51. Secondary metabolites isolated from Penicillium christenseniae SD.84 and their antimicrobial resistance effects.
- Author
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Wang, Xinzhu, Meng, Qingzhou, Chen, Haiyan, Yin, Xin, Dai, Huanqin, Zhao, Peipei, Pan, Yang, Xia, Xuekui, and Zhang, Lixin
- Subjects
METABOLITES ,DRUG resistance in microorganisms ,PENICILLIUM ,METHICILLIN-resistant staphylococcus aureus - Abstract
A pair of new quinolone alkaloid enantiomers, (Ra)-(-)-viridicatol (1) and (Sa)-(+)-viridicatol (4), and seven known compounds, namely, 2, 3 and 5–9, were isolated from Penicillium christenseniae SD.84. The structures of 1 and 4 were determined using NMR and HRESIMS data. Theoretical calculations through CD and ECD confirmed 1 and 4 as a pair of enantiomers. The MIC values of 4 against Staphylococcus aureus and methicillin-resistant S. aureus were 12.4 and 24.7 μM, respectively, compound 1 had no inhibitory activity. Antimicrobial assays of 2, 3, and 5–7 showed a moderate activity against S. aureus and methicillin-resistant S. aureus. This study demonstrated the remarkable potential of Penicillium sp. to produce new drug-resistant leading compounds, thereby advancing the mining for new sources of antimicrobial agents. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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