Search

Objective: To observe the effect of emodin on the biological behavior of human fibroblasts (FB) in culture of kidney in patients with lupus nephritis (LN).Methods: FB were isolated from kidney culture of LN patients, and the effect of emodin on3H-TdR incorporated rate of FB was observed. The apoptosis and c-myc gene expression were detected in the same way by flow cytometry.Results: Emodin could markedly inhibit the proliferation of human kidney FB, and inducing cell apoptosis through up-regulating c-myc gene expression in human renal FB.Conclusion: Emodin can inhibit proliferation and promote apoptosis of FB, which may be important in ameliorating interstitial fibrosis, and thus improve prognosis of LN.

We study the geometric phase of a qutrit-qubit mixed-spin system in an external homogeneous magnetic field. Both the spin-spin interaction strength J and the external magnetic field B can affect the geometric phase of the system. In addition, we consider the negativity of the composite system. The relationship between the negativity and the geometric phase is obtained. Finally, we calculate the geometric phase for a thermal mixed state and show how the geometric phase depends on the rescaled coupling parameter and temperature. In the limit T → 0, we can recover the result of the ground state. This analysis has some implications in realistic implementations of geometric quantum computation.