Search

5 H-Benzo[ b]carbazoles were prepared through a tandem reaction between 2-ethynyl- N-triphenylphosphoranylidene anilines and α-diazoketones through ketenimine intermediates in moderate-to-good yields. By using this approach, benzo[ b]benzo[5,6]indolo[3,2 -h]carbazoles, fluoreno[9,1- ab]carbazoles, and fluoreno[9,1- ab]fluoreno[1′,9′:5,6,7]indolo[3,2- h]carbazoles were constructed in one pot. Moreover, the resulting products emitted light within the range 410-521 nm, with quantum yields of up to 62 %. [ABSTRACT FROM AUTHOR]

Abstract: The double-helicate dinuclear silver(I) complex [Ag2L2](SO3CF3)2 (1) was obtained by reaction of AgSO3CF3 with 4′-phenyl-terpyridine (L). Each Ag+ ion is coordinated by two N-atoms from one of the ligands and by one N-atom of the other ligand, forming an irregular Ag2N6 bi-triangle geometry, with a metallic bond between the two silver ions. Complex 1 reacts with potentially bidentate ligands (L1), such as 9,10-bis(diphenylphosphino)anthracene (PAnP), 4,4′-dipyridyl or bis(diphenyl phosphino)methane (DPPM), to give the corresponding dinuclear complexes with bridging L1, [Ag2L2(μ-L1)](SO3CF3)2 (L1 =PAnP 2, 4,4′-dipyridyl 3 or DPPM 4), whereas on reaction with PPh3 forms the mononuclear complex [AgL(PPh3)](SO3CF3) 5. Reaction of 1 with the potentially tridentate ligand tris(2-diphenylphosphinoethyl)amine (NP3) results in complete decomposition of the coordination spheres to form [Ag(NP3)](SO3CF3) 6. Compound 1 shows a strong fluorescence in the solid state with its excitation band at 383.5nm, the emission band at 535.5nm and the lifetime of 4.20ns, but the derived complexes do not show fluorescent properties. The photoluminescence of 1 in various solvents was also studied. The complexes were characterized by 1H NMR, elemental analysis, IR, MS, UV and single crystal X-ray diffraction. [Copyright &y& Elsevier]

C34H27N4O7.5SCo, monoclinic, Cc (no. 9), a = 23.7684(16) Å, b = 13.5683(10) Å, c = 10.0223(7) Å, β = 94.405(2)° V = 3222.6(4) Å3, Z = 4, Rgt(F) = 0.0427, wRref(F2) = 0.0815, T = 293(2) K. [ABSTRACT FROM AUTHOR]

C18H22N4NiO4, orthorhombic, Pna21 (no. 33), a = 8.9924(5) Å, b = 17.1818(10) Å, c = 12.1009(7) Å, V = 1869.66(19) Å3, Z = 4, Rgt (F) = 0.0328, wRref (F2) = 0.0798, T = 293 K. [ABSTRACT FROM AUTHOR]

Cyclopenta[b]quinolines and cyclohexa[b]quinolines were prepared via the reactions of α-diazo ketones with N-(2-cyclopropylidenemethylphenyl)phosphanimines and N-(2-cyclobutylidenemethylphenyl) phosphanimine, respectively. The reaction proceeds in a cascade involving ketenimine formation, 6 π-electron ring closure, and 1,3-alkyl shift. A similar approach was developed for the synthesis of dihydropyrrolo-[2,3-b]quinolines from N-(2-cyclopropylidenemethylphenyl)phosphanimines and isocyanates., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Objective: The aim of this study is to discuss the curative effect of introperitoneal hyperthermic perfusion chemotherapy(IHPC) combined with systemic neoadjuvant chemotherapy on the gastric cancer patients with peritoneal carcinomatosis., Methods: Sixty-four patients with gastric cancer and peritoneal carcinomatosis who were hospitalized in the Department of Gastrointestinal Surgery of First Hospital of Jilin University from December 2006 to December 2013. After peritoneal carcinomatosis was confirmed during laparoscopic exploration, FOLFOX6 (oxaliplatin and calcium folinate and 5-Fu) was performed for systemic chemotherapy. One course was 14 days and a complete treatment includes four courses. At the same time, patients underwent peritoneal catheter insertion and received IHPC(5-Fu 1 500 mg/m(2) and Cisplatin 35 mg/m(2) were added into 0.9% NaCl solution 2 000 ml, the infusion velocity was 35-45 ml/min, infusion time was 45-60 minutes, the temperature was controlled to 41°C). A comprehensive evaluation was taken after the fourth course of treatment before operation. Further surgical therapy was performed according to the assessment result., Results: Sixty-four patients received IHPC combined with systemic chemotherapy. Thirty-two patients(50.0%) had partial response, 18(28.1%) stable disease, and 14(21.9%) progressive disease after chemotherapy. No severe complications or death occurred during the neoadjuvant chemotherapy. Thirty-two patients(50.0%) received radical resection, 10(15.6%) palliative operation, and another 22 patients(37.4%) didn't comply with inclusion criteria of operation. Patients receiving operation had a median survival time of 678 days, which was significantly longer than patients without operation, with a median survival time of 251(χ(2)=23.34, P=0.02)., Conclusions: IHPC combined with systemic chemotherapy is an effective therapeutic method for gastric cancer patients with peritoneal carcinomatosis in terms of reducing preoperative tumor load and achieving radical resection.

Objective: To investigate the effect of omega-3 polyunsaturated fatty acids (PUFA) on postoperative inflammatory response and clinical efficacy in gastric cancer patients with nutritional risk., Methods: All patients with gastric cancer in our department from June 2013 to January 2014 undergoing radical gastrectomy were prospectively enrolled in the study. Patients who matched the selection criteria were randomly divided into two groups: trial group (with omega-3 PUFA in parenteral nutrition) and control group (without omega-3 PUFA in parenteral nutrition). Levels of inflammatory factors (serum CRP, TNF-α, IL-1, IL-6, IL-10) and nutrition-related proteins (prealbumin, retinol conjugated protein and transferrin) were compared between the two groups before operation and 2, 4 and 6 days after operation. Incidence of postoperative systemic inflammatory response syndrome (SIRS) and other indicators associated with efficacy were compared between the two groups as well., Results: Forty-seven patients were finally included in this study with 21 patients in the trial group and other 26 in the control group. There were no significant differences of inflammatory factors and nutrition-related proteins between the two groups before operation (all P>0.05). In the 6th days after operation, the levels of proinflammatory cytokines, including CRP, IL-1 and IL-6 were significantly lower in the trial group as compared to the control group, while the level of IL-10 (inhibiting inflammatory cytokine) was higher in the trial group, as well as levels of nutrition proteins(all P<0.05). The trial group had significantly lower rate of SIRS than the control group [57.1%(12/21) vs. 84.6% (22/26), P=0.036]. Compared with the control group, patients in the trial group had shorter bowel sound recovery time [(12.3±1.1) d vs. (3.1±1.3) d, P=0.025], earlier passage of flatus [(3.1±1.0) d vs. (3.9±1.2) d, P=0.025] and shorter hospital stay [(9.4±2.1) d vs. (10.9±2.5) d, P=0.038], but there was no difference in postoperative complication rate between the two groups (P=0.678)., Conclusions: Omega-3 PUFA can reduce the release of inflammatory promoters, promote the release of inhibiting inflammatory cytokine IL-10, decrease the incidence of SIRS, improve patients' nutritional state, expedite the recovery of gastrointestinal function and shorten patients' recovery time.

Purpose: This study aimed to review the clinicopathological, histochemical, and prognostic features of Alpha-Fetoprotein (AFP) positive gastric cancer., Patients and Methods: Six hundred and fifty one patients with gastric cancer who underwent gastrectomy between January 2009 and December 2012 at The First Hospital of Jilin University were enrolled in the study. Among them, 45 patients were identified as AFP positive gastric cancer. The clinicopathologic characteristics and prognosis of the AFP positive gastric cancer patients were analyzed., Results: Among the 45 AFP positive patients, serum levels of AFP were < 100 µg/L in nine patients. The histological classification of 45 patients was as follows: hepatoid type, 25 (55.6%) cases; fetal gastrointestinal type, 12 (26.7%) cases; yolk sac tumor type, 2 (4.4%) cases; and mixed type, 6 (13.3%) cases. Twenty nine (64.4%) cases were AFP positive by immunohistochemical analysis; we found no significant difference in AFP positivity and histologic type. However, the differences in the number of metastasis lymph nodes, the maximum tumor diameter, pathological stage, vascular invasion and liver metastasis between the AFP positive group and the negative group were significant. At the same T stage, the liver metastasis status of the AFP positive group was higher than that of the negative group. The AFP positive group had a much poorer prognosis than the negative group., Conclusion: AFP positive gastric cancer is associated with aggressive behavior and poorer prognosis compared to that of AFP negative gastric cancer.

A facile and efficient electrocyclization for the synthesis of polyfunctionalized benzene and naphthalene derivatives was reported. As a result of the ready availability of starting materials and simple operation, this type of reaction has potential utility in organic synthesis.

The title Cu(II) complex, [CuBr(2)(C(21)H(15)N(3))]·0.5H(2)O, was obtained by the hydro-thermal reaction of copper(II) bromide, 4'-phenyl-2,2':6',2''-terpyridyl (4'-Ph-terpy or L) and sodium citrate in water in 31% yield. There are two unique complex mol-ecules and a water mol-ecule in the asymmetric unit. The Cu(II) cation is ligated by three N atoms of L and two bromide anions, forming an irregular CuN(3)Br(2) polyhedron with a distorted square-pyramidal coordination geometry. In the crystal structure, O-H⋯Br hydrogen bonds link the mol-ecules in a three-dimensional network.

The title complex, [Ag(2)(C(7)H(7)O(3)S)(2)(C(25)H(22)P(2))(2)]·H(2)O, was obtained by the reaction of silver toluene-sulfonate with diphenyl-phosphinomethane (dppm) in acetonitrile. There are two unique half-mol-ecules of the complex in the asymmetric unit, together with one water mol-ecule, which is disordered over two positions with site occupancy factors of 0.6 and 0.4. In each centrosymmetric neutral dimeric mol-ecule, two Ag atoms are bridged by a pair of dppm ligands to give an eight-membered Ag(2)P(4)C(2) ring with a distorted AgOP(2) trigonal-planar environment. The Ag-Ag distances of 2.9215 (9) and 3.027 (1) Å indicate a direct bonding inter-action.