Zachee, Pierre, additional, Scheid, Christof, additional, Dean, James P., additional, Zhou, Huafeng, additional, Kiladjian, Jean-Jacques, additional, Vannucchi, Alessandro M., additional, Nangalia, Jyoti, additional, Mead, Adam, additional, and Mesa, Ruben A., additional

Published
2016
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89. Safety analysis by UGT1A1 status of TROPHY-U-01 cohort 1, a phase 2 study of sacituzumab govitecan (SG) in patients (pts) with metastatic urothelial cancer (mUC) who progressed after platinum (PT)-based chemotherapy and a checkpoint inhibitor (CPI).

Author

Loriot, Yohann, Petrylak, Daniel P., Rezazadeh, Arash, Flechon, Aude, Jain, Rohit K., Gupta, Sumati, Bupathi, Manojkumar, Beuzeboc, Philippe, Palmbos, Phillip Lee, Kyriakopoulos, Christos, Pouessel, Damien, Sternberg, Cora N., Tonelli, Julia, Sierecki, Mitch, Zhou, Huafeng, Grivas, Petros, Barthelemy, Philippe, Balar, Arjun Vasant, and Tagawa, Scott T.

Published
2023
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90. Research and development of Operation Smart System in CSG

Author

Zhou Huafeng, Xiaochen Wu, and Jifeng Wang

Subjects
Smart system, Service (systems architecture), Engineering, business.industry, media_common.quotation_subject, Control (management), Power (physics), Data sharing, Development (topology), Embedded system, Conceptual model, Systems engineering, Architecture, business, media_common
Abstract

The paper summarizes the development and operation of the technical supporting systems in control centers and substations of China Southern Power Grid (CSG). Smart applications can be, based on functional integration and data sharing, developed for the operation of complicated power grids. A brand new conceptual model of next generation smart system, named Operation Smart System (OS2), is proposed. OS2 consists of the systems in all levels of control centers and substations of CSG, and the systems are linked with open and standardized service buses, called Operation Service Bus (OSB). The definition, principles, technical architecture, modules, and development of OS2 are discussed in detail.

Published
2012
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91. Pulmonary hypertension in idiopathic pulmonary fibrosis with mild-to-moderate restriction

Author

Raghu, Ganesh, primary, Nathan, Steven D., additional, Behr, Juergen, additional, Brown, Kevin K., additional, Egan, James J., additional, Kawut, Steven M., additional, Flaherty, Kevin R., additional, Martinez, Fernando J., additional, Wells, Athol U., additional, Shao, Lixin, additional, Zhou, Huafeng, additional, Henig, Noreen, additional, Szwarcberg, Javier, additional, Gillies, Hunter, additional, Montgomery, Alan B., additional, and O'Riordan, Thomas G., additional

Published
2015
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100. Diagnosis of idiopathic pulmonary fibrosis with high-resolution CT in patients with little or no radiological evidence of honeycombing: secondary analysis of a randomised, controlled trial

Author

Raghu, Ganesh, primary, Lynch, David, additional, Godwin, J David, additional, Webb, Richard, additional, Colby, Thomas V, additional, Leslie, Kevin O, additional, Behr, Juergen, additional, Brown, Kevin K, additional, Egan, James J, additional, Flaherty, Kevin R, additional, Martinez, Fernando J, additional, Wells, Athol U, additional, Shao, Lixin, additional, Zhou, Huafeng, additional, Pedersen, Patricia S, additional, Sood, Rohit, additional, Montgomery, A Bruce, additional, and O'Riordan, Thomas G, additional

Published
2014
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