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245 results on '"Ye, Caiyong"'

66. Requirement of Bccipfor the Regeneration of Intestinal Progenitors

Author

Lu, Huimei, Ye, Caiyong, Liu, Jingmei, Rabson, Arnold B., Verzi, Michael, De, Subhajyoti, and Shen, Zhiyuan

Abstract

BCCIP was originally identified as a BRCA2 and CDKN1A/p21 interaction protein. Although a partial loss of BCCIPfunction is sufficient to trigger genomic instability and tumorigenesis, complete deletion of BCCIPis lethal to cells. Using Rosa26-CreERT2 mouse models, we found that induced Bccipdeletion in adult mice caused an acute intestinal epithelial denudation that cannot be relieved by co-deletion of Trp53. The critical role of Bccipin intestine epithelial renewal was verified with a Villin-CreERT2 mouse model. The epithelium degeneration was associated with a rapid loss of the proliferative capability of the crypt progenitor cells in vivo, lack of crypt base columnar stem cell markers, and a failure of in vitrocrypt organoid growth. RNA-Seq analysis of freshly isolated intestinal crypt cells showed that Bccipdeletion caused an overwhelming down-regulation of genes involved in mitotic cell division but an up-regulation of genes involved in apoptosis and stress response to microbiomes. Our data not only indicate that intestinal epithelium is the most sensitive tissue to whole-body deletion of Bccipbut also point to Bccipas a novel and critical factor for the proliferation of the intestinal progenitors. These findings have significant implications for understanding why a hypomorphic loss of BCCIP functions is more relevant to tumorigenesis.

Published
2021
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67. Cell cycle suspension: A novel process lurking in G2 arrest

Author

He, Jinpeng, Li, Junhong, Ye, Caiyong, Zhou, Libin, Zhu, Jiayun, Wang, Jiayun, Mizota, Atsushi, Furusawa, Yoshiya, and Zhou, Guangming

Abstract

Cell cycle checkpoint is a self-protective mechanism for cells to monitor genome integrity and ensure the high-fidelity transmission of genetic information to daughter cells. Insufficient function of cell cycle checkpoints has been demonstrated to partially account for tumor initiation, promotion and progression. In the ten melanoma cell lines that we tested in preliminary experiments, two human uveal melanoma cell lines, 92-1 and OCM-1, were found to be significantly different in terms of radiosensitivity but similar in DNA repair ability. Evident G2 arrest was induced in both cell types and the maximum was reached at 16 h after irradiation regardless of X-rays or high-LET carbon beams. OCM-1 cells overrode the G2 arrest and reentered the cell cycle right after reaching the maximum, whereas 92-1 could not. Upon 10 Gy of radiation, the cell cycle of 92-1 was suspended and remained unchanged for up to 5 d. The cell cycle suspension is a unique process lurking in G2 arrest and related to cellular radiosensitivity. Its induction is dose-dependent and there is a dose threshold for it. The degradation of Cyclin B1 has been found related to the cell cycle suspension though, the mechanism of cell cycle suspension is still under investigation. Basing on our knowledge, this is the first report on cell cycle suspension and we present here a de novo mechanism to cellular radiosensitivity. Further clarification of the mechanism underlying cell cycle suspension is believed to be of significance in tumor radiosensitization or even direct tumor control.

Published
2011

81. A Novel Hybrid Excited Doubly Salient Machine With Asymmetric Stator Poles.

Author

He, Mingjie, Xu, Wei, Zhu, Jianguo, Ning, Lei, Du, Guanghui, and Ye, Caiyong

Subjects
PERMANENT magnet generators, AIR gap flux, MAGNETIC circuits, MACHINING, ACTINIC flux, STATORS, POLISH people
Abstract

A novel hybrid excited asymmetric stator pole doubly salient machine (HEASPDSM) is proposed in this paper. The new topologies and operational principle are first investigated by using a simplified equivalent magnetic circuit model. The harmonic components of air-gap flux density are then analyzed. The influence of key structural parameters of the proposed machine on the flux regulation ability and torque is studied. A full comparison on main electromagnetic performance indexes of the proposed 12/7 (stator/rotor poles) HEASPDSPM and several traditional doubly salient machines is presented. A prototype is fabricated and tested to validate the theoretical analysis. The results well demonstrate that the HEASPDSPM possesses various merits, such as strong flux regulation capability, high torque density, low cogging torque, and low torque ripple. [ABSTRACT FROM AUTHOR]

Published
2019
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86. Analysis of homopolar inductor alternator for high reliability high power density applications

Author

Lou Zhenxiu, Ye Caiyong, Ren Zhangao, and Yu Kexun

Subjects
Alternator (automotive), Engineering, Homopolar motor, business.industry, Rotor (electric), Electrical engineering, Compensated pulsed alternator, Inductor, law.invention, Reliability (semiconductor), Electromagnetic coil, law, Waveform, business
Abstract

Based on the analysis of the performance requirements for movable power station, homopolar inductor alternator is chosen in pursuit of high reliability and high power density. A new method called one-side analysis for investigation into homopolar inductor alternator is presented firstly in this paper. The influence of varied shapes and dimensions of rotor slot on waveform of no-load airgap flux density is analyzed. Some design characteristics of homopolar inductor alternator are discussed.

Published
2009

97. Quantitative proteomic analysis for radiation-induced cell cycle suspension in 92-1 melanoma cell line

Author

Wang, Fengling, primary, Bing, Zhitong, additional, Zhang, Yanan, additional, Ao, Bin, additional, Zhang, Sheng, additional, Ye, Caiyong, additional, He, Jinpeng, additional, Ding, Nan, additional, Ye, Wenling, additional, Xiong, Jie, additional, Sun, Jintu, additional, Furusawa, Yoshiya, additional, Zhou, Guangming, additional, and Yang, Lei, additional

Published
2013
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