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Generally, the transfer power of wireless power transfer (WPT) system reduces significantly with the increase of distance and angle between transmitting and receiving coils in traditional WPT system. Experiments with two transmitters in the magnetic resonance coupling WPT system have been shown that it can enlarge transfer power and create a stable region in power transfer efficiency in a certain space. However, two transmitters have a limited transfer power comparing to the three-dimensional WPT. In this paper, a model of WPT system with three-dimensional transmitters (3DT-WPT), which are perpendicular to each other and so cover three dimensional spaces, is proposed to overcome the drawbacks mentioned above and the 3DT-WPT system via magnetic resonance coupling is designed to verify the proposed model. The diversity of the characteristics of the transfer power is observed through changing the distance and normal angle between transmitting and receiving coils. Analysis and experiment results show that the proposed method has better performance than the two transmitters. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the effects of long non-coding ribonucleic acid (lncRNA) small nucleolar RNA host gene 1 (SNHG1) on the neuronal apoptosis in rats with cerebral infarction through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. MATERIALS AND METHODS: Male Sprague Dawley (SD) rats were divided into M group (model control group), N group (rat model of cerebral infarction) and R group (rat model of cerebral infarction plus lncRNA SNHG1) and then treated accordingly. 2,3,5-triphenyl tetrazolium chloride (TTC) staining was applied to detect the percentage of cerebral infarct volume and apoptosis of brain cells in the three groups of rats; hematoxylin and eosin (HE) staining was utilized to observe the pathological morphology of brain tissues, and Western blotting was performed to measure the protein levels of phosphorylated PI3K (p-PI3K) and p-Akt in the brain tissues. RESULTS: The degree of neurological deficit in the N group was much higher than that in the M group (p<0.05), and it was decreased markedly in the R group compared with that in the N group, with statistically significant differences (p<0.05). In comparison with that in the M group, the cell apoptosis was aggravated notably in the N group and alleviated remarkably in the R group, and the differences were statistically significant (p<0.05). In the N group, the cerebral infarct volume accounted for 33.67% of the whole brain volume, and mild cerebral infarction was detected in the R group, with a percentage of cerebral infarct volume of 20.15%. N group had a more prominent increase in the cerebral infarct volume than the R group (p<0.05). Compared with those in the M group, the pyknotic nuclei and neuron staining of brain tissues were increased significantly, and the neuronal cell injury was aggravated in the N group, while markedly reduced pyknotic nuclei and neuron staining (p<0.05), as well as mild neuronal cell injury (p<0.05), were detected in the R group. The levels of p-PI3K and p-Akt proteins in the brain tissues declined remarkably in the N group compared with those in the R group (p<0.05). CONCLUSIONS: The protective effect of lncRNA SNHG1 on the rats with cerebral infarction is correlated with the activation of the PI3K/Akt signaling pathway. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the correlations of acute myocardial infarction (AMI) complicated by cerebral infarction with insulin resistance, adiponectin and high-mobility group box 1 (HMGB1). PATIENTS AND METHODS: A total of 326 AMI patients receiving percutaneous coronary intervention (PCI) were selected as the research objects. They were divided into cerebral infarction group (n=24) and non-cerebral infarction group (n=302) based on their complication of cerebral infarction. In addition, 165 healthy people were enrolled as control group. Changes in the levels of HMGB1, adiponectin, fasting insulin (FINS), insulin sensitive index (ISI), insulin resistance, N-terminal pro-B-type natriuretic peptide (NT-proBNP), C-reactive protein (CRP), interleukin- 6 (IL-6), myocardial infarction markers and coagulation function indexes were compared among the three groups. Correlations among those indexes were analyzed. RESULTS: AMI patients had higher levels of HMGB1, FINS, homeostasis model assessment of insulin resistance (HOMA-IR), ISI, creatine kinase isoenzyme (CK-MB), cardiac troponin I (cTnI), prothrombin time (PT), CRP and IL-6 than those in healthy participates, especially in those complicated with cerebral infarction. Conversely, levels of adiponectin, myoglobin (Mb), activated partial thromboplastin time (APTT), antithrombin III (AT-III), activated coagulation time (ACT) and NT-proBNP were the lowest in cerebral infarction group, and highest in control group (p<0.05). AMI complicated with cerebral infarction was negatively correlated with the levels of AT-III and adiponectin, but positively associated with the levels of NT-proBNP, HOMA-IR and HMGB1 (p<0.05). CONCLUSIONS: AMI complicated with cerebral infarction has negative correlations with the levels of AT-III and adiponectin, but positively associated with the levels of NT-proBNP, HOMA- IR and HMGB1, possessing certain clinical significance in AMI treatment. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To explore the role of microRNA-19a-3p in regulating invasion, metastasis and EMT (epithelial mesenchymal transition) of prostate cancer (PCa) cells, as well as its underlying mechanism. MATERIALS AND METHODS: MicroRNA- 19a-3p mimic and negative control plasmid were first constructed. After transfection of microRNA-19a-3p mimic or negative control in DU145 cells, expression levels of microRNA-19a-3p and SOX4 were detected by quantitative Real-time-polymerase chain reaction (qRTPCR) and Western blot. The regulatory effects of microRNA-19a-3p on migration and invasion of DU145 cells were detected by wound healing assay and transwell assay, respectively. Protein levels of matrix metalloproteinase-2 (MMP2), matrix metalloproteinase-9 (MMP9), N-cadherin, Vimentin, alpha-smooth muscle actin (α-SMA) and E-cadherin in DU145 cells transfected with microRNA-19a-3p mimic or negative control were detected by Western blot. RESULTS: Overexpression of microRNA-19a-3p inhibited protein level of SOX4 in DU145 cells. The migration and invasion of DU145 cells were inhibited after transfection of microRNA-19a-3p mimic. Protein levels of MMP2, MMP9, N-cadherin, Vimentin and α-SMA were downregulated, whereas E-cadherin was upregulated after microRNA-19a-3p overexpression. CONCLUSIONS: MicroRNA-19a-3p inhibits migration, invasion and EMT of PCa cells via inhibiting SOX4. [ABSTRACT FROM AUTHOR]