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503 results on '"Zauscher, Stefan"'

59. Bionanomanufacturing

Author

Zauscher, Stefan, primary, Johannes, Matthew, additional, Chow, Dominic, additional, Lee, Woo-Kyung, additional, Chilkoti, Ashutosh, additional, and Clark, Robert, additional

Published
2007
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83. Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer

Author

Yildiz,Tugba, Gu,Renpeng, Zauscher,Stefan, Betancourt,Tania, Yildiz,Tugba, Gu,Renpeng, Zauscher,Stefan, and Betancourt,Tania

Abstract

Tugba Yildiz,1 Renpeng Gu,2 Stefan Zauscher,2 Tania Betancourt1,3 1Materials Science, Engineering, and Commercialization Program, Texas State University, San Marcos, TX, 2Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 3Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA Introduction: Despite significant progress in the field of oncology, cancer remains one of the leading causes of death. Chemotherapy is one of the most common treatment options for cancer patients but is well known to result in off-target toxicity. Theranostic nanomedicines that integrate diagnostic and therapeutic functions within an all-in-one platform can increase tumor selectivity for more effective chemotherapy and aid in diagnosis and monitoring of therapeutic responses. Material and methods: In this work, theranostic nanoparticles were synthesized with commonly used biocompatible and biodegradable polymers and used as cancer contrast and therapeutic agents for optical imaging and treatment of breast cancer. These core–shell nanoparticles were prepared by nanoprecipitation of blends of the biodegradable and biocompatible amphiphilic copolymers poly(lactic-co-glycolic acid)-b-poly-L-lysine and poly(lactic acid)-b-poly(ethylene glycol). Poly-L-lysine in the first copolymer was covalently decorated with near-infrared fluorescent Alexa Fluor 750 molecules. Results: The spherical nanoparticles had an average size of 60–80 nm. The chemotherapeutic drug doxorubicin was encapsulated in the core of nanoparticles at a loading of 3% (w:w) and controllably released over a period of 30 days. A 33-fold increase in near-infrared fluorescence, mediated by protease-mediated cleavage of the Alexa Fluor 750-labeled poly-L-lysine on the surface of the nanoparticles, was observed upon interaction with the model protease trypsin. The cytocompatibility of drug-free nanoparticles and growth inhibition of drug-loaded nanopar

Published
2018

89. Macromol. Rapid Commun. 20/2017

Author

Li, Nan K., primary, Kuang, Huihui, additional, Fuss, William H., additional, Zauscher, Stefan, additional, Kokkoli, Efrosini, additional, and Yingling, Yaroslava G., additional

Published
2017
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96. Capture and release of proteins on the nanoscale by stimuli-responsive elastin-like polypeptide 'switches'

Author

Jinho Hyun, Woo-Kyung Lee, Nath, Nidhi, Chilkoti, Ashutosh, and Zauscher, Stefan

Subjects
Gold -- Structure, Nanotechnology -- Research, Polypeptides -- Structure, Chemistry
Abstract

The fabrication and characterization of stimulus-responsive elastin-like polypeptide (ELP) nanostructure grafted onto omega-substituted thiolates that were patterned onto gold surfaces by dip-pen nanolithography is described. Fabricating the switchable surfaces is attractive because it is entirely modular and generic, in that it only requires an ELP-modified or patterned surface and a protein that can be appended with an ELP tag.

Published
2004

97. Understanding and Mapping Sensitivity in MoS2Field-Effect-Transistor-Based Sensors

Author

Noyce, Steven G., Doherty, James L., Zauscher, Stefan, and Franklin, Aaron D.

Abstract

Sensors based on two-dimensional (2D) field-effect transistors (FETs) are extremely sensitive and can detect charged analytes with attomolar limits of detection (LOD). Despite some impressive LODs, the operating mechanisms and factors that determine the signal-to-noise ratio in 2D FET-based sensors remain poorly understood. These uncertainties, coupled with an expansive design space for sensor layout and analyte positioning, result in a field with many reported highlights but limited collective progress. Here, we provide insight into sensing mechanisms of 2D molybdenum disulfide (MoS2) FETs by realizing precise control over the position and charge of an analyte using a customized atomic force microscope (AFM), with the AFM tip acting as an analyte. The sensitivity of the MoS2FET channel is revealed to be nonuniform, manifesting sensitive hotspots with locations that are stable over time. When the charge of the analyte is varied, an asymmetry is observed in the device drain–current response, with analytes acting to turn the device off leading to a 2.5× increase in the signal-to-noise ratio (SNR). We developed a numerical model, applicable to all FET-based charge-detection sensors, that confirms our experimental observation and suggests an underlying mechanism. Further, extensive characterization of a set of different MoS2FETs under various analyte conditions, coupled with the numerical model, led to the identification of three distinct SNRs that peak with dependence on the layout and operating conditions used for a sensor. These findings reveal the important role of analyte position and coverage in determining the optimal operating bias conditions for maximal sensitivity in 2D FET-based sensors, which provides key insights for future sensor design and control.

Published
2020
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98. Ti3C2TxMXene-Reduced Graphene Oxide Composite Electrodes for Stretchable Supercapacitors

Author

Zhou, Yihao, Maleski, Kathleen, Anasori, Babak, Thostenson, James O., Pang, Yaokun, Feng, Yaying, Zeng, Kexin, Parker, Charles B., Zauscher, Stefan, Gogotsi, Yury, Glass, Jeffrey T., and Cao, Changyong

Abstract

The development of stretchable electronics requires the invention of compatible high-performance power sources, such as stretchable supercapacitors and batteries. In this work, two-dimensional (2D) titanium carbide (Ti3C2Tx) MXene is being explored for flexible and printed energy storage devices by fabrication of a robust, stretchable high-performance supercapacitor with reduced graphene oxide (RGO) to create a composite electrode. The Ti3C2Tx/RGO composite electrode combines the superior electrochemical and mechanical properties of Ti3C2Txand the mechanical robustness of RGO resulting from strong nanosheet interactions, larger nanoflake size, and mechanical flexibility. It is found that the Ti3C2Tx/RGO composite electrodes with 50 wt % RGO incorporated prove to mitigate cracks generated under large strains. The composite electrodes exhibit a large capacitance of 49 mF/cm2(∼490 F/cm3and ∼140 F/g) and good electrochemical and mechanical stability when subjected to cyclic uniaxial (300%) or biaxial (200% × 200%) strains. The as-assembled symmetric supercapacitor demonstrates a specific capacitance of 18.6 mF/cm2(∼90 F/cm3and ∼29 F/g) and a stretchability of up to 300%. The developed approach offers an alternative strategy to fabricate stretchable MXene-based energy storage devices and can be extended to other members of the large MXene family.

Published
2020
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