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1,546 results on '"XU Haibo"'

52. TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh

Author

Zhao, Limin, Ke, Hao, Xu, Haibo, Wang, Guo-Dong, Zhang, Honglei, Zou, Li, Xiang, Shu, Li, Mengyuan, Peng, Li, Zhou, Mingfang, Li, Lingling, Ao, Lei, Yang, Qin, Shen, Che-Kun James, Yi, Ping, Wang, Lu, and Jiao, Baowei

Subjects
Genetics, Nutrition, Clinical Research, 1.1 Normal biological development and functioning, Underpinning research, Animals, Breast, Butyrophilins, DNA-Binding Proteins, Epithelial Cells, Female, Gene Expression Regulation, Humans, Lactation, Lactation Disorders, Lipid Droplets, Lipids, Mammary Glands, Animal, Mice, Mice, Knockout, Milk, RNA, Messenger, Transcriptome, Xanthine Dehydrogenase
Abstract

Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. However, the underlying molecular mechanism is less clear. Here we report that TDP-43, a RNA-binding protein, underwent positive selection in the mammalian lineage. Furthermore, TDP-43 gene (Tardbp) loss induces accumulation of large lipid droplets and severe lipid secretion deficiency in mammary epithelial cells to outside alveolar lumens, eventually resulting in lactation failure and pup starvation within three weeks postpartum. In human milk samples from lactating women, the expression levels of TDP-43 is positively correlated with higher milk output. Mechanistically, TDP-43 exerts post-transcriptional regulation of Btn1a1 and Xdh mRNA stability, which are required for the secretion of lipid droplets from epithelial cells to the lumen. Taken together, our results highlights the critical role of TDP-43 in milk lipid secretion, providing a potential strategy for the screening and intervention of clinical lactation insufficiency.

Published
2020

54. Distinct glutamatergic projections of the posteroventral medial amygdala play different roles in arousal and anxiety

Author

Li, Ying, primary, Deng, Yuchen, additional, Zhang, Yifei, additional, Xu, Dan, additional, Zhang, Xuefen, additional, Li, Yue, additional, Li, Yidan, additional, Chen, Ming, additional, Wang, Yuxin, additional, Zhang, Jiyan, additional, Wang, Like, additional, Cang, Yufeng, additional, Cao, Peng, additional, Bi, Linlin, additional, and Xu, Haibo, additional

Published
2024
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56. Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis

Author

Ming, Tianqi, primary, Lei, Jiarong, additional, Peng, Yuhui, additional, Wang, Minmin, additional, Liang, Yuanjing, additional, Tang, Shun, additional, Tao, Qiu, additional, Wang, Muqing, additional, Tang, Xiaomeng, additional, He, Ziyu, additional, Liu, Xiaohong, additional, and Xu, Haibo, additional

Published
2024
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72. STAGE as a multicenter, multivendor protocol for imaging Parkinson’s disease: a validation study on healthy controls

Author

He, Naying, Wu, Bo, Liu, Yu, Zhang, Chunyan, Cheng, Jingliang, Gao, Bingbing, Miao, Yanwei, Wu, Wenjun, Wang, Lixia, Sun, Rongqing, Sun, Wenbo, Xu, Haibo, Bai, Yan, Wang, Meiyun, Chai, Chao, Xia, Shuang, Zheng, Qiao, Li, Yongmei, Qin, Yan, Liao, Weihua, Chen, Yongsheng, Jokar, Mojtaba, Wang, Ying, Yan, Fuhua, and Haacke, E. Mark

Published
2022
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80. Study design of deep learning based automatic detection of cerebrovascular diseases on medical imaging: a position paper from Chinese Association of Radiologists

Author

Zhang, Longjiang, Shi, Zhao, Chen, Min, Chen, Yingmin, Cheng, Jingliang, Fan, Li, Hong, Nan, Jia, Wenxiao, Jiang, Guihua, Ju, Shenghong, Li, Xiaogang, Li, Xiuli, Liang, Changhong, Liao, Weihua, Liu, Shiyuan, Lu, Zaiming, Ma, Lin, Ren, Ke, Rong, Pengfei, Song, Bin, Sun, Gang, Wang, Rongpin, Wen, Zhibo, Xu, Haibo, Xu, Kai, Yan, Fuhua, Yu, Yizhou, Zha, Yunfei, Zhang, Fandong, Zheng, Minwen, Zhou, Zhen, Zhu, Wenzhen, Lu, Guangming, and Jin, Zhengyu

Published
2022
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81. Barriers and Facilitators to Coping with Second Victim Experiences: Insights from Nurses and Nurse Managers.

Author

Li, Xizhao, Chong, Mei-Chan, Che, Chong-Chin, Li, Yamin, Wang, Ling, Dong, Alan, Zhong, Ziqing, and Xu, Haibo

Subjects
WORK, CORPORATE culture, COMMUNITY support, NURSE administrators, RESEARCH funding, QUALITATIVE research, MEDICAL quality control, PATIENT safety, FRONTLINE nurses, WORK environment, INTERVIEWING, STATISTICAL sampling, RESEARCH evaluation, SCIENTIFIC observation, PSYCHOLOGICAL adaptation, JUDGMENT sampling, TERTIARY care, NURSING, DESCRIPTIVE statistics, THEMATIC analysis, EMOTIONAL trauma, NURSES' attitudes, RESEARCH methodology, JOB stress, ADVERSE health care events, DATA analysis software, FAMILY support, EXPERIENTIAL learning
Abstract

Background. Second victim experiences have long‐term impacts on the personal and professional well‐being of nurses. Individual‐centered support is necessary to help nurses cope with the various stages of the second victim experience. Objectives. To explore personal and workplace factors that facilitate or hinder coping styles for second victim experiences from the perspectives of both frontline nurses and nurse managers. Design. This was a descriptive qualitative study that incorporated semistructured interviews. Methods. Purposive sampling was employed to enlist a total of eight nurses and seven nurse managers selected from five tertiary hospitals located in Hunan Province, China. The study participants included nurses who had suffered second victim experiences and nurse managers who had grappled with their nurses' second victim experiences. The data were transcribed verbatim and analysed using thematic analysis. Results. The analysis revealed four main themes that influenced nurses' ability to cope with second victim experiences: source of emotional trauma, personal factors, job stress, and support system. In contrast, emotional trauma from patients and relatives, negative personal traits, shadows from the second victim experience, and unsupportive workplace environments were obstacles to coping with second victim experiences. Conclusion. The study highlights facilitators and barriers that nurses cope with second victim experiences, providing insight to develop targeted interventions that support nurses and mitigate the negative impacts of second victim experiences. A comprehensive approach is more effective in supporting nurses in coping with second victim experiences, improving patient safety, and enhancing the quality of care. [ABSTRACT FROM AUTHOR]

Published
2024
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83. Research on Internal Flow and Pressure Fluctuation Characteristics of Centrifugal Pumps as Turbines with Different Blade Wrap Angles.

Author

Xu, Haibo, An, Weizheng, Ke, Erqinhu, Ma, Yingyi, Geng, Linlin, Yang, Gang, and Zhang, Desheng

Subjects
CENTRIFUGAL pumps, PUMP turbines, TURBINE blades, TURBINE pumps, ANGLES, ENTROPY, IMPELLERS
Abstract

The use of pumps as turbines has been gaining more and more attention in recent years. The present work mainly investigates the influence of blade wrap angle on the internal flow and pressure fluctuation characteristics of centrifugal pumps as turbines. Five different wrap angles (35°,45°, 55°, 65°, and 75°) for a forward-curved impeller were numerically analyzed under multiple operating conditions. The accuracy of numerical simulation was validated by experimental results. The results show that maximum efficiency is achieved with a blade wrap angle of 35°, and the highest efficiency flow point gradually decreases as the blade wrap angle increases. It is found by conducting entropy production theory analysis that the high-entropy production rate regions in PATs are concentrated in the volute tongue and impeller blade inlet regions, and that the entropy production rate at the impeller inlet region increases and then decreases as the blade wrap angle decreases. In addition, pressure pulsation was affected not only by dynamic and static interference but also by an irregular vortex around the impeller; its magnitude under Qt is higher than 0.8Qt for blade wrap angles of 55° and 75°. The primary frequency of pressure pulsation within the impeller is the axial frequency fn and its multiples, and the frequency with the largest amplitude is 3fn. The periodicity of vortices is closely related to the periodicity of pressure pulsation. And it is suggested that a PAT with a 35° blade wrap angle is advantageous for improving the stability of a turbine. [ABSTRACT FROM AUTHOR]

Published
2024
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89. Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species

Author

Zhang, Xiao-Jing, Liu, Xiaolan, Hu, Manli, Zhao, Guo-Jun, Sun, Dating, Cheng, Xu, Xiang, Hui, Huang, Yong-Ping, Tian, Rui-Feng, Shen, Li-Jun, Ma, Jun-Peng, Wang, Hai-Ping, Tian, Song, Gan, Shanyu, Xu, Haibo, Liao, Rufang, Zou, Toujun, Ji, Yan-Xiao, Zhang, Peng, Cai, Jingjing, Wang, Zhao V., Meng, Guannan, Xu, Qingbo, Wang, Yibin, Ma, Xin-Liang, Liu, Peter P., Huang, Zan, Zhu, Lihua, She, Zhi-Gang, Zhang, Xin, Bai, Lan, Yang, Hailong, Lu, Zhibing, and Li, Hongliang

Published
2021
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92. Evaluation and Analysis of Intelligent Early Warning System in Crowded Places

Author

Wang, Qiquan, Liu, Meiming, Xu, Haibo, Meng, Yanhua, Chen, Ping, Zhu, Yu, Sun, Xi, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Long, Shengzhao, editor, and Dhillon, Balbir S., editor

Published
2020
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93. HVDC Commutation Failures Detection for Security and Stability Control Based on Local Electrical Quantities

Author

Liu, Dongyang, Li, Zhukun, Xu, Haibo, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martin, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Xue, Yusheng, editor, Zheng, Yuping, editor, and Rahman, Saifur, editor

Published
2020
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