372 results on '"Yoshiro Matsui"'
Search Results
52. Noninvasive management for iatrogenic splenic injury caused by chest tube insertion: a case report
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Tatsunosuke Ichimura, Kichizo Kaga, Yoshiro Matsui, Ryunosuke Hase, Kazuto Ohtaka, Ryohei Chiba, Mamoru Miyasaka, Yasuhito Shoji, Shoki Sato, and Naoto Senmaru
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Chest tube insertion ,General Medicine ,Case Reports ,030204 cardiovascular system & hematology ,Surgery ,Chest tube ,03 medical and health sciences ,noninvasive management ,0302 clinical medicine ,chest tube ,030220 oncology & carcinogenesis ,Case report ,medicine ,Tube (fluid conveyance) ,iatrogenic splenic injury ,Adverse effect ,business - Abstract
Key Clinical Message Splenic injury is one of the most critical complications of chest tube insertion and often requires invasive emergency management. However, noninvasive management such as delayed removal of the malpositioned tube may be considered for a stable patient without severe adverse event.
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- 2016
53. Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients
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Tatsuya Kato, Priya Patel, Kichizo Kaga, Hideki Ujiie, Takahiro Nakajima, Yoshiro Matsui, Kazuhiro Yasufuku, Mitsuhito Kaji, Masaaki Sato, Kentaro Hirohashi, Hironobu Wada, Hsin-pei Hu, Ming-Sound Tsao, and Daiyoon Lee
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Adult ,Male ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,Cancer Research ,Small interfering RNA ,Pathology ,medicine.medical_specialty ,Lung Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,Cell Line, Tumor ,medicine ,Humans ,Lung cancer ,Aged ,Aged, 80 and over ,Lung ,Tissue microarray ,business.industry ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Up-Regulation ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Cancer cell ,Cancer research ,Immunohistochemistry ,Adenocarcinoma ,Female ,business ,Microtubule-Associated Proteins - Abstract
Objective High-level expression of kinesin family member 23 (KIF23), a member of microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division, has been observed in a variety of human malignancies. The aims of the present study were to observe the expression of KIF23 in lung cancer, examine the role of KIF23 in lung cancer cell growth and/or survival by small interfering RNA experiments, and explore its clinicopathologic significance and evaluate KIF23 expression as a prognostic marker. Materials and methods Quantitative reverse transcription-polymerase chain reaction analysis was performed to detect the expression of KIF23 mRNA using metastatic lymph nodes from patients with advanced lung cancer obtained by endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA) and primary lung tumors through surgical sample. The role of KIF23 in cancer cell growth was examined by small interfering RNA experiments. A total of 339 lung cancers were analyzed immunohistochemically on tissue microarrays to examine the expression of KIF23 protein and its clinicopathologic significance. Results KIF23 transcript was found to be overexpressed in the great majority of metastatic lymph nodes from advanced lung cancers and primary lung tumors. Inhibiting KIF23 expression effectively suppressed lung cancer cell growth. High-level KIF23 expression was observed in 67.8% of the 339 cases. Lung adenocarcinoma patients with tumors displaying a high-level of KIF23 expression was also identified as an independent prognostic factor by multivariate analysis ( P =0.0064). Conclusion KIF23 not only provides additional prognostic information for surgical treatment of lung cancer, but may also be a novel therapeutic target for these patients.
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- 2016
54. The impact of preoperative identification of the Adamkiewicz artery on descending and thoracoabdominal aortic repair
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Yutaka Okita, Hiroshi Tanaka, Taijiro Sueda, Kenji Minatoya, Takahiro Katsumata, Shigeyuki Aomi, Yukio Kuniyoshi, Tetsuya Higami, Yoshiki Sawa, Hitoshi Okabayashi, Hidetoshi Akashi, Yoshikatsu Saiki, Hitoshi Ogino, Norihiko Shiiya, and Yoshiro Matsui
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Male ,030204 cardiovascular system & hematology ,Magnetic resonance angiography ,0302 clinical medicine ,Japan ,Risk Factors ,Odds Ratio ,Hospital Mortality ,Registries ,Spinal cord injury ,Computed tomography angiography ,Aged, 80 and over ,medicine.diagnostic_test ,Incidence ,Middle Aged ,Treatment Outcome ,Spinal Cord ,Elective Surgical Procedures ,Anesthesia ,Predictive value of tests ,Female ,Anatomic Landmarks ,Cardiology and Cardiovascular Medicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Aortography ,Preoperative care ,Blood Vessel Prosthesis Implantation ,03 medical and health sciences ,Predictive Value of Tests ,medicine.artery ,Preoperative Care ,medicine ,Humans ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aortic Segment ,Aorta ,Aortic Aneurysm, Thoracic ,Spinal Cord Ischemia ,business.industry ,medicine.disease ,Surgery ,030228 respiratory system ,Multivariate Analysis ,Emergencies ,Tomography, X-Ray Computed ,business ,Magnetic Resonance Angiography - Abstract
Objective To investigate the impact of preoperative identification of the Adamkiewicz artery (AKA) on prevention of spinal cord injury (SCI) through the multicenter Japanese Study of Spinal Cord Protection in Descending and Thoracoabdominal Aortic Repair (JASPAR) registry. Methods Between January 2000 and October 2011, 2435 descending/thoracoabdominal aortic repairs were performed, including 1998 elective repairs and 437 urgent repairs, in 14 major centers in Japan. The mean patient age was 67 ± 13 years, and 74.2% were males. There were 1471 open repairs (ORs), including 748 descending and 137 thoracoabdominal extent [Ex] I, 136 Ex II, 194 Ex III, 115 Ex IV, and 138 Ex V, and 964 endovascular repairs (EVRs). Of the 2435 patients, 1252 (51%) underwent preoperative magnetic resonance or computed tomography angiography to identify the AKA. Results The AKA was identified in 1096 of the 1252 patients who underwent preoperative imaging (87.6%). Hospital mortality was 9.2% (n = 136) in those who underwent OR and 6.4% (n = 62) in those who underwent EVR. The incidence of SCI was 7.3% in the OR group (descending, 4.2%; Ex I, 9.4%; Ex II, 14.0%; Ex III, 14.4%; Ex IV, 4.2 %; Ex V, 7.2%) and 2.9% in the EVR group. The risk factors for SCI in ORs were advanced age, extended repair, emergency, and occluded bilateral hypogastric arteries. In ORs of the aortic segment involving the AKA, having no AKA reconstruction was a significant risk factor for SCI (odds ratio, 2.79, 95% confidence interval, 1.14-6.79; P = .024). Conclusions In descending/thoracoabdominal aortic repairs, preoperative AKA identification with its adequate reconstruction or preservation, especially, in ORs of aortic pathologies involving the AKA, would be a useful adjunct for more secure spinal cord protection.
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- 2016
55. Successful Acute Endovascular Therapy of Cerebral Embolism for a Patient with Ventricle-assist Device: Case Report
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Kiyohiro Houkin, Toshiya Osanai, Michiyuki Miyamoto, Kanako C. Hatanaka, Tomonori Ooka, Satoshi Ushikochi, Yusuke Shimoda, Satoshi Kobayashi, and Yoshiro Matsui
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medicine.medical_specialty ,business.industry ,Penumbra ,Endovascular therapy ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Cerebral embolism ,Ventricle ,Internal medicine ,Cardiology ,Medicine ,030212 general & internal medicine ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Published
- 2016
56. Modified Right Ventricular Obliteration Technique for Fontan Candidates with Non-functional Right Ventricle
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Hidetsugu Asai, Tsuyoshi Tachibana, Yasushige Shingu, Satoru Wakasa, Tomonori Oooka, and Yoshiro Matsui
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- 2016
57. Modified total cavopulmonary shunt as a staged Fontan operation
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Yoshiro Matsui, Hidetsugu Asai, Satoru Wakasa, Yasushige Shingu, Hiroki Kato, and Tsuyoshi Tachibana
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Salvage therapy ,Vena Cava, Inferior ,Hepatic Veins ,Pulmonary Artery ,030204 cardiovascular system & hematology ,Fontan Procedure ,Inferior vena cava ,Hypoplastic left heart syndrome ,Bidirectional Glenn procedure ,Fontan procedure ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Internal medicine ,Hypoplastic Left Heart Syndrome ,medicine ,Humans ,cardiovascular diseases ,Cavopulmonary shunt ,business.industry ,Heart Bypass, Right ,Infant, Newborn ,Infant ,Recovery of Function ,General Medicine ,medicine.disease ,Surgery ,Treatment Outcome ,030228 respiratory system ,medicine.vein ,Pulmonary artery ,Ventricular Function, Right ,cardiovascular system ,Cardiology ,Azygos vein ,Cardiology and Cardiovascular Medicine ,business - Abstract
The left superior vena cava became occluded in an infant with hypoplastic left heart syndrome. After a bidirectional Glenn procedure, he presented with severe oxygen desaturation and right ventricular dysfunction; the left superior vena cava drained into the inferior vena cava through collateral veins. As salvage therapy, we created a modified total cavopulmonary shunt using only autologous tissue in which the right hepatic vein and inferior vena cava drained into the pulmonary artery via a lateral tunnel in the right atrium. Immediately after surgery, his oxygen saturation increased and right ventricular function improved.
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- 2017
58. Preclinical investigation of folate receptor-targeted nanoparticles for photodynamic therapy of malignant pleural mesothelioma
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Licun Wu, Tatsuya Kato, Hsin-pei Hu, Hironobu Wada, Brian C. Wilson, Marc de Perrot, Gang Zheng, Daiyoon Lee, Yoshihiro Matsuno, Kanako C. Hatanaka, Hiromi Kanno, Yutaka Hatanaka, Rober A. Weersink, Juan Chen, Cheng S. Jin, Kichizo Kaga, Kosuke Fujino, Yoshiro Matsui, Kazuhiro Yasufuku, and Hideki Ujiie
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Male ,Mesothelioma ,0301 basic medicine ,Cancer Research ,Lung Neoplasms ,medicine.medical_treatment ,Cell ,Photodynamic therapy ,0302 clinical medicine ,Epidermal growth factor ,EGFR- tyrosine kinase inhibitors ,folate receptor 1 ,Articles ,Middle Aged ,porphysome ,Lipids ,ErbB Receptors ,Treatment Outcome ,epidermal growth factor ,medicine.anatomical_structure ,photodynamic therapy ,Oncology ,Folate receptor ,030220 oncology & carcinogenesis ,EGFRtyrosine kinase inhibitors ,Female ,Folate receptor 1 ,Adult ,Porphyrins ,Pleural Neoplasms ,Mice, Nude ,Antineoplastic Agents ,Biology ,EGFR-tyrosine kinase inhibitors ,Erlotinib Hydrochloride ,03 medical and health sciences ,In vivo ,Cell Line, Tumor ,medicine ,Animals ,Humans ,malignant pleural mesothelioma ,Viability assay ,Protein Kinase Inhibitors ,Aged ,Mesothelioma, Malignant ,Xenograft Model Antitumor Assays ,030104 developmental biology ,Photochemotherapy ,Cancer research ,Nanoparticles ,Ex vivo - Abstract
Photodynamic therapy (PDT) following lung- sparing extended pleurectomy for malignant pleural mesothelioma (MPM) has been investigated as a potential means to kill residual microscopic cells. High expression levels of folate receptor 1 (FOLR1) have been reported in MPM; therefore, targeting FOLR1 has been considered a novel potential strategy. The present study developed FOLR1-targeting porphyrin-lipid nanoparticles (folate-porphysomes, FP) for the treatment of PDT. Furthermore, inhibition of activated epidermal growth factor (EGFR)-associated survival pathways enhance PDT efficacy. In the present study, these approaches were combined; FP-based PDT was used together with an EGFR-tyrosine kinase inhibitor (EGFR-TKI). The frequency of FOLR1 and EGFR expression in MPM was analyzed using tissue microarrays. Confocal microscopy and a cell viability assay were performed to confirm the specificity of FOLR1-targeting cellular uptake and photocytotoxicity in vitro. In vivo fluorescence activation and therapeutic efficacy were subsequently examined. The effects of EGFR-TKI were also assessed in vitro. The in vivo combined antitumor effect of EGFR-TKI and FP-PDT was then evaluated. The results revealed that FOLR1 and EGFR were expressed in 79 and 89% of MPM samples, respectively. In addition, intracellular uptake of FP corresponded well with FOLR1 expression. When MPM cells were incubated with FP and then irradiated at 671 nm, there was significant in vitro cell death, which was inhibited in the presence of free folic acid, thus suggesting the specificity of FPs. FOLR1 targeting resulted in disassembly of the porphysomes and subsequent fluorescence activation in intrathoracic disseminated MPM tumors, as demonstrated by ex vivo tissue imaging. FP-PDT resulted in significant cellular damage and apoptosis in vivo. Furthermore, the combination of pretreatment with EGFR-TKI and FP-PDT induced a marked improvement of treatment responses. In conclusion, FP-based PDT induced selective destruction of MPM cells based on FOLR1 targeting, and pretreatment with EGFR-TKI further enhanced the therapeutic response.
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- 2018
59. Re-do mitral valve replacement for a bioprosthetic valve with central transvalvular leakage in a patient with ischemic cardiomyopathy: a case report
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Hiroki Katoh, Yasushige Shingu, Suguru Kubota, Tatsuya Seki, Tsuyoshi Tachibana, Satoru Wakasa, Tomonori Ooka, and Yoshiro Matsui
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Cardiac function curve ,Male ,Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,Biomedical Engineering ,Cardiac index ,Myocardial Ischemia ,Medicine (miscellaneous) ,Biomaterials ,Transvalvular leakage ,Internal medicine ,medicine ,Humans ,Pulmonary wedge pressure ,Papillary muscle ,Aged ,Bioprosthesis ,Heart Valve Prosthesis Implantation ,Ischemic cardiomyopathy ,Mechanical valve ,business.industry ,Mitral valve replacement ,Mitral Valve Insufficiency ,Papillary Muscles ,medicine.disease ,Cardiac surgery ,Prosthesis Failure ,medicine.anatomical_structure ,Bioprosthetic valve ,Echocardiography ,Heart Valve Prosthesis ,Cardiology ,Mitral Valve ,Cardiology and Cardiovascular Medicine ,business ,Mitral valve regurgitation - Abstract
Transvalvular leakage (TVL) of a prosthetic heart valve is not negligible regurgitant flow in patients with critically low contractile function. Although the opening function of prosthetic valves has been reported, its closing function is not well understood. A man in his 70s had a history of mitral valve replacement (MVR) with a Magna Mitral (R) valve for ischemic mitral valve regurgitation. He presented with dyspnea 2 years postoperatively. Echocardiography showed moderate TVL. The pulmonary capillary wedge pressure and cardiac index were 37mmHg and 1.65L/min/m(2), respectively. Because we considered his TVL relevant, we performed re-do MVR with a mechanical valve and papillary muscle approximation and suspension (papillary muscle tugging approximation). His cardiac function improved postoperatively; he was discharged with New York Heart Association class I. For MVR in patients with critically low contractile function, prosthetic valves, such as mechanical valves, with small TVL are recommended.
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- 2018
60. Mechanical properties of a new thermally deformable mitral valve annuloplasty ring and its effects on the mitral valve
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Tomonori Ooka, Tsuyoshi Tachibana, Toshiro Ohashi, Yasushige Shingu, Hiroki Katoh, Satoru Wakasa, Katsuyoshi Jimuro, Yoshiro Matsui, Tatsuya Seki, and Suguru Kubota
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medicine.medical_specialty ,Materials science ,Hot Temperature ,Mitral Valve Annuloplasty ,Swine ,Systole ,medicine.medical_treatment ,0206 medical engineering ,Finite Element Analysis ,Biomedical Engineering ,Medicine (miscellaneous) ,02 engineering and technology ,030204 cardiovascular system & hematology ,Deformation (meteorology) ,Ring (chemistry) ,Prosthesis Design ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Mitral valve annuloplasty ,Mitral valve ,Materials Testing ,medicine ,Animals ,cardiovascular diseases ,Mitral valve repair ,Annulus (oil well) ,Minimum distance ,Mitral Valve Insufficiency ,020601 biomedical engineering ,Cardiac surgery ,Polycaprolactone ,medicine.anatomical_structure ,Mitral valve annuloplasty ring ,Heart Valve Prosthesis ,cardiovascular system ,Mitral Valve ,Cardiology and Cardiovascular Medicine ,Biomedical engineering - Abstract
Ideally, an annuloplasty ring’s shape should be changed intraoperatively if mitral valve repair is unsuccessful because of a short coaptation length or systolic anterior motion. Several post-implantation adjustable rings have been developed, but they are not freely deformable and are unsuitable for asymmetric repair of the valvular annulus. We developed a novel thermally deformable mitral annuloplasty ring to address these problems and assessed the ring’s mechanical properties and its effect on the mitral valve anatomy. This ring was made of polycaprolactone. Tensile and bending tests were performed to evaluate the ring’s mechanical properties. The ratio of the transverse and septal–lateral length was determined as 4:3. Using 10 pig hearts, we measured the post-deformation coaptation length and minimum distance from the coaptation to the ventricular septum, which is a factor of abnormal systolic anterior motion of the mitral valve. In the mechanical tests, the ring’s yield point was greater than the deformation force of the annulus in humans. In pigs with deformation from “4:3” to “4:2”, the coaptation length was significantly increased in each mitral valve part. In pigs with deformation from “4:3” to “4:4”, the minimum distance from the coaptation to the ventricular septum was significantly increased. Asymmetrical ring deformation increased the coaptation length only at the deformed area. In conclusion, this new thermally deformable mitral annuloplasty ring could be “order-made” to effectively change the coaptation length in all parts of the mitral valve and the distance from the coaptation to septum post-deformation via intraoperative heating.
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- 2018
61. [Surgical Options for Refractory Heart Failure Patients with Non-ischemic Dilated Cardiomyopathy]
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Yasushige, Shingu, Tomonori, Ooka, Tsuyoshi, Tachibana, Suguru, Kubota, and Yoshiro, Matsui
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Cardiomyopathy, Dilated ,Heart Failure ,Treatment Outcome ,Heart Ventricles ,Heart Transplantation ,Humans ,Mitral Valve Insufficiency ,Heart-Assist Devices ,Papillary Muscles - Abstract
Surgical strategy for non-ischemic dilated cardiomyopathy (NIDCM) is currently controversial. Subjects were 20 patients who underwent left ventriculoplasty(LVP) from 2006 to 2013 and 6 patients who underwent papillary muscle tugging approximation (PMTA) after 2015. PMTA is a new trans-mitral approach combined with valve replacement without left ventriculotomy. Another group of patients( n=14)who were registered for heart transplantation( HTx) after 2013 was also analyzed for left ventricular assist device(LVAD) free survival. Mw( slope in the preload recruitable stroke work relationship) calculated by single beat technique using echocardiography was employed as a load-independent cardiac functional parameter. The baseline characteristics and Mw were not different between the LVP and PMTA groups. One-year survival was significantly lower in the LVP group(53%)than in the PMTA group(100%)[log-rank:p=0.024]. In the HTx group, early LVAD implantation was necessary in the patients who had low Mw(20)at the time of registration. In conclusion, PMTA would be one option for NIDCM patients( non-HTx candidates) with severe mitral regurgitation. Early LVAD implantation might be predicted in HTx candidates with low Mw(20).
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- 2018
62. Supravalvular aortic stenosis with a chronic type A aortic dissection
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Takahiro Ishigaki, Yasushige Shingu, and Yoshiro Matsui
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Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Computed Tomography Angiography ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Blood Vessel Prosthesis Implantation ,0302 clinical medicine ,Aneurysm ,medicine ,Humans ,Computed tomography angiography ,Aortic dissection ,Heart Failure ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Plastic Surgery Procedures ,medicine.disease ,Aortic Aneurysm ,Aortic Stenosis, Supravalvular ,Aortic Dissection ,Chronic disease ,030228 respiratory system ,Chronic Disease ,Surgery ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Supravalvular aortic stenosis ,Vascular Surgical Procedures - Published
- 2018
63. Variations of pulmonary vein drainage critical for lung resection assessed by three-dimensional computed tomography angiography
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Nobuyuki, Shiina, Kichizo, Kaga, Yasuhiro, Hida, Tsukasa, Sasaki, Satoshi, Hirano, and Yoshiro, Matsui
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Male ,pulmonary vein ,Lung Neoplasms ,Computed Tomography Angiography ,Thoracic Surgery, Video-Assisted ,anomaly ,Original Articles ,Pulmonary Surgical Procedures ,Pulmonary Veins ,Drainage ,Humans ,Female ,Original Article ,Lymph Nodes ,Anatomy ,Tomography, X-Ray Computed ,video‐assisted thoracoscopic surgery ,Lung ,three‐dimensional CT angiography - Abstract
Background It is important to understand pulmonary vein drainage pattern variations and their frequency in order to perform safe anatomical pulmonary resection. Methods Variations and frequencies were assessed using three‐dimensional computed tomography angiography (3D‐CT) in 194 patients. In cases where the tumor or lymph node caused atelectasis or compression of hilar structures, the involved lobes were excluded from the analyses. Results We confirmed variant drainage patterns in 15/189 (8.0%) patients in the right upper lobe (RUL), 29/189 (15.3%) in the right middle lobe (RML), 18/192 (9.5%) in the right lower lobe (RLL), and 5/187 (2.6%) in the left upper lobe (LUL). There was no variant type in the left lower lobe (LLL). There were 14 (7.4%) cases of anomalous superior posterior pulmonary vein of RUL (V2) drainage: V2 draining to the superior pulmonary vein (SPV) (n = 2, 1.1%), V2 to the inferior pulmonary vein (IPV) (n = 7, 3.7%), V2 to the left atrium (LA) (n = 2, 1.1%), and V6 to the apical pulmonary vein of the RLL (n = 3, 1.6%). There was a posterior pulmonary vein, V3 to RML pulmonary vein in one case (0.5%). The RML pulmonary vein drained into the IPV in 14 (7.4%) and into the LA in 15 (7.9%) cases. The right V6 directly drained into the LA in 15 (7.9%) and V6 into the SPV in 3 (1.6%) cases. The lingular pulmonary vein drained into the IPV in one case (0.5%) and into the LA in two cases (1.1%). The inferior lingular pulmonary vein V5 drained into the IPV and into the LA in one case (0.5%), respectively. Conclusion We describe anomalous pulmonary venous drainage patterns and their frequencies particular to anatomic surgical resection. 3D‐CT is useful to find such variations.
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- 2018
64. Prognostic value of MAGEA4 in primary lung cancer depends on subcellular localization and p53 status
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Takehiro Noji, Kimitaka Tanaka, Yasuhiro Hida, Hiroaki Ikeda, Aki Fujiwara-Kuroda, Hiroshi Shiku, Yoshiro Matsui, Noriaki Kyogoku, Takehiro Abiko, Tatsuya Kato, Kichizo Kaga, Satoshi Hirano, Shinichi Kageyama, Masaomi Ichinokawa, and Takahiro Tsuchikawa
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p53 ,0301 basic medicine ,Male ,Cancer Research ,Cytoplasm ,Lung Neoplasms ,melanoma antigen family A4 ,medicine.medical_treatment ,Cell ,Biology ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Antigen ,Antigens, Neoplasm ,Cell Line, Tumor ,subcellular localization ,medicine ,Animals ,Humans ,Lung cancer ,non-small cell lung cancer ,Cell Nucleus ,tissue microarray ,Oncogene ,apoptosis ,Cancer ,Immunotherapy ,Cell cycle ,medicine.disease ,Prognosis ,Survival Analysis ,Neoplasm Proteins ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Apoptosis ,Tissue Array Analysis ,030220 oncology & carcinogenesis ,Cancer research ,Female ,Tumor Suppressor Protein p53 ,Neoplasm Transplantation - Abstract
Melanoma antigen family A4 (MAGEA4), a cancer/testis antigen, is overexpressed and is thus an immunotherapy target in various malignant tumors, including non-small cell lung cancer. However, whether MAGEA4 induces or inhibits the apoptosis of lung cancer cells remains controversial, as is its prognostic significance, particularly since there is no reliable method with which to detect MAGEA4 specifically. In this study, we optimized assay conditions to detect MAGEA4 based on cells transiently transfected with MAGEA genes, and found that MAGEA4 was expressed in four of eight non-small cell lung cancer cell lines, and in 25.4% of clinical lung cancer specimens. We also found that MAGEA4 overexpression decreased apoptosis, as measured by the levels of cleaved caspase-3 in stably transfected 293F cells. Notably, patients with nuclear MAGEA4, but not p53 expression exhibited a significantly poorer survival than those expressing both nuclear MAGEA4 and p53. Indeed, multivariate analysis identified nuclear MAGEA4 as an independent prognostic factor (P=0.0042), albeit only in the absence of p53. In this study, to the best of our knowledge, we are the first to demonstrate that the function and prognostic value of MAGEA4 depends on its subcellular localization and on the p53 status.
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- 2017
65. The significance of the analysis on scalographic pattern for detecting malfunctioning bileaflet valve with the wavelet analysis
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Yasushige Shingu, Tomonori Ooka, Hiroshi Sugiki, Yoshiro Matsui, Kenji Sugiki, Satoru Wakasa, and Tsuyoshi Tachibana
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0206 medical engineering ,Wavelet Analysis ,Biomedical Engineering ,Medicine (miscellaneous) ,02 engineering and technology ,030204 cardiovascular system & hematology ,Prosthesis Design ,Mechanical heart-valve ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Wavelet ,Humans ,Prosthesis design ,Cutoff ,Single spike ,Mathematics ,Prosthetic valve ,business.industry ,Pattern recognition ,020601 biomedical engineering ,Prosthesis Failure ,Heart Valve Prosthesis ,Spike (software development) ,Artificial intelligence ,Cutoff point ,Cardiology and Cardiovascular Medicine ,business ,Biomedical engineering - Abstract
The authors developed the wavelet analysis system which can detect the splitting of bileaflet mechanical heart valve (BLV) into two spikes on the scalogram, and reported that either consecutive single spike or the split behavior can detect malfunctioning BLV (MBV). The latest study on 12 BLVs suggested that the comparison between two spike areas showed higher potential to detect MBV than the split behavior. The aim of the current study is to review 226 files of BLV sound and to select the suitable scalographic property to differentiate the function of BLV with the split. Eight of 30 MBV files showed consecutive single spike, and the rest of 22 MBV files showed two spikes. Two spike areas can be compared by the following three ratios; the anterior spike area/posterior spike area (Aa/La), its reverse ratio (Pa/Aa) and the smaller spike area/the larger spike ratio (Sa/La). Therefore, the current study compared those three ratios to pursue the suitable ratio to compare two spike areas and its sensitivity to differentiate valve function by the ROC analysis. As a result, the Sa/La was suitable for comparing two spike areas, and only this ratio showed high accuracy to differentiate the function of BVL with the split, and its cutoff value was
- Published
- 2015
66. Effects of body mass index (BMI) on surgical outcomes: a nationwide survey using a Japanese web-based database
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Hiroyuki Konno, Shinichi Takamoto, Susumu Aikou, Masahiro Takeuchi, Yasuyuki Seto, Yoshiki Sawa, Mitsukazu Gotoh, Hiroaki Miyata, Noboru Motomura, Masaki Mori, Kohei Akazawa, Norihiro Kokudo, Yoshiro Matsui, Hiroyuki Kuwano, and Motonari Ri
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Male ,medicine.medical_specialty ,Databases, Factual ,medicine.medical_treatment ,Operative Time ,Body Mass Index ,Japan ,Thinness ,Aortic valve replacement ,Risk Factors ,medicine.artery ,Humans ,Medicine ,Thoracic aorta ,Obesity ,Digestive System Surgical Procedures ,Internet ,business.industry ,Cardiovascular Surgical Procedures ,Mortality rate ,General Medicine ,Pancreaticoduodenectomy ,medicine.disease ,Surgery ,Survival Rate ,Treatment Outcome ,Esophagectomy ,Female ,Gastrectomy ,Underweight ,medicine.symptom ,business ,Body mass index - Abstract
To define the effects of body mass index (BMI) on operative outcomes for both gastroenterological and cardiovascular surgery, using the National Clinical Database (NCD) of the Japanese nationwide web-based database. The subjects of this study were 288,418 patients who underwent typical surgical procedures between January 2011 and December 2012. There were eight gastroenterological procedures, including esophagectomy, distal gastrectomy, total gastrectomy, right hemicolectomy, low anterior resection, hepatectomy of >1 segment excluding the lateral segment, pancreaticoduodenectomy, and surgery for acute diffuse peritonitis (n = 232,199); and five cardiovascular procedures, including aortic valve replacement, total arch replacement (TAR), descending thoracic aorta replacement (descending TAR), and on- or off-pump coronary artery bypass grafting (n = 56,219). The relationships of BMI with operation time and operative mortality for each procedure were investigated, using the NCD. Operation times were longer for patients with a higher BMI. When a BMI cut-off of 30 was used, the operation time for obese patients was significantly longer than that for non-obese patients, for all procedures except esophagectomy (P
- Published
- 2015
67. Slope in preload recruitable stroke work relationship predicts survival after left ventriculoplasty and mitral repair in patients with idiopathic cardiomyopathy
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Tsuyoshi Tachibana, Yoshiro Matsui, Hiroki Kato, Suguru Kubota, Satoru Wakasa, Yasushige Shingu, and Tomonori Ooka
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Adult ,Cardiomyopathy, Dilated ,Male ,medicine.medical_specialty ,Mitral Valve Annuloplasty ,Cardiomyopathy ,Heart Ventricles ,Sensitivity and Specificity ,Cardiomyopath ,Predictive Value of Tests ,Internal medicine ,Mitral valve ,Idiopathic dilated cardiomyopathy ,medicine ,Humans ,Cardiac Output ,Idiopathic Cardiomyopathy ,Aged ,Mitral regurgitation ,Heart Failure ,Heart Valve Prosthesis Implantation ,Ejection fraction ,business.industry ,Mitral Valve Insufficiency ,Middle Aged ,medicine.disease ,Survival Rate ,Preload ,medicine.anatomical_structure ,Echocardiography ,Heart failure ,Cardiology ,Female ,Surgery ,business ,Cardiology and Cardiovascular Medicine - Abstract
Background Left ventriculoplasty (LVP) and mitral valve plasty (MVP) are sometimes effective for patients with idiopathic dilated cardiomyopathy (DCM) who are not eligible for heart transplantation. Strict patient selection is warranted for these controversial procedures. Methods and results The subjects were 18 patients with idiopathic DCM and mitral regurgitation who had not been indicated for heart transplantation due to either older age or patient refusal, and who underwent LVP and MVP. Their mean age was 57 ± 14 years and 50% were dependent on catecholamine infusion. The preload recruitable stroke work (PRSW) relationship and its slope (Mw) were estimated by a single-beat technique using transthoracic echocardiography. There were one 30-day mortality and six (33%) hospital deaths due to heart failure. The one-year survival rate was 50%. Left ventricular end-diastolic dimension (LVDd) decreased from 77 ± 11 to 68 ± 11 mm (p = 0.001) whereas the ejection fraction did not change. Preoperative Mw was significantly higher in one-year survivors than that in non-survivors (54 ± 17 erg cm−3 103 vs. 31 ± 10 erg cm−3 103, p = 0.005). Preoperative LVDd was not different between the groups. The cut-off value of 42 erg cm−3 103 for Mw predicted one-year survival with high sensitivity (100%) and specificity (77%). Conclusions Mw, the slope in the PRSW relationship, may predict survival after LVP and MVP in patients with idiopathic DCM.
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- 2015
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68. Surgical Strategy for Ischemic Mitral Regurgitation Adopting Subvalvular and Ventricular Procedures
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Tomonori Ooka, Satoru Wakasa, Yoshiro Matsui, Hiroki Katoh, Tsuyoshi Tachibana, and Yasushige Shingu
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Adult ,Male ,Reoperation ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Mitral Valve Annuloplasty ,medicine.medical_treatment ,Cardiomyopathy ,Coronary Artery Disease ,Kaplan-Meier Estimate ,Preoperative care ,Coronary artery disease ,Recurrence ,Internal medicine ,Mitral valve ,Preoperative Care ,Humans ,Medicine ,cardiovascular diseases ,Papillary muscle ,Aged ,Retrospective Studies ,Aged, 80 and over ,Heart Valve Prosthesis Implantation ,Postoperative Care ,Mitral regurgitation ,Mitral valve repair ,Ejection fraction ,business.industry ,Gastroenterology ,Mitral Valve Insufficiency ,General Medicine ,Middle Aged ,Papillary Muscles ,medicine.disease ,Treatment Outcome ,medicine.anatomical_structure ,cardiovascular system ,Cardiology ,Female ,Original Article ,Surgery ,Erratum ,Cardiomyopathies ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Purpose: The progression of left ventricular (LV) remodeling and subsequent mitral valve tethering impair the results of reduction annuloplasty for ischemic mitral regurgitation (MR). Methods: We studied 90 patients who underwent surgical repair of ischemic MR between 1999 and 2013 according to our surgical strategy adding submitral and ventricular procedures to annuloplasty as follows: annuloplasty alone (stage 1, n = 30), additional papillary muscle approximation (PMA) for progression of tethering (stage 2, n = 26), and additional left ventriculoplasty with PMA for progression of LV remodeling and tethering (stage 3, n = 34). Results: The preoperative New York Heart Association (NYHA) functional classes (2.5 ± 0.7, 3.1 ± 0.7 and 3.3 ± 0.7 for stages 1, 2 and 3, respectively, P
- Published
- 2015
69. Clinical Results, Adverse Events, and Change in End-Organ Function in Elderly Patients With HeartMateII Left Ventricular Assist Device - Japanese Multicenter Study
- Author
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Minoru Ono, Yoshiro Matsui, Yoshikatsu Saiki, Akihiko Usui, Daisuke Yoshioka, Hirokuni Arai, Hiroshi Niinami, Koichi Toda, Takeshi Nakatani, Kenji Yamazaki, Yoshiki Sawa, Goro Matsumiya, and Akira Shiose
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Heart Ventricles ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Japan ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Renal Insufficiency ,Risk factor ,Adverse effect ,Stroke ,business.industry ,Incidence (epidemiology) ,Incidence ,General Medicine ,Recovery of Function ,Middle Aged ,medicine.disease ,Treatment Outcome ,Ventricular assist device ,Cohort ,Cardiology ,Female ,Heart-Assist Devices ,Cardiology and Cardiovascular Medicine ,business ,Destination therapy - Abstract
Background Advanced age has an adverse impact on clinical results in left ventricular assist device (LVAD) patients. We compared the clinical results of patients aged >60 years with younger patients using a national Japanese database.Methods and Results:Between April 2013 and December 2016, 300 patients underwent HeartMateII implantation. Of these, 37 patients were ≥60 years at LVAD implantation, and the clinical results of these patients were compared with the other younger 263 patients. At 1 and 3 years the on-device survival was 95%, 91% in younger patients, and 85%, 75% in older patients, respectively (P=0.016), although age was not a risk factor on the multivariate analysis. There was no significant difference between the groups in incidence of various adverse events except stroke. In the propensity-matching cohort, the incidence of stroke was significantly higher in patients aged >60 years (P=0.047). In patients aged >60 years, improvement of renal function was transient and there was no improvement later than 3 months, and recovery of serum albumin level to preoperative value was delayed. Conclusions There were significant differences in the stroke incidence and recovery of end-organ functions after LVAD implantation. This may have important implications for patient selection in future destination therapy in Japan, where quality of life is an important issue in LVAD support.
- Published
- 2017
70. Anticoagulation management during cardiopulmonary bypass in patients with antiphospholipid syndrome
- Author
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Hiroki Katoh, Hiroshi Sugiki, Tomonori Ooka, Tatsuya Seki, Yasushige Shingu, Suguru Kubota, Tsuyoshi Tachibana, Yoshiro Matsui, and Satoru Wakasa
- Subjects
Nephrology ,medicine.medical_specialty ,Biomedical Engineering ,Activated clotting time ,Medicine (miscellaneous) ,030204 cardiovascular system & hematology ,law.invention ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,law ,Antiphospholipid syndrome ,Internal medicine ,medicine ,Cardiopulmonary bypass ,Humans ,In patient ,skin and connective tissue diseases ,Blood Coagulation ,Autoimmune disease ,Cardiopulmonary Bypass ,medicine.diagnostic_test ,business.industry ,Heparin ,Anticoagulants ,Mitral Valve Insufficiency ,Thrombosis ,Middle Aged ,medicine.disease ,Antiphospholipid Syndrome ,Cardiac surgery ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Antiphospholipid syndrome (APS) is a complex autoimmune disease often related to systemic lupus erythematosus. Although adequate anticoagulation is important for APS patients during cardiopulmonary bypass, clotting tests can be potentially misleading due to antiphospholipid antibodies. We performed cardiac surgery safely in two APS patients under anticoagulation monitoring determined using preoperative heparin titration. We performed heparin titration for activated clotting time to determine the appropriate heparin concentration during cardiac surgery. We changed the targeted heparin concentration considering each patient’s thrombotic risks: 3 U/ml of heparin for a normal-risk APS patient and 5 U/ml for a high-risk APS patient with a history of antiphospholipid-antibody-associated thrombocytopenia. A higher targeted heparin concentration might be necessary for patients with high thrombotic risks.
- Published
- 2017
71. [Perioperative Care of Low Cardiac Output Syndrome]
- Author
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Hiroki, Kato and Yoshiro, Matsui
- Subjects
Cardiopulmonary Bypass ,Regional Blood Flow ,Cardiac Output, Low ,Heart Arrest, Induced ,Myocardial Revascularization ,Humans ,Heart-Assist Devices ,Perioperative Care - Abstract
Low cardiac syndrome( LOS) is the imbalance of the oxygen supply and demand at the tissue due to reduced oxygen supply by decreased cardiac function. The causes of the cardiac dysfunction are insufficient cardioplegia, elongation of aortic clamp or cardiopulmonary bypass (CPB) duration, incomplete revascularization, and so on. The preventions of LOS are myocardial protections intraoperatively. The most important myocardial protection is to accomplish more quickly, accurately and safety to operation. And today, cardioplegia is essential for surgery requiring CPB. The integrated myocardia protection is likely to be effective to the patients who suffer low cardiac function. LOS is commonly defined the decreased cardiac index (CI)[2.0~2.2 l/min/m2], systolic blood pressure (80~90 mmHg) and the signs of tissue malperfusion, in the absence of hypovolemia. The treatment of LOS is, at first, the correction of hypovolemia, then rhythm control, adjustment of preload and afterload. When it does not recover from LOS despite adequate treatment, the mechanical circulatory assist devices should be introduced without hesitation.
- Published
- 2017
72. The Social Science of International Law: Its Evolution in Japan
- Author
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Yoshiro Matsui
- Subjects
Law ,Political science ,International law - Published
- 2017
73. Feasibility and limitations of mitral valve repair, with or without left ventricular reconstruction in non-ischemic dilated cardiomyopathy
- Author
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Tomonori Ooka, Suguru Kubota, Yasushige Shingu, Hiroki Katoh, Yoshiro Matsui, and Tsuyoshi Tachibana
- Subjects
Adult ,Cardiomyopathy, Dilated ,Male ,medicine.medical_specialty ,Mitral Valve Annuloplasty ,medicine.medical_treatment ,Heart Ventricles ,Cardiac index ,Cardiac Output, Low ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Internal medicine ,medicine ,Humans ,Longitudinal Studies ,Postoperative Period ,Mitral regurgitation ,Aged ,Retrospective Studies ,Heart Failure ,Mitral valve repair ,Ejection fraction ,business.industry ,Mitral Valve Insufficiency ,Dilated cardiomyopathy ,Stroke Volume ,Stroke volume ,Middle Aged ,medicine.disease ,Non-ischemic dilated cardiomyopathy ,Survival Rate ,Preload ,030228 respiratory system ,Echocardiography ,Heart failure ,cardiovascular system ,Cardiology ,Feasibility Studies ,Mitral Valve ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Although non-transplant surgical interventions for non-ischemic dilated cardiomyopathy (NIDCM) are relatively effective, their feasibility and limitations have not been fully elucidated. The aim of this study was to define the feasibility and limitations of mitral valve repair, with or without surgical ventricular reconstruction for patients with NIDCM in terms of postoperative low cardiac output syndrome (LOS). Methods Twenty non-transplant candidates (aged 57 ± 13 years) with NIDCM and significant mitral regurgitation had undergone mitral valve repair combined with submitral procedures. Using a 72-mL plastic ellipsoidal sizer, left ventricular reconstruction was performed concomitantly in 14/20 (70%) patients with extremely large ventricles. Total stroke volume, deceleration time of early trans-mitral flow wave, and the slope (Mw) in the preload recruitable stroke-work relationship were assessed using transthoracic echocardiography. LOS was defined as in-hospital death due to heart failure or a cardiac index less than 2.2 L/min/m2 before discharge. Results There were three in-hospital deaths and four patients with postoperative cardiac index less than 2.2 L/min/m2 [n = 7 (35%), LOS group]. Preoperative total stroke volume, deceleration time, and the Mw were significantly lower in the LOS group compared to those in the non-LOS group; the predicted cut-off values for LOS were 84 mL/beat (p = 0.008), 133 ms (p = 0.015), and 45 erg cm−3 × 103 (p = 0.036), respectively. Preoperative left ventricular ejection fraction and ventricular size could not predict postoperative LOS. The one-year survival rate was 0% in the LOS group and 84% in the non-LOS group (p Conclusions Mitral valve repair, with or without left ventricular reconstruction, could be contraindicated for NIDCM patients with low total stroke volume, deceleration time, and Mw in terms of high postoperative incidence of LOS. For high-risk patients, other therapeutic strategies might be necessary.
- Published
- 2017
74. Folate receptor targeted PDT in lung cancer
- Author
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Hironobu Wada, Gang Zheng, Hideki Ujiie, Tatsuya Kato, Daiyoon Lee, Kichizo Kaga, Kosuke Fujino, Brian C. Wilson, Robert A. Weersink, Mitsuhito Kaji, Cheng S. Jin, Juan Chen, Yoshiro Matsui, Kazuhiro Yasufuku, and Hsin-pei Hu
- Subjects
0301 basic medicine ,Pulmonary and Respiratory Medicine ,Cancer Research ,Pathology ,medicine.medical_specialty ,Lung Neoplasms ,Porphyrins ,medicine.medical_treatment ,Mice, Nude ,Photodynamic therapy ,photodynamic therapy (PDT) ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Folate Receptor 1 ,Viability assay ,Lung cancer ,Lymph node ,A549 cell ,Lung ,business.industry ,folate receptor 1 (FOLR1) ,respiratory system ,porphysome ,medicine.disease ,Lipids ,Xenograft Model Antitumor Assays ,Tumor Burden ,lung cancer ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Photochemotherapy ,A549 Cells ,030220 oncology & carcinogenesis ,Lymphatic Metastasis ,Nanoparticles ,Female ,Folate receptor 1 ,business - Abstract
Objective Despite modest improvements, the prognosis of lung cancer patients has still remained poor and new treatment are urgently needed. Photodynamic therapy (PDT), the use of light-activated compounds (photosensitizers) is a treatment option but its use has been restricted to central airway lesions. Here, we report the use of novel porphyrin-lipid nanoparticles (porphysomes) targeted to folate receptor 1 (FOLR1) to enhance the efficacy and specificity of PDT that may translate into a minimally-invasive intervention for peripheral lung cancer and metastatic lymph nodes of advanced lung cancer. Materials and methods The frequency of FOLR1 expression in primary lung cancer and metastatic lymph nodes was first analyzed by human tissue samples from surgery and endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA). Confocal fluorescence microscopy was then used to confirm the cellular uptake and fluorescence activation in lung cancer cells, and the photocytotoxicity was evaluated using a cell viability assay. In vivo fluorescence activation and quantification of uptake were investigated in mouse lung orthotopic tumor models, followed by the evaluation of in vivo PDT efficacy. Results FOLR1 was highly expressed in metastatic lymph node samples from patients with advanced lung cancer and was mainly expressed in lung adenocarcinomas in primary lung cancer. Expression of FOLR1 in lung cancer cell lines corresponded with the intracellular uptake of folate-porphysomes in vitro. When irradiated with a 671 nm laser at a dose of 10 J/cm2, folate-porphysomes showed marked therapeutic efficacy compared with untargeted porphysomes (28% vs. 83% and 24% vs. 99% cell viability in A549 and SBC5 lung cancer cells, respectively). Systemically-administered folate-porphysomes accumulated in lung tumors with significantly enhanced disease-to-normal tissue contrast. Folate-porphysomes mediated PDT successfully inhibited tumor cell proliferation and activated tumor cell apoptosis. Conclusion Folate-porphysome based PDT shows promise in selectively ablating lung cancer based on FOLR1 expression in these preclinical models.
- Published
- 2017
75. Decreased gene expression of fatty acid binding protein 3 in the atrium of patients with new onset of atrial fibrillation in cardiac perioperative phase
- Author
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Tomonori Ooka, Yasushige Shingu, Shingo Takada, Hiroki Katoh, Haruki Niwano, Tsuyoshi Tachibana, Yoshiro Matsui, Suguru Kubota, and Takashi Yokota
- Subjects
Male ,medicine.medical_specialty ,Gene Expression ,030204 cardiovascular system & hematology ,Fatty acid-binding protein ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Internal medicine ,Atrial Fibrillation ,medicine ,Fatty acid binding protein ,Citrate synthase ,Humans ,030212 general & internal medicine ,Heart Atria ,Postoperative Period ,Atrium (heart) ,Cardiac Surgical Procedures ,Aged ,chemistry.chemical_classification ,Aged, 80 and over ,biology ,business.industry ,Fatty acid ,Atrial fibrillation ,Cardiac surgery ,Peroxisome ,Middle Aged ,medicine.disease ,Postoperative atrial fibrillation ,Citric acid cycle ,medicine.anatomical_structure ,chemistry ,Preoperative Period ,cardiovascular system ,biology.protein ,Cardiology ,Fatty Acid Binding Protein 3 ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Post-operative atrial fibrillation (POAF) frequently occurs after cardiac surgery. However, the mechanisms of POAF have not been fully elucidated. We aimed to examine whether pre-operative atrial gene expression related to cardiac metabolism is changed in patients with POAF. Methods Right atrial tissue was obtained during surgery from 38 patients who underwent cardiac surgery from 2013 to 2015. Atrial expression levels were determined by reverse transcription polymerase chain reaction for the following genes: glucose transporter type 4, peroxisome proliferator-activated receptor-α, fatty acid translocase, carnitine palmitoyltransferase 1B, and fatty acid binding protein 3 (FABP3). To investigate fatty acid β-oxidation and tricarboxylic acid cycle capacities in the mitochondria, β-hydroxyacyl CoA dehydrogenase and citrate synthase activity levels were spectrophotometrically determined. Results POAF within 7 days after surgery was observed in 18 (47%) patients. POAF patients were significantly older, had a larger left atrial diameter, and had reduced expression of FABP3, a fatty acids transport gene in the cytosol, compared to those in the non-POAF group. Reduced FABP3 expression predicted POAF independent of age and atrial size. In contrast, fatty acid β-oxidation enzymatic activity was comparable between the groups. Conclusions FABP3 gene expression in the atrium was reduced in patients with POAF. These findings suggest a potential link between altered fatty acid transport in the atrium and increased AF onset after cardiac surgery.
- Published
- 2017
76. Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer
- Author
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Mitsuhito Kaji, Kichizo Kaga, Kosuke Fujino, Hsin-pei Hu, Tatsuya Kato, Hideki Ujiie, Daiyoon Lee, Yoshiro Matsui, and Kazuhiro Yasufuku
- Subjects
p53 ,0301 basic medicine ,Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Adenocarcinoma of Lung ,Biology ,Adenocarcinoma ,medicine.disease_cause ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Cell Line, Tumor ,medicine ,Humans ,Molecular Targeted Therapy ,Lung cancer ,Aged ,Cell Proliferation ,EBUS-TBNA ,Tissue microarray ,Oncogene ,therapeutic target ,Cancer ,Middle Aged ,medicine.disease ,Prognosis ,Molecular medicine ,Neoplasm Proteins ,Gene Expression Regulation, Neoplastic ,lung cancer ,030104 developmental biology ,Cell Transformation, Neoplastic ,030220 oncology & carcinogenesis ,Lymphatic Metastasis ,Cancer cell ,biomarker ,Female ,Tumor Suppressor Protein p53 ,Carcinogenesis ,MAGEA2 ,Melanoma-Specific Antigens - Abstract
Melanoma-associated antigens (MAGE) are expressed in different type of cancers including lung cancer and have been shown to be functionally related to p53 tumor suppressor gene. Little is known about the relationship between MAGE genes and p53 aberrant expression in lung cancer. The aims of this study were to observe the expression of MAGEA2, examine the role of MAGEA2 in lung cancer survival, investigate its correlation between MAGEA2 and p53, and explore its clinicopathologic significance as a prognostic marker. Quantitative reverse transcription-polymerase chain reaction was performed to detect the expression of MAGEA2 using 36primary tumors and 31 metastatic lymph nodes from patients with lung cancer. The role of MAGEA2 in cancer cell growth and in the regulation of p53 downstream genes were examined using small interfering RNA. The expression of MAGEA2 and p53 were analyzed immunohistochemically using tissue microarray from 353 resected lung specimens. High-level expression of MAGEA2 (High-MAGEA2) was confirmed in lung tumors with high frequency. Inhibiting MAGEA2 expression effectively suppressed cancer cell growth and decreased the expression of p53 downstream target genes invitro. In adenocarcinoma, High-MAGEA2 was strongly associated with aberrant p53 expression (P
- Published
- 2017
77. Therapeutic strategy for treating aortoesophageal fistulas
- Author
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Yoshiki Sawa, Hidetoshi Akashi, Hiroyuki Tanaka, Kiyotaka Imoto, Satoru Tobinaga, Shunichi Kondo, Hiromasa Fujita, Suguru Kubota, Tomohiko Sakamoto, Yoshikatsu Saiki, Yutaka Okita, Katsuhiro Yamanaka, Takuro Tsukube, Shunsuke Kawamoto, Norihisa Karube, and Yoshiro Matsui
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Aortic Diseases ,Aorta, Thoracic ,Blood Vessel Prosthesis Implantation ,Esophageal Fistula ,Blood vessel prosthesis ,medicine.artery ,medicine ,Humans ,Transplantation, Homologous ,Thoracic aorta ,Esophagus ,Aged ,Aged, 80 and over ,Vascular Fistula ,business.industry ,Endovascular Procedures ,General Medicine ,Middle Aged ,Greater omentum ,Blood Vessel Prosthesis ,Surgery ,Cardiac surgery ,Esophagectomy ,Transplantation ,Cross-Sectional Studies ,medicine.anatomical_structure ,Cardiothoracic surgery ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
The development fistulas between the thoracic aorta and the esophagus are highly fatal conditions. We aimed to identify a therapeutic strategy for treating aortoesophageal fistula (AEF) in this study, by investigating all AEF cases presented in this special symposium at the 65th Annual Scientific Meeting of the Japanese Association for Thoracic Surgery. Forty-seven AEF patients were included in this study. The survivors and nonsurvivors at six and 18 months after diagnosis of AEF were classified into “Group A6”, “Group D6”, “Group A18”, and “Group D18”, respectively. Comparisons between Group A6 and Group D6 and between Group A18 and Group D18 were made with regard to therapeutic strategy. Twenty-two (46.8 %) and 33 (70.3 %) of the 47 patients died within 6 and 18 months, respectively. The patients treated with omentum wrapping (p = 0.0052), esophagectomy (p = 0.0269) and a graft replacement strategy for the aorta (p = 0.002) were more frequently included in Group A6. The patients with the omentum wrapping (p = 0.0174) and esophagectomy (p = 0.0203) and graft replacement were more significantly included in Group A18. The results of the multivariate analysis indicated that the mortality rate at 6 and 18 months after diagnosis was significantly correlated with graft replacement (p = 0.0188) and esophagectomy (p = 0.0257), respectively. There were significant differences in the actuarial survival curves in patients who had omentum wrapping, graft replacement, and esophagectomy compared to patients who did not have these 3 therapeutic procedures. The use of thoracic endovascular aortic repair alone for AEF should not be considered a definitive surgery. In contrast, esophagectomy, open surgery with aortic replacement using prostheses and homografts and greater omentum wrapping significantly improve the mid-term survival of AEF.
- Published
- 2014
78. Benefits of submitral procedures for ischemic mitral regurgitation
- Author
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Yoshiro Matsui and Satoru Wakasa
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Mitral Valve Annuloplasty ,Heart Ventricles ,Myocardial Ischemia ,Cardiomyopathy ,Ventricular Dysfunction, Left ,Recurrence ,Internal medicine ,Mitral valve annuloplasty ,Mitral valve ,medicine ,Humans ,Cardiac Surgical Procedures ,Ventricular remodeling ,Papillary muscle ,Ventricular Remodeling ,business.industry ,Mitral Valve Insufficiency ,General Medicine ,Papillary Muscles ,medicine.disease ,Cardiac surgery ,medicine.anatomical_structure ,Ventricle ,Cardiothoracic surgery ,Cardiology ,Surgery ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
The surgical strategy for ischemic mitral regurgitation (MR) remains controversial. Ischemic MR is a secondary valve disease caused by left ventricular (LV) remodeling and subsequent papillary muscle displacement, usually without structural valve lesions. Reduction annuloplasty is the standard surgical procedure for this condition, though it cannot clearly provide a survival benefit for those with LV dysfunction and is associated with a high prevalence of late recurrence of MR. The valvular procedure alone could be insufficient to treat ischemic MR in terms of long-term survival and the prevention of recurrence because ischemic MR is primarily a ventricular disorder. Thus, recent studies have focused on alternative procedures that target the primary cause of ischemic MR, the papillary muscles and left ventricle. We believe that the appropriate selection of surgical procedures among valvular, subvalvular, and even ventricular ones, considering the severity of LV remodeling for each patient would be more beneficial. Here we review recent studies featuring various surgical approaches to ischemic MR, especially with submitral procedures.
- Published
- 2014
79. Histological assessment of transmurality after repeated radiofrequency ablation of the left atrial wall
- Author
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Tomonori Ooka, Hiroki Kato, Suguru Kubota, Satoru Wakasa, Tsuyoshi Tachibana, Yasushige Shingu, and Yoshiro Matsui
- Subjects
Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Radiofrequency ablation ,law.invention ,Left atrial wall ,Surgical oncology ,law ,Atrial Fibrillation ,Humans ,Medicine ,Atrial Appendage ,Heart Atria ,Aged ,business.industry ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Cardiac surgery ,surgical procedures, operative ,Cardiothoracic surgery ,Catheter Ablation ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,therapeutics ,Surgical ablation - Abstract
Radiofrequency ablation (RFA) makes the Cox-Maze procedure less complicated but cannot always achieve transmural lesions. In this study, we assessed whether repeated application of RFA could improve histological transmurality even in thick lesions.Left atrial appendages (LAA) amputated from 20 consecutive patients (age 68 ± 9 years, 9 males) who underwent the Cox-Maze procedure using bipolar RFA devices were studied. Three different segments in the amputated LAA were ablated once, twice, or three times. Thereafter, cross sections made along each of the ablation lines were histologically assessed. Transmurality, which was defined as completion of transmural fibrotic changes, and wall thickness were investigated at an average of 3 different sites in each section.A total of 177 sites were investigated and divided into groups with single, double, and triple RFA treatments for 56, 61, and 60 lesions, respectively. Transmural lesions were observed in 25 (45 %), 27 (44 %), and 41 (68 %) lesions, respectively (P = 0.011). The transmurality was 100 % for all lesions with a thickness of 1.0 mm or less. In the thicker lesions (1.0 mm), however, wall thickness impaired transmurality, though triple RFA was associated with significantly higher transmurality than single and double RFA (P = 0.005).Triple repetition of RFA was associated with higher transmurality of lesions than double RFA, especially for thicker lesions. Increasing the number of repetitions could improve the success rate of the Cox-Maze procedure using RFA devices.
- Published
- 2014
80. Mitral valve surgery for ischemic mitral regurgitation with left ventricular dysfunction
- Author
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Yoshiro Matsui and Satoru Wakasa
- Subjects
medicine.medical_specialty ,Ischemic mitral regurgitation ,business.industry ,Internal medicine ,Cardiology ,medicine ,business ,Mitral valve surgery - Published
- 2014
81. Predictors of High Defibrillation Threshold in Patients With Implantable Cardioverter-Defibillator Using a Transvenous Dual-Coil Lead
- Author
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Kazuya Mizukami, Hiroyuki Tsutsui, Hirofumi Mitsuyama, Hisashi Yokoshiki, Taro Tenma, Yoshiro Matsui, and Masaya Watanabe
- Subjects
Male ,medicine.medical_specialty ,Heart Diseases ,Defibrillation ,medicine.medical_treatment ,Defibrillation threshold ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,Heart Septum ,Humans ,Medicine ,Interventricular septum ,Electrodes ,Retrospective Studies ,business.industry ,Cardiovascular Agents ,Retrospective cohort study ,Atrial fibrillation ,Equipment Design ,Hypertrophy ,General Medicine ,Odds ratio ,Middle Aged ,Implantable cardioverter-defibrillator ,medicine.disease ,Combined Modality Therapy ,Confidence interval ,Defibrillators, Implantable ,medicine.anatomical_structure ,Hypertension ,Ventricular Fibrillation ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background:Defibrillation testing (DT) is considered a standard procedure during implantable cardioverter-defibrillator (ICD) implantation. However, little is known about the factors that are significantly related to patients with high defibrillation threshold (DFT) using the present triad system.Methods and Results:We examined 286 consecutive patients who underwent ICD implantation with a transvenous dual-coil lead and DT from December 2000 to December 2011. We defined patients who required 25 J or more by the implanted device as the high DFT group, and those who required less than 25 J as the normal DFT group. For each patient, assessment parameters included underlying disease, comorbidities, NYHA functional class, drugs, and echocardiographic measures. The high DFT group consisted of 12 patients (4.2%). Multivariate analysis identified 3 independent predictors for high DFT: atrial fibrillation (odds ratio (OR) 4.85, 95% confidence interval (CI) 1.24–22.33, P=0.023), hypertension (OR 4.01, 95% CI 1.08–15.96, P=0.039), thickness of interventricular septum (IVS) >12 mm (OR 4.82, 95% CI 1.17–20.31, P=0.030).Conclusions:Atrial fibrillation, hypertension and IVS hypertrophy were significantly associated with high DFT. Identification of such patients could help to lower the risk of complications with DT. (Circ J 2015; 79: 77–84)
- Published
- 2014
82. Surgical treatment for ischemic mitral regurgitation adopting submitral and ventricular procedures according to severity of left ventricular remodeling
- Author
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Yoshiro Matsui and Satoru Wakasa
- Subjects
medicine.medical_specialty ,Ischemic mitral regurgitation ,business.industry ,Internal medicine ,medicine ,Cardiology ,Surgical treatment ,Ventricular remodeling ,medicine.disease ,business - Published
- 2014
83. Early Results Of A New Method Of Mitral Valve Replacement Combined With Submitral Procedures For Non-ischemic Dilated Cardiomyopathy
- Author
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Yasushige Shingu, Yoshiro Matsui, and Takahiro Ishigaki
- Subjects
endocrine system ,Mitral valve repair ,medicine.medical_specialty ,Mitral regurgitation ,business.industry ,medicine.medical_treatment ,Mitral valve replacement ,Dilated cardiomyopathy ,medicine.disease ,Early results ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,cardiovascular diseases ,Non ischemic ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objective: We performed mitral valve repair (MVr) with left ventriculoplasty (MVr+LVP group) for non-ischemic dilated cardiomyopathy (NIDCM) with severe mitral regurgitation (MR) before 2015. We ha...
- Published
- 2019
84. Can Mitral Valve Replacement Be The First-line Intervention? - LVAD Implantation Alone Vs. Chordal Sparing Mitral Valve Replacement With Submitral Procedures For End-stage Heart Failure
- Author
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Takahiro Ishigaki, Tomonori Ooka, Yasushige Shingu, Yoshiro Matsui, and Suguru Kubota
- Subjects
medicine.medical_specialty ,business.industry ,Intervention (counseling) ,Internal medicine ,First line ,medicine.medical_treatment ,Mitral valve replacement ,Cardiology ,Medicine ,End stage heart failure ,Cardiology and Cardiovascular Medicine ,business - Published
- 2019
85. Estimating postoperative left ventricular volume: Identification of responders to surgical ventricular reconstruction
- Author
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Tadashi Isomura, Yoshiki Sawa, Hitoshi Yaku, Ryuzo Sakata, Goro Matsumiya, Shuichiro Takanashi, Tatsuhiko Komiya, Hirokuni Arai, Yoshiro Matsui, Atsushi Yamaguchi, Junjiro Kobayashi, Kimikazu Hamano, Satoru Wakasa, Hideyuki Shimizu, Yasunori Cho, Yoshikatsu Saiki, and Akihiko Usui
- Subjects
Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Time Factors ,Heart Ventricles ,coronary artery bypass grafting ,responder ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,Ventricular Dysfunction, Left ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Interquartile range ,Internal medicine ,Mitral valve ,medicine ,Humans ,030212 general & internal medicine ,Coronary Artery Bypass ,Aged ,Retrospective Studies ,Ischemic cardiomyopathy ,Ejection fraction ,Ventricular Remodeling ,medicine.diagnostic_test ,ischemic cardiomyopathy ,business.industry ,Stroke Volume ,Magnetic resonance imaging ,Recovery of Function ,Middle Aged ,Plastic Surgery Procedures ,Treatment Outcome ,medicine.anatomical_structure ,surgical ventricular reconstruction ,Cardiology ,Ventricular volume ,Female ,Surgery ,Cardiology and Cardiovascular Medicine ,Ischemic heart ,business ,Artery - Abstract
Objectives: The postoperative left ventricular end-systolic volume index and ejection fraction are benchmarks of surgical ventricular reconstruction but remain unpredictable. This study aimed to identify who could be associated with a higher long-term survival by adding surgical ventricular reconstruction to coronary artery bypass grafting than coronary artery bypass grafting alone (responders to surgical ventricular reconstruction). Methods: The subjects were 293 patients (median age, 63 years; 255 men) who underwent coronary artery bypass grafting for ischemic heart disease with left ventricular dysfunction in 16 cardiovascular centers in Japan. The relationships among surgical ventricular reconstruction, postoperative end-systolic volume index, ejection fraction, and survival were analyzed to identify responders to surgical ventricular reconstruction. Results: Surgical ventricular reconstruction was performed in 165 patients (56%). The end-systolic volume index and ejection fraction significantly improved (end-systolic volume index, 91 to 64 mL/m2; ejection fraction, 28% to 35%) for all patients. The postoperative end-systolic volume index and ejection fraction were estimated, and surgical ventricular reconstruction was found to be significantly associated with both end-systolic volume index (14.5 mL/m2 reduction, P < .001) and ejection fraction (3.1% increase, P = .003). During the median follow-up of 6.8 years, 69 patients (24%) died. Only the postoperative ejection fraction was significantly associated with survival (hazard ratio, 0.925; 95% confidence interval, 0.885-0.968), although this effect was limited to those with postoperative end-systolic volume index of 40 to 80 mL/m2 in the subgroup analysis (hazard ratio, 0.932; 95% confidence interval, 0.894-0.973). Conclusions: Adding surgical ventricular reconstruction to coronary artery bypass grafting could reduce the mortality risk by increasing ejection fraction for those with a postoperative end-systolic volume index within a specific range. The postoperative end-systolic volume index could demarcate responders to surgical ventricular reconstruction, and its estimation can help in surgical decision making.
- Published
- 2018
86. Surgical strategy for aortoesophageal fistula in the endovascular era
- Author
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Yasushige Shingu, Norihiko Shiiya, Suguru Kubota, Yoshimitu Ishibashi, Satoru Wakasa, Hidetoshi Yamauchi, Yoshiro Matsui, Tsuyoshi Tachibana, Tomonori Ooka, and Junichi Oba
- Subjects
Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Surgical strategy ,medicine.medical_treatment ,Aortic Diseases ,MEDLINE ,Esophageal Fistula ,Esophagus ,Aortoesophageal fistula ,Surgical oncology ,medicine ,Humans ,cardiovascular diseases ,Aorta ,Aged ,Retrospective Studies ,Vascular Fistula ,business.industry ,General surgery ,Endovascular Procedures ,Retrospective cohort study ,General Medicine ,Middle Aged ,Thoracic Surgical Procedures ,Cardiac surgery ,Surgery ,Esophagectomy ,Cardiothoracic surgery ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aortoesophageal fistula (AEF) is relatively rare and usually life-threatening. Lots of strategies have so far been discussed for this entity including the role of endovascular repair. The aim of this study is to review our experiences and reconsider the surgical strategy for aortoesophageal fistula in the endovascular era.This is a retrospective multicenter study. From 1995 to 2011, 10 aortoesophageal fistula cases were identified in four institutions. For all of these cases surgical procedures and results were retrieved from medical records.Six patients underwent open aortic repair and four patients underwent thoracic endovascular aortic repair (TEVAR) as a primary intervention. Three patients who underwent open aortic repair with esophagectomy and omental coverage in early phase, either as a primary intervention or performed after bridging TEVAR, showed 100 % 1-year survival. On the other hand, three patients with TEVAR alone did not survive more than 1 year without recurrence. One patient with bridging TEVAR underwent concomitant esophageal resection and conventional aortic graft replacement 2 days later, and simultaneous gastric tube reconstruction was performed with intact whole omentum covering the aortic prosthesis. This patient is doing well with no sign of infection at 1-year follow-up.For AEF, TEVAR as a primary approach is quite useful to stabilize the patients' condition. However, definitive aortic repair with omental coverage should be performed as early as possible as a next step. It may be one of the strategies for the treatment of AEF that concomitant esophageal resection and aortic graft replacement is performed with simultaneous gastric tube reconstruction with intact whole omentum after removing the stent graft, so far as the patient's physical condition permits.
- Published
- 2013
87. Intraoperative lacrimal intubation to prevent epiphora as a result of injury to the nasolacrimal system after fracture of the naso-orbitoethmoid complex
- Author
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Susumu Omura, Yoshiro Matsui, Yuichiro Yabuki, Makiko Okubo, Iwai Tohnai, Kazunori Yasumura, Ryo Fujimaki, Shinji Kobayashi, Jiro Maegawa, and Toshinori Iwai
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Lacrimal duct ,medicine.medical_treatment ,Computed tomography ,medicine ,Humans ,Intubation ,Internal fixation ,Nasal Bone ,General anaesthesia ,Intraoperative Complications ,Orbital Fractures ,Silicone tube ,Reduction (orthopedic surgery) ,Lacrimal Apparatus Diseases ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Surgery ,Ethmoid Bone ,Treatment Outcome ,Otorhinolaryngology ,Anesthesia ,Female ,Oral Surgery ,Tomography, X-Ray Computed ,Complication ,business ,Nasolacrimal Duct ,Follow-Up Studies - Abstract
Treatment of fracture of the naso-orbitoethmoid (NOE) complex is difficult. There are not only aesthetic issues but also functional consequences related to the lacrimal system. Because prophylactic lacrimal intubation for such fractures remains controversial, we have assessed the effectiveness of intraoperative lacrimal intubation to prevent epiphora as a result of such injuries. Thirteen patients diagnosed with craniomaxillofacial fractures including fractures of the NOE complex were included in the study; 10 had unilateral fractures and 3 bilateral. Computed tomography (CT) showed all patients had displaced fragments that had the potential to damage the lacrimal duct. In 7 patients the fractures included the canthal region and in 6 they did not. All patients were treated by open reduction and internal fixation under general anaesthesia, followed by intraoperative lacrimal intubation unilaterally or bilaterally as required. Lacrimal intubation with a silicone tube was successful in all 13 patients (16 sides). The tube was removed 2-9 months (mean 3.8) postoperatively and no subsequent epiphora were seen during follow-up (mean (3-29 months) 11.3 months). Lacrimal intubation for at least 2 months may prevent epiphora caused by injury to the nasolacrimal system after fractures of the NOE complex.
- Published
- 2013
88. One-stage radical operation of aortoesophageal fistula -combination of VATS esophagectomy and open aortic surgery: report of a case
- Author
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Satoru Wakasa, Kentaro Kato, Yo Kurashima, Yuma Ebihara, Takahiro Tsuchikawa, Eiichi Tanaka, Satoshi Hirano, Toshiaki Shichinohe, Suguru Kubota, and Yoshiro Matsui
- Subjects
Aortic graft ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Gastric conduit ,Gastroenterology ,Aortoesophageal fistula ,One stage ,One-stage operation ,Surgery ,VATS esophagectomy ,surgical procedures, operative ,Esophagectomy ,Cardiothoracic surgery ,Open aortic surgery ,cardiovascular system ,medicine ,Fatal disease ,business - Abstract
Aortoesophageal fistula is a rare but fatal disease of thoracic surgery. We present a case of a 74-year-old male with aortoesophageal fistula. The patient underwent successful one-stage surgical treatment by video-assisted esophagectomy with esophageal reconstruction by gastric conduit and open aortic graft replacement subsequent to a temporary thoracic endovascular aortic repair.
- Published
- 2013
89. Mandibular Ewing Sarcoma With Chromosomal Translocation t(21;22)(q22;q12)
- Author
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Maiko Shibasaki, Toshinori Iwai, Yoshiaki Inayama, Yoshiro Matsui, Jiro Maegawa, Iwai Tohnai, Shinsuke Ohta, Kenji Mitsudo, Shumpei Yokota, and Tomoko Yokosuka
- Subjects
Male ,Oncogene Proteins, Fusion ,Chromosomes, Human, Pair 21 ,Chromosomes, Human, Pair 22 ,Population ,Chromosomal translocation ,Sarcoma, Ewing ,Translocation, Genetic ,medicine ,Humans ,Child ,education ,education.field_of_study ,business.industry ,Chromosome ,General Medicine ,medicine.disease ,Combined Modality Therapy ,Mandibular Neoplasms ,Primary bone ,Otorhinolaryngology ,Cancer research ,Osteosarcoma ,Surgery ,Sarcoma ,Chromosome 21 ,business ,Chromosome 22 ,Transcription Factors - Abstract
Ewing sarcoma (ES) is a primary bone malignant neoplasm and is the second most common primary malignancy of the bone found in childhood and adolescence after osteosarcoma. ES has an annual frequency in the population younger than 20 years of approximately 2.9 per million. ES occurs most frequently in the long bones of the extremities and pelvis and very rarely in the jaw. Recently, it was revealed that chromosomal translocation t(11;22)(q24;q12), which fuses the EWS gene on chromosome 22 and the FLI-1 gene on chromosome 11, occurs in most cases of ES. We report here a rare case of mandibular ES in a 10-year-old child with chromosomal translocation t(21;22)(q22;q12) in which the EWS gene is fused with the ERG gene on chromosome 21.
- Published
- 2013
90. Thrombosis in the Pulmonary Vein Stump After Left Upper Lobectomy as a Possible Cause of Cerebral Infarction
- Author
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Reiko Nakada-Kubota, Tsukasa Sasaki, Yoshiro Matsui, Kichizo Kaga, Yasuhiro Hida, Jun Muto, Kazuto Ohtaka, and Tatsuya Kato
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Operative Time ,Contrast Media ,Anastomosis ,Risk Assessment ,Statistics, Nonparametric ,Pulmonary vein ,Cohort Studies ,Postoperative Complications ,medicine ,Humans ,Thrombus ,Pneumonectomy ,Survival rate ,Aged ,Retrospective Studies ,Aged, 80 and over ,Venous Thrombosis ,Analysis of Variance ,Cerebral infarction ,business.industry ,Anastomosis, Surgical ,Cerebral Infarction ,Middle Aged ,medicine.disease ,Thrombosis ,Surgery ,Survival Rate ,body regions ,Treatment Outcome ,Embolism ,Chemotherapy, Adjuvant ,Pulmonary Veins ,Multivariate Analysis ,Female ,Radiology ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,Complication ,business ,Follow-Up Studies - Abstract
Background. Thrombus in the stump of the pulmonary vein (PV) is not a well-known complication after lung resection, and it has the potential to cause embolism to vital organs. To clarify the frequency, risk factors, and cause of this complication, a retrospective clinical study of patients who underwent lobectomy was performed. Methods. The study evaluated 193 patients with primary lung cancer who underwent lobectomy from 2005 to 2011 and contrast-enhanced chest computed tomography (CT) within 2 years after lobectomy. Contrast-enhanced CT was retrospectively interpreted to check for thrombus in the PV stump. Results. The operative procedures were 65 right upper lobectomies, 14 right middle lobectomies, 40 right lower lobectomies, 52 left upper lobectomies (LUL), and 22 left lower lobectomies. Thrombus developed in the PV stump in 7 of the 193 patients (3.6%) after lobectomy. All patients with thrombus had undergone LUL, and 13.5% of those who had undergone LUL developed thrombus. Univariate analyses revealed that LUL and operation time were significant risk factors and that adjuvant chemotherapy was marginally significant. It appears that thrombus may be attributable to the length of the PV stump. Measurement of the length of the PV stump using 3-dimensional CT images of the PV revealed that the stump of the left superior PV was longer than the others. Conclusions. Thrombus in the PV stump occurred in 13.5% of patients after LUL. These findings suggest that contrast-enhanced CT should be recommended for patients after LUL to help identify those with a high risk for thromboembolism. (C) 2013 by The Society of Thoracic Surgeons
- Published
- 2013
91. Cervicofacial subcutaneous and mediastinal emphysema caused by air cooling spray of dental laser
- Author
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Jiro Maegawa, Sachiyo Mitsunaga, Iwai Tohnai, Makoto Hirota, Toshinori Iwai, Kenji Mitsudo, Noriaki Aoki, Yoshiro Matsui, Yosuke Yamashita, and Susumu Omura
- Subjects
medicine.medical_specialty ,Oral Surgeon ,Radiography ,Computed tomography ,Pathology and Forensic Medicine ,stomatognathic system ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Dental Care ,Mediastinal Emphysema ,Aged ,medicine.diagnostic_test ,business.industry ,Dental procedures ,respiratory system ,Subcutaneous Emphysema ,respiratory tract diseases ,Surgery ,stomatognathic diseases ,Tooth Extraction ,Female ,Laser Therapy ,Oral Surgery ,medicine.symptom ,business ,Complication ,Subcutaneous emphysema ,Dental laser - Abstract
Cervicofacial subcutaneous emphysema is a rare complication of dental procedures with an air turbine or syringe, and dentists and oral surgeons sometimes encounter mediastinal emphysema following the presentation of extensive subcutaneous emphysema. Most emphysema occurs incidentally during tooth extraction, restorative treatment, or endodontic treatment, with only a few cases reported of cervicofacial subcutaneous emphysema associated with dental laser treatment. We report a case of cervicofacial subcutaneous and mediastinal emphysema caused by the air cooling spray of dental laser during dental treatment in a 76-year-old woman. After she underwent dental laser treatment, cervicofacial swelling was noted and she was referred to our department. Computed tomography showed both cervicofacial subcutaneous emphysema and mediastinal emphysema. Antibiotics were administered prophylactically and the emphysema disappeared 5 days after the dental laser treatment, without any complications.
- Published
- 2013
92. Reduced port video-assisted thoracoscopic surgery using a needle scope for lung and mediastinal lesions
- Author
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Kichizo Kaga, Tatsuya Kato, Yoshiro Matsui, Jun Muto, Yasuhiro Hida, Keidai Ishikawa, Reiko Nakada-Kubota, and Kazuto Ohtaka
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Time Factors ,Adolescent ,medicine.medical_treatment ,Adhesion (medicine) ,Punctures ,Mediastinal Neoplasms ,Puncture procedure ,Young Adult ,Japan ,Risk Factors ,medicine ,Humans ,Thoracotomy ,Child ,Aged ,Retrospective Studies ,Aged, 80 and over ,Chi-Square Distribution ,Thoracic Surgery, Video-Assisted ,business.industry ,Patient Selection ,Infant, Newborn ,Infant ,Mediastinum ,Equipment Design ,Original Articles ,Middle Aged ,Thoracoscopes ,medicine.disease ,Mediastinal Neoplasm ,Surgery ,Dissection ,Treatment Outcome ,medicine.anatomical_structure ,Child, Preschool ,Video-assisted thoracoscopic surgery ,Feasibility Studies ,Female ,Cardiology and Cardiovascular Medicine ,business ,Mediastinal Diseases - Abstract
OBJECTIVES: There are many recent and minimally invasive surgical innovations, yet there has been little evaluation of the limitations of such techniques, particularly those related to video-assisted thoracoscopic surgery. The aims of this study were to determine the usefulness and limitations of video-assisted thoracoscopic surgery using one-port access and needle scope and to evaluate the feasibility of this procedure based on our institutional experience. METHODS: This retrospective study involved 127 patients who underwent video-assisted thoracoscopic surgery using the one-window and puncture method at our institute from 1997 to 2011. One hundred patients underwent surgical treatment and 27 underwent diagnostic procedures. If there was one lesion present with only mild adhesion that did not require lymph node dissection, we decided to opt for the one-direction approach that provisionally indicates the one-window and puncture method. We compared the conversion and success groups for factors like age, sex, laterality of surgery, objective of surgery, target organ and surgery location. RESULTS: Of 127 cases, 115 (91%) successfully underwent the one-window and puncture procedure. Twelve cases (9%) were converted to the two-window method or thoracotomy. Compared with those targeting the lung, patients with mediastinal lesions demonstrated a higher tendency for conversion (P< 0.05). However, age (P= 0.89), sex (P= 0.46), laterality of surgery (P= 0.34) and purpose of surgery (P= 0.68) did not show any significant differences between the groups. CONCLUSIONS: For lung and mediastinal diseases, video-assisted thoracoscopic surgery with the one-window and puncture method can be performed at any location (upper, middle and lower lobe of lung and anterior, middle and posterior of the mediastinum) under limited indications that include the possibility of one-way resection, mild adhesion and no requirement of lymph node dissection. Under provisional criteria, the procedure may be feasible.
- Published
- 2013
93. Metastasis in the Gingiva from Colon Adenocarcinoma
- Author
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Yoshiro Matsui, Yumiko Ohbayashi, Yoshio Kushida, Ryusuke Takebayashi, and Minoru Miyake
- Subjects
Chemotherapy ,Pathology ,medicine.medical_specialty ,business.industry ,Pyogenic granuloma ,Epulis ,medicine.medical_treatment ,Case Report ,medicine.disease ,digestive system diseases ,Metastasis ,medicine.anatomical_structure ,Otorhinolaryngology ,Oral and maxillofacial surgery ,medicine ,Premolar ,Surgery ,Oral Surgery ,Differential diagnosis ,business ,Colectomy - Abstract
A case of gingival metastatic tumor from a colon adenocarcinoma is reported. The patient had been diagnosed with colon carcinoma and underwent a colectomy with D2 dissection, followed by chemotherapy. Nine months after the initial treatment, she noticed a periodontal gingival swelling at the site of her right lower second premolar and was referred to our clinic. The clinical diagnosis was an epulis granulomatosa or pyogenic granuloma. A metastatic adenocarcinoma in the gingiva from colon carcinoma was identified after the histopathological examination. Although rare, oral metastatic tumors should be included in the differential diagnosis, particularly if the patient has a prior history of malignancies.
- Published
- 2013
94. Method for the validation of immunohistochemical staining using SCID mouse xenografts: Expression of CD40 and CD154 in human non-small cell lung cancer
- Author
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Roshan Mishra, Yoshiro Matsui, Tatsuya Kato, Li Li, Kichizo Kaga, Toshiro Ohbuchi, Keidai Ishikawa, Masatoshi Kadoya, Tatsuya Yoshioka, Masaki Miyamoto, Hirotoshi Dosaka-Akita, Yasuhito Shoji, Yasuhiro Hida, Tomoo Itoh, Satoshi Hirano, Kazuomi Ichinokawa, Mitsuhito Kaji, and Yoshiyuki Matsumura
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Lung Neoplasms ,CD40 Ligand ,Mice, SCID ,Mice ,positive control ,Western blot ,Carcinoma, Non-Small-Cell Lung ,CD40 ,medicine ,Animals ,Humans ,CD154 ,xenograft ,CD40 Antigens ,Staining and Labeling ,biology ,medicine.diagnostic_test ,Cancer ,Articles ,General Medicine ,Cell cycle ,medicine.disease ,Immunohistochemistry ,Xenograft Model Antitumor Assays ,Primary and secondary antibodies ,Antibodies, Anti-Idiotypic ,Staining ,Gene Expression Regulation, Neoplastic ,lung cancer ,Oncology ,biology.protein ,Antibody ,Immunostaining - Abstract
This report proposes a concept for the standardization of immunohistochemical evaluation. Immunohistochemical staining has several problems associated with the sensitivity of the technical process and standardization of the assessment of potent staining. We provided data focusing on this concept through immunostaining for CD154 in non-small cell lung cancer (NSCLC). We used two types of anti-CD154 antibody as primary antibodies in immunohistochemical staining, as previously reported. Western blot analysis confirmed strong CD154 expression in the cultured cell line PC10, but not in LK2. We also assessed CD154 expression in SCID mouse xenografts of these cell lines. SCID xenograft data on western blot analysis were consistent with those of cultured cell lines. These xenografts could thus be used as positive or negative tissue controls for CD154 immunostaining. Primary antibodies should therefore be confirmed as recognizing target lesions, while control tissue specimens should be objectively confirmed as having target products using another experimental method. Our method would allow results to be unified at more than one laboratory and could act as an objective control assessment method in immunohistochemistry.
- Published
- 2013
95. Objective evaluation of postoperative function in patients who underwent reconstruction after ablation of cancer of the tongue and/or floor of the mouth
- Author
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Masao Matsuura, Masaya Ohkura, Kanichi Seto, Mitsunobu Ono, Sadao Okabe, Yukihiko Kinoshita, Kanchu Tei, Kazunari Oobu, Kiyohide Fujita, Yoshiro Matsui, Tomomi Yamamoto, Satoru Ozeki, Satoshi Umino, Masaru Hosoda, Yasunori Totsuka, Hiroshige Chiba, Kenichi Tomitsuka, Kouichi Asada, Teruo Amagasa, Toru Sato, Hidemi Yoshimasu, Seiji Iida, K. Ohno, Tatsuo Shirota, Katsunori Ishibashi, Yukari Yamashita, Koji Fujibayashi, Takahumi Satomi, and Mikihiko Kogo
- Subjects
medicine.medical_specialty ,Floor of mouth ,business.industry ,medicine.medical_treatment ,Cancer ,Ablation ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Tongue ,medicine ,In patient ,Objective evaluation ,business - Published
- 2013
96. Anticoagulation Management in the Perioperative Phase of Implantable Cardioverter Defibrillator Implantation
- Author
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Masaya Watanabe, Kazuya Mizukami, Hisashi Yokoshiki, Yoshiro Matsui, Hiroyuki Tsutsui, and Hirofumi Mitsuyama
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Hemorrhage ,Pericardial effusion ,Perioperative Care ,Postoperative Complications ,Hematoma ,Cardiac tamponade ,medicine ,Humans ,International Normalized Ratio ,Aged ,Retrospective Studies ,Heparin ,business.industry ,Warfarin ,Anticoagulants ,General Medicine ,Perioperative ,Odds ratio ,Middle Aged ,medicine.disease ,Implantable cardioverter-defibrillator ,Defibrillators, Implantable ,Surgery ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Background: According to the current guidelines, substitution of warfarin with heparin is recommended as perioperative management in patients with high risk of thromboembolism. Optimal management of oral anticoagulation in patients undergoing implantable cardioverter defibrillator (ICD) implantation, however, remains controversial. Methods and Results: Bleeding complications among 273 consecutive patients undergoing initial ICD implantation were retrospectively analyzed. Patients were grouped according to medication at the time of device implantation: neither antiplatelet nor anticoagulation (N group, n=121); antiplatelet only (AP group, n=59); warfarin (W group, n=59); and heparin bridging (H group, n=34). The rate of the major bleeding complications, defined as hematoma requiring reoperation, cardiac tamponade, and pericardial effusion requiring additional hospital stay, was 1.7% in the N group, 0% in the AP group, 5.1% in the W group, and 17.6% in the H group (P
- Published
- 2013
97. Diagnostic Value of Cytology of Pericardial Effusion for Cardiac Malignant Lymphoma
- Author
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Yuji Naito, Yoshiro Matsui, Satoru Wakasa, Yasushige Shingu, Suguru Kubota, Tsuyoshi Tachibana, Hidetsugu Asai, and Tomonori Ōoka
- Subjects
Malignant lymphoma ,medicine.medical_specialty ,business.industry ,Cytology ,medicine ,Radiology ,business ,medicine.disease ,Value (mathematics) ,Pericardial effusion - Published
- 2013
98. [Uniquely Shaped Giant Thrombus in the Right Atrium after Long-term Insertion of Central Venous Catheters]
- Author
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Takehiro, Kubota, Kunishige, Okamura, and Yoshiro, Matsui
- Subjects
Male ,Catheterization, Central Venous ,Central Venous Catheters ,Humans ,Thrombosis ,Heart Atria ,Cardiac Surgical Procedures ,Tomography, X-Ray Computed ,Magnetic Resonance Imaging ,Aged - Abstract
Thrombosis around intravenous catheters are often found in daily practice, and their treatment must be considered if they are mobile or large. However, in such giant thrombosis cases as this one, it is considered that thrombolytic therapy is ineffective and that immediate surgical resection is the best choice of treatment. The patient had a very uniquely-shaped right atrial thrombus.
- Published
- 2016
99. [Ventricular assist device and heart transplantation for patients with end-stage heart failure due to ischemic cardiomyopathy]
- Author
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Tomonori, Ooka and Yoshiro, Matsui
- Subjects
Heart Failure ,Myocardial Ischemia ,Heart Transplantation ,Humans ,Cardiomyopathies - Published
- 2016
100. Japanese Multicenter Outcomes With the HeartMate II Left Ventricular Assist Device in Patients With Small Body Surface Area
- Author
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Hiroshi Niinami, Hirokuni Arai, Yoshikatsu Saiki, Takeshi Nakatani, Ryuji Tominaga, Goro Matsumiya, Yoshiki Sawa, Kenji Yamazaki, Yoshiro Matsui, and Minoru Ono
- Subjects
Adult ,Male ,medicine.medical_specialty ,Body Surface Area ,medicine.medical_treatment ,Hemodynamics ,030204 cardiovascular system & hematology ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Japan ,Internal medicine ,medicine ,Humans ,Registries ,Adverse effect ,Survival rate ,Stroke ,Aged ,Body surface area ,business.industry ,Age Factors ,General Medicine ,Perioperative ,Middle Aged ,medicine.disease ,Survival Rate ,030228 respiratory system ,Intracranial Embolism ,Heart failure ,Ventricular assist device ,Cardiology ,Female ,Heart-Assist Devices ,Cardiology and Cardiovascular Medicine ,business ,Intracranial Hemorrhages - Abstract
BACKGROUND The HeartMate II (HMII) continuous-flow LVAD was approved for Japanese health insurance coverage in April 2013 as a bridge to transplantation (BTT). We report on post-approval Japanese multicenter outcomes, and a comparison between patients with low and high body surface area (BSA). METHODS AND RESULTS HMII LVAD was implanted in 104 consecutive patients at 15 Japanese centers between April 2013 and July 2014. Perioperative data were submitted to the Japanese Registry for Mechanically Assisted Circulatory Support. Patients were divided into 2 groups on the basis of BSA less or greater than 1.5 m(2). Survival outcomes, New York Heart Association functional class, and adverse event rates were compared between the 2 groups. Preoperative hemodynamics and INTERMACS profiles were similar between groups. There were more females and younger patients in the low BSA group. The respective 6-month and 1-year death- or pump exchange-free survival rates were excellent: 90% and 90% in the BSA
- Published
- 2016
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