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The reaction of 2‐alkynylanilines with phenyliodonium bis(trifluoroacetate) (PIFA) and diaryl ditellurides was found to conveniently afford the corresponding 3‐aryltelluroindoles via oxidative cyclization/tellurolation. A plausible mechanism involving the in situ formation of the reactive ArTeOCOCF3 from the reaction of PIFA and diaryl ditellurides, and the subsequent oxidative C−N/C−Te bond formations was postulated. [ABSTRACT FROM AUTHOR]

In this work, nano porous materials NiCuCoMn@TMOs were prepared by melt-spining and chemical delloying methods, and R-NiCuCoMn@TMOs were further prepared through heat treatment. The characterization of the material was analyzed by X-ray diffraction, scanning electron microscopy, and Xray photoelectron spectroscopy. The electrochemical performance testing of the electrodes was tested. As an anode material for lithium-ion batteries, R-NiCuCoMn@TMOs has a high capacity (394.9 mAh/g) at a current density of 0.1 A/g and exhibits an excellent capacity retention of 97.53% after 200 cycles. The material after heat treatment has the more abundant vacancies, lower charge transfer resistance (38 Ω) and better rate capability (with a specific capacity of 141.1 mAh/g at a current density of 2 A/g). Unique nano porous structure provides rich active site for reaction. The synergetic effect of multiple metal cations with different radius, valence states and reaction potentials makes R-NiCuCoMn@TMOs have a good volume tolerance to accommodate the volume change during the lithium-deintercalation process, and display a superior electrochemical performance. In addition, the raw material reserves of the electrode material are abundant, the price is low, and it is easy to realize mass production. This work provides a new idea for simple multielement transition metal oxide anode materials designing. [ABSTRACT FROM AUTHOR]

Background: This study aimed to investigate the predictive value of 18F‐FDG PET/CT for pathological response after neoadjuvant immunochemotherapy (NICT) in patients with esophageal squamous cell carcinoma (ESCC). Methods: The clinical data of 54 patients with ESCC who underwent two cycles of NICT followed by surgery were retrospectively analyzed. NICT consisted of PD‐1 blockade therapy combined with chemotherapy. 18F‐FDG PET/CT scans were performed before and after NICT. The pathological results after surgery were used to assess the degree of pathological response. The scan parameters of 18F‐FDG PET/CT and their changes before and after NICT were compared with the pathological response. Results: Among the 54 patients, 10 (18.5%) achieved complete pathological response (pCR) and 21 (38.9%) achieved major pathological response (MPR). The post‐NICT scan parameters and their changes were significantly associated with the pathological response. In addition, the values of the changes in the scanned parameters before and after treatment can further predict the pathological response of the patient. Conclusion: 18F‐FDG PET/CT is a useful tool to evaluate the efficacy of NICT and predict pathological response in patients with ESCC. The post‐NICT scan parameters and their changes can help identify patients who are likely to achieve pCR or MPR. [ABSTRACT FROM AUTHOR]

TiO2 materials are considered one of the promising candidates for lithium/sodium-ion batteries (L/SIBs) due to its excellent safety and abundant resources. However, the low ion diffusion coefficient becomes a bottleneck in restrict its development. In this work, three-dimensional (3D) porous hydrangea-shaped anatase TiO2 (ATO) was synthesized through the synergistic effect of de-alloying and SO42− induced chemical synthesis. During the chemical synthesis process, SO42− and TiO62− octahedra are bound by static electricity, as the spatial effect of SO42− can influence the octahedral arrangement in favor of precipitating anatase TiO2. In the SIBs, ATO as anode material provided an excellent capacity of 190 mAh g−1 after 100 cycles at a current density of 50 mA g−1. Electrochemical kinetic tests show that the pseudocapacitive behavior contributes to 86% of the capacity at a scan rate of 1 mV s−1, mainly due to the high specific surface area provided by its unique microstructure, and also shows excellent electrochemical performance in the LIBs tests. This study provides a novel strategy for the simple and large-scale production of TiO2 anode materials with high-performance L/SIBs. [ABSTRACT FROM AUTHOR]

Organic chlorine pesticides (OCPs) and antibiotics represent persistent organic pollutants and emerging pollutants, respectively. They can coexist in various environmental matrix, while their combined effects were seldom explored. Lindane was chosen to represent OCPs, and sulfamethoxazole (SMX) and tetracycline hydrochloride (TET) were chosen to represent antibiotics. The present study focused on the influences on tumor migration which is essential for both carcinogenesis and cancer treatment and aimed to explore the effects of the binary mixtures on the model organism Drosophila melanogaster. The individual effects showed that lindane significantly enhanced the tumor migration from the eye and brain of the larvae to the ventral nerve cord (VNC) in the concentration range of 40 -100 ng-g-1( P<0.05). SMX enhanced the tumor migration at the highest concentration of 400 ng-g-1, while TET increased the tumor migration from 600 to 1 000 ng-g-1 with a concentration-dependence. The binary mixtures were designed by direct equipartition method. The binary mixtures that contained lindane and SMX or TET significantly enhanced the tumor migration, with a dependence on the lindane-s concentrations. Compared with the predicted effects by independent action (IA) model, the binary mixtures showed synergistic toxicity interactions. Determination on the antioxidant responses showed that, lindane, SMX, TET and the binary mixtures commonly increased reactive oxygen species (ROS) while decreased glutathione (GSH). The effects of binary mixtures containing lindane and SMX on tumor migration were negatively correlated with their influences on catalase (CAT) activities, while such correlation was not observed in the effects of mixtures containing lindane and TET. Such difference was attributed to the different effects of SMX and TET on the antioxidants. Moreover, the effects of binary mixtures containing lindane and SMX, and those containing lindane and TET showed different hierarchical clustering positions. The effects of binary mixtures containing lindane and SMX on tumor migration were closely connected with both ROS and superoxide dismutase (SOD), while those of binary mixtures containing lindane and TET were closely connected with ROS. Such differences supported the attribution to the individual effects of SMX or TET on the antioxidants and also indicated that the antibiotic types can influence the toxicity mechanism of the binary mixtures. [ABSTRACT FROM AUTHOR]

Regarding the difficulties in the assessment of innovation and entrepreneurship teaching capability currently like biased qualitative assessment and less nonlinear quantitative assessment and insufficient assessment efficiency, an assessment model of innovation and entrepreneurship education targeted at local University students on the foundation of the Back Propagation (BP) neural network is designed. First, the contents of the questionnaire are carefully designed, on whose basis the assessment index system is built. Then, a BP neural network model is utilized for the purpose of comprehensively evaluating the collected data. Lastly, we carry out a demonstration study on innovation and entrepreneurship education, whose results reveal the students' professional knowledge and skills, participation in national competitions, and centralized entrepreneurship training camp play a key role and have a profound effect on innovation and entrepreneurship capability. The evaluation system is able to effectively assess the actual effects of innovation and entrepreneurship education, direct teachers' instructional activity, as well as motivate students to learn and practice. [ABSTRACT FROM AUTHOR]