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51. Contents Vol. 101, 2012

Author

Jung-Hwan Choi, Frans J. Walther, Ertan Mayatepek, Satz Mengensatzproduktion, Ee-Kyung Kim, Y.S. Prakash, Aaron Hamvas, Anders Bäckman, Tim Schindler, M. Moll, E.J. Molloy, Veronika Tosse, D. Noone, Thierry Lacaze-Masmonteil, Sandra Heck, Ola Didrik Saugstad, Druck Reinhardt Druck Basel, Irene T.M. Lindenburg, F.J. Walther, Vivianne E.H.J. Smits-Wintjens, Thomas Hoehn, S. Minocchieri, E.E.M. Mulder, Graeme R. Polglase, Katherine J Lee, Joerg Fuchs, Rhonda J. Rosychuk, J. Jane Pillow, Kei Lui, Frank Pillekamp, Erik W. van Zwet, E. Kieran, Hemmen Sabir, Neama Meriki, Dick Oepkes, John Smyth, Joerg Arand, Ann Hudson-Mason, Peter M. MacFarlane, Berit Hadzik, Michael O’Reilly, Guido Seitz, Rangmar Goelz, Carmen Eicher, Yong Song, Embjørg J. Wollen, Enrico Lopriore, Han Suk Kim, Mirjam E.A. Rath, Maria Björkqvist, Jens Schollin, M. Rijken, Rod W. Hunt, Yngve Sejersted, E. Lopriore, Richard J. Martin, Andreas Ohlin, Beyong Il Kim, Peter A. Dargaville, Andrew Davidson, Christian F. Poets, Chang Won Choi, Andrea Bevot, Brent Reyburn, Gabrielle C. Musk, Alec W. Welsh, Pablo Verde, A.B. te Pas, Rønnaug Solberg, Hyun Ju Lee, Magnar Bjørås, Uwe Ewald, and Monika Olischar

Subjects
Pediatrics, medicine.medical_specialty, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, Medicine, business, Developmental Biology
Published
2012

52. 27th International Workshop on Surfactant Replacement, Lisbon, June 1–2, 2012

Author

M. Rijken, Embjørg J. Wollen, E. Lopriore, Veronika Tosse, F.J. Walther, Irene T.M. Lindenburg, Katherine J Lee, Han Suk Kim, Rod W. Hunt, Richard J. Martin, Brent Reyburn, Ola Didrik Saugstad, Hemmen Sabir, Graeme R. Polglase, S. Minocchieri, Berit Hadzik, Peter M. MacFarlane, Alec W. Welsh, Guido Seitz, Frans J. Walther, Carmen Eicher, Andrea Bevot, Joerg Arand, Pablo Verde, Neama Meriki, Mirjam E.A. Rath, Druck Reinhardt Druck Basel, A.B. te Pas, Rønnaug Solberg, Dick Oepkes, Michael O’Reilly, Ee-Kyung Kim, E.J. Molloy, D. Noone, Sandra Heck, Thierry Lacaze-Masmonteil, M. Moll, E.E.M. Mulder, Jung-Hwan Choi, Hyun Ju Lee, Beyong Il Kim, Vivianne E.H.J. Smits-Wintjens, E. Kieran, Magnar Bjørås, Peter A. Dargaville, Thomas Hoehn, Christian F. Poets, Frank Pillekamp, John Smyth, Andrew Davidson, Kei Lui, Maria Björkqvist, Anders Bäckman, Chang Won Choi, Jens Schollin, Satz Mengensatzproduktion, Y.S. Prakash, Aaron Hamvas, Yngve Sejersted, Enrico Lopriore, Rhonda J. Rosychuk, Uwe Ewald, Ann Hudson-Mason, Monika Olischar, Gabrielle C. Musk, J. Jane Pillow, Yong Song, Erik W. van Zwet, Joerg Fuchs, Tim Schindler, Rangmar Goelz, Ertan Mayatepek, and Andreas Ohlin

Subjects
medicine.medical_specialty, Pediatrics, business.industry, General surgery, Pediatrics, Perinatology and Child Health, Medicine, Surfactant replacement, business, Developmental Biology
Published
2012

53. Effect of CPAP in a Mouse Model of Hyperoxic Neonatal Lung Injury

Author

Reyburn, Brent, Fiore, Juliann M. Di, Raffay, Thomas, Martin, Richard J., Y.S., Prakash, Jafri, Anjum, and MacFarlane, Peter M.

Subjects
Male, Continuous Positive Airway Pressure, Macrophages, Lung Injury, Hyperoxia, Article, Respiratory Function Tests, Mice, Inbred C57BL, Oxygen, Disease Models, Animal, Mice, Animals, Newborn, Animals, Female, Bronchopulmonary Dysplasia
Abstract

Continuous positive airway pressure (CPAP) and supplemental oxygen have become the mainstay of neonatal respiratory support in preterm infants. Although oxygen therapy is associated with respiratory morbidities including bronchopulmonary dysplasia (BPD), the long-term effects of CPAP on lung function are largely unknown. We used a hyperoxia-induced mouse model of BPD to explore the effects of daily CPAP in the first week of life on later respiratory system mechanics.We wanted to test the hypothesis that daily CPAP in a newborn-mouse model of BPD improves longer-term respiratory mechanics.Mouse pups from C57BL/6 pregnant dams were exposed to room air (RA) or hyperoxia (50% O2, 24 h/day) for the first postnatal week with or without exposure to daily CPAP (6 cm H2O, 3 h/day). Respiratory system resistance (Rrs) and compliance (Crs) were measured following a subsequent 2-week period of RA recovery. Additional measurements included radial alveolar and macrophage counts.Mice exposed to hyperoxia had significantly elevated Rrs, decreased Crs, reduced alveolarization and increased macrophage counts at 3 weeks when compared to RA-treated mice. Daily CPAP treatment significantly improved Rrs, Crs and alveolarization and decreased lung macrophage infiltration in the hyperoxia-exposed pups.We have demonstrated that daily CPAP had a longer-term benefit on baseline respiratory system mechanics in a neonatal mouse model of BPD. We speculate that this beneficial effect of CPAP was the consequence of a decrease in the inflammatory response and resultant alveolar injury associated with hyperoxic lung injury in newborns.

Published
2015

54. Aberrant right common carotid artery: a diagnostic challenge on transesophageal echocardiography

Author

Y.S. Prakash and Joseph F. Malouf

Subjects
Male, medicine.medical_specialty, medicine.diagnostic_test, Carotid Artery, Common, business.industry, Coronary Vessel Anomalies, Aortic arch anomalies, Magnetic resonance angiography, Imaging, Three-Dimensional, VASCULAR ABNORMALITY, Right Common Carotid Artery, Internal medicine, cardiovascular system, medicine, Cardiology, Humans, Radiology, Nuclear Medicine and imaging, Radiology, Cardiology and Cardiovascular Medicine, business, human activities, Echocardiography, Transesophageal, Cardiac imaging, Aged
Abstract

Aortic arch anomalies are rare, but when present the aberrant vessels may simulate significant vascular abnormality on transesophageal echocardiography (TEE). We report a case of aberrant right common carotid artery. Diagnosis was first suspected on TEE using multiplane and off-axis imaging and subsequently confirmed on magnetic resonance angiography.

Published
2004

55. Surfactant Replacement: The Search for a Softer Touch

Author

Hyun Ju Lee, Ee-Kyung Kim, Magnar Bjørås, E.J. Molloy, Ola Didrik Saugstad, Frans J. Walther, Veronika Tosse, Irene T.M. Lindenburg, Ann Hudson-Mason, D. Noone, M. Moll, E.E.M. Mulder, Joerg Fuchs, Jung-Hwan Choi, Uwe Ewald, Monika Olischar, Joerg Arand, J. Jane Pillow, Vivianne E.H.J. Smits-Wintjens, Brent Reyburn, F.J. Walther, Rønnaug Solberg, Mirjam E.A. Rath, Satz Mengensatzproduktion, Guido Seitz, Dick Oepkes, Rod W. Hunt, Tim Schindler, Richard J. Martin, John Smyth, Thomas Hoehn, Alec W. Welsh, Han Suk Kim, Kei Lui, Graeme R. Polglase, Katherine J Lee, Peter M. MacFarlane, Hemmen Sabir, Gabrielle C. Musk, Frank Pillekamp, Pablo Verde, Yngve Sejersted, Carmen Eicher, Erik W. van Zwet, E. Kieran, A.B. te Pas, Michael O’Reilly, Yong Song, S. Minocchieri, Anders Bäckman, Sandra Heck, Andreas Ohlin, Rhonda J. Rosychuk, Y.S. Prakash, Aaron Hamvas, Ertan Mayatepek, Neama Meriki, Berit Hadzik, M. Rijken, Thierry Lacaze-Masmonteil, E. Lopriore, Enrico Lopriore, Maria Björkqvist, Jens Schollin, Rangmar Goelz, Beyong Il Kim, Peter A. Dargaville, Andrew Davidson, Embjørg J. Wollen, Druck Reinhardt Druck Basel, Andrea Bevot, Christian F. Poets, and Chang Won Choi

Subjects
business.industry, Pediatrics, Perinatology and Child Health, Medicine, Surfactant replacement, Nanotechnology, business, Developmental Biology
Published
2012

56. Relative efficacy of organic manures on rice production in lateritic soil

Author

Y.S. Prakash, Pratap Bhanu Singh Bhadoria, S. Kar, and Amitava Rakshit

Subjects
Farmyard manure, Oryza sativa, Relative efficacy, Field experiment, food and beverages, Soil Science, engineering.material, Straw, Micronutrient, Pollution, Agronomy, engineering, Environmental science, Poaceae, Vermicompost, Agronomy and Crop Science
Abstract

Field experiments were carried out to evaluate the relative efficacy of organic manures in improving the productivity and pest tolerance of rice growing in a lateritic soil. The effects of three commercial manures: processed city waste (PCW), vermicompost (VC) and oil cake pellets (OCP), were assessed in comparison to farmyard manure (FYM) and inorganic fertilizer all at the same total N applied. Of the organic manures tested, FYM produced the maximum straw and grain yields. Differences in yield among the organic manure treatments were mainly attributed to variation in the amounts of available N, P, K and micronutrients. Effect of manures on soil physical condition was not studied. The uptake of N, P and K by rice plants with FYM was significantly greater than all other commercial manures and inorganic fertilizer. The tolerance of rice plants to attack by pathogens and pests, measured in terms of grain yield was highest in the treatment with FYM. Among the commercial manures PCW showed the greatest promise and emerged as a potential alternative to FYM.

Published
2003

57. The 'Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO)' Study : Background, Aims, and Study Protocol

Author

Erik W. van Zwet, Sandra Heck, E. Kieran, F.J. Walther, Gabrielle C. Musk, Tim Schindler, Han Suk Kim, Hyun Ju Lee, Michael O’Reilly, Rangmar Goelz, Irene T.M. Lindenburg, Magnar Bjørås, E.E.M. Mulder, Rhonda J. Rosychuk, Ola Didrik Saugstad, Andreas Ohlin, Vivianne E.H.J. Smits-Wintjens, Joerg Fuchs, Frans J. Walther, Ertan Mayatepek, Rønnaug Solberg, M. Moll, Dick Oepkes, Frank Pillekamp, Yong Song, Anders Bäckman, Ee-Kyung Kim, Satz Mengensatzproduktion, E.J. Molloy, Carmen Eicher, Jung-Hwan Choi, Yngve Sejersted, Thierry Lacaze-Masmonteil, Uwe Ewald, Monika Olischar, Y.S. Prakash, Aaron Hamvas, Mirjam E.A. Rath, A.B. te Pas, D. Noone, Guido Seitz, Thomas Hoehn, Berit Hadzik, Kei Lui, S. Minocchieri, Katherine J Lee, Rod W. Hunt, Richard J. Martin, Veronika Tosse, Neama Meriki, Brent Reyburn, Joerg Arand, Alec W. Welsh, Graeme R. Polglase, Pablo Verde, John Smyth, Peter M. MacFarlane, M. Rijken, E. Lopriore, Druck Reinhardt Druck Basel, Beyong Il Kim, Peter A. Dargaville, Andrew Davidson, J. Jane Pillow, Enrico Lopriore, Maria Björkqvist, Jens Schollin, Embjørg J. Wollen, Ann Hudson-Mason, Hemmen Sabir, Christian F. Poets, Chang Won Choi, Andrea Bevot, Stein, Anja (Beitragende*r), Keller, Matthias (Beitragende*r), and Hüning, Britta Maria (Beitragende*r)

Subjects
Protocol (science), Pediatrics, medicine.medical_specialty, business.industry, MEDLINE, Medizin, medicine.disease, Anemia of prematurity, law.invention, Very preterm, Low birth weight, Randomized controlled trial, law, Pediatrics, Perinatology and Child Health, medicine, medicine.symptom, business, Intensive care medicine, Neurocognitive, Developmental Biology
Abstract

Background: Infants with extremely low birth weight uniformly develop anemia of prematurity and frequently require red blood cell transfusions (RBCTs). Although RBCT is widely practiced, the indications remain controversial in the absence of conclusive data on the long-term effects of RBCT. Objectives: To summarize the current equipoise and to outline the study protocol of the ‘Effects of Transfusion Thresholds on Neurocognitive Outcome of extremely low birth-weight infants (ETTNO)’ study. Methods: Review of the literature and design of a large pragmatic randomized controlled trial of restrictive versus liberal RBCT guidelines enrolling 920 infants with birth weights of 400–999 g with long-term neurodevelopmental follow-up. Results and Conclusions: The results of ETTNO will provide definite data about the efficacy and safety of restrictive versus liberal RBCT guidelines in very preterm infants.

Published
2012

58. Role of arginase in impairing relaxation of lung parenchyma of hyperoxia-exposed neonatal rats

Author

Nuzhat K.M. Ali, Syed I.A. Zaidi, Richard J. Martin, Anjum Jafri, Ramadan B Sopi, and Y.S. Prakash

Subjects
medicine.medical_specialty, Muscle Relaxation, Hyperoxia, Arginine, Nitric Oxide, Nitric oxide, Rats, Sprague-Dawley, chemistry.chemical_compound, Internal medicine, medicine, Animals, Lung, Original Paper, Arginase, business.industry, Muscle, Smooth, respiratory system, Bethanechol, Electric Stimulation, respiratory tract diseases, Blockade, Rats, Up-Regulation, Endocrinology, Muscle relaxation, medicine.anatomical_structure, chemistry, Animals, Newborn, Parasympathomimetics, Pediatrics, Perinatology and Child Health, Room air distribution, Respiratory epithelium, medicine.symptom, business, Developmental Biology, Signal Transduction
Abstract

Background: Prolonged exposure of immature lungs to hyperoxia contributes to neonatal lung injury and airway hyperreactivity. We have previously demonstrated that neonatal exposure of rat pups to ≧95% O2 impairs airway relaxation due to disruption of nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling. Objective: We now hypothesize that these impaired relaxation responses are secondary to hyperoxia-induced upregulation of arginase, which competes with NO synthase for L-arginine. Methods: Rat pups were exposed to moderate neonatal hyperoxia (50% O2) or room air for 7 days from birth. In additional hyperoxic and room air groups, exogenous L-arginine (300 mg/kg/day i.p.) or arginase inhibitor (Nω-hydroxy-nor-arginine, 30 mg/kg/day i.p.) were administered daily. After 7 days, animals were anesthetized and sacrificed either for preparation of lung parenchymal strips or lung perfusion. Results: In response to electrical field stimulation (EFS), bethanechol-preconstricted lung parenchymal strips from hyperoxic pups exhibited significantly reduced relaxation compared to room air controls. Supplementation of L-arginine or arginase blockade restored hyperoxia-induced impairment of relaxation. Expression of arginase I in airway epithelium was increased in response to hyperoxia but reduced by arginase blockade. Arginase activity was also significantly increased in hyperoxic lungs as compared to room air controls and reduced following arginase blockade. EFS-induced production of NO was decreased in hyperoxia-exposed airway smooth muscle and restored by arginase blockade. Conclusion: These data suggest that NO-cGMP signaling is disrupted in neonatal rat pups exposed to even moderate hyperoxia due to increased arginase activity and consequent decreased bioavailability of the substrate L-arginine. We speculate that supplementation of arginine and/or inhibition of arginase may be a useful therapeutic tool to prevent or treat neonatal lung injury.

Published
2010

60. Contributors

Author

S.R. Adams, R. Aikens, S. Antić, B.J. Bacskai, M.N. Badminton, T.C. Bakker Schut, I. Bar-Am, E. Blancaflor, F. Bobanović, N. Bodsworth, S. Bolsover, M.D. Bootman, D.N. Bowser, H.A. Bruining, H.P.J. Buschman, A.K. Campbell, P.J. Caspers, B. Chance, S.H. Cody, L.B. Cohen, J.M.C.C. Coremans, G.C. Cox, A.A. Culbert, R. DeBasio, A.W. de Feijter, J. Dempster, P.N. Dubbin, Z. Dubinsky, C.X. Falk, K. Florine-Casteel, N. Foote, M.D. Fricker, T.W.J. Gadella, S. Gilroy, E. Gratton, A.M. Gurney, R. Haggart, K. Hahn, R.P. Haugland, B. Herman, D. Hoekstra, M.A. Horton, J. Hoyland, A. Ichihara, H. Ishida, I.D. Johnson, H.E. Jones, S.R. Kain, M.S. Kannan, F.H. Kasten, S. Katz, J.M. Kendall, H. Knight, M.R. Knight, J.W. Kok, J. Kolega, I. Kurtz, J.J. Lemasters, P. Lipp, D.H. Llewellyn, L. Loew, A. Lyons, C. Mackay, Z. Malik, W.T. Mason, B.R. Masters, T.J. McCann, T.J. Mitchison, J. Montibeller, J. Myers, W. O'Brien, C. Plieth, J.S. Ploem, P. Post, Y.S. Prakash, G.J. Puppels, T.J. Römer, C. Rothmann, G.A. Rutter, G.B. Sala-Newby, K.E. Sawin, G. Shankar, C.J.R. Sheppard, M. Shimizu, S.L. Shorte, G.C. Sieck, E.R. Simons, V. Singer, G. Skews, P.T.C. So, B. Somasundaram, T. Tanaami, J.M. Tavaré, S.S. Taylor, K.M. Taylor, D.L. Taylor, J.A. Theriot, P. Tomkins, J.E. Trosko, R.Y. Tsien, M.H. Wade, N.S. White, D.A. Williams, R. Wolthuis, J.-y. Wu, K.-P. Yip, D. Zečević, and A.V. Zelenin

Published
1999

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