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866 results on '"Yuan, Ti-Fei"'

55. Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Author

Ekhtiari, Hamed, Tavakoli, Hosna, Addolorato, Giovanni, Baeken, Chris, Bonci, Antonello, Campanella, Salvatore, Castelo-Branco, Luis, Challet-Bouju, Gaëlle, Clark, Vincent P., Claus, Eric, Dannon, Pinhas N., Del Felice, Alessandra, den Uyl, Tess, Diana, Marco, di Giannantonio, Massimo, Fedota, John R., Fitzgerald, Paul, Gallimberti, Luigi, Grall-Bronnec, Marie, Herremans, Sarah C., Herrmann, Martin J., Jamil, Asif, Khedr, Eman, Kouimtsidis, Christos, Kozak, Karolina, Krupitsky, Evgeny, Lamm, Claus, Lechner, William V., Madeo, Graziella, Malmir, Nastaran, Martinotti, Giovanni, McDonald, William M., Montemitro, Chiara, Nakamura-Palacios, Ester M., Nasehi, Mohammad, Noël, Xavier, Nosratabadi, Masoud, Paulus, Martin, Pettorruso, Mauro, Pradhan, Basant, Praharaj, Samir K., Rafferty, Haley, Sahlem, Gregory, Salmeron, Betty jo, Sauvaget, Anne, Schluter, Renée S., Sergiou, Carmen, Shahbabaie, Alireza, Sheffer, Christine, Spagnolo, Primavera A., Steele, Vaughn R., Yuan, Ti-fei, van Dongen, Josanne D.M., Van Waes, Vincent, Venkatasubramanian, Ganesan, Verdejo-García, Antonio, Verveer, Ilse, Welsh, Justine W., Wesley, Michael J., Witkiewitz, Katie, Yavari, Fatemeh, Zarrindast, Mohammad-Reza, Zawertailo, Laurie, Zhang, Xiaochu, Cha, Yoon-Hee, George, Tony P., Frohlich, Flavio, Goudriaan, Anna E., Fecteau, Shirley, Daughters, Stacey B., Stein, Elliot A., Fregni, Felipe, Nitsche, Michael A., Zangen, Abraham, Bikson, Marom, and Hanlon, Colleen A.

Published
2019
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61. The Eph receptor A4 plays a role in demyelination and depression-related behavior

Author

Li, Yuan, Su, Ping, Chen, Yuxiang, Nie, Jing, Yuan, Ti-Fei, Wong, Albert H.C., and Liu, Fang

Subjects
Depression, Mental -- Development and progression, Demyelinating diseases -- Development and progression, Myelin proteins -- Health aspects, Protein tyrosine kinase -- Health aspects, Health care industry
Abstract

Proper myelination of axons is crucial for normal sensory, motor, and cognitive function. Abnormal myelination is seen in brain disorders such as major depressive disorder (MDD), but the molecular mechanisms connecting demyelination with the pathobiology remain largely unknown. We observed demyelination and synaptic deficits in mice exposed to either chronic, unpredictable mild stress (CUMS) or LPS, 2 paradigms for inducing depression-like states. Pharmacological restoration of myelination normalized both synaptic deficits and depression-related behaviors. Furthermore, we found increased ephrin A4 receptor (EphA4) expression in the excitatory neurons of mice subjected to CUMS, and shRNA knockdown of EphA4 prevented demyelination and depression-like behaviors. These animal data are consistent with the decrease in myelin basic protein and the increase in EphA4 levels we observed in postmortem brain samples from patients with MDD. Our results provide insights into the etiology of depressive symptoms in some patients and suggest that inhibition of EphA4 or the promotion of myelination could be a promising strategy for treating depression., Introduction Major depressive disorder (MDD) is a very common and severe psychiatric disorder that affects approximately 300 million people worldwide (1), with a mortality rate of up to 6%, usually [...]

Published
2022
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76. Neurophysiological correlate of incubation of craving in individuals with methamphetamine use disorder

Author

Zhao, Di, Zhang, Mingming, Tian, Weiwen, Cao, Xinyu, Yin, Lu, Liu, Yi, Xu, Tian-Le, Luo, Wenbo, and Yuan, Ti-Fei

Abstract

Previous studies both in laboratory animals and humans have reported that abstinence induces incubation of cue-induced drug craving for nicotine, alcohol, cocaine, and methamphetamine. However, current experimental procedures utilized to study incubation of methamphetamine craving do not incorporate the temporal dynamics of neuropsychological measures and electrophysiological activities associated with this incubation process. This study utilized the high-density electroencephalogram (EEG) signals as a rapid, inexpensive, and noninvasive measure of cue-induced craving potential. A total of 156 male individuals with methamphetamine use disorder (MUD) enrolled in this multisite, cross-sectional study. Structured clinical interview data, self-report questionnaires (cued craving, quality of sleep, impulsivity, anxiety, and depression) and resting-state, eye-closed 128 high-density channel EEG signals were collected at 5 abstinence duration time points (<1, 1–3, 3–6, 6–12, and 12–24 months) to track the neuropsychological and neurophysiological signatures. Cue-induced craving was higher after 1–3 months than after the other time points. This incubation effect was also observed for sleep quality but not for anxiety, depression, and impulsivity symptoms, along with exhibited decreased power spectrum for theta (5.5–8 Hz) and alpha (8–13 Hz), and increased in beta (16.5–26.5 Hz) frequency band. Source reconstructed resting-state EEG analysis showed increased synchronization of medial prefrontal cortex (MPFC) for the beta frequency band in 1–3 months abstinent MUD group, and associated with the incubation of craving. Remarkably, the robust incubation-related abnormalities may be driven by beta-band source space connectivity between MPFC and bilateral orbital gyrus (ORB). Our findings suggest the enhancement of beta activity in the incubation period most likely originates from a dysfunction involving frontal brain regions. This neurophysiological signature of incubation of craving can be used to identify individuals who might be most susceptible to relapse, providing a potential insight into future therapeutic interventions for MUD via neuromodulation of beta activity.

Published
2024
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77. Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex

Author

Cheng, Tong, Huang, Xiao-Dan, Hu, Xue-Fei, Wang, Si-Qi, Chen, Kai, Wei, Ji-An, Yan, Lan, So, Kwok-Fai, Yuan, Ti-Fei, and Zhang, Li

Abstract

Drug exposure impairs cortical plasticity and motor learning, which underlies the reduced behavioral flexibility in drug addiction. Physical exercise has been used to prevent relapse in drug rehabilitation program. However, the potential benefits and molecular mechanisms of physical exercise on drug-evoked motor-cortical dysfunctions are unknown. Here we report that 1-week treadmill training restores cocaine-induced synaptic deficits, in the form of improved in vivo spine formation, synaptic transmission, and spontaneous activities of cortical pyramidal neurons, as well as motor-learning ability. The synaptic and behavioral benefits relied on de novoprotein synthesis, which are directed by the activation of the mechanistic target of rapamycin (mTOR)-ribosomal protein S6 pathway. These findings establish synaptic functional restoration and mTOR signaling as the critical mechanism supporting physical exercise training in rehabilitating the addicted brain.

Published
2024
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78. Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance

Author

Niu, Lili, Guo, Yanchen, Lin, Zhengrong, Shi, Zhe, Bian, Tianyuan, Qi, Lin, Meng, Long, Grace, Anthony A., Zheng, Hairong, and Yuan, Ti-Fei

Abstract

Ultrasound stimulation is an emerging noninvasive option in treating neuropsychiatric disorders. The present study investigates the behavioral alterations resulting from ultrasound stimulation on the nucleus accumbens (NAc) in freely moving mice. Our results show that an acute ultrasound stimulation on the NAc, rather than the visual cortex or auditory cortex, led to a pronounced avoidance behavior, while repeated NAc ultrasound stimulation resulted in an obvious conditioned place aversion with changes in synaptic protein (GluA1/2 subunit) expression. Notably, NAc ultrasound stimulation suppressed the morphine-induced conditioned place preference. The results provide evidence that NAc ultrasound stimulation can be applied as a potential noninvasive therapeutic option in treating psychiatric disorders.

Published
2024
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85. Midbrain dopamine neurons arbiter OCD-like behavior

Author

Xue, Jinwen, primary, Qian, Dandan, additional, Zhang, Bingqian, additional, Yang, Jingxuan, additional, Li, Wei, additional, Bao, Yifei, additional, Qiu, Shi, additional, Fu, Yi, additional, Wang, Shaoli, additional, Yuan, Ti-Fei, additional, and Lu, Wei, additional

Published
2022
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93. Impaired social decision-making in males with methamphetamine use disorder.

Author

Li, Ming‐Hui, Zhang, Mingming, Yuan, Ti‐Fei, Rao, Li‐Lin, Li, Ming-Hui, Yuan, Ti-Fei, and Rao, Li-Lin

Subjects
METHAMPHETAMINE, INTERPERSONAL relations, RESEARCH funding
Abstract

Individuals with methamphetamine use disorder (MUD) commonly exhibit socially problematic behaviours. Investigating the prosocial decision-making of individuals with MUD could enable a better understanding of their impaired social functioning and help improve their social relationships. We conducted two studies to examine the performance of individuals with MUD and healthy controls on a modified dictator game. In Study 1, 55 male individuals with MUD and 34 healthy male participants made a series of choices between two pairs of monetary prizes for themselves and for others. In Study 2, 62 male individuals with MUD and 31 healthy male participants made the same choices as in Study 1 after a brief exposure to methamphetamine-related pictures. In both studies, we consistently found a context dependency of decreased prosociality in individuals with MUD. That is, individuals with MUD made fewer prosocial choices than healthy individuals in disadvantageous contexts (but not advantageous contexts). The results of the computational model suggested that the lower prosociality of individuals with MUD in disadvantageous contexts could be attributed to the lower weight placed on others' benefits. Moreover, when exposed to methamphetamine-related pictures, individuals with MUD showed less caution and slower encoding/motor speed than healthy individuals, and individuals with MUD with a longer history of methamphetamine use tended to respond less cautiously. Our findings provide evidence that in disadvantageous contexts, individuals with MUD show reduced prosociality and less consideration of others' benefits. Identifying the origin of the alterations in prosocial decision-making has implications for diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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100. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders

Author

Xiao, Xiao, Wang, Lu, Wang, Chuang, Yuan, Ti-Fei, Zhou, Dongsheng, Zheng, Fanfan, Li, Lingyi, Grigoroiu-Serbanescu, Maria, Ikeda, Masashi, Iwata, Nakao, Takahashi, Atsushi, Kamatani, Yoichiro, Kubo, Michiaki, Preisig, Martin, Kutalik, Zoltán, Castelao, Enrique, Pistis, Giorgio, Amin, Najaf, van Duijn, Cornelia M., Forstner, Andreas J., Strohmaier, Jana, Hecker, Julian, Schulze, Thomas G., Müller-Myhsok, Bertram, Reif, Andreas, Mitchell, Philip B., Martin, Nicholas G., Schofield, Peter R., Cichon, Sven, Nöthen, Markus M., Chang, Hong, Luo, Xiong-Jian, Fang, Yiru, Yao, Yong-Gang, Zhang, Chen, Rietschel, Marcella, Li, Ming, and Advanced Collaborative Study of Mood Disorder (COSMO) Team, MooDS Bipolar Consortium

Published
2017
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