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In this work, the electron-phonon, phonon-phonon, and phonon structure scattering mechanisms and their effect on the thermal and thermoelectric properties of a silver nanowire (AgNW) is investigated in the temperature range of 10 to 300 K. The electron-phonon scattering rate decreases with the increase of temperature. The phonon-phonon scattering rate increases with temperature and becomes greater than the electron-phonon scattering rate when the temperature is higher than the Debye temperature (223 K). The rate of phonon structure scattering is constant. The total phonon scattering rate decreases with temperature when the temperature is lower than about 150 K, and increases when the temperature is higher than 150 K. Correspondingly, the temperature dependent variation trend of the lattice thermal conductivity is opposite diametrically to that of the total phonon scattering rate. The thermoelectric properties of the AgNW are strongly coupled with the thermal conductivity

BACKGROUND: To explore the expression and clinical significance of the cytokinesis-related gene NUF2 in kidney renal clear cell carcinoma (KIRC). METHODS: Gene expression profiles of KIRC patients were extracted from The Cancer Genome Atlas (TCGA) database. The differences in NUF2 mRNA expression between patients and controls, as well as the relationship between the clinical characteristics and overall survival of the patients, were analyzed. The expression of NUF2 protein in 83 cancer tissues and para-cancerous tissues was detected to analyze the relationship with clinical characteristics. Gene Set Enrichment Analysis (GSEA) was used to investigate the possible regulatory pathways of the NUF2 in the development of KIRC. RESULTS: NUF2 mRNA was significantly higher in patients with KIRC, and the prognosis of patients with high expression of NUF2 mRNA was significantly worse than those with low expression, and was related to the AJCC stage, T stage, lymph node metastases, and distant metastases. NUF2 mRNA was an independent prognostic risk factor for KIRC patients. The expression of NUF2 protein was significantly higher in KIRC patients than in paraneoplastic tissues and was markedly associated with the pathological grade. In addition, the high expression of NUF2 was associated with the upregulation of pathways such as homologous recombination and DNA replication. CONCLUSIONS: NUF2 may act as an independent prognostic biomarker for predicting the survival of KIRC patients.

In this paper, the cold launch test platform is taken as the research object, theoptimization model of this test platform is established by using topology optimization method. First,the topology optimization goal of the structure is determined, and then the constraints are carriedout. Finally, optimized and non-optimized areas are identified, and the result is processed. Afteroptimization, the quality of the test platform was reduced by 2.9 tons under the conditions of use.

Objectives: To synthesize folate acid conjugated quantum dots (QDs) by a simple and green method and explore endocytosis of the QD-folic acid conjugates (FA-QDs) into hepG2 cells. Methods: CdS QDs were prepared using stearic acid as synthetic medium, and were conjugated with mercaptoacetic acid (MAA) to be water-soluble. Then folic acid moiety was coupled to the surface of the QDs using EDC (1-ethyl-3-(3-dimethylamino propyl)carbodiimide) as a coupling agent. The CdS QDs and FA-QDs were characterized by X-ray spectroscopy (XRD), transmission electron microscopy (TEM), spectro fluorimetry and infrared spectroscopy. Endocytosis of the FA-QDs into hepG2 cells was observed by confocal microscopy and TEM. Results: TEM shows that the CdS QDs and FA-QDs were spherical in shape and had a diameter of 10 nm. Fluorescence spectrum of the QDs also shows their narrow size distribution. Confocal microscopic and TEM results show that FA-QDs were successfully internalized into the hepG2 cells. In addition, confocal results show that when the cells were first be saturated with excess free FA, the endocytosis of the FA-QDs became less, and CdS QDs that were not conjugated with FA were not able to be internalized into the hepG2 cells. Conclusions: The FA-QDs can be synthesized by a simple and green method and be used to successfully target tumor cells: hepG2 cell lines, which was probably mediated by the FA receptor.

The mutation MYBPC3-E334K is a culprit mutation of hypertrophic cardiomyopathy (HCM). The pathogenicity of MYBPC3-E334K is conflicting in ClinVar because of the limited segregation data and the relatively high frequency in gnomAD (0.03% overall, with 0.3% in East Asians and 0.8% in Japanese). The main aim is to clarify the clinical importance and phenotype-genotype correlations in subjects with or without MYBPC3-E334K alone. The prevalence of MYBPC3-E334K was sequenced in 1017 HCM unrelated probands. The clinical features, morphology phenotypes, and electrical phenotypes were further analyzed according to the phenotype and genotype status in families with single-mutation MYBPC3-E334K. Nine of 1017 (0.88%) unrelated HCM probands were detected harboring MYBPC3-E334K, and three of them harbored a second variant in sarcomere protein gene. Family study and co-segregation analyses indicated that patients with single-mutation MYBPC3-E334K showed autosomal dominant mode of inheritance with incomplete penetrance. The overall disease penetrance was 52.6%, and the disease penetrance was higher in males than in females (100% in men vs 25% in women, p = 0.003). The mean age at diagnosis of males was approximately 25 years younger than females (36.57 ± 18.65 vs 62.33 ± 12.10, p = 0.062). The variant MYBPC3-E334K was classified as a likely pathogenic variant, and a second sarcomere variant did not reveal obvious cumulative effects. The patients harboring single-mutation MYBPC3-E334K had incomplete penetrance, and males demonstrated higher penetrance and early onset HCM than females. A second sarcomere variant did not reveal obvious cumulative effects.

Three typical porous solid wastes, including livestock manure, crop straw, and coal mining waste, were used as raw materials to prepare cattle manure charcoal, straw charcoal, and coal gangue charcoal by low-oxygen controlling temperature carbonization and calcination. Batch adsorption experiments of sulfamethazine (SMZ) in water were carried out. Adsorption kinetics and isothermal adsorption equilibrium were used to investigate the adsorption characteristics of SMZ on cattle dung charcoal, straw charcoal, and coal gangue charcoal, and the adsorption mechanism was discussed by means of field-electron scanning electron microscope, Fourier transform infrared spectroscopy, Boehm titration, Brunauer-Emmett-Teller measurement, and zeta potentiometric titration. The results showed that the adsorption of SMZ on the three carbon materials reached equilibrium at 24 h. The adsorption kinetics of SMZ on three kinds of carbon materials agreed with the quasi-second-order kinetics equation.

In this study, an optimal method used to extract

BACKGROUND This study aims to investigate the relationship between serum uric acid (SUA) and the severity of diabetic nephropathy (DN) and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). METHODS A total of 2961 patients were enrolled in the present cross-sectional study. The severity of DN was determined by 24-hour urinary albumin excretion (UAE), which was classified as normal (UAE

In this study, an optimal method used to extract Annona squamosa pericarp oil (ASPO) was established according to the response surface model. The yield of ASPO was 1.45%. 8 fatty acids were identified from ASPO by GC-MS. Among them, (9Z)-9-Octadecenoic acid was abundant and accounted for 49.65%. The anti-hepatoma activities of ASPO were investigated against SMMC-7721 cell line in vitro and H22 cell line in vivo. Proteins associated with apoptosis in tumour tissue were quantified by western blot assay. The result revealed that ASPO had significant anti-hepatoma activities with IC50 value of 15.96 μg/mL in vitro and tumour inhibition rate of 54.14% at 50 mg/kg dose in vivo. Protein analysis showed that ASPO activated apoptosis by down-regulating Bcl-2, up-regulating Bax, cleaving caspase 9, cleaving caspase 8 and cleaving caspase 3 proteins. The possible mechanisms of apoptosis induced by ASPO were related to Fas/FasL/caspase-8/caspase-3 and Bcl-2/bax/caspase-9/caspase-3 pathways.

The substitution of rare-earth ions has been recognized as an effective way to modify the multiferroic properties, especially to realize the electric field-controlled magnetism in BiFeO3 ceramics, in which the symmetry modulation of R3 c/ Pna21 and the unlocked ferromagnetism through breaking the cycloidal spin structure are the key issues. Here, the enhancement of ferroelectric polarization and weak ferromagnetism are investigated in Bi1− xLa xFeO3 ceramics together with the magnetoelectric coupling coefficient αME with the development of the Pna21 phase. The expected electric field-controlled magnetism is achieved at the phase boundary through the electric field-induced transition of Pna21/ R3 c, where the variation of magnetization reaches 34.18 emu/mol (58.95%) at x = 0.18 after poling.

Oxygen-deficient tungsten bronze ceramics with general formula Sr 4 Sm 2 Ti 4+2 x Nb 6–2 x O 30- x are synthesized by standard solid-state reaction. The sintering characteristics, crystal structure and dielectric properties have been investigated. Dense ceramics can be obtained by sintering at 1300 °C for all compositions. The x = 0.25 sample has the highest density > 97%. The sharp dielectric peaks and strong endothermic differential scanning calorimetry (DSC) peaks are observed for x = 0 and 0.1 compositions, which suggest the ferroelectric transition. For x = 0.25, the ferroelectricity is weakened, and the low temperature relaxation enhanced obviously. Therefore, the x = 0.25 composition indicates a high dielectric constant e ~ 200, loss tangent tan δ

Objective To explore the correlation of circRNA expression level and severity of depression in major depressive disorder (MDD) patients in order to provide solid scientific evidences for diagnosis and prognosis evaluation of MDD. Methods circRNA array was performed in peripheral blood mononuclear cells (PBMCs) obtained from 5 MDD patients and 5 controls, and then real-time fluorescence quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to verify the top 10 circRNAs with the highest fold change values. All the MDD patients were assessed by Hamilton Depression Scale (HAMD). Results The change of expression level of circRNA_103636 was negatively correlated to anxiety/somatization and cognitive disorder; the change of expression level of circRNA_100679 showed a significantly positive correlation with weight and hopelessness (P＜0.05). Regression analysis demonstrated that the alteration of circRNA_100679 expression accounted for 13.9% and 11.1% respectively of weight and hopelessness; expression levels of circRNA_104121, circRNA_102802 and circRNA_104953 could predict retardation (P＜0.05) and accounted for 16.9% of variances; expression levels of circRNA_104600 and circRNA_103636 could significantly predict variance of sleep disorder (P＜0.05, the accounting percentage was 15.4%). Expression levels of circRNA_002143, circRNA_102802, circRNA_103636, circRNA_100679 and circRNA_104953 showed statistical difference between upper-score group and lowerscore group (P＜0.05). ROC analysis suggested expression level of circRNA_100679 in PBMCs had neutral predictive efficacy on depressive severity (AUC=0.708, P＜0.05, 95% confidence interval: 0.523-0.894). Conclusions Altered expression of circRNA_100679 may be involved in MDD pathogenesis and may serve as a biomarker for MDD. Moreover, expression levels of hsa_circRNA_002143 and circRNA_103636 might be closely related to severity of symptoms in MDD patients. DOI: 10.11855/j.issn.0577-7402.2018.06.10

Antiferroelectrics are of interest due to their high potential for energy storage. Here, we report the discovery of pinched, polarization-vs.-electric field (P–E) hysteresis loops in the lead-free tungsten bronze ferroelectrics Ba4Sm2Ti4Nb6O30 and Ba4Eu2Ti4Nb6O30, while a broad, single P–E hysteresis loop was observed in the analogue compound Ba4Nd2Ti4Nb6O30. Pinched P–E loops are similar to antiferroelectric hysteresis loops, but in perovskites, they are mostly caused by an extrinsic, internal bias field due to defects, which block domain wall motion. We show that the pinched P–E loops are caused by an intrinsic effect, i.e., by the electric-field-induced phase transition from a non-polar incommensurate to a polar commensurately modulated crystal structure. The in situ electron diffraction results show the coexistence of commensurate polar structural modulation and incommensurate non-polar modulation during the ferroelectric transition and within the ferroelectric phase below the transition temperature. This phase coexistence is the reason for the small remanent polarization. An external electric field transforms the incommensurate component into a commensurate one, and the polarization increases. This new mechanism for pinched P–E hysteresis loops in ferroelectrics not only indicates a new direction for the development of Pb-free ferroelectric materials for energy storage but also significantly contributes to the physical understanding of ferroelectricity in materials with a tungsten bronze structure. An unusual switching action normally associated with crystal defects may be reproduced on demand in eco-friendly ceramics. Electric fields can modulate the polarization of ferroelectric materials, which have spontaneously aligned electric dipoles, and antiferroelectrics, which have adjacent dipoles pointing in opposite directions. These kinds of polarization switches have applications in energy-storage and memory devices. Now, Xiang Ming Chen from Zhejiang University in China and colleagues report compounds that exhibit characteristics of both polar and nonpolar switches. The team found that by modifying the size of rare earth ions encased in lead-free tungsten bronze ceramics, they could create a distinct ‘pinch’ in graphs that plot the polarization response to an electric field—a clear feature of bistable ferroelectric materials. Electron diffraction measurements suggest the pinched hysteresis loops appear from internal, field-induced phase transitions. The present electric-field induced phase transition from non-polar incommensurate to ferroelectric commensurate phase in Pb-free dielectrics with tungsten bronze structure has been proved to be the structural origin of the pinched P-E loops. This new mechanism for pinched P-E hysteresis loops in ferroelectrics not only indicates a new direction to develop Pb-free ferroelectric materials for energy storage but also contributes significantly to physical understanding of ferroelectricity in materials with tungsten bronze structure.

Rare earth ion (RE)-substitution has been recognized as an effective way for improving multiferroic properties especially for realizing the electric field-controlled magnetism in BiFeO3 ceramics, where the symmetry modulation of R3c-Pna21-Pbnm and unlocking ferromagnetism by destroying the cycloidal spin structure are the key points. In Lu-substituted BiFeO3 ceramics, however, the Pna21 phase is not involved. In the present work, La/Lu co-substitution was investigated to involve the Pna21 phase in BiFeO3 ceramics. The phase transition from R3c to Pna21 occurred with an increase in x, and the mixed structure of R3c, Pna21, and Pbnm phases was determined in Bi0.82−xLaxLu0.18FeO3 ceramics. The greatly enhanced ferroelectric polarization and the switching from antiferromagnetic to the weak ferromagnetic state through the destruction of the cycloidal spin structure were achieved. Subsequently, the direct magnetoelectric coupling coefficient αME up to 2.02 mV/cm Oe was obtained. The increased effective ionic radius of RE in the present ceramics played a key role in involving Pna21 phase in RE-substituted BiFeO3 ceramics, and the critical value was about 0.104 23(2) nm.

Ba5RZr3Nb7O30(R=La, Nd, Sm) lead free relaxor ferroelectrics were prepared by a standard solid state reaction process, and the influence of A and B site ion occupation on the dielectric characteristics especially the relaxor nature were investigated systematically. Tetragonal tungsten bronze structure with space group P4/mbm was determined for all compositions, ion cross distribution by Ba2+ and R3+ in A1 site was observed, while A2 site was only occupied by Ba2+. Selected area electron diffraction patterns confirmed the existence of incommensurate superlattice modulation. Furthermore, temperature and frequency dependences of the dielectric properties showed a broad permittivity peak with strong frequency dispersion, following well the Vogel–Fulcher relationship. The maximum dielectric constant temperature increased gradually with the A1 site ion size decreasing. Slim P-E hysteresis loops were obtained at room temperature for all compositions. Meanwhile, micro ferroelectric domains were observed in Ba5SmZr3Nb7O30. For Ba4R2Zr4Nb6O30 and Ba5RZr3Nb7O30 (R=Nd, Sm), the transition from normal ferroelectric to relaxor behavior originates from the increased tA1, which is a result of cross distribution at A1 site. Compared with Ba5RTi3Nb7O30, Zr substitution at B site enhances the relaxor nature. This article is protected by copyright. All rights reserved.

Objective To explore the correlation of circRNAs' expression level to the negative- and positive symptoms of patients with schizophrenia (SZ). Methods Gene chip screening was performed with the peripheral blood samples from each five of SZ patients and normal controls. Nine circRNAs showing differentiate expression were confirmed, and further verification was done by real-time fluorescence quantitative PCR in 102 SZ patients and 103 normal controls. All the SZ patients were assessed with Positive and Negative Symptom Scale (PANSS). Results It was revealed that the expression levels of circRNA_102101, circRNA_102315, circRNA_104597, circRNA_101835 and circRNA_101836 were significantly down-regulated (P

This study investigated the anti-hepatoma activity of different extracts from A. squamosa pericarps, phytochemistry of the ethyl acetate (EtOAc) fraction and possible anti-hepatoma mechanism of active constituents. The anti-hepatoma activity of different extracts from A. squamosa pericarps were evaluated by MTT assay against SMMC-7721 cells in vitro and verified by using H22 xenografts bearing mice. Phytochemical investigation of the active pericarp extract was carried out. The pro-apoptosis and cycle arrest effects of active constituents were observed by fluorescent microscope and flow cytometry. Western blot assay was conducted to find the possible anti-hepatoma mechanisms of active constituents. The result showed that EtOAc extract was the active fraction. Two ent-kaurane diterpenoids, named ent-kauran-16-en-19-oic acid and ent-kauran-15-en-19-oic acid, were isolated from the active EtOAc fraction. The pro-apoptosis and G1 phase arrest effects of these diterpenoids were found. Western blot assay showed that ent-kauran-16-en-19-oic acid could activate caspase-3,-8,-9, up-regulate of Bax and down-regulate of Bcl-2.

A novel pillared-layered entangled luminescent metal–organic framework [Zn2(bpdc)2(BPyTPE)] (1) (BPyTPE = (E)-1,2-diphenyl-1,2-bis(4-(pyridin-4-yl)phenyl)ethene) has been designed and constructed. The solvent-free 1 exhibits strong blue-green emission with an excellent fluorescence quantum yield of 99% and provides a facile and reversible method to sensitively and quantitatively detect trace pesticide of 2,6-dichloro-4-nitroaniline.

Oxygen-deficient tungsten bronze ceramics with general formula Sr5SmTi3+2xNb7−2xO30−x (x = 0, 0.1, 0.25) are prepared. The effects of oxygen deficiency on the crystal structure, dielectric and ferroelectric properties are investigated. With increasing oxygen deficiency, the crystal structure becomes less stable and the lattice shrinks, while the ferroelectricity is weakened, and the low temperature relaxation enhanced. Commensurate superlattices observed in Sr5SmTi3Nb7O30, corresponding to the onset of the ferroelectric transition as reported previously. In compositions with x = 0.1 and 0.25, two factors that A-site cross occupancies and disturbance of oxygen vacancies on the ferroelectric order are noticed and related to the change from ferroelectric behavior to diffuse one. Three orders of incommensurate superlattice reflections are observed in x = 0.1 and 0.25 compositions. The first-order incommensurate superlattice reflections appear at positions (h + 1/4 − δ, k + 1/4 − δ, l + 1/2), reflecting the common feature in tungsten bronzes with relaxor or diffuse ferroelectric nature. The second-order incommensurate superlattice reflections are observed on the (00l) (l = 0, 1, 2, 3, …) planes around the (h + 1/2, k + 1/2, l) positions, while the third-order incommensurate superlattice reflections are observed on the (00l) (l = 1/2, 3/2, …) planes, by the side of the first-order ones. The appearance of higher-order is believed to reduce the high structural energy induced by the oxygen deficiency.

It has become very important to search for Pb-free ferroelectric new materials because of increasing environmental concerns, and the tungsten bronze family might provide great potential for this challenge due to the various possibilities of structural tailoring. In the present work, a zirconate niobate ferroelectric new system Ba4R2Zr4Nb6O30 (R = La, Nd, Sm) with a filled tetragonal tungsten bronze structure has been synthesized and investigated. The ferroelectricity and polar order are characterized together with the crystal structure. The present materials show a crossover from relaxor to normal ferroelectric features upon increasing the A-site ionic radii difference (Δr). The relaxor behavior in Ba4La2Zr4Nb6O30 is associated with incommensurate modulation, while commensurate structural modulation dominates the normal ferroelectric transition in Ba4Nd2Zr4Nb6O30 and Ba4Sm2Zr4Nb6O30. Compared with titanate niobate tungsten bronzes, the present materials exhibit a stronger relaxor nature. The ferroelectric transition in Ba4Nd2Zr4Nb6O30 and Ba4Sm2Zr4Nb6O30 shows first order features with an unusually large thermal hysteresis (>100 K), and is followed by a low temperature dielectric relaxation. Micro polar regions are detected for Ba4La2Zr4Nb6O30 under piezoresponse force microscopy (PFM), while the coexistence of macro ferroelectric domains and micro polar regions is observed in the low temperature relaxation region for Ba4Nd2Zr4Nb6O30 and Ba4Sm2Zr4Nb6O30, and the micro polar regions can grow into the macro domains under a high electric field. An abnormal decrease is observed at lower temperatures in the curve of remanent polarization vs. temperature for Ba4Nd2Zr4Nb6O30 and Ba4Sm2Zr4Nb6O30, which is attributed to the disruption of the ferroelectric polar order by the micro polar regions appearing at the same temperature region. The present new system is expected to be a promising candidate for Pb-free ferroelectric materials.

Effects of B-site Ta5+ substitution on the ferroelectric transition and crystal structure modulation were investigated for Sr2Na(Nb1−xTax)5O15 (x = 0–0.5) tungsten bronzes. The weakened ferroelectricity and enhanced relaxor behaviors were observed with increasing Ta, while the room temperature crystal structure changed from non-centrosymmetric to centrosymmetric. Raman spectra showed a decreasing intensity of the internal vibrations with increasing Ta, revealing different bonding mechanisms between Nb/Ta cations and O anions with reduced covalence by Ta-substitution, which resulted in weakened polarization. Two sets of superlattice reflections were detected in the selected area electron diffraction patterns: commensurate modulation for all compositions (type I), described by the wave vectors q 1 = 1 4 ( a 0 ∗ + b 0 ∗ ) + 1 2 c 0 ∗ and q 2 = 1 2 ( a 0 ∗ + b 0 ∗ ); extra reflections of 1/2[0 0 l] at some local areas for Ta-containing compositions (type II), indicating the possible ordering of B-site cations. The distinct bonding state between the B-site cation and the O anion dominates the crossover from ferroelectric to relaxor behaviors in the present compounds.

Pinched P–E hysteresis loops have been observed in filled tungsten bronze Ba4Eu2Ti4Nb6O30, indicating the presence of novel polarization mechanisms. We investigate the evolution of polar order in filled tungsten bronze Ba4Eu2Ti4Nb6O30, together with its dielectric properties over a wide temperature range, from 50 K to 773 K. The temperature dependences of the dielectric properties exhibit two low-temperature dielectric relaxations, at around 300 K (P1), and 100 K (P2), and a high temperature peak at 588 K with no frequency dispersion, indicating the ferroelectric transition temperature T c. Pinched P–E loops are observed in the temperature range between the low temperature relaxation at P1, and the ferroelectric transition. On cooling, the pinched P–E hysteresis loops open gradually, with increasing remnant polarization (P r). Two pairs of reversal electric fields indicate two types of polar reversal mechanisms, with an activated energy of 1.41 eV (E 1), and 0.94 eV (E 2), respectively. One corresponds to the field-induced transition from a nonpolar to a polar state, which dominates at a high temperature close to T c, while the other relates to the reversal of ferroelectric domains which stabilize gradually on cooling. At temperatures below 300 K, the polarization exhibits an evident decrease, probably related to the disruption of the polar order due to the dielectric relaxation at P1.

In the present study, enhanced antiferromagnetic characteristics and room temperature magnetoelectric coupling are achieved by Fe-substitution for Mn in h-ScMnO3. The antiferromagnetic Neel temperature (TN) increases from 131 K for ScMnO3 up to 140 K for ScMn0.8Fe0.2O3. Electric field controlled magnetism is confirmed for ScMn0.8Fe0.2O3 at room temperature, combining with the short-range magnetic spin ordering. The Rietveld structural refinement and selected area electron diffraction confirm the noncentrosymmetric P63cm structure for the present ceramics. The ferroelectric domain walls at the atomic scale are determined by the aberration-corrected high-angle annular dark-field scanning transmission electron microscopy; meanwhile, the spontaneous polarization of 5.6 μC/cm2 is determined. The noticeable magnetoelectric coefficient αME ∼ 0.78 mV/cm Oe (measured under a magnetic field up to 3000 Oe) is obtained in ScMn0.8Fe0.2O3, which is quite stable with the applied magnetic field, reflecting coupling of the short-range spin ordering with the ferroelectric ordering. The enhanced antiferromagnetic behaviors are discussed with the effect of Fe-substitution, which reduce the magnetic frustration and enhance the exchange interaction.

In this study, the structure evidence of the Pna21 phase and the field-induced transition of Pna21/R3c have been quantitatively investigated in Bi1-xSmxFe0.99Ti0.01O3 (x = 0.12, 0.14, and 0.16) ceramics together with the subsequent electric field-controlled magnetism. A sequential phase transition of R3c-Pna21-Pbnm is detected by Rietveld refinement of the x-ray diffraction data. Further, the electric field-induced phase transition is investigated near the morphotropic phase boundary at x = 0.14, where the structure is tuned from Pna21 to R3c with poling treatment, and this transition could become reversible with as-annealing after poling. For x = 0.14, the structure is tuned from Pna21 to R3c with poling treatment, and this transition could become reversible with as-annealing after poling. The phase transition is confirmed by Rietveld refinements together with VSM measurements, providing an opportunity for electric field-controlled magnetism. The magnetoelectric coupling is enhanced, and the linear magnetoelectric coefficient αME up to 0.91 mV/Oe·cm is obtained in Bi1-xSmxFe0.99Ti0.01O3 ceramics. More importantly, the R3c and Pna21 structures are confirmed by selected area electron diffraction and dark-field analysis at x = 0.14, and the high-resolution TEM image demonstrates the coexistence of the R3c and Pna21 structures.

Ba 4 Pr 2 Fe 2 Nb 8 O 30 tungsten bronze ceramics have been prepared by a standard solid-state sintering method, and the electrical, dielectric and ferroelectric properties have been determined together with the structure. The structure dependence of ferroelectricity has been investigated by comparing the as-sintered, N 2 -annealed and O 2 -annealed samples. The typical relaxor ferroelectric nature is generally indicated in the present ceramics, where the broaden dielectric constant and dielectric loss peaks with strong frequency dispersion feature are observed. The peak temperatures for both dielectric constant and dielectric loss are significantly increased together with the much stronger frequency dispersion by N 2 -annealing, while the O 2 -annealing results in the decreased peak temperatures and the suppressed frequency dispersion. These phenomena are closely related to the valences of Fe and Pr ions. The hopping between Fe 2+ and Fe 3+ inside the grains causes the dielectric relaxation in as-sintered and N 2 -annealed samples. The enhanced ferroelectricity near room temperature is attributed to the increased ion radius difference between A1 and A2 ions because of the “substitution” Pr 4+ for Pr 3+ after N 2 -annealing.

Objective: To observe the effect of Atorvastatin intensive therapy on the serum inflammatory factors, platelet activity and fibrinolytic activity in patients with acute coronary syndrome (ACS). Methods: A total of 92 patients with ACS were randomly divided into observation group (47 cases) and control group (45 cases). The control group was given Atorvastatin (10mg/d) based on the conventional therapy, while the observation group was given Atorvastatin at an intensive dose (40 mg/d) based on the conventional therapy. Half a month later, the changes of IL-6, IL-8, hs-CRP, TNF-α, TXB2, GMP-140, PAI-1 and t-PA were observed and compared between the two groups. Results: After treatment, the inflammatory factors (IL-6, IL-8, hs-CRP and TNF-α) and the indicators of platelet activity (TXB2, GMP-140 and PAI-1) were obviously decreased, while the indicator of fibrinolytic activity (t-PA) was apparently increased in the two groups. Besides, the amplitudes of change referring to these indicators in the observation group were bigger than those in the control group after treatment, and the differences were statistically significant. Conclusion: The intensive therapy with the administration of Atorvastatin at a dose of 40 mg/d was better than the conventional therapy (Atorvastatin: 10 mg/d) in aspects of reducing inflammatory factors, inhibiting platelet activity and correcting the high coagulation state of fibrinolytic system.

The crossover from normal to relaxor ferroelectrics in Sr0.25Ba0.75(Nb1−xTax)2O6 (x = 0, 0.1, 0.25, and 0.5) ceramics was determined together with the structure evolution. A single-phase tungsten bronze structure in space group P4bm (x = 0 and 0.1) or P4/mbm (x = 0.25 and 0.5) was obtained in the entire composition range. The lattice parameter a increased, while c, tetragonality c/a, and cell volume decreased with increasing x. Meanwhile, the dielectric maximum temperature Tm went down and the dielectric peak exhibited an enhanced diffused nature with a stronger frequency dispersion, where the saturated P–E loop (x = 0 and 0.1) transformed to a slim relaxor loop (x = 0.25) and finally to the linear one (x = 0.5). Raman spectra results revealed the reduced covalence between the B-site cation and the oxygen ion as a result of Ta-substitution. The coexistence of Nb5+ and Ta5+, which possessed the distinct covalence with the oxygen ion, played the key role in the structural variation and crossover from normal to relaxor ferroelectrics in the present system.

Hybrid improper ferroelectricity (HIF) has received increasing scientific attention since it provides great potential for realizing single phase room temperature multiferroicity with strong magnetoelectric coupling, and Ruddlesden–Popper (R–P) compounds AO(ABO3)n with even n are the most important candidates for HIFs. However, the modulation of ferroelectric polarization is recognized as a challenging issue. Here, Sr3−xBaxSn2O7 ceramics with a large remanent polarization with respect to other R–P HIFs (∼1.0 μC/cm2) combined with a reduced coercive field are reported. The polarization increases obviously with the increasing tolerance factor, inconsistent with the previous understanding. This is because the amplitude of tilt increases and rotation decreases, which results in the increased distortion of SnO6 octahedra. That is, the polarization of R–P compounds should be determined by the combined effects of tilting and rotation and not be simply evaluated by the tolerance factor.

Te-based compounds are promising dielectric candidates for Base-Metal Electrode Multilayer Ceramic Capacitors (BME-MLCCs) and Low-Temperature Co-fired Ceramics (LTCCs) applications due to their low sintering temperature and good dielectric properties. In spite of the possible compatibility with Cu electrodes for microelectronics, data on compounds of the CuO-TeO2 system are scarce. Recently, we have reported the phase formation process of Cu3TeO6 and the first dielectric data for Cu3TeO6 ceramics. Due to the interest for some applications in thick films, in this work Cu3TeO6 thick films were fabricated by electrophoretic deposition (EPD) on platinized silicon substrates under different processing conditions. The relation between processing and film’s quality was established. ~ 50 μm Cu3TeO6 thick films sintered at 860 oC for 5 h exhibit a permittivity of ~2 and dielectric loss of 0.01 at room temperature and the temperature coefficient of the dielectric permittivity is 9.5×103 ppm°C-1 at 1 MHz from 40 °C to 120 °C. It is expected that this dielectric performance, when compared with the one of Cu3TeO6 ceramic counterparts, improves if the density of the films is increased.

Breast cancer greatly threatens the health of women all over the word despite of several effective drugs. Targeted therapy for breast cancer is limited to human epidermal growth factor receptor 2 (HER2). Herceptin®, monoclonal antibody against HER2, is now widely used in HER2(+) breast cancer. Abraxane®, the current gold standard for paclitaxel (PTX) delivery, has shown superiority in breast cancer based on nanoparticle albumin bound technology. Despite these advances, further novel targeted therapy with more improved anti-tumor efficacy for breast cancer is still urgently needed. Here, we report the recombinant nanocomposites (NPs) composed of the above two clinical drugs of Abraxane® and Herceptin® (Abra/anti-HER2), which at first migrates to the tumor region through the unique targeting mechanism of human serum albumin (HSA) of Abraxane®, and sequentially further precisely recognize the HER2(+) breast cancer cells due to Herceptin®. The Abra/anti-HER2 NPs were fabricated by a “one-step” synthesis using EDC/NHS. In vitro analysis of cell viability, apoptosis and cell cycle revealed that Abra/anti-HER2 NPs showed more anti-tumor efficacy against HER2(+) SK-BR-3 cells than Abraxane® at equivalent PTX concentration. In addition, in HER2(+) breast cancer xenograft model, Abra/anti-HER2 NPs significantly inhibited tumor growth with less side effects. Moreover, the properties of more precise target and delayed release of PTX were proved by NIRF imaging. Thus, our results indicate that Abra/anti-HER2 NPs could represent a next-generation sequentially dual-targeting therapeutic agent for HER2(+) breast cancer.

Sperm DNA damage is recognized as an important biomarker of male infertility. To investigate this, sperm DNA damage was assessed by the sperm chromatin dispersion (SCD) test in semen and motile spermatozoa harvested by combined density gradient centrifugation (DGC) and swim-up in 161 couples undergoing in vitro fertilization (IVF). Semen analysis and sperm DNA damage results were compared between couples who did or did not achieve pregnancy. The sperm DNA damage level was significantly different between the two groups (P < 0.05) and was negatively correlated with IVF outcomes. Logistic regression analysis confirmed that it was an independent predictor for achieving clinical pregnancy. The effects of different levels of sperm DNA damage on IVF outcomes were also compared. There were significant differences in day 3 embryo quality, blastocyst formation rate, and implantation and pregnancy rates (P < 0.05), but not in the basic fertilization rate between the two groups. Thus, sperm DNA damage as measured by the SCD appears useful for predicting the clinical pregnancy rate following IVF.

The experiment by iron ore tailings as the main raw material, add a small amount of fly ash, coal gangue, limestone and biological admixture, the preparation of iron ore tailings bio-ceramic filter material. The effect of the material proportion and sintering temperature and the ball size on the bio-ceramic filter material processing sewage pollutant removal efficiency was investigated. Research shows that the optimal proportion of bio-ceramic is: 86%iron ore tailings, 6% coal gangue, 4% fly ash, 3% limestone, 1% biological admixture. Under the condition of sintering temperature 1100 °C, bio-ceramic size 3 ~ 5 mm, the bio-ceramic filter material of COD removal efficiency 80% and turbidity of sewage 71% respectively. Through bio-ceramic filter material further analysis of XRD and SEM, in the sintering process of minerals such as sodium feldspar, quartz, hematite, together, make bio-ceramic has high strength. Internal porous bio-ceramic surface is rough at the same time, and the specific surface area is larger. Bio-ceramic has good adsorption performance, therefore, is helpful to remove the pollutant in the domestic sewage.

Novel three-dimensional (3D) hybrid materials, i.e., free-standing 3D graphene-supported MnO2 nanosheets, are prepared by a simple and controllable solution-phase assembly process. Characterization results show that MnO2 nanosheets are uniformly anchored on a 3D graphene framework with strong adhesion and the integral hybrids show desirable mechanical strength. Such unique structure of 3D graphene/MnO2 hybrids thus provides the right characteristics of binder-free electrode materials and could enable the design of different kinds of high-performance energy storage devices. Especially, an advanced asymmetric supercapacitor is built by using a 3D graphene/MnO2 hybrid and a 3D graphene as two electrodes, and it is able to work reversibly in a full operation voltage region of 0-3.5 V in an ionic liquid electrolyte and thus exhibits a high energy density of 68.4 Wh/kg. As the cathode materials for Li-O2 and Li-MnO2 batteries, the 3D graphene/MnO2 hybrids exhibit outstanding performances, including good catalytic capability, high reversible capacity and desirable cycling stability. The results presented here may pave a way for new promising applications of such 3D graphene/MnO2 hybrids in advanced electrochemical energy storage devices.

The role of cetuximab in treatment-related hematologic toxicity is not clear. We performed a meta-analysis of published randomized controlled trials (RCTs) to determine the overall risk of ≥grade 3 hematologic toxicity events (HTEs) associated with cetuximab. PubMed, EMBASE, and Web of Knowledge databases as well as abstracts presented at American Society of Clinical Oncology conferences and ClinicalTrials.gov were searched to identify relevant studies. Eligible studies included RCTs in which cetuximab in combination with chemotherapy or chemoradiotherapy was compared with chemotherapy or chemoradiotherapy alone. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using fixed- or random-effects models. A total of 11,234 patients with a variety of advanced solid tumors from 18 RCTs were included in the meta-analysis. Compared with chemotherapy alone, the addition of cetuximab was associated with increased risks of ≥grade 3 leucopenia/neutropenia and anemia events in colorectal cancer, with RRs of 1.16 (95% CI 1.05-1.27, p=0.002; incidence, 21.0 vs. 18.0%) and 2.67 (95% CI 1.53-4.65, p=0.01; incidence, 4.0 vs. 2.0%), respectively. Cetuximab was also associated with an increased risk of leucopenia/neutropenia in nonsmall cell lung cancer (NSCLC) (RR: 1.15; 95% CI 1.08-1.22, p

In this paper, activated carbons (ACs) with high specific surface areas were successfully synthesized by simple one-step carbonization-activation from paulownia sawdust biomass, and the effects of the synthetic conditions on their CO 2 capture capacity were investigated as well. The results show that, when the mass ratio between activator and biomass is 4, the activation temperature is 700 ℃ and the activation time is 1 h, as-made AC provides the most micropores for CO 2 adsorption. As a consequence, the maximum CO 2 uptake of 8.0 mmol/g is obtained at 0 ℃ and 1 bar.

Through the study, we found computer has powerful ability to analyze management in the colorful painting field.Spread of the mobile terminal augmented reality is a hot field in today's society technology development, composite is a new kind of create immersive virtual scene technology. Introduced the advantages of mobile terminal transmission of augmented reality and real life, the application of augmented reality and the mobile terminal transmission is discussed.

A comprehensive review on the latest development of the ferroelectric transition and low-temperature dielectric relaxations of filled tungsten bronze ceramics are presented together with some new issues. In the filled tungsten bronze ceramics M6−pRpTi2+pNb8−pO30 (p = 1, 2; M = Ba or Sr; R = rare earth or Bi), a ferroelectric transition is generally indicated together with up to three low-temperature dielectric relaxations. The ferroelectric transition is determined as 4/mmm → 4 mm, and the low-temperature dielectric relaxations are deeply concerned with the structure modulations due to the order/disorder of ions in A1 and A2 sites, their random cross occupancy, and the order/disorder of B-site ions. Both the ferroelectric transition and low-temperature dielectric relaxations are dominated by the composition and radius difference between A1- and A2-site ions, ∆r. The normal ferroelectric transition might be expected if the ratio of the biggest ion and second big ion is 2:1, otherwise the diffuse or relaxor ferroelectric is expected. Meanwhile, the larger ∆r generally results in the normal ferroelectric, and the smaller ∆r will lead to the diffuse or relaxor ferroelectric. Moreover, the effects of A sites order/disorder and the random cross occupancy of A-site ions are primary, and the effects of B-site ordering/disordering are secondary. The right ratio of 2:1 for A2- and A1-site ions and the large ∆r should be the guidelines for designing the possible multiferroic tungsten bronzes.

Recently, hexagonal rare earth ferrites (h-RFeO3) have attracted much scientific attention due to their room-temperature multiferroicity. The primary issue for h-RFeO3 is how to manipulate from nonpolar orthorhombic (Pbnm) structure to polar hexagonal (P63cm) structure, and this could be realized by the wet-chemical method, epitaxial stain engineering, or introducing chemical pressure. Another key issue for h-RFeO3 is the experimental determination of its macroferroelectricity and magnetoelectric (ME) coupling because the semiconducting nature seriously obstructs the experimental characterization. In the present work, owing to the suppressed leakage current density with decreasing temperature, saturated electrical hysteresis loops were observed in A-site substituted h-Lu0.5In0.5FeO3 ceramics at 198 K, directly demonstrating the presence of the macroferroelectricity. Room-temperature switchable ferroelectric polarization was further confirmed by the piezoresponse force microscopy. Furthermore, noticeable ME coupling with a linear ME voltage coefficient of 0.67 mV/cm Oe was observed at room temperature.

The aging effect and the metastable ferroelectric state are investigated in the Ba4Eu2(Ti0.9Zr0.1)4Ta6O30 ceramic, where the tetragonal tungsten bronze structure with a P4bm space group is confirmed. When the compound is cooled from temperatures far above its transition temperature (TC), a very slim polarization-electric field curve is observed at 300 K. After 3 days of aging at 300 K, an obvious increase in the remanent polarization and the coercive electric field can be obtained. Moreover, a gradual recovery of the endothermic peak is detected in the differential scanning calorimeter curves when the compound is cooled from temperatures above TC and aged at 300 K for several days. These phenomena are interpreted as the result of a metastable ferroelectric state and the related aging effect, which may be deeply concerned with the compositional inhomogeneity and the hindered superstructure transformation. Through manipulating A and B site cation substitutions, the range of the metastable ferroelectric state can be tuned, and compounds with a different ferroelectric transition process can be obtained.