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Research has suggested that children who speak African American English (AAE) have difficulty using features produced in Mainstream American English (MAE) but not AAE, to comprehend sentences in MAE. However, past studies mainly examined dialect features, such as verbal -s, that are produced as final consonants with shorter durations when produced in conversation which impacts their phonetic saliency. Therefore, it is unclear if previous results are due to the phonetic saliency of the feature or how AAE speakers process MAE dialect features more generally. This study evaluated if there were group differences in how AAE- and MAE-speaking children used the auxiliary verbs was and were, a dialect feature with increased phonetic saliency but produced differently between the dialects, to interpret sentences in MAE. Participants aged 6, 5–10, and 0 years, who spoke MAE or AAE, completed the DELV-ST, a vocabulary measure (PVT), and a sentence comprehension task. In the sentence comprehension task, participants heard sentences in MAE that had either unambiguous or ambiguous subjects. Sentences with ambiguous subjects were used to evaluate group differences in sentence comprehension. AAE-speaking children were less likely than MAE-speaking children to use the auxiliary verbs was and were to interpret sentences in MAE. Furthermore, dialect density was predictive of Black participant’s sensitivity to the auxiliary verb. This finding is consistent with how the auxiliary verb is produced between the two dialects: was is used to mark both singular and plural subjects in AAE, while MAE uses was for singular and were for plural subjects. This study demonstrated that even when the dialect feature is more phonetically salient, differences between how verb morphology is produced in AAE and MAE impact how AAE-speaking children comprehend MAE sentences.

Socioeconomic status (SES) differences in language development are ubiquitous, but existing research has yet to wrestle with how language gaps reflect ( a) differences in relevant concepts for communication, ( b) comprehension strategies to access meanings, and ( c) production practices that express social identity. In child-directed input, parents use verbs to describe similar concepts across SES, and the largest gaps emerge when frequent meanings are being conveyed. During comprehension, children acquire infrequent aspects of grammar across SES but differ in context-specific strategies for interpreting likely meanings. In production, children are sensitive to sociolinguistic implications and adopt context-specific strategies to signal social identity. This suggests that language is a flexible medium for communicating thoughts and that SES effects signal latent differences in meanings and identities across social classes. Whether language gaps contribute to achievement gaps may depend on the extent to which learning and communication draw on these meanings and value these identities.

With the rapid development of e-commerce in China and the global pandemic of COVID-19, more and more sales personnel and brands have abandoned the physical retail industry and started investing in e-commerce. The consumer culture of livestream e-commerce is becoming popular in China. However, a report from Southern Finance Omnimedia Corp of China pointed out that among China's top 1,000 livestream sellers, the top 20 sellers have contributed to nearly half of the gross merchandise volume (GMV), using three major Chinese streaming platforms: Taobao, Douyin, and Kuaishou. Moreover, a novice in livestream e-commerce knows less about the important impact factors of the realm. Akin to the adage, “well aware is well prepared,” knowing more about the influencing factors of livestream e-commerce more will be the chances to promote the commercial value. A benchmark research is needed to systematically trace out the most important and influencing factors and to make possible the rising of selling with less effort, hence this study. The research intends to sort out the relevant influencing factors that affect consumers’ shopping motivation in livestream e-commerce by reviewing previous related literature. Then, through the Delphi method, eight experts constructed the 14 main influencing factors that affect consumers’ shopping motivation in livestream e-commerce. Through DEMATEL-ANP, we can not only find the key factors but also sort out the causal relationship between the main key factors, forming a preliminary evaluation model of the commercial value of livestream sellers. The importance-performance analysis (IPA) of these impact factors found that “seller popularity” is the most critical factor affecting consumers’ shopping motivation. At the same time, product discounts, product quality, and the attractiveness of the sellers are being included in effects by the “seller popularity.” The investigation followed in this study revealed that characteristics of the livestream seller are one of the most influencing factor achieving a total weight of 0.3020, whereas the streaming platform is the least influencing factor (total weight is 0.1333). The assessment made the study explore the sustainability of livestream e-commerce in China, and the proposed evaluation model can be used for the preliminary business value evaluation of people engaged in livestream sellers and related industries.

A Rh(III)-catalyzed cascade C-H activation and cyclization of 2-aryl benzimidazoles with maleimides for the synthesis of benzimidazole-fused isoquinolines and benzimidazole-spiro isoindoles is reported. Switchable selectivity towards the formation of these two distinct products can be achieved using unsubstituted and substituted benzimidazoles at the

BACKGROUND Type 1 diabetes (T1D) is a severe and prevalent metabolic disease. Due to its high heredity, an increasing number of genome-wide association studies have been performed, most of which were from hospital-based case-control studies with a relatively small sample size. The association of single nucleotide polymorphisms (SNPs) and T1D has been less studied and is less understood in natural cohorts. AIM To investigate the significant variants of T1D, which could be potential biomarkers for T1D prediction or even therapy. METHODS A genome-wide association study (GWAS) of adult T1D was performed in a nested case-control study (785 cases vs 804 controls) from a larger 5-year cohort study in Suzhou, China. Potential harmful or protective SNPs were evaluated for T1D. Subsequent expression and splicing quantitative trait loci (eQTL and sQTL) analyses were carried out to identify target genes modulated by these SNPs. RESULTS A harmful SNP for T1D, rs3117017 [odds ratio (OR) = 3.202, 95% confidence interval (CI): 2.296-4.466, P = 9.33 × 10-4] and three protective SNPs rs55846421 (0.113, 0.081-0.156, 1.76 × 10-9), rs75836320 (0.283, 0.205-0.392, 1.07 × 10-4), rs362071 (0.568, 0.495-0.651, 1.66 × 10-4) were identified. Twenty-two genes were further identified as potential candidates for T1D onset. CONCLUSION We identified a potential genetic basis of T1D, both protective and harmful, using a GWAS in a larger nested case-control study of a Chinese population.

Hypoxia is a key characteristic of the breast cancer microenvironment that promotes expression of the transcriptional activator hypoxia-inducible factor 1 (HIF-1) and is associated with poor patient outcome. HIF-1 increases the expression or activity of stem cell pluripotency factors, which control breast cancer stem cell (BCSC) specification and are required for cancer metastasis. Here, we identify nuclear prelamin A recognition factor ( NARF ) as a hypoxia-inducible, HIF-1 target gene in human breast cancer cells. NARF functions as an essential coactivator by recruiting the histone demethylase KDM6A to OCT4 bound to genes encoding the pluripotency factors NANOG, KLF4, and SOX2, leading to demethylation of histone H3 trimethylated at lysine-27 (H3K27me3), thereby increasing the expression of NANOG, KLF4, and SOX2, which, together with OCT4, mediate BCSC specification. Knockdown of NARF significantly decreased the BCSC population in vitro and markedly impaired tumor initiation capacity and lung metastasis in orthotopic mouse models.

As members of the editorial team at Language Acquisition, we read Kidd and Garcia’s target article with enthusiasm. In our commentary, we outline some specific ideas for how journals can help to alleviate the issues raised by Kidd and Garcia, some of which are in progress or in place at Language Acquisition, and some of which we hope to undertake alongside other journals in the field. We focus on concrete steps, acknowledging that systemic changes, too, will be required to ensure that our science reflects the diversity of languages learned.

Polyester/cotton (T/C) blend fabrics are highly flammable due to the particular “scaffolding effect”. In this work, an intumescent flame retardant (IFR) agent containing P, N, and B was designed and synthesized using bio-based phytic acid, pentaerythritol, boric acid, and urea. The IFR compounds were deposited onto a T/C blend fabric by the surface-coating route. The chemical structure of IFR agent and its potential cross-linking reactions with T/C fibers were characterized. The morphology, thermal stability, heat-release ability, flame retardancy, and mechanism of coated T/C blend fabrics were explored. The self-extinguishing action was observed for the coated T/C blend fabric with a weight gain of 13.7%; the limiting oxygen index (LOI) value increased to 27.1% versus 16.9% for a pristine one. Furthermore, the intumescent flame retardant (IFR) coating imparted T/C blend fabrics with high thermal stability and significantly suppressed heat release by nearly 50%. The char residue analyses on morphology and element content confirmed the intumescent FR action for coated T/C blend fabrics. The prepared IFR coating has great potential to serve as an eco-friendly approach for improving the flame retardancy of T/C blend textiles.

This is a case report of a uterine cancer with the International Federation of Gynecology and Obstetrics staging 3c2 with the initial clinical presentation of postmenopausal vaginal bleeding in August 2015. Endometrium biopsy showed invasive nests of poorly differentiated grade 3 endometrioid adenocarcinoma. The patient received robotic surgery including total hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic lymph node dissection, para-aortic lymph node dissection, and washing cytology. The final pathology showed an endometrioid carcinoma with myometrium invasion up to 85% and para-aortic and pelvic lymph nodes invasion. The patient received six courses of adjuvant chemotherapy (paclitaxel and carboplatin) with concurrent chemoradiotherapy after the surgery. Later, immunotherapy with Picibanil (OK-432) and interleukin-2 (IL-2) was given, and cancer did not recur for 34 months until tumor recurrence at the liver dome and bilateral lung was noted by positron-emission tomography scan in July 2018. The patient received laparoscopic surgery for intra-abdominal tumor excision in December 2018, and the tumor found extended to the right diaphragm, liver surface, omentum, bilateral flank to pelvic peritoneum, Douglas pouch, and upper rectum. We continued the immunotherapy with OK-432, IL-2, Aldara cream (imiquimod), and later on, virotherapy (human papillomavirus vaccine). The immune risk profiles showed T–cells' proliferation and alteration of the Th1/Th2 activation after immunotherapy and virotherapy. Proctectomy with colon-anal anastomosis and cytoreduction surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) (doxorubicin and paclitaxel) was performed in January 2019. After the surgery, the patient received chemotherapy (topotecan, paclitaxel, lipodox, and carboplatin) and continued the immunotherapy. The immune risk profiles showed CD4, CD4/CD8 increase after HIPEC and immunotherapy. The patient continued the therapy until May 2020.