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1,035 results on '"ZHANG Hai-bo"'

60. A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth

Author

Hu, Qing-yong, Li, Lei, Li, Yu-huang, Zhang, Hai-bo, Deng, Tao, Liu, Yang, Li, Feng-tian, Xiao, Zhi-xiong, and Cao, Yang

Abstract

p53, a tumor suppressor protein, has a vital role in the regulation of the cell cycle, apoptosis, and DNA damage repair. The degradation of p53 is predominantly controlled by the murine double minute 2 (MDM2) protein, a ubiquitin E3 ligase. The overexpression or amplification of MDM2 is commonly observed in various human cancers bearing wild-type p53 alleles, leading to the rapid degradation of the p53 protein and the attenuation of p53 tumor suppression functions. Thus, a major effort in p53-based cancer therapy has been to research MDM2 antagonists that specifically stabilize and activate p53, leading to the suppression of tumor growth. However, despite numerous efforts to develop MDM2 antagonists, to date they have failed to reach clinical use, largely because of the cytotoxicity associated with these small molecules. This study used our newly designed structure-based virtual screening approach on a commercial compound library to identify a novel compound, CGMA-Q18, which directly binds to MDM2, leading to the activation of p53, the induction of apoptosis, and cell cycle arrest in cancer cells. Notably, CGMA-Q18 significantly inhibited tumor xenograft growth in nude mice without observable toxicity. These findings highlight our useful virtual screening protocol and CGMA-Q18 as a putative MDM2 antagonist.

Published
2024
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63. Application of Edmonton Symptom Assessment system in daily cancer pain management by acupuncture: Retrospective analysis of data from an inpatient oncology department and a pilot prospective study☆ 埃德蒙顿症状评估量表在针灸治疗癌痛患者中的应用:基于肿瘤科住院患者的回顾性分析和一项前瞻性预试验

Author

CHEN, Geng-hang, primary, FAN, Mei-yu, additional, CHANG, Xue-song, additional, WU, Ze-xia, additional, ZHANG, Hai-bo, additional, GUO, Xin-feng, additional, and HE, Yi-han, additional

Published
2023
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79. Retracted: Effect of Sham Acupuncture on Chronic Pain: A Bayesian Network Meta-Analysis.

Author

Zhou, Rui, Zhu, Yan-juan, Chen, Xian, Ma, Hao-chuan, Liu, Yi-hong, Chang, Xue-song, Chen, Ya-dong, Yu, Ya-ya, Xiao, Zhen-zhen, Liu, Li-rong, Li, Yong, and Zhang, Hai-bo

Abstract

Background Along with increasing research on acupuncture for chronic pain, the validity of sham acupuncture (SA) has also been argued. Methods Nine databases were searched for randomized controlled trials (RCTs) from the inception dates of the databases to July 5, 2022. With Markov Chain Monte Carlo methods, a Bayesian multiple-treatment network meta-analysis (NMA) with random-effects model was conducted. Results A total of 62 RCTs with 6,806 patients and four kinds of treatments (real acupuncture [RA], non-acupuncture [NA], penetrative SA [PSA], and non-penetrative SA [NPSA]) were included. The results indicated that both NPSA and PSA were not superior to NA in improving chronic pain (NPSA: mean difference [MD]= –4.77, 95% confidence interval [CI] –11.09 to 1.52; PSA: MD= –4.96, 95% CI –10.38 to 0.48). After NPSA and PSA were combined into the SA group, the weak trend of pain relief from SA was still not statistically significant (MD= –4.91, 95% CI –9.93 to 0.05). NPSA and PSA had similar effects (MD= 0.18, 95% CI –5.45 to 5.81). RA was significantly associated with pain relief, compared with NPSA and PSA (NPSA: MD= –12.03, 95% CI –16.62 to –7.41; PSA: MD= –11.85, 95% CI –15.48 to –8.23). The results were generally consistent regardless of pain phenotype, frequency, duration, acupuncture methods, analgesic intake, or detection bias. Conclusion These results suggested that acupuncture was significantly associated with reduced chronic pain. The two kinds of placebo acupuncture, NPSA and PSA, have similar effects. Both NPSA and PSA, with a weak but not significant effect, are appropriate to be inert placebo controls in RCTs for chronic pain. [ABSTRACT FROM AUTHOR]

Published
2023
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98. Rationale And Design of The Learning Implementation of Guideline-Based Decision Support System For Hypertension Treatment (LIGHT) Trial And LIGHT-ACD Trial

Author

Song, Jiali, primary, Wang, Xiu-Ling, additional, Wang, Bin, additional, Gao, Yan, additional, Liu, Jia-Min, additional, Zhang, Hai-Bo, additional, Li, Xi, additional, Li, Jing, additional, Wang, Ji-Guang, additional, Cai, Jun, additional, Herrin, Jeph, additional, Armitage, Jane, additional, Krumholz, Harlan M., additional, and Zheng, Xin, additional

Published
2021
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100. Hierarchical optimization of skull point cloud registration

Author

张海波 Zhang Hai-bo, 李 康 Li Kang, 刘晓宁 Liu Xiao-ning, 耿国华 Geng Guohua, 周明全 Zhou Ming-quan, and 杨 稳 Yang Wen

Subjects
Skull, medicine.anatomical_structure, Computer science, business.industry, medicine, Point cloud, Computer vision, Artificial intelligence, business, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Published
2019

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