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The coadsorption of anionic and cationic pollutants on adsorbents holds considerable importance in the development of relevant removal technologies and the understanding of pollutant transport in complex environmental media. Herein, tungsten (W), an emerging contaminant, and nickel (Ni) were chosen as two differently charged inorganic pollutants to investigate their removal characteristics on a magnesium-aluminum layered double hydroxide (LDH) prepared via microwave radiation. In the single systems, the amount of adsorbed W on LDH was initially increased and then decreased with increasing initial W concentration. In concentrated W solutions, LDH dissolution was intensified, accompanied by the intercalation and polymerization of W in the interlayer space. Among the various oxyanions, phosphate showed the most substantial inhibition on W uptake. In contrast, uptake of Ni was enhanced with the rapider adsorption rate at higher concentrations, due to the isomorphic substitution and precipitation. Coexisting cations of similar sizes competed with Ni to substitute with Mg, resulting in reduced uptake, except in the case of Fe 3+ which disintegrated the LDH structure. In a binary system, the uptakes of W and Ni increased by 2.65 and 1.80 times, respectively, compared to their corresponding single systems, indicating an intriguing synergistic effect. Furthermore, the presence of Ni restored the LDH's ability to remove W in the presence of coexisting H 2 PO 4 - , SO 4 2- , and CrO 4 2- . However, due to the presence of W, the coexisting Co 2+ and Zn 2+ inhibited Ni uptake more significantly. The crystallinity decrease of LDH was induced and identified as the cause of the uptake synergy between W and Ni. These findings provide valuable insights for the development of efficient multifunctional adsorbents and enhance our understanding of the transfer dynamics of W in the presence of coexisting substances., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Wuhui Luo reports financial support was provided by National Natural Science Foundation of China. Wuhui Luo reports financial support was provided by Jiangxi Provincial Natural Science Foundation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Near-infrared (NIR) fluorescence imaging-guided photodynamic therapy (PDT) technology plays an important role in treating various diseases and still attracts increasing research interests for developing novel photosensitizers (PSs) with outstanding performances. Conventional PSs such as porphyrin and rhodamine derivatives have easy self-aggregation properties in the physiological environment due to their inherent hydrophobic nature caused by their rigid molecular structure that induces strong intermolecular stacking π-π interaction, leading to serious fluorescence quenching and cytotoxic reactive oxygen species (ROS) reduction. Meanwhile, hypoxia is an inherent barrier in the microenvironment of solid tumors, seriously restricting the therapeutic outcome of conventional PDT. Aforementioned disadvantages should be overcome urgently to enhance the therapeutic effect of PSs. Novel NIR fluorescence-guided type I PSs with aggregation-induced emission (AIE), which features the advantages of improving fluorescent intensity and ROS generation efficiency at aggregation as well as outstanding oxygen tolerance, bring hope for resolving aforementioned problems simultaneously. At present, plenty of research works fully demonstrates the advancement of AIE-active PDT based on type I PSs. In this review, cutting-edge advances focusing on AIE-active NIR type I PSs that include the aspects of the photochemical mechanism of type I ROS generation, various molecular structures of reported type I PSs with NIR fluorescence and their design strategies, and typical anticancer applications are summarized. Finally, a brief conclusion is obtained, and the underlying challenges and prospects of AIE-active type I PSs are proposed., (© 2023 John Wiley & Sons Ltd.)

De novo variants in QRICH1 (Glutamine-rich protein 1) has recently been reported in 11 individuals with intellectual disability (ID). The function of QRICH1 is largely unknown but it is likely to play a key role in the unfolded response of endoplasmic reticulum stress through transcriptional control of proteostasis. In this study, we present 27 additional individuals and delineate the clinical and molecular spectrum of the individuals (n = 38) with QRICH1 variants. The main clinical features were mild to moderate developmental delay/ID (71%), nonspecific facial dysmorphism (92%) and hypotonia (39%). Additional findings included poor weight gain (29%), short stature (29%), autism spectrum disorder (29%), seizures (24%) and scoliosis (18%). Minor structural brain abnormalities were reported in 52% of the individuals with brain imaging. Truncating or splice variants were found in 28 individuals and 10 had missense variants. Four variants were inherited from mildly affected parents. This study confirms that heterozygous QRICH1 variants cause a neurodevelopmental disorder including short stature and expands the phenotypic spectrum to include poor weight gain, scoliosis, hypotonia, minor structural brain anomalies, and seizures. Inherited variants from mildly affected parents are reported for the first time, suggesting variable expressivity., (© 2021 Wiley Periodicals LLC.)