65 results on '"Zhi-Xuan Li"'
Search Results
52. Hypoxia triggers the outbreak of infectious spleen and kidney necrosis virus disease through viral hypoxia response elements
- Author
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Jian He, Yang Yu, Zhi-Min Li, Zhi-Xuan Liu, Shao-Ping Weng, Chang-Jun Guo, and Jian-Guo He
- Subjects
Iridovirus ,ISKNV ,hypoxia ,hypoxia response elements ,HIF pathway ,Infectious and parasitic diseases ,RC109-216 - Abstract
Hypoxia frequently occurs in aquatic environments, especially in aquaculture areas. However, research on the relationship between hypoxic aquatic environments with viral diseases outbreak is limited, and its underlying mechanisms remain elusive. Herein, we demonstrated that hypoxia directly triggers the outbreak of infectious spleen and kidney necrosis virus (ISKNV) disease. Hypoxia or activated hypoxia-inducible factor (HIF) pathway could remarkably increase the levels of viral genomic DNA, titers, and gene expression, indicating that ISKNV can response to hypoxia and HIF pathway. To reveal the mechanism of ISKNV respond to HIF pathway, we identified the viral hypoxia response elements (HREs) in ISKNV genome. Fifteen viral HREs were identified, and four related viral genes responded to the HIF pathway, in which the hre-orf077r promoter remarkably responded to the HIF pathway. The level of orf077r mRNA dramatically increased after the infected cells were treated with dimethyloxalylglycine (DMOG) or the infected cells/fish subjected to hypoxic conditions, and overexpressed orf077r could remarkably increase the ISKNV replication. These finding shows that hypoxic aquatic environments induce the expression of viral genes through the viral HREs to promote ISKNV replication, indicating that viral HREs might be important biomarkers for the evaluation of the sensitivity of aquatic animal viral response to hypoxia stress. Furthermore, the frequencies of viral HREs in 43 species aquatic viral genomes from 16 families were predicted and the results indicate that some aquatic animal viruses, such as Picornavirdea, Dicistronviridae, and Herpesviridae, may have a high risk to outbreak when the aquatic environment encounters hypoxic stress.
- Published
- 2022
- Full Text
- View/download PDF
53. Three-dimensional numerical simulation of electromagnetic diffusion problem and magnetization effects
- Author
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Ming-Xin Yue, Zhi-Xuan Li, and Guan-Qun Zhou
- Subjects
Physics ,Magnetization ,Computer simulation ,Diffusion problem ,General Physics and Astronomy ,Mechanics - Abstract
We present a newly developed algorithm for three-dimensional (3D) magnetotelluric model based on the vector finite element method. In this paper, unstructured grids which are composed of irregular tetrahedrons are used in our finite element model, which can be refined locally and adaptively according to the complex geometry of computational domain or subsurface structure. For obtaining more accurate solutions, secondary field rather than total field is numerically computed, which makes the errors limited to relatively small secondary field. Traditional node-based finite element method does not satisfy the condition that the normal electrical field is discontinuous at the interface of electric separatrix and the electrical current density is divergence-free throughout the regions without source, which obviously violates Maxwell equations. In order to overcome these drawbacks of node-based finite element, vector finite element method is employed to solve the secondary field-based partial differential equation. Moreover, in this study, the heterogeneous permeability is taken into consideration in our algorithm, as a consequence, which can deal with heterogeneous permeability model. The accuracy of our approach is verified by comparing with previously published numerical simulations of a COMMEMI-3D model. The advantages of our approach are also illustrated by the numerical simulations of model with arbitrary topography and complicated anomalous body. In addition, the simulation results of the irregular anomaly and the complex model of arbitrary terrain are both ideal results. It proves that the effect of 3D terrain is more serious and complex than that of two-dimensional (2D) terrain, and dealing with 3D models or data with 2D algorithm may bring in large errors. In the area where the magnetic permeability is abnormal, the magnetic permeability has an important influence on the numerical simulation results, and the magnetic permeability must be treated as an independent parameter in the magnetotellurics survey.
- Published
- 2019
54. Analysis of a 66kV Transformer Insulation Breakdown Accident
- Author
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Chuan Bo Liu, Qing Hao Wang, Hua Zhang, Zhi Xuan Li, Ping Li, Ning Zhang, and Xiao Yu Cui
- Subjects
Isolation transformer ,Engineering ,business.industry ,Flyback transformer ,Electrical engineering ,General Medicine ,Structural engineering ,Distribution transformer ,Lightning arrester ,law.invention ,law ,Energy efficient transformer ,business ,Delta-wye transformer ,Transformer ,Transformer effect - Abstract
The total reflection of the wave will occur twice and the lightning over-voltage will be increased by 2 times when the lightning wave along the line reached in the disconnect switch are derived through the analysis of the accident 66kV transformer insulation breakdown. This will lead to the switch breakdown and discharge to be grounded. In this case the breaker is between the arrester and the transformer and the transformer will withstand 2 times arrester residual voltage result in the transformer breakdown. Finally, effective preventive measures combined with the practical experience are proposed.
- Published
- 2013
55. A compact low-power VLSI architecture for real-time sleep stage classification
- Author
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Roman Genov, Peter Zhi Xuan Li, and Hossein Kassiri
- Subjects
Engineering ,business.industry ,020208 electrical & electronic engineering ,02 engineering and technology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Filter (video) ,Microsystem ,Brain stimulation ,0202 electrical engineering, electronic engineering, information engineering ,State (computer science) ,Sleep (system call) ,Sensitivity (control systems) ,Latency (engineering) ,business ,Field-programmable gate array ,Computer hardware - Abstract
A wearable-optimized implementation of a sleep stage classification algorithm that has low detection latency, high detection accuracy and low resource consumption is developed and successfully implemented on a low-power FPGA microsystem for closed-loop electrical brain stimulation. This implementation uses EEG and EMG signals as inputs and classifies stages of sleep. By structurally merging multichannel FIR and window averaging filters into one reconfigurable, multipurpose filter, the new implementation maintains a sleep detection accuracy of 79.7%, a REM detection sensitivity of 98.2%, a REM detection specificity of 89.2% and a detection latency of 0.982 ms, while consuming 6.8 times fewer logic elements and 96.28% less power compared with the current state of the art implementation. With its high performance and low resource usage, this implementation enables a low-power wearable microsystem to perform neural recording, real-time REM sleep stage detection, and closed-loop responsive brain stimulation as a tool to study the mechanisms of neurodegenerative diseases.
- Published
- 2016
56. Study of the Minimization of Instantaneous Equivalent Fuel Consumption Control Strategy of HEV
- Author
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Peng Yu Wang, Qing Nian Wang, Qing Lin Zhu, and Zhi Xuan Li
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Battery (electricity) ,Engineering ,business.industry ,General Engineering ,Control engineering ,Computer Science::Hardware Architecture ,Software ,Regenerative brake ,Control theory ,Range (aeronautics) ,Fuel efficiency ,Penalty method ,Minification ,business ,Computer Science::Operating Systems ,Energy (signal processing) - Abstract
A control strategy which based on minimum instantaneous equivalent fuel consumption was proposed in this paper. The important parameters that affected the calculation of instantaneous fuel consumption were analyzed. The important parameters include battery equivalent fuel consumption, penalty function to maintain the battery SOC and the revise of the regenerative braking energy. More precise expression of minimum instantaneous fuel consumption was deduced. Under the simulation platform of ADVISOR software, orthogonal optimization of parameters was performed and the range of important parameters in the optimization of expression was determined.
- Published
- 2012
57. The Research on Deposition Saturation of Disc Suspension Porcelain Insulator
- Author
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Zhi Xuan Li, Qing Hao Wang, Tian Shu Hai, Hu Yang, Shao Yong Wu, Feng Shi, Peng Fei Cheng, Dong Wei Huang, Chang Xin Ge, and Shuo Cheng
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Condensed Matter::Quantum Gases ,Materials science ,General Engineering ,Electronic engineering ,Condensed Matter::Strongly Correlated Electrons ,Insulator contamination ,Insulator (electricity) ,Porcelain insulator ,Composite material ,Saturation (chemistry) ,Salt deposit density - Abstract
The equivalent salt deposit density (ESDD) is an important characteristic of our country which is used to measure insulator deposition level. The contamination of the insulator would reach saturation after a period of time.In order to increase the specific creepage distance, disc suspension porcelain insulator lower surface inward concave, which makes the rain washing the upper surface difficult, that cause the saturation time of lower surface longer than upper surface .For studying the operation insulator contamination saturation time and reflecting the ESDD of the actual operation line accurately,this paper adopts a comparison method between empty hanging insulator surface and operation insulator surface to measure the ESDD , the field experimental results further verify that the saturated time of disc suspension insulator lower surface is longer, so as to lay the foundation for the ESDD measurement.
- Published
- 2014
58. Application Research on High-Tech Tax Preference Policy of Manufacturing
- Author
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Shu Fen Cui, Zhi Xuan Li, and Min Du
- Subjects
Double taxation ,ComputingMilieux_LEGALASPECTSOFCOMPUTING ,General Medicine ,Tax reform ,Turnover tax ,ComputingMilieux_GENERAL ,Value-added tax ,Ad valorem tax ,Tax credit ,State income tax ,Business ,ComputingMilieux_MISCELLANEOUS ,Industrial organization ,Indirect tax - Abstract
This paper discusses the application research on high-tech tax preference policy of manufacturing. Analyzing high-tech tax preference policy of the current manufacturing;The disadvantages of high-tech tax preference policy in production manufacturing;Suggestions for further implementing the high-tech tax preference policy of manufacturing.
- Published
- 2013
59. Isolation and characterization of polymorphic microsatellite loci in Ping’s juniper Juniperus pingii
- Author
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Ma-Li Wang, Min-Feng Fang, Zhan-Lin Liu, Yu-Jin Wang, Gui-Fang Zhao, Zhonghu Li, and Zhi-Xuan Li
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Genetics ,Genetic diversity ,Linkage disequilibrium ,education.field_of_study ,biology ,Population ,Juniperus pingii ,Population genetics ,Locus (genetics) ,biology.organism_classification ,Microsatellite ,Juniper ,education ,Ecology, Evolution, Behavior and Systematics - Abstract
Juniperus pingii (Ping's juniper) is a threatened conifer species endemic to China, and a good knowledge of its population genetics would be essential to formulate effective conservation strategies. In this study, ten polymorphic microsatellite loci were isolated, and characterized for their utility using 58 individuals from two geographically distinct populations. In population XGLL, the number of alleles per locus (N (A)) ranged from four to 11, with an average of 6.2 per locus; the observed (H (O)) and expected heterozygosity (H (E)) ranged from 0.205 to 0.854 and from 0.423 to 0.754, with an average of 0.347 and 0.527, respectively. In population BM, N (A), H (O) and H (E) ranged from four to eight, from 0.198 to 0.454 and from 0.339 to 0.853, with an average of 5.8, 0.294 and 0.556, respectively. Following the sequential Bonferroni correction, only one locus (Jp07) was found to deviate significantly from Hardy-Weinberg equilibrium within population XGLL, and no significant linkage disequilibrium was detected in any of these loci within either population. These polymorphic microsatellite loci would be useful for population genetic studies of this conifer species.
- Published
- 2013
60. A digital pulsar backend based on FPGA
- Author
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Ali Esamdin, Zhi-Xuan Li, Lan Chen, Jin-Lin Han, Longfei Hao, Xiuzhong Zhang, Jintao Luo, and Yajun Wu
- Subjects
Physics ,L band ,Astrophysics::High Energy Astrophysical Phenomena ,Bandwidth (signal processing) ,Astrophysics::Instrumentation and Methods for Astrophysics ,Astronomy ,Astronomy and Astrophysics ,Astrophysics ,01 natural sciences ,law.invention ,Telescope ,Pulsar ,Space and Planetary Science ,Observatory ,Millisecond pulsar ,law ,0103 physical sciences ,S band ,010306 general physics ,Field-programmable gate array ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
A digital pulsar backend based on a Field Programmable Gate Array (FPGA) is developed. It is designed for incoherent de-dispersion of pulsar observations and has a maximum bandwidth of 512 MHz. The channel bandwidth is fixed to 1 MHz, and the highest time resolution is 10 μs. Testing observations were carried out using the Urumqi 25-m telescope administered by Xinjiang Astronomical Observatory and the Kunming 40-m telescope administered by Yunnan Observatories, targeting PSR J0332+5434 in the L band and PSR J0437–4715 in the S band, respectively. The successful observation of PSR J0437–4715 demonstrates its ability to observe millisecond pulsars.
- Published
- 2017
61. VLBI Observation of Pulsar B0329+54 with the CVN at S/X Bands
- Author
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Wen, Chen, primary, Wu, Jiang, additional, Zhi-xuan, Li, additional, Yong-hua, Xu, additional, and Min, Wang, additional
- Published
- 2016
- Full Text
- View/download PDF
62. Comparative Genomics Analysis and Outer Membrane Vesicle-Mediated Horizontal Antibiotic-Resistance Gene Transfer in Avibacterium paragallinarum
- Author
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Jie Xu, Chen Mei, Yan Zhi, Zhi-xuan Liang, Xue Zhang, and Hong-jun Wang
- Subjects
A. paragallinarum ,outer membrane vesicles ,whole genome ,antibiotic resistance gene ,horizontal gene transfer ,Microbiology ,QR1-502 - Abstract
ABSTRACT Avibacterium paragallinarum is the etiological agent of infectious coryza, an acute respiratory disease of chickens that is globally distributed and causes serious economic losses for chicken production. A. paragallinarum is a Gram-negative bacterium that releases outer membrane vesicles (OMVs). In this study, a comparative genomic analysis of A. paragallinarum isolate P4chr1 and its OMVs was carried out, and the ability to transfer antibiotic resistance genes (ARGs) via the OMVs was studied. Sequencing and data analyses demonstrated that the genomic size of A. paragallinarum P4chr1 was approximately 2.77 Mb with a 25 kb tolerance island that covered six types of antibiotics and 11 ARGs. The genomic size of its OMVs was approximately 2.69 Mb, covering 97% of the genomic length and almost all the gene sequences of P4chr1. Purified and DNase-treated A. paragallinarum P4chr1 OMVs were cocultured with the antibiotic-sensitive A. paragallinarum Modesto strain on an antibiotic (chloramphenicol, erythromycin, tetracycline, or streptomycin)-containing plate, and the corresponding ARGs were detected in the colonies grown on the plates. However, using an antimicrobial susceptibility test, we found that ARGs delivered by OMVs were not persistent but only appeared transiently on the antibiotic-containing plates. Antibiotic resistance and ARGs were lost by the second bacterial passage. IMPORTANCE The functions and roles of OMVs on ARG and virulent gene transfer and dissemination have been reported in numerous Gram-negative bacteria. However, the role of OMVs in mediating antibiotic resistance in A. paragallinarum has not been reported. This study is the first report to compare the genomic characteristics of OMVs with its parent A. paragallinarum strain and to study A. paragallinarum ARG transfer via OMVs. This work has provided useful data for further studies focusing on nonplasmid ARG transfer mediated by A. paragallinarum OMVs.
- Published
- 2022
- Full Text
- View/download PDF
63. Three antinematodal diterpenes from Euphorbia kansui
- Author
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Zhi Xuan Li, Shuhei Nakajima, Hiroshi Kanzaki, Naomichi Baba, Minoru Izumi, Jian Xiao Shi, Kazuyoshi Kawazu, and Teruhiko Nitoda
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Models, Molecular ,Spectrometry, Mass, Electrospray Ionization ,Magnetic Resonance Spectroscopy ,Spectrophotometry, Infrared ,diterpenoid ,Bursaphelenchus xylophilus ,ingenane ,Spectrometry, Mass, Fast Atom Bombardment ,Applied Microbiology and Biotechnology ,Biochemistry ,Plant Roots ,Analytical Chemistry ,Euphorbia ,Botany ,Molecular Biology ,Traditional medicine ,biology ,antinematodal activity ,Antinematodal Agents ,Organic Chemistry ,General Medicine ,biology.organism_classification ,Euphorbia kansui ,Nematode ,Indicators and Reagents ,Spectrophotometry, Ultraviolet ,Chromatography, Thin Layer ,Diterpenes ,Biotechnology - Abstract
Three compounds, 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol (1), 20-O-acetyl-[5-O-(2'E,4'Z)-decadienoyl]-ingenol (2) and 3-O-(2'E,4'Z)-decadienoylingenol (3), were isolated from Euphorbia kansui under the bioassay-guided method. Each compound showed the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball.
- Published
- 2007
64. Three Antinematodal Diterpenes from Euphorbia kansui.
- Author
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Jian-Xiao Shi, Zhi-Xuan Li, Nitoda, Teruhiko, Izumi, Minoru, Kanzaki, Hiroshi, Baba, Naomichi, Kawazu, Kazuyoshi, and Nakajima, Shuhei
- Subjects
- *
EUPHORBIA , *NEMATODES , *PINEWOOD nematode , *ALCOHOL , *EUPHORBIACEAE - Abstract
The article describes the isolation and structural characterization of three antinematodal compounds from Euphorbia kansui against the nematode, Bursaphelenchus xylophilus. The compounds include 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol, 20-O-acetyl-[5-O-(2'E,4'Z)-decadienoyl]-ingenol and 3-O-(2'E,4'Z)-decadienoylingenol. According to the authors, each compound showed the same antinematodal activity against the nematode at a minimum effective dose of 5µg/cotton ball.
- Published
- 2007
- Full Text
- View/download PDF
65. A digital pulsar backend based on FPGA.
- Author
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Jin-Tao Luo, Lan Chen, Jin-Lin Han, Ali Esamdin, Ya-Jun Wu, Zhi-Xuan Li, Long-Fei Hao, and Xiu-Zhong Zhang
- Published
- 2017
- Full Text
- View/download PDF
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