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258 results on '"Zhang, Guijuan"'

60. Prospects of Immunotherapy for Triple-Negative Breast Cancer

Author

Qiu, Dan, primary, Zhang, Guijuan, additional, Yan, Xianxin, additional, Xiao, Xinqin, additional, Ma, Xinyi, additional, Lin, Shujun, additional, Wu, Jieyan, additional, Li, Xinyuan, additional, Wang, Wandi, additional, Liu, Junchen, additional, Ma, Yi, additional, and Ma, Min, additional

Published
2022
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71. Depression and Related Factors in Patients with Parkinson’s Disease at High Altitude

Author

Cao,Yu, Li,Gongfeng, Xue,Jinsheng, Zhang,Guijuan, Gao,Sensen, Huang,Yuling, Zhu,Aiqin, Cao,Yu, Li,Gongfeng, Xue,Jinsheng, Zhang,Guijuan, Gao,Sensen, Huang,Yuling, and Zhu,Aiqin

Abstract

Yu Cao,1,* Gongfeng Li,1,* Jinsheng Xue,2,* Guijuan Zhang,1 Sensen Gao,1 Yuling Huang,1 Aiqin Zhu1 1Institute of Geriatric, Qinghai Provincial People’s Hospital, Xining, People’s Republic of China; 2Foreign Cooperation Office, Chengdu Fifth People’s Hospital, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Aiqin ZhuInstitute of Geriatric, Qinghai Provincial People’s Hospital, No. 2 Gonghe Road, Xining, Qinghai, 810007, People’s Republic of ChinaTel +8613139069938Fax +869718176273Email zhuaq@hotmail.comPurpose: Depression seems to aggravate progression of Parkinson’s disease (PD). Hypoxia stress may be one of the pathogenic factors leading to PD. We investigated the characteristics of PD and factors related to Parkinson’s disease depression (PDD) at high altitude (mean altitude ≥ 2300 m).Patients and Methods: Totally 221 PD patients of three different nationalities (Han, Hui, and Tibetan) were recruited in a high-altitude hospital. Depression was present in 55.6% of them. Patient data were examined, including demographic information, medical history, disease duration and family history. Psychopathological characteristics and motor signs were assessed by the Hamilton Depression scale (HAMD) and scales for motor and non-motor symptoms in the Unified Parkinson’s Disease Rating Scale (UPDRS). Progression of PD was evaluated by the modified Hoehn and Yahr (H-Y) staging system.Results: Mean age (47.1% men) was 68.25± 13.67 years old, with disease duration of 4.18± 5.13 years and median H-Y scores 2.07± 0.97 points. Among three different nationalities, PD rate was 69.2% in Han nationals, 17.6% in Hui nationals and 13.1% in Tibetans of 221 PD patients. Compared with the non-depressed PD group, female, no-smoking and living alone rates, and dysphagia, pain, H-Y stage, ADL, UPDRS-I, UPDRS-III, HAMA

Published
2021

73. Acetyl-11-keto-β-boswellic Acid Inhibits Precancerous Breast Lesion MCF-10AT Cells via Regulation of LINC00707/miR-206 that Reduces Estrogen Receptor-α

Author

Jiang,Xuefeng, Liu,Yusheng, Zhang,Guijuan, Lin,Shujun, Yuan,Naijun, Wu,Jieyan, Yan,Xianxin, Ma,Yi, and Ma,Min

Subjects
Cancer Management and Research
Abstract

Xuefeng Jiang,1,* Yusheng Liu,1,* Guijuan Zhang,2,* Shujun Lin,1 Naijun Yuan,1 Jieyan Wu,1 Xianxin Yan,1 Yi Ma,3 Min Ma1,2 1College of Traditional Chinese Medicine of Jinan University, Guangzhou, People’s Republic of China; 2The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China; 3Institute of Biomedicine and Department of Cellular Biology, Jinan University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Min MaCollege of Traditional Chinese Medicine of Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, People’s Republic of ChinaTel +86 15876583624Fax +86 20-85227173Email 2246809300@qq.comPurpose: Acetyl-11-keto-β-boswellic acid (AKBA) has therapeutic effects on a range of diseases, including tumours. lncRNAs, as competing endogenous RNAs (ceRNAs), can interact with miRNAs to regulate the expression of target genes, which can affect the development of tumors. Here, we examined the effects of AKBA on breast precancerous lesions MCF-10AT cells.Methods: The expression profiles of breast cancer (BC) tissue were collated from The Cancer Genome Atlas (TCGA), and the lncRNA-miRNA-mRNA ceRNA network was constructed. AKBA targets were predicted by network pharmacology. The expression of long intergenic nonprotein-coding RNA 707 (LINC00707), miR-206 and ER-α was determined by qRT-PCR. Cell viability, apoptosis and cycle were assessed by CCK-8 and flow cytometry. Protein levels were measured by Western blotting.Results: A total of 3205 differentially expressed mRNAs, 104 miRNAs, and 605 lncRNAs were identified. The ceRNA network consisting of 9 lncRNAs, 15 miRNAs and 82 mRNAs was constructed. We found that LINC00707 was up-regulated and miR-206 was down-regulated in MCF-10AT cells. Transfected si-LINC00707 could inhibit cell proliferation, induce cell apoptosis and cycle arrest of MCF-10AT cells. In addition, network pharmacology predicted that AKBA may regulate the ESR1 in the treatment of BC. Our research demonstrated that AKBA could induce cell apoptosis and G1-phase arrest and inhibit ER-α expression via LINC00707/miR-206 in MCF-10AT cells.Conclusion: AKBA inhibited MCF-10AT cells via regulation of LINC00707/miR-206 that reduces ER-α.Keywords: breast precancerous lesion, acetyl-11-keto-β-boswellic acid, ceRNA, LINC00707, miR-206, ESR1

Published
2020

84. Research on Segmentation Method of Train Braking Curve Based on Particle Swarm Optimization.

Author

Bao Pengyu, Chen Zhiqiang, Wang Jianmin, Yu Xiaona, Zhang Youbing, and Zhang Guijuan

Abstract

As When the braking deceleration performance curve of trains need to be processed in a segmentation and approximation way, the braking curves of diff erent types of trains are quite diff erent, there is no unifi ed braking curve segmentation scheme. This paper proposes a method of train braking curve segmentation based on particle swarm optimization. This method takes the braking segment point as the optimization parameter and the braking distance as the optimization target, which can realize the optimal approximation of any segment of the train braking curve. Since this method has nothing to do with the type of train, the shape of the braking curve, and the number of segments, it can be applied to the braking curve segmentation of all kinds of trains and has good application value. [ABSTRACT FROM AUTHOR]

Published
2021
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