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66 results on '"Zhao, Renping"'

52. A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity

Author

Zhou, Xiao, primary, Friedmann, Kim S., additional, Lyrmann, Hélène, additional, Zhou, Yan, additional, Schoppmeyer, Rouven, additional, Knörck, Arne, additional, Mang, Sebastian, additional, Hoxha, Cora, additional, Angenendt, Adrian, additional, Backes, Christian S., additional, Mangerich, Carmen, additional, Zhao, Renping, additional, Cappello, Sabrina, additional, Schwär, Gertrud, additional, Hässig, Carmen, additional, Neef, Marc, additional, Bufe, Bernd, additional, Zufall, Frank, additional, Kruse, Karsten, additional, Niemeyer, Barbara A., additional, Lis, Annette, additional, Qu, Bin, additional, Kummerow, Carsten, additional, Schwarz, Eva C., additional, and Hoth, Markus, additional

Published
2018
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53. Human profilin 1 is a negative regulator of CTL mediated cell‐killing and migration

Author

Schoppmeyer, Rouven, primary, Zhao, Renping, additional, Cheng, He, additional, Hamed, Mohamed, additional, Liu, Chen, additional, Zhou, Xiao, additional, Schwarz, Eva C., additional, Zhou, Yan, additional, Knörck, Arne, additional, Schwär, Gertrud, additional, Ji, Shunrong, additional, Liu, Liang, additional, Long, Jiang, additional, Helms, Volkhard, additional, Hoth, Markus, additional, Yu, Xianjun, additional, and Qu, Bin, additional

Published
2017
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57. Reduction of the HIV Protease Inhibitor-Induced ER Stress and Inflammatory Response by Raltegravir in Macrophages

Author

Zhang, Xiaoxuan, primary, Cao, Risheng, additional, Liu, Runping, additional, Zhao, Renping, additional, Huang, Yi, additional, Gurley, Emily C., additional, Hylemon, Phillip B., additional, Pandak, William M., additional, Wang, Guangji, additional, Zhang, Luyong, additional, Li, Xiaokun, additional, and Zhou, Huiping, additional

Published
2014
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59. Abstract 4364: S1P generated by SphK1 is important not only for primary tumor growth but also for tumor-induced hemangiogenesis and lymphangiogenesis

Author

Nagahashi, Masayuki, primary, Ramachandran, Subramaniam, additional, Kim, Eugene Y., additional, Allegood, Jeremy C., additional, Rashid, Omar M., additional, Yamada, Akimitsu, additional, Zhao, Renping, additional, Milstien, Sheldon, additional, Zhou, Huiping, additional, Spiegel, Sarah, additional, and Takabe, Kazuaki, additional

Published
2012
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61. Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

Author

Nagahashi, Masayuki, primary, Ramachandran, Subramaniam, additional, Kim, Eugene Y., additional, Allegood, Jeremy C., additional, Rashid, Omar M., additional, Yamada, Akimitsu, additional, Zhao, Renping, additional, Milstien, Sheldon, additional, Zhou, Huiping, additional, Spiegel, Sarah, additional, and Takabe, Kazuaki, additional

Published
2012
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62. Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

Author

Studer, Elaine, primary, Zhou, Xiqiao, additional, Zhao, Renping, additional, Wang, Yun, additional, Takabe, Kazuaki, additional, Nagahashi, Masayuki, additional, Pandak, William M., additional, Dent, Paul, additional, Spiegel, Sarah, additional, Shi, Ruihua, additional, Xu, Weiren, additional, Liu, Xuyuan, additional, Bohdan, Pat, additional, Zhang, Luyong, additional, Zhou, Huiping, additional, and Hylemon, Phillip B., additional

Published
2011
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65. Interorganelle Tethering to Endocytic Organelles Determines Directional Cytokine Transport in CD4 + T Cells.

Author

Zhou Y, Zhao R, Schwarz EC, Akbar R, Kaba M, Pattu V, Helms V, Rieger H, Nunes-Hasler P, and Qu B

Subjects
Cell Line, Dyneins metabolism, Endosomes metabolism, HEK293 Cells, Humans, Kinesins metabolism, Lysosomes metabolism, Microtubules metabolism, Biological Transport physiology, CD4-Positive T-Lymphocytes metabolism, Cytokines metabolism, Endocytosis physiology, Organelles metabolism
Abstract

Delivery of vesicles to their desired destinations plays a central role in maintaining proper cell functionality. In certain scenarios, depending on loaded cargos, the vesicles have spatially distinct destinations. For example, in T cells, some cytokines (e.g., IL-2) are polarized to the T cell-target cell interface, whereas the other cytokines are delivered multidirectionally (e.g., TNF-α). In this study, we show that in primary human CD4 + T cells, both TNF-α + and IL-2 + vesicles can tether with endocytic organelles (lysosomes/late endosomes) by forming membrane contact sites. Tethered cytokine-containing vesicle (CytV)-endocytic organelle pairs are released sequentially. Only endocytic organelle-tethered CytVs are preferentially transported to their desired destination. Mathematical models suggest that endocytic organelle tethering could regulate the direction of cytokine transport by selectively attaching different microtubule motor proteins (such as kinesin and dynein) to the corresponding CytVs. These findings establish the previously unknown interorganelle tethering to endocytic organelles as a universal solution for directional cytokine transport in CD4 + T cells. Modulating tethering to endocytic organelles can, therefore, coordinately control directionally distinct cytokine transport., (Copyright © 2020 by The American Association of Immunologists, Inc.)

Published
2020
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66. CXCL16 induces angiogenesis in autocrine signaling pathway involving hypoxia-inducible factor 1α in human umbilical vein endothelial cells.

Author

Yu X, Zhao R, Lin S, Bai X, Zhang L, Yuan S, and Sun L

Subjects
Cell Movement genetics, Cell Proliferation genetics, Chemokine CXCL16, Chemokines, CXC genetics, Gene Expression Regulation, Neoplastic, Human Umbilical Vein Endothelial Cells metabolism, Human Umbilical Vein Endothelial Cells pathology, Humans, Hypoxia-Inducible Factor 1, alpha Subunit genetics, MAP Kinase Signaling System genetics, Neovascularization, Pathologic pathology, Proto-Oncogene Proteins c-akt genetics, Receptors, Scavenger genetics, Vascular Endothelial Growth Factor A biosynthesis, Vascular Endothelial Growth Factor A genetics, Autocrine Communication genetics, Chemokines, CXC biosynthesis, Hypoxia-Inducible Factor 1, alpha Subunit biosynthesis, Neovascularization, Pathologic genetics, Receptors, Scavenger biosynthesis
Abstract

Chemokine (C-X-C motif) ligand 16 (CXCL16) is a new angiogenic factor inducing angiogenesis via extracellular signal-regulated kinases pathway. To further understand the molecular mechanism underlying CXCL16‑induced angiogenesis, we explored involvement of other relevant pathways in CXCL16-induced angiogenesis. In the present study, we investigated the mechanisms underlying CXCL16-induced angiogenesis in human umbilical vein endothelial cells (HUVECs). CXCL16 promoted HUVEC proliferation, tube formation and migration. Enzyme-linked immunosorbent assay revealed that CXCL16 induced vascular endothelial growth factor secretion from HUVECs. Western blot analysis showed that CXCL16 increased the level of hypoxia‑inducible factor 1α, p-extracellular signal-regulated kinases (ERK), p-p38 and p-Akt dose- and time-dependently. ERK-, p38- and Akt-selective inhibitors significantly suppressed HUVEC proliferation, migration, tube formation and hypoxia-inducible factor 1α (HIF-1α) expression induced by CXCL16. Furthermore, CXCL16 peptides induced CXCL16 secretion via ERK, p38 and Akt pathways, which was suppressed by HIF-1α-selective inhibitor PX12. Our data suggest that CXCL16 induces angiogenesis in autocrine manner via ERK, Akt, p38 pathways and HIF-1α modulation.

Published
2016
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