Search

Your search keyword '"Young, W L"' showing total 392 results
Start Over Author "Young, W L"
392 results on '"Young, W L"'

94. Effect of intracarotid papaverine on human cerebral blood flow and vascular resistance during acute hemispheric arterial hypotension.

Author

Joshi, Shailendra, Hashimoto, Tomoki, Ostapkovich, Noeleen, Pile-Spellman, John, Duong, D. Hoang, Hacien-Bey, Lofti, Marshall, Randolph S., James, David J., Young, William L., Joshi, S, Hashimoto, T, Ostapkovich, N, Pile-Spellman, J, Duong, D H, Hacein-Bey, L, Hacien-Bey, L, Marshall, R S, James, D J, and Young, W L

Published
2001
Full Text
View/download PDF

97. The 4G/4G Genotype of the PAI‐1 (Serpine‐1)4G/5G Polymorphism Is Associated With Decreased Lung Allograft Utilization

Author

Sapru, A., Zaroff, J. G., Pawlikowska, L., Liu, K. D., Khush, K. K., Baxter‐Lowe, L. A., Hayden, V., Menza, R. L., Convery, M., Lo, V., Poon, A., Kim, H., Young, W. L., Kukreja, J., and Matthay, M. A.

Abstract

Widespread thrombi are found among donor lungs rejected for transplantation. The 4G/5G polymorphism in the plasminogen activator inhibitor (PAI‐1) gene impacts transcription and the 4G allele is associated with increased PAI‐1 levels. We hypothesized that the 4G/4G genotype would be associated with decreased lung graft utilization, potentially because of worse oxygenation in the donor. We genotyped donors managed by the California Transplant Donor Network from 2001 to 2008 for the 4G/5G polymorphism in the PAI‐1 gene. Non‐Hispanic donors from 2001 to 2005 defined the discovery cohort (n = 519), whereas donors from 2006 to 2008 defined the validation cohort (n = 369). We found, that the odds of successful lung utilization among Non‐Hispanic white donors were lower among donors with the 4G/4G genotype compared to those without this genotype in both the discovery (OR = 0.55, 95% CI = 0.3–0.9, p = 0.02) and validation (OR = 0.5, 95% CI = 0.3–0.9, p = 0.03) cohorts. This relationship was independent of age, gender, cause of death, drug use and history of smoking. Donors with the 4G/4G genotype also had a lower PaO2/FiO2 ratio (p = 0.03) and fewer donors with the 4G/4G genotype achieved the threshold PaO2/FiO2 ratio ≥ 300 (p = 0.05). These findings suggest a role for impaired fibrinolysis resulting in worse gas exchange and decreased donor utilization.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results