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569 results on '"Zhai, Zhen"'

66. Global Burden of Female Breast Cancer: Age-Period-Cohort Analysis of Incidence Trends From 1990 to 2019 and Forecasts for 2035

Author

Li, Yizhen, primary, Zheng, Jinxin, additional, Deng, Yujiao, additional, Deng, Xinyue, additional, Lou, Weiyang, additional, Wei, Bajin, additional, Xiang, Dong, additional, Hu, Jingjing, additional, Zheng, Yi, additional, Xu, Peng, additional, Yao, Jia, additional, Zhai, Zhen, additional, Zhou, Linghui, additional, Yang, Si, additional, Wu, Ying, additional, Kang, Huafeng, additional, and Dai, Zhijun, additional

Published
2022
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67. Fast tree based nearest neighbor search

Author

Zhai, Zhen

Subjects
Computer science, Algorithm, Machine Learning, Nearest Neighbor Search
Abstract

Nearest neighbor search is a basic primitive method used for machine learning and information retrieval. We look at exact nearest neighbor search algorithms using tree structures. The most basic tree structure used for fast nearest neighbor search is k-d trees. This thesis will look at k-d tree’s shortcomings and explore various ways to improve its performance. First, we look at PCA trees, which give good performance but is time-expensive. We then study randomized trees, which are very efficient data structures and are flexible in space complexity. Then we introduce a new randomized tree structure, two-vantage-point tree, which outperforms all other tree structures including PCA trees, r-k-d trees, and RP trees. At last, we look at spillover on trees, which can be used to improve the performance of any tree structures. We then compare randomized trees with spillover and show that spill trees only work well with very small spill factor. If more space is allowed, two-vantage-point trees are preferred over spill trees.

Published
2017

70. Promoting effect of Nano-Se on tobacco growth and reactive oxygen species metabolism

Author

Taibo Liang, Meng Xiangyu, Juan Liu, Huaxin Dai, Zhai Zhen, Álvaro Sanz-Sáez, and Yang Liu

Subjects
0106 biological sciences, Reactive oxygen species metabolism, Physiology, Chemistry, fungi, technology, industry, and agriculture, food and beverages, 04 agricultural and veterinary sciences, 01 natural sciences, Environmental chemistry, Nano, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Agronomy and Crop Science, 010606 plant biology & botany
Abstract

Se is beneficial to plants’ growth and it is an essential mineral for animals and humans. However, relatively little is known about the relationship between nano-Se concentrations and plant antioxi...

Published
2020

73. Variations in Sources, Composition, and Exposure Risks of PM2.5 in both Pre-Heating and Heating Seasons

Author

Yang, Dingyuan, primary, Li, Zhiyong, additional, Yue, Ziyuan, additional, Liu, Jixiang, additional, Zhai, Zhen, additional, Li, Zelin, additional, Gao, Minglei, additional, Hu, Ailian, additional, Zhu, Wenjia, additional, Ding, Ning, additional, Li, Zhenxin, additional, Guo, Songtao, additional, Wang, Xiangxue, additional, Wang, Lei, additional, and Wei, Jihong, additional

Published
2022
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79. Impact of Preoperative vs Postoperative Radiotherapy on Overall Survival of Locally Advanced Breast Cancer Patients

Author

Deng, Yujiao, primary, Li, Hongtao, additional, Zheng, Yi, additional, Zhai, Zhen, additional, Wang, Meng, additional, Lin, Shuai, additional, Li, Yizhen, additional, Wei, Bajin, additional, Xu, Peng, additional, Wu, Ying, additional, Deng, Xinyue, additional, Yang, Si, additional, Lyu, Jun, additional, Hu, Jingjing, additional, Dong, Huaying, additional, and Dai, Zhijun, additional

Published
2021
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80. Global Burden of Respiratory Diseases Attributable to Ambient Particulate Matter Pollution: Findings From the Global Burden of Disease Study 2019

Author

Wu, Ying, primary, Song, Ping, additional, Lin, Shuai, additional, Peng, Ling, additional, Li, Yizhen, additional, Deng, Yujiao, additional, Deng, Xinyue, additional, Lou, Weiyang, additional, Yang, Si, additional, Zheng, Yi, additional, Xiang, Dong, additional, Hu, Jingjing, additional, Zhu, Yuyao, additional, Wang, Meng, additional, Zhai, Zhen, additional, Zhang, Dai, additional, Dai, Zhijun, additional, and Gao, Jie, additional

Published
2021
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81. Global Burden of Female Breast Cancer: Age-period-cohort Analysis of Incidence Trends from 1990 to 2019 and Forecasts for 2035

Author

Li, Yizhen, primary, Zheng, Jinxin, additional, Deng, Yujiao, additional, Deng, Xinyue, additional, Lou, Weiyang, additional, Wei, Bajin, additional, Xiang, Dong, additional, Hu, Jingjing, additional, Zheng, Yi, additional, Xu, Peng, additional, Yao, Jia, additional, Zhai, Zhen, additional, Zhou, Linghui, additional, Yang, Si, additional, Wu, Ying, additional, Kang, Huafeng, additional, and Dai, Zhi-Jun, additional

Published
2021
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84. Association Between Genetic Polymorphisms In TYMS And Glioma Risk In Chinese Patients: A Case-Control Study

Author

Yao, Li, Zhou, Linghui, Deng, Yujiao, Zheng, Yi, Yang, Pengtao, Wang, Meng, Dong, Shanshan, Hao, Qian, Xu, Peng, Li, Na, Wu, Ying, Zhai, Zhen, Lyu, Lijuan, and Dai, Zhijun

Subjects
gene variant, glioma, case-control study, TYMS, OncoTargets and Therapy, susceptibility, Original Research
Abstract

Li Yao,1,* Linghui Zhou,2,3,* Yujiao Deng,2,3,* Yi Zheng,2,3 Pengtao Yang,2 Meng Wang,2 Shanshan Dong,4 Qian Hao,2,3 Peng Xu,2,3 Na Li,2,3 Ying Wu,2,3 Zhen Zhai,2,3 Lijuan Lyu,2,3 Zhijun Dai2,3 1Department of Neurology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, People’s Republic of China; 2Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, People’s Republic of China; 3Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of China; 4School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhijun DaiDepartment of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, People’s Republic of ChinaEmail dzj0911@126.comBackground: Thymidylate synthase (TYMS) polymorphisms are reported to be related to susceptibility to some cancers. However, no study exists on TYMS polymorphisms and glioma risk. This study aimed to evaluate the relationship between two common TYMS gene variants (rs1059394 C>T, rs2847153 G>A) and glioma susceptibility.Methods: This case-control study included 605 patients and 1300 cancer-free individuals. Genotyping was performed using Sequenom Mass-ARRAY. We determined odds ratios (ORs) and their 95% confidence intervals (CIs) to estimate the correlations.Results: The analysis revealed that rs1059394 TT and CT+TT genotype had significantly low glioma risk (TT to CC: OR = 0.71, 95% CI = 0.52–0.97, P = 0.03; CT+TT to CC: OR = 0.74, 95% CI = 0.55–0.99, P = 0.04). However, no significant difference was found between rs2847153 and glioma risk in any genetic model (Pï¹¥0.05). In high-grade gliomas, the GA and GA+AA genotypes of rs2847153 made the majority of genotypes, compared with GG genotype (GA to GG: OR = 2.01, 95% CI = 1.39–2.91, P < 0.001; GA+AA to GG: OR = 1.78, 95% CI =1.25–2.54, P < 0.001). Moreover, online expression quantitative trait locus (eQTL) analysis indicated that these two polymorphisms may alter TYMS gene expression in transformed fibroblast cells.Conclusion: Our study provides evidence of the effect of TYMS rs1059394 on the susceptibility of glioma. In high-grade gliomas, compared with GG genotype, the GA and GA+AA genotypes of rs2847153 comprise a larger proportion.Keywords: TYMS, glioma, gene variant, susceptibility, case-control study

Published
2019

85. Tracheal, bronchus, and lung cancer burden and related risk factors in the United States and China

Author

Deng, Yujiao, Peng, Ling, Li, Na, Zhai, Zhen, Xiang, Dong, Ye, Xianghua, Hu, Jingjing, Zheng, Yi, Yao, Jia, Wang, Shuqian, Wei, Bajin, Xu, Peng, Zhang, Dai, Tianhui Chen, and Dai, Zhijun

Subjects
Original Article
Abstract

Tracheal, bronchus, and lung (TBL) cancer is the most common malignant tumor worldwide. This study aims to grasp the characteristics of the TBL cancer burden in China and the United States (USA). Data included incidence, deaths, and disability-adjusted life years (DALYs) as well as their age-standardized rates (ASRs) among different gender, age and risk factors. Joinpoint Regression Model and Age-period-cohort (APC) analysis were used to evaluate the variation tendency and effect of the risk factors. China and USA bore almost half of the TBL cancer burden, especially for males. ASRs of TBL cancer increased in China, but decreased in USA. In China, three factors related to TBL cancer deaths and DALYs related were tobacco, air pollution, and diet low in fruits; in USA, these are tobacco, occupational carcinogens, and high fasting plasma glucose. The younger the population, the less impact of birth cohort on morbidity and mortality. According to APC analysis, age effect played a key role in morbidity and mortality of TBL cancer, and the risk increased with age. Period effect kept increasing over time, while cohort effect decreased with the time of birth. Tobacco was always the top risk factor of death and DALYs in both countries. The policy should be tilted towards air pollution and a diet low in fruits in China, as well as occupational carcinogens and high fasting plasma glucose in USA. Healthcare reform in both countries should focus on planning how its health system could effectively prevent and manage TBL cancer at low cost.

Published
2021

87. Dietary Risk-Related Colorectal Cancer Burden: Estimates From 1990 to 2019

Author

Deng, Yujiao, primary, Wei, Bajin, additional, Zhai, Zhen, additional, Zheng, Yi, additional, Yao, Jia, additional, Wang, Shuqian, additional, Xiang, Dong, additional, Hu, Jingjing, additional, Ye, Xianghua, additional, Yang, Si, additional, Wu, Ying, additional, Li, Na, additional, Xu, Peng, additional, Lyu, Jun, additional, and Dai, Zhijun, additional

Published
2021
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88. Estimates of Type 2 Diabetes Mellitus Burden Attributable to Particulate Matter Pollution and Its 30-Year Change Patterns: A Systematic Analysis of Data From the Global Burden of Disease Study 2019

Author

Wu, Ying, primary, Fu, Rongguo, additional, Lei, Chen, additional, Deng, Yujiao, additional, Lou, Weiyang, additional, Wang, Li, additional, Zheng, Yi, additional, Deng, Xinyue, additional, Yang, Si, additional, Wang, Meng, additional, Zhai, Zhen, additional, Zhu, Yuyao, additional, Xiang, Dong, additional, Hu, Jingjing, additional, Dai, Zhijun, additional, and Gao, Jie, additional

Published
2021
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89. Assessment of Global Trends in the Diagnosis of Mesothelioma From 1990 to 2017

Author

Zhai, Zhen, primary, Ruan, Jian, additional, Zheng, Yi, additional, Xiang, Dong, additional, Li, Na, additional, Hu, Jingjing, additional, Shen, Jianfei, additional, Deng, Yujiao, additional, Yao, Jia, additional, Zhao, Peng, additional, Wang, Shuqian, additional, Yang, Si, additional, Zhou, Linghui, additional, Wu, Ying, additional, Xu, Peng, additional, Lyu, Lijuan, additional, Lyu, Jun, additional, Bergan, Raymond, additional, Chen, Tianhui, additional, and Dai, Zhijun, additional

Published
2021
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90. Burden of Liver Cancer Attributable to Five Risk Factors by Specific Etiologies in 204 Countries and Territories

Author

Li, Yizhen, primary, Wei, Bajin, additional, Deng, Yujiao, additional, Liu, Yuanxing, additional, Deng, Xinyue, additional, Xiang, Dong, additional, Hu, Jingjing, additional, Zheng, Yi, additional, Xu, Peng, additional, Yao, Jia, additional, Zhai, Zhen, additional, Zhou, Linghui, additional, Yang, Si, additional, Wu, Ying, additional, Zheng, Shusen, additional, and Dai, Zhijun, additional

Published
2021
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94. A Feasibility Study on Using Single-Photon Emission Computed Tomography Pulmonary Perfusion/Ventilation Imaging for the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension and Patient Risk Assessment

Author

Ma,Rong-Zheng, Han,Ping-Ping, Tao,Xin-Cao, Li,Huan, Wang,Ling, Zhai,Zhen-Guo, Fu,Li-Ping, Ma,Rong-Zheng, Han,Ping-Ping, Tao,Xin-Cao, Li,Huan, Wang,Ling, Zhai,Zhen-Guo, and Fu,Li-Ping

Abstract

Rong-Zheng Ma,1 Ping-Ping Han,1 Xin-Cao Tao,2 Huan Li,1 Ling Wang,1 Zhen-Guo Zhai,2 Li-Ping Fu1 1Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Diseases, Beijing, 100029, People’s Republic of ChinaCorrespondence: Li-Ping FuDepartment of Nuclear Medicine, China-Japan Friendship Hospital, No. 2 of Yinghuayuan Road, Chaoyang District, Beijing, 100029, People’s Republic of ChinaTel +86 10 84205389Fax +86 10-84205389Email fulipjh@126.comZhen-Guo ZhaiDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, No. 2 of Yinghuayuan Road, Chaoyang District, Beijing, 100029, People’s Republic of ChinaTel +86 10 84206269Fax +86 10 84206269Email zhaizhguo235@outlook.comObjective: The study is designed to evaluate the diagnostic ability of single-photon emission computed tomography (SPECT) pulmonary ventilation/perfusion (V/Q) imaging in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and investigate its feasibility in assessing patient risk.Methods: A total of 83 patients suspected of having CTEPH who received V/Q tomography were retrospectively analyzed. The consistency between SPECT V/Q imaging and pulmonary angiography was compared to investigate the correlation between the percentage of pulmonary perfusion defect score (PPDs%) and the hemodynamic indices. Patients were grouped according to the pulmonary arterial hypertension risk stratification, and the V/Q imaging results were compared between different groups.Results: For the 1494 pulmonary segments of the 83 patients, the sensitivity, specificity, and accuracy of identifying pulmonary segments with defects using V/Q imaging was 87.05%, 82.78% (668/807), and 84.7

Published
2021

99. Identification of an immune-related RNA-binding protein signature to predict survival and targeted therapy responses in liver cancer

Author

Yang, Si, primary, Lin, Shuai, additional, Liu, Kang, additional, Liu, Yuanxing, additional, Xu, Peng, additional, Zheng, Yi, additional, Deng, Yujiao, additional, Zhang, Dai, additional, Zhai, Zhen, additional, Li, Na, additional, Ren, Xueting, additional, Dai, Zhijun, additional, and Kang, Huafeng, additional

Published
2021
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100. Therapeutic Effect of Doxorubicin-Chlorin E6-Loaded Mesoporous Silica Nanoparticles Combined with Ultrasound on Triple-Negative Breast Cancer

Author

Xu,Peng, Yao,Jia, Li,Zhen, Wang,Meng, Zhou,Linghui, Zhong,Guansheng, Zheng,Yi, Li,Na, Zhai,Zhen, Yang,Si, Wu,Ying, Zhang,Dai, and Dai,Zhijun

Subjects
International Journal of Nanomedicine
Abstract

Peng Xu,1,2,* Jia Yao,1,* Zhen Li,3,* Meng Wang,2 Linghui Zhou,1,2 Guansheng Zhong,1 Yi Zheng,1,2 Na Li,1,2 Zhen Zhai,1,2 Si Yang,1,2 Ying Wu,1,2 Dai Zhang,2 Zhijun Dai1 1Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of China; 2Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, People’s Republic of China; 3Department of Student Affairs, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhijun DaiDepartment of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of ChinaTel +86 571 8723 6852Email dzj0911@126.comIntroduction: Sonodynamic Therapy (SDT) has good targeting and non-invasive advantages in solid cancers, but its antitumor effect is not sufficient to replace traditional treatments. Some studies that combined SDT with chemotherapy or nanoparticles have managed to enhance its efficiency and overcome the side effects of chemotherapy.MaterialsandMethods: In this study, we synthesized and characterized mesoporous silica nanoparticles (MSN-DOX-Ce6) loaded with doxorubicin (DOX) and sonosensitizer, chlorin e6 (Ce6). Then, we conducted in vitro and in vivo experiments to explore the antitumor effect of MSN-DOX-Ce6 under ultrasound(US) treatment.Results: The characterization tests showed that the nanoparticles are uniformly sized spheres with mesoporous structure, resulting in a high drug-loading efficiency. In the in vitro experiments, MSN-DOX-Ce6 could effectively inhibit cell proliferation under US but not more than other treatment groups. However, the in vivo studies showed that MSN-DOX-Ce6+US has better antitumor effect than DOX+Ce6+US or DOX alone on xenograft tumor-bearing mice.Conclusion: In summary, MSNs showed a great potential for DOX and Ce6 delivery. We concluded that under US, MSN-DOX-Ce6 nanocomposites increase the antitumor effect of DOX and SDT and thereby are a potential treatment for solid tumors.Keywords: sonodynamic therapy, co-delivery, combination chemotherapy, nanomaterials

Published
2020

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