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Background: Despite promising overall survival of stage I lung adenocarcinoma (LUAD) patients, 10-25 % of them still went through recurrence after surgery. [1] While it is still disputable whether adjuvant chemotherapy is necessary for stage I patients. [2] IASLC grading system for non-mucinous LUAD shows that minor high-grade patterns are significant indicator of poor prognosis. [3] Other risk factors, such as, pleura invasion, lympho-vascular invasion, STAS, etc. are also related to poor prognosis. [4-6] There still lack evidence whether IASLC grade itself or together with other risk factors can guide the use of adjuvant therapy in stage I patients. In this article, we tried to establish a multi-variable recurrence prediction model for stage I LUAD patients that is able to identify candidates of adjuvant chemotherapy. Methods: We retrospectively collected patients who underwent lung surgery from 2018.8.1 to 2018.12.31 at our institution and diagnosed with lung adenocarcinoma pT1-2aN0M0 (stage I). Clinical data, manifestation on CT scan, pathologic features, driver gene mutations and follow-up information were collected. Cox proportional hazards regression analyses were performed utilizing the non-adjuvant cohort to predict disease free survival (DFS) and a nomogram was constructed and applied to the total cohort. Kaplan-Meier method was used to compare DFS between groups. Statistical analysis was conducted by R version 3.6.3. Findings: A total of 913 stage I LUAD patients were included in this study. Median follow-up time is 48.1 months.4-year and 5-year DFS are 92.9 % and 89.6 % for the total cohort. 65 patient experienced recurrence or death. 4-year DFS are 97.0 %,94.6 % and 76.2 %, and 5-year DFS are 95.5 %, 90.0 % and 74.1 % in IASLC Grade1, 2 and 3, respectively(p < 0.0001). High-risk patients defined by single risk factors, such as, IASLC grade 3, pleura invasion, STAS, less LN resected could not benefit from adjuvant therapy. A LASSO-COX regression model was built and patients are divided into high-risk and low-risk groups. In the high-risk group, patients underwent adjuvant chemotherapy have longer DFS than those who did not (p = 0.024), while in the low-risk group, patients underwent adjuvant chemotherapy have inferior DFS than those who did not (p < 0.001). Interpretation: IASLC grading is a significant indicator of DFS, however it could not guide adjuvant therapy in our stage I LUAD cohort. Growth patterns and T indicators together with other risk factors could identify high-risk patients that are potential candidate of adjuvant therapy, including some stage IA LUAD patients.

The effects of key parameters on locked mode induced disruption (LMiD) are investigated in EAST experiments. The experimental data for locked mode are collected from 2015 to 2022 when the externally applied resonant magnetic perturbation is successfully employed in EAST. In this dataset, ∼42% of the total shots are LMiD, while the remaining 58% are LM without disruption. To better analyze the LMiD, an intuitive physical process is proposed. The LMiD process can be divided into two stages, the evolution of magnetic islands and the loss of plasma stored energy. The LMiD can also be related to the evolution of the other 8 physical quantities. On the basis of this physical process analysis, the time scale and the influencing factors for LMiD are investigated using statistical analysis. It is found that the density (ne), the distance from the magnetic island outer boundary to the plasma last closed surface (dedge), the loop-voltage (Vloop), and the plasma core electron temperature (Te), which are consistent with the intuitive physical model, are key parameters to LMiD. In addition, other potentially important parameters, the relevant reasons, and statistical analysis on the parameter intervals where rapid disruption with greater harmfulness occurred have also been investigated.

This paper summarized the Traditional Chinese Medicine (TCM) nursing of a patient with postoperative pain after surgery for breast cancer. The patient had received a comprehensive nursing assessment after hospital admission. Based on the TCM syndrome differentiation, appropriate technique of TCM nursing including TCM ointment massage, cupping therapy, TCM medication and emotional care were carried out to relieve the negative emotion and postoperative pain of the patient. (本文总结1例乳腺癌患者术后疼痛的中医状态调护经验。患者入院后完善护理评估, 基于中医辨证, 采取中药膏摩、拔罐疗法、口服中药、情志护理等中医护理适宜技术干预, 有效改善患者负性情绪, 减轻疼痛, 有助于提高肿瘤患者生存质量。)

Abstract Background Previous evidence suggests that higher blood uric acid (UA) levels are associated with adverse cardiovascular outcomes during pregnancy and subsequent birth outcomes. However, it has been relatively unclear whether these associations persist in normotensive pregnant women. Methods The study was based on a retrospective analysis of 18,250 mother-infant pairs in a large obstetric center in China. Serum UA concentrations in early pregnancy (median: 17.6, IQR: 16.3, 18.6 gestational weeks) were assessed. Hyperuricemia was defined as ≥ one standard deviation (SD) of the reference value for the corresponding gestational age. Outcomes of gestational diabetes mellitus (GDM), preterm birth (PB), low birth weight (LBW), macrosomia, small for gestational age (SGA) and large for gestational age (LGA) were extracted from the medical records. Results The mean maternal UA level was 0.22 ± 0.05 mmol/L, and 2,896 (15.9%) subjects had hyperuricemia. After adjustment for several covariates, UA was associated with several adverse outcomes. The ORs (95%CI) per one SD increase in serum UA concentration were 1.250 (1.136, 1.277) for GDM, 1.137 (1.060, 1.221) for PB, 1.134 (1.051, 1.223) for LBW, and 1.077 (1.020, 1.137) for SGA, respectively. Similar adverse associations were found between hyperuricemia and GDM, PB (ORs: 1.394 and 1.385, P

Objective To build a model of postoperative pathological fracture of the mandibular angular cystic lesions through 3D finite element analysis (FEA), to compare and analyze the biomechanical changes of the mandible after treatment with 8 types of titanium plates, and explore the reliability of titanium plate fixation in preventing pathological fracture of large mandibular cysts. Methods A 30-year-old healthy male was volunteered and the scans of cone beam computed tomography of his mandible were collected to establish a unilateral cystic lesion model of the mandibular angle region to mimic the pathological fracture caused by occlusal force loading. On the basis of the maximum critical cystic lesion size, the biomechanical characteristics and changes in the mandible with 8 different types of titanium plate fixation under the same mechanical conditions were compared. Results The risk of pathological fracture existed when the cystic lesion size in the mandibular angle exceeds 24 mm×30 mm×30 mm. The stress in the lesion area was the lowest when the upper edge was fixed with 1 mm thick titanium plate and bilateral 3 screws, and the lower edge was fixed with 2 mm thick titanium plate and bilateral 4 screws. At the same time the maximum yield strength of the mandible was not exceeded and no pathological fracture of the mandible occurred. Conclusion The incidence of pathological fracture can be reduced by using titanium plate fixation on the upper and lower margins of the mandibular angle after extraoral surgical curettage for large cystic lesions.

To overcome the challenges of the increasing global energy and to solve the global energy & environment problems, process intensification is one way to develop new efficient production pathways for the chemical industry. Process intensification plays an important role in the gas-liquid mass transfer processes. This review provides an overview of the developments in gas-liquid mass transfer enhancement. A major enhancement method, namely introducing additives (including nanoparticles, oil, electrolyte, and surfactant) summarized and discussed here, includes the most recent accomplishments in gas-liquid mass transfer engineering. This review is expected to inspire new research for future developments and potential applications in scientific research and industry regarding gas-liquid mass transfer engineering. Finally, it presents conclusions and perspectives on enhancing gas-liquid mass transfer.

The COVID-19 infection belongs to the category of "blight" in Traditional Chinese Medicine. The course of illness is generally about 7 days, and the recovery period is crucial for COVID-19 patients. This paper comprehensively summarized the application of Traditional Chinese Medicine nursing in the recovery period of novel coronavirus infection from the aspects of moxibustion, exercise therapy, Traditional Chinese Medicine emotional therapy, acupoint massage, diet nursing, etc. , so as to provide reference for further research. (新型冠状病毒感染属于中医“疫病”范畴, 病程一般约7 d, 恢复期对于患者来说至关重要。本文从艾灸、运动调护、中医情志疗法、穴位按摩、饮食护理等方面总结了中医护理在新型冠状病毒感染恢复期的应用, 为进一步研究提供参考。)

In order to promote the inheritance innovation and development of Traditional Chinese Medicine nursing, the establishment of Traditional Chinese Medicine nursing veteran expert experience inheritance system and sharing platform, enhance the confidence of Traditional Chinese Medicine nursing culture. This article shared the contents of the establishment, forms and achievements of "Zheng Ping Traditional Chinese Medicine Inheritance Studio", in order to provide reference for Traditional Chinese Medicine nursing inheritance management mode. (为推动中医护理传承创新与发展, 建立中医护理老专家经验传承体系和共享平台, 提升中医护理文化自信。本文从“郑萍中医护理传承工作室”的建立、传承的形式及传承的成果等内容进行分享, 以期为中医护理传承管理模式提供参考借鉴。)

This paper extracted transcripts of conversational dialogues with Traditional Chinese Medicine nursing master Zheng Ping, and summarized Zheng Ping’s working and learning experience and her thinking on inheritance of Traditional Chinese Medicine nursing, and provided reference for learning and inheriting valuable experience. (本文通过整理中医护理传承导师郑萍访谈录, 总结传承导师郑萍的工作体会、学习经历、对中医护理传承的思考等内容, 为传承人学习和继承郑萍导师宝贵护理经验提供参考。)

This paper reviewed the research literature of clinical status medicine in the past ten years, summarized the theory of clinical status medicine, and discusses the Traditional Chinese Medicine nursing based on this theory in the future nursing circle, aiming to provide new ways and new ideas for clinical Traditional Chinese Medicine nursing practice. (回顾近十年来临床状态医学的研究文献, 对临床状态医学的理论进行综述, 对未来护理领域可基于该理论开展的状态调护内容进行探讨, 旨在为临床中医护理实践提供新理论、新途径、新思路。)