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Your search keyword '"X. Y. Meng"' showing total 59 results
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59 results on '"X. Y. Meng"'

54. [Synthesis and antimalarial and antineoplastic activities of some derivatives of 2,4-diamino-5-methyl-6-substituted benzylaminoquinazolines]

Author

X Y, Meng, X P, Zhang, B S, Li, and G D, Li

Subjects
Antimalarials, Mice, Plasmodium berghei, Aminoquinolines, Tumor Cells, Cultured, Animals, Antineoplastic Agents, Leukemia L1210, Melanoma, Malaria
Abstract

This paper reports the synthesis and the antimalarial and anticancer activities of some derivatives of 2,4-diamino-5-methyl-6-substituted benzylaminoquinazolines. These compounds were synthesized by condensation of 5-methyl-2,4,6-triaminoquinazoline with substituted benzyaldehyde to produce Schiff base, followed by reduction, formylation or nitrosation. The suppressive therapeutic effects against Plasmodium berghei in mice showed that the suppressive rate of three compounds (IV 2,5,6)was 100 per cent at the dosage 5 mg/kg. The anticancer activity in vitro showed that II7 and IV3 had the strongest inhibition and their IC50 against L1210 Leukemia cell were 3.910 X 10(-3) micrograms/ml and 6.172 X 10(-3) micrograms/ml.

Published
1989

55. Sulphomucin colonic type intestinal metaplasia and carcinoma in the stomach. A histochemical study of 115 cases obtained by biopsy

Author

C B, Huang, J, Xu, J F, Huang, and X Y, Meng

Subjects
Metaplasia, Staining and Labeling, Colon, Gastric Mucosa, Histocytochemistry, Stomach Neoplasms, Biopsy, Gastritis, Carcinoma, Intestine, Small, Mucins, Humans, Intestinal Mucosa
Abstract

One hundred fifteen gastroscopic biopsy specimens (54 cases of carcinoma and 61 of gastritis) were used in this histochemical study. Intestinal metaplasia (IM) was classified into small intestinal type (ST) and colonic type (CT). The former may be a reactive change only. The incidence of sulphomucin colonic type (SCT) metaplasia was higher in gastric carcinomas than in benign lesions (P less than 0.01), and a relation between SCT metaplasia and cancer was demonstrated by both histologic and histochemical procedures. This suggests that SCT IM is correlated with certain precancerous lesions. There was no significant difference in the incidence of O-acetyl sialomucin colonic type (OCT) metaplasia between benign and malignant diseases. Further study is needed to determine why slightly more than half of the SCT IM was accompanied by OCT IM.

Published
1986

59. Eukaryotic translation elongation factor 1 alpha (eEF1A) inhibits Siniperca chuatsi rhabdovirus (SCRV) infection through two distinct mechanisms.

Author

Meng X-Y, Jiang Q-Q, Yu X-D, Zhang Q-Y, and Ke F

Subjects
Animals, Fishes, Viral Proteins genetics, Viral Proteins metabolism, Peptide Elongation Factor 1 genetics, Peptide Elongation Factor 1 metabolism, Rhabdoviridae physiology, Rhabdoviridae Infections metabolism, Rhabdoviridae Infections veterinary, Fish Proteins metabolism, Fish Diseases metabolism
Abstract

Importance: Although a virus can regulate many cellular responses to facilitate its replication by interacting with host proteins, the host can also restrict virus infection through these interactions. In the present study, we showed that the host eukaryotic translation elongation factor 1 alpha (eEF1A), an essential protein in the translation machinery, interacted with two proteins of a fish rhabdovirus, Siniperca chuatsi rhabdovirus (SCRV), and inhibited virus infection via two different mechanisms: (i) inhibiting the formation of crucial viral protein complexes required for virus transcription and replication and (ii) promoting the ubiquitin-proteasome degradation of viral protein. We also revealed the functional regions of eEF1A that are involved in the two processes. Such a host protein inhibiting a rhabdovirus infection in two ways is rarely reported. These findings provided new information for the interactions between host and fish rhabdovirus., Competing Interests: The authors declare no conflict of interest.

Published
2023
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