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Your search keyword '"Xiao, Wei-Lie"' showing total 812 results
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812 results on '"Xiao, Wei-Lie"'

51. A pair of new oxindole alkaloids isolated from Uncaria macrophylla.

Author

Liang, Xin-Xin, Yang, Jin-Xuan, Li, Jian-Mei, Huang, Jia-Bi, Yang, Liu-Meng, Sun, Tian-Tian, Luo, Rong-Hua, Xiao, Wei-Lie, Zheng, Yong-Tang, and Li, Xiao-Li

Subjects
ALKALOIDS
Abstract

A pair of new oxindole alkaloids, named macrophyllines C (1) and D (2), together with two known oxindole alkaloids isorhynchophylline (3) and corynoxine (4) were isolated from Uncaria macrophylla. Their structures were elucidated based on detailed spectroscopic analysis and by comparison with literature data. In addition, all the isolates were tested for their anti-HIV activities and cytotoxicities in C8166 cells and compounds 2–4 showed weak anti-HIV activities with EC50 values of 11.31 ± 3.29 μM, 18.77 ± 6.14 μM and 30.02 ± 3.73 μM, respectively. [ABSTRACT FROM AUTHOR]

Published
2023
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52. Ainslides A−F, Six Sesquiterpenoids Isolated from Ainsliaea pertyoides and Their NLRP3‐Inflammasome Inhibitory Activity

Author

Zhang, Jing‐Jing, primary, Xu, Yao‐Jun, additional, Li, Rui, additional, Zhang, Yu, additional, Yue, Chen‐Fang, additional, Bi, De‐Wen, additional, Cheng, Bin, additional, Wu, Xue‐Wen, additional, Zhang, Rui‐Han, additional, Zhang, Xing‐Jie, additional, Li, Xiao‐Li, additional, and Xiao, Wei‐Lie, additional

Published
2022
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54. Triterpene constituents from the fruits of Cyclocarya paliurus and their anti-HIV-1IIIB activity

Author

Tu, Wen-Chao, Luo, Rong-Hua, Yuan, En, Sakah, Kaunda-Joseph, Yang, Quan-Yu, Xiao, Wei-Lie, Zheng, Yong-Tang, and Liu, Mei-Feng

Subjects
Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry
Abstract

Four new norceanothane-type triterpenes, cyclopalin A-D (1-4), and sixteen known compounds (5-20) were obtained from the fruits of Cyclocarya paliurus. Their structures were determined by spectroscopic data, experimental electronic circular dichroism (ECD) and X-ray single crystal analyses. All isolated compounds were assayed for their anti-HIV-1IIIB activity. Compound 18 exhibited potent anti-HIV-1IIIB activity with an EC50 value of 1.32 μM (SI = 151.52).

Published
2022
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55. Two new compounds from Verbena bonariensis

Author

Li, Rui, Chen, Yuan-Si, Bi, De-Wen, Wei, Qiong, Zhou, Ya-Ling, Qiu, Xiong, Zhang, Rui-Han, Zhang, Xing-Jie, Xiao, Wei-Lie, Li, Hong-Liang, and Li, Xiao-Li

Subjects
Pharmacology, Complementary and alternative medicine, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, General Medicine, Analytical Chemistry
Abstract

Two new compounds verboncin A (1) and verboncin B (4) and 14 known compounds (2–3 and 5–16) were isolated from Verbena bonariensis, and these 14 compounds were first obtained from this plant. Their chemical structures were established by one and two-dimensional NMR and HRESIMS analysis and the results were compared with literature values. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD). The cytotoxicity of some of the compounds against MCF-7, HCT-116, MDA-MB-231, and SW620 human cancer cell lines were evaluated, in which compound 4 showed negligible cytotoxic activity with an IC50 value of 68.08 ± 0.35 µM against the MCF-7 cell line.

Published
2022
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64. Euphzycopias A−I, macrocyclic diterpenes with NLRP3 inflammasome inhibitory activity from Euphorbia helioscopia L.

Author

Zhang, Yu, primary, Xiong, Feng, additional, Zhang, Jing-Jing, additional, Yue, Chen-Fang, additional, Bi, De-Wen, additional, Cheng, Bin, additional, Wu, Xue-Wen, additional, Li, Qing, additional, Zhang, Xing-Jie, additional, Zhang, Rui-Han, additional, Dai, Xiao-Chang, additional, Shi, Qiang-Qiang, additional, Xiao, Wei-Lie, additional, and Li, Xiao-Li, additional

Published
2022
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65. Strophioblachins A–K, Structurally Intriguing Diterpenoids from Strophioblachia fimbricalyxwith Potential Anticardiac Hypertrophic Inhibitory Activity

Author

Qiu, Xiong, Huang, Yong-Xiang, Yuan, Jing, Zu, Xue-Dan, Zhou, Ya-Ling, Li, Rui, Wu, Ze-Kai, Xiao, Wei-Lie, Zheng, Chang-Bo, and Li, Xiao-Li

Abstract

Three new rearranged diterpenoids, strophioblachins A–C (1–3), eight new diterpenoids, strophioblachins D–K (4–11), and seven previously described diterpenoids (12–18) were purified from the aerial parts of Strophioblachia fimbricalyx.Compounds 1and 2contain a rare 6/6/5/6 ring system, while 3has an uncommon tricyclo[4.4.0.08,9]tridecane-bridged unit, and their diterpenoid skeletons are being reported for the first time. Utilizing spectroscopic and HRESIMS data analysis, the structures of the new compounds (1–11) were established, and ECD and 13C NMR calculations were used to confirm the relative and absolute configurations of 11and 9. The absolute configurations of compounds 1, 3, and 10were established using single-crystal X-ray diffraction. The results of testing for anticardiac hypertrophic activity demonstrated that compounds 10and 15dose-dependently lowered the mRNA expression of Nppaand Nppb. Protein levels were confirmed by Western blotting, which also demonstrated that compounds 10and 15lowered the expression of the hypertrophic marker ANP. The cytotoxic activity against neonatal rat cardiomyocytes was assayed in vitro by the CCK-8 and ELISA methods, and the results showed that compounds 10and 15were only very weakly active in the range.

Published
2023
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80. A pair of new oxindole alkaloids isolated from Uncaria macrophylla

Author

Liang, Xin-Xin, Yang, Jin-Xuan, Li, Jian-Mei, Huang, Jia-Bi, Yang, Liu-Meng, Sun, Tian-Tian, Luo, Rong-Hua, Xiao, Wei-Lie, Zheng, Yong-Tang, and Li, Xiao-Li

Abstract

A pair of new oxindole alkaloids, named macrophyllines C (1) and D (2), together with two known oxindole alkaloids isorhynchophylline (3) and corynoxine (4) were isolated from Uncaria macrophylla. Their structures were elucidated based on detailed spectroscopic analysis and by comparison with literature data. In addition, all the isolates were tested for their anti-HIV activities and cytotoxicities in C8166 cells and compounds 2���4 showed weak anti-HIV activities with EC50 values of 11.31 �� 3.29 ��M, 18.77 �� 6.14 ��M and 30.02 �� 3.73 ��M, respectively.

Published
2021
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81. Centrantheroside F, a new ionone glycoside from Centranthera grandiflora.

Author

Liang, Xin-Xin, Li, Qi, Li, Hui-Juan, Ning, Yan-Mei, Zhang, Rui-Han, Zhang, Xing-Jie, Li, Xiao-Li, and Xiao, Wei-Lie

Subjects
EXPERIMENTAL design, HIGH performance liquid chromatography, GLYCOSIDES, NUCLEAR magnetic resonance spectroscopy, PLANT roots, DESCRIPTIVE statistics, RESEARCH funding, PLANT extracts, NITRIC oxide, MOLECULAR structure, SPECTRUM analysis
Abstract

One new ionone glycoside, named centrantheroside F (1), together with 9 known compounds (2-10), were isolated from the roots of Centranthera grandiflora. Their structures were determined by spectroscopic data analyses and comparing with the literature data. The absolute configuration of 1 was confirmed via 2 D NMR and electronic circular dichroism (ECD). All isolated compounds were evaluated for their inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide (NO) production. [ABSTRACT FROM AUTHOR]

Published
2022
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94. Callintegers A and B, Unusual Tricyclo[4.4.0.09,10]tetradecane Clerodane Diterpenoids from Callicarpa integerrimawith Inhibitory Effects on NLRP3 Inflammasome Activation

Author

Bi, De-Wen, Xiong, Feng, Cheng, Bin, Zhou, Ya-Ling, Zeb, Muhammad Aurang, Tang, Peng, Pang, Wen-Hui, Zhang, Rui-Han, Li, Xiao-Li, Zhang, Xing-Jie, and Xiao, Wei-Lie

Abstract

Callintegers A (1) and B (2), unprecedented clerodane norditerpenoids based on a novel carbon skeleton, were isolated from Callicarpa integerrima. Compounds 1and 2possess a novel 6/6/6-fused tricyclic ring system. Their structures and absolute configurations were determined by quantum chemical calculations, spectroscopic analysis, and single-crystal X-ray diffraction methods. Biological evaluation showed that compound 2inhibited IL-1β secretion in a dose-dependent manner with an IC50value of 5.5 ± 3.2 μM. Caspase-1 maturation and IL-1β secretion were also reduced, indicating that compound 2impaired NLRP3 inflammasome activation.

Published
2022
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96. Correction to “Rubriflordilactones A and B, Two Novel Bisnortriterpenoids from Schisandra rubriflora and Their Biological Activities”

Author

Xiao, Wei-Lie, primary, Yang, Liu-Meng, additional, Gong, Ning-Bo, additional, Wu, Li, additional, Wang, Rui-Rui, additional, Pu, Jian-Xin, additional, Li, Xiao-Li, additional, Huang, Sheng-Xiong, additional, Zheng, Yong-Tang, additional, Li, Rong-Tao, additional, Lu, Yang, additional, Zheng, Qi-Tai, additional, and Sun, Han-Dong, additional

Published
2021
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99. Rubellawus A–D, Four New Diterpenoids Isolated from Callicarpa rubella and Their Anti‐NLRP3 Inflammasome Effects

Author

Wu, Xue‐Wen, primary, Wang, Qi, additional, Li, Qing, additional, Cui, Yi‐Man, additional, Pu, Yu‐Kun, additional, Shi, Qiang‐Qiang, additional, Bi, De‐Wen, additional, Zhang, Jing‐Jing, additional, Zhang, Rui‐Han, additional, Li, Xiao‐Li, additional, Zhang, Xing‐Jie, additional, and Xiao, Wei‐Lie, additional

Published
2020
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