176 results on '"Yueyang Liu"'
Search Results
52. Distinguishing Interfacial Hole Traps in (110), (100) High-K Gate Stack.
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Yueyang Liu, Xiangwei Jiang, Liwei Wang 0003, Yunfei En, and Runsheng Wang
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- 2019
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53. Gaussian Imagination in Bandit Learning.
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Yueyang Liu, Adithya M. Devraj, Benjamin Van Roy, and Kuang Xu
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- 2022
54. Nonstationary Bandit Learning via Predictive Sampling.
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Yueyang Liu, Benjamin Van Roy, and Kuang Xu
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- 2022
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55. AED: An black-box NLP classifier model attacker.
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Yueyang Liu, Yan Huang 0032, and Zhipeng Cai 0001
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- 2023
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56. Robust Convergence in Federated Learning through Label-wise Clustering.
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Hunmin Lee, Yueyang Liu, Donghyun Kim 0001, and Yingshu Li
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- 2021
57. An Attention Score Based Attacker for Black-box NLP Classifier.
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Yueyang Liu, Hunmin Lee, and Zhipeng Cai 0001
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- 2021
58. Repression of miR-146a in predicting poor treatment outcome in triple-negative breast cancer
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Konstantina, Panoutsopoulou, Yueyang, Liu, Margaritis, Avgeris, Tobias, Dreyer, Julia, Dorn, Viktor, Magdolen, and Andreas, Scorilas
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Clinical Biochemistry ,General Medicine - Abstract
In the era of precision medicine, the highly aggressive and heterogenous triple-negative breast cancer (TNBC) is still characterized by limited options to support personalized prognosis and guide therapeutic interventions. Thereafter, the aim of the present study has been the thorough evaluation of miR-146a as a novel molecular indicator of TNBC prognosis and treatment outcome, utilizing four independent TNBC cohorts.miR-146a levels were clinically evaluated in our screening (n=122) and three external validation TNBC cohorts (de Rinaldis et al. 2013, n=114; Jézéquel et al. 2015, n=107; TCGA, n=180). Analysis of miR-146a and validated gene targets was performed in Jézéquel et al. and TCGA validation cohorts. Patients' survival, recurrence and metastasis were determined as clinical endpoints for the survival analysis. Internal validation was performed by bootstrap analysis and clinical net benefit was evaluated by decision curve analysis.Reduction of miR-146a is strongly associated with patients' poor survival and can predict post-treatment disease early-recurrence, independently of tumor size, lymph node status, histological grade and patients' age. The analysis of the external validation cohorts corroborated the unfavorable nature of miR-146a repression regarding patients' survival and, strikingly, unveiled the ability of miR-146a to predict TNBC metastasis. Combined assessment of miR-146a levels and lymph node status resulted in superior risk-stratification of TNBC patients and higher clinical benefit regarding disease prognosis and post-treatment outcome. Ultimately, miR-146a was negatively associated with EGFR and SOX2 expression in TNBC.miR-146a evaluation could ameliorate personalized prognosis and support precision medicine decisions in TNBC.
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- 2023
59. Measured reflection and transmission properties of building materials for indoor THz communication
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Yang Wang, Yueyang Liu, Xi Liao, Yu Shao, Ziming Yu, Guangjian Wang, and Xianjin Li
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Electrical and Electronic Engineering - Published
- 2023
60. The microstructural abnormalities of cingulum was related to patients with mild cognitive impairment: a diffusion kurtosis imaging study
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Yueyang Liu, Dongtao Liu, Mingyong Liu, Kun Li, Qinglei Shi, Chenlong Wang, Zhenyu Pan, and Lichun Zhou
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Psychiatry and Mental health ,Neurology (clinical) ,Dermatology ,General Medicine - Abstract
Objective Our study aimed to investigate the correlations between microstructural changes of cingulum and patients with mild cognitive impairment (MCI) by diffusion kurtosis imaging (DKI) technique. Method A total of 104 patients with cerebral small vessel diseases (cSVD) were retrospectively enrolled in this study. According to Montreal Cognitive Assessment Scale (MoCA) scores, these patients were divided into MCI group (n = 59) and non-MCI group (n = 45). The general clinical data was collected and analyzed. The regions of interests (ROIs) were selected for investigation in cingulum. The values of DKI parameters were measured in each ROI and compared between the two groups, the correlations between DKI parameters and MoCA scores were examined. Results Compared to non-MCI group, MCI patients had more severe white matter hyperintensities (WMHs) (P = 0.038) and lower MoCA scores (P P r = 0.348, 0.409, 0.310, 0.441, 0.422, all P r = 0.338, 0.352, 0.289, 0.380, 0.370, all P Conclusion DKI technique could be used to explore the microstructural changes of cingulum in MCI patients and DKI-derived parameters might be feasible to evaluate MCI patients.
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- 2022
61. Enhanced Optical Transmission through a Hybrid Bull’s Eye Structure Integrated with a Silicon Hemisphere
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Zhang, Yueyang Liu, Jiukai Fang, Yuwen Lin, Shengnan Shi, Chengzhe Di, Shan Zhang, Mingqi Sun, Yanpeng Shi, and Yifei
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extraordinary optical transmission ,surface plasmon ,terahertz ,bull’s eye structure ,Mie resonance - Abstract
In this work, we demonstrate a novel structure that can generate extraordinary optical transmission with a silicon hemisphere placed on a conventional bull’s eye structure. There is a single subwavelength aperture surrounded by concentric periodic grooves on a substrate. The extraordinary optical transmission in this work is realized by the coupling of the surface plasmon polaritons in the periodic grooves and the localized electromagnetic field generated by the Mie resonance in the silicon hemisphere. The maximum normalized-to-area transmission peak can reach up to 662 with a decreasing device area and size. The electromagnetic field distribution at different geometry parameters is analyzed to clarify the mechanisms of the work in this paper. Additionally, the use of dielectric material in the aperture can avoid ohmic losses of metal material compared with the conventional one, which may suggest that a wider range of bull’s-eye-structure applications is possible.
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- 2023
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62. Phosphorylation of STAT3 at Tyr705 contributes to TFEB-mediated autophagy-lysosomal pathway dysfunction and leads to ischemic injury in rats
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Yueyang Liu, Xiaohang Che, Xiangnan Yu, Hanxiao Shang, Peirui Cui, Xiaoxiao Fu, Xianda Lu, Yuhuan Liu, Chunfu Wu, and Jingyu Yang
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Pharmacology ,Cellular and Molecular Neuroscience ,Molecular Medicine ,Cell Biology ,Molecular Biology - Published
- 2023
63. Construction and validation of an anoikis-related gene prognostic signature in ovarian cancer
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Zhenye Tang, Shuting Huang, Dajiang Liu, Yueyang Liu, Jing Chen, Chenfei Zhou, and Shanyang He
- Abstract
Ovarian cancer (OC) is identified as one of the most aggressive malignant diseases that imperil women health. Anoikis has been proved to be significantly correlated with the aggressiveness of dislodged cancer cells and poor prognosis of cancer patients. Currently, few researches focus on the prognostic role of anoikis-related genes (AIRGs) on the OC cases. Here, we firstly and systematically analyzed the predictive ability of AIRGS on the prognosis of patients with OC. The genomics data and clinicopathologic information of OC patients were retrieved from TCGA project. Univariate Cox regression and least absolute shrinkage and selection operator (LASSO) method were executed to construct an anoikis–related risk score (AIRS) indicator based on 11 AIRGs. ICGC-OV and GSE26712 were used as independent validation datasets. A nomogram integrated AIRS and pathologic parameters, survival analysis and time-dependent receiver operating characteristic (ROC) curves were utilized to assess the predictive performance of this signature. Successfully, OC patients were divided into two sets based on the optimum cut-off value of risk scores. High risk category evidently suffers from more unfavorable survival outcomes. What is more, AIRS was closely connected with tumor microenvironment (TME) characteristics, mutant landscape, m6A modification and clinical implications. Interestingly, we validated EML2 as a crucial risk gene in OC based on GSEA, single-cell analysis and immunohistochemical staining results. Collectively, AIRS was validated as an independent prognostic indicator with good predictive validity in OC. It can function as a robust clinical parameter which effectively stratifies OC patients and promotes the development of precise medicine.
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- 2023
64. Velocity-Free Saturated Control for Spacecraft Proximity Operations With Guaranteed Safety
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Yueyang Liu, Qinglei Hu, and Youmin Zhang
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Lyapunov function ,Spacecraft ,Computer simulation ,business.industry ,Computer science ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,Stability (probability) ,Computer Science Applications ,Human-Computer Interaction ,Maxima and minima ,symbols.namesake ,Control and Systems Engineering ,Control theory ,Control limits ,symbols ,Electrical and Electronic Engineering ,Actuator ,business ,Software - Abstract
This article details the development and evaluation of a practical solution for path-constrained proximity maneuvers of spacecraft. Whereas no velocity measurement is utilized within the feedback structure, the controller rigorously enforces actuator magnitude constraints. Specifically, the control algorithm is constructed from a potential function method repelling the spacecraft from possible collisions. The proposed controller can guarantee potential functions to be navigated to the origin and thus overcome the stubborn local minima problem. Moreover, the control capability under any given control limit can be estimated and adjusted by changing the feedback gains. The specific performance with guaranteed safety can be also explicitly calculated by designers. The results are obtained through a Lyapunov-based stability analysis to prove uniformly ultimate boundedness. Numerical simulation results illustrate the performance and features of the developed control method.
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- 2022
65. Land Use/Land Cover Evaluation Using Trajectory Maps Based on Landsat TM/OLI in Southwest China
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Wenfeng Gong, Tiedong Liu, Tao Liu, Xuanyu Duan, Yueyang Liu, and Philip Stott
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Renewable Energy, Sustainability and the Environment ,General Environmental Science - Abstract
This study mainly aims to detect the county-level spatio-temporal variability of LULCC (Land Use and Land Cover Change) spatial patterns in Southwest China. Multi-temporal Remote Sensing (RS) images (Landsat TM/OLI in 2000, 2005, 2010, and 2015) were applied to extract land use/cover types at each of the four-time nodes using the Support Vector Machine (SVM) method. Then, the trajectory map methodology was adopted to identify the spatio-temporal distribution characteristics of LULCC patterns throughout the given time series. According to the results, the area of unused land decreased continuously, 0.094% total. An evident decline of grassland by 2.17% was documented, and a notable increase was observed in forestland by 63.94 km2 during the period from 2000 to 2015. Water bodies, built-up land, and unused land showed no significant change throughout the study period. The conversion from grassland to forestland and vice-versa (code 13 or 31) was prominent due to an adjustment made to local forestry policy during the first two periods (2000-2005 and 2005-2010), accounting for 17.55% and 17.56% of the study region, respectively. The anaphase trajectory transition type occupied the smallest area of all the trajectory maps. By contrast, the repetitive trajectory was the leading land-use transition type and covered the largest area. Trajectory analysis provides an effective approach for detecting the spatio-temporal changes in LULCC patterns.
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- 2022
66. Inhibition of YAP activation attenuates renal injury and fibrosis in angiotensin II hypertensive mice
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Ruiping Cai, Qian Xu, Junjie Zhang, Ming-Sheng Zhou, Yang Yao, Yueyang Liu, and Fu Ren
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Male ,0301 basic medicine ,Hypertension, Renal ,Physiology ,Blood Pressure ,Inflammation ,Protein Serine-Threonine Kinases ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Transforming Growth Factor beta ,Fibrosis ,Physiology (medical) ,medicine ,Renal fibrosis ,Animals ,Vasoconstrictor Agents ,Chemokine CCL2 ,Tissue homeostasis ,Pharmacology ,Hippo signaling pathway ,Nephritis ,Photosensitizing Agents ,Effector ,business.industry ,Angiotensin II ,Verteporfin ,YAP-Signaling Proteins ,General Medicine ,Acute Kidney Injury ,medicine.disease ,Mice, Inbred C57BL ,030104 developmental biology ,Hypertension ,Cancer research ,medicine.symptom ,Signal transduction ,business ,Signal Transduction - Abstract
The Hippo/YAP (yes-associated protein) pathway is an important signaling pathway to control organ development and tissue homeostasis. YAP is a downstream effector of the Hippo pathway and a critical mediator of mechanic stress. Hypertensive nephropathy is characterized with glomerular sclerosis stiffness and renal fibrosis. The present study investigated the role of YAP pathway in angiotensin (Ang) II hypertensive renal injury by using YAP activation inhibitor verteporfin. Ang II increased the protein expression of YAP in renal nucleus fraction, decreased phospho-YAP, and phospho-LATS1/2 (large tumor suppressors 1 and 2) expressions in renal cytoplasmic fraction, suggesting Ang II activation of renal YAP. Ang II significantly increased systolic blood pressure (SBP), proteinuria, glomerular sclerosis, and fibrosis; treatment with verteporfin attenuated Ang II–induced proteinuria and renal injury with a mild reduction in SBP. Moreover, Ang II increased the protein expressions of inflammatory factors including tumor necrosis factor α, interleukin 1β, and monocyte chemoattractant protein-1, and profibrotic factors including transforming growth factor β, phospho-Smad3 and fibronectin. Verteporfin reversed abovementioned Ang II–induced molecule expressions. Our results for the first time demonstrate that the activation of the YAP pathway promotes hypertensive renal inflammation and fibrosis, which may promote hypertensive renal injury. YAP may be a new target for prevention and treatment of hypertensive renal diseases.
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- 2021
67. On the Cultivation of Intercultural Communicative Competence in the English Viewing-listening-speaking Course
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Yueyang Liu
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Communicative competence ,Linguistics and Language ,Class (computer programming) ,Globalization ,Interpretation (philosophy) ,ComputingMilieux_COMPUTERSANDEDUCATION ,Mathematics education ,Active listening ,English language ,Psychology ,Language and Linguistics ,Research data ,Pace - Abstract
With the fast pace of globalization, cultivating Intercultural Communicative Competence (ICC) has gradually become a vital goal in English language teaching. However, whether the English Viewing-Listening-Speaking (VLS) course can be used to improve learners’ ICC is less researched. This paper tends to adopt skills of discovery, comparison and analysis in Byram’s ICC model as methods to explore how students interpret in VLS class and how the interpretation processes improve students’ intercultural communicative competence. The design and implementation of teaching activities, combined with the research data including quizzes, students’ statement recording and reports, are introduced to illustrate how to improve learners’ ICC in VLS course.
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- 2021
68. Magnetically tunable zero-index metamaterials
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Lei Bi, Yucong Yang, Yueyang Liu, Jun Qin, Songgang Cai, Jiejun Su, Peiheng Zhou, Longjiang Deng, and Yang Li
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Physics::Optics ,FOS: Physical sciences ,Physics - Applied Physics ,Applied Physics (physics.app-ph) ,Physics - Optics ,Optics (physics.optics) - Abstract
Zero-index metamaterials (ZIMs) feature a uniform electromagnetic mode over a large area in arbitrary shapes, enabling many applications including high-transmission supercouplers with arbitrary shapes, direction-independent phase matching for nonlinear optics, and collective emission of many quantum emitters. However, most ZIMs reported till date are passive, with no method for the dynamic modulation of their electromagnetic properties. Here, we design and fabricate a magnetically tunable ZIM consisting of yttrium iron garnet (YIG) pillars sandwiched between two copper clad laminates in the microwave regime. By harnessing the Cotton-Mouton effect of YIG, the metamaterial was successfully toggled between gapless and bandgap states, leading to a "phase transition" between a zero-index phase and a single negative phase of the metamaterial. Using an S-shaped ZIM supercoupler, we experimentally demonstrated a tunable supercoupling state with a low intrinsic loss of 0.95 dB and a high extinction ratio of up to 30.63 dB at 9 GHz. Our work enables dynamic modulation of the electromagnetic characteristics of ZIMs, enabling various applications in tunable linear, nonlinear, quantum and nonreciprocal electromagnetic devices.
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- 2022
69. Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice
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Yeshu Liu, Yan Mi, Yongping Wang, Qingqi Meng, Libin Xu, Yueyang Liu, Di Zhou, Yingjie Wang, Dong Liang, Wei Li, Ning Li, and Yue Hou
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Pharmacology ,Complementary and alternative medicine ,Drug Discovery ,Pharmaceutical Science ,Molecular Medicine - Published
- 2023
70. Space-time resolved inference-based whole-brain neurophysiological mechanism imaging: application to resting-state alpha rhythm
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Yun Zhao, Mario Boley, Andria Pelentritou, Philippa J. Karoly, Dean R. Freestone, Yueyang Liu, Suresh Muthukumaraswamy, William Woods, David Liley, and Levin Kuhlmann
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Neural mechanisms are complex and difficult to image. This paper presents a new space-time resolved whole-brain imaging framework, called Neurophysiological Mechanism Imaging (NMI), that identifies neurophysiological mechanisms within cerebral cortex at the macroscopic scale. By fitting neural mass models to electromagnetic source imaging data using a novel nonlinear inference method, population averaged membrane potentials and synaptic connection strengths are efficiently and accurately imaged across the whole brain at a resolution afforded by source imaging. The efficiency of the framework enables return of the augmented source imaging results overnight using high performance computing. This suggests it can be used as a practical and novel imaging tool. To demonstrate the framework, it has been applied to resting-state magnetoencephalographic source estimates. The results suggest that endogenous inputs to cingulate, occipital, and inferior frontal cortex are essential modulators of resting-state alpha power. Moreover, endogenous input and inhibitory and excitatory neural populations play varied roles in mediating alpha power in different resting-state sub-networks. The framework can be applied to arbitrary neural mass models and has broad applicability to image neural mechanisms in different brain states.HighlightsThe whole-brain imaging framework can disclose the neurophysiological substrates of complicated brain functions in a spatiotemporal manner.Developed a semi-analytical Kalman filter to estimate neurophysiological variables in the nonlinear neural mass model efficiently and accurately from large-scale electromagnetic time-series.The semi-analytical Kalman filter is 7.5 times faster and 5% more accurate in estimating model parameters than the unscented Kalman filter.Provided several group-level statistical observations based on neurophysiological variables and visualised them in a whole-brain manner to show different perspectives of neurophysiological mechanisms.Applied the framework to study resting-state alpha oscillation and found novel relationships between local neurophysiological variables in specific brain regions and alpha power.
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- 2022
71. Effect of respiratory training on respiratory failure secondary to unilateral phrenic nerve injury: A case report
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Dawei Li, Zhendong Li, Zhiyou Zhang, Yueyang Liu, Congcong Wang, and Aixia Cheng
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General Medicine - Published
- 2023
72. Family with sequence similarity 46 member a confers chemo-resistance to ovarian carcinoma via TGF-β/Smad2 signaling
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Suiying Liang, Lanying Li, Tian Gao, Yueyang Liu, Shanyang He, and Jianhui He
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Ovarian Neoplasms ,Carcinoma ,Bioengineering ,General Medicine ,Smad2 Protein ,Biology ,Carcinoma, Ovarian Epithelial ,Applied Microbiology and Biotechnology ,Similarity (network science) ,Transforming Growth Factor beta ,Ovarian carcinoma ,Cell Line, Tumor ,Cancer research ,Humans ,Female ,Chemo resistance ,Transforming growth factor ,Sequence (medicine) ,Biotechnology ,Signal Transduction - Abstract
Purpose: Ovarian cancer is the most lethal malignancy with depressive 5-year survival rate, mainly due to patients with advanced stages experience tumor recurrence and resistance to the current chemotherapeutic agents. Thus, discovering the underlying molecular mechanisms involved in chemo-resistance is crucial for management of treatment to improve therapeutic outcomes. Methods: The protein and mRNA expression of FAM46A in ovarian cancer cell lines and patient tissues were determined using Real-time PCR and Western blot and IHC respectively. Functional assays, such as MTT, FACS assay used to determine the oncogenic role of FAM46A in human ovarian cancer progression. Furthermore, western blotting and luciferase assay were used to determine the mechanism of FAM46A promotes chemoresistance in ovarian cancer cells. Results: In the current study, we found overexpression of FAM46A expression in ovarian cancer patients demonstrated an aggressive phenotype and poor prognosis. Furthermore, FAM46A overexpression in ovarian cancer cells demonstrated higher CDDP resistance ability; however, inhibition of FAM46A sensitized ovarian cancer cell lines to CDDP cytotoxicity both in vitro and in vivo. Mechanically, upregulation of FAM46A activated transforming growth factor-β (TGF-β)/Smad signaling and upregulated the levels of nuclear Smad2. Conclusions: Taken together, our results highlight the important oncogenic role of FAM46A in ovarian cancer progression and might provide a potential clinical target for patients with chemoresistant ovarian cancer.
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- 2022
73. Laser cladding of Mg–Zn–Y–Zr alloy using Al with different ratios of micro- and nano-SiC powder
- Author
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Yueyang Liu, Wei Zhao, and Shiyou Gao
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Cladding (metalworking) ,Materials science ,Aqueous solution ,Mechanical Engineering ,Alloy ,Substrate (electronics) ,engineering.material ,Microstructure ,Mechanics of Materials ,Nano ,Volume fraction ,engineering ,General Materials Science ,Composite material ,Layer (electronics) - Abstract
In this study, a Mg–Zn–Y–Zr alloy was laser cladded with Al–SiC powder using different weight percentages and different grain sizes of SiC to improve its surface properties. We observed that the laser-cladded layer primarily comprised α-Mg, Mg2Si, Mg17Al12, Al2Y and Al3Y phases. Moreover, the cladded layer exhibited a progressive microstructure and composition, and the volume fraction and size of the Mg17Al12, Al2Y and Al3Y phases decreased with the increase in depth. Because of the formation of these hardened phases, the average hardness of the sample with 10% of nSiCp was 4.06 times that of the substrate. In comparison with four laser-cladded samples, the sample cladded with 5% of nSiCp had the lowest friction coefficient and the highest wear resistance. The potentio-dynamic polarisation curves, measured in an aqueous NaCl (3.5 wt%) solution, demonstrated that for samples with a cladding of 10% nm, the corrosion potential increased from − 1.63 V for the untreated Mg–Zn–Y–Zr alloy to − 1.32 V for the laser-cladded alloy. The corrosion current density significantly decreased from 3.60 × 10−5 to 4.03 × 10−6 A cm−2. These results demonstrate that laser cladding with nano-SiC is an effective method to significantly improve the surface properties of Mg-rare earth alloys.
- Published
- 2020
74. Saturated Attitude Control for Rigid Spacecraft Under Attitude Constraints
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Hongyang Dong, Qinglei Hu, Youmin Zhang, and Yueyang Liu
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020301 aerospace & aeronautics ,0209 industrial biotechnology ,Computer simulation ,Spacecraft ,business.industry ,Computer science ,Applied Mathematics ,Feedback control ,Physics::Physics Education ,Aerospace Engineering ,PID controller ,02 engineering and technology ,Computer Science::Computers and Society ,Attitude control ,020901 industrial engineering & automation ,0203 mechanical engineering ,Space and Planetary Science ,Control and Systems Engineering ,Control theory ,Physics::Space Physics ,Astrophysics::Earth and Planetary Astrophysics ,Electrical and Electronic Engineering ,business ,Quaternion ,Saturation (chemistry) - Abstract
This paper addresses the attitude-maneuver control problem for a rigid-body spacecraft in the presence of attitude-constrained zones as well as input saturation. More specifically, attitude-constra...
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- 2020
75. Tumor Necrosis Factor Alpha Deficiency Improves Endothelial Function and Cardiovascular Injury in Deoxycorticosterone Acetate/Salt-Hypertensive Mice
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Yang Yao, Yun Hao, Lei Huang, Ruiping Cai, Ming-Sheng Zhou, and Yueyang Liu
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Male ,0301 basic medicine ,Interleukin-1beta ,Gene Expression ,Blood Pressure ,Acetates ,Sodium Chloride ,030204 cardiovascular system & hematology ,Muscle hypertrophy ,Mice ,0302 clinical medicine ,Enos ,Endothelial dysfunction ,Desoxycorticosterone ,Aorta ,Chemokine CCL2 ,Mice, Knockout ,biology ,Heart ,General Medicine ,medicine.anatomical_structure ,Cardiovascular Diseases ,Hypertension ,NADPH Oxidase 2 ,Medicine ,Tumor necrosis factor alpha ,medicine.symptom ,Research Article ,medicine.medical_specialty ,Article Subject ,Nitric Oxide Synthase Type III ,Endothelium ,Inflammation ,General Biochemistry, Genetics and Molecular Biology ,Proinflammatory cytokine ,03 medical and health sciences ,Internal medicine ,medicine ,Animals ,RNA, Messenger ,General Immunology and Microbiology ,Tumor Necrosis Factor-alpha ,business.industry ,NADPH Oxidases ,Cytochrome b Group ,medicine.disease ,biology.organism_classification ,Mice, Inbred C57BL ,MicroRNAs ,Oxidative Stress ,030104 developmental biology ,Endocrinology ,biology.protein ,Salts ,Endothelium, Vascular ,P22phox ,business - Abstract
It has been shown that the inflammatory cytokine tumor necrosis factor α (TNFα) plays a role in the development of hypertension and end-stage renal diseases. We hypothesize that TNFα contributes to endothelial dysfunction and cardiac and vascular injury in deoxycorticosterone acetate (DOCA)/salt-hypertensive mice. The wild-type or TNFα-deficient mice were uninephrectomized and implanted with DOCA pellet treatment for 5 weeks; the mice were given either tap water or 1% NaCl drinking water. DOCA mice developed hypertension (systolic blood pressure (SBP): 167±5 vs. 110±4 mmHg in control group, p<0.05), cardiac and vascular hypertrophy, and the impairment of endothelium-dependent relaxation to acetylcholine (EDR). TNFα deficiency improved EDR and lowered cardiac and vascular hypertrophy with a mild reduction in SBP (152±4 vs. 167±5 mmHg in DOCA group, p<0.05) in DOCA mice. The mRNA expressions of the inflammatory cytokines, including TNFα, interleukin 1β (IL1β), monocyte chemotactic protein 1 (MCP1), and monocyte/macrophage marker F4/80 were significantly increased in the aorta of DOCA-hypertensive mice; TNFα deficiency reduced these inflammatory gene expressions. DOCA-hypertensive mice also exhibited an increase in the vascular oxidative fluorescence intensities, the protein expressions of gp91phox and p22phox, and the fibrotic factors transforming growth factor β and fibronectin. TNFα deficiency reduced oxidative stress and fibrotic protein expressions. The DOCA mice also showed a decrease in the protein expression of eNOS associated with increased miR155 expression; TNFα deficiency prevented a decrease in eNOS expression and an increase in miR155 expression in DOCA mice. These results support the idea that TNFα significantly contributes to vascular inflammation, vascular dysfunction, and injury in hypertension.
- Published
- 2020
76. First principles study of Schottky barriers at Ga2O3(100)/metal interfaces
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Yifei Yu, Xian Zhao, Yueyang Liu, Haoyuan Wang, Na Lin, Zhitai Jia, and Ran Xu
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010302 applied physics ,Work (thermodynamics) ,Range (particle radiation) ,Materials science ,Condensed matter physics ,General Chemical Engineering ,Schottky barrier ,Schottky diode ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Metal ,visual_art ,Fermi level pinning ,0103 physical sciences ,visual_art.visual_art_medium ,0210 nano-technology ,Wave function ,Quantum tunnelling - Abstract
A low Schottky barrier height (SBH) of metal–semiconductor contact is essential for achieving high performance electronic devices. Based on first principles calculations, we have comprehensively investigated the interfacial properties of β-Ga2O3 (100) with different metals including Mg, Ni, Cu, Pd and Pt. SBHs have been calculated via layered partial density of states (PDOS) and validated by visual wavefunctions. The results surprisingly show that Mg contact possesses the lowest SBH of 0.23 eV, while other SBHs range from 1.06 eV for Ni, 1.17 eV for Pd and 1.27 eV for Cu to 1.39 eV for Pt. This shows that SBHs of β-Ga2O3 are not fully dependent on metal work functions due to a Fermi level pinning effect. The tunneling barrier was also calculated via electrostatic potential with a 72.85% tunneling probability of the Mg/Ga2O3 interface. The present study will provide an insight into characteristics of Ga2O3/metal interfaces and give guidance for metal choice for Ga2O3 electronic devices.
- Published
- 2020
77. A magnetic field tunable Zero-Index-Metamaterial
- Author
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Yucong Yan, Yueyang Liu, Jun Qin, Longjiang Deng, Yang Li, and Lei Bi
- Abstract
We report a magnetic tunable structure consists of YIG nanorods. Applied magnetic field leading to a tunable band gap from 0 to 0.67 GHz, effective refractive index from 0 to 0+0.09i at 9 GHz frequency.
- Published
- 2022
78. A Pair of Prognostic Biomarkers in Triple-Negative Breast Cancer: KLK10 and KLK11 mRNA Expression
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Yueyang Liu, Weiwei Gong, Sarah Preis, Julia Dorn, Marion Kiechle, Ute Reuning, Viktor Magdolen, and Tobias F. Dreyer
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Article ,triple-negative breast cancer ,KLK10 ,KLK11 ,mRNA ,Space and Planetary Science ,Paleontology ,General Biochemistry, Genetics and Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,ddc - Abstract
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor patient prognosis and limited therapeutic options. A lack of prognostic biomarkers and therapeutic targets fuels the need for new approaches to tackle this severe disease. Extracellular matrix degradation, release, and modulation of the activity of growth factors/cytokines/chemokines, and the initiation of signaling pathways by extracellular proteolytic networks, have been identified as major processes in the carcinogenesis of breast cancer. Members of the kallikrein-related peptidase (KLK) family contribute to these tumor-relevant processes, and are associated with breast cancer progression and metastasis. In this study, the clinical relevance of mRNA expression of two members of this family, KLK10 and KLK11, has been evaluated in TNBC. For this, their expression levels were quantified in tumor tissue of a large, well-characterized patient cohort (n = 123) via qPCR. Although, in general, the overall expression of both factors are lower in tumor tissue of breast cancer patients (encompassing all subtypes) compared to normal tissue of healthy donors, in the TNBC subtype, expression is even increased. In our cohort, a significant, positive correlation between the expression levels of both KLKs was detected, indicating a coordinate expression mode of these proteases. Elevated KLK10 and KLK11 mRNA levels were associated with poor patient prognosis. Moreover, both factors were found to be independent of other established clinical factors such as age, lymph node status, or residual tumor mass, as determined by multivariable Cox regression analysis. Thus, both proteases, KLK10 and KLK11, may represent unfavorable prognostic factors for TNBC patients and, furthermore, appear as promising potential targets for therapy in TNBC.
- Published
- 2021
79. Agonistic analog of growth hormone–releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke
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Ruiping Cai, Fu Ren, Haotian Zhang, Yang Yao, Andrew V. Schally, Yueyang Liu, Jianhua Huang, Qian Xu, Xiaomin Su, Jingyu Yang, Ming-Sheng Zhou, Renzhi Cai, Xiaohang Che, Jialing Cai, Xiaoxiao Fu, and Xianyang Zhang
- Subjects
Male ,Agonist ,medicine.medical_specialty ,medicine.drug_class ,Neurogenesis ,Apoptosis ,Tropomyosin receptor kinase B ,Growth Hormone-Releasing Hormone ,CREB ,Neuroprotection ,Mice ,Neural Stem Cells ,Internal medicine ,medicine ,Animals ,Cyclic AMP Response Element-Binding Protein ,Protein kinase B ,Cell Proliferation ,Ischemic Stroke ,Membrane Glycoproteins ,Neuronal Plasticity ,Multidisciplinary ,biology ,business.industry ,Brain-Derived Neurotrophic Factor ,Infarction, Middle Cerebral Artery ,Recovery of Function ,Protein-Tyrosine Kinases ,Biological Sciences ,Growth hormone–releasing hormone ,Neural stem cell ,Nerve Regeneration ,Mice, Inbred C57BL ,Neuroprotective Agents ,Endocrinology ,biology.protein ,business - Abstract
Ischemic stroke can induce neurogenesis. However, most stroke-generated newborn neurons cannot survive. It has been shown that MR-409, a potent synthetic agonistic analog of growth hormone–releasing hormone (GHRH), can protect against some life-threatening pathological conditions by promoting cell proliferation and survival. The present study shows that long-term treatment with MR-409 (5 or 10 μg/mouse/d) by subcutaneous (s.c.) injection significantly reduces the mortality, ischemic insult, and hippocampal atrophy, and improves neurological functional recovery in mice operated on for transient middle cerebral artery occlusion (tMCAO). Besides, MR-409 can stimulate endogenous neurogenesis and improve the tMCAO-induced loss of neuroplasticity. MR-409 also enhances the proliferation and inhibits apoptosis of neural stem cells treated with oxygen and glucose deprivation–reperfusion. The neuroprotective effects of MR-409 are closely related to the activation of AKT/CREB and BDNF/TrkB pathways. In conclusion, the present study demonstrates that GHRH agonist MR-409 has remarkable neuroprotective effects through enhancing endogenous neurogenesis in cerebral ischemic mice.
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- 2021
80. Microscale thermophoresis and fluorescence polarization assays of calcineurin-peptide interactions
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Nan Zhang, Yueyang Liu, Xiaoyu Shi, Yuchen Zhang, Wenying Li, Yumeng Yang, Limin Chen, Yanxia Yin, Li Tong, Jingyu Yang, and Jing Luo
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Calmodulin ,Calcineurin ,Amino Acid Motifs ,Biophysics ,Fluorescence Polarization ,Cell Biology ,Molecular Biology ,Biochemistry ,Protein Binding - Abstract
Calcineurin is a Ca
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- 2021
81. Advancing biomass pyrolysis by torrefaction pretreatment: Linking the productions of bio-oil and oxygenated chemicals to torrefaction severity
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Dongyu Chen, Jin Li, Ting Zhang, Shun Li, Jing Wang, Weisheng Niu, Yueyang Liu, Anqing Zheng, and Zengli Zhao
- Subjects
Fuel Technology ,General Chemical Engineering ,Organic Chemistry ,Energy Engineering and Power Technology - Published
- 2022
82. Wnt5a regulates autophagy in Bacille Calmette-Guérin (BCG)-Infected pulmonary epithelial cells
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Qi Chen, Xuedi Zheng, Yong Li, Boli Ma, Xueyi Nie, Mengyuan Li, Yueyang Liu, Jinrui Xu, and Yi Yang
- Subjects
History ,Polymers and Plastics ,TOR Serine-Threonine Kinases ,Epithelial Cells ,Mycobacterium tuberculosis ,Microbiology ,Industrial and Manufacturing Engineering ,Mice ,Infectious Diseases ,Autophagy ,BCG Vaccine ,Animals ,Tuberculosis ,Business and International Management ,Wnt Signaling Pathway - Abstract
Autophagy functions as a critical process that can suppress the proliferation of Mycobacterium tuberculosis (Mtb) within infected host cells. Wnt5a is a secreted protein that plays a range of physiological functions, activating several signaling pathways and thereby controlling cellular responses to particular stimuli. The importance of Wnt5a as a regulator of protection against Mtb infection, however, has yet to be fully characterized. Here, changes in murine pulmonary epithelial-like TC-1 cell morphology, autophagy, the Wnt/Ca
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- 2022
83. N-buffer design and optimization in 4500V class IGBT
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Ruifen Nie, Rui Jin, Yaohua Wang, Li Li, Mingchao Gao, Yueyang Liu, Feng He, Jiang Liu, Cui Li, Wanru Sun, and Baohua Tian
- Subjects
History ,Computer Science Applications ,Education - Abstract
In this paper, the effects of doping structure of multi-proton injection (MPI) buffer layer on static and short circuit characteristics of IGBT were studied, and the relationship between donor concentration of the buffer layer and injection dose and annealing temperature was studied. The MPI buffer layer suitable for 4500V IGBT was optimized by comparative experiments. This MPI buffer layer can solve the problem of high-temperature activation of the traditional IGBT buffer layer and lower thermal budget and can be fabricated on large wafers for better parameter consistency.
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- 2022
84. Saturated attitude control for rigid body under input delay and pointing constraints
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Yiqi Xu, Yueyang Liu, and Qinglei Hu
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Aerospace Engineering - Published
- 2022
85. Epileptic seizure onset predicts its duration
- Author
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Zhinoos Razavi Hesabi, Mark J. Cook, Levin Kuhlmann, and Yueyang Liu
- Subjects
medicine.medical_specialty ,Epilepsy ,business.industry ,Electroencephalography ,Status epilepticus ,Audiology ,medicine.disease ,Intracranial Electroencephalography ,Seizure onset ,Neurology ,ROC Curve ,Duration (music) ,Seizures ,Recurrent seizures ,Seizure control ,medicine ,Humans ,Epilepsy, Generalized ,Neurology (clinical) ,Epileptic seizure ,medicine.symptom ,business - Abstract
Epilepsy is characterized by recurrent seizures that have a variety of manifestations. The severity of, and risks for patients associated with, seizures are largely linked to the duration of seizures. Methods that determine seizure duration based on seizure onsets could be used to help mitigate the risks associated with what might be extended seizures by guiding timely interventions.Using long-term intracranial electroencephalography (iEEG) recordings, this article presents a method for predicting whether a seizure is going to be long or short by analyzing the seizure onset. The definition of long and short depends on each patient's seizure distribution. By analyzing 2954 seizures from 10 patients, patient-specific classifiers were built to predict seizure duration given the first few seconds from the onset.The proposed methodology achieved an average area under the receiver operating characteristic curve (AUC) performance of 0.7 for the 5 of 10 patients with above chance prediction performance (p value from 0.04 to 10Our results imply that the duration of seizures can be predicted from the onset in some patients. This could form the basis of methods for predicting status epilepticus or optimizing the amount of electrical stimulation delivered by seizure control devices.
- Published
- 2021
86. Activation of Yes-Associated Protein/PDZ-Binding Motif Pathway Contributes to Endothelial Dysfunction and Vascular Inflammation in AngiotensinII Hypertension
- Author
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Xiaomin Su, Kunping Zhuo, Ming-Sheng Zhou, Lin Zhu, Lu Zhang, Ruiping Cai, Yueyang Liu, Fu Ren, and Qian Xu
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medicine.medical_specialty ,Hippo signaling pathway ,hypertension ,Chemistry ,Physiology ,Hippo/YAP pathway ,Protein phosphatase 2 ,medicine.disease ,Umbilical vein ,endothelial dysfunction ,Proinflammatory cytokine ,Endocrinology ,angiotensinII ,Physiology (medical) ,Internal medicine ,Coactivator ,Renin–angiotensin system ,medicine ,vascular inflammation ,QP1-981 ,Endothelial dysfunction ,Signal transduction ,Original Research - Abstract
Yes-associated protein (YAP) and its associated coactivator of PDZ-binding motif (TAZ) are co-transcriptional regulators and down effectors of the Hippo signaling pathway. Recent studies have shown that the Hippo/YAP signaling pathway may play a role in mediating vascular homeostasis. This study investigated the role of YAP/TAZ in endothelial dysfunction and vascular inflammation in angiotensin (Ang)II hypertensive mice. The infusion of AngII (1.1 mg/kg/day by mini-pump) for 3 weeks induced the activation of YAP/TAZ, manifested by decreased cytosolic phosphor-YAP and phosphor-TAZ, and increased YAP/TAZ nuclear translocation, which were prevented by YAP/TAZ inhibitor verteporfin. AngII significantly increased systolic blood pressure (SBP), macrophage infiltration, and expressions of proinflammatory cytokines, and impaired endothelial function in the aorta of the mice. Treatment with verteporfin improved endothelial function and reduced vascular inflammation with a mild reduction in SBP. AngII also induced YAP/TAZ activation in human umbilical vein endothelial cells in vitro, which were prevented by LB-100, an inhibitor of protein phosphatase 2A (PP2A, a major dephosphorylase). Treatment with LB-100 reversed AngII-induced proinflammatory cytokine expression and impairment of phosphor-eNOS expression in vitro. Our results suggest that AngII induces YAP/TAZ activation via PP2A-dependent dephosphorylation, which may contribute to the impairment of endothelial function and the induction of vascular inflammation in hypertension. YAP/TAZ may be a new target for hypertensive vascular injury.
- Published
- 2021
87. Integrated Tissue and Blood miRNA Expression Profiles Identify Novel Biomarkers for Accurate Non-Invasive Diagnosis of Breast Cancer: Preliminary Results and Future Clinical Implications
- Author
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Fei Su, Ziyu Gao, Yueyang Liu, Guiqin Zhou, Ying Cui, Chao Deng, Yuyu Liu, Yihao Zhang, Xiaoyan Ma, Yongxia Wang, Lili Guan, Yafang Zhang, and Baoquan Liu
- Subjects
MicroRNAs ,Carcinogenesis ,Genetics ,tissue ,blood ,breast cancer ,primary synergy miRNA ,diagnostic marker ,Humans ,Female ,Breast Neoplasms ,Prognosis ,Biomarkers ,Genetics (clinical) - Abstract
We aimed to identify miRNAs that were closely related to breast cancer (BRCA). By integrating several methods including significance analysis of microarrays, fold change, Pearson’s correlation analysis, t test, and receiver operating characteristic analysis, we developed a decision-tree-based scoring algorithm, called Optimized Scoring Mechanism for Primary Synergy MicroRNAs (O-PSM). Five synergy miRNAs (hsa-miR-139-5p, hsa-miR-331-3p, hsa-miR-342-5p, hsa-miR-486-5p, and hsa-miR-654-3p) were identified using O-PSM, which were used to distinguish normal samples from pathological ones, and showed good results in blood data and in multiple sets of tissue data. These five miRNAs showed accurate categorization efficiency in BRCA typing and staging and had better categorization efficiency than experimentally verified miRNAs. In the Protein-Protein Interaction (PPI) network, the target genes of hsa-miR-342-5p have the most regulatory relationships, which regulate carcinogenesis proliferation and metastasis by regulating Glycosaminoglycan biosynthesis and the Rap1 signaling pathway. Moreover, hsa-miR-342-5p showed potential clinical application in survival analysis. We also used O-PSM to generate an R package uploaded on github (SuFei-lab/OPSM accessed on 22 October 2021). We believe that miRNAs included in O-PSM could have clinical implications for diagnosis, prognostic stratification and treatment of BRCA, proposing potential significant biomarkers that could be utilized to design personalized treatment plans in BRCA patients in the future.
- Published
- 2022
88. Torque-Limited Attitude Control for Rigid Spacecraft with Motion Constraints
- Author
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Yueyang Liu, Qinglei Hu, and Zhining Bai
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Attitude control ,Maxima and minima ,Lyapunov function ,symbols.namesake ,Computer science ,Control theory ,Saddle point ,Convergence (routing) ,symbols ,Torque ,Function (mathematics) - Abstract
A continuous saturated attitude control scheme is proposed that meets the control object of reorientation and attitude forbidden zone avoidance. Constructed from the classical potential-function-based control methodology, the derived controller can achieve uniformly ultimate boundedness without the obstruction of local minima or saddle points of the potential function. Specifically, the properties of derived potential are analyzed meticulously. Moreover, an explicit controllable domain is integrated into certain inequalities featuring initial states and control parameters to describe the capability of avoidance. The control performance can be also estimated and adjusted by tuning control parameters. A Lyapunov-based analysis is provided to show the convergence of the potential function, the gradient of the potential function and the closed-loop system. Furthermore, simulations are performed to demonstrate the effectiveness and features of the control law.
- Published
- 2021
89. Line-of-sight Tracking Control Scheme for Integrated Satellite with CMGs Vibration Isolation Platform
- Author
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Lei Jin, Huanjie Wang, Qinglei Hu, Fei Pan, Han Wu, and Yueyang Liu
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Vibration ,Vibration isolation ,Control theory ,law ,Rotor (electric) ,Computer science ,Trajectory ,Gyroscope ,Satellite system ,Time domain ,law.invention - Abstract
This paper proposes an overall design scheme of Line-of-sight (LOS) tracking control for the integrated satellite system with vibration isolation platform (VIP) and control moment gyroscopes (CMGs). First, the three-axis attitude and motion trajectory are established for tracking the on-orbit dynamic target. To improve the accuracy and stability of target tracking, the VIP is applied to isolate CMGs micro vibration, and then controller parameters of integrated satellite system are synthetically designed based on the classical control theory. Subsequently, the effectiveness of the control scheme is verified by frequency and time domain simulation. The numerical examples show that the tracking accuracy can be increased by 80% and the stability can be improved by two orders of magnitude after adding VIP in the presence of the sample time of controller and the rotor static and dynamic imbalance.
- Published
- 2021
90. Neuroprotective effect of pseudoginsenoside-F11 on permanent cerebral ischemia in rats by regulating calpain activity and NR2A submit-mediated AKT-CREB signaling pathways
- Author
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Peirui Cui, Huiyang Wang, Saiqian Wang, Haotian Zhang, Liting Liu, Yueyang Liu, Zongjuan Hou, Yang Zhao, Chunfu Wu, Zinv Zhang, Xiaoxiao Fu, Tianyu Zhang, Yuhuan Liu, and Jingyu Yang
- Subjects
Ginsenosides ,Ischemia ,Pharmaceutical Science ,Pharmacology ,CREB ,Neuroprotection ,Receptors, N-Methyl-D-Aspartate ,Brain Ischemia ,Downregulation and upregulation ,In vivo ,parasitic diseases ,Drug Discovery ,medicine ,Animals ,Stroke ,Protein kinase B ,biology ,business.industry ,Calpain ,medicine.disease ,Rats ,Neuroprotective Agents ,nervous system ,Complementary and alternative medicine ,biology.protein ,Molecular Medicine ,Signal transduction ,business ,Proto-Oncogene Proteins c-akt ,Signal Transduction - Abstract
Background N-methyl-d-aspartate receptors (NMDARs) have been demonstrated to play central roles in stroke pathology and recovery, including dual roles in promoting either neuronal survival or death with their different subtypes and locations. Purpose We have previously demonstrated that pseudoginsenoside-F11 (PF11) can provide long-term neuroprotective effects on transient and permanent ischemic stroke-induced neuronal damage. However, it is still needed to clarify whether NMDAR-2A (NR2A)-mediated pro-survival signaling pathway is involved in the beneficial effect of PF11 on permanent ischemic stroke. Material and Methods PF11 was administrated in permanent middle cerebral artery occlusion (pMCAO)-operated rats. The effect of PF11 on oxygen-glucose deprivation (OGD)-exposed primary cultured neurons were further evaluated. The regulatory effect of PF11 on NR2A expression and the activation of its downstream AKT-CREB pathway were detected by Western blotting and immunofluorescence in the presence or absence of a specific NR2A antagonist NVP-AAM077 (NVP) both in vivo and in vitro. Results PF11 dose- and time-dependently decreased calpain1 (CAPN1) activity and its specific breakdown product α-Fodrin expression, while the expression of Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII-α) was significantly upregulated in the cortex and striatum of rats at 24 h after the onset of pMCAO operation. Moreover, PF11 prevented the downregulation of NR2A, p-AKT/AKT, and p-CREB/CREB in both in vivo and in vitro stroke models. Finally, the results indicated treatment with NVP can abolish the effects of PF11 on alleviating the ischemic injury and activating NR2A-mediated AKT-CREB signaling pathway. Conclusions Our results demonstrate that PF11 can exert neuroprotective effects on ischemic stroke by inhibiting the activation of CAPN1 and subsequently enhancing the NR2A-medicated activation of AKT-CREB pathway, which provides a mechanistic link between the neuroprotective effect of PF11 against cerebral ischemia and NR2A-associated pro-survival signaling pathway.
- Published
- 2021
91. Macrophage depletion protects against endothelial dysfunction and cardiac remodeling in angiotensin II hypertensive mice
- Author
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Qian Xu, Yuantong Tian, Jun Luo, Yueyang Liu, Ming-Sheng Zhou, and Ruiping Cai
- Subjects
medicine.medical_specialty ,Physiology ,030204 cardiovascular system & hematology ,Systemic inflammation ,Proinflammatory cytokine ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Fibrosis ,medicine.artery ,Internal medicine ,Renin–angiotensin system ,Internal Medicine ,medicine ,Animals ,030212 general & internal medicine ,Endothelial dysfunction ,Ventricular remodeling ,Aorta ,Ventricular Remodeling ,business.industry ,Angiotensin II ,Macrophages ,Myocardium ,General Medicine ,medicine.disease ,Mice, Inbred C57BL ,Endocrinology ,Hypertension ,cardiovascular system ,medicine.symptom ,business - Abstract
Objective: Hypertension is associated with a low-grade systemic inflammation in cardiovascular system. Macrophage infiltration may initiate an inflammatory process that contributes to vascular and ventricular remodeling in hypertensive human and mice. The present study investigated the effect of chemical depletion of macrophage using liposome encapsulated clodronate (LEC) on cardiac hypertrophy and remodeling in angiotensin (Ang) II hypertensive mice.Methods: C57BL/6 mice received an Ang II (1.1 mg/kg/day with a minipump) infusion for 2 weeks to induce hypertension. Endothelium-dependent relaxation (ED) was examined by organ bath, hematoxylin and staining and Masson-Trichrome staining were used to evaluate aorta and cardiac hypertrophy and fibrosis.Results: Ang II infusion significantly increased systolic blood pressure (SBP), cardiac hypertrophy and fibrosis, and impaired EDR accompanied by increased macrophage infiltration in the heart. Treatment with LEC significantly lowered Ang II-induced cardiac hypertrophy and fibrosis and cardiac macrophage infiltration, and improved EDR with a mild reduction in SBP. Ang II increased the expression of inflammatory cytokines tumor necross factor alpha and interleukin 1 beta and profibrotic factors transforming growth factor beta 1 and fibronectin in the heart, with was reduced by LEC treatment. Treatment with LEC prevented Ang II-induced the phosphorphorylation of ERK1/2 and c-Jun-N-terminal kinase.Conclusions: Our study suggests that cardiac macrophage may be critical for hypertensive cardiac hypertrophy and remodeling, the underlying mechanisms may involve initial heart inflammation and the activation of hypertrophic MAPKs pathway.
- Published
- 2021
92. Adaptive Pose Tracking Control for Spacecraft Proximity Operations Under Motion Constraints
- Author
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Maruthi R. Akella, Yueyang Liu, Hongyang Dong, and Qinglei Hu
- Subjects
020301 aerospace & aeronautics ,0209 industrial biotechnology ,Adaptive control ,Computer simulation ,Spacecraft ,business.industry ,Computer science ,Applied Mathematics ,Control (management) ,Aerospace Engineering ,02 engineering and technology ,Motion (physics) ,Model predictive control ,020901 industrial engineering & automation ,0203 mechanical engineering ,Space and Planetary Science ,Control and Systems Engineering ,Control theory ,Electrical and Electronic Engineering ,business ,Quaternion ,Pose tracking - Abstract
A novel adaptive control solution for pose tracking problems of spacecraft proximity operations subject to not only motion constraints but also parameter uncertainties is proposed in this paper. Sp...
- Published
- 2019
93. Effect of gasifying agents on sawdust gasification in a novel pilot scale bubbling fluidized bed system
- Author
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Yueyang Liu, Donghai Wang, Fanbin Meng, Hongde Wang, and Qingbang Ma
- Subjects
Materials science ,020209 energy ,General Chemical Engineering ,Organic Chemistry ,Energy conversion efficiency ,food and beverages ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Producer gas ,02 engineering and technology ,Pulp and paper industry ,complex mixtures ,Water-gas shift reaction ,Dilution ,Fuel Technology ,020401 chemical engineering ,chemistry ,Yield (chemistry) ,visual_art ,0202 electrical engineering, electronic engineering, information engineering ,visual_art.visual_art_medium ,Heat of combustion ,Sawdust ,0204 chemical engineering ,Carbon - Abstract
Effect of gasifying agents, such as air, oxygen-enriched air, air-steam, and oxygen-steam, on sawdust gasification was investigated in a novel pilot scale bubbling fluidized bed gasification system. The results showed that gasifying agents had a significant effect on gasification performance and producer gas properties. H2 content in the producer gas increased as equivalence ratio (ER) increased from 0.20 to 0.30 for all gasifying agents used. CO, CH4, and CnHm decreased and CO2 presented two different trends as ER increased from 0.20 to 0.30, resulting in lower heating value decreasing, gas yield increasing, carbon conversion efficiency and cold gas efficiency change. Compared to sawdust gasification using air only, oxygen-enriched air increased lower heating value due to reducing N2 dilution, air-steam favored H2 production because of enhancing water gas shift reaction, and oxygen-steam took both advantages of N2 free and steam addition. The maximum value of the H2/CO ratio was 1.44 by using air-steam and oxygen-steam as the gasifying agents at the ER of 0.30.
- Published
- 2019
94. Pseudoginsenoside-F11 Protects against Transient Cerebral Ischemia Injury in Rats Involving Repressing Calcium Overload
- Author
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Hanlin Yang, Yueyang Liu, Xiaowei Yang, Chunfu Wu, Shibo Sun, Linlin Yuan, Yinglu Liu, Tianyu Zhang, and Jingyu Yang
- Subjects
0301 basic medicine ,Ginsenosides ,Neurite ,Pseudoginsenoside F11 ,Sarcoplasm ,Ischemia ,Brain Edema ,Pharmacology ,Neuroprotection ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,parasitic diseases ,medicine ,Animals ,Stroke ,Neurons ,Cell Death ,Chemistry ,General Neuroscience ,Endoplasmic reticulum ,Brain ,medicine.disease ,Rats ,Disease Models, Animal ,Neuroprotective Agents ,030104 developmental biology ,Ischemic Attack, Transient ,Calcium ,030217 neurology & neurosurgery - Abstract
Calcium overload has been reported to trigger neuronal death following stroke. Pseudoginsenoside-F11 (PF11), an ocotillol-type ginsenoside with various neuroprotective activities, has displayed therapeutic efficacy against permanent ischemic stroke. The present study examined the protective potential of PF11 in rats subjected to 2-h transient middle cerebral artery occlusion (tMCAO) and in cultured primary cortical neuron (PCN) exposed to oxygen–glucose deprivation/reoxygenation (OGD/R). Single intravenous administration of PF11 (12 mg/kg) significantly reduced infarct volume, brain edema, neurological deficit and cortex neuron loss at 24 h after reperfusion. Immunoblotting and immunofluorescence demonstrated that PF11 inhibited the over activation of μ-Calpain and the reduction of calcium calmodulin kinase II-α, reduced the degradation of sarcoplasmic/endoplasmic reticulum ATPase-2 and alleviated endoplasmic reticulum stress (ERS) in tMCAO rats. What's more, rats treated with PF11 (12 mg/kg) intravenously immediately after reperfusion, and then intraperitoneally every 24 h for 14 days exhibited lessened cortex neuron loss, reduced mortality and improved performances of rotarod, grip strength and gait patterns at 1, 4, 7, and 14 days after tMCAO. Furthermore, in vitro investigations showed PF11 increased cell viability, reduced neurites decline, restored ATP level and decreased calcium content in cultured PCN under OGD/R. Moreover, PF11 alleviated ERS, reversed the diminished levels of NMDA-2B subunit, postsynaptic density protein 95 and neuronal nitric oxide synthase both in vivo and in vitro. Our study indicates that PF11 produced neuroprotection and improved long-term outcomes while repressing calcium overload in model of transient focal ischemia, suggesting that PF11 might be a considerable candidate for stroke treatment.
- Published
- 2019
95. Control of non-cooperative spacecraft in final phase proximity operations under input constraints
- Author
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Youmin Zhang, Yueyang Liu, and Qinglei Hu
- Subjects
Lyapunov function ,0209 industrial biotechnology ,Spacecraft ,Computer science ,business.industry ,Applied Mathematics ,020208 electrical & electronic engineering ,Pursuer ,02 engineering and technology ,Function (mathematics) ,Tracking (particle physics) ,Computer Science Applications ,symbols.namesake ,020901 industrial engineering & automation ,Control and Systems Engineering ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,Trajectory ,symbols ,Electrical and Electronic Engineering ,Actuator ,business - Abstract
This paper addresses the approaching trajectory control problem for the final phase of non-cooperative spacecraft proximity operations in the presence of disturbances and even input saturation. As a stepping stone, a novel line-of-sight tracking model is developed to describe attitude maneuver towards the target in the proximity. Then, a two-stage artificial potential function is employed to enable the pursuer spacecraft to comply the safety trajectory during approaching the target. In each stage, gradients of potential function are analyzed and the local minimum problem associated with potential function can be addressed. Furthermore, a saturated control law is proposed to ensure a reliable real-time tracking measurement of the target, and the controller rigorously enforces safe path and actuator magnitude constraints. The associated stability proof is accomplished through Lyapunov method. Simulations are carried out to evaluate the effectiveness of the proposed method.
- Published
- 2019
96. CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage
- Author
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Xiaoxiao Fu, Yu Yang, Jun Luo, Haotian Zhang, Jingyu Yang, Che Xiaohang, Ruiping Cai, Xiangnan Yu, Ming-Sheng Zhou, Yueyang Liu, and Yang Yao
- Subjects
0301 basic medicine ,Male ,Ischemia ,Autophagy-Related Protein 5 ,Brain Ischemia ,Rats, Sprague-Dawley ,03 medical and health sciences ,Phosphatidylinositol 3-Kinases ,0302 clinical medicine ,Neuronal damage ,medicine ,Autophagy ,Animals ,Phosphoinositide-3 Kinase Inhibitors ,Advanced and Specialized Nursing ,Neurons ,business.industry ,Calpain ,Adenine ,Infarction, Middle Cerebral Artery ,Dipeptides ,medicine.disease ,Cell biology ,Rats ,Disease Models, Animal ,030104 developmental biology ,Beclin-1 ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Flux (metabolism) ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
Background and Purpose: CAPN1 (calpain1)—an intracellular Ca 2+ -regulated cysteine protease—can be activated under cerebral ischemia. However, the mechanisms by which CAPN1 activation promotes cerebral ischemic injury are not defined. Methods: In the present study, we used adeno-associated virus-mediated genetic knockdown and pharmacological blockade (MDL-28170) of CAPN1 to investigate the role of CAPN1 in the regulation of the autophagy-lysosomal pathway and neuronal damage in 2 models, rat permanent middle cerebral occlusion in vivo model and oxygen-glucose–deprived primary neuron in vitro model. Results: CAPN1 was activated in the cortex of permanent middle cerebral occlusion–operated rats and oxygen-glucose deprivation–exposed neurons. Genetic and pharmacological inhibition of CAPN1 significantly attenuated ischemia-induced lysosomal membrane permeabilization and subsequent accumulation of autophagic substrates in vivo and in vitro. Moreover, inhibition of CAPN1 increased autophagosome formation by decreasing the cleavage of the autophagy regulators BECN1 (Beclin1) and ATG (autophagy-related gene) 5. Importantly, the neuron-protective effect of MDL-28170 on ischemic insult was reversed by cotreatment with either class III-PI3K (phosphatidylinositol 3-kinase) inhibitor 3-methyladenine or lysosomal inhibitor chloroquine (chloroquine), suggesting that CAPN1 activation-mediated impairment of autophagic flux is crucial for cerebral ischemia-induced neuronal damage. Conclusions: The present study demonstrates for the first time that ischemia-induced CAPN1 activation impairs lysosomal function and suppresses autophagosome formation, which contribute to the accumulation of substrates and aggravate the ischemia-induced neuronal cell damage. Our work highlights the vital role of CAPN1 in the regulation of cerebral ischemia–mediated autophagy-lysosomal pathway defects and neuronal damage.
- Published
- 2021
97. Ultra-low-loss on-chip zero-index materials
- Author
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Weiguo Chu, Peipei Chen, Sarah Alejandra Camayd-Muñoz, Yang Li, Xiaojun Wu, Haoning Tang, Jiujiu Liang, Yueyang Liu, Tian Dong, Eric Mazur, and Shota Kita
- Subjects
Materials science ,Silicon ,Physics::Optics ,chemistry.chemical_element ,02 engineering and technology ,01 natural sciences ,Article ,law.invention ,010309 optics ,Photonic crystals ,Optics ,law ,0103 physical sciences ,Applied optics. Photonics ,Planar process ,Quantum optics ,Nanophotonics and plasmonics ,business.industry ,Superradiance ,QC350-467 ,Optics. Light ,021001 nanoscience & nanotechnology ,Laser ,Atomic and Molecular Physics, and Optics ,TA1501-1820 ,Electronic, Optical and Magnetic Materials ,Coherence length ,chemistry ,Metamaterials ,0210 nano-technology ,business ,Refractive index ,Coherence (physics) - Abstract
Light travels in a zero-index medium without accumulating a spatial phase, resulting in perfect spatial coherence. Such coherence brings several potential applications, including arbitrarily shaped waveguides, phase-mismatch-free nonlinear propagation, large-area single-mode lasers, and extended superradiance. A promising platform to achieve these applications is an integrated Dirac-cone material that features an impedance-matched zero index. Although an integrated Dirac-cone material eliminates ohmic losses via its purely dielectric structure, it still entails out-of-plane radiation loss, limiting its applications to a small scale. We design an ultra-low-loss integrated Dirac cone material by achieving destructive interference above and below the material. The material consists of a square array of low-aspect-ratio silicon pillars embedded in silicon dioxide, featuring easy fabrication using a standard planar process. This design paves the way for leveraging the perfect spatial coherence of large-area zero-index materials in linear, nonlinear, and quantum optics., Zero-index media: ultra-low loss Calculations suggest that a new design of engineered medium can simultaneously yield a refractive index of zero and low optical loss at the telecommunications wavelength of 1550 nm. The development could lead to applications in nonlinear and quantum optics benefiting from an infinite coherence length. The approach of Tian Dong and coworkers from China and the US is to embed an array of silicon pillars (about 180 nm in radius and 1100 nm high) into a matrix of silicon dioxide to create a Dirac-cone photonic-crystal slab. Importantly, if the pillar height is chosen correctly any upwards and downwards radiation out of the slab can be made to destructively interfere thus reducing propagation loss to a level of 0.15 dB/mm. The slab should be possible to fabricate using standard processes.
- Published
- 2021
98. A Semi-supervised Framework for Misinformation Detection
- Author
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Nathalie Japkowicz, Yueyang Liu, and Zois Boukouvalas
- Subjects
Class (computer programming) ,Computer science ,Test data generation ,business.industry ,Semi-supervised learning ,Machine learning ,computer.software_genre ,Order (exchange) ,Classifier (linguistics) ,Social media ,Misinformation ,Artificial intelligence ,business ,computer ,Simple (philosophy) - Abstract
The spread of misinformation in social media outlets has become a prevalent societal problem and is the cause of many kinds of social unrest. Curtailing its prevalence is of great importance and machine learning has shown significant promise. However, there are two main challenges when applying machine learning to this problem. First, while much too prevalent in one respect, misinformation, actually, represents only a minor proportion of all the postings seen on social media. Second, labeling the massive amount of data necessary to train a useful classifier becomes impractical. Considering these challenges, we propose a simple semi-supervised learning framework in order to deal with extreme class imbalances that has the advantage, over other approaches, of using actual rather than simulated data to inflate the minority class. We tested our framework on two sets of Covid-related Twitter data and obtained significant improvement in F1-measure on extremely imbalanced scenarios, as compared to simple classical and deep-learning data generation methods such as SMOTE, ADASYN, or GAN-based data generation.
- Published
- 2021
99. Pseudoginsenoside F11 ameliorates the dysfunction of the autophagy-lysosomal pathway by activating calcineurin-mediated TFEB nuclear translocation in neuron during permanent cerebral ischemia
- Author
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Jingyu Yang, Chunfu Wu, Xiangnan Yu, Yueyang Liu, Xiaoxiao Fu, Haonan Zhang, and Xuemei Wang
- Subjects
0301 basic medicine ,Male ,Ginsenosides ,Phosphatase ,Chromosomal translocation ,Neuroprotection ,Brain Ischemia ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Developmental Neuroscience ,Lysosome ,parasitic diseases ,medicine ,Autophagy ,Animals ,Cell Nucleus ,Neurons ,Chemistry ,Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ,Calcineurin ,Cell biology ,Rats ,Protein Transport ,030104 developmental biology ,medicine.anatomical_structure ,Neuroprotective Agents ,Neurology ,TFEB ,Neuron ,Lysosomes ,030217 neurology & neurosurgery - Abstract
We have previously found that transcription factor EB (TFEB), as a master regulator of autophagy and lysosome biogenesis, provides neuroprotective effects on cerebral ischemia-induced neuronal damage by activation of autophagy-lysosomal pathway (ALP). We have also reported that Pseudoginsenoside F11 (PF11), an ocotillol-type saponin isolated from Panax quinquefolium L., significantly attenuates the ischemic injury of rats subjected to permanent middle cerebral artery occlusion (pMCAO), possibly by alleviating the autophagic/lysosomal defects. The present study aims to investigate whether the beneficial effect of PF11 on ALP dysfunction induced by permanent ischemic stroke is based on its regulation of TFEB nuclear translocation in pMCAO rats and the oxygen-glucose-deprived (OGD) primary neurons. Meanwhile, the role of calcineurin, a serine/threonine protein phosphatase, during this process in which PF11 regulated TFEB transcriptional activity was also explored. The data showed that PF11 exerted significant protective effects on pMCAO-induced injury and decreased OGD-induced neuronal death. The nuclear localization of TFEB was decreased at 24 h after pMCAO. Notably, PF11 (6, 12 mg/kg, i.v.) significantly increased TFEB nuclear expression and Tfeb mRNA level at 24 h following pMCAO. OGD treatment promoted TFEB aggregation and nuclear translocation until 6 h, and the nuclear localization of TFEB was decreased at 12 h. Similarly, PF11 (30, 100 μM) could also promote the translocation of TFEB into nuclear in primary neurons at 12 h after OGD treatment. Moreover, PF11 attenuated OGD-induced lysosomal dysfunction and abnormal accumulation of autophagosomes and substrates. These in vitro effects could be abolished by neuronal-specific knocking down of TFEB via transfecting primary neurons with lentivirus encoding shTfeb. Further studies indicated that cyclosporine (10 μM), an inhibitor of calcineurin, could significantly diminish the effects of PF11 on TFEB nuclear translocation and ALP dysfunction in OGD-treated neurons. In summary, these results demonstrate that PF11 attenuates the dysfunction of ALP in permanent cerebral ischemia by promoting the calcineurin-mediated nuclear translocation of TFEB and further identifies an autophagic mechanism of PF11 against cerebral ischemia.
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- 2020
100. Additional file 2 of Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer
- Author
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Weiwei Gong, Yueyang Liu, Diamandis, Eleftherios P., Kiechle, Marion, Bronger, Holger, Dorn, Julia, Dreyer, Tobias, and Magdolen, Viktor
- Abstract
Additional file 2. Validation of a significant association between KLK7 mRNA expression and progression-free survival of patients using publicly available Affymetrix data. For analysis of the prognostic value of KLK7 mRNA expression, the online tool Kaplan-Meier Plotter - Ovarian Cancer [53] was used (probe ID: 239381_at; data set 2015 [n = 1648]) applying the following selection criteria for the patients: (i) serous histological type, (ii) advanced stage (FIGO III/IV), (iii) chemotherapy using platinum compounds, and (iv) a follow-up of 5 years. Kaplan-Meier analysis confirmed that elevated KLK7 mRNA is significantly correlated with a shortened PFS (p = 0.034). With regard to OS, no significant correlation with KLK7 mRNA expression was observed.
- Published
- 2020
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