Search

The electrocaloric (EC) effect in dielectrics has shown great potential in the next-generation solid-state refrigeration; however, most dielectrics cannot satisfy the requirement for refrigeration at various temperatures. How to control large EC response to various temperatures is a critical problem for practical cooling applications. In this work, based on entropy analysis, a nonlinear thermodynamic approach considering mechanical loading has been generalized to demonstrate mechanical control of EC response in epitaxial ferroelectric BaxSr1−xTiO3 (BST) thin films. The effects of chemical composition x, in-plane misfit strain u m , and out-of-plane external uniaxial stress σ 3 on the phase diagrams, phase transition temperatures, and EC response of BST thin films have been studied. The results reveal that a large EC temperature change Δ T appears in the vicinity of c-PE and r-aa phase boundaries, because the polarization component P3 becomes zero across both phase boundaries, leading to a large change of order in dipoles. It is found that the phase structures and the transition temperatures are sensitive to misfit strain and stress. Large EC response in BST thin films can be controlled and shifted to various temperatures over a wide temperature range for practical applications. It also indicates that the peak of Δ T can be shifted to higher temperature under in-plane compressive strain u m , while it is shifted to lower temperature under tensile strain u m or compressive stress σ 3 . Furthermore, the optimal combination of misfit strain and stress for the EC temperature change are identified, which further enhances EC response. These insights offer an alternative pathway to control and implement EC refrigeration over a wide range of temperature.

Kinetic-scale magnetic holes (KSMHs) are structures characterized by a significant magnetic depression with a length scale on the order of the proton gyroradius. These structures have been investigated in recent studies in near-Earth space, and found to be closely related to energy conversion and particle acceleration, wave-particle interactions, magnetic reconnection, and turbulence at the kinetic-scale. However, there are still several major issues of the KSMHs that need further study — including (a) the source of these structures (locally generated in near-Earth space, or carried by the solar wind), (b) the environmental conditions leading to their generation, and (c) their spatio-temporal characteristics. In this study, KSMHs in near-Earth space are investigated statistically using data from the Magnetospheric Multiscale mission. Approximately 200,000 events were observed from September 2015 to March 2020. Occurrence rates of such structures in the solar wind, magnetosheath, and magnetotail were obtained. We find that KSMHs occur in the magnetosheath at rates far above their occurrence in the solar wind. This indicates that most of the structures are generated locally in the magnetosheath, rather than advected with the solar wind. Moreover, KSMHs occur in the downstream region of the quasi-parallel shock at rates significantly higher than in the downstream region of the quasi-perpendicular shock, indicating a relationship with the turbulent plasma environment. Close to the magnetopause, we find that the depths of KSMHs decrease as their temporal-scale increases. We also find that the spatial-scales of the KSMHs near the subsolar magnetosheath are smaller than those in the flanks. Furthermore, their global distribution shows a significant dawn-dusk asymmetry (duskside dominating) in the magnetotail.

痉挛性发声障碍（spasmodic dysphonia，SD）是一种由局灶性喉肌张力障碍引起的发声困难，以不规则和非控制性的发声中断为特征性表现，伴有发声费力。有报道其患病率约为1/100 000，中年女性多见，我国男女性发病性别比为1∶10.3，高发年龄段为30~49岁。根据受累肌群和临床特点，SD可分为3个类型，其中内收型（adductor spasmodic dysphonia，AdSD）最常见，约占SD患者的80％，外展型（abductor spasmodic dysphonia，AbSD）和混合型（mixed spasmodic dysphonia，MSD）较少见。目前，对SD的研究主要集中在治疗上，而对病理生理学的探索相对有限，临床诊断也因缺乏标准而具有挑战性，通常需要喉科医师、言语病理师及神经科医师的多学科合作。.

This paper presents a Taipei MRT project as an example to illustrate the process and benefit of using BIM in a deep excavation case. The BIM concepts that are being used in this project include, (1) transforming and integrating soil boring information and soil profiles data into a comprehensive 3D models, (2) establishing 3D BIM for excavation and its strutting system, (3) detecting conflicts between interfaces, such as support and hoist systems, and creating a 4D construction simulation model by integrating construction schedule into the original 3D BIM model, and (4) creating and displaying the structure model, design and construction drawings, and quantity calculation sheets with the support of other compatible software. BIM is expected to bring a more direct and visual display and presentation of information for construction progress, and to make construction control and management simpler and more efficient. The project in the paper could be a reference for other geotechnical design and construction cases.

Some kinds of chronic sialadenitis were recognized during the recent years. They have specific pathogenesis, clinical and histopathologic appearances, and require specific treatment. IgG4-related sialadenitis (IgG4-RS) is one of the immune-mediated diseases, characterized by tumefactive lesions. The incidence of IgG4-RS obviously increased during the past 30 years. The study on the potential relationship between occupational exposure to chemical substances and the incidence of IgG4-RS showed that subjects with occupational exposure to agents known to cause IgG4-RD had an increased risk for IgG4-RS. Surgical excision of involved SMG could not control the disease progression, which is not recommended for treatment of IgG4-RS. The combination of glucocorticoid and steroid-sparing agents is effective for treating IgG4-RS, and restores salivary gland function. Radioiodine induced sialadenitis (RAIS) is one of the common complications of postoperative adjuvant treatment of differentiated thyroid cancer by (131)I. The incidence of the disease is related to radiation dosage. Clinically, the patients suffered from swelling and tenderness in the buccal or submandibular regions, especially during the mealtime. Imaging appearances are similar to those of chronic obstructive sialadenitis. Conservative managements, such as gland massage, sialagogues, are the mainstream methods in the treatment of RAIS. Sialendoscopy is feasible for RAIS, but not as effective as conventional obstructive sialadenitis (COS). Therefore the prevention of RAIS is crucial. Eosinophilic sialodochitis (ES) is a new type of chronic inflammatory disease of the salivary gland related to allergy. It has characteristics of swelling of multiple major salivary glands, strip-like gelatinous plugs discharged from the duct orifice of the gland, elevated level of serum IgE and eosinophils in peripheral blood, infiltration of eosinophils and IgE positive plasma cells in the tissues, allergic history, increased expression of allergy-related cytokines, such as IL-4, IL-5, IL-13, and eotaxin, which suggest allergic reactions as a potential pathogenesis of the disease. The clinical, laboratory, histological, and immunohistochemical characteristics of ES are significantly different from conventional obstructive sialadenitis (COS). Therefore, it is suitable to separate ES from COS. Conservative managements, such as self-maintenance therapy and anti- allergic modality are the choices of treatment for ES. Based on the results of our comprehensive studies a new classification of chronic sialadenitis is suggested.

This study presents impingement cooling from a flat plate by multiple asymmetric jets. Such jets are discharged through blunt-edge inline orifice holes with a thickness-to-diameter ratio of t/Dj = 0.5 and a jet-to-jet spacing of T/Dj = 4.0, at the Reynolds number of 20,000. First, fluidic features are established both in free exit and with impingement, at varying short target spacing (e.g., H/Dj ≤ 4.0). Second, thermal characteristics of the jet impingement are elucidated. Results demonstrate that, due to a skewed incidence of the coolant stream upstream of concave orifice holes, the resulting multiple orifice jets are asymmetric and skewed relative to the orifice axis. These results mimic multiple fluidically inclined jets. However, asymmetric entrainment that takes place causes faster mixing with the surrounding fluid at rest as well as faster decay of momentum. This shows more effective cooling from a flat plate for the relatively short H/Dj range than conventional symmetric orifice and nozzle jets.

Plasma jets are ubiquitous in space. In geospace, jets can be generated by magnetic reconnection. These reconnection jets, typically at fluid scale, brake in the near-Earth region, dissipate their energies, and drive plasma dynamics at kinetic scales, generating field-aligned currents that are crucial to magnetospheric dynamics. Understanding of the cross-scale dynamics is fundamentally important, but observation of coupling among phenomena at various scales is highly challenging. Here we report, using unprecedentedly high-cadence data from NASA's Magnetospheric Multiscale Mission, the first observation of cross-scale dynamics driven by jet braking in geospace. We find that jet braking causes MHD-scale distortion of magnetic field lines and development of an ion-scale jet front that hosts strong Hall electric fields. Parallel electric fields arising from the ion-scale Hall potential generate intense electron-scale field-aligned currents, which drive strong Debye-scale turbulence. Debye-scale waves conversely limit intensity of the field-aligned currents, thereby coupling back to the large-scale dynamics. Our study can help in understanding how energy deposited in large-scale structures is transferred into small-scale structures in space.

2例2型糖尿病患者因周围神经病变静脉应用α-硫辛酸后反复出现晨空腹低血糖，伴高胰岛素血症及胰岛素自身抗体（IAA）阳性而诊断为胰岛素自身免疫综合征（IAS）。予以相应处理后，随访2年8个月，无低血糖，空腹血胰岛素水平逐渐下降接近正常，IAA转阴或弱阳性。2例患者均携带HLA-DRB1*04∶06等位基因，其一级亲属中4人携带此等位基因，均应避免应用含巯基药物以免发生IAS。.

Multidrug-resistant pneumonia is a common cause of hospital-related morbidity and mortality across the world. The high prevalence of multidrug-resistant pneumonia due to resistant gram-negative pathogens has led to a re-introduction of colistin. The adverse events associated with intravenous colistin can be alleviated by administering the drug nasally (i.e., inhalation) or in a combination including both inhalation and intravenous presentations of the drug. A review study compared the impact of these administration methods on clinical, morbidity, and mortality-related outcomes in patients with multiple-drug resistant pneumonia. However, the publication of newer cohort trials, warrants an update of the state of the evidence. To compare the clinical, morbidity, and mortality outcomes in patients with multidrug-resistant pneumonia receiving either intravenous colistin or combined drug presentations (ie, inhaled and intravenous). A systematic search of the academic literature was performed according to the PRISMA guidelines across five databases (Web of Science, EMBASE, CENTRAL, Scopus, and MEDLINE). We conducted a random-effect meta-analysis to compare outcomes such as rate of clinical cure, microbiological eradication, nephrotoxicity, and overall mortality in patients with multidrug-resistant pneumonia receiving either intravenous colistin, inhaled colistin, or a combination of those administration routes. From 963 studies, we found 16 eligible studies with 1651 patients (61.6 ± 7.7 years) with multidrug-resistant pneumonia who had received either intravenous, inhaled colistin or a combined inhaled/intravenous administration. Our meta-analysis revealed higher rates of clinical cure (OR, 1.61) and microbiological eradication (1.37) in patients receiving combined intravenous/inhaled colistin than in those receiving intravenous colistin alone. Additional analyses revealed higher rates of nephrotoxicity (1.30) and mortality (1.44) in patients receiving intravenous colistin than in those receiving combined intravenous/inhaled colistin. We provide evidence showing improved clinical, morbidity, and mortality outcomes in patients with multidrug-resistant pneumonia receiving inhaled colistin or combined inhaled/intravenous colistin than those receiving intravenous colistin alone. These findings should help clinicians stratify the risks associated with different colistin administration routes to manage multidrug-resistant pneumonia.

The configuration, local motions, and related physics processes of the terrestrial magnetotail have been well studied, playing a key role in magnetotail dynamics. But characteristics of electron pitch-angle distribution (PAD), and the formation mechanisms, at different regions in the flapping magnetotail were not pointed out. Here, we study a current sheet crossing event detected by the Magnetospheric Multiscale Mission inside a magnetotail, and investigate the electron PAD of the event in detail. When the spacecraft are out of the current sheet, low-energy and high-energy electrons present field-aligned PAD and cigar-type PAD, respectively. This difference shows different motions of electrons. We proposed two possible explanation mechanisms: crossing a newly dipolarized magnetotail, or crossing the exhaust region of the reconnection region, and we discussed them in the paper adequately. Based on the dipolarized mechanism, for the first time, we point out that bouncing electrons could be the indicator of a newly dipolarized magnetotail. In addition, four other current sheet crossing cases with similar signatures are observed. Our study improves the understanding of current sheet dynamics and magnetotail configuration physics.

The prosperous development of both hardware and algorithms for quantum computing (QC) potentially prompts a paradigm shift in scientific computing in various fields. As an increasingly active topic in QC, the variational quantum algorithm leads a promising tool for solving partial differential equations on noisy intermediate scale quantum devices. Although a clear perspective on the advantages of QC over classical computing techniques for specific mathematical and physical problems exists, applications of QC in computational fluid dynamics to solve practical flow problems, though promising, are still at the early stage of development. To explore QC in practical simulation of flow problems, this work applies a variational hybrid quantum-classical algorithm, namely the variational quantum linear solver (VQLS), to resolve the heat conduction equation through finite difference discretization of the Laplacian operator. Details of the VQLS implementation are discussed by various test instances of linear systems. The effect of the number of shots on the accuracy is studied, which reveals a logarithmic relationship. Furthermore, the heuristic scaling of the VQLS with the precision ε, the number of qubits n and the condition number k validates its time complexity reported in the literature. In addition, the successful state vector simulations of the heat conduction equation in one and two dimensions demonstrate the validity of the present VQLS-based algorithm by proof-of-concept results. Finally, the heuristic scaling for the heat conduction problem indicates that the time complexity of the present approach is logarithmically dependent on the precision ε and linearly dependent on the number of qubits n.

In this study, we apply a method for wave analyses in space plasmas, to better understand the nature of plasma waves and turbulence. Such a method is based on four-spacecraft measurements of magnetic fields or electric fields; it calculates the phase velocity of each single-frequency wave by using the timing analysis, then divides the wave frequency by the phase velocity to obtain the wavevector, and finally solves the dispersion relation (ω–k relation) by considering all frequency channels, and thus is termed Dispersion RelAtion From Timing (DRAFT). Quantitatively, we define three parameters, match of amplitude (MOA), ratio of half-wavelength to spacecraft separation (λ/2R sc), and correlation coefficient (CC), to judge the reliability of this method. We illustrate the usage of this method and validate the efficiency of the three parameters by analyzing the Magnetospheric Multiscale data. We find that the DRAFT results are generally accurate under conditions MOA > 0.5, λ/2R sc > 1, CC > 0.8. As a support, we compare our method with the previous methods such as Means and singular value decomposition (SVD). We find that if the three criteria (MOA, λ/2R sc, CC) are satisfied, the DRAFT, Means, and SVD are consistent in resolving the wave normal angle. Such a comparison robustly validates the reliability and rationality of the DRAFT method. Using DRAFT, we successfully solve the dispersion relation of an Alfvén wave in Earth’s magnetosheath and obtain its three-dimensional K -spectrum. Our method should be useful to study the low-frequency waves and weak turbulence in space plasmas.

Spins in SiGe quantum dots are promising candidates for quantum bits but are also challenging due to the valley degeneracy which could potentially cause spin decoherence and weak spin-orbital coupling. In this work we demonstrate that valley states can serve as an asset that enables two-axis control of a singlet-triplet qubit formed in a double quantum dot without the application of a magnetic field gradient. We measure the valley spectrum in each dot using magnetic field spectroscopy of Zeeman split triplet states. The interdot transition between ground states requires an electron to flip between valleys, which in turn provides a g-factor difference $\Delta g$ between two dots. This $\Delta g$ serves as an effective magnetic field gradient and allows for qubit rotations with a rate that increases linearly with an external magnetic field. We measured several interdot transitions and found that this valley introduced $\Delta g$ is universal and electrically tunable. This could potentially simplify scaling up quantum information processing in the SiGe platform by removing the requirement for magnetic field gradients which are difficult to engineer., Comment: 4 figures

Global health resources have faced huge challenges from the pandemic coronavirus disease 2019 (COVID-19) since December 2019. Numerous clinical reports have focused on the association of serum amyloid A (SAA) levels with severe COVID-19. However, a systematic analysis synthesizing these findings has not been performed. This meta-analysis aims to systematically review the role of SAA levels in distinguishing among patients with mild, severe, and critical COVID-19.A comprehensive literature search was conducted in the PubMed, Embase, and Web of Science databases from the beginning of the COVID-19 outbreak to February 1, 2021. Two investigators independently reviewed suitable studies. Pooled standardized mean differences (SMDs), 95% confidence intervals (CIs), and correlation coefficients (r) were computed using a random-effects model.We included 19 of 317 titles identified by our search, involving a total of 1806 mild cases and 1529 severe cases. Compared with the mild group, the severe group had markedly higher SAA levels (SMD=1.155, 95% CI 0.89, 1.42). Subgroup analysis revealed that the SAA level differences between the severe group and the mild group were associated with age, sample size, and detection method. Sensitivity analyses showed the credibility and robustness of our results. In addition, in six studies involving 1144 patients with severe COVID-19 and 433 patients with critical COVID-19, SAA was significantly higher in patients with critical COVID-19 (SMD=0.476, 95% CI 0.13, 0.82).High circulating SAA levels were markedly associated with COVID-19 severity, especially for subjects aged less than 50 years, compared with patients with mild COVID-19. SAA concentrations were also significantly higher in patients with critical COVID-19 compared with those with severe COVID-19. Further studies in large cohorts are needed to confirm whether the SAA is a useful tool in discriminating among patients with stable COVID-19, those with acute exacerbations, and subjects without disease.

International audience; Betatron cooling, a plasma process losing particle energy in the perpendicular direction but reserving particle energy in the field-aligned direction, is a consequence of magnetic depression under the conservation of magnetic moment. Such process has been widely studied in the Earth's magnetosphere but has never been reported in other planetary environment. Here, by utilizing the Mars Atmosphere and Volatile EvolutioN (MAVEN) measurements, we report two events of betatron cooling in the Martian magnetotail. In one of the events, betatron cooling occurs in the suprathermal and energetic ranges of electrons, whereas in the other event, it occurs in the thermal-energy range. We quantitatively reproduce these two processes by using an analytical model. Gratifyingly, the cooling factor derived from the analytical model agrees well with the observation of magnetic depression. These results, for the first time demonstrating the betatron-cooling effect beyond the Earth, are useful to understand the electron dynamics in the planetary magnetosphere.

The anti-tumor mechanism of tumor treating fields (TTFields) is mainly through interfering with the dynamics of microtubule subunits in mitosis,which blocks the normal process of cell division and eventually leads to cell death.In recent years,relevant studies have found that TTFields still have immunological,molecular biological and other related anti-tumor mechanisms,and can induce reversible increase of cell membrane and blood-brain barrier permeability,which plays a synergistic role in combination with anti-tumor drugs.With the development of multi-system research,the specific treatment frequency,time and field strength of TTFields in different tumor treatments will be revealed.These research progress will further expand the application field of TTFields and benefit more patients.肿瘤电场治疗（TTFields）的抗肿瘤机制主要是通过干扰有丝分裂中微管亚基的动力学行为，使细胞正常分裂过程受阻，最终导致细胞死亡。近年来，相关研究发现TTFields尚存在免疫学、分子生物学等相关抗肿瘤机制，并可诱导细胞膜和血脑屏障通透性可逆性升高，在与抗肿瘤药物联合使用时发挥协同作用。随着多系统研究的不断开展，TTFields在不同瘤种治疗中的特异性治疗频率、时间和场强等将不断被揭示，进一步扩展TTFields的应用领域，惠及更多患者。.

This work presents the results of a detailed petrological study of olivine gabbro transformed to a different extent during the eclogite facies metamorphism. The textural features of cumulate crystallization in the rock at the magmatic stage are presented. Due to the significant transformations during eclogite facies metamorphism plagioclases were replaced by a fine-grained aggregate of high-pressure mineral paragenesis. Corona textures are developed along the boundaries of plagioclase (felsic) domains at the contacts with (Fe, Mg)-minerals during eclogite facies events. Mineral thermobarometry and phase equilibrium modeling provide P–T metamorphic conditions in relatively narrow temperature and pressure ranges: T = 680 ± 60°C and Р = 2.2 ± 0.4 GPa. This is in a good agreement with the previously established formation conditions of eclogites and garnet–amphibole peridotite from the same complex.

The paper presents the results of a detailed petrological study of olivine gabbro transformed to different extent by eclogite-facies metamorphism. Textural features of cumulate crystallization in the rock are presented. Plagioclases underwent the greatest alteration and replaced by finegrained aggregate during eclogite-facies metamorphism. Corona textures are developed along the boundaries of the plagioclase (felscic) domains at the contacts with (Fe,Mg)-minerals during eclogite facies event. The mineral thermobarometry and phase equilibrium modeling provide P-T metamorphic conditions in relatively narrow range of temperature 680±60 ᵒC and pressure Р=2,2±0.4 GPa. This is in a good agreement with the previously established conditions for the formation of eclogites and garnet-amphibole peridotite from the same complex.

The Marun-Keu Complex of high-pressure rocks comprises granitoids, gneisses, schists, gabbroids and peridotites, which are unevenly and variably metamorphosed to the eclogite facies. A representative sample of garnet–amphibole lherzolite from the Mount Slyudyanaya area shows a cumulate texture and well preserved magmatic mafic minerals (olivine and pyroxenes) but practically no preserved plagioclase. The eclogite-facies metamorphism produced corona textures of newly formed minerals: amphibole, garnet, orthopyroxene and spinel. The metamorphic parameters of the garnet–amphibole lherzolite were estimated by geothermobarometry and by modeling phase equilibria at Р ~ 2.1 GPa and T ~ 640–740°C and are well consistent with our earlier estimate of the formation conditions of eclogites in the area. Computer simulation of the crystallization process of the gabbroic melt with the COMAGMAT program package, using literature data on the composition of the least altered plagioclase peridotites and gabbroids from the Marun-Keu Complex, shows that the mafic and ultramafic rocks are genetically interrelated: they crystallized in a single magmatic chamber. According to the modeling, the origin of the cumulate texture in the lherzolite was controlled by the peritectic reaction Ol + melt → Opx at a pressure of 0.7–0.8 GPa and a temperature of 1255–1268°C. Differences between thermodynamic parameters in the eclogites and garnet peridotites are discussed within the framework of a tectonic model for subduction and subsequent exhumation of the Baltica paleocontinent.

The Marun-Keu Complex of high-pressure rocks comprises granitoids, gneisses schists, gabbroids, and peridotites, which are unevenly and variably metamorphosed to the eclogite facies. A representative sample of garnet–amphibole lherzolite from the Mount Slyudyanaya area shows a cumulate texture and well preserved magmatic mafic minerals (olivine and pyroxenes) but practically no preserved plagioclase. The eclogite-facies metamorphism produced corona textures of newly formed minerals: amphibole, garnet, orthopyroxene, and spinel. The metamorphic parameters of the garnet–amphibole lherzolite were estimated by geothermobarometry and by modeling phase equilibria at Р ~ 2.1 GPa and T ~ 640–740°C and are well consistent with our earlier estimate of the formation conditions of eclogites in the area. Computer simulation of the crystallization process of the gabbroic melt with the COMAGMAT program package, using literature data on the composition of the least altered plagioclase lherzolites and gabbroids from the Marun-Keu Complex, shows that the mafic and ultramafic rocks are genetically interrelated: they crystallized in a single magmatic chamber. According to the modeling, the origin of the cumulate texture in the lherzolite was controlled by the peritectic reaction Ol + melt → Opx at a pressure of 0.7–0.8 GPa and a temperature of 1255–1268°C. Differences between thermodynamic parameters in the eclogites and garnet peridotites are discussed within the scope of a tectonic model proposed for subduction and subsequent exhumation of the Baltica paleocontinent.

Utilizing high-resolution data from the Magnetospheric Multiscale mission, we present new observations of lower-hybrid drift waves (LHDWs) in terrestrial magnetotail reconnection with guide field levels of ∼70% and asymmetric plasma density (N high/N low ∼ 2.5). The LHDWs, driven by lower-hybrid drift instability, were observed in correlation with magnetic field and density gradients at separatrices on both sides of the reconnection current sheet. The properties of the LHDWs at both sides of the separatrices are different: (1) At high-density side separatrices, the LHDWs with wavelength kρ e ∼ 0.41 propagated away from the X-line mainly in the L–M plane; (2) at the low-density side separatrices, the LHDWs with wavelengths kρ e ∼ 0.76 and kρ e ∼ 0.35 propagated mainly along the outflow direction and current sheet normal. It is also found that the perpendicular magnetic field fluctuations were comparable to the parallel component. Wave potential of the LHDWs was 20% ∼ 35% of the electron temperature. The LHDWs contributed to electron demagnetization and energy dissipation. Our study can promote understanding of properties of LHDWs during magnetic reconnection.

Lower hybrid drift waves are commonly observed at plasma boundaries, playing an important role in plasma dynamics. Such waves have been widely investigated in the terrestrial magnetosphere but have never been reported in other planetary environments. Here, using the measurements from the Mars Atmosphere and Volatile EvolutioN mission, we present the first observation of electromagnetic lower hybrid drift waves at the edge of the current sheet on the dusk side of the Martian magnetotail, which should be locally excited rather than propagated from other regions. These plasma waves are associated with significant density gradients and magnetic field gradients. Based on the measured local plasma parameters and the sufficient condition for lower hybrid drift instability to be excited, we find that the proton density gradient is sharp enough to excite the lower hybrid drift instability. The analysis of the existence condition for lower hybrid drift instability indicates that these lower hybrid drift waves at the edge of the current sheet are generated through lower hybrid drift instability. The above results can improve our understanding of Mars’ magnetospheric dynamics.

钙化性主动脉瓣狭窄（CAS）是目前最常见的一种可能需要外科手术或导管介入干预的原发性瓣膜疾病，因缺乏有效的药物干预手段，大多数CAS患者会逐渐进展为重度主动脉瓣狭窄（SAS）。在临床实践中，有许多SAS患者处于无症状期，其中有些患者病情进展快速，预后较差。现行的心脏瓣膜病管理指南推荐对所有无症状SAS患者进行风险评估，低风险患者可密切临床随访，而高风险患者应尽早接受主动脉瓣置换术（AVR）以降低死亡率和不良心血管事件的发生率，因此明确风险评估的方法和确定行AVR的时机对于无症状SAS患者的诊疗至关重要。本文就无症状SAS患者的风险评估及其行AVR的时机进行简要综述。.

IgGIgG

Organically-derived biofertilizers and biostimulants, developed from harvested materials such as seaweed and waste from animal and fish processing, are currently the subject of much fundamental and applied research. These products have significant potential in reducing synthetic fertilizer inputs to horticultural, arable, and pasture-based agricultural systems, although there is frequently some ambiguity over the magnitude and consistency of any positive effects these products may have on plant performance. This study examined the effects of organically-derived plant growth promoters (PGPs) available in New Zealand on the early vegetative growth of 16 plant species maintained under glasshouse conditions. When applied as a root drench to low nutrient potting mix, the effects of the PGPs on seedling shoot growth were strongly related to the NPK contents of the applied solutions. Any positive effects on shoot growth were, on average, reduced when the seedlings were maintained in higher nutrient growing media. Applying the PGPs at concentrations twice, and four times, the recommended concentration, only caused further growth responses when the PGPs contained high levels of nutrients. Applying the PGPs as a foliar spray had negligible effects on shoot growth. Overall, the results of these trials suggest that the positive effects of applying some organically-derived PGPs on seedling growth are a function of the PGP nutrient content, and not due to any indirect effects related to phytohormone pathways or modification of rhizosphere microorganisms.