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52. OPTIMISING IVIG DELIVERY IN A TERTIARY NEUROLOGY CENTRE

Author

Zarkali, Angeliki, primary, Bonifacio, Guendalina, additional, Englezou, Christina, additional, Parsons, Victoria Van Hamel, additional, Renshaw, Hanna, additional, Ingle, Gordon, additional, Manji, Hadi, additional, Reilly, Mary, additional, Lunn, Michael, additional, and Carr, Aisling, additional

Published
2016
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53. OPTIMISING THE IVIG SERVICE: AN AUDIT OF MONITORING AND DOSAGE

Author

Sarr-Gonzales, Scherezade, primary, Zarkali, Angeliki, additional, Bonifacio, Guendalina, additional, Englezou, Christina, additional, Manji, Hadi, additional, Parton, Matt, additional, Hanna, Mike, additional, Lunn, Mike, additional, Reilly, Mary, additional, and Carr, Aisling, additional

Published
2016
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55. CD8+ encephalitis: a severe but treatable HIV-related acute encephalopathy.

Author

Zarkali, Angeliki, Gorgoraptis, Nikos, Miller, Robert, John, Laurence, Merve, Ashirwad, Thust, Stefanie, Jager, Rolf, Kullmann, Dimitri, and Swayne, Orlando

Abstract

Rapidly progressive encephalopathy in an HIVpositive patient presents a major diagnostic and management challenge. CD8+ encephalitis is a severe but treatable form of HIV-related acute encephalopathy, characterised by diffuse perivascular and intraparenchymal CD8+ lymphocytic infiltration. It can occur in patients who are apparently stable on antiretroviral treatment and probably results from viral escape into the central nervous system. Treatment, including high-dose corticosteroids, can give an excellent neurological outcome, even in people with severe encephalopathy and a very poor initial neurological status. We report a woman with CD8+ encephalitis, with a normal CD4 count and undetectable serum viral load, who made a good recovery despite the severity of her presentation. [ABSTRACT FROM AUTHOR]

Published
2017
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59. Frequency of the off-label use of monoclonal antibodies in clinical practice: a systematic review of the literature.

Author

Zarkali, Angeliki, Karageorgopoulos, Drosos E., Rafailidis, Petros I., and Falagas, Matthew E.

Subjects
*IMMUNOGLOBULINS, *ANTI-antibodies, *OFF-label use (Drugs), *CLINICAL medicine research, *RITUXIMAB, *BEVACIZUMAB
Abstract

The article discusses a systematic review on the frequency of the off-label use of monoclonal antibodies in clinical practice. It states the use of several anti-neoplastic monoclonal antibodies in the study including rituximab, bevacizumab and tositumomab. It also provides an overview of the systematic search of the literature and the clinical results of the conducted study.

Published
2014
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60. Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson’s disease

Author

Andrew J. Lees, Rimona S. Weil, Peter McColgan, Suzanne Reeves, Emmanuel Stamatakis, Angeliki Zarkali, Andrea I. Luppi, Leyland La, Zarkali, Angeliki [0000-0003-2808-072X], Luppi, Andrea I [0000-0002-3461-6431], Stamatakis, Emmanuel A [0000-0001-6955-9601], Apollo - University of Cambridge Repository, Stamatakis, Emmanuel [0000-0001-6955-9601], Lees, Andrew [0000-0002-2476-4385], and Weil, Rimona [0000-0002-5092-6325]

Subjects
692/617/375/1718, Parkinson's disease, Hallucinations, 5-HT2A receptor, 5202 Biological Psychology, Thalamus, Medicine (miscellaneous), Sensory system, Neurodegenerative, Biology, Serotonergic, General Biochemistry, Genetics and Molecular Biology, Visual processing, 631/378/1689/1718, medicine, 2.1 Biological and endogenous factors, Humans, Default mode network, 2 Aetiology, Brain Mapping, Parkinson's Disease, FOS: Clinical medicine, Dopaminergic, Neurosciences, article, Brain, Parkinson Disease, medicine.disease, Magnetic Resonance Imaging, Brain Disorders, 52 Psychology, Neurological, 59/57, 59/36, General Agricultural and Biological Sciences, 51 Physical Sciences, Neuroscience
Abstract

Funder: National Institute for Health Research (NIHR), Hallucinations are a core feature of psychosis and common in Parkinson's. Their transient, unexpected nature suggests a change in dynamic brain states, but underlying causes are unknown. Here, we examine temporal dynamics and underlying structural connectivity in Parkinson's-hallucinations using a combination of functional and structural MRI, network control theory, neurotransmitter density and genetic analyses. We show that Parkinson's-hallucinators spent more time in a predominantly Segregated functional state with fewer between-state transitions. The transition from integrated-to-segregated state had lower energy cost in Parkinson's-hallucinators; and was therefore potentially preferable. The regional energy needed for this transition was correlated with regional neurotransmitter density and gene expression for serotoninergic, GABAergic, noradrenergic and cholinergic, but not dopaminergic, receptors. We show how the combination of neurochemistry and brain structure jointly shape functional brain dynamics leading to hallucinations and highlight potential therapeutic targets by linking these changes to neurotransmitter systems involved in early sensory and complex visual processing.

Published
2021

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