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364 results on '"Zeng, Jianguo"'

56. Biosynthesis, regulation, and domestication of bitterness in cucumber

Author

Shang, Yi, Ma, Yongshuo, Zhou, Yuan, Zhang, Huimin, Duan, Lixin, Chen, Huiming, Zeng, Jianguo, Zhou, Qian, Wang, Shenhao, Gu, Wenjia, Liu, Min, Ren, Jinwei, Gu, Xingfang, Zhang, Shengping, Wang, Ye, Yasukawa, Ken, Bouwmeester, Harro J., Qi, Xiaoquan, Zhang, Zhonghua, Lucas, William J., and Huang, Sanwen

Published
2014

57. Protopine Alleviates Dextran Sodium Sulfate-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Regulating Intestinal Microbiota.

Author

Yue, Meishan, Huang, Jialu, Ma, Xiaolan, Huang, Peng, Liu, Yisong, and Zeng, Jianguo

Subjects
ULCERATIVE colitis, GUT microbiome, DEXTRAN, ISOQUINOLINE alkaloids, INFLAMMATORY bowel diseases, INTESTINES, CHINESE medicine
Abstract

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD), and its pathogenesis is related to intestinal mucosal barrier damage and gut microbiota imbalance. Protopine (PRO), an isoquinoline alkaloid, is one of the main anti-inflammatory ingredients of traditional Chinese medicine Macleaya cordata (Willd.) R. Br. This study investigated the effects of PRO on the intestinal mucosal barrier and gut microbiota in dextran sodium sulfate (DSS)-induced colitis mice. C57BL/6J mice were treated with 3% DSS in drinking water to induce acute colitis, while PRO was administered orally once daily for 7 days. The results showed that PRO administration significantly alleviated the symptoms of DSS-induced colitis in mice and inhibited the expression of inflammation-related genes. In addition, PRO restored the integrity of the intestinal barrier in colitis mice by restoring colonic mucin secretion and promoting the expression of tight junction proteins. Furthermore, PRO alleviated the DSS-induced gut microbiota dysbiosis by decreasing the abundance of Proteobacteria, Escherichia-Shigella and Enterococcus, as well as enhancing the abundance of beneficial bacteria, such as Firmicutes and Akkermansia. These findings suggested that PRO effectively alleviated DSS-induced ulcerative colitis by suppressing the expression of inflammation-related genes, maintaining the intestinal mucosal barrier and regulating the intestinal microbiota. [ABSTRACT FROM AUTHOR]

Published
2023
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59. Photoredox catalysed reductive aminomethylation of quaternary benzophenanthridine alkaloids

Author

Wang, Xinhao, Wang, Lin, Zhang, Jingxuan, Liu, Yisong, Xie, Hongqi, Zeng, Jianguo, and Cheng, Pi

Subjects
Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry
Abstract

Reduction of C = N double bond is the most important phase I metabolism process of quaternary benzophenanthridine alkaloids (QBAs). Inspired by the NADPH mediated reduction in QBAs, a visible-light promoted reductive aminomethylation of QBAs for synthesis of 6-substituted benzophenanthridines was reported using QBAs and N,N-dimethylaniline as coupling partners in this study. An α-amino radical that derived from QBAs was supposed to be the key intermediate in this visible-light promoted reductive aminomethylation reaction.

Published
2022

62. Effects of sulfated β-glucan from Saccharomyces cerevisiae on growth performance, antioxidant ability, nonspecific immunity, and intestinal flora of the red swamp crayfish (Procambarus clarkii)

Author

Huang, Qi, primary, Zhu, Yiling, additional, Yu, Jie, additional, Fang, Liu, additional, Li, Yana, additional, Wang, Mi, additional, Liu, Jiali, additional, Yan, Pupu, additional, Xia, Jinjin, additional, Liu, Guoping, additional, Yang, Xiaolin, additional, Zeng, Jianguo, additional, Guo, Liwei, additional, and Ruan, Guoliang, additional

Published
2022
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71. Magnolol additive improves growth performance of Linwu ducklings by modulating antioxidative status

Author

Lin, Qian, primary, Liu, Yang, additional, Peng, Simin, additional, Liu, Chunjie, additional, Lv, Tuo, additional, Liao, Liping, additional, Li, Yinghui, additional, Wang, Yanzhou, additional, Fan, Zhiyong, additional, Wu, Weiguo, additional, Zeng, Jianguo, additional, Qiu, Huajiao, additional, He, Xi, additional, and Dai, Qiuzhong, additional

Published
2021
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73. Effects of Dietary Bacillus and Non-starch Polysaccharase on the Intestinal Microbiota and the Associated Changes on the Growth Performance, Intestinal Morphology, and Serum Antioxidant Profiles in Ducks

Author

Peng, Simin, primary, Wang, Xin, additional, Wang, Yuyu, additional, Lv, Tuo, additional, Zhao, Haohan, additional, Wang, Yanzhou, additional, Zhu, Siyuan, additional, Qiu, Huajiao, additional, Zeng, Jianguo, additional, Dai, Qiuzhong, additional, and Lin, Qian, additional

Published
2021
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84. A genome assembly of decaploid Houttuynia cordataprovides insights into the evolution of Houttuyniaand the biosynthesis of alkaloids

Author

Huang, Peng, Li, Zhu, Wang, Huan, Huang, Jinqiang, Tan, Guifeng, Fu, Yue, Liu, Xiubin, Zheng, Shang, Xu, Peng, Sun, Mengshan, and Zeng, Jianguo

Abstract

Houttuynia cordataThunb., commonly known as yuxingcao in China, is known for its characteristic fishy smell and is widely recognized as an important herb and vegetable in many parts of Asia. However, the lack of genomic information on H. cordatalimits the understanding of its population structure, genetic diversity, and biosynthesis of medicinal compounds. Here we used single-molecule sequencing, Illumina paired-end sequencing, and chromosome conformation capture technology to construct the first chromosome-scale decaploid H. cordatareference genome. The genome assembly was 2.63 Gb in size, with 1348 contigs and a contig N50 of 21.94 Mb further clustered and ordered into 88 pseudochromosomes based on Hi-C analysis. The results of genome evolution analysis showed that H. cordata underwent a whole-genome duplication (WGD) event ~17 million years ago, and an additional WGD event occurred 3.3 million years ago, which may be the main factor leading to the high abundance of multiple copies of orthologous genes. Here, transcriptome sequencing across five different tissues revealed significant expansion and distinct expression patterns of key gene families, such as l-amino acid/l-tryptophan decarboxylase and strictosidine synthase, which are essential for the biosynthesis of isoquinoline and indole alkaloids, along with the identification of genes such as TTM3, which is critical for root development. This study constructed the first decaploid medicinal plant genome and revealed the genome evolution and polyploidization events of H. cordata.

Published
2024
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93. Biomimetic synthesis of 6-substituted dihydrobenzophenanthridine alkaloids based on visible-light promoted radical addition reaction.

Author

Cheng, Pi, Wang, Wei, Wang, Xinhao, Wang, Lin, Liu, Wei, and Zeng, Jianguo

Subjects
BIOMIMETIC synthesis, ADDITION reactions, MICHAEL reaction
Abstract

Oxidative C–H functionalization of dihydrobenzophenanthridines catalyzed by dihydrobenzophenanthridine oxidase (DBOX) is believed to be the key step involved in the biosynthetic pathway of some novel 6-substituted benzophenanthridine alkaloids. In this study, a visible-light promoted biomimetic synthesis of 6-substituted benzophenanthridines was reported under photoredox-neutral conditions. α-Amino radical that derived from dihydrobenzophenanthridines was supposed to be the key intermediate in this visible-light promoted radical-type Michael addition reaction. [ABSTRACT FROM AUTHOR]

Published
2022
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