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The Ni-catalyzed reactions of benzamides with bicyclic alkenes were explored using DFT calculations.

We propose an intramolecular synergistic counteracting strategy of fluorescence resonance energy transfer and the inner filter effect for accurate photoactivation monitoring, to eliminate the influence of the biological microenvironment.

To assess the efficacy of Sanyrene liquid dressing (Urgo Medical) in preventing radiation dermatitis (RD) among patients with cancer after radiotherapy.The authors searched the China National Knowledge Infrastructure, SinoMed, WanFang Data, PubMed, Web of Science, EMBASE, and the Cochrane Library databases for articles published from inception to January 2021.The preliminary search identified 146 studies. After removing duplicates, applying exclusion criteria, and screening titles and abstracts, 19 studies met the inclusion criteria.A standardized form was constructed to extract data from eligible studies. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of the included studies.The authors identified a total of 19 studies involving 1,508 patients that assessed the effectiveness of Sanyrene liquid dressing in preventing RD in patients with cancer after radiotherapy. The findings suggested that Sanyrene decreases the total incidence of RD (odds ratio [OR], 5.00; 95% CI, 2.77-9.03; P.00001), as well as the incidence of RD grade 2 (OR, 0.55; 95% CI, 0.36-0.85; P = .007), grade 3 (OR, 0.22; 95% CI, 0.09-0.57; P = .002), and grade 4 (OR, 0.32; 95% CI, 0.13-0.78; P = .01). In addition, in comparison with controls, Sanyrene liquid dressing improves the cure rate (OR, 8.18; 95% CI, 4.03-16.60; P.00001) and delays the occurrence of RD (mean difference, 3.69; 95% CI, 3.03-4.36; P.00001).Sanyrene liquid dressing can decrease both the total incidence of RD and the incidence of RD above grade 2. It also improves the cure rate and delays the occurrence of RD. Thus, Sanyrene may be a superior option for preventing RD after radiotherapy. However, the findings were assessed as moderate- to low-quality evidence and more high-quality trials are needed to support this result.

All solid-state batteries (ASSBs) are regarded as promising energy storage batteries with high energy density and high safety. The polyethylene oxide (PEO)-based electrolyte with succinonitrile (SN) has attracted critical attention for its high ionic conductivity at room temperature. However, SN can react with Li metal to result in an unstable interface between electrolyte and electrode, which deteriorates the electrochemical performance. In this work, zeolitic imidazolate framework-67 (ZIF-67) is used as a filler to construct composite electrolytes and solve the aforementioned instability issue. The composite electrolyte shows nonflammability, high processability, and a competitive ionic conductivity of 2.78 * 10

We established a dynamic duopoly game model with consumer surplus and isoelastic demand, and studied the local and global dynamic characteristics of the game model. The local stability of the boundary equilibrium point is examined by way of the stability theory and Jacobian matrix, and through the Jury criterion, the stable region of the Nash equilibrium point is determined. The analysis revealed that the system may lose stability via the Flip bifurcation and the Neimark-Sacker bifurcation. The effect of each parameter on the stability of the system is discussed in virtue of numerical simulations, and it is concluded that when enterprises choose relatively small the speed of adjustment, profit weight coefficient and marginal cost, as well as relatively large price elasticity coefficient, it is more beneficial to the future long-term development of enterprises. With the help of the basin of attraction, the problem of attractor coexistence is studied. Multiple stability always implies path dependence, implying that historical chance has a significant impact on the future behavior of enterprises. In other words, the slight perturbations of the initial conditions will have a significant impact on how the system develops. In addition, we investigate the system’s global dynamical behavior using critical curves, basins of attraction, attracting areas and the noninvertible map, and discover three global bifurcations of the system. The boundary of the chaotic attractor and the region with higher density of points are given by the critical curve.

Metalloporphyrin- and phosphonium-functionalized porous organic polymers (POPs) were fabricated successfully via a post-synthesis modification strategy, which were demonstrated to be efficient heterogeneous catalysts for CO2 conversion.

Modifying separator with metal oxides has been considered as a strong strategy to inhibit the shuttling of soluble polysulfide in the lithium-sulfur battery (Li-S battery). Manganese dioxide (MnO2), one kind of transition metal oxide, is widely applied to decorate the PP (Polypropylene) separator. However, the fabrication by physical coating is always multistep and complicated. Here, we design a simple and fast method to chemically decorate separator. Based on the oxidizing property of acidic KMnO4 solution, the PP separator was oxidized and an ultrathin self-assembled MnO2 layer was directly constructed on one side of separator, by immersing in acidic KMnO4 solution for only 1 h. The self-assembled MnO2 layer has the synergistic effect of adsorption and catalytic conversion on polysulfides, which can effectively inhibit the shuttle effect. It can also help battery to maintain excellent electrochemical kinetics in the electrochemical cycle and maintain the effective recycling of active substances. As a result, the shuttling of polysulfide is greatly prohibited by this novel functional separator, and cycling stability is outstandingly improved, with a low-capacity decaying of 0.058% after 500 cycles at 0.5C. The rapid and simple modification method proposed in this study has a certain reference value for the future large-scale application of lithium-sulfur battery.

The introduction of spinel phase to form the layered-spinel structure (LSS) is an effective way to improve the electrochemical performance of Li- and Mn-rich layered oxides (LMR). But is this structure universal for all LMR systems? In this work, different Mn/Ni ratio systems with the LSS are discussed in detail. It is found that, high discharge capacity (200.8 mA h g−1 at 1C rate; 1C = 250 mA h g−1) as well as high capacity-retention (94% at 1C rate after 100 cycles) can be achieved by forming the LSS for low-Ni system (Mn/Ni = 5.0). However, the capacity retention decreases severely in the high-Ni system (Mn/Ni = 3.5, 2.6). For example, when the ratio of Mn/Ni is 3.5, the capacity-retention of the layered-spinel sample was only 65.8%, compared to the 83% of the original LMR sample. The Ex-situ XRD, XPS, and HRTEM results demonstrate that the introduction of spinel phase in high-Ni system accelerates the transition and collapse of the crystal structure. This work provides guidance for optimizing the proportions of elements and the design of structures for the LMR.

The Ni-catalyzed reactions of benzamides with bicyclic alkenes were explored using DFT calculations. An unprecedented "N-H deprotonation circumvented" catalytic mechanism was proposed, over the more common N-H/C-H activation mechanism, in which (i) the circumvention of N-H deprotonation ensures the presence of N-H⋯O hydrogen bond interaction, thereby stabilizing the critical

Since the 1960s, levodopa (LDA) has been the standard drug for treating of Parkinson's disease. In this study, a novel benzothiadiazole-based conjugated microporous polymer-coated graphene heterostructure (CMP-rGO) was synthesized and used to construct a sensitive photoelectrochemical (PEC) sensor capable of detecting LDA. Under optimal experimental conditions, the intensity of the photocurrent produced by the sensor was linear from 0.005 to 40 μM, and the limit of detection of the sensor was 0.0027 μM. The sensor showed good repeatability, stability, and selectivity for LDA detection. Finally, the constructed sensor was used to detect LDA in levodopa tablets, human serum samples, and urine samples and satisfactory results were obtained. Therefore, the PEC sensor provides a novel platform for the detection of LDA in real samples and broadens the applications of conjugated microporous polymers in PEC sensing.

Li-rich layered oxides with high capacity are expected to be the next generation of cathode materials. However, the irreversible and sluggish anionic redox reaction leads to the O2 loss in the surface as well as the capacity and voltage fading. In the present study, a simple gas-solid treatment with ferrous oxalate has been proposed to uniformly coat a thin spinel phase layer with oxygen vacancy and simultaneously realize Fe-ion substitution in the surface. The integration of oxygen vacancy and spinel phase suppresses irreversible O2 release, prevents electrolyte corrosion, and promotes Li-ion diffusion. In addition, the surface doping of Fe-ion can further stabilize the structure. Accordingly, the treated Feox-2 % cathode exhibits superior capacity retention of 86.4 % and 85.5 % at 1 C and 2 C to that (75.3 % and 75.0 %) of the pristine sample after 300 cycles, respectively. Then, the voltage fading is significantly suppressed to 0.0011 V per cycle at 2 C especially. The encouraging results may play a significant role in paving the practical application of Li-rich layered oxides cathode.

As a secondary Li-ion battery with high energy density, lithium-sulfur (Li-S) batteries possess high potential development prospects. One of the important ingredients to improve the safety and energy density in Li-S batteries is the solid-state electrolyte. However, the poor ionic conductivity largely limits its application for the commercial market. At present, the gel electrolyte prepared by combining the electrolyte or ionic liquid with the all-solid electrolyte is an effective method to solve the low ion conductivity of the solid electrolyte. We present a cross-linked gel polymer electrolyte with fluoroethylene carbonate (FEC) as a solid electrolyte interface (SEI) film formed for Li-S quasi-solid-state batteries, which can be simply synthesized without initiators. This gel polymer electrolyte with FEC as an additive (GPE@FEC) possesses high ionic conductivity (0.830 × 10-3 S/cm at 25 °C and 1.577 × 10-3 S/cm at 85 °C) and extremely high Li-ion transference number (tLi+ = 0.674). In addition, the strong ability toward anchoring polysulfides resulting in the high electrochemical performance of Li-S batteries was confirmed in GPE@FEC by the diffusion experiment, X-ray photoelectron spectroscopy analysis (XPS), and scanning electron microscopy (SEM) mapping of the S element. Such a high ion conductivity (IC) gel polymer electrolyte enables a competitive specific capacity of 940 mAh/g at 0.2C and supreme cycling performance for 180 cycles at 0.5C, which is far beyond that of conventional poly(ethylene oxide)-based quasi-solid-state Li-S batteries.

Li-rich Mn-based cathodes have attracted much attention due to their high capacity stemming from anion redox above 4.5 V. However, the continuous activation of Li2MnO3 in Li-rich Mn-based materials, which correlates with O2 release and TM migration, is usually unfavorable to structural stability. Herein, based on a gas-solid interface reaction, we tackle this continuous activation phenomenon by restricting the capacity release of Li2MnO3 via NH4HCO3 treatment in the Li1.2Ni0.36Mn0.44O2 cathode. After modification, oxygen vacancies associated with the spinel phase are introduced on the surface. The 4 mol % NH4HCO3-modified material's capacity starts at 182 mAh g-1 at 1 C instead of increasing from 173 to 186 mAh g-1 for 25 cycles in the pristine material. Meanwhile, it also exhibits an excellent capacity retention of 93.24% after 200 cycles (at 1 C), with a small voltage decay rate of 1.19 mV cycle-1.

Amplification pretargeting has the potential to increase the tracer's accumulation in the tumor. This study aimed to develop a three-step amplification pretargeting strategy in nuclear medicine with a polymer conjugated with multiple copies of peptide nuclear acid (PNA). In this study, the tracer 18 F-labeled complementary PNA (18 F-cPNA) was prepared by click-chemistry with high radiochemical purity (>99%) and great stability in vitro. The PAMMA dendrimer generation 4 (G4) was conjugated with multiple copies of PNAs. The average number of PNA groups in the G4-PNA conjugate was determined by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and the accessibility to the 18 F-cPNA was identified by size-exclusion high-performance liquid chromatography (SE-HPLC). There were approximately 11.7 of 64 carboxyl groups modified with PNAs, of which more than 99% were accessible to 18 F-cPNA. 18 F-cPNA was added to a mixture of CC49-cPNA and G4-PNA, and the complex exhibited a single peak on high-performance liquid chromatography (HPLC) as evidence of complete hybridization between 18 F-cPNA and CC49-cPNA/G4-PNA. The LS174T tumor cells were incubated with CC49-cPNA followed by G4-PNA as an amplification platform before 18 F-cPNA was added to hybridize with CC49-cPNA/G4-PNA. Compared with conventional pretargeting without G4-PNA, the radioactivity signal was amplified about four times, which demonstrated that the dendrimer-PNA conjugate plays a crucial role in signal amplification.

Gleditsia sinensis is an endemic species widely distributed in China with high economic and medicinal value. To explore the genomic evolution and phylogenetic relationships of G. sinensis, the complete mitochondrial (mt) genome of G. sinensis was sequenced and assembled, which was firstly reported in Gleditsia. The mt genome was circular and 594,121 bp in length, including 37 protein-coding genes (PCGs), 19 transfer RNA (tRNA) genes and 3 ribosomal RNA (rRNA) genes. The overall base composition of the G. sinensis mt genome was 27.4% for A, 27.4% for T, 22.6% for G, 22.7% for C. The comparative analysis of PCGs in Fabaceae species showed that most of the ribosomal protein genes and succinate dehydrogenase genes were lost. In addition, we found that the rps4 gene was only lost in G. sinensis, whereas it was retained in other Fabaceae species. The phylogenetic analysis based on shared PCGs of 24 species (22 Fabaceae and 2 Solanaceae) showed that G. sinensis is evolutionarily closer to Senna species. In general, this research will provide valuable information for the evolution of G. sinensis and provide insight into the phylogenetic relationships within the family Fabaceae.

Vegetation phenology has been viewed as the nature's calendar and an integrative indicator of plant-climate interactions. The correct representation of vegetation phenology is important for models to accurately simulate the exchange of carbon, water, and energy between the vegetated land surface and the atmosphere. Remote sensing has advanced the monitoring of vegetation phenology by providing spatially and temporally continuous data that together with conventional ground observations offers a unique contribution to our knowledge about the environmental impact on ecosystems as well as the ecological adaptations and feedback to global climate change. Land surface phenology (LSP) is defined as the use of satellites to monitor seasonal dynamics in vegetated land surfaces and to estimate phenological transition dates. LSP, as an interdisciplinary subject among remote sensing, ecology, and biometeorology, has undergone rapid development over the past few decades. Recent advances in sensor technologies, as well as data fusion techniques, have enabled novel phenology retrieval algorithms that refine phenology details at even higher spatiotemporal resolutions, providing new insights into ecosystem dynamics. As such, here we summarize the recent advances in LSP and the associated opportunities for science applications. We focus on the remaining challenges, promising techniques, and emerging topics that together we believe will truly form the very frontier of the global LSP research field., Global Change Biology, 28 (24), ISSN:1354-1013, ISSN:1365-2486

Soil salinisation is an important factor limiting the cultivation and distribution of Prunus mume. Therefore, identifying the regulation mechanism of salt tolerance of P. mume will promote its cultivation and molecular breeding. In this study, the garden tree species P. mume ‘Meiren’ was investigated, with a soil NaCl content (w/w) of 0.3%. Photosynthetic gas exchange parameters, relative electrical conductivity, malondialdehyde, osmoregulation substances, and antioxidant enzyme activity were measured in the early (3d), middle (10d), and late (30d) stages of stress. Salt treatment was applied for 0 h, 6 h, 24 h, and 72 h; following this, the gene library was constructed from the leaves. The results showed that the CBL-CIPK, mitogen-activated protein kinase, calcium-dependent protein kinase, and abscisic acid signalling pathways were involved in salt stress signal transduction of P. mume. Furthermore, bHLH, WRPK, ERF, and MYB were identified as potential key transcription factor families of salt tolerance in P. mume. Combined with determined physiological responses, the results showed that early salt stress inhibited the activities of RuBisCO, chlorophyll synthase, glutamyl tRNA reductase, divinyl reductase, and magnesium chelatase; resultantly, this led to a reduction in the photosynthetic rate. Also, it was found that P5CS, SS, LEA, and dehydrin regulated the synthesis of proline, soluble sugar, and macromolecular protein to alleviate osmotic stress. POD gene plays an important role in scavenging reactive oxygen species due to its regulation of POD activity. The findings of this research reveal the internal mechanism of the physiological response and provide a foundation for the construction of a genetic regulatory network in response to salt stress in P. mume.

The continuous growth of the solid-electrolyte interface (SEI) and material crushing are the fundamental issues that hinder the application of Ge anodes in lithium-ion batteries. Solving Ge deformation crushing during discharge/charge cycles is challenging using conventional carbon coating modification methods. Due to the chemical stability and high melting point of carbon (3500 °C), Ge/carbon hybridization at the atomic level is challenging. By selecting a suitable carbon source and introducing an active medium, we have achieved the Ge/carbon doping at the atom-level, and this Ge/carbon anode shows excellent electrochemical performance. The reversible capacity is maintained at 1127 mAh g-1 after 1000 cycles (2 A g-1 (2-71 cycles), 4 A g-1 (72-1000 cycles)) with a retention of 84 % compared to the second cycle. The thickness of the SEI is only 17.4 nm after 1000 cycles. The excellent electrochemical performance and stable SEI fully reflect the application potential of this material.

Binders have been confirmed to play a significant role in improving the cycling performance of Si anode. Some of natural biogum binders are exploited and related progresses are also achieved. However, the distinction of characteristics among different biogum binders as well as corresponding mechanisms and principles still remain to be elucidated. In this study, gum arabic (GA), guar gum (GG), and xanthan gum (XG) are selected for comparison. The highest initial Coulombic efficiency (ICE) of 90.4% is obtained with GA owing to diverse multiple interactions with Si nanoparticles to form a homogeneous covering that could protect Si core against being exposed to electrolyte and generating SEI film, as well as strong covalent network to suppress the isolation of Si, while plastic damage occurs during repeated volume change of Si because of irreversible bonding nature. By contrast, hydrogen bonding between polar –OH groups with self-healing nature provides Si anodes with GG and XG better cycling stability, while the optimized capacity of 1323 mAh g−1 after 100 cycles is retained with GG due to the extra ability to transfer Li+. This study provides the design and selection principles for binders applied in Si anodes of lithium-ion batteries.

A binder is an important component in lithium-ion batteries and plays a significant role in maintaining the properties of active substances. Most studies in the field of binders have only focussed on physical properties such as bonding performance. Here, a polyacrylic acid-modified binder was designed and adapted to Li[Ni0.8Co0.1Mn0.1]O2, which enhanced the electrochemical stability of Li[Ni0.8Co0.1Mn0.1]O2 from 30.2 to 66.6% (300 cycles at 1 C). We for the first time discovered that this was caused by a chemical reaction between polyacrylic acid and the residual lithium on the surface during the cycling, which formed a lithium propionic acid coating layer and maintained the stability of the layered structure.

Nickel-rich layered transition metal oxides are considered as promising cathode candidates to construct next-generation lithium-ion batteries to satisfy the demands of electrical vehicles, because of the high energy density, low cost, and environment friendliness. However, some problems related to rate capability, structure stability, and safety still hamper their commercial application. In this Review, beginning with the relationships between the physicochemical properties and electrochemical performance, the underlying mechanisms of the capacity/voltage fade and the unstable structure of Ni-rich cathodes are deeply analyzed. Furthermore, the recent research progress of Ni-rich oxide cathode materials through element doping, surface modification, and structure tuning are summarized. Finally, this review concludes by discussing new insights to expand the field of Ni-rich oxides and promote practical applications.

Phenyl-1,2-benzoselenazol-3(2H)-one (ebselen) is a classical mimic of glutathione peroxidase (GPx). Thioredoxin interaction endows ebselen attractive biological functions, such as antioxidation and anti-infection, as well as versatile therapeutic usage. Accordingly, application of ebselen analogues in biosensing, chemical labeling, imaging analysis, disease pathology, drug development, clinical treatment, etc. have been widely developed, in which mercaptans, reactive oxygen species, reactive sulfur species, peptides, and proteins were involved. Herein, focusing on the application of ebselen-agents in biochemistry, we have made a systematic summary and comprehensive review. First, we summarized both the classical and the innovative methods for preparing ebselen-agents to present the synthetic strategies. Then we discussed the full functional applicability of ebselen analogues in three fields of biochemical analysis including the fluorescence sensing and bioimaging, derivatization for high throughput fluorescence analysis, and the labeling gents for proteomics. Finally, we discussed the current challenges and perspectives for ebselen-agents as analytical tools in biological research. By presenting the multifunctional applicability of ebselen, we hope this review could appeal researchers to design the ebselen-related biomaterials for biochemical analysis.

Motivated by attributes including environmental hazards and resource value, the recycling of the spent graphite has aroused increasing attention. Meanwhile, a silicon/graphite composite has been considered as a promising high-capacity anode for lithium-ion batteries. However, uniform dispersion and outperformed stability of silicon (Si) particles in the graphite matrix still remain a great challenge. Current solutions mainly focus on the design of Si nanostructures and the overall architecture of the silicon/graphite composite, while little attention has been paid to the graphite matrix. Herein, the Si/spent graphite (Si/SG) composite was prepared based on the recycling of SG. The SG was in situ modified during the battery cycling process and formed unique physicochemical properties. By spontaneously tuning the zeta potential, the electrostatic force integrated the Si nanoparticles within the SG matrix to restrain the volume strain upon lithiation/delithiation. Besides, defect-enriched and exfoliated SG can effectively enhance the electric conductivity, facilitating the electrochemical kinetics in the electrodes. What is more, the oxygen-containing functional groups on the SG could adjust the solid electrolyte interphase (SEI) component by generating more organic components to improve the mechanical toughness of the SEI layer. Consequently, the Si/SG composite electrode delivers a high initial discharge capacity of 1321.8 mA h g−1 at 0.05 A g−1 and stable cycle life with a capacity retention of 69% at 1 A g−1 after 400 cycles. The proposed composite may provide some guidelines for improving the interface stability of the Si/graphite anode and simultaneously the high-value application of spent graphite.

Recycling and reusing spent graphite have become urgent tasks, with massive numbers of lithium-ion batteries (LIBs) from hybrid electric vehicles (HEVs)/electric vehicles (EVs) retired every year. Meanwhile, interlayer designs based on carbon materials have attracted widespread attention to suppress the polysulfide shuttle effect in high-energy-density lithium–sulfur (Li–S) batteries. Nevertheless, designing simple and low-cost carbon-derived interlayers still remains a great challenge. Spent graphite possesses a porous structure, defects, and polar functional groups that were formed in situ, which can significantly confine polysulfides through a combination of physical and chemical adsorption. Meanwhile, transition metals introduced due to the dissolution of cathode active materials can also anchor polysulfides via S–TM bonding, as well as improving electrical conductivity and boosting polysulfide conversion kinetics. Herein, spent graphite recycled from waste LIBs was employed for the first time as a functional interlayer for Li–S batteries based on its intrinsic properties. The spent-graphite-derived interlayer exhibited remarkably enhanced trapping and catalytic performance toward polysulfides. A high discharge capacity of 968 mA h g−1 with a low decay rate of 0.08% per cycle over 500 cycles at 1 C can be obtained. The present work not only provides a promising strategy for the design of interlayers, but it also shows a high-value application of spent graphite.

Sodium-ion batteries (SIBs) have shown promising prospects for complementarity to lithium-ion batteries (LIBs) in the field of grid-scale energy storage. After a decade of continuous fundamental research on SIBs, it's becoming increasingly urgent to advance the commercialization. For SIB anode materials, hard carbon is the most mature and currently the only material likely to be commercialized, but it is still far away from large-scale industrialization. Herein, we carry out a comprehensive overview of the current state of the art in terms of three main aspects. Firstly, a fundamental understanding of the microstructure and sodium storage mechanism of hard carbon is introduced, which can be categorized into three different processes: capacitive adsorption, nanopore filling, and intercalation in carbon interlayers. Then, based on an in-depth understanding of the sodium storage mechanism, optimization methods in terms of increasing the specific capacity, rate performance, initial coulombic efficiency (ICE), and long-cycling stability are comprehensively summarized and analyzed. Finally, potential methods and associated benefits for the design of carbon structures and the solid electrolyte interface (SEI) are discussed, hoping to provide useful guidelines for future research and commercialization.

Reducing the interfacial resistance between solid electrolytes and electrodes is critical for developing high-energy density solid-state batteries. In the present study, a simple strategy of designing an integrated cathode and solid electrolyte (ICSE) to avoid a contact interface is proposed and successfully fulfilled with the help of UV curving. Firstly, a porous polymer film (PVDF-HFP/PVDF) was formed on the surface of the porous LiFePO4 electrode via PVP dissolution. Secondly, curable monomers, including PEGDA/PETMP/TFEMA, were filled into the porous membrane via infiltration and concentration. Lastly, the ICSE was obtained via curing with ultraviolet light. The as-prepared LiFePO4//ICSE//Li solid battery displays excellent electrochemical performance with a high reversible capacity of 153 mA h g-1 and a capacity of over 140 mA h g-1 was retained after 150 cycles at 0.1C and 25 °C. This ICSE strategy may effectively contribute to the practical application of all-solid-state batteries.

C-reactive protein (CRP) has been shown to predict antidepressant treatment outcomes in several trials, but they were limited to small-sample and strictly-restricted conditions. This study plans to verify if CRP can predict antidepressant efficacy in large samples in the real world.918 depressed patients who had tested CRP were included, then were followed up through their outpatient visits or by telephone to obtain information about their medication therapy (SSRIs, SNRIs, MT, NaSSA) and assess efficacy using the Clinical Global Impressions-Improvement scale (CGII). Efficacy was classified as effective and ineffective and CRP was separated into the low CRP group (CRP1 mg/L, n = 709) and the high CRP group (CRP ≥1 mg/L, n = 209).The efficacy was compared in different groups.Using Kaplan-Meier survival analysis and Cox proportional regression model to analyze, it was discovered that SNRIs were more effective than SSRIs in treating patients with high CRP(HR = 1.652, p = 0.037,95 % CI:1.031-2.654), and SSRIs were more effective in treating patients with low CRP than those with high CRP (HR = 1.257, p = 0.047,95 % CI:1.003-1.574), while no difference in efficacy between the two groups was found in patients using SNRIs, MT, NaSSA.Small amounts of MT and NaSSA were included, and some factors that may affect CRP value have not been controlled.CRP could predict the efficacy of SSRIs in the real world, depressed patients with high CRP may be more likely to respond poorly to SSRIs.

Ni-rich lithium nickel cobalt aluminum oxide (NCA) cathodes, as one of the most promising candidates for the extended electric vehicle applications, have been widely recognized and attracted global...

Interactions between microorganisms and clay minerals influence the transport and cycling of metal contaminants in both marine and terrestrial environments. The present study was conducted to quantify the adsorption of dissolved cadmium, Cd(II), under seawater-like conditions to the marine cyanobacterium Synechococcus sp. PCC 7002, three common clay minerals (kaolinite, montmorillonite and illite), as well as cell-clay aggregates. We show here that the Synechococcus-only experiments removed the most Cd above pH 5.5, followed in decreasing order by aggregates of 50% cells:50% individual clays, aggregates of cells and all 3 clays, and individual clays. Electron microscope imaging showed that clays associated in a tangential edge-on orientation to the cells in Synechococcus-clay mineral aggregates. A non-electrostatic surface complexation modeling approach was used to fit Cd adsorption onto Synechococcus cells and individual clay minerals. The resulting Cd binding constants were then used in consort with surface functional group pKa values and site concentrations to accurately predict the extent of Cd adsorption onto the Synechococcus-clay mineral aggregates using the component additivity (CA) approach. We observed that the addition of cyanobacterial cells to clay mineral suspensions led to significantly larger mean aggregate sizes of clay minerals, enhancing the clay sedimentation rate. Although specifically focused on Cd, our study indicates that the ratio of bacterial plankton to clay minerals is an important determinant in terms of understanding the rate with which metals are transferred from the water column to the seafloor.

Energy storage devices are indispensable for supporting human activities; thus, producing sustainable environmental energy is a current focus of attention. Lithium–sulfur batteries (Li–S batteries)...

Au(I)-catalyzed selective reactions of Et- and tBu-substituted propiolates (1a and 1a′) with 1,2-benzisoxazole(2a) provide a new strategy for purposefully access to desired bioactive heterocycles. ...

N-doped straw sheaf–like porous MnO@C composite is synthesized through a L-histidine-assisted hydrothermal method with consequent annealing in Ar. The straw sheaf–like porous structure is assembled by MnO nanoparticles with a diameter of ~ 15 nm and be uniformly wrapped in amorphous N-doped carbon matrix. MnO@C-N displays attractive electrochemical properties when used as anode of lithium-/sodium-ion batteries. A high reversible capacity of 832.5 mA h g−1 could be obtained at 100 mA g−1 in LIBs and 250 mA h g−1 at 50 mA g−1 with outstanding cycling stability in SIBs. The study also compared MnO@C-N with commercial MnO particles in LIBs and shows that MnO@C-N anode has excellent cycling performance with 614.0 mA h g−1 retained after 200 cycles. However, commercial MnO displays only 413.5 mA h g−1 after 132 cycles. The present synthesis strategy opens the possibility of fabricating MnO@C-N nanocomposites for high-performance batteries.

Lithium-rich cathode oxides exhibit extraordinary specific capacities that are mainly ascribed to the accumulated redox reactions of anions and cations at high operating potentials. However, rapid ...

The Ni-rich cathodes are considered as the next generation candidate cathode material of lithium-ion batteries due to the high-energy–density and environmentally friendly. Unfortunately, the cathodes are up against severe structure instability at the repeated charge/discharge process, resulting in the attenuation of voltage and capacity. Herein, we proposed a novel strategy with uniform Al and Ti cations co-doping of LiNi0.8Co0.1Mn0.1O2 cathode. The modification strategy not only stabilizes the vulnerable layered structure but also mitigate voltage/capacity attenuation at different cutoff voltages. As a result, the modified cathode with trace content of Al and Ti cations co-doping can broaden the lithium ions diffusion channels, mitigate the structural collapse, and unfavorable phase transformation to some extent. Specifically, the modified sample exhibits remarkable enhanced electrochemical performance in discharge capacity and voltage retention of 76.75%, 98.78% at 1 C after 200 cycles. Even though at elevated voltage, the modified sample shows improved cycle life with a capacity retention of 70.93% after 200 cycles.

The increased application of layered oxide (LiCoO2) lithium ion batteries (LIBs) for electronic products will result in lots of spent layered cathodes in the near future. Furthermore, the explorati...