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1,003 results on '"Yu, Jinhua"'

63. Uniting Ultrahigh Plasticity with Near‐Theoretical Strength in Submicron‐Scale Si via Surface Healing.

Author

Xu, Wei, Yu, Jinhua, Ding, Jun, Guo, Yunna, Deng, Lei, Zhang, Liqiang, Wan, Xiaoxuan, Zheng, Shaochuan, Wang, Yuecun, and Shan, Zhiwei

Abstract

As a typical hard but brittle material, Si tends to fracture abruptly at a stress well below its theoretical strength, even if the tested volume goes down to submicron scale, at which materials are usually nearly free of flaws or extended defects. Here, via the thermal–oxidation–mediated healing of the surface that is the preferred site for cracks or dislocations initiation, the premature fracture can be effectively inhibited and the over 50% homogeneous plastic strain with the near‐theoretical strength (twice the value of the unhealed counterpart) are united in submicron‐sized Si particles. In situ transmission electron microscope observations and atomistic simulations elucidate the confinement effect from the passivated and smoothened thermal oxide, which retards the dislocation nucleation and transforms the dominant deformation mechanism from partial dislocation to the more mobile full dislocation. This work demonstrates an effective and feasible surface engineering pathway to optimize the mechanical properties of Si at small scales. [ABSTRACT FROM AUTHOR]

Published
2024
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64. 3D Texture Feature Learning for Noninvasive Estimation of Gliomas Pathological Subtype

Author

Wu, Guoqing, Wang, Yuanyuan, Yu, Jinhua, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Crimi, Alessandro, editor, Bakas, Spyridon, editor, Kuijf, Hugo, editor, Keyvan, Farahani, editor, Reyes, Mauricio, editor, and van Walsum, Theo, editor

Published
2019
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81. Overall Survival Time Prediction for High Grade Gliomas Based on Sparse Representation Framework

Author

Wu, Guoqing, Wang, Yuanyuan, Yu, Jinhua, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Crimi, Alessandro, editor, Bakas, Spyridon, editor, Kuijf, Hugo, editor, Menze, Bjoern, editor, and Reyes, Mauricio, editor

Published
2018
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82. Brain Tumor Segmentation Using an Adversarial Network

Author

Li, Zeju, Wang, Yuanyuan, Yu, Jinhua, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Crimi, Alessandro, editor, Bakas, Spyridon, editor, Kuijf, Hugo, editor, Menze, Bjoern, editor, and Reyes, Mauricio, editor

Published
2018
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84. Halofantrine Hydrochloride Acts as an Antioxidant Ability Inhibitor That Enhances Oxidative Stress Damage to Candida albicans.

Author

Xiong, Juan, Wang, Li, Feng, Zhe, Hang, Sijin, Yu, Jinhua, Feng, Yanru, Lu, Hui, and Jiang, Yuanying

Subjects
CANDIDA albicans, OXIDATIVE stress, INVASIVE candidiasis, GREATER wax moth, REACTIVE oxygen species, PATHOGENIC fungi
Abstract

Candida albicans, a prominent opportunistic pathogenic fungus in the human population, possesses the capacity to induce life-threatening invasive candidiasis in individuals with compromised immune systems despite the existence of antifungal medications. When faced with macrophages or neutrophils, C. albicans demonstrates its capability to endure oxidative stress through the utilization of antioxidant enzymes. Therefore, the enhancement of oxidative stress in innate immune cells against C. albicans presents a promising therapeutic approach for the treatment of invasive candidiasis. In this study, we conducted a comprehensive analysis of a library of drugs approved by the Food and Drug Administration (FDA). We discovered that halofantrine hydrochloride (HAL) can augment the antifungal properties of oxidative damage agents (plumbagin, menadione, and H2O2) by suppressing the response of C. albicans to reactive oxygen species (ROS). Furthermore, our investigation revealed that the inhibitory mechanism of HAL on the oxidative response is dependent on Cap1. In addition, the antifungal activity of HAL has been observed in the Galleria mellonella infection model. These findings provide evidence that targeting the oxidative stress response of C. albicans and augmenting the fungicidal capacity of oxidative damage agents hold promise as effective antifungal strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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90. Reconstruction of Thin-Slice Medical Images Using Generative Adversarial Network

Author

Li, Zeju, Wang, Yuanyuan, Yu, Jinhua, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Wang, Qian, editor, Shi, Yinghuan, editor, Suk, Heung-Il, editor, and Suzuki, Kenji, editor

Published
2017
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