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51. Is APOE ε4 associated with cognitive performance in early MS?

Author

Engel, Sinah, Graetz, Christiane, Salmen, Anke, Muthuraman, Muthuraman, Toenges, Gerrit, Ambrosius, Björn, Bayas, Antonios, Berthele, Achim, Heesen, Christoph, Klotz, Luisa, Kümpfel, Tania, Linker, Ralf A., Meuth, Sven G., Paul, Friedemann, Stangel, Martin, Tackenberg, Björn, Then Bergh, Florian, Tumani, Hayrettin, Weber, Frank, Wildemann, Brigitte, Zettl, Uwe K., Antony, Gisela, Bittner, Stefan, Groppa, Sergiu, Hemmer, Bernhard, Wiendl, Heinz, Gold, Ralf, Zipp, Frauke, Lill, Christina M., and Luessi, Felix

Published
2020
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55. TPP2 mutation associated with sterile brain inflammation mimicking MS

Author

Reinthaler, Eva M., Graf, Elisabeth, Zrzavy, Tobias, Wieland, Thomas, Hotzy, Christoph, Kopecky, Chantal, Pferschy, Sandra, Schmied, Christiane, Leutmezer, Fritz, Keilani, Mohammad, Lill, Christina M., Hoffjan, Sabine, Epplen, Jörg T., Zettl, Uwe K., Hecker, Michael, Deutschländer, Angela, Meuth, Sven G., Ahram, Mamoun, Mustafa, Baha, El-Khateeb, Mohammed, Vilariño-Güell, Carles, Sadovnick, A. Dessa, Zimprich, Fritz, Tomkinson, Birgitta, Strom, Tim, Kristoferitsch, Wolfgang, Lassmann, Hans, and Zimprich, Alexander

Published
2018
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56. Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions

Author

Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Krumbholz, Markus, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Zettl, Uwe K., Faiss, Jürgen, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, Trebst, Corinna, Albrecht, P., Ayzenberg, I., Bayas, A., Bellmann-Strobl, J., Bischof, F., Bittner, S., Böttcher, T., Brettschneider, J., Buttmann, M., DSouza, M., Ettrich, B., Frank, B., Gass, A., Grothe, M., Guthke, K., Haarmann, A., Habedank, E., Hoffmann, F., Hoffmann, O., Hümmert, M.W., Junghans, J., Kaste, M., Kaulen, B., Kermer, P., Kern, P., Klotz, L., Köhler, W., Kolesilova, E., Korsen, M., Kowarik, M., Langel, S., Lee, D.H., Liebetrau, M., Luessi, F., Marouf, W., Meister, S., Melms, A., Metz, I., Münch, C., Niehaus, S., Pawlitzki, M., Pellkofer, H., Puhlmann, H.U., Pul, R., Retzlaf, N., Riedlinger, A., Rommer, P., Röpke, L., Rostásy, K., Rückriem, L., Ruschil, C., Schippling, S., Senel, M., Sieb, J.P., Sommer, C., Spreer, A., Steinbrecher, A., Stephanik, H., Stoppe, M., Süße, M., Tackenberg, B., Tünnerhoff, J., Veauthier, C., Walter, A., Wandinger, K.P., Warnke, C., Weber, M.S., Weissert, R., Wiendl, H., Wilke, C., Winkelmann, A., Yalachkov, Y., Young, K., Zentner, C., and Zipp, F.

Published
2018
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60. Autorenverzeichnis

Author

Aktas, Orhan, primary, Alvermann, Sascha, additional, Block, Anja, additional, Brück, Wolfgang, additional, Faiss, Jürgen, additional, Fitzner, Brit, additional, Flachenecker, Peter, additional, Gärtner, Jutta, additional, Gerken, Jeanine, additional, Haas, Judith, additional, Hardt, Cornelia, additional, Haupts, Michael, additional, Hecker, Michael, additional, Hoffmann, Frank A., additional, Hoppenworth, Uwe, additional, Huppke, Peter, additional, Kern, Raimar, additional, Köhler, Wolfgang, additional, Krumbholz, Markus, additional, Kunkel, Annett, additional, Linke, Ernst, additional, Martin, Roland, additional, Meinl, Edgar, additional, Pöhlau, Dieter, additional, Reinshagen, Alexander, additional, Rieckmann, Peter, additional, Sailer, Michael, additional, Schifferdecker, Michael, additional, Schipper, Sabine, additional, Schippling, Sven, additional, Schmidt, Rudolf, additional, Schmitt, Hendrik, additional, Sokol, Christina, additional, Stadelmann-Nessler, Christine, additional, Stangel, Martin, additional, Tumani, Hayrettin, additional, Zettl, Uwe K., additional, Ziemssen, Tjalf, additional, Zimmermann, Klaus, additional, Zipp, Frauke, additional, and Littig, Eva, additional

Published
2018
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61. Nachruf statt Vorwort

Author

Schmidt, Rudolf Manfred, primary, Hoffmann, Frank A., additional, Faiss, Jürgen H., additional, Köhler, Wolfgang, additional, and Zettl, Uwe K., additional

Published
2018
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62. Occurrence and Risk Factors of Relapse Activity after Vaccination against COVID-19 in People with Multiple Sclerosis: 1-Year Follow-Up Results from a Nationwide Longitudinal Observational Study.

Author

Fneish, Firas, Frahm, Niklas, Peters, Melanie, Ellenberger, David, Haas, Judith, Löbermann, Micha, Pöhlau, Dieter, Röper, Anna-Lena, Schilling, Sarah, Stahmann, Alexander, Temmes, Herbert, Paul, Friedemann, and Zettl, Uwe K.

Subjects
MULTIPLE sclerosis, BOOSTER vaccines, COVID-19 vaccines, LONGITUDINAL method, SCIENTIFIC observation, AUTOIMMUNE diseases
Abstract

Several studies reported post-SARS-CoV-2-vaccination (PV) symptoms. Even people with multiple sclerosis (PwMS) have concerns about disease activity following the SARS-CoV-2 vaccination. We aimed to determine the proportion of PwMS with PV relapses, the PV annualized relapse rate (ARR), the time from vaccination to subsequent relapses, and identify sociodemographic/clinical risk factors for PV relapses. PwMS were surveyed several times at baseline and four follow-ups as part of a longitudinal observational study regarding the safety and tolerability of the SARS-CoV-2 vaccination. The inclusion criteria for this analysis were age ≥18 years, ≥1 SARS-CoV-2 vaccination, and ≥1-year observation period since initial vaccination. Of 2466 PwMS, 13.8% reported PV relapses (mostly after second [N = 147] or booster vaccination [N = 145]) at a median of 8.0 (first/third quantile: 3.55/18.1) weeks PV, with the shortest period following initial vaccination (3.95 weeks). The ARR was 0.153 (95% confidence interval: 0.138–0.168), with a median observation period since initial vaccination of 1.2 years. Risk factors for PV relapses were younger age, female gender, moderate-severe disability levels, concurrent autoimmune diseases, relapsing-remitting MS courses, no DMT, and relapses within the year prior to the first vaccination. Patients' health conditions before/during initial vaccination may play a more important role in PV relapse occurrence than vaccination per se. [ABSTRACT FROM AUTHOR]

Published
2023
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63. Epileptic seizures at multiple sclerosis onset and their role in disease progression.

Author

Grothe, Matthias, Ellenberger, David, Rommer, Paulus S., Stahmann, Alexander, and Zettl, Uwe K.

Subjects
MULTIPLE sclerosis, EPILEPSY, DISEASE progression, PATHOLOGICAL physiology, SEIZURES (Medicine)
Abstract

Background: Epileptic seizures can occur throughout the course of multiple sclerosis (MS) and are associated with increasing disability progression over time. However, there are no data on whether epileptic seizures at the onset of MS also lead to increasing disability. Objective: To examine disease progression over time for MS patients with epileptic seizures at onset. Methods: We analyzed the data of 30,713 patients on the German Multiple Sclerosis Register in a case–control study for more than 15 years. MS patients with seizures at onset were further divided into subgroups with polysymptomatic and monosymptomatic onset to assess the impact of additional symptoms on disease progression. Results: A total of 46 patients had seizures as onset symptoms. Expanded Disability Status Scale (EDSS) within the first year was lower in the group with seizures at onset compared to controls (0.75 versus 1.6, p < 0.05), which changed until the last reported visit (3.11 versus 3.0). Both subgroups revealed increased EDSS progression over time compared to controls. Conclusion: Epileptic seizures at MS onset are associated with a higher amount of disability progression over time. Additional longitudinal data are needed to further clarify the impact of seizures on the pathophysiology of MS disease progression. [ABSTRACT FROM AUTHOR]

Published
2023
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66. Association of obesity with disease outcome in multiple sclerosis

Author

Lutfullin, Isabel, primary, Eveslage, Maria, additional, Bittner, Stefan, additional, Antony, Gisela, additional, Flaskamp, Martina, additional, Luessi, Felix, additional, Salmen, Anke, additional, Gisevius, Barbara, additional, Klotz, Luisa, additional, Korsukewitz, Catharina, additional, Berthele, Achim, additional, Groppa, Sergiu, additional, Then Bergh, Florian, additional, Wildemann, Brigitte, additional, Bayas, Antonios, additional, Tumani, Hayrettin, additional, Meuth, Sven G, additional, Trebst, Corinna, additional, Zettl, Uwe K, additional, Paul, Friedemann, additional, Heesen, Christoph, additional, Kuempfel, Tania, additional, Gold, Ralf, additional, Hemmer, Bernhard, additional, Zipp, Frauke, additional, Wiendl, Heinz, additional, and Lünemann, Jan D, additional

Published
2022
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74. Importance of cerebrospinal fluid analysis in the era of McDonald 2010 criteria: a German–Austrian retrospective multicenter study in patients with a clinically isolated syndrome

Author

Huss, André M., Halbgebauer, Steffen, Öckl, Patrick, Trebst, Corinna, Spreer, Annette, Borisow, Nadja, Harrer, Andrea, Brecht, Isabel, Balint, Bettina, Stich, Oliver, Schlegel, Sabine, Retzlaff, Nele, Winkelmann, Alexander, Roesler, Romy, Lauda, Florian, Yildiz, Özlem, Voß, Elke, Muche, Rainer, Rauer, Sebastian, Bergh, Florian Then, Otto, Markus, Paul, Friedemann, Wildemann, Brigitte, Kraus, Jörg, Ruprecht, Klemens, Stangel, Martin, Buttmann, Mathias, Zettl, Uwe K., and Tumani, Hayrettin

Published
2016
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77. Association of obesity with disease outcome in multiple sclerosis

Author

Lutfullin, Isabel, Eveslage, Maria, Bittner, Stefan, Antony, Gisela, Flaskamp, Martina, Luessi, Felix, Salmen, Anke, Gisevius, Barbara, Klotz, Luisa, Korsukewitz, Catharina, Berthele, Achim, Groppa, Sergiu, Then Bergh, Florian, Wildemann, Brigitte, Bayas, Antonois, Tumani, Hayrettin, Meuth, Sven G., Trebst, Corinna, Zettl, Uwe K., Paul, Friedemann, Heesen, Christoph, Kuempfel, Tania, Gold, Ralf, Hemmer, Bernhard, Zipp, Frauke, Wiendl, Heinz, Lünemann, Jan D., Lutfullin, Isabel, Eveslage, Maria, Bittner, Stefan, Antony, Gisela, Flaskamp, Martina, Luessi, Felix, Salmen, Anke, Gisevius, Barbara, Klotz, Luisa, Korsukewitz, Catharina, Berthele, Achim, Groppa, Sergiu, Then Bergh, Florian, Wildemann, Brigitte, Bayas, Antonois, Tumani, Hayrettin, Meuth, Sven G., Trebst, Corinna, Zettl, Uwe K., Paul, Friedemann, Heesen, Christoph, Kuempfel, Tania, Gold, Ralf, Hemmer, Bernhard, Zipp, Frauke, Wiendl, Heinz, and Lünemann, Jan D.

Abstract

Background Obesity reportedly increases the risk for developing multiple sclerosis (MS), but little is known about its association with disability accumulation. Methods This nationwide longitudinal cohort study included 1066 individuals with newly diagnosed MS from the German National MS cohort. Expanded Disability Status Scale (EDSS) scores, relapse rates, MRI findings and choice of immunotherapy were compared at baseline and at years 2, 4 and 6 between obese (body mass index, BMI ≥30 kg/m2) and non-obese (BMI <30 kg/m2) patients and correlated with individual BMI values. Results Presence of obesity at disease onset was associated with higher disability at baseline and at 2, 4 and 6 years of follow-up (p<0.001). Median time to reach EDSS 3 was 0.99 years for patients with BMI ≥30 kg/m2 and 1.46 years for non-obese patients. Risk to reach EDSS 3 over 6 years was significantly increased in patients with BMI ≥30 kg/m2 compared with patients with BMI <30 kg/m2 after adjustment for sex, age, smoking (HR 1.87; 95% CI 1.3 to 2.6; log-rank test p<0.001) and independent of disease-modifying therapies. Obesity was not significantly associated with higher relapse rates, increased number of contrast-enhancing MRI lesions or higher MRI T2 lesion burden over 6 years of follow-up. Conclusions Obesity in newly diagnosed patients with MS is associated with higher disease severity and poorer outcome. Obesity management could improve clinical outcome of MS.

Published
2022

85. Subcortical volumes as early predictors of fatigue in multiple sclerosis

Author

Fleischer, Vinzenz, Ciolac, Dumitru, Gonzalez-Escamilla, Gabriel, Grothe, Matthias, Strauss, Sebastian, Molina Galindo, Lara S, Radetz, Angela, Salmen, Anke, Lukas, Carsten, Klotz, Luisa, Meuth, Sven G, Bayas, Antonios, Paul, Friedemann, Hartung, Hans-Peter, Heesen, Christoph, Stangel, Martin, Wildemann, Brigitte, Bergh, Florian Then, Tackenberg, Bj��rn, K��mpfel, Tania, Zettl, Uwe K, Knop, Matthias, Tumani, Hayrettin, Wiendl, Heinz, Gold, Ralf, Bittner, Stefan, Zipp, Frauke, Groppa, Sergiu, and Muthuraman, Muthuraman

Subjects
Adult, Male, Multiple Sclerosis, 610 Medizin, 610 Medicine & health, Cohort Studies, Young Adult, Predictive Value of Tests, Pons, 610 Medical sciences, Humans, Longitudinal Studies, ddc:610, Gray Matter, Fatigue, Putamen, Brain, Middle Aged, Prognosis, Magnetic Resonance Imaging, Cross-Sectional Studies, Neurology, Female, Neurology (clinical), Nerve Net, Function and Dysfunction of the Nervous System, Demyelinating Diseases, Follow-Up Studies
Abstract

OBJECTIVE Fatigue is a frequent and severe symptom in multiple sclerosis (MS), but its pathophysiological origin remains incompletely understood. We aimed to examine the predictive value of subcortical gray matter volumes for fatigue severity at disease onset and after four years by applying structural equation modeling (SEM). METHODS This multi-center cohort study included 601 treatment-naive MS patients after the first demyelinating event. All patients underwent a standardized 3T MRI protocol. A subgroup of 230 patients with available clinical follow-up data after four years was also analyzed. Associations of subcortical volumes (included into SEM) with MS-related fatigue were studied regarding their predictive value. In addition, subcortical regions that have a central role in the brain network (hubs) were determined through structural covariance network (SCN) analysis. RESULTS Predictive causal modeling identified volumes of the caudate (s [standardized path coefficient]=0.763, p=0.003 [left]; s=0.755, p=0.006 [right]), putamen (s=0.614, p=0.002 [left]; s=0.606, p=0.003 [right]) and pallidum (s=0.606, p=0.012 [left]; s=0.606, p=0.012 [right]) as prognostic factors for fatigue severity in the cross-sectional cohort. Moreover, the volume of the pons was additionally predictive for fatigue severity in the longitudinal cohort (s=0.605, p=0.013). In the SCN analysis, network hubs in patients with fatigue worsening were detected in the putamen (p=0.008 [left]; p=0.007 [right]) and pons (p=0.0001). INTERPRETATION We unveiled predictive associations of specific subcortical gray matter volumes with fatigue in an early and initially untreated MS cohort. The colocalization of these subcortical structures with network hubs suggests an early role of these brain regions in terms of fatigue evolution. This article is protected by copyright. All rights reserved.

Published
2022
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99. Assessment of microRNA-related SNP effects in the 3′ untranslated region of the IL22RA2 risk locus in multiple sclerosis

Author

Lill, Christina M., Schilling, Marcel, Ansaloni, Sara, Schröder, Julia, Jaedicke, Marian, Luessi, Felix, Schjeide, Brit-Maren M., Mashychev, Andriy, Graetz, Christiane, Akkad, Denis A., Gerdes, Lisa-Ann, Kroner, Antje, Blaschke, Paul, Hoffjan, Sabine, Winkelmann, Alexander, Dörner, Thomas, Rieckmann, Peter, Steinhagen-Thiessen, Elisabeth, Lindenberger, Ulman, Chan, Andrew, Hartung, Hans-Peter, Aktas, Orhan, Lohse, Peter, Buttmann, Mathias, Kümpfel, Tania, Kubisch, Christian, Zettl, Uwe K., Epplen, Joerg T., Zipp, Frauke, and Bertram, Lars

Published
2014
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100. Association of obesity with disease outcome in multiple sclerosis.

Author

Lutfullin, Isabel, Eveslage, Maria, Bittner, Stefan, Antony, Gisela, Flaskamp, Martina, Luessi, Felix, Salmen, Anke, Gisevius, Barbara, Klotz, Luisa, Korsukewitz, Catharina, Berthele, Achim, Groppa, Sergiu, Then Bergh, Florian, Wildemann, Brigitte, Bayas, Antonios, Tumani, Hayrettin, Meuth, Sven G., Trebst, Corinna, Zettl, Uwe K., and Paul, Friedemann

Subjects
MULTIPLE sclerosis, MORBID obesity, OBESITY
Abstract

Background: Obesity reportedly increases the risk for developing multiple sclerosis (MS), but little is known about its association with disability accumulation.Methods: This nationwide longitudinal cohort study included 1066 individuals with newly diagnosed MS from the German National MS cohort. Expanded Disability Status Scale (EDSS) scores, relapse rates, MRI findings and choice of immunotherapy were compared at baseline and at years 2, 4 and 6 between obese (body mass index, BMI ≥30 kg/m2) and non-obese (BMI <30 kg/m2) patients and correlated with individual BMI values.Results: Presence of obesity at disease onset was associated with higher disability at baseline and at 2, 4 and 6 years of follow-up (p<0.001). Median time to reach EDSS 3 was 0.99 years for patients with BMI ≥30 kg/m2 and 1.46 years for non-obese patients. Risk to reach EDSS 3 over 6 years was significantly increased in patients with BMI ≥30 kg/m2 compared with patients with BMI <30 kg/m2 after adjustment for sex, age, smoking (HR 1.87; 95% CI 1.3 to 2.6; log-rank test p<0.001) and independent of disease-modifying therapies. Obesity was not significantly associated with higher relapse rates, increased number of contrast-enhancing MRI lesions or higher MRI T2 lesion burden over 6 years of follow-up.Conclusions: Obesity in newly diagnosed patients with MS is associated with higher disease severity and poorer outcome. Obesity management could improve clinical outcome of MS. [ABSTRACT FROM AUTHOR]

Published
2023
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