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54. Season of Birth and Cardiovascular Mortality in Atrial Fibrillation: A Population-Based Cohort Study

Author

Ying X. Gue, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Gregory Y. H. Lip, and Laurent Fauchier

Subjects
season of birth, atrial fibrillation, mortality, stroke, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The fetal origins hypothesis have associated early life exposures with the development of adverse health outcomes in adulthood. Season of birth has been shown to be associated with overall and cardiovascular mortality. Methods: We performed a retrospective database study to explore the association between season of birth and mortality in patients with atrial fibrillation. Results: A total of 8962 patients with AF were identified in the database with 1253 deaths recorded. AF patients born in spring and summer had a higher mortality rate when compared to those born in autumn and winter (hazard ratio (HR) 1.13, 95% confidence interval (CI) 1.01–1.26, p = 0.03). This effect was consistent in the male subgroup (HR 1.25, 95% CI 1.03–1.51, p = 0.02 for males born in spring; HR 1.24, 95% CI 1.03–1.51, p = 0.03 for males born in summer when compared to winter as the reference) but not in females (HR 1.02, 95% CI 0.79–1.31, p = 0.88 for females born in spring; HR 1.11, 95% CI 0.87–1.42, p = 0.39 for females born in summer when compared to winter as the reference). Results persisted after adjustment for baseline characteristics and clinical risk profile. A similar pattern was observed with cardiovascular mortality. Conclusion: Birth in spring or summer is associated with a higher risk of cardiovascular mortality in male AF patients, but not in females. This could be related to the underlying differences in rates of major adverse clinical events between genders. Further studies should aim at clarifying the mechanisms behind this association, which may help us understand the higher level of risk in female patients with AF.

Published
2021
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58. The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals

Author

Wang YH, Ying X, Xu HL, Yan HL, Li X, and Tang H

Subjects
C6 glioblastoma stem cells, Apoptosis, Blood-brain-barrier, Curcumin liposomes, Brain glioma-bearing rats, Medicine (General), R5-920
Abstract

Yahua Wang, Xue Ying, Haolun Xu, Helu Yan, Xia Li, Hui Tang Key Laboratory of Xinjiang Phytomedicine Resources and Modernization of TCM, School of Pharmaceutical Sciences, Shihezi University, Shihezi, Xinjiang, People’s Republic of China Abstract: Glioblastoma is a kind of malignant gliomas that is almost impossible to cure due to the poor drug transportation across the blood–brain barrier and the existence of glioma stem cells. We prepared a new kind of targeted liposomes in order to improve the drug delivery system onto the glioma cells and induce the apoptosis of glioma stem cells afterward. In this experiment, curcumin was chosen to kill gliomas, while quinacrine was used to induce apoptosis of the glioma stem cells. Also, p-aminophenyl-α-d-mannopyranoside could facilitate the transport of liposomes across the blood–brain barrier and finally target the brain glioma cells. The cell experiments in vitro indicated that the targeted liposomes could significantly improve the antitumor effects of the drugs, while enhancing the uptake effects, apoptosis effects, and endocytic effects of C6 glioma cells and C6 glioma stem cells. Given the animal experiments in vivo, we discovered that the targeted liposomes could obviously increase the survival period of brain glioma-bearing mice and inhibit the growth of gliomas. In summary, curcumin and quinacrine liposomes modified with p-aminophenyl-α-d-mannopyranoside is a potential preparation to treat brain glioma cells and brain glioma stem cells. Keywords: C6 glioblastoma stem cells, apoptosis, blood–brain barrier, curcumin liposomes, brain glioma-bearing rats

Published
2017

59. Gliflozin ( <scp>SGLT2</scp> inhibitor) induced vulvitis

Author

Stephen J. Mounsey, Ying X. Teo, Jaime E. Calonje, and Fiona Mary Lewis

Subjects
Sodium-Glucose Transporter 2, Diabetes Mellitus, Type 2, Candidiasis, Humans, Hypoglycemic Agents, Female, Dermatology, Vulvitis, Sodium-Glucose Transporter 2 Inhibitors
Abstract

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, or gliflozins, are used as mono or combined therapy in the management of diabetes. Genital infections are the most common reported adverse effect, as a result of induced glycosuria. Cutaneous features of patients experiencing vulval symptoms while on SGLT2 inhibitor therapy have not been clearly described in published literature. We have observed a specific inflammatory vulvitis with psoriasiform features in patients taking SGLT2 inhibitors, related to candidiasis in most cases.Demographic and treatment outcomes of 11 patients with characteristic inflammatory changes after starting SGLT2 inhibitors were extracted from electronic records. Ninety-one percent (n = 10) had candidiasis, treated with fluconazole. Six (54.5%) were able to continue SGLT-2 inhibitors through the addition of topical treatments, but five patients had to discontinue the drug.SGLT2 inhibitors can result in characteristic inflammatory vulvitis. Treatment with topical agents and single-dose antifungals may allow patients to continue their therapy to achieve improved glycemic control. In resistant cases, discontinuation of the drug is necessary. We highlight this effect so that early treatment can be initiated to alleviate symptoms and recognition of underlying cause.

Published
2022
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60. SAR444245, a non‐alpha IL2, rescues chronic antigen and CAR‐driven T‐cell dysfunction

Author

Sheikh, I., primary, Choi, A., additional, Reville, P. K., additional, Henderson, J., additional, Rojas, E., additional, Le, C., additional, Okwuchi, C., additional, Carrio, R., additional, Pate, N., additional, Malley, K., additional, Bangari, D., additional, Gavigan, J., additional, Shi, C., additional, Liu, B., additional, Byers, T., additional, Sassoon, I., additional, Cucchetti, M., additional, Wang, R., additional, Agarwal, M., additional, Abbadessa, G., additional, Meibalan, E., additional, Powers, L., additional, Cao, J., additional, Ying, X., additional, Balko, K., additional, Yu, Q., additional, Jiao, J., additional, Cortez‐Retamozo, V., additional, Sidhu, S., additional, Shaffer, D., additional, Li, X., additional, and Green, M. R., additional

Published
2023
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63. Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis

Author

Li Bassi, G, Gibbons, K, Suen, J, Dalton, H, White, N, Corley, A, Shrapnel, S, Hinton, S, Forsyth, S, Laffey, J, Fan, E, Fanning, J, Panigada, M, Bartlett, R, Brodie, D, Burrell, A, Chiumello, D, Elhazmi, A, Esperatti, M, Grasselli, G, Hodgson, C, Ichiba, S, Luna, C, Marwali, E, Merson, L, Murthy, S, Nichol, A, Ogino, M, Pelosi, P, Torres, A, Ng, P, Fraser, J, Al-Dabbous, T, Alfoudri, H, Shamsah, M, Elapavaluru, S, Berg, A, Horn, C, Mayasi, Y, Schroll, S, Meyer, D, Velazco, J, Ploskanych, L, Fikes, W, Bagewadi, R, Dao, M, White, H, Ehlers, A, Shalabi-McGuire, M, Witt, T, Grazioli, L, Lorini, L, Grandin, E, Nunez, J, Reyes, T, Obriain, D, Hunter, S, Ramanan, M, Affleck, J, Veerendra, H, Rai, S, Russell-Brown, J, Nourse, M, Joseph, M, Mitchell, B, Tenzer, M, Abe, R, Cho, H, Jeong, I, Rahman, N, Kakar, V, Brozzi, N, Mehkri, O, Krishnan, S, Duggal, A, Houltham, S, Graf, J, Diaz, R, Orrego, R, Delgado, C, Gonzalez, J, Sanchez, M, Piagnerelli, M, Sarrazin, J, Zabert, A, Espinosa, L, Delgado, P, Delgado, V, Rincon, D, Yanten, A, Duque, M, Al-Hudaib, A, Callahan, M, Taufik, M, Wardoyo, E, Gunawan, M, Trisnaningrum, N, Irawany, V, Rayhan, M, Pesenti, A, Zanella, A, Leone, M, Coppola, S, Colombo, S, Antonelli, M, Carelli, S, Grieco, D, Asaki, M, Hoshino, K, Salazar, L, Duarte, L, Mcnicholas, B, Cosgrave, D, Mccaffrey, J, Bone, A, Hakeem, Y, Winearls, J, Tallott, M, Thomson, D, Arnold-Day, C, Cupido, J, Miller, M, Seymore, L, van Straaten, D, Hssain, A, Aliudin, J, Alqahtani, A, Mohamed, K, Mohamed, A, Tan, D, Villanueva, J, Zaqout, A, Kurtzman, E, Ademi, A, Dobrita, A, El Aoudi, K, Segura, J, Giwangkancana, G, Ohshimo, S, Hitoshi, S, Osatnik, J, Joosten, A, Yang, M, Motos, A, Arancibia, F, Williams, V, Noel, A, Luque, N, Trung, T, Yacoub, S, Fantini, M, Garcia, R, Alvarez, E, Greti, A, Ceccato, A, Sanchez, A, Vazquez, A, Roche-Campo, F, Franch-Llasat, D, Tuazon, D, Amato, M, Cassimiro, L, Pola, F, Ribeiro, F, Fonseca, G, Desai, M, Osborn, E, Deeb, H, Arcadipane, A, Martucci, G, Panarello, G, Vitiello, C, Bianco, C, Occhipinti, G, Rossetti, M, Cuffaro, R, Cho, S, Shimizu, H, Moriyama, N, Kim, J, Kitamura, N, Gebauer, J, Yokoyama, T, Al-Fares, A, Buabbas, S, Alamad, E, Alawadhi, F, Alawadi, K, Tanaka, H, Hashimoto, S, Yamazaki, M, Oh, T, Epler, M, Forney, C, Kruse, L, Feister, J, Williamson, J, Grobengieser, K, Gnall, E, Golden, S, Caroline, M, Shapiro, T, Karaj, C, Thome, L, Sher, L, Vanderland, M, Welch, M, Mcdermott, S, Brain, M, Mineall, S, Kimura, D, Brazzi, L, Sales, G, Ogston, T, Nagpal, D, Fischer, K, Lorusso, R, Rangappa, R, Appu, A, Carton, E, Sen, A, Palacios, A, Rainey, D, Samoukoviv, G, Campisi, J, Durham, L, Neumann, E, Seefeldt, C, Falcucci, O, Emmrich, A, Guy, J, Johns, C, Potzner, K, Zimmermann, C, Espinal, A, Buchtele, N, Schwameis, M, Stecher, S, Singh, D, Barnikel, M, Arenz, L, Zaaqoq, A, Galloway, L, Merley, C, Csete, M, Quesada, L, Saba, I, Kasugai, D, Hiraiwa, H, Tanaka, T, Purnama, Y, Dewayanti, S, Ardiyan, Juzar, D, Siagian, D, Chen, Y, Ratsep, I, Oigus, G, Erikson, K, Post, A, Enneveer, L, Sillaots, P, Manetta, F, Mihelis, E, Sarmiento, I, Narasimhan, M, Varrone, M, Komats, M, Garcia-Diaz, J, Harmon, C, Satyapriya, S, Bhatt, A, Mokadam, N, Uribe, A, Gonzalez, A, Shi, H, Mckeown, J, Pasek, J, Fiorda, J, Echeverria, M, Moreno, R, Zakhary, B, Cavana, M, Cucino, A, Foti, G, Giani, M, Russotto, V, Castagna, V, Dellamore, A, Navalesi, P, Shum, H, Vuysteke, A, Usman, A, Acker, A, Smood, B, Mergler, B, Sertic, F, Subramanian, M, Sperry, A, Rizer, N, Burhan, E, Rasmin, M, Akmal, E, Sitompul, F, Lolong, N, Naivedh, B, Erickson, S, Barrett, P, Dean, D, Daugherty, J, Loforte, A, Khan, I, Abraar Quraishi, M, Desantis, O, So, D, Kandamby, D, Mandei, J, Natanael, H, Yudhalantang, E, Lantang, A, Wijaya, S, Jung, A, Ng, G, Ng, W, Fang, S, Tabah, A, Ratcliffe, M, Duroux, M, Adachi, S, Nakao, S, Blanco, P, Prieto, A, Sanchez, J, Nicholson, M, Butt, W, Serratore, A, Delzoppo, C, Janin, P, Yarad, E, Totaro, R, Coles, J, Pujo, B, Balk, R, Vissing, A, Kapania, E, Hays, J, Fox, S, Yantosh, G, Mishin, P, Yuliarto, S, Hari Santoso, K, Djajalaksana, S, Fatoni, A, Fukuda, M, Liu, K, Battaglini, D, Jimenez, J, Bastos, D, Gaiao, S, Rusmawatiningtyas, D, Buchner, J, Cho, Y, Lee, S, Kawasaki, T, Munshi, L, Sakiyalak, P, Nitayavardhana, P, Seitz, T, Arora, R, Kent, D, Marino, D, Parwar, S, Cheng, A, Miller, J, Fujitani, S, Shimizu, N, Madhok, J, Owyang, C, Buscher, H, Reynolds, C, Maasikas, O, Beljantsev, A, Mihnovits, V, Akimoto, T, Aizawa, M, Horibe, K, Onodera, R, Young, M, George, T, Shekar, K, Mcguinness, N, Irvine, L, Flynn, B, Endo, T, Sugiyama, K, Shimizu, K, Exconde, K, Lussier, L, Lotz, G, Malfertheiner, M, Maier, L, Dreier, E, Kusumastuti, N, Mccloskey, C, Dabaliz, A, Elshazly, T, Smith, J, Szuldrzynski, K, Bielanski, P, Wille, K, Parhar, K, Fiest, K, Codan, C, Shahid, A, Fayed, M, Evans, T, Gutierrez, A, Song, T, Rose, R, Bennett, S, Richardson, D, Peek, G, Arora, L, Rappapport, K, Rudolph, K, Sibenaller, Z, Stout, L, Walter, A, Herr, D, Vedadi, N, Thompson, S, Sindt, L, Rajnic, S, Ewald, C, Hoffman, J, Ying, X, Kennedy, R, Griffee, M, Ciullo, A, Kida, Y, Roca, R, Riera, J, Contreras, S, Alegre, C, Kay, C, Fischer, I, Renner, E, Taniguci, H, Bassi, G, Barnett, A, Pearse, I, Abbate, G, Hassan, H, Heinsar, S, Karnik, V, Ki, K, Oneill, H, Obonyo, N, Pimenta, L, Reid, J, Sato, K, Vuorinen, A, Wildi, K, Wood, E, Yerkovich, S, Lee, J, Plotkin, D, Citarella, B, Hartley, E, Lubis, B, Ikeyama, T, Bhaskar, B, Jung, J, Mcguinness, S, Eastwood, G, Marta, S, Guarracino, F, Gerle, S, Coxon, E, Claro, B, Loverde, D, Patil, N, Parrini, V, Mcbride, A, Negaard, K, Ratsch, A, Abdelaziz, A, Uribe, J, Peris, A, Sanders, M, Emerson, D, Kamal, M, Povoa, P, Francis, R, Cherif, A, Joseph, S, Di Nardo, M, Heard, M, Kyle, K, Blackwell, R, Biston, P, Jeong, H, Smith, R, Prawira, Y, Montrucchio, G, Garcia, A, Salterain, N, Meyns, B, Moreno, M, Walia, R, Mehta, A, Schweda, A, Supriatna, M, Kirakli, C, Williams, M, Kim, K, Assad, A, Giraldo, E, Karolak, W, Balik, M, Pocock, E, Gajkowski, E, Masafumi, K, Barrett, N, Takeyama, Y, Park, S, Amin, F, Andriyani, F, Sudakevych, S, Vera, M, Cornejo, R, Schwarz, P, Mardini, A, de Paula, T, Neto, A, Villoldo, A, Colafranceschi, A, Iglesias, A, Granjean, J, Melro, L, Romualdo, G, Gaia, D, Souza, H, Galas, F, Mendiluce, R, Sosa, A, Martinez, I, Kurosawa, H, Salgado, J, Hugi-MayrCharbonneau, B, Barzilai, V, Monteiro, V, de Souza, R, Harper, M, Suzuki, H, Adams, C, Brieva, J, Nyale, G, Eltatar, F, Fatani, J, Baeissa, H, Masri, A, Rabie, A, Hui, M, Yamane, M, Jung, H, Margaret, A, Nacpil, N, Ruck, K, Bakken, R, Jara, C, Felton, T, Berra, L, Shah, B, Chakraborty, A, Cardona, M, Capatos, G, Akkanti, B, Orija, A, Jain, H, Ito, A, Housni, B, Low, S, Iihara, K, Chavez, J, Ramanathan, K, Zabert, G, Naidoo, K, Seppelt, I, Vandyk, M, Macdonald, S, Mcgregor, R, Siebenaler, T, Flynn, H, Lofton, K, Aokage, T, Shigemitsu, K, Moscatelli, A, Fiorentino, G, Baumgaertel, M, Mba, S, Assy, J, Hutahaean, A, Roush, H, Sichting, K, Alessandri, F, Burns, D, Salt, G, Garabedian, C, Millar, J, Sim, M, Mattke, A, Mcauley, D, Tadili, J, Frenzel, T, Bar-Lavie, Y, Ortiz, A, Stone, J, Attokaran, A, Farquharson, M, Patel, B, Gunning, D, Baillie, K, Watson, P, Tamai, K, Sajinadiyasa, G, Kanyawati, D, Salgado, M, Sassine, A, Yudo, B, Mccaul, S, Lee, B, Afek, A, Iwashita, Y, Semedi, B, Metiva, J, Van Belle, N, Martin-Loeches, I, Ivatt, L, Woon, C, Kang, H, Smith, T, James, E, Al-Rawas, N, Iwasaki, Y, King-Chung, K, Gudzenko, V, Hugi-Mayr, B, Taccone, F, Perdhana, F, Lamarche, Y, Ribeiro, J, Bradic, N, Van den Bossche, K, Lansink, O, Singh, G, Debeuckelaere, G, Stelfox, H, Yi, C, Elia, J, Tribble, T, Shankar, S, Padmanabhan, R, Hallinan, B, Paoletti, L, Leyva, Y, Fykuda, T, Badulak, J, Koch, J, Hackman, A, Janowaik, L, Hernandez, D, Osofsky, J, Donadello, K, Lawang, A, Fine, J, Davidson, B, Li Bassi G., Gibbons K., Suen J. Y., Dalton H. J., White N., Corley A., Shrapnel S., Hinton S., Forsyth S., Laffey J. G., Fan E., Fanning J. P., Panigada M., Bartlett R., Brodie D., Burrell A., Chiumello D., Elhazmi A., Esperatti M., Grasselli G., Hodgson C., Ichiba S., Luna C., Marwali E., Merson L., Murthy S., Nichol A., Ogino M., Pelosi P., Torres A., Ng P. Y., Fraser J. F., Al-Dabbous T., Alfoudri H., Shamsah M., Elapavaluru S., Berg A., Horn C., Mayasi Y., Schroll S., Meyer D., Velazco J., Ploskanych L., Fikes W., Bagewadi R., Dao M., White H., Ehlers A., Shalabi-McGuire M., Witt T., Grazioli L., Lorini L., Grandin E. W., Nunez J., Reyes T., OBriain D., Hunter S., Ramanan M., Affleck J., Veerendra H. H., Rai S., Russell-Brown J., Nourse M., Joseph M., Mitchell B., Tenzer M., Abe R., Cho H. J., Jeong I. S., Rahman N., Kakar V., Brozzi N., Mehkri O., Krishnan S., Duggal A., Houltham S., Graf J., Diaz R., Orrego R., Delgado C., Gonzalez J., Sanchez M. S., Piagnerelli M., Sarrazin J. V., Zabert A. /P. G., Espinosa L., Delgado P., Delgado V., Rincon D. F. B., Yanten A. M. M., Duque M. B., Al-Hudaib A., Callahan M., Taufik M. A., Wardoyo E. Y., Gunawan M., Trisnaningrum N. S., Irawany V., Rayhan M., Pesenti A., Zanella A., Leone M., Coppola S., Colombo S., Antonelli M., Carelli S., Grieco D. L., Asaki M., Hoshino K., Salazar L., Duarte L., McNicholas B., Cosgrave D., McCaffrey J., Bone A., Hakeem Y., Winearls J., Tallott M., Thomson D., Arnold-Day C., Cupido J., Miller M., Seymore L., van Straaten D., Hssain A. A., Aliudin J., Alqahtani A. -R., Mohamed K., Mohamed A., Tan D., Villanueva J., Zaqout A., Kurtzman E., Ademi A., Dobrita A., El Aoudi K., Segura J., Giwangkancana G., Ohshimo S., Hitoshi S., Osatnik J., Joosten A., Yang M., Motos A., Arancibia F., Williams V., Noel A., Luque N., Trung T. H., Yacoub S., Fantini M., Garcia R. N. J., Alvarez E. C., Greti A., Ceccato A., Sanchez A., Vazquez A. L., Roche-Campo F., Franch-Llasat D., Tuazon D., Amato M., Cassimiro L., Pola F., Ribeiro F., Fonseca G., Dalton H., Desai M., Osborn E., Deeb H., Arcadipane A., Martucci G., Panarello G., Vitiello C., Bianco C., Occhipinti G., Rossetti M., Cuffaro R., Cho S. -M., Shimizu H., Moriyama N., Kim J. -B., Kitamura N., Gebauer J., Yokoyama T., Al-Fares A., Buabbas S., Alamad E., Alawadhi F., Alawadi K., Tanaka H., Hashimoto S., Yamazaki M., Oh T. -H., Epler M., Forney C., Kruse L., Feister J., Williamson J., Grobengieser K., Gnall E., Golden S., Caroline M., Shapiro T., Karaj C., Thome L., Sher L., Vanderland M., Welch M., McDermott S., Brain M., Mineall S., Kimura D., Brazzi L., Sales G., Ogston T., Nagpal D., Fischer K., Lorusso R., Rangappa R., Appu A., Carton E. G., Sen A., Palacios A., Rainey D., Samoukoviv G., Campisi J., Durham L., Neumann E., Seefeldt C., Falcucci O., Emmrich A., Guy J., Johns C., Potzner K., Zimmermann C., Espinal A., Buchtele N., Schwameis M., Stecher S. -S., Singh D., Barnikel M., Arenz L., Zaaqoq A., Galloway L. A., Merley C., Csete M., Quesada L., Saba I., Kasugai D., Hiraiwa H., Tanaka T., Purnama Y., Dewayanti S. R., Juzar D. A., Siagian D., Chen Y. -S., Ratsep I., Oigus G., Erikson K., Post A. -M., Enneveer L., Sillaots P., Manetta F., Mihelis E., Sarmiento I. C., Narasimhan M., Varrone M., Komats M., Garcia-Diaz J., Harmon C., Satyapriya S. V., Bhatt A., Mokadam N. A., Uribe A., Gonzalez A., Shi H., McKeown J., Pasek J., Fiorda J., Echeverria M., Moreno R., Zakhary B., Cavana M., Cucino A., Foti G., Giani M., Russotto V., Castagna V., DellAmore A., Navalesi P., Shum H. -P., Vuysteke A., Usman A., Acker A., Smood B., Mergler B., Sertic F., Subramanian M., Sperry A., Rizer N., Burhan E., Rasmin M., Akmal E., Sitompul F., Lolong N., Naivedh B., Erickson S., Barrett P., Dean D., Daugherty J., Loforte A., Khan I., Abraar Quraishi M., DeSantis O., So D., Kandamby D., Mandei J. M., Natanael H., YudhaLantang E., Lantang A., Wijaya S. O., Jung A., Ng G., Ng W. Y., Fang S., Tabah A., Ratcliffe M., Duroux M., Adachi S., Nakao S., Blanco P., Prieto A., Sanchez J., Nicholson M., Butt W., Serratore A., Delzoppo C., Janin P., Yarad E., Totaro R., Coles J., Pujo B., Balk R., Vissing A., Kapania E., Hays J., Fox S., Yantosh G., Mishin P., Yuliarto S., Hari Santoso K., Djajalaksana S., Fatoni A. Z., Fukuda M., Liu K., Battaglini D., Jimenez J. F. M., Bastos D., Gaiao S., Rusmawatiningtyas D., Buchner J., Cho Y. -J., Lee S. H., Kawasaki T., Munshi L., Sakiyalak P., Nitayavardhana P., Seitz T., Arora R., Kent D., Marino D., Parwar S., Cheng A., Miller J., Fujitani S., Shimizu N., Madhok J., Owyang C., Buscher H., Reynolds C., Maasikas O., Beljantsev A., Mihnovits V., Akimoto T., Aizawa M., Horibe K., Onodera R., Young M., George T., Shekar K., McGuinness N., Irvine L., Flynn B., Endo T., Sugiyama K., Shimizu K., Exconde K., Lussier L., Lotz G., Malfertheiner M., Maier L., Dreier E., Kusumastuti N. P., McCloskey C., Dabaliz A. -A., Elshazly T. B., Smith J., Szuldrzynski K. S., Bielanski P., Wille K., Parhar K. K. S., Fiest K. M., Codan C., Shahid A., Fayed M., Evans T., Garcia R., Gutierrez A., Song T., Rose R., Bennett S., Richardson D., Peek G., Arora L., Rappapport K., Rudolph K., Sibenaller Z., Stout L., Walter A., Herr D., Vedadi N., Thompson S., Sindt L., Rajnic S., Ewald C., Hoffman J., Ying X., Kennedy R., Griffee M., Ciullo A., Kida Y., Roca R. F., Riera J. I., Contreras S., Alegre C., Kay C., Fischer I., Renner E., Taniguci H., Bassi G. L., Suen J., Barnett A., Pearse I., Abbate G., Hassan H., Heinsar S., Karnik V. A., Ki K., ONeill H. F., Obonyo N., Pimenta L. P., Reid J. D., Sato K., Vuorinen A., Wildi K. S., Wood E. S., Yerkovich S., Lee J., Plotkin D., Citarella B. W., Hartley E., Lubis B., Ikeyama T., Bhaskar B., Jung J. -S., McGuinness S., Eastwood G., Marta S. R., Guarracino F., Gerle S., Coxon E., Claro B., Loverde D., Patil N., Parrini V., McBride A., Negaard K., Ratsch A., Abdelaziz A., Uribe J. D., Peris A., Sanders M., Emerson D., Kamal M., Povoa P., Francis R., Cherif A., Joseph S., Di Nardo M., Heard M., Kyle K., Blackwell R. A., Biston P., Jeong H. W., Smith R., Prawira Y., Montrucchio G., Garcia A. H., Salterain N., Meyns B., Moreno M., Walia R., Mehta A., Schweda A., Supriatna M., Kirakli C., Williams M., Kim K. H., Assad A., Giraldo E., Karolak W., Balik M., Pocock E., Gajkowski E., Masafumi K., Barrett N., Takeyama Y., Park S., Amin F., Andriyani F. M., Sudakevych S., Vera M., Cornejo R., Schwarz P., Mardini A. C., de Paula T., Neto A. S., Villoldo A., Colafranceschi A. S., Iglesias A. U., Granjean J., Melro L. M. G., Romualdo G. F., Gaia D., Souza H., Galas F., Mendiluce R. M., Sosa A., Martinez I., Kurosawa H., Salgado J., Hugi-MayrCharbonneau B. E., Barzilai V. S., Monteiro V., de Souza R. R., Harper M., Suzuki H., Adams C., Brieva J., Nyale G., Eltatar F. S., Fatani J., Baeissa H., Masri A. A., Rabie A., Hui M. Y., Yamane M., Jung H., Margaret A. 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C., Gudzenko V., Hugi-Mayr B., Taccone F., Perdhana F., Lamarche Y., Ribeiro J. M., Bradic N., Van den Bossche K., Lansink O., Singh G., Debeuckelaere G., Stelfox H. T., Yi C., Elia J., Tribble T., Shankar S., Padmanabhan R., Hallinan B., Paoletti L., Leyva Y., Fykuda T., Badulak J., Koch J., Hackman A., Janowaik L., Hernandez D., Osofsky J., Donadello K., Lawang A., Fine J., Davidson B., Vazquez A. O. R., Li Bassi, G, Gibbons, K, Suen, J, Dalton, H, White, N, Corley, A, Shrapnel, S, Hinton, S, Forsyth, S, Laffey, J, Fan, E, Fanning, J, Panigada, M, Bartlett, R, Brodie, D, Burrell, A, Chiumello, D, Elhazmi, A, Esperatti, M, Grasselli, G, Hodgson, C, Ichiba, S, Luna, C, Marwali, E, Merson, L, Murthy, S, Nichol, A, Ogino, M, Pelosi, P, Torres, A, Ng, P, Fraser, J, Al-Dabbous, T, Alfoudri, H, Shamsah, M, Elapavaluru, S, Berg, A, Horn, C, Mayasi, Y, Schroll, S, Meyer, D, Velazco, J, Ploskanych, L, Fikes, W, Bagewadi, R, Dao, M, White, H, Ehlers, A, Shalabi-McGuire, M, Witt, T, Grazioli, L, Lorini, L, Grandin, E, Nunez, J, Reyes, T, Obriain, D, Hunter, S, Ramanan, M, Affleck, J, Veerendra, H, Rai, S, Russell-Brown, J, Nourse, M, Joseph, M, Mitchell, B, Tenzer, M, Abe, R, Cho, H, Jeong, I, Rahman, N, Kakar, V, Brozzi, N, Mehkri, O, Krishnan, S, Duggal, A, Houltham, S, Graf, J, Diaz, R, Orrego, R, Delgado, C, Gonzalez, J, Sanchez, M, Piagnerelli, M, Sarrazin, J, Zabert, A, Espinosa, L, Delgado, P, Delgado, V, Rincon, D, Yanten, A, Duque, M, Al-Hudaib, A, Callahan, M, Taufik, M, Wardoyo, E, Gunawan, M, Trisnaningrum, N, Irawany, V, Rayhan, M, Pesenti, A, Zanella, A, Leone, M, Coppola, S, Colombo, S, Antonelli, M, Carelli, S, Grieco, D, Asaki, M, Hoshino, K, Salazar, L, Duarte, L, Mcnicholas, B, Cosgrave, D, Mccaffrey, J, Bone, A, Hakeem, Y, Winearls, J, Tallott, M, Thomson, D, Arnold-Day, C, Cupido, J, Miller, M, Seymore, L, van Straaten, D, Hssain, A, Aliudin, J, Alqahtani, A, Mohamed, K, Mohamed, A, Tan, D, Villanueva, J, Zaqout, A, Kurtzman, E, Ademi, A, Dobrita, A, El Aoudi, K, Segura, J, Giwangkancana, G, Ohshimo, S, Hitoshi, S, Osatnik, J, Joosten, A, Yang, M, Motos, A, Arancibia, F, Williams, V, Noel, A, Luque, N, Trung, T, Yacoub, S, Fantini, M, Garcia, R, Alvarez, E, Greti, A, Ceccato, A, Sanchez, A, Vazquez, A, Roche-Campo, F, Franch-Llasat, D, Tuazon, D, Amato, M, Cassimiro, L, Pola, F, Ribeiro, F, Fonseca, G, Desai, M, Osborn, E, Deeb, H, Arcadipane, A, Martucci, G, Panarello, G, Vitiello, C, Bianco, C, Occhipinti, G, Rossetti, M, Cuffaro, R, Cho, S, Shimizu, H, Moriyama, N, Kim, J, Kitamura, N, Gebauer, J, Yokoyama, T, Al-Fares, A, Buabbas, S, Alamad, E, Alawadhi, F, Alawadi, K, Tanaka, H, Hashimoto, S, Yamazaki, M, Oh, T, Epler, M, Forney, C, Kruse, L, Feister, J, Williamson, J, Grobengieser, K, Gnall, E, Golden, S, Caroline, M, Shapiro, T, Karaj, C, Thome, L, Sher, L, Vanderland, M, Welch, M, Mcdermott, S, Brain, M, Mineall, S, Kimura, D, Brazzi, L, Sales, G, Ogston, T, Nagpal, D, Fischer, K, Lorusso, R, Rangappa, R, Appu, A, Carton, E, Sen, A, Palacios, A, Rainey, D, Samoukoviv, G, Campisi, J, Durham, L, Neumann, E, Seefeldt, C, Falcucci, O, Emmrich, A, Guy, J, Johns, C, Potzner, K, Zimmermann, C, Espinal, A, Buchtele, N, Schwameis, M, Stecher, S, Singh, D, Barnikel, M, Arenz, L, Zaaqoq, A, Galloway, L, Merley, C, Csete, M, Quesada, L, Saba, I, Kasugai, D, Hiraiwa, H, Tanaka, T, Purnama, Y, Dewayanti, S, Ardiyan, Juzar, D, Siagian, D, Chen, Y, Ratsep, I, Oigus, G, Erikson, K, Post, A, Enneveer, L, Sillaots, P, Manetta, F, Mihelis, E, Sarmiento, I, Narasimhan, M, Varrone, M, Komats, M, Garcia-Diaz, J, Harmon, C, Satyapriya, S, Bhatt, A, Mokadam, N, Uribe, A, Gonzalez, A, Shi, H, Mckeown, J, Pasek, J, Fiorda, J, Echeverria, M, Moreno, R, Zakhary, B, Cavana, M, Cucino, A, Foti, G, Giani, M, Russotto, V, Castagna, V, Dellamore, A, Navalesi, P, Shum, H, Vuysteke, A, Usman, A, Acker, A, Smood, B, Mergler, B, Sertic, F, Subramanian, M, Sperry, A, Rizer, N, Burhan, E, Rasmin, M, Akmal, E, Sitompul, F, Lolong, N, Naivedh, B, Erickson, S, Barrett, P, Dean, D, Daugherty, J, Loforte, A, Khan, I, Abraar Quraishi, M, Desantis, O, So, D, Kandamby, D, Mandei, J, Natanael, H, Yudhalantang, E, Lantang, A, Wijaya, S, Jung, A, Ng, G, Ng, W, Fang, S, Tabah, A, Ratcliffe, M, Duroux, M, Adachi, S, Nakao, S, Blanco, P, Prieto, A, Sanchez, J, Nicholson, M, Butt, W, Serratore, A, Delzoppo, C, Janin, P, Yarad, E, Totaro, R, Coles, 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Sibenaller, Z, Stout, L, Walter, A, Herr, D, Vedadi, N, Thompson, S, Sindt, L, Rajnic, S, Ewald, C, Hoffman, J, Ying, X, Kennedy, R, Griffee, M, Ciullo, A, Kida, Y, Roca, R, Riera, J, Contreras, S, Alegre, C, Kay, C, Fischer, I, Renner, E, Taniguci, H, Bassi, G, Barnett, A, Pearse, I, Abbate, G, Hassan, H, Heinsar, S, Karnik, V, Ki, K, Oneill, H, Obonyo, N, Pimenta, L, Reid, J, Sato, K, Vuorinen, A, Wildi, K, Wood, E, Yerkovich, S, Lee, J, Plotkin, D, Citarella, B, Hartley, E, Lubis, B, Ikeyama, T, Bhaskar, B, Jung, J, Mcguinness, S, Eastwood, G, Marta, S, Guarracino, F, Gerle, S, Coxon, E, Claro, B, Loverde, D, Patil, N, Parrini, V, Mcbride, A, Negaard, K, Ratsch, A, Abdelaziz, A, Uribe, J, Peris, A, Sanders, M, Emerson, D, Kamal, M, Povoa, P, Francis, R, Cherif, A, Joseph, S, Di Nardo, M, Heard, M, Kyle, K, Blackwell, R, Biston, P, Jeong, H, Smith, R, Prawira, Y, Montrucchio, G, Garcia, A, Salterain, N, Meyns, B, Moreno, M, Walia, R, Mehta, A, Schweda, A, Supriatna, M, Kirakli, C, Williams, M, Kim, K, Assad, A, Giraldo, E, Karolak, W, Balik, M, Pocock, E, Gajkowski, E, Masafumi, K, Barrett, N, Takeyama, Y, Park, S, Amin, F, Andriyani, F, Sudakevych, S, Vera, M, Cornejo, R, Schwarz, P, Mardini, A, de Paula, T, Neto, A, Villoldo, A, Colafranceschi, A, Iglesias, A, Granjean, J, Melro, L, Romualdo, G, Gaia, D, Souza, H, Galas, F, Mendiluce, R, Sosa, A, Martinez, I, Kurosawa, H, Salgado, J, Hugi-MayrCharbonneau, B, Barzilai, V, Monteiro, V, de Souza, R, Harper, M, Suzuki, H, Adams, C, Brieva, J, Nyale, G, Eltatar, F, Fatani, J, Baeissa, H, Masri, A, Rabie, A, Hui, M, Yamane, M, Jung, H, Margaret, A, Nacpil, N, Ruck, K, Bakken, R, Jara, C, Felton, T, Berra, L, Shah, B, Chakraborty, A, Cardona, M, Capatos, G, Akkanti, B, Orija, A, Jain, H, Ito, A, Housni, B, Low, S, Iihara, K, Chavez, J, Ramanathan, K, Zabert, G, Naidoo, K, Seppelt, I, Vandyk, M, Macdonald, S, Mcgregor, R, Siebenaler, T, Flynn, H, Lofton, K, Aokage, T, Shigemitsu, K, Moscatelli, A, Fiorentino, G, 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A., Uribe A., Gonzalez A., Shi H., McKeown J., Pasek J., Fiorda J., Echeverria M., Moreno R., Zakhary B., Cavana M., Cucino A., Foti G., Giani M., Russotto V., Castagna V., DellAmore A., Navalesi P., Shum H. -P., Vuysteke A., Usman A., Acker A., Smood B., Mergler B., Sertic F., Subramanian M., Sperry A., Rizer N., Burhan E., Rasmin M., Akmal E., Sitompul F., Lolong N., Naivedh B., Erickson S., Barrett P., Dean D., Daugherty J., Loforte A., Khan I., Abraar Quraishi M., DeSantis O., So D., Kandamby D., Mandei J. M., Natanael H., YudhaLantang E., Lantang A., Wijaya S. O., Jung A., Ng G., Ng W. Y., Fang S., Tabah A., Ratcliffe M., Duroux M., Adachi S., Nakao S., Blanco P., Prieto A., Sanchez J., Nicholson M., Butt W., Serratore A., Delzoppo C., Janin P., Yarad E., Totaro R., Coles J., Pujo B., Balk R., Vissing A., Kapania E., Hays J., Fox S., Yantosh G., Mishin P., Yuliarto S., Hari Santoso K., Djajalaksana S., Fatoni A. Z., Fukuda M., Liu K., Battaglini D., Jimenez J. F. 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M., Codan C., Shahid A., Fayed M., Evans T., Garcia R., Gutierrez A., Song T., Rose R., Bennett S., Richardson D., Peek G., Arora L., Rappapport K., Rudolph K., Sibenaller Z., Stout L., Walter A., Herr D., Vedadi N., Thompson S., Sindt L., Rajnic S., Ewald C., Hoffman J., Ying X., Kennedy R., Griffee M., Ciullo A., Kida Y., Roca R. F., Riera J. I., Contreras S., Alegre C., Kay C., Fischer I., Renner E., Taniguci H., Bassi G. L., Suen J., Barnett A., Pearse I., Abbate G., Hassan H., Heinsar S., Karnik V. A., Ki K., ONeill H. F., Obonyo N., Pimenta L. P., Reid J. D., Sato K., Vuorinen A., Wildi K. S., Wood E. S., Yerkovich S., Lee J., Plotkin D., Citarella B. W., Hartley E., Lubis B., Ikeyama T., Bhaskar B., Jung J. -S., McGuinness S., Eastwood G., Marta S. R., Guarracino F., Gerle S., Coxon E., Claro B., Loverde D., Patil N., Parrini V., McBride A., Negaard K., Ratsch A., Abdelaziz A., Uribe J. D., Peris A., Sanders M., Emerson D., Kamal M., Povoa P., Francis R., Cherif A., Joseph S., Di Nardo M., Heard M., Kyle K., Blackwell R. A., Biston P., Jeong H. W., Smith R., Prawira Y., Montrucchio G., Garcia A. H., Salterain N., Meyns B., Moreno M., Walia R., Mehta A., Schweda A., Supriatna M., Kirakli C., Williams M., Kim K. H., Assad A., Giraldo E., Karolak W., Balik M., Pocock E., Gajkowski E., Masafumi K., Barrett N., Takeyama Y., Park S., Amin F., Andriyani F. M., Sudakevych S., Vera M., Cornejo R., Schwarz P., Mardini A. C., de Paula T., Neto A. S., Villoldo A., Colafranceschi A. S., Iglesias A. U., Granjean J., Melro L. M. G., Romualdo G. F., Gaia D., Souza H., Galas F., Mendiluce R. M., Sosa A., Martinez I., Kurosawa H., Salgado J., Hugi-MayrCharbonneau B. E., Barzilai V. S., Monteiro V., de Souza R. R., Harper M., Suzuki H., Adams C., Brieva J., Nyale G., Eltatar F. S., Fatani J., Baeissa H., Masri A. A., Rabie A., Hui M. Y., Yamane M., Jung H., Margaret A. M., Nacpil N., Ruck K., Bakken R., Jara C., Felton T., Berra L., Shah B., Chakraborty A., Cardona M., Capatos G., Akkanti B., Orija A., Jain H., Ito A., Housni B., Low S., Iihara K., Chavez J., Ramanathan K., Zabert G., Naidoo K., Seppelt I., VanDyk M., MacDonald S., McGregor R., Siebenaler T., Flynn H., Lofton K., Aokage T., Shigemitsu K., Moscatelli A., Fiorentino G., Baumgaertel M., Mba S. E., Assy J., Hutahaean A., Roush H., Sichting K. A., Alessandri F., Burns D., Salt G., Garabedian C. P., Millar J., Sim M., Mattke A., McAuley D., Tadili J., Frenzel T., Bar-Lavie Y., Ortiz A. B., Stone J., Attokaran A., Farquharson M., Patel B., Gunning D., Baillie K., Watson P., Tamai K., Sajinadiyasa G. K., Kanyawati D., Salgado M., Sassine A., Yudo B., McCaul S., Lee B., Lee S. M., Afek A., Iwashita Y., Semedi B. P., Metiva J., Van Belle N., Martin-Loeches I., Ivatt L., Woon C. Y., Kang H. M., Smith T., James E., Al-Rawas N., Iwasaki Y., King-Chung K. C., Gudzenko V., Hugi-Mayr B., Taccone F., Perdhana F., Lamarche Y., Ribeiro J. M., Bradic N., Van den Bossche K., Lansink O., Singh G., Debeuckelaere G., Stelfox H. T., Yi C., Elia J., Tribble T., Shankar S., Padmanabhan R., Hallinan B., Paoletti L., Leyva Y., Fykuda T., Badulak J., Koch J., Hackman A., Janowaik L., Hernandez D., Osofsky J., Donadello K., Lawang A., Fine J., Davidson B., and Vazquez A. O. R.

Abstract

Background: The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods: We analyzed a convenience sample of patients with COVID-19 and moderate-to-severe ARDS, admitted to 244 intensive care units within the COVID-19 Critical Care Consortium, from February 1, 2020, through October 31, 2021. Patients undergoing at least 2 days and up to 3 consecutive days of NMBAs (NMBA treatment), within 48 h from commencement of IMV were compared with subjects who did not receive NMBAs or only upon commencement of IMV (control). The primary objective in the PS-matched cohort was comparison between groups in 90-day in-hospital mortality, assessed through Cox proportional hazard modeling. Secondary objectives were comparisons in the numbers of ventilator-free days (VFD) between day 1 and day 28 and between day 1 and 90 through competing risk regression. Results: Data from 1953 patients were included. After propensity score matching, 210 cases from each group were well matched. In the PS-matched cohort, mean (± SD) age was 60.3 ± 13.2 years and 296 (70.5%) were male and the most common comorbidities were hypertension (56.9%), obesity (41.1%), and diabetes (30.0%). The unadjusted hazard ratio (HR) for death at 90 days in the NMBA treatment vs control group was 1.12 (95% CI 0.79, 1.59, p = 0.534). After adjustment for smoking habit and critical therapeutic covariates, the HR was 1.07 (95% CI 0.72, 1.61, p = 0.729). At 28 days, VFD were 16 (IQR 0–25) and 25 (IQR 7–26) in the NMBA treatment and control groups, respectively (sub-hazard ratio 0.82, 95% CI 0.67, 1.00, p = 0.055). At 90 days, VFD were 77 (IQR 0–87) and 87 (IQR 0–88) (sub-hazard ratio 0.86 (95% CI 0.69, 1.07; p =

Published
2022

64. When CLIP meets cross-modal hashing retrieval: A new strong baseline

Author

Xia, X, Dong, G, Li, F, Zhu, L, Ying, X, Xia, X, Dong, G, Li, F, Zhu, L, and Ying, X

Abstract

Recent days witness significant progress in various multi-modal tasks made by Contrastive Language-Image Pre-training (CLIP), a multi-modal large-scale model that learns visual representations from natural language supervision. However, the potential effects of CLIP on cross-modal hashing retrieval has not been investigated yet. In this paper, we for the first time explore the effects of CLIP on cross-modal hashing retrieval performance and propose a simple but strong baseline Unsupervised Contrastive Multi-modal Fusion Hashing network (UCMFH). We first extract the off-the-shelf visual and linguistic features from the CLIP model, as the input sources for cross-modal hashing functions. To further mitigate the semantic gap between the image and text features, we design an effective contrastive multi-modal learning module that leverages a multi-modal fusion transformer encoder supervising by a contrastive loss, to enhance modality interaction while improving the semantic representation of each modality. Furthermore, we design a contrastive hash learning module to produce high-quality modal-correlated hash codes. Experiments show that significant performance improvement can be made by our simple new unsupervised baseline UCMFH compared with state-of-the-art supervised and unsupervised cross-modal hashing methods. Also, our experiments demonstrate the remarkable performance of CLIP features on cross-modal hashing retrieval task compared to deep visual and linguistic features used in existing state-of-the-art methods. The source codes for our approach is publicly available at: https://github.com/XinyuXia97/UCMFH.

Published
2023

69. Gated graph convolutional network with enhanced representation and joint attention for distant supervised heterogeneous relation extraction

Author

Ying, X, Meng, Z, Zhao, M, Yu, M, Pan, S, and Li, X

Subjects
0804 Data Format, 0805 Distributed Computing, 0806 Information Systems, Computer Networks and Communications, Hardware and Architecture, Software, Information Systems
Abstract

Distant supervised relation extraction which is to extract heterogeneous relations from text data without manual annotation has been widely used in decision-making tasks such as question answering or recommendation system. However, existing distant supervised methods inevitably accompany with the wrong labelling problem. They typically use attention mechanism to select valid instances while ignore the core of relation extraction, i.e., entity pairs and relations. To address this problem, in this paper we incorporate enhanced representations into a gated graph convolutional network to enrich the background information and further improve the attention mechanism to focus on the most relevant relation. Specifically, in the proposed framework, 1) we introduce a triplet enhanced word representation method to focus on not only position information but also entity pair and implicit relation information in a sentence; 2) we use a Gated Rectified Linear Units (GRLU) module to integrate triplet information into an instance so as to achieve the purpose of enhancing sentence-level features; and 3) we employ sentence-relation joint attention over multiple instances and multiple relations, which is expected to dynamically reduce the weights of those noisy instances and enhance the bag representation. Extensive experiments on two popular datasets show that our model achieves significant improvement over all baseline methods.

Published
2021
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73. Stroke Prevention in Atrial Fibrillation

Author

Tze Fan Chao, Juqian Zhang, Ying X Gue, Tatjana S. Potpara, Gregory Y.H. Lip, and Hugh Calkins

Subjects
medicine.medical_specialty, business.industry, Warfarin, MEDLINE, Anticoagulants, Atrial fibrillation, medicine.disease, Comorbidity, Integrated care, Stroke, Systematic review, Risk Factors, Diabetes mellitus, Atrial Fibrillation, Humans, Medicine, Cardiology and Cardiovascular Medicine, business, Intensive care medicine, medicine.drug
Abstract

Atrial fibrillation (AF) is the commonest sustained cardiac rhythm disorder associated with an increased risk of stroke and systemic embolic events. The prevention of stroke using oral anticoagulants has been a pivotal component of AF management. The purpose of this review is to summarize recent advances in the treatment and prevention of stroke in AF over the last 5 years. We performed a comprehensive structured literature search using MEDLINE for publications from 11th March 2015 through to 31st December 2020. We focused mainly on primarily published research articles and systematic reviews including updates in different international guidelines. We found that improved awareness and detection of AF and use of clinical risk stratification are central to the identification of patients at risk of stroke who would benefit from oral anticoagulation. The recommendation of non-vitamin K antagonist oral anticoagulants over warfarin in both efficacy and safety perspective is represented in all international guidelines. Beyond stroke prevention, there is a move to more holistic or integrated care management of AF, which has been shown to improve outcomes. We conclude that stroke prevention remains a dominant part of the management of patients with AF. Not all stroke risk factors carry equal weight, and many require additional scrutiny (e.g. severity of CAD, type of diabetes, duration of hypertension). The utilization of clinical risk scores to help decision-making should take into account that these scores are mere simplification tools to aid decision-making and the additional clinical benefit with more complex risk scores and addition of biomarkers is limited. Also, stroke and bleeding risks are dynamic and require regular review. Instead of arbitrarily categorizing patients into (artificial) low, moderate, and high stroke risk strata, anticoagulation should be offered to all patients with AF unless they are low risk with no risk factors for stroke. Stroke prevention is also part of the proactive, integrated care approach to holistic management of patients with AF, which can be simplified in the ABC (Atrial fibrillation Better Care) pathway: ‘A’ Avoid stroke/Anticoagulation; ‘B’ Better symptom management emphasising patient-centred symptom directed decisions on rate or rhythm control strategies; and ‘C’ refers to Cardiovascular risk and comorbidity optimization, including lifestyle changes and attention to patient values and preferences, as well as the psychological morbidity associated with AF.

Published
2022
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77. An uncommon manifestation of shock: Takotsubo syndrome

Author

Ying X Gue, Sanjay S Bhandari, and Mubarak Ahamed

Subjects
reverse Takotsubo cardiomyopathy, echocardiography, left ventricular outflow tract obstruction, mitral annular systolic displacement, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

76-year-old female presented following an episode of collapse. She was hypotensive with the paramedics and remained refractory despite fluid resuscitation. Her initial baseline tests revealed an elevated troponin; she subsequently underwent a coronary angiogram that showed mild coronary artery disease. Left ventriculogram was performed, which showed abnormal mid-wall ballooning and severely impaired systolic function, characteristic of Takotsubo syndrome. Echocardiogram confirmed the presence of diagnosis and presence of left ventricular outflow tract obstruction with high gradient. She was initiated on medical heart failure therapy and improved. Follow-up investigations after 2 months showed complete resolution of systolic dysfunction and symptoms.

Published
2017
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78. Critical aortic stenosis presenting as STEMI

Author

Ying X Gue, Sanjay S Bhandari, and Damian J Kelly

Subjects
aortic stenosis, myocardial infarction, echocardiogram, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

A 73-year-old male was brought into hospital with chest pain and inferior ST elevation on ECG. The patient immediately proceeded to the catheter lab for primary percutaneous coronary intervention. Angiography did not identify any culprit lesions to account for the patient’s electrocardiographic changes and ongoing symptoms of chest pain. Bedside echocardiography revealed critical aortic stenosis. Intra-aortic balloon pump (IABP) was inserted, resulting in resolution of chest pain and ST-segment changes. The patient underwent successful aortic valve (AV) replacement without the need for coronary intervention. This is a rare presentation of critical aortic stenosis (AS) presenting as ST-segment elevation myocardial infarction (STEMI).

Published
2017
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80. Oral Presentation No. 019 Bi-directional cross talk between coagulation, fibrinolysis and inflammatory pathways in patients with ST-segment elevation myocardial infarction

Author

Rahim Kanji, Ying X Gue, Mohammed F Farag, Nicola J Mutch, and Diana A Gorog

Subjects
Physiology, Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Background Impaired endogenous fibrinolysis is a risk factor for recurrent cardiovascular events in patients with acute coronary syndrome (ACS). Ongoing inflammation is also an adverse prognostic risk factor. While inflammatory markers are elevated in patients presenting with ST-segment elevation myocardial infarction (STEMI), whether there is a direct relationship between markers of inflammation at presentation, and the effectiveness of endogenous fibrinolysis in this setting, is unclear. Our study aimed to assess the relationship between markers of inflammation, coagulation and fibrinolysis, in patients with STEMI. Material and methods We conducted a prospective, observational study in consecutive patients presenting with STEMI. Blood was drawn on admission after dual antiplatelet therapy loading, but before administration of anticoagulants. The sample was immediately tested to assess endogenous fibrinolysis using the point-of-care Global Thrombosis Test. In addition, blood samples were tested for leucocyte and neutrophil count, neutrophil-to-leucocyte ratio (NLR), platelet-to-leucocyte ratio (PLR), fibrinogen, standard coagulation markers and high sensitivity C-reactive protein (hs-CRP). Results and conclusions The cohort consisted of 129 patients (aged 66 ± 13 years, 78% male). Whole blood endogenous fibrinolysis time correlated with fibrinogen (r = 0.300, P = 0.001) and hs-CRP (r = 0.236, P = 0.011). Hs-CRP correlated with fibrinogen (r = 0.631, P < 0.001). There was no relationship between whole blood lysis time and leucocyte count, NLR, PLR, international normalised ratio or activated partial thromboplastin time. The effectiveness of endogenous fibrinolysis in whole blood is related to fibrinogen and hs-CRP levels. Our findings strengthen the evidence for bi-directional cross talk between coagulation, fibrinolysis and inflammatory pathways, providing mechanistic insights that could help guide pharmacological strategies to treat hypofibrinolysis.

Published
2022
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82. Virus reduction neutralization test and LI-COR microneutralization assay bridging and WHO international standard calibration studies for respiratory syncytial virus

Author

Dengyun Sun, Ying X Homan, Joseph M Antonello, Danila Giacone, Leah Bogardus, Yuhua Zhang, Wen Feng, Ivette C Caro-Aguilar, Amy Hsu, Shara Dellatore, and Melissa C Whiteman

Subjects
Medical Laboratory Technology, Vaccines, Neutralization Tests, Clinical Biochemistry, Calibration, General Medicine, General Pharmacology, Toxicology and Pharmaceutics, World Health Organization, Antibodies, Neutralizing, Analytical Chemistry, Respiratory Syncytial Viruses
Abstract

Background: Respiratory syncytial virus (RSV) vaccine is an unmet medical need. The virus reduction neutralization test (VRNT) was developed to replace the LI-COR microneutralization assay to measure RSV neutralization titers. Methods: A bridging study using selected V171 phase I samples and calibration studies using the WHO international standard antiserum to RSV were performed to compare VRNT and LI-COR. Results: From the bridging study, we showed good concordance between VRNT and LI-COR titers, and similar post-/prevaccination titer ratios. From the calibration studies, we can convert VRNT and LI-COR titers into similar IU/ml. Conclusion: The VRNT and LI-COR microneutralization assay correlate well and the titers can be standardized as similar IU/ml, enabling direct comparison of titers from different assays.

Published
2022

83. Antithrombotic Therapy in Atrial Fibrillation and Coronary Artery Disease:Does Less Mean More?

Author

Ying X, Gue, Diana A, Gorog, and Gregory Y H, Lip

Subjects
Fibrinolytic Agents, Atrial Fibrillation, Anticoagulants, Humans, Coronary Artery Disease, Cardiology and Cardiovascular Medicine, Platelet Aggregation Inhibitors, Original Investigation
Abstract

IMPORTANCE: Appropriate regimens of antithrombotic therapy for patients with atrial fibrillation (AF) and coronary artery disease (CAD) have not yet been established. OBJECTIVE: To compare the total number of thrombotic and/or bleeding events between rivaroxaban monotherapy and combined rivaroxaban and antiplatelet therapy in such patients. DESIGN, SETTING, AND PARTICIPANTS: This was a post hoc secondary analysis of the Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease (AFIRE) open-label, randomized clinical trial. This multicenter analysis was conducted from February 23, 2015, to July 31, 2018. Patients with AF and stable CAD who had undergone percutaneous coronary intervention or coronary artery bypass grafting 1 or more years earlier or who had angiographically confirmed CAD not requiring revascularization were enrolled. Data were analyzed from September 1, 2020, to March 26, 2021. INTERVENTIONS: Rivaroxaban monotherapy or combined rivaroxaban and antiplatelet therapy. MAIN OUTCOMES AND MEASURES: The total incidence of thrombotic, bleeding, and fatal events was compared between the groups. Cox regression analyses were used to estimate the risk of subsequent events in the 2 groups, with the status of thrombotic or bleeding events that had occurred by the time of death used as a time-dependent variable. RESULTS: A total of 2215 patients (mean [SD] age, 74 [8.2] years; 1751 men [79.1%]) were included in the modified intention-to-treat analysis. The total event rates for the rivaroxaban monotherapy group (1107 [50.0%]) and the combination-therapy group (1108 [50.0%]) were 12.2% (135 of 1107) and 19.2% (213 of 1108), respectively, during a median follow-up of 24.1 (IQR, 17.3-31.5) months. The mortality rate was 3.7% (41 of 1107) in the monotherapy group and 6.6% (73 of 1108) in the combination-therapy group. Rivaroxaban monotherapy was associated with a lower risk of total events compared with combination therapy (hazard ratio, 0.62; 95% CI, 0.48-0.80; P

Published
2022
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84. In situ precipitation: a novel approach for preparation of iron-oxide magnetoliposomes

Author

Xia S, Li P, Chen Q, Armah M, Ying X, Wu J, and Lai J

Subjects
Medicine (General), R5-920
Abstract

Shudong Xia,1 Peng Li,1 Qiang Chen,1 Malik Armah,2 Xiaoying Ying,3 Jian Wu,4 Jiangtao Lai51Yiwu Affiliated Hospital, College of Medicine, 2College of Medicine, 3College of Pharmacy, 4College of Nanotechnology, 5First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of ChinaBackground: Conventional methods of preparing magnetoliposomes are complicated and inefficient. A novel approach for magnetoliposomes preparation was investigated in the study reported here.Methods: FeCl3/FeCl2 solutions were hydrated with lipid films to obtain liposome-encapsulated iron ions by ultrasonic dispersion. Non-encapsulated iron ions were removed by dialysis. NH3 · H2O was added to the system to adjust the pH to a critical value. Four different systems were prepared. Each was incubated at a different temperature for a different length of time to facilitate the permeation of NH3 · H2O into the inner phase of the liposomes and the in situ formation of magnetic iron-oxide cores in the liposomes. Single-factor analysis and orthogonal-design experiments were applied to determinate the effects of alkalization pH, temperature, duration, and initial Fe concentration on encapsulation efficiency and drug loading.Results: The magnetoliposomes prepared by in situ precipitation had an average particle size of 168±14 nm, zeta potential of -26.2±1.9 mV and polydispersity index of 0.23±0.06. The iron-oxide cores were confirmed as Fe3O4 by X-ray diffraction and demonstrated a superparamagnetic response. Encapsulation efficiency ranged from 3% to 22%, while drug loading ranged from 0.2 to 1.58 mol Fe/mol lipid. The optimal conditions for in situ precipitation were found to be an alkalization pH of 12, temperature of 60°C, time of 60 minutes, and initial Fe concentration of 100 mM Fe3+ + 50 mM Fe2+.Conclusion: In situ precipitation could be a simple and efficient approach for the preparation of iron-oxide magnetoliposomes.Keywords: magnetoliposomes, in situ precipitation, iron oxide, alkalization, permeability

Published
2014

85. Adherence to the ‘Atrial Fibrillation Better Care’ Pathway in Patients with Atrial Fibrillation: Impact on Clinical Outcomes—A Systematic Review and Meta-Analysis of 285,000 Patients

Author

Ying X Gue, Pil Sung Yang, Monika Kozieł, José Miguel Rivera-Caravaca, Yutao Guo, Wern Yew Ding, Marco Proietti, Giulio Francesco Romiti, Jakub Gumprecht, Danilo Menichelli, Daniele Pastori, and Gregory Y.H. Lip

Subjects
medicine.medical_specialty, Hemorrhage, Subgroup analysis, 030204 cardiovascular system & hematology, outcomes, Lower risk, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Atrial Fibrillation, Humans, Medicine, atrial fibrillation, 030212 general & internal medicine, Stroke, integrated care, business.industry, Anticoagulants, Atrial fibrillation, Hematology, Odds ratio, medicine.disease, Confidence interval, Systematic review, ABC pathway, Meta-analysis, Practice Guidelines as Topic, Critical Pathways, Guideline Adherence, business
Abstract

Objective The ‘Atrial fibrillation Better Care’ (ABC) pathway has been recently proposed as a holistic approach for the comprehensive management of patients with atrial fibrillation (AF). We performed a systematic review of current evidence for the use of the ABC pathway on clinical outcomes. Methods and Results We performed a systematic review and meta-analysis according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. PubMed and EMBASE were searched for studies reporting the prevalence of ABC-pathway-adherent management in AF patients, and its impact on clinical outcomes (all-cause death, cardiovascular death, stroke, and major bleeding). Meta-analysis of odds ratio (OR) was performed with random-effects models; subgroup analysis and meta-regression were performed to account for heterogeneity. Among the eight studies included, we found a pooled prevalence of ABC-adherent management of 21% (95% confidence interval, CI: 13–34%), with a high grade of heterogeneity, explained by the increasing adherence to each ABC criterion. Patients treated according to the ABC pathway showed a lower risk of all-cause death (OR: 0.42; 95% CI: 0.31–0.56), cardiovascular death (OR: 0.37; 95% CI: 0.23–0.58), stroke (OR: 0.55; 95% CI: 0.37–0.82) and major bleeding (OR: 0.69; 95% CI: 0.51–0.94), with moderate heterogeneity. Prevalence of comorbidities was moderators of heterogeneity for all-cause and cardiovascular death, while longer follow-up was associated with increased effectiveness for all outcomes. Conclusion Adherence to the ABC pathway was suboptimal, being adopted in one in every five patients. Adherence to the ABC pathway was associated with a reduction in the risk of major adverse outcomes.

Published
2021
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90. Virus reduction neutralization test and LI-COR microneutralization assay bridging and WHO international standard calibration studies for respiratory syncytial virus

Author

Sun, Dengyun, primary, Homan, Ying X, additional, Antonello, Joseph M, additional, Giacone, Danila, additional, Bogardus, Leah, additional, Zhang, Yuhua, additional, Feng, Wen, additional, Caro-Aguilar, Ivette C, additional, Hsu, Amy, additional, Dellatore, Shara, additional, and Whiteman, Melissa C, additional

Published
2022
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93. Non-Vitamin K Antagonist Oral Anticoagulants Versus Warfarin for Patients With Left Ventricular Thrombus: A Systematic Review and Meta-Analysis

Author

Diana A. Gorog, Ying X Gue, Mohaned Egred, Nikolaos Spinthakis, and Mohamed Farag

Subjects
medicine.medical_specialty, medicine.drug_class, business.industry, MEDLINE, Warfarin, Vitamin K antagonist, Left ventricular thrombus, Meta-analysis, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

© 2020 Elsevier Inc. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1016/j.amjcard.2020.12.014

Published
2021
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97. Cation disorder and the charge ordering transition temperature in La1/3(Sr1-xCax)2/3FeO3−δ investigated by mechanical spectroscopy.

Author

Wei, D., Ying, X. N., and Lu, X. M.

Subjects
*ORDER-disorder transitions, *TRANSITION temperature, *CALCIUM ions, *SPECTROMETRY, *CATIONS, *PEROVSKITE
Abstract

The lattice effect on the charge ordering in La1/3Sr2/3FeO3−δ is addressed by calcium ion substitution. Cation disorder effect due to size differences between A-site La3+, Sr2+, and Ca2+ has been found in La1/3(Sr1-xCax)2/3FeO3−δ perovskites. Below room temperature, a charge ordering transition has been detected by temperature dependent resistivity, differential scanning calorimeter, and mechanical spectroscopy. The charge ordering transition temperature TC shows a clear dependence on the variance of the A-site cation radius distribution. This result shows an important role of local lattice distortions on the charge ordering transition. As a comparison, octahedral titling transitions above room temperature were identified by mechanical spectroscopy, and the tilting transition temperatures are sensitive to the average cation radius. Finally, the implication of the cation disorder effect is discussed by a comparison of the case in manganates. [ABSTRACT FROM AUTHOR]

Published
2023
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98. Analysis of print news media framing of ketamine treatment in the United States and Canada from 2000 to 2015.

Author

Melvyn W B Zhang, Ying X Hong, Syeda F Husain, Keith M Harris, and Roger C M Ho

Subjects
Medicine, Science
Abstract

OBJECTIVES:There are multifaceted views on the use of ketamine, a potentially addictive substance, to treat mental health problems. The past 15 years have seen growing media coverage of ketamine for medical and other purposes. This study examined the print news media coverage of medical and other uses of ketamine in North America to determine orientations and trends over time. METHODS:Print newspaper coverage of ketamine from 2000 to 2015 was reviewed, resulting in 43 print news articles from 28 North American newspapers. A 55-item structured coding instrument was applied to assess news reports of ketamine. Items captured negative and positive aspects, therapeutic use of ketamine, and adverse side effects. Chi-squares tested for changes in trends over time. RESULTS:In the 15-year reviewed period, the three most frequent themes related to ketamine were: abuse (68.2%), legal status (34.1%), and clinical use in anesthesia (31.8%). There was significant change in trends during two periods (2000-2007 and 2008-2015). In 2008-2015, print news media articles were significantly more likely to encourage clinical use of ketamine to treat depression (p = 0.002), to treat treatment resistant depression (p = 0.043), and to claim that ketamine is more effective than conventional antidepressants (p = 0.043). CONCLUSIONS:Our review found consistent positive changes in the portrayals of ketamine by the print news media as a therapeutic antidepressant that mirror the recent scientific publications. These changes in news media reporting might influence the popularity of ketamine use to treat clinical depression. Guidance is required for journalists on objective reporting of medical research findings, including limitations of current research evidence and potential risks of ketamine.

Published
2017
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99. Assessment and Mitigation of Bleeding Risk in Atrial Fibrillation and Venous Thromboembolism: Executive Summary of a European and Asia-Pacific Expert Consensus Paper

Author

Gorog, Diana A., additional, Gue, Ying X., additional, Chao, Tze-Fan, additional, Fauchier, Laurent, additional, Ferreiro, Jose Luis, additional, Huber, Kurt, additional, Konstantinidis, Stavros V., additional, Lane, Deirdre A., additional, Marin, Francisco, additional, Oldgren, Jonas, additional, Potpara, Tatjana, additional, Roldan, Vanessa, additional, Rubboli, Andrea, additional, Sibbing, Dirk, additional, Tse, Hung-Fat, additional, Vilahur, Gemma, additional, and Lip, Gregory Y. H., additional

Published
2022
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