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55. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Author

Lin, Yingsong, Nakatochi, Masahiro, Hosono, Yasuyuki, Ito, Hidemi, Kamatani, Yoichiro, Inoko, Akihito, Sakamoto, Hiromi, Kinoshita, Fumie, Kobayashi, Yumiko, Ishii, Hiroshi, Ozaka, Masato, Sasaki, Takashi, Matsuyama, Masato, Sasahira, Naoki, Morimoto, Manabu, Kobayashi, Satoshi, Fukushima, Taito, Ueno, Makoto, Ohkawa, Shinichi, Egawa, Naoto, Kuruma, Sawako, Mori, Mitsuru, Nakao, Haruhisa, Adachi, Yasushi, Okuda, Masumi, Osaki, Takako, Kamiya, Shigeru, Wang, Chaochen, Hara, Kazuo, Shimizu, Yasuhiro, Miyamoto, Tatsuo, Hayashi, Yuko, Ebi, Hiromichi, Kohmoto, Tomohiro, Imoto, Issei, Kasugai, Yumiko, Murakami, Yoshinori, Akiyama, Masato, Ishigaki, Kazuyoshi, Matsuda, Koichi, Hirata, Makoto, Shimada, Kazuaki, Okusaka, Takuji, Kawaguchi, Takahisa, Takahashi, Meiko, Watanabe, Yoshiyuki, Kuriki, Kiyonori, Kadota, Aya, Okada, Rieko, Mikami, Haruo, Takezaki, Toshiro, Suzuki, Sadao, Yamaji, Taiki, Iwasaki, Motoki, Sawada, Norie, Goto, Atsushi, Kinoshita, Kengo, Fuse, Nobuo, Katsuoka, Fumiki, Shimizu, Atsushi, Nishizuka, Satoshi S., Tanno, Kozo, Suzuki, Ken, Okada, Yukinori, Horikoshi, Momoko, Yamauchi, Toshimasa, Kadowaki, Takashi, Yu, Herbert, Zhong, Jun, Amundadottir, Laufey T., Doki, Yuichiro, Ishii, Hideshi, Eguchi, Hidetoshi, Bogumil, David, Haiman, Christopher A., Le Marchand, Loic, Mori, Masaki, Risch, Harvey, Setiawan, Veronica W., Tsugane, Shoichiro, Wakai, Kenji, Yoshida, Teruhiko, Matsuda, Fumihiko, Kubo, Michiaki, Kikuchi, Shogo, and Matsuo, Keitaro

Published
2020
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56. Hula as a physical activity and social support intervention for sustained activity in female breast and gynecologic cancer survivors.

Author

Bantum, Erin O., Yamada, Paulette M., Makolo, TeMoana, Yu, Herbert, Pagano, Ian, Subia, Natalie, Walsh, Catherine, and Loo, Lenora W. M.

Subjects
PHYSICAL activity, GYNECOLOGIC cancer, SOCIAL support, CANCER survivors, BREAST cancer, LOW-calorie diet
Abstract

Background: Physical activity improves health and psychosocial functioning for people who have been diagnosed with cancer. Native Hawaiians face disparities for some cancers, including breast cancer. Delivering culturally grounded interventions has the potential to improve enjoyment and adherence to the intervention. We sought to test the adherence and impact of a 6 month randomized wait-list controlled trial of hula. Methods: In this randomized wait-list controlled design people who had been diagnosed with breast or gynecologic cancers were invited to participate with other cancer survivors in a group based setting. Participants were randomized to begin hula immediately or after six months. Attendance was collected and heart-rate measured three times per session. In addition, demographic data, self- report psychosocial data, and biological data (findings will be reported elsewhere) were collected at three time points: baseline, 6 months, and 12 months. The study included six months of hula, twice per week, 60 min each session. In addition, participants committed to practice 60 min per week at home. Results: Participants in the study (n = 42) attended, on average, 72% of the sessions. Significant increase in moderate physical activity (d = 0.50, p = 0.03) was observed in the intervention versus control group. For the measures of intra-individual changes pre-and post-intervention, an increase in total physical activity were seen in the intervention group (d = 0.69, p = 0.003), daily caloric intake decreased (d = -0.62, p = 0.007), and a reduction in waist circumference (d = -0.89, p = 0.0002) that was sustained six months after completion of the intervention. Psychosocially, cognitive functioning significantly declined from baseline to 12 months (d = -0.50, p = 0.03), with role functioning improving (d = 0.55, p = 0.02), social constraints increasing (d = 0.49, p = 0.03), and financial difficulties improving (d = -0.55, p = 0.02). Conclusion: Sustainable physical activity is crucial to improve both the survival and quality of life of cancer survivors. Culturally grounded interventions, such as hula have the potential to increase the maintenance of physical activity. In addition, they create a support group where the benefits of people who have all experienced cancer can gather and garner those benefits of social support, too. This study was registered as a clinical trial through the National Cancer Institute (NCT02351479). Clinical trial registration: Clinicaltrails.gov, NCT02351479. [ABSTRACT FROM AUTHOR]

Published
2023
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58. BPA, Parabens, and Phthalates in Relation to Endometrial Cancer Risk: A Case-Control Study Nested in the Multiethnic Cohort

Author

Sarink, Danja, Franke, Adrian A., White, Kami K., Wu, Anna H., Cheng, Iona, Quon, Brandon, Le Marchand, Loic, Wilkens, Lynne R., Yu, Herbert, and Merritt, Melissa A.

Subjects
Parabens -- Environmental aspects -- Health aspects, Endometrial cancer -- Risk factors, Phthalates -- Environmental aspects -- Health aspects, Bisphenol-A -- Environmental aspects -- Health aspects, Environmental issues, Health
Abstract

Introduction Bisphenol A (BPA), phthalates, parabens, and triclosan are endocrine disrupting chemicals (EDCs); that is, they are exogenous substances that alter functions of the endocrine system and may cause adverse [...]

Published
2021
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66. Supplementary Table 1. Risk of PTC associated with serum concentrations of TSH and thyroid hormones, stratified by gender and sample date. from Thyroid-Stimulating Hormone, Thyroid Hormones, and Risk of Papillary Thyroid Cancer: A Nested Case–Control Study

Author

Huang, Huang, primary, Rusiecki, Jennifer, primary, Zhao, Nan, primary, Chen, Yingtai, primary, Ma, Shuangge, primary, Yu, Herbert, primary, Ward, Mary H., primary, Udelsman, Robert, primary, and Zhang, Yawei, primary

Published
2023
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67. Supplementary table 8 from Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3

Author

Mocci, Evelina, primary, Kundu, Prosenjit, primary, Wheeler, William, primary, Arslan, Alan A., primary, Beane-Freeman, Laura E., primary, Bracci, Paige M., primary, Brennan, Paul, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Blackford, Amanda L., primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campa, Daniele, primary, Chanock, Stephen J., primary, Childs, Erica J., primary, Duell, Eric J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Goggins, Michael G., primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Hung, Rayjean J., primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Núria, primary, Milne, Roger L., primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Panico, Salvatore, primary, Peters, Ulrike, primary, Porta, Miquel, primary, Rabe, Kari G., primary, Riboli, Elio, primary, Rothman, Nathaniel, primary, Scelo, Ghislaine, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Stevens, Victoria L., primary, Strobel, Oliver, primary, Thompson, Ian M., primary, Tjonneland, Anne, primary, Trichopoulou, Antonia, primary, Van Den Eeden, Stephen K., primary, Wactawski-Wende, Jean, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Yuan, Fangcheng, primary, Zeleniuch-Jacquotte, Anne, primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Jacobs, Eric J., primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Kraft, Peter, primary, Chatterjee, Nilanjan, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
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69. Supplementary Figure 1 from Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer

Author

Long, Jirong, primary, Zheng, Wei, primary, Xiang, Yong-Bing, primary, Lose, Felicity, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Dubrowinskaja, Natalia, primary, Goodman, Marc T., primary, Salvesen, Helga B., primary, Fasching, Peter A., primary, Scott, Rodney J., primary, Delahanty, Ryan, primary, Zheng, Ying, primary, O'Mara, Tracy, primary, Healey, Catherine S., primary, Hodgson, Shirley, primary, Risch, Harvey, primary, Yang, Hannah P., primary, Amant, Frederic, primary, Turmanov, Nurzhan, primary, Schwake, Anita, primary, Lurie, Galina, primary, Trovik, Jone, primary, Beckmann, Matthias W., primary, Ashton, Katie, primary, Ji, Bu-Tian, primary, Bao, Ping-Ping, primary, Howarth, Kimberly, primary, Lu, Lingeng, primary, Lissowska, Jolanta, primary, Coenegrachts, Lieve, primary, Kaidarova, Dilyara, primary, Dürst, Matthias, primary, Thompson, Pamela J., primary, Krakstad, Camilla, primary, Ekici, Arif B., primary, Otton, Geoffrey, primary, Shi, Jiajun, primary, Zhang, Ben, primary, Gorman, Maggie, primary, Brinton, Louise, primary, Coosemans, An, primary, Matsuno, Rayna K., primary, Halle, Mari K., primary, Hein, Alexander, primary, Proietto, Anthony, primary, Cai, Hui, primary, Lu, Wei, primary, Dunning, Alison, primary, Easton, Douglas, primary, Gao, Yu-Tang, primary, Cai, Qiuyin, primary, Spurdle, Amanda B., primary, and Shu, Xiao-Ou, primary

Published
2023
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70. Supplementary Figure 2 from Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer

Author

Long, Jirong, primary, Zheng, Wei, primary, Xiang, Yong-Bing, primary, Lose, Felicity, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Dubrowinskaja, Natalia, primary, Goodman, Marc T., primary, Salvesen, Helga B., primary, Fasching, Peter A., primary, Scott, Rodney J., primary, Delahanty, Ryan, primary, Zheng, Ying, primary, O'Mara, Tracy, primary, Healey, Catherine S., primary, Hodgson, Shirley, primary, Risch, Harvey, primary, Yang, Hannah P., primary, Amant, Frederic, primary, Turmanov, Nurzhan, primary, Schwake, Anita, primary, Lurie, Galina, primary, Trovik, Jone, primary, Beckmann, Matthias W., primary, Ashton, Katie, primary, Ji, Bu-Tian, primary, Bao, Ping-Ping, primary, Howarth, Kimberly, primary, Lu, Lingeng, primary, Lissowska, Jolanta, primary, Coenegrachts, Lieve, primary, Kaidarova, Dilyara, primary, Dürst, Matthias, primary, Thompson, Pamela J., primary, Krakstad, Camilla, primary, Ekici, Arif B., primary, Otton, Geoffrey, primary, Shi, Jiajun, primary, Zhang, Ben, primary, Gorman, Maggie, primary, Brinton, Louise, primary, Coosemans, An, primary, Matsuno, Rayna K., primary, Halle, Mari K., primary, Hein, Alexander, primary, Proietto, Anthony, primary, Cai, Hui, primary, Lu, Wei, primary, Dunning, Alison, primary, Easton, Douglas, primary, Gao, Yu-Tang, primary, Cai, Qiuyin, primary, Spurdle, Amanda B., primary, and Shu, Xiao-Ou, primary

Published
2023
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72. Supplementary Tables from Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk

Author

Yuan, Fangcheng, primary, Hung, Rayjean J., primary, Walsh, Naomi, primary, Zhang, Han, primary, Platz, Elizabeth A., primary, Wheeler, William, primary, Song, Lei, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Rosendahl, Jonas, primary, Scelo, Ghislaine, primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Amiano, Pilar, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Brennan, Paul, primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campbell, Peter T., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Goggins, Michael G., primary, Hackert, Thilo, primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Katzke, Verena, primary, Kirsten, Holger, primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Nuria, primary, Milne, Roger L., primary, Murphy, Neil, primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Porta, Miquel, primary, Rabe, Kari G., primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Shi, Jianxin, primary, Duell, Eric J., primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Yu, Kai, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
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73. Data from A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53

Author

Mao, Chao, primary, Wang, Xiang, primary, Liu, Yating, primary, Wang, Min, primary, Yan, Bin, primary, Jiang, Yiqun, primary, Shi, Ying, primary, Shen, Yi, primary, Liu, Xiaoli, primary, Lai, Weiwei, primary, Yang, Rui, primary, Xiao, Desheng, primary, Cheng, Yan, primary, Liu, Shuang, primary, Zhou, Hu, primary, Cao, Ya, primary, Yu, Weishi, primary, Muegge, Kathrin, primary, Yu, Herbert, primary, and Tao, Yongguang, primary

Published
2023
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74. Data from Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3

Author

Mocci, Evelina, primary, Kundu, Prosenjit, primary, Wheeler, William, primary, Arslan, Alan A., primary, Beane-Freeman, Laura E., primary, Bracci, Paige M., primary, Brennan, Paul, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Blackford, Amanda L., primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campa, Daniele, primary, Chanock, Stephen J., primary, Childs, Erica J., primary, Duell, Eric J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Goggins, Michael G., primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Hung, Rayjean J., primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Núria, primary, Milne, Roger L., primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Panico, Salvatore, primary, Peters, Ulrike, primary, Porta, Miquel, primary, Rabe, Kari G., primary, Riboli, Elio, primary, Rothman, Nathaniel, primary, Scelo, Ghislaine, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Stevens, Victoria L., primary, Strobel, Oliver, primary, Thompson, Ian M., primary, Tjonneland, Anne, primary, Trichopoulou, Antonia, primary, Van Den Eeden, Stephen K., primary, Wactawski-Wende, Jean, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Yuan, Fangcheng, primary, Zeleniuch-Jacquotte, Anne, primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Jacobs, Eric J., primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Kraft, Peter, primary, Chatterjee, Nilanjan, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
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75. Correction: Clin Cancer Res 2008 14: 1065-1072 from Diagnostic Markers for Early Detection of Ovarian Cancer

Author

Visintin, Irene, primary, Feng, Ziding, primary, Longton, Gary, primary, Ward, David C., primary, Alvero, Ayesha B., primary, Lai, Yinglei, primary, Tenthorey, Jeannette, primary, Leiser, Aliza, primary, Flores-Saaib, Ruben, primary, Yu, Herbert, primary, Azori, Masoud, primary, Rutherford, Thomas, primary, Schwartz, Peter E., primary, and Mor, Gil, primary

Published
2023
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76. Data from Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk

Author

Yuan, Fangcheng, primary, Hung, Rayjean J., primary, Walsh, Naomi, primary, Zhang, Han, primary, Platz, Elizabeth A., primary, Wheeler, William, primary, Song, Lei, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Rosendahl, Jonas, primary, Scelo, Ghislaine, primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Amiano, Pilar, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Brennan, Paul, primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campbell, Peter T., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Goggins, Michael G., primary, Hackert, Thilo, primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Katzke, Verena, primary, Kirsten, Holger, primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Nuria, primary, Milne, Roger L., primary, Murphy, Neil, primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Porta, Miquel, primary, Rabe, Kari G., primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Shi, Jianxin, primary, Duell, Eric J., primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Yu, Kai, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
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77. Supplementary Data from Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3

Author

Mocci, Evelina, primary, Kundu, Prosenjit, primary, Wheeler, William, primary, Arslan, Alan A., primary, Beane-Freeman, Laura E., primary, Bracci, Paige M., primary, Brennan, Paul, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Blackford, Amanda L., primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campa, Daniele, primary, Chanock, Stephen J., primary, Childs, Erica J., primary, Duell, Eric J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Goggins, Michael G., primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Hung, Rayjean J., primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Núria, primary, Milne, Roger L., primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Panico, Salvatore, primary, Peters, Ulrike, primary, Porta, Miquel, primary, Rabe, Kari G., primary, Riboli, Elio, primary, Rothman, Nathaniel, primary, Scelo, Ghislaine, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Stevens, Victoria L., primary, Strobel, Oliver, primary, Thompson, Ian M., primary, Tjonneland, Anne, primary, Trichopoulou, Antonia, primary, Van Den Eeden, Stephen K., primary, Wactawski-Wende, Jean, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Yuan, Fangcheng, primary, Zeleniuch-Jacquotte, Anne, primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Jacobs, Eric J., primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Kraft, Peter, primary, Chatterjee, Nilanjan, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
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78. Supplementary Material and Methods; Supplementary Tables 1-6; and Supplementary Figure S1-15 from A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53

Author

Mao, Chao, primary, Wang, Xiang, primary, Liu, Yating, primary, Wang, Min, primary, Yan, Bin, primary, Jiang, Yiqun, primary, Shi, Ying, primary, Shen, Yi, primary, Liu, Xiaoli, primary, Lai, Weiwei, primary, Yang, Rui, primary, Xiao, Desheng, primary, Cheng, Yan, primary, Liu, Shuang, primary, Zhou, Hu, primary, Cao, Ya, primary, Yu, Weishi, primary, Muegge, Kathrin, primary, Yu, Herbert, primary, and Tao, Yongguang, primary

Published
2023
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79. Data from Polymorphisms in Inflammation Pathway Genes and Endometrial Cancer Risk

Author

Delahanty, Ryan J., primary, Xiang, Yong-Bing, primary, Spurdle, Amanda, primary, Beeghly-Fadiel, Alicia, primary, Long, Jirong, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Goodman, Marc T., primary, Zheng, Ying, primary, Salvesen, Helga B., primary, Bao, Ping-Ping, primary, Amant, Frederic, primary, Beckmann, Matthias W., primary, Coenegrachts, Lieve, primary, Coosemans, An, primary, Dubrowinskaja, Natalia, primary, Dunning, Alison, primary, Runnebaum, Ingo B., primary, Easton, Douglas, primary, Ekici, Arif B., primary, Fasching, Peter A., primary, Halle, Mari K., primary, Hein, Alexander, primary, Howarth, Kimberly, primary, Gorman, Maggie, primary, Kaydarova, Dylyara, primary, Krakstad, Camilla, primary, Lose, Felicity, primary, Lu, Lingeng, primary, Lurie, Galina, primary, O'Mara, Tracy, primary, Matsuno, Rayna K., primary, Pharoah, Paul, primary, Risch, Harvey, primary, Corssen, Madeleine, primary, Trovik, Jone, primary, Turmanov, Nurzhan, primary, Wen, Wanqing, primary, Lu, Wei, primary, Cai, Qiuyin, primary, Zheng, Wei, primary, and Shu, Xiao-Ou, primary

Published
2023
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81. Supplementary Tables 1 - 2 from Polymorphisms in Inflammation Pathway Genes and Endometrial Cancer Risk

Author

Delahanty, Ryan J., primary, Xiang, Yong-Bing, primary, Spurdle, Amanda, primary, Beeghly-Fadiel, Alicia, primary, Long, Jirong, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Goodman, Marc T., primary, Zheng, Ying, primary, Salvesen, Helga B., primary, Bao, Ping-Ping, primary, Amant, Frederic, primary, Beckmann, Matthias W., primary, Coenegrachts, Lieve, primary, Coosemans, An, primary, Dubrowinskaja, Natalia, primary, Dunning, Alison, primary, Runnebaum, Ingo B., primary, Easton, Douglas, primary, Ekici, Arif B., primary, Fasching, Peter A., primary, Halle, Mari K., primary, Hein, Alexander, primary, Howarth, Kimberly, primary, Gorman, Maggie, primary, Kaydarova, Dylyara, primary, Krakstad, Camilla, primary, Lose, Felicity, primary, Lu, Lingeng, primary, Lurie, Galina, primary, O'Mara, Tracy, primary, Matsuno, Rayna K., primary, Pharoah, Paul, primary, Risch, Harvey, primary, Corssen, Madeleine, primary, Trovik, Jone, primary, Turmanov, Nurzhan, primary, Wen, Wanqing, primary, Lu, Wei, primary, Cai, Qiuyin, primary, Zheng, Wei, primary, and Shu, Xiao-Ou, primary

Published
2023
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82. Supplementary Tables 1 - 4 from Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer

Author

Long, Jirong, primary, Zheng, Wei, primary, Xiang, Yong-Bing, primary, Lose, Felicity, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Dubrowinskaja, Natalia, primary, Goodman, Marc T., primary, Salvesen, Helga B., primary, Fasching, Peter A., primary, Scott, Rodney J., primary, Delahanty, Ryan, primary, Zheng, Ying, primary, O'Mara, Tracy, primary, Healey, Catherine S., primary, Hodgson, Shirley, primary, Risch, Harvey, primary, Yang, Hannah P., primary, Amant, Frederic, primary, Turmanov, Nurzhan, primary, Schwake, Anita, primary, Lurie, Galina, primary, Trovik, Jone, primary, Beckmann, Matthias W., primary, Ashton, Katie, primary, Ji, Bu-Tian, primary, Bao, Ping-Ping, primary, Howarth, Kimberly, primary, Lu, Lingeng, primary, Lissowska, Jolanta, primary, Coenegrachts, Lieve, primary, Kaidarova, Dilyara, primary, Dürst, Matthias, primary, Thompson, Pamela J., primary, Krakstad, Camilla, primary, Ekici, Arif B., primary, Otton, Geoffrey, primary, Shi, Jiajun, primary, Zhang, Ben, primary, Gorman, Maggie, primary, Brinton, Louise, primary, Coosemans, An, primary, Matsuno, Rayna K., primary, Halle, Mari K., primary, Hein, Alexander, primary, Proietto, Anthony, primary, Cai, Hui, primary, Lu, Wei, primary, Dunning, Alison, primary, Easton, Douglas, primary, Gao, Yu-Tang, primary, Cai, Qiuyin, primary, Spurdle, Amanda B., primary, and Shu, Xiao-Ou, primary

Published
2023
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83. {Supplementary Data} from Diagnostic Markers for Early Detection of Ovarian Cancer

Author

Visintin, Irene, primary, Feng, Ziding, primary, Longton, Gary, primary, Ward, David C., primary, Alvero, Ayesha B., primary, Lai, Yinglei, primary, Tenthorey, Jeannette, primary, Leiser, Aliza, primary, Flores-Saaib, Ruben, primary, Yu, Herbert, primary, Azori, Masoud, primary, Rutherford, Thomas, primary, Schwartz, Peter E., primary, and Mor, Gil, primary

Published
2023
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84. Supplementary Figure 1 from Polymorphisms in Inflammation Pathway Genes and Endometrial Cancer Risk

Author

Delahanty, Ryan J., primary, Xiang, Yong-Bing, primary, Spurdle, Amanda, primary, Beeghly-Fadiel, Alicia, primary, Long, Jirong, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Goodman, Marc T., primary, Zheng, Ying, primary, Salvesen, Helga B., primary, Bao, Ping-Ping, primary, Amant, Frederic, primary, Beckmann, Matthias W., primary, Coenegrachts, Lieve, primary, Coosemans, An, primary, Dubrowinskaja, Natalia, primary, Dunning, Alison, primary, Runnebaum, Ingo B., primary, Easton, Douglas, primary, Ekici, Arif B., primary, Fasching, Peter A., primary, Halle, Mari K., primary, Hein, Alexander, primary, Howarth, Kimberly, primary, Gorman, Maggie, primary, Kaydarova, Dylyara, primary, Krakstad, Camilla, primary, Lose, Felicity, primary, Lu, Lingeng, primary, Lurie, Galina, primary, O'Mara, Tracy, primary, Matsuno, Rayna K., primary, Pharoah, Paul, primary, Risch, Harvey, primary, Corssen, Madeleine, primary, Trovik, Jone, primary, Turmanov, Nurzhan, primary, Wen, Wanqing, primary, Lu, Wei, primary, Cai, Qiuyin, primary, Zheng, Wei, primary, and Shu, Xiao-Ou, primary

Published
2023
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85. Supplementary Figure Legend from Polymorphisms in Inflammation Pathway Genes and Endometrial Cancer Risk

Author

Delahanty, Ryan J., primary, Xiang, Yong-Bing, primary, Spurdle, Amanda, primary, Beeghly-Fadiel, Alicia, primary, Long, Jirong, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Goodman, Marc T., primary, Zheng, Ying, primary, Salvesen, Helga B., primary, Bao, Ping-Ping, primary, Amant, Frederic, primary, Beckmann, Matthias W., primary, Coenegrachts, Lieve, primary, Coosemans, An, primary, Dubrowinskaja, Natalia, primary, Dunning, Alison, primary, Runnebaum, Ingo B., primary, Easton, Douglas, primary, Ekici, Arif B., primary, Fasching, Peter A., primary, Halle, Mari K., primary, Hein, Alexander, primary, Howarth, Kimberly, primary, Gorman, Maggie, primary, Kaydarova, Dylyara, primary, Krakstad, Camilla, primary, Lose, Felicity, primary, Lu, Lingeng, primary, Lurie, Galina, primary, O'Mara, Tracy, primary, Matsuno, Rayna K., primary, Pharoah, Paul, primary, Risch, Harvey, primary, Corssen, Madeleine, primary, Trovik, Jone, primary, Turmanov, Nurzhan, primary, Wen, Wanqing, primary, Lu, Wei, primary, Cai, Qiuyin, primary, Zheng, Wei, primary, and Shu, Xiao-Ou, primary

Published
2023
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86. Supplementary Methods from Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer

Author

Long, Jirong, primary, Zheng, Wei, primary, Xiang, Yong-Bing, primary, Lose, Felicity, primary, Thompson, Deborah, primary, Tomlinson, Ian, primary, Yu, Herbert, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Dörk, Thilo, primary, Dubrowinskaja, Natalia, primary, Goodman, Marc T., primary, Salvesen, Helga B., primary, Fasching, Peter A., primary, Scott, Rodney J., primary, Delahanty, Ryan, primary, Zheng, Ying, primary, O'Mara, Tracy, primary, Healey, Catherine S., primary, Hodgson, Shirley, primary, Risch, Harvey, primary, Yang, Hannah P., primary, Amant, Frederic, primary, Turmanov, Nurzhan, primary, Schwake, Anita, primary, Lurie, Galina, primary, Trovik, Jone, primary, Beckmann, Matthias W., primary, Ashton, Katie, primary, Ji, Bu-Tian, primary, Bao, Ping-Ping, primary, Howarth, Kimberly, primary, Lu, Lingeng, primary, Lissowska, Jolanta, primary, Coenegrachts, Lieve, primary, Kaidarova, Dilyara, primary, Dürst, Matthias, primary, Thompson, Pamela J., primary, Krakstad, Camilla, primary, Ekici, Arif B., primary, Otton, Geoffrey, primary, Shi, Jiajun, primary, Zhang, Ben, primary, Gorman, Maggie, primary, Brinton, Louise, primary, Coosemans, An, primary, Matsuno, Rayna K., primary, Halle, Mari K., primary, Hein, Alexander, primary, Proietto, Anthony, primary, Cai, Hui, primary, Lu, Wei, primary, Dunning, Alison, primary, Easton, Douglas, primary, Gao, Yu-Tang, primary, Cai, Qiuyin, primary, Spurdle, Amanda B., primary, and Shu, Xiao-Ou, primary

Published
2023
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89. supplemental materials and methods from Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone–Related Protein

Author

Kim, Wonnam, primary, Takyar, Farzin M., primary, Swan, Karena, primary, Jeong, Jaekwang, primary, VanHouten, Joshua, primary, Sullivan, Catherine, primary, Dann, Pamela, primary, Yu, Herbert, primary, Fiaschi-Taesch, Nathalie, primary, Chang, Wenhan, primary, and Wysolmerski, John, primary

Published
2023
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91. Data from A KRAS-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk

Author

Ratner, Elena, primary, Lu, Lingeng, primary, Boeke, Marta, primary, Barnett, Rachel, primary, Nallur, Sunitha, primary, Chin, Lena J., primary, Pelletier, Cory, primary, Blitzblau, Rachel, primary, Tassi, Renata, primary, Paranjape, Trupti, primary, Hui, Pei, primary, Godwin, Andrew K., primary, Yu, Herbert, primary, Risch, Harvey, primary, Rutherford, Thomas, primary, Schwartz, Peter, primary, Santin, Alessandro, primary, Matloff, Ellen, primary, Zelterman, Daniel, primary, Slack, Frank J., primary, and Weidhaas, Joanne B., primary

Published
2023
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92. Supplementary Table 1 from A KRAS-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk

Author

Ratner, Elena, primary, Lu, Lingeng, primary, Boeke, Marta, primary, Barnett, Rachel, primary, Nallur, Sunitha, primary, Chin, Lena J., primary, Pelletier, Cory, primary, Blitzblau, Rachel, primary, Tassi, Renata, primary, Paranjape, Trupti, primary, Hui, Pei, primary, Godwin, Andrew K., primary, Yu, Herbert, primary, Risch, Harvey, primary, Rutherford, Thomas, primary, Schwartz, Peter, primary, Santin, Alessandro, primary, Matloff, Ellen, primary, Zelterman, Daniel, primary, Slack, Frank J., primary, and Weidhaas, Joanne B., primary

Published
2023
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93. Supplementary Figure 1 from A KRAS-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk

Author

Ratner, Elena, primary, Lu, Lingeng, primary, Boeke, Marta, primary, Barnett, Rachel, primary, Nallur, Sunitha, primary, Chin, Lena J., primary, Pelletier, Cory, primary, Blitzblau, Rachel, primary, Tassi, Renata, primary, Paranjape, Trupti, primary, Hui, Pei, primary, Godwin, Andrew K., primary, Yu, Herbert, primary, Risch, Harvey, primary, Rutherford, Thomas, primary, Schwartz, Peter, primary, Santin, Alessandro, primary, Matloff, Ellen, primary, Zelterman, Daniel, primary, Slack, Frank J., primary, and Weidhaas, Joanne B., primary

Published
2023
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95. Supplementary Table 2 from A KRAS-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk

Author

Ratner, Elena, primary, Lu, Lingeng, primary, Boeke, Marta, primary, Barnett, Rachel, primary, Nallur, Sunitha, primary, Chin, Lena J., primary, Pelletier, Cory, primary, Blitzblau, Rachel, primary, Tassi, Renata, primary, Paranjape, Trupti, primary, Hui, Pei, primary, Godwin, Andrew K., primary, Yu, Herbert, primary, Risch, Harvey, primary, Rutherford, Thomas, primary, Schwartz, Peter, primary, Santin, Alessandro, primary, Matloff, Ellen, primary, Zelterman, Daniel, primary, Slack, Frank J., primary, and Weidhaas, Joanne B., primary

Published
2023
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96. Supplementary Figure 2 from A KRAS-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk

Author

Ratner, Elena, primary, Lu, Lingeng, primary, Boeke, Marta, primary, Barnett, Rachel, primary, Nallur, Sunitha, primary, Chin, Lena J., primary, Pelletier, Cory, primary, Blitzblau, Rachel, primary, Tassi, Renata, primary, Paranjape, Trupti, primary, Hui, Pei, primary, Godwin, Andrew K., primary, Yu, Herbert, primary, Risch, Harvey, primary, Rutherford, Thomas, primary, Schwartz, Peter, primary, Santin, Alessandro, primary, Matloff, Ellen, primary, Zelterman, Daniel, primary, Slack, Frank J., primary, and Weidhaas, Joanne B., primary

Published
2023
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97. supplemental figure legends from Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone–Related Protein

Author

Kim, Wonnam, primary, Takyar, Farzin M., primary, Swan, Karena, primary, Jeong, Jaekwang, primary, VanHouten, Joshua, primary, Sullivan, Catherine, primary, Dann, Pamela, primary, Yu, Herbert, primary, Fiaschi-Taesch, Nathalie, primary, Chang, Wenhan, primary, and Wysolmerski, John, primary

Published
2023
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98. Association of SNPs in the PAI1 Gene with Disease Recurrence and Clinical Outcome in Bladder Cancer

Author

Murakami, Kaoru, primary, Furuya, Hideki, additional, Hokutan, Kanani, additional, Goodison, Steve, additional, Pagano, Ian, additional, Chen, Runpu, additional, Shen, Cheng-Huang, additional, Chan, Michael W. Y., additional, Ng, Chi Fai, additional, Kobayashi, Takashi, additional, Ogawa, Osamu, additional, Miyake, Makito, additional, Thornquist, Mark, additional, Shimizu, Yoshiko, additional, Hayashi, Kazukuni, additional, Wang, Zhangwei, additional, Yu, Herbert, additional, and Rosser, Charles J., additional

Published
2023
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99. Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium : An individual-participant meta-analysis

Author

Brasky, Theodore M., Hade, Erinn M., Cohn, David E., Newton, Alison M., Petruzella, Stacey, O'Connell, Kelli, Bertrand, Kimberly A., Cook, Linda S., De Vivo, Immaculata, Du, Mengmeng, Freudenheim, Jo L., Friedenreich, Christine M., Goodman, Marc T., Gorzelitz, Jessica, Ibiebele, Torukiri I., Krogh, Vittorio, Liao, Linda M., Lipworth, Loren, Lu, Lingeng, McCann, Susan, O'Mara, Tracy A., Palmer, Julie R., Ponte, Jeanette, Prizment, Anna, Risch, Harvey, Sandin, Sven, Schouten, Leo J., Setiawan, Veronica Wendy, Shu, Xiao-ou, Trabert, Britton, Brandt, Piet A. van den, Webb, Penelope M., Wentzensen, Nicolas, Wilkens, Lynne R., Wolk, Alicja, Yu, Herbert, Neuhouser, Marian L., Brasky, Theodore M., Hade, Erinn M., Cohn, David E., Newton, Alison M., Petruzella, Stacey, O'Connell, Kelli, Bertrand, Kimberly A., Cook, Linda S., De Vivo, Immaculata, Du, Mengmeng, Freudenheim, Jo L., Friedenreich, Christine M., Goodman, Marc T., Gorzelitz, Jessica, Ibiebele, Torukiri I., Krogh, Vittorio, Liao, Linda M., Lipworth, Loren, Lu, Lingeng, McCann, Susan, O'Mara, Tracy A., Palmer, Julie R., Ponte, Jeanette, Prizment, Anna, Risch, Harvey, Sandin, Sven, Schouten, Leo J., Setiawan, Veronica Wendy, Shu, Xiao-ou, Trabert, Britton, Brandt, Piet A. van den, Webb, Penelope M., Wentzensen, Nicolas, Wilkens, Lynne R., Wolk, Alicja, Yu, Herbert, and Neuhouser, Marian L.

Abstract

Background. Limited data from prospective studies suggest that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA), which hold anti-inflammatory properties, may reduce endometrial can-cer risk; particularly among certain subgroups characterized by body mass and tumor pathology. Materials and methods. Data from 12 prospective cohort studies participating in the Epidemiology of Endome-trial Cancer Consortium were harmonized as nested case-control studies, including 7268 endometrial cancer cases and 26,133 controls. Habitual diet was assessed by food frequency questionnaire, from which fatty acid in-takes were estimated. Two-stage individual-participant data mixed effects meta-analysis estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) through logistic regression for associations between study -specific energy-adjusted quartiles of LCn3PUFA and endometrial cancer risk. Results. Women with the highest versus lowest estimated dietary intakes of docosahexaenoic acid, the most abundant LCn3PUFA in diet, had a 9% increased endometrial cancer risk (Quartile 4 vs. Quartile 1: OR 1.09, 95% CI: 1.01-1.19; P trend = 0.04). Similar elevated risks were observed for the summary measure of total LCn3PUFA (OR 1.07, 95% CI: 0.99-1.16; P trend = 0.06). Stratified by body mass index, higher intakes of LCn3PUFA were as-sociated with 12-19% increased endometrial cancer risk among overweight/obese women and no increased risk among normal-weight women. Higher associations appeared restricted to White women. The results did not dif-fer by cancer grade. Conclusion. Higher dietary intakes of LCn3PUFA are unlikely to reduce endometrial cancer incidence; rather, they may be associated with small to moderate increases in risk in some subgroups of women, particularly over-weight/obese women.(c) 2022 Elsevier Inc. All rights reserved.

Published
2023
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100. Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., Veliginti, Swathi, Brouwers, Martijn C G J, Ren, Zhewen, Zheng, Wei, Setiawan, Veronica W., Wilkens, Lynne R., Shu, Xiao-Ou, Arslan, Alan A., Beane Freeman, Laura E., Bracci, Paige M., Canzian, Federico, Du, Mengmeng, Gallinger, Steven J., Giles, Graham G., Goodman, Phyllis J., Haiman, Christopher A., Kogevinas, Manolis, Kooperberg, Charles, LeMarchand, Loic, Neale, Rachel E., Visvanathan, Kala, White, Emily, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Berndt, Sonja I., Brais, Lauren K., Brennan, Paul, Buring, Julie E., Rabe, Kari G., Bamlet, William R., Chanock, Stephen J., Fuchs, Charles S., Gaziano, J Michael, Giovannucci, Edward L., Hackert, Thilo, Hassan, Manal M., Katzke, Verena, Kurtz, Robert C., Lee, I-Min, Malats, Núria, Murphy, Neil, Oberg, Ann L., Orlow, Irene, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Sesso, Howard D., Silverman, Debra T., Thompson, Ian M., Wactawski-Wende, Jean, Wang, Xiaoliang, Wentzensen, Nicolas, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Yu, Kai, Wolpin, Brian M., Duell, Eric J., Li, Donghui, Hung, Rayjean J., Perdomo, Sandra, McCullough, Marjorie L., Freedman, Neal D., Patel, Alpa V., Peters, Ulrike, Riboli, Elio, Sund, Malin, Tjønneland, Anne, Zhong, Jun, Van Den Eeden, Stephen K., Kraft, Peter, Risch, Harvey A., Amundadottir, Laufey T., Klein, Alison P., Stolzenberg-Solomon, Rachael Z., Antwi, Samuel O., King, Sontoria D., Veliginti, Swathi, Brouwers, Martijn C G J, Ren, Zhewen, Zheng, Wei, Setiawan, Veronica W., Wilkens, Lynne R., Shu, Xiao-Ou, Arslan, Alan A., Beane Freeman, Laura E., Bracci, Paige M., Canzian, Federico, Du, Mengmeng, Gallinger, Steven J., Giles, Graham G., Goodman, Phyllis J., Haiman, Christopher A., Kogevinas, Manolis, Kooperberg, Charles, LeMarchand, Loic, Neale, Rachel E., Visvanathan, Kala, White, Emily, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Berndt, Sonja I., Brais, Lauren K., Brennan, Paul, Buring, Julie E., Rabe, Kari G., Bamlet, William R., Chanock, Stephen J., Fuchs, Charles S., Gaziano, J Michael, Giovannucci, Edward L., Hackert, Thilo, Hassan, Manal M., Katzke, Verena, Kurtz, Robert C., Lee, I-Min, Malats, Núria, Murphy, Neil, Oberg, Ann L., Orlow, Irene, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Sesso, Howard D., Silverman, Debra T., Thompson, Ian M., Wactawski-Wende, Jean, Wang, Xiaoliang, Wentzensen, Nicolas, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Yu, Kai, Wolpin, Brian M., Duell, Eric J., Li, Donghui, Hung, Rayjean J., Perdomo, Sandra, McCullough, Marjorie L., Freedman, Neal D., Patel, Alpa V., Peters, Ulrike, Riboli, Elio, Sund, Malin, Tjønneland, Anne, Zhong, Jun, Van Den Eeden, Stephen K., Kraft, Peter, Risch, Harvey A., Amundadottir, Laufey T., Klein, Alison P., Stolzenberg-Solomon, Rachael Z., and Antwi, Samuel O.

Abstract

BACKGROUND: There are conflicting data on whether nonalcoholic fatty liver disease (NAFLD) is associated with susceptibility to pancreatic cancer. Using Mendelian randomization (MR), we investigated the relationship between genetic predisposition to NAFLD and risk for pancreatic cancer. METHODS: Data from genome-wide association studies (GWAS) within the Pancreatic Cancer Cohort Consortium (PanScan; cases n = 5,090, controls n = 8,733) and the Pancreatic Cancer Case Control Consortium (PanC4; cases n = 4,163, controls n = 3,792) were analyzed. We used data on 68 genetic variants with four different MR methods [inverse variance weighting (IVW), MR-Egger, simple median, and penalized weighted median] separately to predict genetic heritability of NAFLD. We then assessed the relationship between each of the four MR methods and pancreatic cancer risk, using logistic regression to calculate ORs and 95% confidence intervals (CI), adjusting for PC risk factors, including obesity and diabetes. RESULTS: No association was found between genetically predicted NAFLD and pancreatic cancer risk in the PanScan or PanC4 samples [e.g., PanScan, IVW OR, 1.04; 95% confidence interval (CI), 0.88-1.22; MR-Egger OR, 0.89; 95% CI, 0.65-1.21; PanC4, IVW OR, 1.07; 95% CI, 0.90-1.27; MR-Egger OR, 0.93; 95% CI, 0.67-1.28]. None of the four MR methods indicated an association between genetically predicted NAFLD and pancreatic cancer risk in either sample. CONCLUSIONS: Genetic predisposition to NAFLD is not associated with pancreatic cancer risk. IMPACT: Given the close relationship between NAFLD and metabolic conditions, it is plausible that any association between NAFLD and pancreatic cancer might reflect host metabolic perturbations (e.g., obesity, diabetes, or metabolic syndrome) and does not necessarily reflect a causal relationship between NAFLD and pancreatic cancer.

Published
2023
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