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Multimodal operation is an efficient form of transportation organization. By integrating various modes of transport, the advantages of each mode are fully exerted, and the efficiency and quality of transportation are improved to meet the demand for personalized transport. This article first analyzes the status of multimodal transport development in various regions of Shandong Province; through the analysis of the external environment in which Jinan City is located, it proposes the layout of the Jinan Multimodal Transport Center; finally, it proposes various solutions based on the actual development status.

With the development of economy, efficient organization and transportation are increasingly sought after by people. The comprehensive freight system is the direction of future development. Multimodal transport is a large system composed of a combination of multiple modes of transport. It is a new form of transport organization. In the context of economic globalization, multimodal transport has become one of the most efficient ways to improve efficiency in transportation. This paper uses SWOT analysis to analyze the development of multimodal transportation in Jinan; expounds the internal functional areas of Jinan multimodal transport center; and conducts a detailed analysis of the multimodal transport center planning in Jinan.

Metabolomics have been widely used in pregnancy-related diseases. However, physiological variations induced by chronic hypoxia during pregnancy are not well characterized. We aimed to investigate physiological variations induced by chronic hypoxia during pregnancy. A Sprague–Dawley (SD) pregnant rat model of chronic hypoxia was established. Plasma and urine metabolite profiles at different stages of the pregnancy were detected by 1H NMR (nuclear magnetic resonance). Multivariate statistical analysis was used to analyze changes in plasma and urine metabolic trajectories at different time-points. We identified hypoxia-induced changes in the levels of 30 metabolites in plasma and 29 metabolites in urine during different stages of pregnancy; the prominently affected metabolites included acetic acid, acetone, choline, citric acid, glutamine, isoleucine, lysine, and serine. Most significant hypoxia-induced changes in plasma and urine sample metabolites were observed on the 11th day of gestation. In summary, chronic hypoxia has a significant effect on pregnant rats, and may cause metabolic disorders involving glucose, lipids, amino acids, and tricarboxylic acid cycle. Metabolomics study of the effect of hypoxia during pregnancy may provide insights into the pathogenesis of obstetric disorders. [ABSTRACT FROM AUTHOR]

SUMMARY: Pollen formation and pollen tube growth are essential for the delivery of male gametes into the female embryo sac for double fertilization. Little is known about the mechanisms that regulate the late developmental process of pollen formation and pollen germination. In this study, we characterized a group of Arabidopsis AGC kinase proteins, NDR2/4/5, involved in pollen development and pollen germination. The NDR2/4/5 genes are mainly expressed in pollen grains at the late developmental stages and in pollen tubes. They function redundantly in pollen formation and pollen germination. At the tricellular stages, the ndr2 ndr4 ndr5 mutant pollen grains exhibit an abnormal accumulation of callose, precocious germination and burst in anthers, leading to a drastic reduction in fertilization and a reduced seed set. NDR2/4/5 proteins can interact with another group of proteins (MOB1A/1B) homologous to the MOB proteins from the Hippo signaling pathway in yeast and animals. The Arabidopsis mob1a mob1b mutant pollen grains also have a phenotype similar to that of ndr2 ndr4 ndr5 pollen grains. These results provide new evidence demonstrating that the Hippo signaling components are conserved in plants and play important roles in sexual plant reproduction. Significance Statement: The AGC protein kinases NDR2/4/5 play important roles in the late development of pollen grains and the control of pollen germination through interaction with the MOB1A/1B proteins in Arabidopsis. This study suggests that the core components in the Hippo pathway, NDRs and MOBs, are also functionally conserved in plants. [ABSTRACT FROM AUTHOR]