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56. Epigenetic therapy inhibits metastases by disrupting premetastatic niches

Author

Lu, Zhihao, Zou, Jianling, Li, Shuang, Topper, Michael J., Tao, Yong, Zhang, Hao, Jiao, Xi, Xie, Wenbing, Kong, Xiangqian, Vaz, Michelle, Li, Huili, Cai, Yi, Xia, Limin, Huang, Peng, Rodgers, Kristen, Lee, Beverly, Riemer, Joanne B., Day, Chi-Ping, Yen, Ray-Whay Chiu, Cui, Ying, Wang, Yujiao, Wang, Yanni, Zhang, Weiqiang, Easwaran, Hariharan, Hulbert, Alicia, Kim, KiBem, Juergens, Rosalyn A., Yang, Stephen C., Battafarano, Richard J., Bush, Errol L., Broderick, Stephen R., Cattaneo, Stephen M., Brahmer, Julie R., Rudin, Charles M., Wrangle, John, Mei, Yuping, Kim, Young J., Zhang, Bin, Wang, Ken Kang-Hsin, Forde, Patrick M., Margolick, Joseph B., Nelkin, Barry D., Zahnow, Cynthia A., Pardoll, Drew M., Housseau, Franck, Baylin, Stephen B., Shen, Lin, and Brock, Malcolm V.

Published
2020
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59. SRSF10 inhibition prevents HCC growth and metastasis and enhances the anti-PD-L1- mediated tumor suppression

Author

Luo, Xiangyuan, primary, Zhang, Zerui, additional, Wang, Yijun, additional, Sun, Mengyu, additional, Hu, Dian, additional, Jiang, Junqing, additional, Wang, Yufei, additional, Ji, Xiaoyu, additional, Chen, Xiaoping, additional, Zhang, Bixiang, additional, Liang, Huifang, additional, Li, Yiwei, additional, Liu, Bifeng, additional, Nie, Yongzhan, additional, Wu, Kaichun, additional, Fan, Daiming, additional, Liu, Danfei, additional, Huang, Wenjie, additional, and Xia, Limin, additional

Published
2023
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71. Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+T cell-mediated antitumour immunity and improves anti-PD-1 efficacy

Author

Cai, Ning, Cheng, Kun, Ma, Yue, Liu, Sha, Tao, Ran, Li, Yani, Li, Danfeng, Guo, Bin, Jia, Wenlong, Liang, Huifang, Zhao, Jianping, Xia, Limin, Ding, Ze-yang, Chen, Jinhong, and Zhang, Wanguang

Abstract

ObjectiveThe gain of function (GOF) CTNNB1 mutations (CTNNB1GOF) in hepatocellular carcinoma (HCC) cause significant immune escape and resistance to anti-PD-1. Here, we aimed to investigate the mechanism of CTNNB1GOFHCC-mediated immune escape and raise a new therapeutic strategy to enhance anti-PD-1 efficacy in HCC.DesignRNA sequencing was performed to identify the key downstream genes of CTNNB1GOFassociated with immune escape. An in vitro coculture system, murine subcutaneous or orthotopic models, spontaneously tumourigenic models in conditional gene-knock-out mice and flow cytometry were used to explore the biological function of matrix metallopeptidase 9 (MMP9) in tumour progression and immune escape. Single-cell RNA sequencing and proteomics were used to gain insight into the underlying mechanisms of MMP9.ResultsMMP9 was significantly upregulated in CTNNB1GOFHCC. MMP9 suppressed infiltration and cytotoxicity of CD8+T cells, which was critical for CTNNB1GOFto drive the suppressive tumour immune microenvironment (TIME) and anti-PD-1 resistance. Mechanistically, CTNNB1GOFdownregulated sirtuin 2 (SIRT2), resulting in promotion of β-catenin/lysine demethylase 4D (KDM4D) complex formation that fostered the transcriptional activation of MMP9. The secretion of MMP9 from HCC mediated slingshot protein phosphatase 1 (SSH1) shedding from CD8+T cells, leading to the inhibition of C-X-C motif chemokine receptor 3 (CXCR3)-mediated intracellular of G protein-coupled receptors signalling. Additionally, MMP9 blockade remodelled the TIME and potentiated the sensitivity of anti-PD-1 therapy in HCC.ConclusionsCTNNB1GOFinduces a suppressive TIME by activating secretion of MMP9. Targeting MMP9 reshapes TIME and potentiates anti-PD-1 efficacy in CTNNB1GOFHCC.

Published
2024
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73. Supplementary Video 8 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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74. Supplementary Table 1 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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75. Supplementary Methods from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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76. Supplementary Video 6 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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77. Data from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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78. Supplementary Video 3 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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79. Supplementary Video 2 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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80. Supplementary Table 3 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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81. Supplementary Video 7 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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82. Supplementary Video 5 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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83. Supplementary Figure 5 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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84. Supplementary Figure 6 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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85. Supplementary Figure 3 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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86. Supplementary Figure 4 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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87. Supplementary Figure 1 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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88. Supplementary Table 4 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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89. Supplementary Video 1 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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90. Supplementary Table 2 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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91. Supplementary Video 4 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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92. Supplementary Figure 2 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, primary, Jeong, Yea Ji, primary, Chianchiano, Peter, primary, Xia, Limin, primary, Luchini, Claudio, primary, Veronese, Nicola, primary, Dowiak, Cameron, primary, Ng, Tammy, primary, Trujillo, Maria A., primary, Huang, Bo, primary, Pflüger, Michael J., primary, Macgregor-Das, Anne M., primary, Lionheart, Gemma, primary, Jones, Danielle, primary, Fujikura, Kohei, primary, Nguyen-Ngoc, Kim-Vy, primary, Neumann, Neil M., primary, Groot, Vincent P., primary, Hasanain, Alina, primary, van Oosten, A. Floortje, primary, Fischer, Sandra E., primary, Gallinger, Steven, primary, Singhi, Aatur D., primary, Zureikat, Amer H., primary, Brand, Randall E., primary, Gaida, Matthias M., primary, Heinrich, Stefan, primary, Burkhart, Richard A., primary, He, Jin, primary, Wolfgang, Christopher L., primary, Goggins, Michael G., primary, Thompson, Elizabeth D., primary, Roberts, Nicholas J., primary, Ewald, Andrew J., primary, and Wood, Laura D., primary

Published
2023
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93. An integrative analysis revealing cuproptosis-related lncRNAs signature as a novel prognostic biomarker in hepatocellular carcinoma

Author

Chen, Xilang, primary, Sun, Mengyu, additional, Feng, Weibo, additional, Chen, Jie, additional, Ji, Xiaoyu, additional, Xie, Meng, additional, Huang, Wenjie, additional, Chen, Xiaoping, additional, Zhang, Bixiang, additional, Nie, Yongzhan, additional, Fan, Daiming, additional, Wu, Kaichun, additional, and Xia, Limin, additional

Published
2023
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97. HMGB1-mediated elevation of KLF7 facilitates hepatocellular carcinoma progression and metastasis through upregulating TLR4 and PTK2

Author

Feng, Weibo, primary, Chen, Jie, additional, Huang, Wenjie, additional, Wang, Guodong, additional, Chen, Xilang, additional, Duan, Lili, additional, Yin, Yue, additional, Chen, Xiaoping, additional, Zhang, Bixiang, additional, Sun, Mengyu, additional, Luo, Xiangyuan, additional, Nie, Yongzhan, additional, Fan, Daiming, additional, Wu, Kaichun, additional, and Xia, Limin, additional

Published
2023
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100. Characterization of the substernal space with computed tomography imaging in patients with and without median sternotomy: Assessing a novel implant location for extravascular defibrillation lead placement.

Author

Chen, Wanlan, Gong, Yongjun, Xia, Limin, Zhang, Yu, Lu, Hongyang, Bhatia, Varun, Thompson, Amy, Cao, Jian, Yang, Jun, Yao, Weiwu, and Qiu, Zhaohui

Subjects
STERNUM surgery, HEART anatomy, ANALYSIS of variance, STERNUM, THORACIC surgery, IMPLANTABLE cardioverter-defibrillators, RETROSPECTIVE studies, ELECTROCARDIOGRAPHY, DESCRIPTIVE statistics, RESEARCH funding, COMPUTED tomography, BODY mass index
Abstract

Background: Implantable cardioverter‐defibrillators (ICDs) provide clinically significant therapy for the prevention of sudden cardiac death. This study aimed to characterize the substernal space using computed tomography (CT) in patients with and without prior midline sternotomy to investigate the feasibility of substernal ICD lead implantation in post‐sternotomy patients. Methods: High‐quality electrocardiogram‐gated CT images from 100 patients (71% male, average body mass index 23.5 ± 2.9) were retrospectively collected, including 50 patients with prior midline sternotomy (S‐group) and 50 patients with no prior sternotomy (NS‐group). Distances were measured from the retrosternal surface to the epicardial surface of the heart and segmented into four regions from the xiphoid tip and superiorly along the sternum. Results: Results generally showed a measurable but narrower average sternum‐to‐heart distance in the prior sternotomy group compared to the non‐sternotomy group in all four regions (p <.05). In the S‐group, the sternum‐to‐heart distances across all regions ranged from 0 to 32.0 mm, while in the NS‐group, the distances ranged from 0 to 39.9 mm. Conclusion: Small but measurable separations between the heart and sternum were observed in patients with prior sternotomy, particularly near the xiphoid region, indicating the potential viability of extravascular substernal ICD lead implantation in post‐sternotomy patients. [ABSTRACT FROM AUTHOR]

Published
2023
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