276 results on '"Zehra B"'
Search Results
52. Lifestyle Changes and COVID-19 Related Perceptions of Turkish Healthcare Workers
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Zehra Batu, Mikail Batu, Akan Yanık, Hülya Oğur, Simge Kavcar, and Serhat Bolat
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History of scholarship and learning. The humanities ,AZ20-999 ,Social Sciences - Abstract
This study seeks to investigate and understand the perceptions of and lifestyle changes adopted by healthcare workers (HCWs) in Turkey who were on the front line of the fight against the outbreak of COVID-19. A total of 33 female HCWs with bachelor’s degrees were included in the study. In-depth interview techniques were used. The data analysis was performed with MAXQDA 2020 qualitative data analysis package program. The female HCWs perceived COVID-19 as rapidly contagious, deadly, dangerous, and long-term. Their perception as to the cause of the outbreak was akin to conspiracy thoughts such as bioweapon. In addition, the study determined that social media was the preferred medium for getting news because the news given in the traditional media was not trusted. It was seen that the attitude of participants regarding the preventive measures was in line with the recommendations of international organizations. In terms of lifestyle changes, for example, the dietary habits and physical activity levels of all the HCW participants, changed and online environments were used for communication/socialization. Those HCW participants who smoked, stated that smoking increased the risk and severity of COVID-19, and they declared an increase in the amount of their use. Those HCW participants who consumed alcohol, reported that alcohol consumption increased during the period of the outbreak in order to maintain socialization and relaxation. Those HCW participants who did not smoke or drink alcohol mentioned that they did not intend to start. This study contributes to an understanding of the impact on HCWs of significant health events especially in terms of their perceptions of and their lifestyle changes as a result of such health events.
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- 2023
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53. The Outcomes of Direct-acting Antiviral Treatment in 177 Patients with Hepatitis C Virus: A Single-center Experience
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Ayşin KILINÇ TOKER, Ayşe TURUNÇ ÖZDEMİR, Esma Eren ERYILMAZ, Duygu ÇERÇİOĞLU ÖZDEMİR, Deniz KALAMAK GÜZEL, Tuğba TOK, Zehra BEŞTEPE DURSUN, Musa GÖKSU, and İlhami ÇELİK
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direct-acting antivirals ,sustained viral response ,hepatitis c ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Introduction: Hepatitis C virus (HCV) is an essential cause of hepatitis, cirrhosis, and hepatocellular carcinoma. Hepatitis C virus is a global public health problem. “Field practice” in patients with HCV infection is significant for directly observing treatment responses with antiviral agents. Our study aimed to evaluate the effectiveness of direct-acting antivirals (DAAs) in Kayseri City Hospital. Materials and Methods: Our retrospective observational study, conducted at a single center, evaluated HCV-RNA-positive patients who were genotyped between January 2019 and April 2023. Demographic characteristics, laboratory values, treatment agents, and HCV genotypes of the patients were recorded using the hospital information system. The primary endpoint of the study was the sustained virological response 12 weeks after treatment. Results: In our five-year study involving 177 patients, the average age was 60.6, and 55.4% (n=98) of the participants were male. Genotype 1b was the most common at 51.8%, followed by genotype 4 at 19.2%. Additionally, six of 11 Syrian patients were identified as genotype 3. The glecaprevir/pibrentasvir combination was administered to 91.5% of the patients, while the sofosbuvir/velpatasvir/voxilaprevir combination was started in 8.5% (n=15). A total of 6.2% of the patients had prior treatment experience. At week 12, all patients exhibited negative HCV-RNA levels, resulting in a 100% treatment success rate. Conclusion: These two DAAs currently used in HCV infection were highly effective. The prevalence of genotype 4 in our region was higher than the national HCV genotype distribution.
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- 2023
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54. Analyzing a Text Within its Period: Why Did We Misunderstand Masdariyecizade Hüseyin Efendi’s Treatise on Teslıs-i Zaviye and Kavs?
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Zehra Bilgin
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trisecting the angle ,teslīs-i zāviye ,masdariyecizāde hüseyin efendi ,mühendishāne ,salih zeki bey ,Islam ,BP1-253 - Abstract
Masdariyecizāde Hüseyin Efendi, one of the lecturers at Mühendishāne-i Berrī-i Hümāyūn (The Imperial School of Military Engineering), wrote a treatise in h.1238/c.1822 on the ancient problem of trisecting an angle smaller than ninety degrees using Euclidean geometry. This famous problem has its roots in the ancient Greek. The treatise contains an assumed solution to the problem by using tools of Euclidean geometry, a straightedge (an unmarked ruler) and a compass. The proof is recorded under the signatures indicating the approval of the engineering faculty. The available academic literature on this treatise generally contains comments denigrating the work, the author and the scholarly environment of the period based on the claim that it had already been proven at the time Hüseyin Efendi published his treatise, that a positive result could not be reached with the limited tools used in the solution. All this contemporary research is originated from a sole source, Salih Zeki Bey’s articles on the subject written a century ago, the accuracy of which is debatable in terms of its contents. This study focuses on the claims based on this common source as well as the history of the solution to the problem, and thus provides a correction to the erroneous information on the subject.
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- 2023
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55. Son Kilometre Koli Teslimatı Literatür Taraması: Yükselen Eğilim ve İlgili Teknolojilere Bir Bakış
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Mehmet Soysal, Mine Ömürgönülşen, and Zehra Burçin Kanık
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koli teslimatı ,son kilometre lojistiği ,literatür taraması ,yükselen eğilim ve teknolojiler ,Industrial productivity ,HD56-57.5 - Abstract
Amaç: Bu çalışmanın amacı, son kilometre koli teslimatı alanıyla ilgili sistematik bir literatür taraması gerçekleştirmek ve literatürde yer alan yükselen eğilim ve teknolojilere bir bakış açısı sunmaktır. Yöntem: Çalışma kapsamında sistematik bir literatür taraması gerçekleştirilerek tanımlayıcı analizler gerçekleştirilmiş ve son kilometre koli teslimatı yazını kapsamında literatürde yer verilen yeni iş modelleri, yükselen eğilim ve teknolojiler belirlenerek gruplanmış; detaylı bir şekilde açıklanarak tanıtılmış ve her birinin sağladığı potansiyel faydalar ifade edilmiştir. Bulgular: İlgili literatür taramasının analizlerinde son kilometre koli teslimatı kavramıyla ilgili yayın sayısında önemli bir artış görülmektedir. Çalışmaların büyük çoğunluğu, nicel teknikleri uygulamaktadır. Literatür taraması neticesinde, en çok yayın yapılan dergiler ve dergilerin etki faktörlerine de yer verilmiştir. Üç gruba ayrılan ve alt başlıklarıyla detaylandırılan eğilim ve teknolojiler ise teknoloji odaklı teslimat seçenekleri, çevre dostu teslimat uygulamaları ve yeni iş modelleridir. Özgünlük: Bilinebildiği kadarıyla bu çalışma, son kilometre koli teslimatı alanında bu kadar detaylı incelenen ilk Türkçe literatür taramasıdır.
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- 2023
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56. Shared decision making in patients at risk of cancer: the role of domain and numeracy
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Zehra B. Omer, Talya Miron-Shatz, Elisa Ozanne, Yaniv Hanoch, and Jonathan J. Rolison
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Adult ,Decision Making ,Control (management) ,Breast Neoplasms ,Domain (software engineering) ,Cancer Genetics Network ,Risk Factors ,Numeracy ,Neoplasms ,Surveys and Questionnaires ,medicine ,Humans ,Genetic Predisposition to Disease ,In patient ,business.industry ,Public Health, Environmental and Occupational Health ,Cancer ,Patient Preference ,Middle Aged ,medicine.disease ,Preference ,Scale (social sciences) ,Female ,business ,Original Research Papers ,Clinical psychology - Abstract
Background Shared decision making has become an integral part of medical consultation. Research has, however, reported wide differences in individuals' desires to be involved in the decision-making process, and these differences in preferences are likely to be the result of a number of factors including age, education and numeracy. Objective To investigate whether patients at genetic risk for cancer had preferences for shared decision making that differed depending on medical domain (general health vs. cancer) and whether decision preferences are linked to numeracy abilities. Methods Four hundred and seventy-six women who consented to participate in response to an email sent by a local branch of the U.S.-based Cancer Genetics Network (CGN) to its members. Participants completed the Control Preference Scale, as well as an objective and subjective numeracy scales. Results Decision domain (cancer vs. general health) was not associated with women's preferences for involvement in decision making. Objective and subjective numeracy predicted a preference for decision involvement in general, and only objective numeracy was predictive with regard to cancer. Conclusion Participants were equally likely to state they wanted to play an active, collaborative or passive role in both medical domains (general and cancer). High-numeracy participants were more likely to express a desire for an active role in general and in case they were diagnosed with cancer. Practice implications Health authorities' recommendations to clinicians to include patients in their medical decisions are supported by patients' desires, and clinicians should be cognizant of their patients' preferences as well as their numeracy skills.
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- 2014
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57. MRI-Guided Focused Ultrasound Surgery for Uterine Fibroid Treatment: A Cost-Effectiveness Analysis
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G. Scott Gazelle, Serene S. Srouji, Lesley Meng, J. Shannon Swan, Zehra B. Omer, Fiona M. Fennessy, and Chung Yin Kong
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Adult ,medicine.medical_specialty ,Cost effectiveness ,Uterine fibroids ,Cost-Benefit Analysis ,Ultrasonic Therapy ,medicine.medical_treatment ,Efficiency, Organizational ,Hysterectomy ,Magnetic Resonance Imaging, Interventional ,Article ,Uterine artery embolization ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,health care economics and organizations ,Leiomyoma ,Cost–benefit analysis ,business.industry ,General Medicine ,Cost-effectiveness analysis ,medicine.disease ,Quality-adjusted life year ,Models, Economic ,Uterine Neoplasms ,Female ,Quality-Adjusted Life Years ,Radiology ,business - Abstract
OBJECTIVE. The purpose of this article is to evaluate the cost effectiveness of a treatment strategy for symptomatic uterine fibroids that uses MRI-guided focused ultrasound as a first-line therapy relative to uterine artery embolization (UAE) or hysterectomy. MATERIALS AND METHODS. We developed a decision-analytic model to compare the cost effectiveness of three first-line treatment strategies: MRI-guided focused ultrasound, UAE, and hysterectomy. Treatment-specific short- and long-term utilities, lifetime costs, and quality-adjusted life years (QALYs) were incorporated, allowing us to conduct an incremental cost-effectiveness analysis, using a societal willingness-to-pay (WTP) threshold of $50,000/QALY to designate a strategy as cost effective. Sensitivity analyses were subsequently performed on all key parameters. RESULTS. In the base-case analysis, UAE as a first-line treatment of symptomatic fibroids was the most effective and expensive strategy (22.75 QALYs; $22,968), followed by MRI-guided focused ultrasound (22.73 QALYs; $20,252) and hysterectomy (22.54 QALYs; $11,253). MRI-guided focused ultrasound was cost effective relative to hysterectomy, with an associated incremental cost-effectiveness ratio (ICER) of $47,891/QALY. The ICER of UAE relative to MRI-guided focused ultrasound was $234,565/QALY, exceeding the WTP threshold of $50,000/QALY, therefore rendering MRI-guided focused ultrasound also cost effective relative to UAE. In sensitivity analyses, results were robust to changes in most parameters but were sensitive to changes in probabilities of recurrence, symptom relief, and quality-of-life measures. CONCLUSION. First-line treatment of eligible women with MRI-guided focused ultra-sound is a cost-effective noninvasive strategy. For those not eligible for MRI-guided focused ultra-sound, UAE remains a cost-effective option. These recommendations integrate both the short- and long-term decrements in quality of life associated with the specific treatment modalities.
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- 2014
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58. Trends of etiology and treatment in hepatocellular carcinoma over the years
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Vatansever, Sezgin, primary and Pakoz, Zehra B., additional
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- 2018
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59. The Role of Store Environment Cues on Store Personality and Store Image
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Elif Taşkın and Zehra Bozbay
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store environment ,store personality ,store image ,store preference ,Stimulus-Organism-Response (SOR) model ,Marketing. Distribution of products ,HF5410-5417.5 - Abstract
Purpose – This paper aims to explain the effects of color, lighting, and music as store environment cues on the perceptions among consumers of store personality, store image, and on their own store preferences. Design/Methodology/Approach – An experimental approach was employed to determine these effects, using a between-subjects factorial design including two levels of color, lighting, and music. The data were collected from 600 participants through face-to-face surveys. A video design of a fictional store environment was shown to the subjects and survey questions were applied to eight different experimental groups by providing manipulation control. Results and implications – The results demonstrate that consumer perceptions of store image, store personality, and store preferences differ with changing color, lighting, and music variables. Additionally, these variables differ in their interactions with each other and in their total interactions. Limitations – While the present study sheds light on the influence of color, lighting, and music cues of the fashion store environment on consumer perceptions of store personality and image, as well as their store preferences, interactions between store environment cues and other attributes in stores should also be explored. Originality – This study examines the impact of store environment variables in their different aspects on consumer perceptions of store image and store personality, as well as consumer store preferences, by focusing on Mehrabian and Russell’s (1974) Stimulus-Organism-Response (SOR) model as its theoretical background.
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- 2023
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60. Virtual General Assembly Meetings In Joint Stock Companies With Foreign Capital
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Ebru Şensöz Malkoç and Zehra Badak
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Social Sciences - Published
- 2022
61. Education outcomes of a multisite, virtual, interprofessional training in patient priorities aligned care.
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Ouellet, Jennifer A., Mecca, Marcia C., Tinetti, Mary E., Dindo, Lilian, Kiefer, Lea, Nguyen, Aaron C., Omer, Zehra B., Naik, Aanand D., and Catic, Angela G.
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ONLINE education ,PILOT projects ,EVALUATION of medical care ,GERIATRIC psychiatry ,HOSPITAL medical staff ,ACADEMIC medical centers ,INTERNAL medicine ,CONFIDENCE ,HEALTH occupations students ,GERIATRICS ,PATIENT-centered care ,SATISFACTION ,PHARMACISTS ,T-test (Statistics) ,ABILITY ,TRAINING ,RESEARCH funding ,DESCRIPTIVE statistics ,SCALE analysis (Psychology) ,COMMUNICATION ,INTERDISCIPLINARY education ,MEDICAL practice ,DECISION making in clinical medicine ,THEMATIC analysis ,PATIENT-professional relations ,EDUCATIONAL outcomes ,COVID-19 pandemic ,GOAL (Psychology) ,PALLIATIVE treatment - Abstract
The article explores education outcomes for those receiving training in patient priorities aligned care. The authors report on developing an interactive, virtual training for fellows in geriatric medicine, geriatric psychiatry, palliative care, internal medicine and geriatric pharmacy students studying at the Yale School of Medicine, the Baylor College of Medicine and the Mountain Area Health Education Center. Discussion and results of the project are also offered.
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- 2022
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62. CHANGES IN MUCOSA-ASSOCIATED INVARIANT T CELLS (MAIT), ASSOCIATED CYTOKINES, AND MR-1+ CELL NUMBER AND PHENOTYPE IN THE PERIPHERAL BLOOD OF PEDIATRIC ITP PATIENTS WITH AND WITHOUT ELTROMBOPAG THERAPY
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Ahmet Eken, Metin Çil, Zehra Busra Azizoglu, Ramazan Üzen, Nazly Najat ASAAD, Sahin CALIK, Koray DORTERLER, Enes Mehmet Turkoglu, Yunus Emre DOĞAN, Ebru Yılmaz, Alper Ozcan, Musa Karakükçü, Goksel Leblebisatan, and Ekrem Ünal
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Objective: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia caused by the formation of antibodies against platelets. Mucosa-associated invariant T cells (MAIT), a subset of unconventional T cells present in the blood and mucosa, are activated in an MR-1-mediated manner, respond to certain infections and cytokines and produce various effector cytokines. Case report: In this study, changes in blood MAIT cells were investigated in pediatric ITP patients who received and did not receive Eltrombopag. Twenty healthy volunteers (n:20), 60 untreated, and 16 treated patients (with Eltrombopag) were included in the study. Methodology: PBMCs isolated using the Ficoll-Hypaque density gradient were stained with appropriate surface markers and subjected to flow cytometric analysis. In addition, intracellular cytokine staining was performed to measure the level of IFN-γ, IL17A, IL-22, TNF-α cytokines after PMA/Ionomycin stimulation, and all data were analyzed using FlowJo and GraphPad 8. Results: Independent of Eltrombopag treatment, MAIT cell absolute counts were decreased in ITP patients. CD45RO levels of the CD8+MAIT subtype increased, αβ+ T cells decreased, and γδ+ T cell frequency increased in ITP patients. In patients, the frequency of MAIT cell-derived IFN-γ and TNF-α decreased, MR-1 expression, which is responsible for MAIT cell activation in the CD3−fraction, increased, and this level decreased to the levels in healthy controls in individuals receiving Eltrombopag treatment. Conclusion: The low HLA-DR levels seen in CD3- cells in ITP patients reached the levels of healthy controls in the group receiving Eltrombopag. These results show that the number and activation status of MAIT cells in ITP patients change and Eltrombopag treatment modulates MAIT cell activity.
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- 2023
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63. Evaluation of Cortical Thicknesses and Bone Density Values of Mandibular Canal Borders and Coronal Site of Alveolar Crest
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Emel Tuğba Ataman-Duruel, Zehra Beycioğlu, Doğukan Yılmaz, Samir Goyushov, Tansu Çimen, Onurcem Duruel, Hasan Güney Yılmaz, and Tolga Fikret Tözüm
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bone density ,dental implants ,mandibular canal ,tomography ,Dentistry ,RK1-715 - Abstract
Objectives: The objectives of this retrospective study are to measure the amount of the alveolar crest cortication and cortication around the mandibular canal, and to evaluate bone density values of alveolar crest, cortication around mandibular canal, and possible implant placement area for edentulous sites. Material and Methods: Six hundred forty-two cone-beam computed tomography scans from 642 subjects were evaluated in four centers. Cortical thicknesses of alveolar crest and mandibular canal cortical borders (buccal, lingual, apical, and coronal) in each mandibular posterior teeth region were measured. Bone density of alveolar crest and mandibular canal cortical borders (buccal, lingual, apical, and coronal) in each mandibular posterior teeth region were recorded. The correlations between numeric variables were investigated using Pearson’s correlation test. Results: The largest cortical border of the canal was measured 1.1 (SD 0.71) mm at the left second molar area and in coronal side of the mandibular canal (MC). Left and right first premolar regions showed higher bone density values compared to the other sites in all bone density values evaluations. The buccal side of the canal at the right first premolar region showed the highest bone density values (832.32 [SD 350.01]) while the coronal side of the canal at the left second molar region showed the lowest (508.75 [SD 225.47]). The bone density of possible implant placement area at the both left (692.25 [SD 238.25]) and right (604.43 [SD 240.92]) edentulous first premolar showed the highest values. Positive correlations between the bone density values of alveolar crest and the coronal side of MC were found in molar and left second premolar regions (P < 0.05). Conclusions: Results may provide information about the amount of cortication and bone densities tooth by tooth for posterior mandible to surgeons for planning the treatment precisely.
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- 2023
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64. 130 Poster - The synergistic action of isolated sesquiterpene with cisplatin against non-small cell lung cancer cells
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Ahmed, A. and Zehra, B.
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- 2020
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65. Abstract P4-11-03: Single nucleotide polymorphism testing for breast cancer risk assessment: patient trust and willingness to pay
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Talya Miron-Shatz, Zehra B. Omer, Elissa M. Ozanne, Yaniv Hanoch, Rebecca Howe, and C Thorsen
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Gynecology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Genetic counseling ,BRCA mutation ,Context (language use) ,medicine.disease ,Cancer Genetics Network ,Breast cancer ,Oncology ,Willingness to pay ,Family medicine ,medicine ,SNP ,Personalized medicine ,business - Abstract
Background: The field of breast cancer risk assessment is advancing rapidly with recent discoveries about risk conferring single nucleotide polymorphisms (SNPs). While these discoveries can promote personalized medicine, they are often brought to the market with direct to consumer (DTC) testing before data can support their widespread use and before reliable options for dealing with testing outcomes can be offered. In this context, and knowing that patients often misunderstand risk information, it is unclear how patients will respond to these options. Methods: We surveyed high risk women's interest in SNP testing. Participants were recruited from the Cancer Genetics Network (CGN), a national network of cancer centers that maintains a database of individuals with a family history of cancer. Participants were asked to answer questions regarding their interest in SNP testing including: whether they trust it, how much they would be willing to pay for testing, how they prefer to be tested, and how they would proceed with information identifying them as below or above average risk. Results: 189 women without a history of breast cancer or SNP testing completed the questionnaire. The average age of the participants was 49, ranging from 30 to 65. All participants had at least one relative with breast or ovarian cancer. 13% had previously tested positive for a BRCA mutation, and 33% had received BRCA testing. Most women (90%) did not know what SNP testing was prior to the survey. Once SNP testing was described, 68% of women were interested in DTC SNP testing; at the same time, only 38% of the participants reported that they trusted DTC SNP testing. Conclusion: While our results show that women are interested in DTC SNP testing, their willingness to pay is lower than the DTC cost (∼$300). Involvement of genetic counselors and providers in SNP testing discussions may be needed to overcome the current lack of trust of DTC testing among patients. Many women showed interest in lifestyle interventions, suggesting that these interventions should be incorporated as part of standard follow-up recommendations. When identified by SNP testing as “below average” risk, women do not seem to trust the results enough to forego regular mammograms. As DTC testing becomes more common, and as more SNP tests become available, it will be necessary for the medical community to address patients' interest in these tests and to assist in interpreting results. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P4-11-03.
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- 2012
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66. Using Radiation Risk Models in Cancer Screening Simulations: Important Assumptions and Effects on Outcome Projections
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G. Scott Gazelle, Zehra B. Omer, Pamela M. McMahon, Kathryn P. Lowry, Pari V. Pandharipande, Janie M. Lee, Chung Yin Kong, and Jonathan D. Eisenberg
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Adult ,Male ,medicine.medical_specialty ,Lung Neoplasms ,Neoplasms, Radiation-Induced ,Cost effectiveness ,Breast Neoplasms ,Radiation Dosage ,Risk Assessment ,Outcome (game theory) ,Outcome Assessment, Health Care ,Cancer screening ,Medical imaging ,medicine ,Humans ,Mammography ,False Positive Reactions ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Early Detection of Cancer ,Original Research ,Aged ,medicine.diagnostic_test ,business.industry ,Incidence ,Age Factors ,Middle Aged ,Radiation exposure ,Radiation risk ,Female ,Radiography, Thoracic ,Tomography, X-Ray Computed ,Risk assessment ,business ,Monte Carlo Method ,Algorithms - Abstract
To evaluate the effect of incorporating radiation risk into microsimulation (first-order Monte Carlo) models for breast and lung cancer screening to illustrate effects of including radiation risk on patient outcome projections.All data used in this study were derived from publicly available or deidentified human subject data. Institutional review board approval was not required. The challenges of incorporating radiation risk into simulation models are illustrated with two cancer screening models (Breast Cancer Model and Lung Cancer Policy Model) adapted to include radiation exposure effects from mammography and chest computed tomography (CT), respectively. The primary outcome projected by the breast model was life expectancy (LE) for BRCA1 mutation carriers. Digital mammographic screening beginning at ages 25, 30, 35, and 40 years was evaluated in the context of screenings with false-positive results and radiation exposure effects. The primary outcome of the lung model was lung cancer-specific mortality reduction due to annual screening, comparing two diagnostic CT protocols for lung nodule evaluation. The Metropolis-Hastings algorithm was used to estimate the mean values of the results with 95% uncertainty intervals (UIs).Without radiation exposure effects, the breast model indicated that annual digital mammography starting at age 25 years maximized LE (72.03 years; 95% UI: 72.01 years, 72.05 years) and had the highest number of screenings with false-positive results (2.0 per woman). When radiation effects were included, annual digital mammography beginning at age 30 years maximized LE (71.90 years; 95% UI: 71.87 years, 71.94 years) with a lower number of screenings with false-positive results (1.4 per woman). For annual chest CT screening of 50-year-old females with no follow-up for nodules smaller than 4 mm in diameter, the lung model predicted lung cancer-specific mortality reduction of 21.50% (95% UI: 20.90%, 22.10%) without radiation risk and 17.75% (95% UI: 16.97%, 18.41%) with radiation risk.Because including radiation exposure risk can influence long-term projections from simulation models, it is important to include these risks when conducting modeling-based assessments of diagnostic imaging.
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- 2012
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67. P5-15-01: Words Matter: Influence of DCIS Diagnosis Terminology on Patient Treatment Decisions
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Zehra B. Omer, Elissa M. Ozanne, ES Hwang, and Laura J. Esserman
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Gynecology ,Cancer Research ,medicine.medical_specialty ,Pediatrics ,business.industry ,medicine.medical_treatment ,Cancer ,Retrospective cohort study ,Ductal carcinoma ,medicine.disease ,Systemic therapy ,Preference ,Prostate cancer ,Breast cancer ,Oncology ,medicine ,skin and connective tissue diseases ,business ,Watchful waiting - Abstract
Background: Treatment of ductal carcinoma in-situ (DCIS) poses significant challenges. Although retrospective studies suggest that most cases of low grade DCIS will never progress to invasive disease, it remains difficult to accurately identify those patients at greatest risk. In this situation where many diagnosed tumors could follow an indolent course for the patient's lifetime, both systemic therapy and watchful waiting could be reasonable options, similar to those currently offered to patients with early prostate cancer. One strategy that has been suggested to reduce overtreatment is to use terms other than “ductal carcinoma in situ” when explaining a diagnosis of DCIS to a patient. In the current study, we have investigated the effect of terminology on women's stated treatment preference for DCIS. Methods: Women 40–65 years of age were recruited from a database of volunteers at an academic hospital. Subjects with a personal history of breast cancer were excluded. Endpoints were gathered from a web-based survey. Each subject was presented with three different scenarios, each of which used a different terminology for DCIS: non-invasive breast cancer, breast lesion, and abnormal cells. The scenarios included a detailed explanation of the risks and benefits of three treatment options: surgery, systemic treatment only and active surveillance. After reading each scenario, the subject was asked to choose among the treatment options and to explain her choice. Results: 187 subjects completed the survey. More women chose active surveillance when DCIS was described using the terms “abnormal cells” or “breast lesion” than using the term “non-invasive cancer” (Table 1). The majority of women (97/187, 52%) changed their treatment preference when a different term was used to describe DCIS. Of the 97 women who changed their treatment preference, 47 (48%) chose surgery when the term “non-invasive cancer” was used to describe DCIS, but chose a less invasive treatment when “cancer” was not used in the diagnosis. Of 90 people who did not change their treatment preference, 39 (43%) chose active surveillance. Among the three treatments, the percent of women who chose surgery was the highest (84/187; 46%) when the term “non-invasive cancer” was used. 47/84 (56%) of the women who chose surgery when using the term “non-invasive breast cancer” changed their treatment preference when a different term was used. 36/84 (43%) switched to active surveillance while 11/84 (13%) switched to medication. Conclusion: These results support that the specific terminology used to explain a diagnosis of DCIS influences patients’ treatment preference. Moreover, we found that women may entertain treatment preferences other than surgery for DCIS when the tradeoffs of each choice are clearly explained. Avoiding the word “cancer” in the diagnosis may offer a strategy that reduces fear-based treatment decisions and may reduce the burden of overtreatment for DCIS. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-15-01.
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- 2011
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68. Gastrostomy in Hospitalized Patients with Acute Stroke: 'NöroTek' Turkey Point Prevalence Study Subgroup Analysis
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Mehmet Akif Topçuoğlu, Atilla Özcan Özdemir, Özlem Aykaç, Aysel Milanoğlu, Mustafa Gökçe, Songül Bavli, Murat Çabalar, Vildan Yayla, Hacı Ali Erdoğan, Ayça Özkul, Aygül Güneş, Bahar Değirmenci, Ufuk Aluçlu, Hasan Hüseyin Kozak, Levent Güngör, Mücahid Erdoğan, Zeynep Özdemir Acar, Utku Cenikli, Yüksel Kablan, Arda Yılmaz, Hamit Genç, Bijen Nazliel, Hale Batur Çağlayan, Elif Sarıönder Gencer, Halil Ay, Hayri Demirbaş, Özlem Akdoğan, Ufuk Emre, Özlem Kayım Yıldız, Aslı Bolayır, Turgay Demir, Zeynep Tanrıverdi, Ülgen Yalaz Tekan, Çetin Kürşad Akpınar, Esra Özkan, Faik İlik, Hadiye Şirin, Ayşe Güler, Halil Önder, Hesna Bektaş, Levent Öcek, Mustafa Bakar, Nedim Ongun, Yakup Krespi, Canan Togay Işıkay, Eda Aslanbaba, Mine Sorgun, Erdem Gürkaş, Hasan Hüseyin Karadereli, İpek Midi, İrem İlgezdi, Adnan Burak Bilgiç, Şener Akyol, M. Tuncay Epçeliden, Murat Mert Atmaca, Oğuzhan Kurşun, Onur Keskin, Pınar Bekdik Şirinocak, Recep Baydemir, Merve Akçakoyunlu, Şerefnur Öztürk, Tuğba Özel, Ali Ünal, Babür Dora, Vedat Ali Yürekli, Zülfikar Arlıer, Alper Eren, Ayşe Yılmaz, Ayşin Kısabay, Bilgehan Acar, Birgül Baştan, Zeynep Acar, Buket Niflioğlu, Bülent Güven, Dilaver Kaya, Nazire Afşar, Duran Yazıcı, Emrah Aytaç, Erdem Yaka, Eren Toplutaş, Eylem Değirmenci, Fatma Birsen İnce, Gülseren Büyükşerbetçi, İsa Aydın, Mustafa Çetiner, Mustafa Şen, Nilda Turgut, Nilüfer Kale, Eda Çoban, Nilüfer Yeşilot, Esme Ekizoğlu, Özgü Kizek, Özlem Birgili, Recep Yevgi, Refik Kunt, Semih Giray, Sinem Yazıcı Akkaş, Songül Şenadım, Tahir Yoldaş, Talip Asil, Taşkın Duman, Tuğrul Atasoy, Bilge Piri Çınar, Tülin Demir, Ufuk Can, Yaprak Özüm Ünsal, Neslihan Eşkut, Yıldız Aslan, Demet Funda Baş, Ufuk Şener, Zahide Yılmaz, Zehra Bozdoğan, Zekeriya Alioğlu, and Ethem Murat Arsava
- Subjects
stroke ,intracerebral hemorrhage ,malnutrition ,dysphagia ,flash mob ,Medicine ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective: Nutritional status assessment, dysphagia evaluation and enteral feeding decision are important determinants of prognosis in acute neurovascular diseases. Materials and Methods: NöroTek is a point prevalence study conducted with the participation of 87 hospitals spread across all health sub regions of Turkey conducted on 10-May-2018 (World Stroke Awareness Day). A total of 972 hospitalized neurovascular patients [female: 53%, age: 69+-14; acute ischemic stroke in 845; intracerebral hematoma (ICH) in 119 and post-resuscitation encephalopathy (PRE) in 8] with complete data were included in this sub-study. Results: Gastrostomy was inserted in 10.7% of the patients with ischemic stroke, 10.1% of the patients with ICH and in 50% of the patients with PRE. Independent predictors of percutaneous endoscopic gastrostomy (PEG) administration were The National Institutes of Health Stroke Scale score at admission [exp (β): 1.09 95% confidence interval (CI): 1.05-1.14, per point] in ischemic stroke; and mechanical ventilation in ischemic [exp (β): 6.18 (95% CI: 3.16-12.09)] and hemorrhagic strokes [exp (β): 26.48 (95% CI: 1.36-515.8)]. PEG was found to be a significant negative indicator of favorable (modified Rankin's scale score 0-2) functional outcome [exp (β): 0.032 (95% CI: 0.004-0.251)] but not of in-hospital mortality [exp (β): 1.731 (95% CI: 0.785-3.829)]. Nutritional and swallowing assessments were performed in approximately two-thirds of patients. Of the nutritional assessments 69% and 76% of dysphagia assessments were completed within the first 2 days. Tube feeding was performed in 39% of the patients. In 83.5% of them, tube was inserted in the first 2 days; 28% of the patients with feeding tube had PEG later. Conclusion: The NöroTek study provided the first reliable and large-scale data on key quality metrics of nutrition practice in acute stroke in Turkey. In terms of being economical and accurate it makes sense to use the point prevalence method.
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- 2022
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69. The impact of oocyte denudation without a pre-incubation on intracytoplasmic sperm injection outcomes
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Zehra Beyza Düzgün, Mehmet Cıncık, Yaprak Dönmez Çakıl, Şenay Kanaat, and Belgin Selam
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icsi ,multinucleation ,denudation ,embryo quality ,fertilization ,pregnancy ,Medicine - Abstract
Aims:Debate over the optimal timing of oocyte denudation following oocyte retrieval continues. Multinucleation has been associated with lower embryo quality and implantation rate. Defining oocyte characteristics might increase the chances of better embryo selection. This study aimed to investigate the laboratory and clinical outcomes of intracytoplasmic sperm injection when the oocytes were denuded immediately after oocyte retrieval.Methods:A prospective randomized sibling-oocyte study was performed. The participants were under 40 years of age with more than 5 oocytes. Patients with male factors were excluded. The study and control groups were formed by simple randomization. The study group underwent oocyte denudation immediately. In the control group, oocytes were routinely incubated in an equilibration solution for 2 h until the removal of the cumulus cells. Outcome measures were normal fertilization (two pronuclei, 2PN), multinucleation rate, the proportion of good quality embryos, blastocyst formation, and pregnancy rate.Results:A total of 792 oocytes were collected from 54 participants (mean age: 30.6±3.7 years). The fertilization rate was higher in the study group (n=209 in 376) compared with the controls (n=201 in 416) (55.6% vs. 48.3%, p=0.041). The multinucleation rate (6.6% vs. 4.3%, p=0.150), proportion of grade 1 embryos on day 3 (48.7% vs. 43%, p=0.112) and day 5 (27.7% vs. 23.8%, p=0.214), the proportion of embryos reaching blastocyst stage (34.0% vs. 28.1%, p=0.072), and the pregnancy rates (78.6% vs. 71.4%, p=1.000) were similar.Conclusions:Our results demonstrated that immediate removal of cumulus cells does not have any negative impact on intracytoplasmic sperm injection outcomes.
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- 2022
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70. Growth hormone status predicts left ventricular mass in patients after cure of acromegaly
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Michael H. Picard, Anne Klibanski, Lindsay Gunnell, Tamara Wexler, Zehra B. Omer, Pouneh K. Fazeli, Ronen Durst, Karen K. Miller, and David McCarty
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Heart Ventricles ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Population ,Cardiomyopathy ,Context (language use) ,Article ,Growth hormone deficiency ,Left ventricular mass ,Young Adult ,Endocrinology ,Internal medicine ,Acromegaly ,medicine ,Humans ,In patient ,Insulin-Like Growth Factor I ,education ,Aged ,education.field_of_study ,Human Growth Hormone ,business.industry ,Stroke Volume ,Organ Size ,Middle Aged ,medicine.disease ,Radiation therapy ,Cross-Sectional Studies ,Echocardiography ,Cardiology ,Female ,Hypertrophy, Left Ventricular ,business - Abstract
Growth hormone excess and growth hormone deficiency (GHD) are both associated with increased cardiovascular morbidity. A specific acromegaly-related cardiomyopathy has been described, characterized in part by increased left ventricular mass (LVM). Growth hormone deficiency is associated with reduced LVM. Following cure of acromegaly with surgery or radiation therapy, GHD may develop; however, its effects on cardiac morphology and function in this population are not established.We hypothesized that the development of GHD in patients with prior acromegaly would be associated with cardiac morphologic and functional changes that differ from those in patients who are GH sufficient following cure of acromegaly.A cross-sectional study was conducted in a Clinical Research Center. Study participants consisted of three groups of subjects (n=34): I. Cured acromegaly with GHD (n=15), II. Cured acromegaly with GH sufficiency (n=8), and III. Active acromegaly (n=11). Main outcome measures included cardiac morphology and function, using echocardiography parameters.Mean age and BMI, 44.6 ± 2.3 years (SEM) and 30.7 ± 1.3 kg/m², respectively, were not different among the three groups. Mean peak GH values were: I. 2.8 ± 0.4 ng/ml; II. 30.1 ± 9.1 ng/ml (p=0.0002.) In group I, left ventricular mass, indexed to body surface area (LVMi), was within the normal range in all patients; moreover, left ventricular (LV) geometry was normal. At least 50% of patients in groups II and III had elevated LVMi, and in 50% of patients, LV geometry was abnormal, indicating pathologic hypertrophy. Ejection fraction was similar between all three groups. There were no significant differences in diastolic function.Patients who develop GHD following cure of acromegaly do not demonstrate elevated LV mass, in contrast to patients with a history of acromegaly but normal GH levels or to patients with active acromegaly. This suggests that GH status after treatment of acromegaly correlates with LV mass, and that, in GH sufficient patients, reversal of remodeling may be slower than previously thought. These data suggest that it will be important to determine whether GH replacement alters left ventricular morphology over time.
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- 2010
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71. Growth Hormone Deficiency Is Associated with Decreased Quality of Life in Patients with Prior Acromegaly
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Brooke Swearingen, Andrea L. Utz, Lisa B. Nachtigall, Tamara Wexler, Karen Kuhlthau, Catherine Beauregard, Karen K. Miller, Gwenda J. Graham, Zehra B. Omer, Beverly M. K. Biller, Anne Klibanski, Lindsay Gunnell, and Jay S. Loeffler
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Adult ,Male ,medicine.medical_specialty ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,Emotions ,Clinical Biochemistry ,Context (language use) ,Biochemistry ,Growth hormone deficiency ,Endocrinology ,Quality of life ,Surveys and Questionnaires ,Internal medicine ,Acromegaly ,medicine ,Humans ,Insulin-Like Growth Factor I ,Growth Disorders ,Depression (differential diagnoses) ,Human Growth Hormone ,business.industry ,Mental Disorders ,Biochemistry (medical) ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,Clinical research ,Quality of Life ,Anxiety ,Original Article ,Female ,medicine.symptom ,business - Abstract
Context: Both GH deficiency (GHD) and GH excess are associated with a decreased quality of life. However, it is unknown whether patients with GHD after treatment for acromegaly have a poorer quality of life than those with normal GH levels after cure of acromegaly. Objective: The aim of the study was to determine whether patients with GHD and prior acromegaly have a poorer quality of life than those with GH sufficiency after cure of acromegaly. Design and Setting: We conducted a cross-sectional study in a General Clinical Research Center. Study Participants: Forty-five patients with prior acromegaly participated: 26 with GHD and 19 with GH sufficiency. Intervention: There were no interventions. Main Outcome Measures: We evaluated quality of life, as measured by 1) the Quality of Life Adult Growth Hormone Deficiency Assessment (QoL-AGHDA); 2) the Short-Form Health Survey (SF-36); and 3) the Symptom Questionnaire. Results: Mean scores on all subscales of all questionnaires, except for the anger/hostility and anxiety subscales of the Symptom Questionnaire, showed significantly impaired quality of life in the GH-deficient group compared with the GH-sufficient group. Peak GH levels after GHRH-arginine stimulation levels were inversely associated with QoL-AGHDA scale scores (R = −0.53; P = 0.0005) and the Symptom Questionnaire Depression subscale scores (R = −0.35; P = 0.031) and positively associated with most SF-36 subscale scores. Conclusions: Our data are the first to demonstrate a reduced quality of life in patients who develop GHD after cure of acromegaly compared to those who are GH sufficient. Further studies are warranted to determine whether GH replacement would improve quality of life for patients with GHD after cure from acromegaly.
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- 2009
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72. Experimentally approved generalized model for circuit applications
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Bilgehan, Bülent, primary, Özyapıcı, Ali, additional, and Sensoy, Zehra B., additional
- Published
- 2017
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73. Tomographic Evaluation of Paranasal Sinus findings in COVID-19-Positive Patients
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Şeyda Akbal Çufalı, Ali Rıza Yağmur, Zehra Betül Paksoy, Mehmet Fatih Çakmak, Kürşat Murat Özcan, and Adalet Aypak
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Immunologic diseases. Allergy ,RC581-607 - Published
- 2022
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74. Development of the 0-6 Years Old Psychosocial Development Attitudes Scale and the First Application of the Scale Through Educational Intervention
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Ayşegül DÖNMEZ, Esra ENGİN, Gülseren KESKİN, Zehra BAYKAL AKMEŞE, and Tuğba DURMUŞ
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Nursing ,RT1-120 - Published
- 2022
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75. Estimation of (Co) Variance Components and Genetic Parameters for Pre- and Post-Weaning Growth Traits in Dağlıç Sheep
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Serdar Koçak, Samet Çinkaya, Mustafa Tekerli, Mustafa Demirtaş, Zehra Bozkurt, Koray Çelikeloğlu, Özlem Hacan, and Metin Erdoğan
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heritability ,maternal effect ,animal models ,growth traits ,Dağlıç sheep ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
The goal of this study was to estimate (co) variance components and genetic parameters for pre- and post-weaning growth traits in Dağlıç sheep, considering the direct additive genetic, maternal genetic, and maternal permanent environmental effects, with different statistical models. The information of 21,735 native Dağlıç lambs born between 2011 and 2021 was used to estimate (co) variance components by the Average Information-Restricted Maximum Likelihood algorithm. The results showed that the most suitable model was Model 3 for birth weight (BW), average daily gain (ADG), and weaning weight (WW). Model 4 was the most appropriate for weight at three (W3), weight at six (W6), and weight at twelve months of age (W12). The direct heritabilities for BW, W3, ADG, WW, W6, and W12 were 0.35 ± 0.02, 0.36 ± 0.03, 0.27 ± 0.02, 0.22 ± 0.02, 0.47 ± 0.05, and 0.47 ± 0.05, respectively. Genetic and phenotypic correlations amongst the traits were in the range of 0.103 ± 0.008 to 0.995 ± 0.002. These results can be used for the improvement of growth traits in the Dağlıç breed of sheep through selection.
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- 2023
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76. Prehabilitation Before Lumpectomy Can Prevent Loss of Range of Motion
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Omer, Zehra B. and Baima, Jennifer
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musculoskeletal diseases - Abstract
Case Diagnosis: On intake exam, patient reported twenty year history of shoulder pain and history of bilateral subacromial bursitis . On the day of the exam, she rated her left shoulder pain (ipsilateral to breast cancer) at 2/10. Physical exam showed tenderness over left subacromial bursa, pain with resisted shoulder abduction and external rotation and ROM limited 120 degrees or less bilaterally. Case Description: Here, we report the case of a 73 year old woman with a 20 year history of bilateral subacromial bursitis and left shoulder pain who began an independent daily shoulder exercise regimen as instructed by a physiatrist 2.5 weeks prior to left sided lumpectomy for breast cancer, and continued the exercises following the operation. One month post-surgery, physical exam revealed no loss in range of motion (ROM) in flexion and abduction of the left and right shoulders. Patient reported intermittent pain, manageable with NSAIDs, which started only after tamoxifen use. Discussion: Decline in physical functioning such as loss of ROM, decreased strength, and pain following surgery for breast cancer is a well-documented phenomenon associated with difficulties in performing activities of daily living (ADL). Studies have shown that rehabilitation interventions during treatment period following breast cancer surgery result in improvements in shoulder and arm function; however, no study to date investigated the effectiveness of interventions initiated before surgery (prehabilitation) for breast cancer. Conclusions: A daily exercise regimen prior to and following lumpectomy for breast cancer may prevent the development of shoulder dysfunction that is often reported in the cancer treatment period.
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- 2015
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77. Risk factors and lethality associated with Candidemia in severe COVID-19 patients
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Zehra Beştepe Dursun, Hilal Sipahioğlu, Recep Civan Yüksel, Hafize Sav, and Ilhami Çelik
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covid-19 ,candidemia ,intensive care unit ,risk factor ,Internal medicine ,RC31-1245 ,Biology (General) ,QH301-705.5 - Abstract
Background and Purpose: Candidemia remained important in the intensive care units(ICU) during the COVID-19 pandemic. This study aimed to investigate the clinical and laboratory data on candidemia in COVID-19 patients.Materials and Methods: The baseline characteristics, as well as laboratory and clinicalfindings of candidemia and non-candidemia patients, were compared. Candidemia was defined as the isolation of Candida spp. from blood cultures. The isolates were identified by VITEK® 2 (bioMérieux, France) commercial method. Antifungal susceptibility was assessed using the E-test method. Univariate and multiple binary logistic regression analyses were performed to compare the variables.Results: In total, 126 patients with the COVID-19 disease were included. Candidemiawas diagnosed in 44 (35%) of the patients. The number of patients with diabetes mellitus and chronic renal failure was higher in the candidemia group. In the candidemia group, the duration of ICU stay of patients, the 30-day mortality rate, mechanical ventilation therapy, and systemic corticosteroids (Prednisone) usage were significantly higher in candidemia patients. Moreover, the median white blood cell, neutrophils, and lactate dehydrogenase were higher in the candidemia group. Univariate and multiple binary logistic regression analyses were performed to compare the variables. Isolated species were identified as Candida albicans (n=12, 41%), Candida parapsilosis (n=7, 24%), Candida glabrata (n=6, 21%), Candida tropicalis (n=3, 10%), and Candida dublinensis (n=1, 3%). In total, three isolates of six C. glabrata species had dose-dependent sensitivity to fluconazole, and one C. parapsilosis was determined to be resistant.Conclusion: The COVID-19 patients who are admitted to ICU have many risk factors associated with candidemia. The most common risk factors for the development of candidemia were mechanical ventilation, diabetes mellitus, neutrophilia, and low hemoglobin level. The most frequently isolated species was C. albicans. Moreover, caspofungin was found to be the most effective drug in vitro. No significant resistancepattern was detected against the isolated species. It should be noted that risk-stratified antifungal prophylaxis in the ICU is possible.
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- 2022
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78. Determination of PCB Levels Indoor and Outdoor Dust Samples of Primary Schools in Düzce
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Aslı TEKLİ, Seda Aslan Kılavuz, and Zehra Bozkurt
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düzce ,dust ,pcb ,pollution distribution maps ,Disasters and engineering ,TA495 ,Environmental sciences ,GE1-350 - Abstract
Düzce province, where industry, traffic and residential areas are intertwined, is developing rapidly and therefore environmental pollution is intensely felt in the region. Air pollutants from emission sources cannot be dispersed due to the geographical location of the province and pose important health risks. In this study, dust samples were collected at different locations in order to explain the regional pollution distribution and various emission sources. Because children are more sensitive to air pollutants, indoor and outdoor environments of primary schools were selected for sampling. PCB levels were determined in dust samples collected from indoor and outdoor environments of the primary schools in Düzce. PCB analyses were performed by using the Gas chromatograph/Mass Spectrometer (GC/MS) instrument. In the obtained results, outdoor ΣPCB concentrations were between 0.737 and 22.307 ng/gr, with an average of 3,626 ng/gr. Indoor ΣPCB concentrations were between 17.17 and 294.22 ng/gr, with an average of 66.89 ng/gr. High ∑PCB concentrations in indoor samples show that the contribution of indoor sources and the effect of accumulation in indoor environments by transport from the outdoor environments is greater. In the evaluation made according to outdoor sources, the highest concentrations were obtained mostly at points close to the industrial area. The lowest concentrations were measured at rural sampling points.
- Published
- 2022
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79. Literacy Level of the Parents Having Children in the Pre-School Period: A Mixed Method Study
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Zehra Bilgen, Hatice Berna Türe Köse, Ensar Yıldız, and Mübeccel Gönen
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early literacy ,family literacy ,child literacy ,erken okuryazarlık ,aile okuryazarlığı ,çocuk okuryazarlığı ,Education - Abstract
Bu çalışmanın amacı, okul öncesi dönem çocuğu olan ebeveynlerin okuryazarlık durumlarını anne baba okuryazarlığı, çocuk okuryazarlığı ve erken okuryazarlık alt boyutlarında incelemektir. Çalışmada karma yöntem türlerinden açımlayıcı sıralı desen kullanılmıştır. Çalışmanın örnekleminde, amaçlı örnekleme türlerinden ölçüt örnekleme kullanılmıştır. Nicel verilerin toplanması için “Aile Okuryazarlık Ölçeği” kullanılarak, 243 ebeveyne uygulanmıştır. Doğrulayıcı faktör analizi yapmak için SmartPLS programı kullanılmış ve kısmi en küçük kareler yol analizi yapılmıştır. “Aile Okuryazarlık Ölçeği” ile toplanan verilerin analizinde Kruskal Wallis H ve Mann Whitney U testleri kullanılmıştır. Çalışmanın nitel boyutunda, nicel boyutuna katılmış ve gönüllü olan 15 ebeveyn ile yapılan görüşmelere MAXQDA Analytics Pro 2018 (18. 2. 5) programıyla içerik analizi yapılmıştır. Ebeveynlerin yaşlarının, kitap okuma sıklığının, okuryazarlık düzeylerini etkilediği görülmüştür. Resimli öykü kitabı okuma sürecinde parmak takibi yapma, noktalama işaretlerine, büyük küçük harfe dikkat çekme gibi unsurların yapılmadığı, sebebininse çocukların yaşlarının küçük olması ya da okuma yazma öğretimine girmesi nedeniyle yapmak istememeleri olduğu belirlenmiştir.
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- 2022
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80. Feasibility and Safety of a Home Exercise Program for Patients With High Grade Brain Tumors
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Baima, Jennifer, primary, Omer, Zehra B., additional, Varlotto, John, additional, and Yunus, Shakeeb, additional
- Published
- 2016
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81. Investigation of Scavenger Receptor Class B Type I gene variants in patients with coronary heart disease with a history of early myocardial infarction
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Burcu Çaykara, Bengü Tokat, Ender Coşkunpınar, Özlem Küçükhüseyin, Deniz Kanca Demirci, Zehra Buğra, Gülçin Özkara, Oğuz Öztürk, Sadrettin Pençe, and Hülya Yılmaz Aydoğan
- Subjects
Medicine ,Internal medicine ,RC31-1245 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2021
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82. Role of global longitudinal strain in discriminating variant forms of left ventricular hypertrophy and predicting mortality
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Pelin Karaca Özer, Elif Ayduk Gövdeli, Berat Engin, Adem Atıcı, Derya Baykız, Hüseyin Orta, Zeynep Gizem Demirtakan, Samim Emet, Ali Elitok, Yelda Tayyareci, Berrin Umman, Ahmet Kaya Bilge, and Zehra Buğra
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2021
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83. Examination of student opinions on the use of the my mind notes application created using QR code technology in nursing education in clinical practice
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Zehra Belhan, Emine Tuğba Yorulmaz, Vildan Kocatepe, Yasemin Uslu, Nermin Ocaktan, Elif Ezgi Karatepe, and Vesile Unver
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Quick response codes ,Technology ,Nursing education ,History of Africa ,DT1-3415 ,Nursing ,RT1-120 - Abstract
Aim: The aim of this study is to examine the effectiveness of using the “My Mind Notes” application, which was developed to utilize QR code technology, in undergraduate nursing clinical education. Method: This design-based research was conducted with medical-surgical nursing students from a university located in Istanbul (n = 78) between February and July 2021. The information that the student would need in clinical practice was included in the educational material of the QR code. QR codes were utilized throughout the 10-day clinical practice, and students’ views were obtained at the end of the practice. The data were collected using the “Student Views on the Effectiveness of My Mind Notes Application” form, which was prepared to align with the literature and expert opinion. The data were analyzed using descriptive statistical methods such as number, percentage, and mean. Results: In their education lives, 78.2 % of the students had never used a QR code application. The students’ mean scores of psycho-motor skills, cognitive/theoretical information, and anxiety reduction in clinical practice concerning the My Mind Notes application were 7.76 ± 1.74, 8.34 ± 1.71, and 6.46 ± 2.36, respectively. Conclusion: It is shown that the “My Mind Notes” application prepared using QR code technology helps nursing students become lifelong learners by enriching their learning experiences regardless of time and place.
- Published
- 2023
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84. Impact of ductal carcinoma in situ terminology on patient treatment preferences
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E. Shelley Hwang, Elissa M. Ozanne, Zehra B. Omer, Laura J. Esserman, and Rebecca Howe
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medicine.medical_specialty ,business.industry ,General surgery ,Breast Neoplasms ,Patient Preference ,Ductal carcinoma ,Terminology ,Carcinoma, Intraductal, Noninfiltrating ,Terminology as Topic ,Internal Medicine ,medicine ,Humans ,Patient treatment ,Female ,business - Published
- 2013
85. Ortadoğu ve Batı Medyasında 15 Temmuz Darbe Girişimi İle Mısır Darbesi Mukayesesi.
- Author
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GÜNEY, Zehra B.
- Abstract
Copyright of Asia Minor Studies is the property of Asia Minor Studies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
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86. Experimentally approved generalized model for circuit applications.
- Author
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Bilgehan, Bülent, Özyapıcı, Ali, and Sensoy, Zehra B.
- Subjects
ELECTRIC circuits ,LEAST squares ,APPROXIMATION theory ,SYSTEM analysis ,EXPONENTIAL functions - Abstract
Summary: In this paper, generalized model based on the multiplicative least square method presented and showed that it is convenient to approximate observation in the electrical system analysis. The introduced model is exponential based and relies on parametric values. The advantage of the method is due to exponential derivation process within multiplicative calculus and has the flexibility to represent widely used functions such as Gaussian and exponentials. In spite of numerous results on the best fitting model, we study the robustness of the method by making direct comparisons with Matlab built‐in functions. The presented model is challenging because modern electrical circuits and systems are faced with different types of inputs that require near exact representation for accurate processing. Some real applications of exponential‐based data were selected to demonstrate the applicability and efficiency of the proposed representation. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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87. SLAUGHTER AND CARCASS TRAITS OF NATIVE GEESE REARED IN MUŞ PROVINCE
- Author
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BETÜL ÇELİK and ZEHRA BOZKURT
- Subjects
goose ,sex ,slaughter traits ,carcass traits ,Agriculture ,Technology ,Science - Abstract
This study was conducted to determine the slaughter and carcass traits and the effects of sex on these traits of native geese reared in Muş. A total of 41 geese (17 male and 24 female) which were 8-10 months of age were used. The means of slaughter weight, cold carcass weight, head weight, feet weight, heart weight, liver weight, gizzard weight and spleen weight were 3968.6, 2678.7, 172.1, 131.4, 38.6, 69.3, 144.3, 2.28 g for males, and 3212.2, 2047.6, 138.5, 113.0, 24.8, 76.3, 142.2, 2.18 g for females respectively. Significant phenotypic correlation coefficients were calculated between slaughter weight and feather, head and feet weights in both sex groups and between carcass weight and feather and feet weight in only male geese. Slaughter weight was positively related with heart and gizzard weights in males, carcass weight was negatively related with liver weight in females (r= -0.45). In conclusion, the results of obtained in this study indicated that meat yield was low of the geese reared extensively in Muş province, the slaughter and carcass trait and the phenotypic correlations among of this traits were affected by sex.
- Published
- 2023
88. FARM ANIMAL WELFARE LEGAL REQUIREMENTS AND TRADITIONAL PRACTICES: A CASE STUDY OF WELANIMAL PARTNER COUNTRIES
- Author
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ZEHRA BOZKURT, EVANGELIA N. SOSSIDOU, L. T. CZISZTER, MARYA PENEVA, SZ. KONRÁD, J. VENGLOVSKY, and E. SZÜCS
- Subjects
animal welfare ,central and south-eastern europe ,welanimal project ,Agriculture ,Technology ,Science - Abstract
According to the Amsterdam Treaty, animals are sentient creatures and animal welfare requirements should be precisely met while preparing and implementing the Commission laws. Accomplishing this, cultural, religious and regional characteristics should be considered. However, more and more regulations and laws are continuously introduced in Europe and worldwide. Ongoing WELANIMAL Project was financed by EU Commission adapting of vocational training products and results of training tools of WELFOOD related to the animal welfareenvironment-food quality interactions is being enriched with consideration of cultural, socio-economic and religious approaches in order to determine a common work definition for all sectorial workers having different moral and social values on the subject of animal welfare and food safety Central and South-eastern Europe region. Although there is slight differences, national legislation in partner countries of EU in Project were harmonious with legal framework in EU regarding for all farm species. It is expected that three draft regulations in compliance with legal requirements animal protection in farms and during transportation and slaughtering and killing in Turkey, as a candidate country to membership into EU, in 2009. Also, due to in participating countries to the Project have ethnicity, history, tradition and religious structure show a great diversity it has been guessed that welfare concept which is a moral issue can be effected by people’s cultural, religious and social composition. In the WELANIMAL Project, the effects of socio-cultural, religious and regional historical differences of workers and consumers within animal production chain on understanding of animal welfare concepts are being analysed. Furthermore in the light of obtained data a common vocational animal welfare definition and animal welfare, food quality and environment interaction will be evaluated. Through the Project web page (www.welanimal.aku.edu.tr) interactive training and certification will be accomplished. This paper intents to provide an overview of legal framework including Council Directives and National legislation laying down minimum welfare standards and traditional practices in Central and Sought eastern Europe in which WELANIMAL Project is ongoing.
- Published
- 2023
89. EFFECTS OF HEN AGE, STORAGE PERIOD AND STRETCH FILM PACKAGING ON INTERNAL AND EXTERNAL QUALITY TRAITS OF TABLE EGGS
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AHMET ALPER YILMAZ and ZEHRA BOZKURT
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table egg ,hen age ,storage time ,stretch film ,quality ,Agriculture ,Technology ,Science - Abstract
The effects of hen age, storage time and packaging with stretch film applications to the internal and external egg quality of table eggs were investigated. A total of 1680 table eggs were used and collected with two commercial layer stocks (Lohmann White ) 28 and 80 weeks old age. A half of the table eggs packaged with stretch film and all eggs were stored 0, 15, 30 and 45 days at 22 ºC ve 45 % RH . Egg weight, shape index, albumen index, fracture strength, albumen index, yolk index Hauhg unit, yolk color, shell weight, shell thickness, shell weight per unit surface of shell and shell density were examined in the study. Egg weight, egg weight loss, shell weight, albumen index, yolk index, Haugh unit, shape index, shell strength, shell thickness, shell density values were found as higher in the young hen flocks’ eggs. Egg weight loss, shell strength, shell thickness, egg weight, shell density increased and egg weight, albumen index, yolk index and Haugh Units and shell weigh decreased as storage time increased. Packaging eggs with stretch film reduced the internal quality losses resulted from prolonged storage.
- Published
- 2023
90. Study on Romanian Consumers’ Opinion Regarding the Animal Welfare Labelling of Animal Products
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Ludovic Toma Cziszter, Mariya Peneva, Endre Szücs, Zehra Bozkurt, Stelian Acatincăi, Evangelia N. Sossidou, Dinu Gavojdian, and Mishev Plamen
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animal products ,animal welfare ,labels ,romanian consumers ,Agriculture ,Technology ,Science - Abstract
The aim of the paper was to investigate the influence some factors on the consumers’ opinion regarding the animal welfare labelling of animal products. The analysed question was: “When purchasing eggs, meat or milk can you easily identify from the label those products sourced from animal welfare friendly production systems?” Respondents chosen only one answer out of the five offered: yes, most of the time; yes, some of the time; no, very rarely; no, never; and don’t know. Thirty three percent of females considered they could find sometime information regarding the animal welfare on the labels, while males considered that this information could be found very rarely. Up to 55 years of age, 50% of the consumers consider that the labels do not contain the information about animal welfare, while after this age most of consumers consider they found this information on the labels. Over 50% of Orthodox and Roman Catholic responders considered that the information on animal welfare on the labels was found some of the time or very rarely. Respondents, irrespective of their living area or monthly income, considered that there is scarce information regarding animal welfare on the labels. Internet access significantly influenced the consumers regarding the availability of the information on the labels.
- Published
- 2023
91. Feasibility and Safety of a Home Exercise Program for Patients With High Grade Brain Tumors
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John M. Varlotto, Jennifer Baima, Shakeeb Yunus, and Zehra B. Omer
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03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,Physical medicine and rehabilitation ,business.industry ,030220 oncology & carcinogenesis ,Home exercise program ,Rehabilitation ,Physical therapy ,Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,business ,030215 immunology - Published
- 2016
- Full Text
- View/download PDF
92. Elif Baga. Hesab Biliminde Kılavuz: eş-Şemsiyye fi’l-Hisâb (Nizâmeddin en-Nîsâbûrî), İnceleme-Çeviri-Eleştirmeli Metin
- Author
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Zehra Bilgin
- Subjects
Islam ,BP1-253 - Published
- 2021
- Full Text
- View/download PDF
93. Does the Presence and Absence of Queen Bee in the Production of Royal Jelly Affect the Amount of Soluble Protein and Ratio of 10-Hydroxy-2-Decenoic Acid?
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Aytül Uçak Koç, Mete Karacaoğlu, Zehra Burcu Bakır, and Burcu Keser
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honey bee ,starter-finisher colony ,queenless colony ,royal jelly yield ,soluble protein ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Royal jelly (RJ), is one of the important honey bee products and a functional food item in the regulation of diets and in the cosmetic industry. RJ has a potential towards various human disease treatments. The chemical content of RJ is influenced by some factors. In this study, the effect of the presence or absence of the queen on the amount of 10-hydroxy-2-decenoic acid (10-HDA) and soluble protein in RJ is determined. For this reason, colonies were prepared as queenless, queenright and starter-finisher. RJ yields in colonies queenless, queenright and starter-finisher were determined as 15.2 ± 0.89 g, 12.0 ± 0.90 g and 9.6 ± 0.72 g, respectively. Group queenless was different from the other two groups. While 10-HDA values of the groups were similar (queenless, queenright and starter-finisher, respectively; 2.0 ± 0.06%, 2.1 ± 0.06% and 2.0 ± 0.05%), the soluble protein amounts of the groups (queenless, queenright and starter-finisher, respectively, 9.65 ± 0.179%, 7.68 ± 0.184%, 7.50 ± 0.203%) were found different and significant from each other. As a result, the RJ production colony queenless or queenright affected the amount of soluble protein. The worker bees of queenless colonies secreted RJ containing more soluble protein.
- Published
- 2021
- Full Text
- View/download PDF
94. Increasing of Phenolic Compounds by Brassinosteroid Applications in Immobilized Cell Suspension Cultures of Vitis vinifera L. cv. Cinsault
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Zehra Babalik
- Subjects
24-ebl ,immobilization ,grapevine ,phenolic compounds ,Agriculture (General) ,S1-972 - Abstract
In this paper, the effects on secondary metabolite accumulation of brassinosteroid (BR) (24-epibrassinolide (24-eBL) on immobilized cells that were obtained from Vitis vinifera cv. Cinsault was investigated. 24-eBL was treated to immobilized cells covered calcium alginate beads at concentrations of 0, 0.25, 0.50, 0.75 and 1.0 mg L-1 for one month. As a result of this study, it was found that 24-eBL applications modified secondary metabolite accumulation and had positive effects on secondary metabolite production when the suitable concentration was used. While the highest total phenolic, catechin, p-coumaric acid and chlorogenic acid contents were found in immobilized cells treated 0.75 mg L-1 24-eBL, the highest epicatechin, quercetin, trans-resveratrol contents were obtained in immobilized cells treated 0.50 mg L-1 24-eBL and the highest gallic acid content was determined in immobilized cells treated 0.25 mg L-1 24-eBL. Moreover, the highest 24-eBL concentration (1 mg L-1) decreased the content of secondary metabolite compared to the control (0 mg L-1 24-eBL) except total phenolic and catechin content. To conclude, 0.50 and 0.75 mg L-1 24-eBL concentrations were the most suitable concentrations for immobilized cell culture to provide the highest secondary metabolite accumulation.
- Published
- 2021
- Full Text
- View/download PDF
95. Effective Root-Finding Methods for Nonlinear Equations Based on Multiplicative Calculi
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Özyapıcı, Ali, primary, Sensoy, Zehra B., additional, and Karanfiller, Tolgay, additional
- Published
- 2016
- Full Text
- View/download PDF
96. 3 Evaluation of the reliability and quality of the nutritional information in COVID-19 videos shared on YouTube
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Elif Inan-Eroglu and Zehra Buyuktuncer
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Nutritional diseases. Deficiency diseases ,RC620-627 - Published
- 2022
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97. The Radiological Evaluation of Mandibular Canal Related Variables in Mandibular Third Molar Region: a Retrospective Multicenter Study
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Dogukan Yilmaz, Emel Tuğba Ataman-Duruel, Zehra Beycioğlu, Samir Goyushov, Tansu Çimen, Onurcem Duruel, and Tolga Fikret Tözüm
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mandible ,radiology ,surgery ,tomography ,Dentistry ,RK1-715 - Abstract
Objectives: The aim of this retrospective study was to investigate anatomical structure of mandibular canal and the factors those increase the possibility of inferior alveolar nerve damage in mandibular third molar region of Turkish population. Material and Methods: Overall 320 participants with 436 mandibular third molars were included from four different study centers. Following variables were measured: type and depth of third molar impaction, position of mandibular canal in relation to third molars, morphology of mandibular canal, cortication status of mandibular canal, possible contact between the third molars and mandibular canal, thickness and density of superior, buccal, and lingual mandibular canal wall, bucco-lingual and apico-coronal mandibular canal diameters on cone-beam computed tomography scans. Results: Lingual mandibular canal wall density and thickness were decreased significantly as the impaction depth of mandibular third molar was increased (P = 0.045, P = 0.001 respectively). Highest buccal mandibular canal wall density and thickness were observed in lingual position of mandibular canal in relation to mandibular third molar (P = 0.021, P = 0.034 respectively). Mandibular canal with oval/round morphology had higher apico-coronal diameter in comparison to tear drop and dumbbell morphologies (P = 0.018). Additionally, mandibular canals with observed cortication border and no contact with mandibular third molar had denser and thicker lingual mandibular canal wall (P = 0.003, P = 0.001 respectively). Conclusions: Buccal and lingual mandibular canal wall density, thickness and mandibular canal diameter may be related with high-risk indicators of inferior alveolar nerve injury.
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- 2022
- Full Text
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98. Suûdi Arabistan ders kitaplarında türkler ve türk imajı
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Gökdemir, Zehra B., Özgüdenli, Osman G, and Ortadoğu Siyasi Tarihi ve Uluslararası İlişkiler Anabilim Dalı
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Eğitim ,Türkler ,Suûdi Arabistan ,Öğrenim ve Öğretim - Abstract
ÖZETBu çalışma, Türkler ve Türk imajı hakkında Suûdi Arabistan ders kitaplarında geçen bilgileri tespit ederek bir sonuca ulaşmayı hedeflemektedir. Aynı zamanda bu bilgiler, Türkiye Cumhuriyeti ders kitapları ve Mısır, Tunus, Suriye, Ürdün gibi diğer Arap ülkelerinin ders kitapları ile de karsılaştırılmıştır.Varılan sonuç, Memlûklar, Eyyûbîler, Zengîler, Selçuklular, Gazneliler, Tulûnogulları ve Osmanlılar’ın siyasî tarihlerinin Suûdi Arabistan ders kitaplarında müsbet yönde zikrediliyor olmasıdır. Bu devletlerin Arap edebiyatına olan katkıları ile Osmanlı Devleti, Suûdi Arabistan ders kitaplarında detaylı bir şekilde islenmektedir. Coğrafya dersinde ise, Türkiye Cumhuriyeti’nin ekonomisi, sanayisi ve coğrafî yapısı hakkında oldukça geniş bilgi verilmektedir. Türk imajının oldukça olumlu olduğu Suûdi Arabistan ders kitaplarını, Mısır, Ürdün, Suriye ve Tunus ders kitaplarıyla karsılaştırdığımızda, bu ülkelerin müfredâtında Osmanlı hariç Türk tarihinin hemen hemen hiç işlenmediği görülmektedir. Bu ülkelerin tarih ders kitaplarında islenen Türk imajının ise oldukça olumsuz olduğu sonucu ortaya çıkmaktadır.Anahtar KelimelerTürk-Arap İlişkileri, Tolûnogulları, Gazneliler, Eyyûbîler, Zengîler, Memlûklar, Selçuklular, Haçlı Seferleri, Mogollar, Osmanlı Devleti, II. Abdülhamid, Salâh el-dîn Eyyûbî, Vahhabîlik, İttihad ve Terakkî Cemiyeti, Türkçülük, Turancılık, Atatürk, Laiklik, Türkiye.ABSTRACTThis thesis is trying to reach a conclusion by studying the information about the Turks and the image of Turks in Saudi Arabia’s school books. At the same time these information is compared with the school books in Turkey and other Arabic countries like Egypt, Tunis, Syria and Jordan.The conclusion is; mentioning of Mamluks, Ayyubids, Zangids, Saldjukids, Ghaznawids, Tulunids, and Ottomans in Saudi Arabian school books is very positive. Contributions of these countries to Arabic literature and every period of Ottomans are studied in details in Saudi Arabian school books. In geography classes Turkey’s economy, industry and geographical structure are studied in depth.When we compare the positive Turkish image in Saudi Arabian school books with the school books of Egypt, Jordan, Syria and Tunis, we find these other books mentioning only the history of Ottomans and not the history of new Turkey. Turkish image that is presented in the Ottoman history textbooks of these countries is reflected very negatively.KeywordsTurkish-Arab Relations, Tulunids, Ghaznawids, Ayyubids, Zangids, Mamluks, Saldjukids, Crusades, Mongols, Ottoman Empire, Abd al-Hamid II, Salah al-Din Ayyubi, Wahhabiyya, The Committee of Union and Progress, Turkism, Turanism, Atatürk, Secularism, Türkiye.
- Published
- 2010
99. Does serum butyrylcholinesterase level determine the severity and mortality of COVID-19 pneumonia?: Prospective study
- Author
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Hilal Sipahioglu, Aliye Esmaoglu, Ayse Kiris, Zehra Bestepe Dursun, Sibel Kuzuguden, Mine Altinkaya Cavus, and Cem Artan
- Subjects
COVID-19 ,pneumonia ,butyrylcholinesterase ,marker ,mortality ,Medicine (General) ,R5-920 - Abstract
BackgroundThe WHO emphasized the importance of knowing the risk factors for the severity of the disease in the COVID-19 pandemic. Our aim in this study was to determine the relationship between serum Butyrylcholinesterase (BChE) level, which is rapidly affected by inflammation, and the severity of COVID-19 pneumonia and mortality.MethodsPatients diagnosed with COVID-19 pneumonia between March and May 2021 were included in the study. The patients were divided into two groups as severe and mild to moderate pneumonia according to the WHO's guidelines. Serum BChE levels were studied by ELISA method from the blood samples taken from the patients on the day of hospitalization. The severity of the disease and other factors affecting hospital mortality were also evaluated.Results147 patients with COVID-19 pneumonia were included in this study. Of these patients, 58% had severe pneumonia and 42% had mild to moderate pneumonia. The BChE level was median 13 (IQR: 11.2–21.5)ng/ml in patients with severe COVID-19 pneumonia and median 20 (IQR: 10–35.7)ng/ml in patients with mild to moderate pneumonia (p: 0.001). Hospital with mortality rate was higher in patients with low BChE levels. However, statistically, BChE hasn't associated mortality in COVID-19 pneumonia [OR 1.002 (0.957–1.049) p: 0.490]. CRP, procalcitonin, lactate, and D-dimer levels were associated mortality in COVID-19 pneumonia.ConclusionBeing not statistically significant, the mortality rate was higher in patients with low BChE levels. BChE level is an important marker in determining the severity of COVID-19 pneumonia. Early prediction of the severity of COVID-19 pneumonia will enable early planning of the treatment process.
- Published
- 2022
- Full Text
- View/download PDF
100. Personalized Medicine Through SNP Testing for Breast Cancer Risk: Clinical Implementation
- Author
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Howe, Rebecca, primary, Miron-Shatz, Talya, additional, Hanoch, Yaniv, additional, Omer, Zehra B., additional, O’Donoghue, Cristina, additional, and Ozanne, Elissa M., additional
- Published
- 2014
- Full Text
- View/download PDF
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