51. miR-27a promotes cell proliferation and metastasis in renal cell carcinoma.
- Author
-
Peng H, Wang X, Zhang P, Sun T, Ren X, and Xia Z
- Subjects
- Carcinoma, Renal Cell genetics, Carcinoma, Renal Cell pathology, Cell Line, Tumor, Cell Movement genetics, Female, Gene Expression Regulation, Neoplastic, Humans, Kidney Neoplasms genetics, Kidney Neoplasms pathology, Male, MicroRNAs genetics, Middle Aged, Neoplasm Metastasis pathology, Prognosis, Up-Regulation, Carcinoma, Renal Cell metabolism, Cell Proliferation genetics, Kidney Neoplasms metabolism, MicroRNAs metabolism, Neoplasm Metastasis genetics
- Abstract
miR-27a has been reported to exhibit abnormal expression in renal cell carcinoma (RCC), but the role of miR-27a in RCC remains unknown. In our study, up-regulation of miR-27a was validated by Real-time PCR analysis in 133 RCC samples. Overexpression of miR-27a promoted cell migration, invasion and proliferation in vitro, while its low expression exerted opposite effects. Kaplan-Meier analysis demonstrated that the patients with high expression of miR-27a had a worse overall and relapse-free survivals compared with those with low expression of miR-27a. Cox proportional hazards analyses showed that miR-27a expression was an independent prognostic factor for RCC patients. Collectively, our findings illustrate the promoting-cancer effect of miR-27a in RCC, suggesting that miR-27a could be a potential therapeutic target for RCC. Additionally, Kaplan-Meier analyses and Cox proportional regression analysis suggest that miR-27a may be a potential biomarker for predicting the survival of RCC patients.
- Published
- 2015