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494 results on '"Zhao, Peipei"'

51. Secondary metabolites isolated from Penicillium christenseniae SD.84 and their antimicrobial resistance effects.

Author

Wang, Xinzhu, Meng, Qingzhou, Chen, Haiyan, Yin, Xin, Dai, Huanqin, Zhao, Peipei, Pan, Yang, Xia, Xuekui, and Zhang, Lixin

Subjects
METABOLITES, DRUG resistance in microorganisms, PENICILLIUM, METHICILLIN-resistant staphylococcus aureus
Abstract

A pair of new quinolone alkaloid enantiomers, (Ra)-(-)-viridicatol (1) and (Sa)-(+)-viridicatol (4), and seven known compounds, namely, 2, 3 and 5–9, were isolated from Penicillium christenseniae SD.84. The structures of 1 and 4 were determined using NMR and HRESIMS data. Theoretical calculations through CD and ECD confirmed 1 and 4 as a pair of enantiomers. The MIC values of 4 against Staphylococcus aureus and methicillin-resistant S. aureus were 12.4 and 24.7 μM, respectively, compound 1 had no inhibitory activity. Antimicrobial assays of 2, 3, and 5–7 showed a moderate activity against S. aureus and methicillin-resistant S. aureus. This study demonstrated the remarkable potential of Penicillium sp. to produce new drug-resistant leading compounds, thereby advancing the mining for new sources of antimicrobial agents. [ABSTRACT FROM AUTHOR]

Published
2024
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52. Architectural Style Classification Based on DNN Model

Author

Zhao, Peipei, Miao, Qiguang, Liu, Ruyi, Song, Jianfeng, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Lin, Zhouchen, editor, Wang, Liang, editor, Yang, Jian, editor, Shi, Guangming, editor, Tan, Tieniu, editor, Zheng, Nanning, editor, Chen, Xilin, editor, and Zhang, Yanning, editor

Published
2019
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62. Neutrophil extracellular traps are involved in the occurrence of interstitial lung disease in a murine experimental autoimmune myositis model.

Author

Bai, Ling, Zhu, Jiarui, Ma, Wenlan, Li, Feifei, Zhao, Peipei, and Zhang, Sigong

Subjects
MYOSITIS, INTERSTITIAL lung diseases, LEUCOCYTE elastase, PERTUSSIS toxin, NEUTROPHILS, IDIOPATHIC diseases, CELL-free DNA
Abstract

The excessive formation of neutrophil extracellular traps (NETs) has been demonstrated to be a pathogenic mechanism of idiopathic inflammatory myopathy (IIM)-associated interstitial lung disease (ILD). This study aimed to answer whether an experimental autoimmune myositis (EAM) model can be used to study IIM-ILD and whether NETs participate in the development of EAM-ILD. An EAM mouse model was established using skeletal muscle homogenate and pertussis toxin (PTX). The relationship between NETs and the ILD phenotype was determined via histopathological analysis. As NETs markers, serum cell-free DNA (cfDNA) and serum citrullinated histone 3 (Cit-H3)-DNA were tested. The healthy mouse was injected with PTX intraperitoneally to determine whether PTX intervention could induce NETs formation in vivo. Neutrophils isolated from the peripheral blood of healthy individuals were given different interventions to determine whether PTX and skeletal muscle homogenate can induce neutrophils to form NETs in vitro. EAM-ILD had three pathological phenotypes similar to IIM-ILD. Cit-H3, neutrophil myeloperoxidase, and neutrophil elastase were overexpressed in the lungs of EAM model mice. The serum cfDNA level and Cit-H3-DNA complex level were significantly increased in EAM model mice. Serum cfDNA levels were increased significantly in vivo intervention with PTX in mice. Both PTX and skeletal muscle homogenate-induced neutrophils to form NETs in vitro. EAM-ILD pathological phenotypes are similar to IIM-ILD, and NETs are involved in the development of ILD in a murine model of EAM. Thus, the EAM mouse model can be used as an ideal model targeting NETs to prevent and treat IIM-ILD. A murine model of experimental autoimmune myositis induced by skeletal muscle homogenate and pertussis toxin suffered from interstitial lung disease similar to idiopathic inflammatory myopathy-associated interstitial lung disease. NETs are involved in the occurrence of interstitial lung disease in the model. Graphical Abstract [ABSTRACT FROM AUTHOR]

Published
2024
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89. Additional file 1 of High-efficient production of mushroom polyketide compounds in a platform host Aspergillus oryzae

Author

Han, Haiyan, Yu, Chunyan, Qi, Jianzhao, Wang, Pengchao, Zhao, Peipei, Gong, Wenbing, Xie, Chunliang, Xia, Xuekui, and Liu, Chengwei

Abstract

Additional file 1: Figure S1. NR-PKS and NRPS-like enzyme has been reported to be responsible for the formation of synthetic aldehyde groups. Figure S2. UV spectroscopy of OA. Figure S3. 1H-NMR spectrum of OA (CD3OD-d4, 500 MHz). Figure S4. 13C-NMR spectrum of OA (CD3OD-d4, 125 MHz). Figure S5. 1H-NMR spectrum of o-Orsellinaldehyde (CD3OD-d4, 500 MHz). Figure S6. 13C-NMR spectrum of o-Orsellinaldehyde (CD3OD-d4, 125 MHz). Table S1. Domain organizations of PKS in this study. Table S2. NMR data for OA and o-Orsellinaldehyde in CD3OD-d4 (500 MHz for 1H NMR,125 MHz for 13C NMR). Table S3. DNA and protein sequences. Table S4. Primers used in this study. Table S5. Plasmids constructed in this study.

Published
2023
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90. Dynamic Phasor-Based Stochastic Transient Simulation Method for MTDC Distribution System

Author

Chen, Pengwei, Zhao, Peipei, Lu, Liang, Ruan, Xinbo, and Luo, Chao

Abstract

To investigate the impact of uncertain variability on multiterminal dc distribution systems and provide an efficient simulation tool, this article develops a stochastic transient simulation method based on dynamic phasor (DP). Starting from the lumped elements, the dynamic phasor models of the elements with parameter migration are established first, as well as the corresponding dynamic companion circuits used in digital simulation. By introducing the switching function and low-frequency approximation, the DP-based companion circuit of the voltage source converter is formulated, and the revised nodal voltage equations that can be solved in the framework of Electromagnetic Transients Program are also derived. Then, combined with the discussion on the ill condition of the nodal admittance matrix, the main process of DP-based stochastic transient simulation and the hybrid simulation scheme integrating electromagnetic transient (EMT) simulation are further proposed. Through the comparison with the full EMT simulation and physical experiments, the effectiveness of the DP-based dynamic companion circuits is validated, as well as the efficiency of the proposed simulation method.

Published
2023
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