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A series of poly(ethylene glycol) hexadecyl ether (Brij58)/porous active carbon ( AC) composites were fabricated via a physical method, and their crystallization behavior was characterized in detail using thermogravimetric analysis, X-ray diffraction ( XRD) and differential scanning calorimetry. The Brij58/ AC composites exhibit a good structural-stabilized property, and the decomposition temperature is higher than that of pure components. Obvious crystalline structure and thermal behavior are found when the amount of Brij58 loaded is above 25 wt%. A new peak at 18.9° in XRD patterns proves that the porous AC influences the crystallization and nucleation process of Brij58. From non-isothermal crystallization kinetics, the increased half-time t1/2 and F( T) demonstrate the confined crystallization behavior of Brij58 in AC matrix because of the facile entrapment of hydrophilic poly(ethylene glycol) segments by AC nanopores. Further explanations also arise from the viewpoint of molecular mobility under nanoscale conditions. © 2013 Society of Chemical Industry [ABSTRACT FROM AUTHOR]

Lithium (Li) metal batteries are highly sought after for their exceptional energy density. However, their practical implementation is impeded by the formation of dendrites and significant volume fluctuations in Li, which stem from the uneven distribution of Li-ions and uncontrolled deposition of Li on the current collector. Here, an amino-functionalized reduced graphene oxide covered with polyacrylonitrile (PrGN) film with an electric field gradient structure is prepared to deal with such difficulties. This novel current collector serves to stabilize Li-metal anodes by regulating Li-ion flux through vertically aligned channels formed by porous polyacrylonitrile (PAN). Moreover, the amino-functionalized reduced graphene oxide (rGN) acts as a three-dimensional (3D) host, reducing nucleation overpotential and accommodating volume expansion during cycling. The combination of the insulating PAN and conducting rGN creates an electric field gradient that promotes a bottom-up mode of Li electrodeposition and safeguards the anode from interfacial parasitic reactions. Consequently, the electrodes exhibit exceptional cycle life with stable voltage profiles and minimal hysteresis under high current densities and large areal capacities., (© 2023 Wiley-VCH GmbH.)

Background: Acute-on-chronic liver failure (ACLF) is an acute decompensated syndrome based on chronic liver disease, while neutrophil recruitment is the most critical early step. C-X-C motif chemokine ligand 1 (CXCL1), a cytokine that recruits neutrophils, was significantly upregulated in both ACLF mice and patients with ACLF. This present study aims to explore the role of CXCL1 in the pathogenesis of ACLF., Methods: We established an ACLF mouse model induced by carbon tetrachloride, lipopolysaccharide, and D-galactosamine, and used adeno-associated virus to achieve overexpression and knockdown of Cxcl1. We employed mass cytometry, flow cytometry, multiplex cytokine and chemokine analysis, Western blot, and reactive oxygen species (ROS) detection in mice blood and liver. ACLF patients (n = 10) and healthy controls (n = 5) were included, and their liver samples were stained using multiplex immunohistochemistry techniques., Results: CXCL1 was significantly elevated in both ACLF mice and patients. CXCL1 recruits neutrophils by binding to the C-X-C motif chemokine receptor 2 on the surface of neutrophils, affects ACLF prognosis by generating ROS and mitochondrial depolarization and modulating caspase3-related apoptotic pathways. We found that the knockdown of CXCL1 attenuated the infiltration of neutrophils in the mouse liver, reduced the expression of inflammatory cytokines, and also significantly downregulated ROS production and caspase3-related hepatocyte apoptosis, thereby ameliorating the liver injury of ACLF., Conclusions: CXCL1 is a core player in the mobilization of neutrophils in ACLF, and the knockdown of Cxcl1 improves neutrophil infiltration, reduces ROS levels, and reduces hepatocyte apoptosis, thereby attenuating inflammation and liver injury in ACLF. Our results revealed a previously unknown link between CXCL1-induced neutrophil recruitment and ACLF, providing evidencing for potential therapies targeting ACLF., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.)

Rational design of nanosystems that target tumor microenvironment have attracted widespread attention. However, it is still a great challenge to make a multifunctional nanoplatform that actively and selectively interacts with tumor microenvironment, without causing toxicity to surrounding normal tissues. Herein, the biodegradable Fe-doped MoO x (FMO) nanowires are designed as an anti-tumor nanoreagent that possesses great photothermal conversion ability (48.5%) and magnetic properties for T1 weighted magnetic resonance imaging (MRI). Also, FMO can be used as a chemodynamic therapy (CDT) reagent to effectively catalyze the decomposition of H 2 O 2 and produce hydroxyl radical (·OH). At the same time, the consumption of glutathione will also enhance the CDT effect. More importantly, FMO presents pH-dependent degradation behavior: rapid degradation at physiological pH, but relatively stable at acidic pH. In vivo anti-tumor experiment demonstrates that the FMO is able to effectively inhibit the tumor growth with minimal side effects. Generally speaking, these results indicate that the FMO has huge potential for MRI image-guided cancer therapy and promotes the clinical translation of nanodrugs., (© 2020 Wiley-VCH GmbH.)