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According to a great number of judgements by law courts the authors show different criterions for and against fixing a prison sentence and for and against suspension of punishment for probation in cases of drunken driving. The criterions depend partly on the way of committing an offence, partly on the person of the offender and partly even on his actions after the offence and before punishment. On principle an execution of punishment is necessary in cases of mortal drunken driving.

I kappa B is an inhibitory protein that stabilizes the inducible cytoplasmic form of the NF-kappa B transcription factor. We have purified I kappa B-alpha, a major form of I kappa B with an apparent molecular size of 37 kd, from cytosol of human placenta. A second chromatographically distinct form, I kappa B-beta, was partially purified and found to be more basic and 3-8 kd larger than the alpha form. The occurrence of distinct forms of I kappa B could explain how NF-kappa B can be activated in response to various agents that signal via different intracellular messenger systems. Both I kappa B-alpha and -beta exclusively inactivated NF-kappa B containing the non-DNA binding 65 kd subunit and, within minutes, could dissociate a high affinity complex of NF-kappa B with its cognate DNA. On the assumption that free I kappa B-alpha and -beta can enter the nucleus, these proteins could rapidly release NF-kappa B from high affinity binding sites in enhancer and promoter elements, thereby terminating NF-kappa B-dependent initiation of gene expression.