Search

Your search keyword '"X. X. Wu"' showing total 2,482 results
Start Over Author "X. X. Wu"
2,482 results on '"X. X. Wu"'

51. SYNTHESIS AND CHARACTERIZATON OF HIGH-QUALITY <font>GaN</font> NANORODS WITH TRIANGULAR CROSS SECTION

Author

Yi Yang, Yunkang Chen, Zhenghua Hu, X. X. Wu, Jijiang Fu, Yinong Lu, and Qiang Wu

Subjects
Photoluminescence, Materials science, business.industry, Statistical and Nonlinear Physics, Condensed Matter Physics, Epitaxy, symbols.namesake, Cross section (physics), Quality (physics), symbols, Optoelectronics, Nanorod, Raman spectroscopy, business, Single crystal, Wurtzite crystal structure
Abstract

High-quality GaN nanorods with triangular cross section were synthesized via a simple chloride-assisted vapor phase epitaxy method. High-resolution transmission electron microscopic observations show that the synthesized GaN nanorods are single crystal with wurtzite hexagonal structure. Raman and photoluminescence measurements were also carried out to study the optical properties of the as-prepared GaN nanorods, which suggests the potential applications in optoelectronic devices.

Published
2005

52. Antiphospholipid antibody-mediated interference with annexin-V anticoagulant activity

Author

J. H. Rand and X.-X. Wu

Subjects
medicine.medical_specialty, Lupus anticoagulant, biology, business.industry, Trophoblast, Hematology, medicine.disease, Thrombosis, Tissue factor, Endocrinology, medicine.anatomical_structure, Coagulation, Annexin, Antiphospholipid syndrome, Internal medicine, medicine, biology.protein, lipids (amino acids, peptides, and proteins), Antibody, business
Abstract

SummaryThe antiphospholipid (aPL) syndrome is a disorder in which vascular thrombosis and/or recurrent pregnancy losses occur together with serologic and coagulation evidence for antibodies directed against anionic phospholipid-protein complexes. Evidence has been developed for the idea that thrombosis in this syndrome may result from disruption of the binding of annexin-V to the phospholipids which line the placental and systemic vasculatures. We hypothesize that annexin-V, a protein known to have high affinity for anionic phospholipids, plays a thromboregulatory role at the vascular-blood interface by shielding anionic phospholipids from complexation with coagulation proteins in circulating blood. We propose that the thrombotic manifestations of the antiphospholipid syndrome are due to disruption of this annexin-V shield by antiphospholipid antibodies, thereby resulting in a net increase of thrombogenic phospholipids exposed to circulating blood. The accumulated data from tissue immunohistochemistry, trophoblast and endothelial cell culture studies, coagulation studies using noncellular phospholipids, and competition studies on artificial phospholipid bilayer are consistent with the hypothesis that the interference with the binding of annexin-V to anionic phospholipid surfaces plays an important role in the mechanism of thrombosis and in pregnancy loss in the antiphospholipid syndrome.

Published
2001

53. Experimental Study of Two-Phase Flow Oscillation in Natural Circulation

Author

X. X. Wu, S. Y. Jiang, and Y. J. Zhang

Subjects
Natural convection, Materials science, 010308 nuclear & particles physics, Flow (psychology), 0211 other engineering and technologies, Thermodynamics, 02 engineering and technology, Mechanics, Flashing, 01 natural sciences, Subcooling, Natural circulation, Nuclear Energy and Engineering, Boiling, 0103 physical sciences, Vapor quality, 021108 energy, Two-phase flow
Abstract

The experiment was performed on the test loop HRTL-5, which simulates the geometry and system design of the 5-MW nuclear heating reactor developed by the Institute of Nuclear Energy Technology, Tsinghua University. The flow behavior for a wide range of inlet subcoolings, in which the flow experience varies from single- to two-phase, is described in a natural circulation system at different pressures (p = 0.1, 0.24, and 1.5 MPa). Several kinds of flow instability are investigated, including geysering, flashing-related flow instability, and high-frequency flow oscillation at p = 0.1 and 0.24 MPa, as well as low steam quality density wave oscillation at p = 1.5 MPa. The mechanisms of geysering, which has new features, and flashing-related flow instability, which has never been studied well enough in this field, are particularly interpreted. The experimental results show the following: First, for a low-pressure natural circulation system, the two-phase flow is unstable in most inlet subcooling conditions, and the two-phase stable flow can be reached only with very low inlet subcoolings. Second, at high inlet subcoolings, the flow instability is dominated by subcooling boiling in the heated section, and at intermediate inlet subcoolings, it is dominated by void flashing in the adiabatic longmore » riser. Third, in the two-phase stable flow region, the conditions for boiling out of the core, namely, single-phase flow in the heated section and two-phase flow in the riser due to vapor flashing, can be realized. The experimental results are of significance for the design and accident analysis of vessel and swimming pool-type natural circulation nuclear heating reactors.« less

Published
2000

54. Flow excursion phenomenon in natural circulation at nuclear heating reactor conditions / Das Phänomen der Durchsatzschwankungen beim Naturumlauf in einem nuklearen Heizreaktor

Author

Y. J. Zhang, J. H. Bo, S. Y. Jiang, H. J. Jia, and X. X. Wu

Subjects
Nuclear and High Energy Physics, Radiation, Materials science, Isothermal flow, Excursion, Thermodynamics, Mechanics, Physics::Fluid Dynamics, Subcooling, Natural circulation, Nuclear Energy and Engineering, Flow (mathematics), Boiling, Mass flow rate, General Materials Science, Two-phase flow, Safety, Risk, Reliability and Quality
Abstract

The experiment was performed on the test loop (HRTL-5), which simulates the geometry and system design of a 5 MW nuclear heating reactor. In a wide range of inlet subcoolings different flow features, such as single phase stable flow, subcooled boiling stable flow, subcooled boiling static flow excursion, density wave oscillation and stable two phase flow in the natural circulation system have been described. The phenomenon and mechanism of static flow excursion, which has never been studied well in this field, is especially interpreted. The experimental results show that static flow excursion exists under certain inlet subcooling condition, in which only subcooled boiling occurs in the heated section. In the process of flow excursion the mass flow rate and the inlet temperature decreases, while the exit temperature increases smoothly. As the process of excursion continues for about 1 hour, bubbles enter in the flow channel resulting in short period dynamic flow oscillation which can only be seen in the process of this static flow excursion and has also never be studied well. These static and dynamic flow instabilities combine for about 2 hours. Then a point is reached, at which the static flow excursion stops, but the dynamic flow oscillation continues. The study of flow excursion and its concerned dynamic flow oscillation is of great significance for the development of nuclear heating reactor under natural circulation.

Published
1999

55. Experimental study on flashing concerned instability in a natural circulation system at nuclear heating reactor conditions / Experimentelle Studie zu Instabilitäten bei Siedeverzug in einem nuklearen Heizreaktor mit Naturumlauf

Author

S. Y. Jiang, X. X. Wu, J. H. Bo, P. Han, S. R. Wu, and Y. J. Zhang

Subjects
Nuclear and High Energy Physics, Radiation, Materials science, Flow (psychology), Thermodynamics, Mechanics, Nuclear reactor, Flashing, Instability, law.invention, Subcooling, Natural circulation, Nuclear Energy and Engineering, law, Boiling, General Materials Science, Two-phase flow, Safety, Risk, Reliability and Quality
Abstract

The experiment was performed on the test loop (HRTL-5), which simulates the geometry and system design of the 5 MW nuclear heating reactor. The flow behavior for a wide range of inlet subcoolings, in which the flow experience from single to two phase, is described in a natural circulation system at low pressure (p = 0.1, 0.24 MPa). Several kinds of flow instability are investigated, including subcooled boiling instability, subcooled boiling induced flashing instability, pure flashing instability as well as flashing coupled density wave instability and high frequency flow oscillation. The mechanism of flashing and flashing with regard to flow instability, which has never been studied well in this field, is particularly interpreted. The experimental results show that, firstly, for a low system pressure natural circulation the two phase flow is unstable in most inlet subcooling conditions, the two phase stable flow can only be achieved with very low inlet subcoolings; secondly, at high inlet subcoolings the flow instability is dominated by subcooled boiling in the heated section, and at intermediate inlet subcoolings it is dominated by void flashing in the adiabatic long riser; thirdly, in two phase stable flow region the condition for boiling out of the core, namely, single phase flow in the heated section, two phase flow in the riser due to vapor flashing, can be realized. The experimental results are very important for the design and accident analysis of the vessel and swimming pool type natural circulation nuclear heating reactor.

Published
1997

56. Autologous bone marrow mixed with HLA-haploidentical allogeneic marrow transplantation for treatment of patients with malignant blood diseases

Author

S. F. Xu, Yunlong Liu, C. B. Wang, Y. M. Wei, J. Z. Lu, X. X. Wu, Y. L. Wang, J. T. Zhong, H. Bai, W. M. Da, J. M. Chen, Qiang Zhang, and M. J. Ji

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Human leukocyte antigen, Transplantation, Autologous, Mice, HLA Antigens, Acute lymphocytic leukemia, Animals, Humans, Transplantation, Homologous, Medicine, Bone Marrow Transplantation, Transplantation, business.industry, Marrow transplantation, Histocompatibility Testing, Hematology, medicine.disease, Autologous bone, Histocompatibility, Lymphoma, Treatment Outcome, Hematologic Neoplasms, Immunology, Female, business
Abstract

We have previously demonstrated that syngeneic marrow mixed with H-2 haploidentical marrow transplantation could provide not only protection against graft-versus-host disease (GVHD) but also anti-leukemic (GVL) effects in mice. In the present studies, we report clinical observations using autologous marrow mixed with HLA-haploidentical allogeneic marrow transplantation for treatment of patients with malignant blood diseases. Sixteen cases, including 12 with acute leukemia and four with advanced malignant lymphoma, were treated by autologous marrow, which was purged in vitro by hyperthemia (42.5 degrees C for 70 min) following incubation for 5 days with interleukin 2 (IL-2) in liquid culture and mixed with HLA haploidentical marrow cells from their sibling or parent. Acute GVHD was not observed in any patient after transplantation. Hematological rescue in the clinical setting was demonstrated in all cases but one who died early from hepatic veno-occlusive disease (VOD). Five cases who were transplanted at the time of CR2 or CR3 and in advanced phase of lymphoma, relapsed 4 to 7 months after transplantation. The relapse rate was 31.3%. None of eight patients who received allogeneic BMT within 2 h after ABMT relapsed with median follow-up of 12 months and two of them died from procedure-related complications. Seven cases are still alive and disease-free with a median follow-up of 12 months. Mixed chimerism was found in 3/6 cases, who had different sex donors, by analysis of sex chromosomes. These results show that mixed transplantation is a safe, effective and new approach to treating patients with malignant tumors. In order to detect the effects of GVL, studies are now in progress in our clinic.

Published
1997

58. On the J-integral in periodically layered composites

Author

C.T. Sun and X. X. Wu

Subjects
J integral, Materials science, Mechanics of Materials, Homogeneous, Modeling and Simulation, Numerical analysis, Stress–strain curve, Computational Mechanics, Fracture mechanics, Composite material, Homogenization (chemistry)
Abstract

When a heterogeneous elastic material is represented by an effective homogeneous elastic solid, average stress and strain fields are used. The meaning of the J-integral in the effective homogeneous solid is investigated. A periodically layered medium is considered. The relation between the J-integrals in the original layered medium and the effective medium is derived.

Published
1996

59. Efficient modeling of postbuckling delamination growth in composite laminates using plate elements

Author

J. C. Klug, X. X. Wu, and C.T. Sun

Subjects
Strain energy release rate, Fiber pull-out, Crack closure, Materials science, Fracture toughness, business.industry, Delamination, Aerospace Engineering, Fracture mechanics, Structural engineering, Composite laminates, business, Finite element method
Abstract

Under compression, delaminated composite plates may undergo postbuckling that can lead to delamination growth. The use of three-dimensional finite elements for the calculation of the strain energy release rate at the delamination front is computationally expensive. The Mindlin plate finite element is used to perform the postbuckling analysis and to compute the strain energy release rate at the delamination front with the aid of the crack closure method. Comparison of the present strain energy release rate calculation with the existing three-dimensional result indicates that the present method is efficient and accurate. For stationary delamination cracks, the effects of stacking sequence and shape of delamination are examined. A procedure of determining delamination front location for a propagating delamination is presented. Delamination growth initiated from embedded and edge delaminations is investigated using this procedure.

Published
1996

60. Semi-quantitative analysis of telomerase activity of exfoliated cells in urine of patients with urothelial cancers: Causative factors affecting sensitivity and specificity

Author

T, Akao, Y, Kakehi, X X, Wu, H, Kinoshita, T, Takahashi, O, Ogawa, T, Kato, and O, Yoshida

Abstract

We previously reported that detection of telomerase activity in urinary exfoliated cells obtained from urothelial cancer patients by telomeric repeat amplification protocol (TRAP) assay is a more sensitive method of diagnosis than conventional urine cytologic examination, particularly in patients with grade 1 tumors. To establish this method as a noninvasive screening test for the diagnosis of urothelial cancers, we performed the semi-quantitative analysis of telomerase activity using Telomerase PCR ELISA™. Spontaneous voided urine samples were obtained from 65 urothelial and 58 non-urothelial cancer patients. When the mean + 2 standard deviation of telomerase activity in urine sediments of non-urothelial cancer patients was arbitrarily determined as a cut-off, the sensitivity of TRAP enzyme-linked immunosorbent assay (ELISA) and the conventional cytology were 57% and 35%, respectively. Detection rate was significantly higher in semi-quantitative TRAP assay than in conventional cytologic examination in grade 1 cancer patients (52% vs. 5%, p = 0.00195). False positives were detected in 5% of non-urothelial cancer patients without pyuria and in 11% of non-urothelial cancer patients with pyuria (p = 0.395). Telomerase activity was enhanced in some cases after phenol extraction or extracting epithelial cells by using Dynabeads of macroscopic hematuria and pyuria, indicating that hematuria and pyuria might contribute to false negatives. In conclusion, the TRAP-ELISA method is superior to the standard TRAP assay in quantitativeness and simplicity of the experimental procedure. Detection of telomerase activity in urine sediments is particularly useful for the diagnosis of low-grade tumors. However, telomerase activity in patients with high grade tumors often might be underestimated due to the excessive amount of exfoliated epithelia with necrotic tissues, hematuria, and pyuria.

Published
2011

61. Association of SCD1 and DGAT1 SNPs with the intramuscular fat traits in Chinese Simmental cattle and their distribution in eight Chinese cattle breeds

Author

X. X. Wu, Lingling Chang, H. J. Gao, Yongjiang Mao, J. Y. Li, Zhangping Yang, X. K. Shi, and Dejun Ji

Subjects
Genetic Markers, Veterinary medicine, China, Meat, Genotype, Marbled meat, Adipose Tissue, White, Single-nucleotide polymorphism, Beef cattle, Biology, Breeding, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, food, Gene Frequency, Species Specificity, Simmental cattle, Genetics, Animals, Diacylglycerol O-Acyltransferase, Muscle, Skeletal, Molecular Biology, Genetic Association Studies, Polymorphism, Single-Stranded Conformational, DNA Primers, Haplotype, food.cheese_milk_source, General Medicine, Breed, Genetic marker, Body Composition, Linear Models, lipids (amino acids, peptides, and proteins), Cattle, Intramuscular fat, Stearoyl-CoA Desaturase
Abstract

Intramuscular fat (IMF) is a key parameter for evaluation of nutritional quality of beef, with its endogenous synthesis regulated by stearoyl CoA desaturase (SCD1) and diacylglycerol-acyl transferase 1 (DGAT1) genes in cattle. The object of this research was to evaluate the effect of SCD1 and DGAT1 polymorphisms on IMF trait in beef cattle and to estimate the frequency distribution of SNPs in the two genes in Chinese cattle populations. The SCD1 and DGAT1 polymorphisms were detected by PCR-single strand conformation polymorphism (PCR-SSCP) method in Chinese Simmental cattle and their associations with IMF traits were analyzed using the general linear model (GLM). The frequency distribution of SNPs in SCD1 and DGAT1 genes were detected by PCR-SSCP method and analyzed in seven other cattle populations. The results showed significant associations of SNPs SCD1-878, SCD1-762, and DGAT1 10433 and 10434 with IMF (%) and shearing force values (SFV; kg) in Chinese Simmental cattle. A haplotype combining SCD1-878C, SCD1-762T, and DGAT1 10433 and 10434-GC had the highest IMF, marbling score and shearing force. The polymorphic investigation indicated that the frequency of SCD1-878C or SCD1-762T was significantly higher in Chinese southern cattle (Leiqiong, Yunnan High pump, BMY or Minnan Cattle) than in Chinese northern cattle (Chinese Simmental, Luxi Cattle, Bohai Black or Chinese Holstein), while the frequency of DGAT1 10433 and 10434-GC in Chinese indigenous breed (Leiqiong, Yunnan High pump, BMY, Luxi Cattle, Bohai Black, or Minnan Cattle) was significantly lower than breeds with imported blood (Chinese Simmental or Chinese Holstein). These findings demonstrated that both the SCD1 and DGAT1 SNPs were prospect genetic markers for IMF traits, and the SCD1 SNPs could be used as a genetic marker for southern or northern blood in Chinese cattle.

Published
2011

62. Vibration analysis of laminated composite thin-walled beams using finite elements

Author

C.T. Sun and X. X. Wu

Subjects
Materials science, Cantilever, business.industry, Composite number, Aerospace Engineering, Structural engineering, Aspect ratio (image), Finite element method, Poisson's ratio, Physics::Fluid Dynamics, Vibration, symbols.namesake, Node (physics), symbols, Material properties, business
Abstract

A two-noded, 10 degree of freedom per node, laminated composite thin-walled beam finite element was developed. The element presented here is suitable for either open-section or closed-section beams of any shape. Natural frequencies of several thin-walled composite structures were calculated.

Published
1991

63. A low molecular weight polysaccharide isolated from Agaricus blazei suppresses tumor growth and angiogenesis in vivo

Author

Y C, Niu, J C, Liu, X M, Zhao, and X X, Wu

Subjects
Vascular Endothelial Growth Factor A, Neovascularization, Pathologic, Reverse Transcriptase Polymerase Chain Reaction, Agaricus, Angiogenesis Inhibitors, Enzyme-Linked Immunosorbent Assay, Chick Embryo, Neoplasms, Experimental, Immunohistochemistry, Xenograft Model Antitumor Assays, Fungal Proteins, Mice, Polysaccharides, Animals
Abstract

Previous studies indicated that the low molecular weight polysaccharide extracts from Agaricus blazei are potential antitumor agents or adjuvant in tumor treatment. In this study, we investigated the antitumor activity of LMPAB, a low molecular weight polysaccharide isolated from Agaricus blazei, and the molecular mechanisms of its antitumor activity. The antitumor effect of LMPAB was examined using mouse sarcoma 180 (S180) xenograft models. Antiangiogenic effect of LMPAB was determined by chicken embryo chorioallantoic membrane (CAM) angiogenesis and Matrigel-induced neovascularization in vivo models. The mRNA and protein levels of vascular endothelial growth factor (VEGF) were assessed using real-time reverse transcription-polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assays. Tumor inhibitory rates in the S180 xenograft models were 9.7, 23.9, and 33.0%, respectively, after administration of LMPAB at dose of 50, 100, and 200 mg/kg/day for 2 weeks. LMPAB also inhibited angiogenesis in the CAM model and Matrigel-induced neovascularization in C57BL/6 mice. The mRNA and protein levels of VEGF in tumor tissues were significantly down-regulated in the BALB/c mice received LMPAB treatment. Furthermore, significant down-regulation of serum VEGF levels was also observed in the mice. Our data suggest that LMPAB might be a promising agent for tumor therapy, and the antitumor and antiangiogenic effects of LMPAB may be related with down-regulation of VEGF.

Published
2008

64. Sequence characterization, polymorphism, and chromosomal localizations of the porcine CapZ genes

Author

E. Yang, Kui Li, X. X. Wu, S. L. Yang, Huanling Wang, and Z. L. Tang

Subjects
Swine, Population, Single-nucleotide polymorphism, Biology, Biochemistry, Polymorphism, Single Nucleotide, Chromosomes, Gene Frequency, Species Specificity, Chromosome 18, Genotype, Genetics, Animals, Cloning, Molecular, education, Muscle, Skeletal, Molecular Biology, Ecology, Evolution, Behavior and Systematics, CapZ Actin Capping Protein, education.field_of_study, Intron, CapZ, Chromosome Mapping, General Medicine, Molecular biology, Actins, Chromosome 4, Gene Expression Regulation, Organ Specificity, Swine, Miniature, Restriction fragment length polymorphism
Abstract

CapZ is a widely distributed and highly conserved actin-binding protein that caps the barbed end of actin filaments and nucleates actin polymerization in a Ca(2+)-independent manner. In myofibrils, it is localized in the Z-lines. In this study, we cloned and characterized Capz subunit genes from the pig muscle. The nucleotide sequences and the predicted protein sequences share high sequence identity with other mammalian orthologs. The reverse transcriptase polymerase chain reaction (RT-PCR) revealed that porcine Capzbeta, Capzalpha1, and Capzalpha2 genes are expressed in all 11 tissues studied (liver, spleen, small intestine, large intestine, lymph node, kidney, heart, skeletal muscle, brain, fat, and lung) but in variable amounts. Radiation hybrid mapping data indicated that Capzbeta, Capzalpha1, and Capzalpha2 map to q2.1-2.6 of pig chromosome 6 (SSC6), q1.6-q2.2 of pig chromosome 4 (SSC4), and q1.3-2.3 of pig chromosome 18 (SSC18), respectively. An A/C single nucleotide polymorphism in Capzbeta intron 4 was identified with a HhaI PCR restriction fragment length polymorphism, which showed great allele frequency differences between Guizhou Xiang, Guangxi Bama, Wuzhishan, Tongcheng, Landrace, and Yorkshire pigs. The association analysis suggested that the Capzbeta genotype was associated with leaf fat (P0.05) in our experimental population.

Published
2007

65. Monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) induces apoptosis in primary renal cell carcinoma cells in vitro and inhibits tumor growth in vivo

Author

X. X. Wu, Vivian R. Albert, Y. Zeng, Michele Fiscella, Yoshiyuki Kakehi, Osamu Shimada, and Robin Humphreys

Subjects
Male, Cancer Research, Pathology, medicine.medical_specialty, Programmed cell death, Cell Survival, Cell, Cell Culture Techniques, Mice, Nude, Apoptosis, Mice, SCID, Biology, urologic and male genital diseases, Receptors, Tumor Necrosis Factor, TNF-Related Apoptosis-Inducing Ligand, Mice, Cell Line, Tumor, medicine, Animals, Humans, Enzyme Inhibitors, Receptor, Carcinoma, Renal Cell, Cell Membrane, Antibodies, Monoclonal, Cell cycle, Caspase Inhibitors, Xenograft Model Antitumor Assays, Kidney Neoplasms, Receptors, TNF-Related Apoptosis-Inducing Ligand, medicine.anatomical_structure, Oncology, Cell culture, Caspases, Monoclonal, Cancer research, Tumor necrosis factor alpha
Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in a variety of tumor cells through two of its receptors: TRAIL-R1 and TRAIL-R2. We investigate the susceptibility of human renal cell carcinoma (RCC) cells to TRM-1 and HGS-ETR2, 2 human monoclonal agonistic antibodies specific for TRAIL-R1 and TRAIL-R2, respectively. HGS-ETR2 effectively induced apoptotic cell death in 10 of 11 cell cultures, including 2 human RCC cell lines and 9 human primary RCC cell cultures, with a more pronounced effect after preincubation with anti-human IgG Fc. In contrast, TRM-1 was effective in only 1 primary RCC cell culture. The increased effectiveness of HGS-ETR2 for inducing cell death might have been affected by differences in the cell-surface expression of the 2 TRAIL receptors, namely that TRAIL-R2 but not TRAIL-R1 was frequently expressed in most of the RCC cells tested. The activities of caspase-9, -8, -6, and -3 were increased with HGS-ETR2-induced apoptosis, and cell death could be blocked by specific caspase inhibitors for caspase-9, -8, and -3, and the general caspase inhibitor. In vivo administration of HGS-ETR2 with or without cross-linker significantly suppressed tumor growth of subcutaneously inoculated human RCC xenografts in immunodeficient mice. These results suggest the potential utility of TRAIL-R2 antibody as a novel therapeutic agent in RCC.

Published
2006

66. Enhancement of arsenic trioxide-induced apoptosis in renal cell carcinoma cells by L-buthionine sulfoximine

Author

X X, Wu, O, Ogawa, and Y, Kakehi

Subjects
Apoptosis, Drug Synergism, Oxides, Vinblastine, Glutathione, Arsenicals, Kidney Neoplasms, Arsenic Trioxide, Doxorubicin, Caspases, Antineoplastic Combined Chemotherapy Protocols, Tumor Cells, Cultured, Humans, Fluorouracil, Buthionine Sulfoximine, Carcinoma, Renal Cell, Oxidation-Reduction, Cell Division, Glutathione Transferase
Abstract

Arsenic trioxide (As2O3) induces clinical remission in acute promyelocytic leukemic patients and apoptosis in various tumor cells in vitro. To develop As2O3-based combination chemotherapy for renal cell carcinoma (RCC), we investigated the cytotoxic effects of As2O3 in combination with chemotherapeutic agents or L-buthionine sulfoximine (BSO), a glutathione (GSH) synthesis inhibitor. Cytotoxicity and synergy were assessed by the MTT assay and isobolographic analysis, respectively. Apoptosis was monitored by Hoechst 33342 staining, flow cytometrical analysis, and DNA fragmentation assay. Treatment of ACHN cells with As2O3 in combination with adriamycin, vinblastine, or 5-fluorouracil induced an antagonistic effect. However, combination treatment with As2O3 and BSO resulted in a synergistic cytotoxic effect. Synergy was also obtained in Caki-1, Caki-2, NC65 cells and freshly derived RCC cells from 6 patients. Simultaneous treatment of ACHN cells with As2O3 and BSO caused significantly more cytotoxicity than the As2O3 first BSO second or the reverse treatment. We further explored the mechanisms underlying this synergistic effect and found that the synergistic cytotoxicity of As2O3 and BSO was realized by inducing apoptosis. This combination markedly decreased intracellular GSH content and GSH-S-transferase (GST) activity. However, neither the intracellular GSH nor GST was decreased by As2O3 with adriamycin, vinblastine, or 5-fluorouracil. Furthermore, the GSH-increasing agents N-acetylcysteine and lipoic acid significantly inhibited the combined cytotoxicity of As2O3 and BSO. These findings indicate that BSO sensitizes RCC cells to As2O3-induced apoptosis through the down-regulation of the intracellular GSH redox system, suggesting the potential application of a combination of As2O3 and BSO for the treatment of RCC.

Published
2004

69. [The effect of lycium barbarum polysaccharide on vascular tension in two-kidney, one clip model of hypertension]

Author

Y X, Jia, J W, Dong, X X, Wu, T M, Ma, and A Y, Shi

Subjects
Male, In Vitro Techniques, Nitric Oxide, Rats, Phenylephrine, Random Allocation, Hypertension, Renovascular, Polysaccharides, Vasoconstriction, Animals, Rats, Wistar, Aorta, Solanaceae, Drugs, Chinese Herbal
Abstract

In the present study, the effects of lycium barbarum polysaccharide (LBP) on endothelial function in the two-kidney, one clip model of hypertension were observed. The results showed that the increase of blood pressure in hypertension rats (HR) could be prevented significantly by treatment with 10% LBP. In isolated aortic rings of LBP-treated rats, the contraction of phenylephrine (PE) was reduced as compared with HR rats. Removal of the endothelium abolished the difference of PE-induced vasoconstriction among groups. In vitro incubation of aortic rings from LBP-treated rats with methyl blue (MB) or N-nitro-L-arginine methyl ester (L-NAME) increased the magnitude of PE-induced contraction. Meanwhile the response to acetylcholine (ACh) was significantly increased in LBP-treated rats, but the response to nitroprusside had no significant difference among groups. Pretreatment with L-arginine partially restored ACh-induced relaxation in RH rats, but no effect in LBP-treated rats. These results suggested that the role of LBP in decreasing vasoconstriction to PE may be mediated by increase of the effects or/and production of endothelium-derived relaxation factor (EDRF). LBP increased formation of EDRF may be related to increase the substrate of EDRF.

Published
2001

70. Detection of circulating cancer cells by reverse transcription-polymerase chain reaction for uroplakin II in peripheral blood of patients with urothelial cancer

Author

J J, Lu, Y, Kakehi, T, Takahashi, X X, Wu, T, Yuasa, T, Yoshiki, Y, Okada, T, Terachi, and O, Ogawa

Subjects
Adult, Aged, 80 and over, Male, Carcinoma, Transitional Cell, Urologic Neoplasms, Reverse Transcriptase Polymerase Chain Reaction, Membrane Proteins, Middle Aged, Neoplastic Cells, Circulating, Sensitivity and Specificity, Kidney Neoplasms, Urinary Bladder Neoplasms, Lymphatic Metastasis, Uroplakin II, Biomarkers, Tumor, Carcinoma, Squamous Cell, Humans, Female, RNA, Messenger, Neoplasm Metastasis, Carcinoma, Renal Cell, Aged
Abstract

Few attempts have been made at the molecular detection of urothelial cancer cells in the blood or lymph nodes mainly because of an absence of good candidate molecular or genetic changes specific to urothelial cancer or urothelium. In 1990, however, genes that encode urothelium-specific transmembrane proteins, uroplakins (UPs), were cloned. We have established a method of detecting circulating cancer cells in peripheral blood of patients with transitional cell carcinoma by nested reverse transcription-PCR assay for UP II. UP II mRNA-positive cells were detected in 3 (10.3%) of 29 patients with superficial cancers (pTa-1N0M0), 4 (28.6%) of 14 patients with muscularly invasive cancers (pT2-4N0M0), 2 (40.0%) of 5 loco-regional node-positive patients (pN1-2M0), and 6 (75.0%) of 8 patients with distant metastases. Positive rates, therefore, increased with tumor extension (P = 0.0033, Kruskal-Wallis test). Furthermore, sequential blood sampling was performed in three patients with metastases during and after systemic chemotherapy, and UP-II-positive cells were found to have disappeared in two patients who responded well to the systemic chemotherapy. These results suggest that our nested reverse transcription-PCR assay for UP II is highly specific and might be used as a tumor marker for molecular staging of urothelial cancers, although the sensitivity is not so optimal.

Published
2000

71. Enhancement of Fas-mediated apoptosis in renal cell carcinoma cells by adriamycin

Author

X X, Wu, Y, Mizutani, Y, Kakehi, O, Yoshida, and O, Ogawa

Subjects
Antimetabolites, Antineoplastic, Time Factors, Antineoplastic Agents, Vinblastine, Interferon-gamma, Lymphocytes, Tumor-Infiltrating, Proto-Oncogene Proteins, Tumor Cells, Cultured, Humans, Drug Interactions, fas Receptor, Carcinoma, Renal Cell, Epirubicin, Fluorescent Dyes, bcl-2-Associated X Protein, Antibiotics, Antineoplastic, Dose-Response Relationship, Drug, Caspase 3, Interferon-alpha, Antineoplastic Agents, Phytogenic, Immunohistochemistry, Acridine Orange, Kidney Neoplasms, Proto-Oncogene Proteins c-bcl-2, Doxorubicin, Caspases, Fluorouracil, Tumor Suppressor Protein p53
Abstract

Anti-Fas monoclonal antibody (mAb) kills Fas-expressing cells by apoptosis. Several anticancer agents also mediate apoptosis and may share common intracellular pathways leading to apoptosis with Fas. Thus, we reasoned that combination treatment of drug-resistant cells with anti-Fas mAb and drugs might overcome their resistance. We investigated whether anticancer agents enhance Fas-mediated apoptosis and cytotoxicity against renal cell carcinoma (RCC) cells. Treatment of ACHN RCC cells with anti-Fas mAb in combination with 5-fluorouracil, vinblastine, IFN-alpha, or IFN-gamma did not overcome resistance to these agents. However, combination treatment with anti-Fas mAb and Adriamycin (ADR) resulted in a synergistic cytotoxic effect. Furthermore, synergy was also obtained even when the exposure time was shortened from 24 h to 8 or 2 h. Synergy was also achieved in four other RCC cell lines and five freshly derived human RCC cells. Treatment with anti-Fas mAb in combination with epirubicin or pirarubicin also resulted in a synergistic cytotoxic effect on ACHN cells. Similar results were achieved with a combination of humanized anti-Fas mAb and ADR. Incubation of ACHN cells with ADR augmented the expression of Fas and p53, but not Bcl-2, Bax, or caspase-3. However, the activity of caspase-3 itself was apparently enhanced after treatment with ADR alone or combined treatment with anti-Fas mAb. The synergy obtained in cytotoxicity with anti-Fas mAb and ADR was also achieved in apoptosis. Exposure of ACHN cells and freshly derived RCC cells to ADR enhanced their susceptibility to lysis by peripheral blood lymphocytes and tumor-infiltrating lymphocytes. This study demonstrates that combination treatment of RCC cells with anti-Fas mAb and ADR might overcome their resistance. The sensitization required a low concentration of ADR and a short exposure time, thus supporting the potential in vivo application of a combination of ADR and anti-Fas mAb or immunotherapy in the treatment of ADR- and/or immunotherapy-resistant RCC.

Published
2000

74. Chemoimmunosensitization of the T24 human bladder cancer line to Fas-mediated cytotoxicity and apoptosis by cisplatin and 5-fluorouracil

Author

T Shirasaka, X X Wu, Osamu Yoshida, B Bonavida, and Y Mizutani

Subjects
inorganic chemicals, Cytotoxicity, Immunologic, Cancer Research, medicine.medical_treatment, Antineoplastic Agents, Apoptosis, Tumor Cells, Cultured, Medicine, Cytotoxic T cell, Humans, fas Receptor, Cytotoxicity, neoplasms, Cisplatin, Bladder cancer, business.industry, Cancer, Antibodies, Monoclonal, Drug Synergism, General Medicine, Immunotherapy, medicine.disease, female genital diseases and pregnancy complications, Cell killing, Oncology, Urinary Bladder Neoplasms, Drug Resistance, Neoplasm, Immunology, Cancer research, Drug Therapy, Combination, Fluorouracil, business, medicine.drug
Abstract

Previous studies have demonstrated that cisplatin (CDDP) sensitizes bladder cancer cells to Fas-mediated cytotoxicity and that CDDP also enhances the cytotoxic effect of 5-fluorouracil (5-FU). These agents mediate apoptosis and may share common intracellular pathways leading to cell killing. We reasoned that combination treatment with CDDP, 5-FU and anti-Fas monoclonal antibody (mAb) might overcome the drug-resistance. We investigated whether CDDP, 5-FU and anti-Fas mAb synergize in cytotoxicity and apoptosis against the T24 bladder cancer line. Cytotoxicity was monitored by a one day microculture tetrazolium dye assay. Treatment of T24 cells with anti-Fas mAb in combination with CDDP or 5-FU resulted in a synergistic cytotoxic effect. In addition, combination treatment of T24 cells with CDDP, 5-FU and anti-Fas mAb further enhanced the synergistic cytotoxicity achieved by two agents. The synergy achieved in cytotoxicity with CDDP, 5-FU and anti-Fas mAb was also achieved in apoptosis. The current study demonstrates that combination treatment of bladder cancer cells with CDDP, 5-FU and anti-Fas mAb overcomes their resistance. In addition, the sensitization required low concentrations of CDDP and 5-FU, and thus supporting the potential in vivo application of combination of CDDP, 5-FU and immunotherapy in the treatment of drug-resistant bladder cancer.

Published
1999

75. [Expression of major histocompatibility complex antigens and adhesion molecules on renal cell carcinoma cells, and effect of interferon-alpha and/or cimetidine on the expression]

Author

X X, Wu, Y, Mizutani, Y, Kakehi, E, Nakamura, K, Mitsumori, T, Takahashi, T, Terachi, Y, Okada, and O, Yoshida

Subjects
Cytotoxicity, Immunologic, Adjuvants, Immunologic, Histocompatibility Antigens Class I, Tumor Cells, Cultured, Humans, Interferon-alpha, Antineoplastic Agents, Cimetidine, Intercellular Adhesion Molecule-1, Carcinoma, Renal Cell, Kidney Neoplasms, T-Lymphocytes, Cytotoxic
Abstract

Recently the combined therapy with interferon-alpha (IFN-alpha) and cimetidine has been reported to be effective against advanced renal cell carcinoma (RCC). IFN-alpha and cimetidine have an antitumor effect partly due to enhancement of cytotoxic activity of lymphocytes against cancer cells. We examined the expression of major histocompatibility complex (MHC) antigens and adhesion molecules on 4 fresh RCC cells and 5 RCC cultured cell lines, which have an important role in recognition and killing of cytotoxic lymphocytes against cancer cells. The effect of treatment with IFN-alpha and/or cimetidine on the expression of MHC antigens and adhesion molecules on RCC cells was also investigated. MHC class I and leukocyte function-associated antigen-3 (LFA-3) were expressed on all RCC cells, but not MHC class II. Intercellular adhesion molecule-1 (ICAM-1) and B7 were expressed on 6 and 5 of 8 RCC cells, respectively. IFN-alpha significantly augmented the expression of MHC class I in 6 of 9 RCC cells, ICAM-1 in 1 and LFA-3 in 2 of 8 RCC cells. However, IFN-alpha did not affect the expression of MHC class II and B7. On the other hand, cimetidine enhanced the expression of LFA-3 in 2 of 8 RCC cells, but not MHC antigens, ICAM-1 or B7. The combination of IFN-alpha and cimetidine did not show a synergistic enhancing effect on the expression of MHC antigens, ICAM-1, LFA-3 or B7. These results suggest that IFN-alpha augments the sensitivity of RCC cells to lysis by cytotoxic lymphocytes partly due to the enhancement of expression of MHC class I, ICAM-1 and LFA-3 on RCC cells, and that cimetidine also augments the susceptibility of RCC cells to lymphocytes by the enhanced expression of LFA-3 on RCC cells.

Published
1998

76. Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: a 'lupus procoagulant' phenomenon

Author

J H, Rand, X X, Wu, H A, Andree, J B, Ross, E, Rusinova, M G, Gascon-Lema, C, Calandri, and P C, Harpel

Subjects
Blood Platelets, Lipid Bilayers, Phosphatidylserines, Thromboplastin, Immunoglobulin G, Lupus Coagulation Inhibitor, Antibodies, Antiphospholipid, Prothrombin Time, Humans, Indicators and Reagents, Partial Thromboplastin Time, Annexin A5, Blood Coagulation, Fluorescein-5-isothiocyanate, Phospholipids, Fluorescent Dyes
Abstract

The antiphospholipid syndrome is a thrombophilic condition marked by antibodies that recognize anionic phospholipid-protein cofactor complexes. We recently reported that exposure to IgG fractions from antiphospholipid patients reduces the level of annexin-V, a phospholipid-binding anticoagulant protein, on cultured trophoblasts and endothelial cells and accelerates coagulation of plasma exposed to these cells. Therefore, we asked whether antiphospholipid antibodies might directly reduce annexin-V binding to noncellular phospholipid substrates. Using ellipsometry, we found that antiphospholipid IgGs reduce the quantity of annexin-V bound to phospholipid bilayers; this reduction is dependent on the presence of beta2-glycoprotein I. Also, exposure to plasmas containing antiphospholipid antibodies reduces annexin-V binding to phosphatidyl serine-coated microtiter plates, frozen thawed washed platelets, activated partial thromboplastin time (aPTT) reagent and prothrombin time reagent and reduces the anticoagulant effect of the protein. These studies show that antiphospholipid antibodies interfere with the binding of annexin-V to anionic phospholipid and with its anticoagulant activity. This acceleration of coagulation, due to reduced binding of annexin V, stands in marked contrast to the "lupus anticoagulant effect" previously described in these patients. These results are the first direct demonstration of the displacement of annexin-V and the consequent acceleration of coagulation on noncellular phospholipid surfaces by antiphospholipid antibodies.

Published
1998

77. The significance of subendothelial von Willebrand factor

Author

J H, Rand, R W, Glanville, X X, Wu, J M, Ross, M, Zangari, R E, Gordon, E, Schwartz, and B J, Potter

Subjects
Blood Platelets, Binding Sites, von Willebrand Factor, Animals, Humans, Endothelium, Vascular, Extracellular Matrix
Abstract

von Willebrand factor (vWf) serves to bridge between receptors on the platelet cytoplasmic membrane and the extracellular matrix. In addition to circulating in plasma, vWf is deposited into the extracellular matrix of the subendothelium where it is associated with type VI collagen microfibrils, but not with the elastin-associated microfibrils which are present in the deepest portion of the subendothelium at the zone of the internal elastic lamina. The reaction of platelets to type VI collagen in flow systems is qualitatively different from the shear rate dependent adhesion and aggregation response which is observed with fibrillar type I collagen, exhibiting a response only at low shear rates. The adhesion response to type VI collagen is dependent upon vWf, GP Ib and the GP IIb-IIIa complex. Platelets exposed to purified fibrillin-containing elastin-associated microfibrils adhere and aggregate at low shear rates; this response appears to involve GP IIb-IIIa but not GP Ib. The data are consistent with the hypothesis that type VI collagen is a physiologically relevant binding site for vWf in subendothelium.

Published
1997

79. [Dig-DNA probe for etiologic diagnosis in tuberculosis patients]

Author

S N, Wei, P, Yang, and X X, Wu

Subjects
DNA, Bacterial, Base Sequence, Molecular Sequence Data, Sputum, Humans, Mycobacterium tuberculosis, DNA Probes, Sensitivity and Specificity, Tuberculosis, Pulmonary
Abstract

We have detected the sputa DNA with nonradioactive probe which is labelled to the specific sequence DNA, 31bp-188bp, by dig-11-dUTP. It showed that both the Sensitivity and specificity are satisfactory. The positive rate of the 80 specimens are 56.25%, and the 30 positive specimens of sputum culture are all positive when detected by the Dig-DNA probe.

Published
1993

80. [Screening of anti-simian immunodeficiency virus (SIV) drugs from Chinese medicinal herbs]

Author

C F, Guan, Y Z, Wang, and X X, Wu

Subjects
Drug Evaluation, Preclinical, Simian Immunodeficiency Virus, Antiviral Agents, Drugs, Chinese Herbal
Abstract

The inhibitory activities of more than 40 species of Chinese medicinal herbs or their single chemical components against simian immunodeficiency virus (SIV) have been studied. The study revealed that four species of the medicinal herbs and a single chemical component had more than 50% inhibition of SIV antigen expression and five other herbs' inhibitory rate of SIV antigen expression was between 30-50%. The results showed that Chinese medicinal herbs could inhibit the SIV activity.

Published
1993

84. Evidence of line nodes in superconducting gap function in K2Cr3As3 from specific-heat measurements.

Author

Y. T. Shao, X. X. Wu, L. Wang, Y. G. Shi, J. P. Hu, and J. L. Luo

Abstract

We present low-temperature specific-heat measurements of the quasi–one-dimensional superconductors . Our result shows a sharp specific-heat jump around with , which is much larger than the BCS prediction for a weak-coupling superconductor. It indicates that this superconductor is in the strong-coupling regime. After subtracting the lattice contribution and the Schottky anomaly from the total specific-heat data, the low-temperature electronic specific heat is proportional to T2 at different fields and also proportional to at different temperatures below 2.5 K. These results indicate that line nodes are present in the superconducting gap function of . [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

86. Amelioration of salt-induced oxidative stress in eggplant by application of 24-epibrassinolide

Author

H. -D. Ding, X. -H. Zhu, Z. -W. Zhu, S. -J. Yang, D. -S. Zha, and X. -X. Wu

Subjects
ascorbate peroxidase, ascorbic acid, catalase, brassinosteroids, elecrolyte leakage, glutathione, guaiacol peroxidase, ion balance, reactive oxygen species, solanum melongena, superoxide dismutase, Biology (General), QH301-705.5, Plant ecology, QK900-989
Abstract

The effects of exogenous 24-epibrassinolide (EBR) on the growth, oxidative damage, antioxidant system and ion contents in eggplant (Solanum melongena L.) seedlings under salt stress were investigated. Eggplant seedlings were exposed to 90 mM NaCl with 0, 0.025, 0.05, 0.10 and 0.20 mg dm-3 EBR for 10 d. EBR, especially at concentration 0.05 mg dm-3, alleviated growth suppression caused by NaCl stress, decreased electrolyte leakage, superoxide production and content of malondialdehyde and H2O2 in NaCl-treated plants. EBR also increased activities of superoxide dismutase, guaiacol peroxidase, catalase and ascorbate peroxidase and the contents of ascorbic acid and reduced glutathione. Furthermore, we also found that Na+, Cl- contents were decreased, K+, Ca2+ contents and K+/Na+, Ca2+/Na+ ratios were increased in the presence of EBR under salt stress.

Published
2012
Full Text
View/download PDF

87. Observation of superconductivity and anomalous electrical resistivity in single-crystal Ir3Te8.

Author

L. Li, T. F. Qi, L. S. Lin, X. X. Wu, X. T. Zhang, Butrouna, K., V. S. Cao, Y. H. Zhang, Jiangping Hu, S. J. Yuan, Schlottmann, P., De Long, L. E., and G. Cao

Subjects
*SUPERCONDUCTIVITY, *ELECTRIC conductivity, *SINGLE crystals, *PARAMAGNETISM, *PHASE transitions
Abstract

We observe an unusual combination of normal and superconducting state properties without any signature of strong spin fluctuations in single-crystal Ir3Te8. The electrical resistivity does not saturate by 700 K but exhibits a low-resistivity ratio, and it exhibits two extended linear regimes (approximately 20-330 and 370-700 K) with the same slope, separated by a small hysteretic interval marking a strong first-order phase transition from cubic to rhombohedral lattice symmetry at Ts = 350 K. The electronic heat-capacity coefficient (11 mJ mol-1 K-2) is consistent with a net diamagnetic, rather than a Pauli paramagnetic, normal state that yields to superconductivity below a critical temperature Tc = 1.8 K. The size of the heat-capacity jump near Tc indicates bulk superconductivity. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

89. Identification of molecular subtypes for endometrial carcinoma using a 46-gene next-generation sequencing panel: a retrospective study on a consecutive cohort.

Author

Guo Q, Tang S, Ju X, Feng Z, Zhang Z, Peng D, Liu F, Du H, Wang J, Zhang Y, Wang G, Zhang Z, Cai S, Diao Y, Zhong Y, Wu X, Zhou X, and Wen H

Abstract

Background: Traditional classification tools for endometrial carcinoma (EC), such as DNA sequencing, immunohistochemistry (IHC), or PCR, are cumbersome and time-consuming. Large next-generation sequencing (NGS) panels have simplified testing but are expensive. In this study, we propose a concise NGS panel as an effectively viable approach for classifying EC., Materials and Methods: We retrospectively enrolled a consecutive EC cohort of hysterectomy with bilateral salpingo-oophorectomy from Fudan University Shanghai Cancer Center between 2020 and 2022. A 46-gene NGS panel was utilized to identify POLE exonuclease domain mutations, microsatellite instability-high (MSI-H), TP53 mutations, and other clinically relevant targets., Results: Tumor tissue samples from 331 EC patients were evaluated, with 284 (85.8%) cases classified as endometrioid endometrial carcinoma. The median follow-up time was 32.6 months (n = 303), during which 23 patients experienced recurrence or disease progression. Using the concise NGS panel, patients were stratified into four molecular subgroups according to the World Health Organization classification criteria: POLE mut (n = 47; 14.2%), mismatch repair deficiency (dMMR) (n = 79; 23.9%), non-specific molecular profile (n = 148; 44.7%), and abnormal p53 expression (p53 abn) (n = 57; 17.2%). POLE mut displayed the most favorable prognosis, while p53 abn had the worst prognosis (P < 0.001). The concordance between NGS and IHC was 91.8% (269/293) for detecting MMR status and 65.3% (201/308) for detecting p53 status. Patients detected solely by NGS had significantly worse prognosis than those detected solely by IHC, indicating higher accuracy of the NGS panel. With the molecular subtyping information, adjuvant treatment plans for 19.6% of patients could potentially be altered, mainly concentrated in the POLE mut and p53 abn subtypes. This panel also aids targeted therapy and poly (ADP-ribose) polymerase (PARP) inhibitor-related gene mutation detection, as well as auxiliary genetic screening., Conclusion: Our study demonstrates that the concise NGS panel is an effective 'one-stop' strategy for precisely classifying EC with high clinical availability., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Published
2024
Full Text
View/download PDF

90. A risk-prediction score about colorectal lesions based on the Chinese population of high-risk participants aged 50-65 years.

Author

Zhao X, Li H, Jin L, Xue J, Yao Y, Pang W, Liu X, Wang W, Han Q, Zhang B, Zhao X, Zhang Q, Wu X, Tan Z, Zhang X, Su X, and Zhang C

Subjects
Humans, Male, Female, Middle Aged, Aged, China epidemiology, Risk Assessment, Risk Factors, Early Detection of Cancer statistics & numerical data, Age Factors, East Asian People, Colorectal Neoplasms epidemiology, Colorectal Neoplasms diagnosis
Abstract

Objectives: The present study aims to develop an effective risk-prediction score (RPS) to improve screening efficiency and contribute to secondary prevention of colorectal cancer (CRC)., Study Design: Screening for colorectal lesions., Methods: 14,398 high-risk individuals aged 50-65 years were included. The baseline characteristics of participants with and without colorectal lesions (CL) were compared using a Chi-squared test. The overall population was randomly split into a training set and a test set in the ratio of 80% and 20%. One-factor and multifactor logistic regression analyses were performed in the training set to construct the RPS (scores of 0-9.62). Area under curve (AUC) was calculated as an estimate of predictive performance using the receiver-operating characteristic (ROC) curve in the test set., Results: In the study population, being male, advanced age, current or previous smoking, weekly alcohol consumption, high body mass index (BMI ≥24 kg/m 2 ), and previously detected colonic polyp were associated with higher risk of CL. Compared to the low-risk group (0-2.31 points), the ORs and 95% confidence intervals (CIs) for the moderate-risk group (2.31-3.85 points) and high-risk group (3.85-8.42 points) were 1.58 (1.44, 1.73) and 2.52 (2.30, 2.76), respectively. For every 1-point increase in score, participants had a 27% increased risk of CL (OR:1.27, 95% CI: 1.24, 1.30). For participants with CL predicted by RPS, the area under the working characteristic curve was 0.61 (P < 0.001)., Conclusion: Our RPS can quickly and efficiently identify multiple lesions of the colorectum. Combining RPS with existing screening strategies facilitates the identification of very high-risk individuals and may help to prevent CRC., (Copyright © 2024 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.)

Published
2024
Full Text
View/download PDF

91. Precise Measurement of Born Cross Sections for e^{+}e^{-}→DD[over ¯] at sqrt[s]=3.80-4.95  GeV.

Author

Ablikim M, Achasov MN, Adlarson P, Ai XC, Aliberti R, Amoroso A, An MR, An Q, Bai Y, Bakina O, Balossino I, Ban Y, Batozskaya V, Begzsuren K, Berger N, Berlowski M, Bertani M, Bettoni D, Bianchi F, Bianco E, Bortone A, Boyko I, Briere RA, Brueggemann A, Cai H, Cai X, Calcaterra A, Cao GF, Cao N, Cetin SA, Chang JF, Chang TT, Chang WL, Che GR, Chelkov G, Chen C, Chen C, Chen G, Chen HS, Chen ML, Chen SJ, Chen SL, Chen SM, Chen T, Chen XR, Chen XT, Chen YB, Chen YQ, Chen ZJ, Cheng WS, Choi SK, Chu X, Cibinetto G, Coen SC, Cossio F, Cui JJ, Dai HL, Dai JP, Dbeyssi A, de Boer RE, Dedovich D, Deng ZY, Denig A, Denysenko I, Destefanis M, De Mori F, Ding B, Ding XX, Ding Y, Ding Y, Dong J, Dong LY, Dong MY, Dong X, Du MC, Du SX, Duan ZH, Egorov P, Fan YH, Fang J, Fang SS, Fang WX, Fang Y, Farinelli R, Fava L, Feldbauer F, Felici G, Feng CQ, Feng JH, Fischer K, Fritsch M, Fu CD, Fu JL, Fu YW, Gao H, Gao YN, Gao Y, Garbolino S, Garzia I, Ge PT, Ge ZW, Geng C, Gersabeck EM, Gilman A, Goetzen K, Gong L, Gong WX, Gradl W, Gramigna S, Greco M, Gu MH, Gu YT, Guan CY, Guan ZL, Guo AQ, Guo LB, Guo MJ, Guo RP, Guo YP, Guskov A, Han TT, Han WY, Hao XQ, Harris FA, He KK, He KL, Heinsius FHH, Heinz CH, Heng YK, Herold C, Holtmann T, Hong PC, Hou GY, Hou XT, Hou YR, Hou ZL, Hu HM, Hu JF, Hu T, Hu Y, Huang GS, Huang KX, Huang LQ, Huang XT, Huang YP, Hussain T, Hüsken N, In der Wiesche N, Irshad M, Jackson J, Jaeger S, Janchiv S, Jeong JH, Ji Q, Ji QP, Ji XB, Ji XL, Ji YY, Jia XQ, Jia ZK, Jiang HJ, Jiang PC, Jiang SS, Jiang TJ, Jiang XS, Jiang Y, Jiao JB, Jiao Z, Jin S, Jin Y, Jing MQ, Johansson T, Kui X, Kabana S, Kalantar-Nayestanaki N, Kang XL, Kang XS, Kavatsyuk M, Ke BC, Khoukaz A, Kiuchi R, Kliemt R, Kolcu OB, Kopf B, Kuessner M, Kupsc A, Kühn W, Lane JJ, Larin P, Lavania A, Lavezzi L, Lei TT, Lei ZH, Leithoff H, Lellmann M, Lenz T, Li C, Li C, Li CH, Li C, Li DM, Li F, Li G, Li H, Li HB, Li HJ, Li HN, Li H, Li JR, Li JS, Li JW, Li KL, Li K, Li LJ, Li LK, Li L, Li MH, Li PR, Li QX, Li SX, Li T, Li WD, Li WG, Li XH, Li XL, Li X, Li YG, Li ZJ, Li ZX, Liang C, Liang H, Liang H, Liang H, Liang YF, Liang YT, Liao GR, Liao LZ, Liao YP, Libby J, Limphirat A, Lin DX, Lin T, Liu BJ, Liu BX, Liu C, Liu CX, Liu FH, Liu F, Liu F, Liu GM, Liu H, Liu HB, Liu HM, Liu H, Liu H, Liu JB, Liu JL, Liu JY, Liu K, Liu KY, Liu K, Liu L, Liu LC, Liu L, Liu MH, Liu PL, Liu Q, Liu SB, Liu T, Liu WK, Liu WM, Liu X, Liu Y, Liu Y, Liu YB, Liu ZA, Liu ZQ, Lou XC, Lu FX, Lu HJ, Lu JG, Lu XL, Lu Y, Lu YP, Lu ZH, Luo CL, Luo MX, Luo T, Luo XL, Lyu XR, Lyu YF, Ma FC, Ma HL, Ma JL, Ma LL, Ma MM, Ma QM, Ma RQ, Ma RT, Ma XY, Ma Y, Ma YM, Maas FE, Maggiora M, Malde S, Malik QA, Mangoni A, Mao YJ, Mao ZP, Marcello S, Meng ZX, Messchendorp JG, Mezzadri G, Miao H, Min TJ, Mitchell RE, Mo XH, Muchnoi NY, Muskalla J, Nefedov Y, Nerling F, Nikolaev IB, Ning Z, Nisar S, Niu QL, Niu WD, Niu Y, Olsen SL, Ouyang Q, Pacetti S, Pan X, Pan Y, Pathak A, Patteri P, Pei YP, Pelizaeus M, Peng HP, Peng YY, Peters K, Ping JL, Ping RG, Plura S, Prasad V, Qi FZ, Qi H, Qi HR, Qi M, Qi TY, Qian S, Qian WB, Qiao CF, Qin JJ, Qin LQ, Qin XP, Qin XS, Qin ZH, Qiu JF, Qu SQ, Redmer CF, Ren KJ, Rivetti A, Rolo M, Rong G, Rosner C, Ruan SN, Salone N, Sarantsev A, Schelhaas Y, Schoenning K, Scodeggio M, Shan KY, Shan W, Shan XY, Shangguan JF, Shao LG, Shao M, Shen CP, Shen HF, Shen WH, Shen XY, Shi BA, Shi HC, Shi JL, Shi JY, Shi QQ, Shi RS, Shi X, Song JJ, Song TZ, Song WM, Song YJ, Song YX, Sosio S, Spataro S, Stieler F, Su YJ, Sun GB, Sun GX, Sun H, Sun HK, Sun JF, Sun K, Sun L, Sun SS, Sun T, Sun WY, Sun Y, Sun YJ, Sun YZ, Sun ZT, Tan YX, Tang CJ, Tang GY, Tang J, Tang YA, Tao LY, Tao QT, Tat M, Teng JX, Thoren V, Tian WH, Tian WH, Tian Y, Tian ZF, Uman I, Wang SJ, Wang B, Wang BL, Wang B, Wang CW, Wang DY, Wang F, Wang HJ, Wang HP, Wang JP, Wang K, Wang LL, Wang M, Wang M, Wang S, Wang S, Wang T, Wang TJ, Wang W, Wang W, Wang WP, Wang X, Wang XF, Wang XJ, Wang XL, Wang Y, Wang YD, Wang YF, Wang YH, Wang YN, Wang YQ, Wang Y, Wang Y, Wang Z, Wang ZL, Wang ZY, Wang Z, Wei D, Wei DH, Weidner F, Wen SP, Wenzel CW, Wiedner U, Wilkinson G, Wolke M, Wollenberg L, Wu C, Wu JF, Wu LH, Wu LJ, Wu X, Wu XH, Wu Y, Wu YH, Wu YJ, Wu Z, Xia L, Xian XM, Xiang T, Xiao D, Xiao GY, Xiao SY, Xiao YL, Xiao ZJ, Xie C, Xie XH, Xie Y, Xie YG, Xie YH, Xie ZP, Xing TY, Xu CF, Xu CJ, Xu GF, Xu HY, Xu QJ, Xu QN, Xu W, Xu WL, Xu XP, Xu YC, Xu ZP, Xu ZS, Yan F, Yan L, Yan WB, Yan WC, Yan XQ, Yang HJ, Yang HL, Yang HX, Yang T, Yang Y, Yang YF, Yang YX, Yang Y, Yang ZW, Yao ZP, Ye M, Ye MH, Yin JH, You ZY, Yu BX, Yu CX, Yu G, Yu JS, Yu T, Yu XD, Yuan CZ, Yuan L, Yuan SC, Yuan XQ, Yuan Y, Yuan ZY, Yue CX, Zafar AA, Zeng FR, Zeng X, Zeng Y, Zeng YJ, Zhai XY, Zhai YC, Zhan YH, Zhang AQ, Zhang BL, Zhang BX, Zhang DH, Zhang GY, Zhang H, Zhang HC, Zhang HH, Zhang HH, Zhang HQ, Zhang HY, Zhang J, Zhang JJ, Zhang JL, Zhang JQ, Zhang JW, Zhang JX, Zhang JY, Zhang JZ, Zhang J, Zhang J, Zhang LM, Zhang LQ, Zhang L, Zhang P, Zhang QY, Zhang S, Zhang S, Zhang XD, Zhang XM, Zhang XY, Zhang X, Zhang Y, Zhang Y, Zhang YT, Zhang YH, Zhang Y, Zhang Y, Zhang ZH, Zhang ZL, Zhang ZY, Zhang ZY, Zhao G, Zhao J, Zhao JY, Zhao JZ, Zhao L, Zhao L, Zhao MG, Zhao SJ, Zhao YB, Zhao YX, Zhao ZG, Zhemchugov A, Zheng B, Zheng JP, Zheng WJ, Zheng YH, Zhong B, Zhong X, Zhou H, Zhou LP, Zhou X, Zhou XK, Zhou XR, Zhou XY, Zhou YZ, Zhu J, Zhu K, Zhu KJ, Zhu L, Zhu LX, Zhu SH, Zhu SQ, Zhu TJ, Zhu WJ, Zhu YC, Zhu ZA, Zou JH, and Zu J

Abstract

Using data samples collected with the BESIII detector at the BEPCII collider at center-of-mass energies ranging from 3.80 to 4.95 GeV, corresponding to an integrated luminosity of 20  fb^{-1}, a measurement of Born cross sections for the e^{+}e^{-}→D^{0}D[over ¯]^{0} and D^{+}D^{-} processes is presented with unprecedented precision. Many clear peaks in the line shape of e^{+}e^{-}→D^{0}D[over ¯]^{0} and D^{+}D^{-} around the mass range of G(3900), ψ(4040), ψ(4160), Y(4260), and ψ(4415), etc., are foreseen. These results offer crucial experimental insights into the nature of hadron production in the open-charm region.

Published
2024
Full Text
View/download PDF

92. [SUV3 knockdown inhibits proliferation, migration, and invasion of hepatocellular carcinoma cells and induces PD-L1 expression].

Author

Zhang JH, Wu X, Wang TT, and Wang ZS

Subjects
Humans, Cell Line, Tumor, Neoplasm Invasiveness, Gene Expression Regulation, Neoplastic, Liver Neoplasms metabolism, Liver Neoplasms pathology, Liver Neoplasms genetics, Cell Proliferation, Carcinoma, Hepatocellular metabolism, Carcinoma, Hepatocellular pathology, Carcinoma, Hepatocellular genetics, Cell Movement, B7-H1 Antigen metabolism, B7-H1 Antigen genetics
Abstract

Objective: To study the SUV3 gene role during the process of occurrence and advancement of hepatocellular carcinom. Methods: The The differences in SUV3 expression between hepatocellular carcinoma tissues and normal liver tissues were compared by analyzing transcriptome sequencing data from TCGA and GTEx databases. SUV3 knockdown in different hepatocellular carcinoma cells was performed using RNA interference technology. Overexpression vectors were constructed to overexpress SUV3 in different hepatocellular carcinoma cells. The SUV3 regulatory effect was studied on proliferation, migration, and invasion of hepatocellular carcinoma cells. A subcellular fraction isolation approach was used to investigate whether SUV3 knockdown resulted in the release of mitochondrial DNA into the cytoplasm. Quantitative reverse transcription PCR was applied to investigate whether SUV3 knockdown affected PD-L1 expression. The two groups were compared using a two-tailed t -test. Results: The TCGA database analysis revealed that SUV3 expression was higher in hepatocellular carcinoma tissues than in normal liver tissues, and the prognosis of patients with high SUV3 expression in hepatocellular carcinoma tissues was poor. The quantitative RT-PCR results showed that SUV3 expression was higher in hepatocellular carcinoma tissues than that in paracancerous liver tissue. The MTS assay showed that with SUV3 knockdown, the proliferation rate was significantly lower in hepatocellular carcinoma cells than that of the control hepatocellular carcinoma cells ( P <0.01). The proliferation rate was significantly higher in SUV3-overexpressed hepatocellular carcinoma cells than that of control hepatocellular carcinoma cells ( P <0.01). Cell scratch assay and cell migration and invasion assay showed that SUV3 knockdown inhibited the migration and invasion of hepatocellular carcinoma cells ( P <0.01), while SUV3 overexpression promoted the migration and invasion of hepatocellular carcinoma cells ( P <0.05). SUV3 Knockdown led to a decrease in the overall level of mtDNA ( P <0.01) in accompanied by an increase in mtDNA level in the cytoplasm ( P <0.01), indicating that SUV3 knockdown led to mitochondrial DNA leakage into the cytoplasm. SUV3 knockdown resulted in elevated PD-L1 expression ( P <0.001), and overexpression of TREX1 in SUV3 knockdown cells decreased mtDNA levels in the cytoplasm and inhibited SUV3 knockdown, resulting in elevated PD-L1 expression, indicating that SUV3 knockdown induced PD-L1 expression by increasing cytoplasmic DNA levels. Conclusions: The SUV3 gene may play an oncogenic function in hepatocellular carcinoma cells.

Published
2024
Full Text
View/download PDF

93. [Swertiamarin ameliorates 2, 4, 6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting intestinal epithelial cell apoptosis].

Author

Liu S, Li J, and Wu X

Subjects
Animals, Mice, Humans, Caco-2 Cells, Intestinal Mucosa drug effects, Intestinal Mucosa metabolism, Phosphatidylinositol 3-Kinases metabolism, Disease Models, Animal, Proto-Oncogene Proteins c-akt metabolism, Iridoid Glucosides pharmacology, Signal Transduction drug effects, Caspase 3 metabolism, Trinitrobenzenesulfonic Acid, Colitis chemically induced, Colitis drug therapy, Colitis metabolism, Apoptosis drug effects, Tumor Necrosis Factor-alpha metabolism, Epithelial Cells metabolism, Epithelial Cells drug effects
Abstract

Objective: To investigate the mechanism by which swertiamarin (STM) ameliorates CD-like colitis in mice., Methods: A Caco-2 cell model of TNF- α -stimulated apoptosis was established and divided into three groups: Con, TNF- α and STM, and the effects of STM on apoptosis and barrier function were assessed by Tunel staining, western blotting, immunofluorescence, and transepithelial electric resistance (TEER). A mouse model of 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) -induced CD-like colitis was established to assess the effects of STM on colitis, intestinal barrier function and epithelial cell apoptosis. The regulatory role of the PI3K/AKT pathway in STM-induced resistance to intestinal epithelial cell apoptosis was investigated in both the cell model and mouse models., Results: TUNEL staining showed that in Caco-2 cells with TNF- α stimulation, STM treatment significantly reduced the percentage of TUNEL-stained cells ( P <0.05). STM obviously reduced TNF- α -induced enhancement of cleaved-caspase 3 and Bax expressions ( P <0.05), increased Bcl-2 expression ( P <0.05), protected intestinal barrier integrity and function by restoring transepithelial electrical resistance (TEER) of the cells, promoted normal localization and expressions of the tight junction proteins (ZO1 and claudin 1) ( P <0.05), and inhibited the expression of pro-inflammatory factors (IL-6 and CCL3) ( P <0.05) in TNF- α -stimulated Caco-2 cells. In the mouse models, STM significantly alleviated TNBS-induced CD-like colitis and intestinal barrier dysfunction ( P <0.05) as shown by improved weight loss, lowered Disease Activity Index (DAI) score and inflammation score, reduction of IL-6 and CCL3 release, and restoration of intestinal barrier permeability, colonic TEER, bacterial translocation, and localization and expressions of the tight junction proteins. Mechanistically, STM inhibited the expressions of p-PI3K and p-AKT in both the cell model and mouse model( P <0.05), and treatment with 740Y-P (a PI3K/AKT pathway activator) significantly attenuated the inhibitory effect of STM on TNF- α -induced apoptosis in Caco-2 cells ( P <0.05)., Conclusion: STM inhibits intestinal epithelial cell apoptosis at least in part by suppressing activation of the PI3K/AKT pathway to ameliorate intestinal barrier dysfunction and colitis in mice.

Published
2024
Full Text
View/download PDF

94. Observation of Strong Nuclear Suppression in Exclusive J/ψ Photoproduction in Au+Au Ultraperipheral Collisions at RHIC.

Author

Abdulhamid MI, Aboona BE, Adam J, Adamczyk L, Adams JR, Aggarwal I, Aggarwal MM, Ahammed Z, Aschenauer EC, Aslam S, Atchison J, Bairathi V, Cap JGB, Barish K, Bellwied R, Bhagat P, Bhasin A, Bhatta S, Bhosale SR, Bielcik J, Bielcikova J, Brandenburg JD, Broodo C, Cai XZ, Caines H, Sánchez MCB, Cebra D, Ceska J, Chakaberia I, Chaloupka P, Chan BK, Chang Z, Chatterjee A, Chen D, Chen J, Chen JH, Chen Z, Cheng J, Cheng Y, Choudhury S, Christie W, Chu X, Crawford HJ, Csanád M, Dale-Gau G, Das A, Deppner IM, Dhamija A, Dixit P, Dong X, Drachenberg JL, Duckworth E, Dunlop JC, Engelage J, Eppley G, Esumi S, Evdokimov O, Eyser O, Fatemi R, Fazio S, Feng CJ, Feng Y, Finch E, Fisyak Y, Flor FA, Fu C, Gagliardi CA, Galatyuk T, Gao T, Geurts F, Ghimire N, Gibson A, Gopal K, Gou X, Grosnick D, Gupta A, Guryn W, Hamed A, Han Y, Harabasz S, Harasty MD, Harris JW, Harrison-Smith H, He W, He XH, He Y, Herrmann N, Holub L, Hu C, Hu Q, Hu Y, Huang H, Huang HZ, Huang SL, Huang T, Huang X, Huang Y, Huang Y, Humanic TJ, Isshiki M, Jacobs WW, Jalotra A, Jena C, Jentsch A, Ji Y, Jia J, Jin C, Ju X, Judd EG, Kabana S, Kalinkin D, Kang K, Kapukchyan D, Kauder K, Keane D, Khanal A, Khyzhniak YV, Kikoła DP, Kincses D, Kisel I, Kiselev A, Knospe AG, Ko HS, Kosarzewski LK, Kumar L, Labonte MC, Lacey R, Landgraf JM, Lauret J, Lebedev A, Lee JH, Leung YH, Lewis N, Li C, Li D, Li HS, Li H, Li W, Li X, Li Y, Li Y, Li Z, Liang X, Liang Y, Licenik R, Lin T, Lin Y, Lisa MA, Liu C, Liu G, Liu H, Liu L, Liu T, Liu X, Liu Y, Liu Z, Ljubicic T, Lomicky O, Longacre RS, Loyd EM, Lu T, Luo J, Luo XF, Ma L, Ma R, Ma YG, Magdy N, Mallick D, Manikandhan R, Margetis S, Markert C, McNamara G, Mezhanska O, Mi K, Mioduszewski S, Mohanty B, Mondal MM, Mooney I, Mrazkova J, Nagy MI, Nain AS, Nam JD, Nasim M, Neff D, Nelson JM, Nemes DB, Nie M, Nigmatkulov G, Niida T, Nonaka T, Odyniec G, Ogawa A, Oh S, Okubo K, Page BS, Pak R, Pal S, Pandav A, Pandey AK, Pani T, Paul A, Pawlik B, Pawlowska D, Perkins C, Pluta J, Pokhrel BR, Posik M, Protzman T, Prozorova V, Pruthi NK, Przybycien M, Putschke J, Qin Z, Qiu H, Racz C, Radhakrishnan SK, Rana A, Ray RL, Reed R, Robertson CW, Robotkova M, Aguilar MAR, Roy D, Chowdhury PR, Ruan L, Sahoo AK, Sahoo NR, Sako H, Salur S, Sato S, Schaefer BC, Schmidke WB, Schmitz N, Seck FJ, Seger J, Seto R, Seyboth P, Shah N, Shanmuganathan PV, Shao T, Sharma M, Sharma N, Sharma R, Sharma SR, Sheikh AI, Shen D, Shen DY, Shen K, Shi SS, Shi Y, Shou QY, Si F, Singh J, Singha S, Sinha P, Skoby MJ, Smirnov N, Söhngen Y, Song Y, Srivastava B, Stanislaus TDS, Stefaniak M, Stewart DJ, Su Y, Sumbera M, Sun C, Sun X, Sun Y, Sun Y, Surrow B, Svoboda M, Sweger ZW, Tamis AC, Tang AH, Tang Z, Tarnowsky T, Thomas JH, Timmins AR, Tlusty D, Todoroki T, Trentalange S, Tribedy P, Tripathy SK, Truhlar T, Trzeciak BA, Tsai OD, Tsang CY, Tu Z, Tyler J, Ullrich T, Underwood DG, Upsal I, Van Buren G, Vanek J, Vassiliev I, Verkest V, Videbæk F, Voloshin SA, Wang F, Wang G, Wang JS, Wang J, Wang K, Wang X, Wang Y, Wang Y, Wang Y, Wang Z, Webb JC, Weidenkaff PC, Westfall GD, Wielanek D, Wieman H, Wilks G, Wissink SW, Witt R, Wu J, Wu J, Wu X, Wu X, Xi B, Xiao ZG, Xie G, Xie W, Xu H, Xu N, Xu QH, Xu Y, Xu Y, Xu Z, Xu Z, Yan G, Yan Z, Yang C, Yang Q, Yang S, Yang Y, Ye Z, Ye Z, Yi L, Yip K, Yu Y, Zbroszczyk H, Zha W, Zhang C, Zhang D, Zhang J, Zhang S, Zhang W, Zhang X, Zhang Y, Zhang Y, Zhang Y, Zhang Y, Zhang ZJ, Zhang Z, Zhang Z, Zhao F, Zhao J, Zhao M, Zhou J, Zhou S, Zhou Y, Zhu X, Zurek M, and Zyzak M

Abstract

We report a measurement of exclusive J/ψ and ψ(2s) photoproduction in Au+Au ultraperipheral collisions at sqrt[s&#95;{NN}]=200  GeV using the STAR detector. For the first time, (i) the ψ(2s) photoproduction in midrapidity at the Relativistic Heavy-Ion Collider has been experimentally measured; (ii) nuclear suppression factors are measured for both the coherent and incoherent J/ψ production. At average photon-nucleon center-of-mass energy of 25.0 GeV, the coherent and incoherent J/ψ cross sections of Au nuclei are found to be 71±10% and 36±7%, respectively, of that of free protons. The stronger suppression observed in the incoherent production provides a new experimental handle to study the initial-state parton density in heavy nuclei. Data are compared with theoretical models quantitatively.

Published
2024
Full Text
View/download PDF

95. Detecting pulmonary malignancy against benign nodules using noninvasive cell-free DNA fragmentomics assay.

Author

Xu S, Luo J, Tang W, Bao H, Wang J, Chang S, Zou Z, Fan X, Liu Y, Jiang C, and Wu X

Subjects
Humans, Female, Male, Middle Aged, Aged, Multiple Pulmonary Nodules diagnostic imaging, Liquid Biopsy methods, Early Detection of Cancer methods, Tomography, X-Ray Computed methods, Carcinoma, Non-Small-Cell Lung genetics, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Non-Small-Cell Lung diagnosis, Lung Neoplasms genetics, Lung Neoplasms diagnosis, Lung Neoplasms pathology, Cell-Free Nucleic Acids, Machine Learning
Abstract

Background: Early screening using low-dose computed tomography (LDCT) can reduce mortality caused by non-small-cell lung cancer. However, ∼25% of the 'suspicious' pulmonary nodules identified by LDCT are later confirmed benign through resection surgery, adding to patients' discomfort and the burden on the healthcare system. In this study, we aim to develop a noninvasive liquid biopsy assay for distinguishing pulmonary malignancy from benign yet 'suspicious' lung nodules using cell-free DNA (cfDNA) fragmentomics profiling., Methods: An independent training cohort consisting of 193 patients with malignant nodules and 44 patients with benign nodules was used to construct a machine learning model. Base models using four different fragmentomics profiles were optimized using an automated machine learning approach before being stacked into the final predictive model. An independent validation cohort, including 96 malignant nodules and 22 benign nodules, and an external test cohort, including 58 malignant nodules and 41 benign nodules, were used to assess the performance of the stacked ensemble model., Results: Our machine learning models demonstrated excellent performance in detecting patients with malignant nodules. The area under the curves reached 0.857 and 0.860 in the independent validation cohort and the external test cohort, respectively. The validation cohort achieved an excellent specificity (68.2%) at the targeted 90% sensitivity (89.6%). An equivalently good performance was observed while applying the cut-off to the external cohort, which reached a specificity of 63.4% at 89.7% sensitivity. A subgroup analysis for the independent validation cohort showed that the sensitivities for detecting various subgroups of nodule size (<1 cm: 91.7%; 1-3 cm: 88.1%; >3 cm: 100%; unknown: 100%) and smoking history (yes: 88.2%; no: 89.9%) all remained high among the lung cancer group., Conclusions: Our cfDNA fragmentomics assay can provide a noninvasive approach to distinguishing malignant nodules from radiographically suspicious but pathologically benign ones, amending LDCT false positives., Competing Interests: Disclosure WT, HB, SC, and XW are employees of Nanjing Geneseeq Technology Inc., Nanjing, Jiangsu, China. The remaining authors have declared no conflicts of interest., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2024
Full Text
View/download PDF

96. Antimicrobial-coated sutures versus non-coated sutures in reducing surgical site infection: an updated systematic review and meta-analysis.

Author

Yang Y, Zhou Z, Ma R, Ren J, and Wu X

Subjects
Humans, Anti-Infective Agents administration & dosage, Randomized Controlled Trials as Topic, Coated Materials, Biocompatible, Surgical Wound Infection prevention & control, Sutures microbiology
Abstract

Background: Antimicrobial-coated sutures are one of the strategies to avoid surgical site infection (SSI) caused by microbial colonization on the surface of surgical sutures., Aim: To investigate the effectiveness of antimicrobial-coated sutures in reducing SSI and develop the latest systematic evaluation evidence for clinical SSI prevention and the use of antimicrobial-coated sutures., Methods: The databases of MEDLINE, Embase, CINAHL, Cochrane, African Index Medicus, and WHO Global Health were searched from October 10 th , 1990 to March 3 rd , 2023 with language restricted to English, Spanish, and French. Meta-analysis was used to evaluate the impact of antimicrobial-coated sutures on SSI and whether their effectiveness is influenced by the type of sutures or wounds. Subgroup analyses were conducted based on type of sutures and wounds. Finally, quality of the retrieved evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE)., Findings: Twenty-six randomized control trials (RCTs) and nine observational studies (OBSs) met the inclusion criteria. Antimicrobial sutures significantly reduced SSI risk (RCTs: odds ratio: 0.74; 95% confidence interval: 0.63-0.87; P = 0.0002; OBSs: OR: 0.61; 95% CI: 0.48-0.76; P < 0.0001). Only subgroup analysis of Polydioxanone Suture (PDS) Plus vs PDS, Vicryl Plus vs Vicryl and mixed wounds revealed consistent results in favour of antimicrobial-coated sutures. According to GRADE, the quality of RCT evidence is moderate, while that of OBS evidence is low., Conclusion: Antimicrobial-coated sutures are effective in reducing the risk of postoperative SSI among a large number of surgical patients. However, the available evidence is of moderate/low quality and many studies had conflicts of interest., (Copyright © 2024 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.)

Published
2024
Full Text
View/download PDF

97. [3-Methyladenine alleviates early renal injury in diabetic mice by inhibiting AKT signaling].

Author

Liu B, Wang Y, Ren H, Ou L, Deng X, Huang M, Wu X, and Gong Q

Subjects
Animals, Mice, Kidney pathology, Kidney metabolism, Kidney drug effects, Male, Blood Glucose metabolism, Cell Proliferation drug effects, Diabetes Mellitus, Experimental metabolism, Proto-Oncogene Proteins c-akt metabolism, Diabetic Nephropathies metabolism, Diabetic Nephropathies drug therapy, Signal Transduction drug effects, Adenine analogs & derivatives, Adenine pharmacology
Abstract

Objective: To explore the mechanism of 3-methyladenine (3-MA) for alleviating early diabetic renal injury., Methods: Mouse models of streptozotocin (STZ) -induced diabetes mellitus were randomized into model group and 3-MA treatment group for daily treatments with normal saline and 10 mg/kg 3-MA by gavage for 6 weeks, respectively. Body weight and fasting blood glucose of the mice were recorded every week. After the treatments, the kidneys of the mice were collected for measurement kidney/body weight ratio, examination of glomerular size with PAS staining, and detection of α -SMA and PCNA expressions using Western blotting and immunohistochemistry. SV40 MES 13 cells cultured in normal glucose (5.6 mmol/L) and high glucose (30 mmol/L) were treated with 24.4 mmol/L mannitol and 5 mmol/L 3-MA for 24 h, respectively, and the changes in cell viability and PCNA expression were examined using CCK8 assay and Western blotting. Bioinformatics analysis of the intersecting gene targets of diabetic kidney disease (DKD) and 3-MA was performed, and the results were verified by Western blotting both in vivo and in vitro ., Results: In the diabetic mice, treatment with 3-MA produced a short-term hypoglycemic effect, reduced the kidney/body weight ratio and glomerular hypertrophy, and decreased the expressions of α ‑SMA and PCNA in the renal cortex. In the in vitro study, 3-MA significantly lowered the viability and reduced PCNA expression in SV40 MES 13 cells exposed to high glucose. The results of bioinformatic analysis identified AKT1 as the key gene in the therapeutic mechanism of 3-MA for DKD. Western blotting confirmed that 3-MA inhibited the phosphorylation of AKT and S6 in both the renal cortex of diabetic mice and high glucose-treated SV40 MES 13 cells., Conclusion: 3-MA suppresses mesangial cell proliferation and alleviates early diabetic renal injury in mice possibly by inhibiting AKT signaling.

Published
2024
Full Text
View/download PDF

98. Statistical Combination of ATLAS Run 2 Searches for Charginos and Neutralinos at the LHC.

Author

Aad G, Abbott B, Abeling K, Abicht NJ, Abidi SH, Aboulhorma A, Abramowicz H, Abreu H, Abulaiti Y, Acharya BS, Adam Bourdarios C, Adamczyk L, Addepalli SV, Addison MJ, Adelman J, Adiguzel A, Adye T, Affolder AA, Afik Y, Agaras MN, Agarwala J, Aggarwal A, Agheorghiesei C, Ahmad A, Ahmadov F, Ahmed WS, Ahuja S, Ai X, Aielli G, Aikot A, Ait Tamlihat M, Aitbenchikh B, Aizenberg I, Akbiyik M, Åkesson TPA, Akimov AV, Akiyama D, Akolkar NN, Aktas S, Al Khoury K, Alberghi GL, Albert J, Albicocco P, Albouy GL, Alderweireldt S, Alegria ZL, Aleksa M, Aleksandrov IN, Alexa C, Alexopoulos T, Alfonsi F, Algren M, Alhroob M, Ali B, Ali HMJ, Ali S, Alibocus SW, Aliev M, Alimonti G, Alkakhi W, Allaire C, Allbrooke BMM, Allen JF, Allendes Flores CA, Allport PP, Aloisio A, Alonso F, Alpigiani C, Alvarez Estevez M, Alvarez Fernandez A, Alves Cardoso M, Alviggi MG, Aly M, Amaral Coutinho Y, Ambler A, Amelung C, Amerl M, Ames CG, Amidei D, Amor Dos Santos SP, Amos KR, Ananiev V, Anastopoulos C, Andeen T, Anders JK, Andrean SY, Andreazza A, Angelidakis S, Angerami A, Anisenkov AV, Annovi A, Antel C, Anthony MT, Antipov E, Antonelli M, Anulli F, Aoki M, Aoki T, Aparisi Pozo JA, Aparo MA, Aperio Bella L, Appelt C, Apyan A, Aranzabal N, Arbiol Val SJ, Arcangeletti C, Arce ATH, Arena E, Arguin JF, Argyropoulos S, Arling JH, Arnaez O, Arnold H, Artoni G, Asada H, Asai K, Asai S, Asbah NA, Assamagan K, Astalos R, Atashi S, Atkin RJ, Atkinson M, Atmani H, Atmasiddha PA, Augsten K, Auricchio S, Auriol AD, Austrup VA, Avolio G, Axiotis K, Azuelos G, Babal D, Bachacou H, Bachas K, Bachiu A, Backman F, Badea A, Baer TM, Bagnaia P, Bahmani M, Bahner D, Bailey AJ, Bailey VR, Baines JT, Baines L, Baker OK, Bakos E, Bakshi Gupta D, Balakrishnan V, Balasubramanian R, Baldin EM, Balek P, Ballabene E, Balli F, Baltes LM, Balunas WK, Balz J, Banas E, Bandieramonte M, Bandyopadhyay A, Bansal S, Barak L, Barakat M, Barberio EL, Barberis D, Barbero M, Barel MZ, Barends KN, Barillari T, Barisits MS, Barklow T, Baron P, Baron Moreno DA, Baroncelli A, Barone G, Barr AJ, Barr JD, Barranco Navarro L, Barreiro F, Barreiro Guimarães da Costa J, Barron U, Barros Teixeira MG, Barsov S, Bartels F, Bartoldus R, Barton AE, Bartos P, Basan A, Baselga M, Bassalat A, Basso MJ, Basson CR, Bates RL, Batlamous S, Batley JR, Batool B, Battaglia M, Battulga D, Bauce M, Bauer M, Bauer P, Bazzano Hurrell LT, Beacham JB, Beau T, Beaucamp JY, Beauchemin PH, Becherer F, Bechtle P, Beck HP, Becker K, Beddall AJ, Bednyakov VA, Bee CP, Beemster LJ, Beermann TA, Begalli M, Begel M, Behera A, Behr JK, Beirer JF, Beisiegel F, Belfkir M, Bella G, Bellagamba L, Bellerive A, Bellos P, Beloborodov K, Benchekroun D, Bendebba F, Benhammou Y, Benoit M, Bensinger JR, Bentvelsen S, Beresford L, Beretta M, Bergeaas Kuutmann E, Berger N, Bergmann B, Beringer J, Bernardi G, Bernius C, Bernlochner FU, Bernon F, Berrocal Guardia A, Berry T, Berta P, Berthold A, Bertram IA, Bethke S, Betti A, Bevan AJ, Bhalla NK, Bhamjee M, Bhatta S, Bhattacharya DS, Bhattarai P, Bhopatkar VS, Bi R, Bianchi RM, Bianco G, Biebel O, Bielski R, Biglietti M, Bindi M, Bingul A, Bini C, Biondini A, Birch-Sykes CJ, Bird GA, Birman M, Biros M, Biryukov S, Bisanz T, Bisceglie E, Biswal JP, Biswas D, Bitadze A, Bjørke K, Bloch I, Blue A, Blumenschein U, Blumenthal J, Bobbink GJ, Bobrovnikov VS, Boehler M, Boehm B, Bogavac D, Bogdanchikov AG, Bohm C, Boisvert V, Bokan P, Bold T, Bomben M, Bona M, Boonekamp M, Booth CD, Borbély AG, Bordulev IS, Borecka-Bielska HM, Borissov G, Bortoletto D, Boscherini D, Bosman M, Bossio Sola JD, Bouaouda K, Bouchhar N, Boudreau J, Bouhova-Thacker EV, Boumediene D, Bouquet R, Boveia A, Boyd J, Boye D, Boyko IR, Bracinik J, Brahimi N, Brandt G, Brandt O, Braren F, Brau B, Brau JE, Brener R, Brenner L, Brenner R, Bressler S, Britton D, Britzger D, Brock I, Brooijmans G, Brooks WK, Brost E, Brown LM, Bruce LE, Bruckler TL, Bruckman de Renstrom PA, Brüers B, Bruni A, Bruni G, Bruschi M, Bruscino N, Buanes T, Buat Q, Buchin D, Buckley AG, Bulekov O, Bullard BA, Burdin S, Burgard CD, Burger AM, Burghgrave B, Burlayenko O, Burr JTP, Burton CD, Burzynski JC, Busch EL, Büscher V, Bussey PJ, Butler JM, Buttar CM, Butterworth JM, Buttinger W, Buxo Vazquez CJ, Buzykaev AR, Cabrera Urbán S, Cadamuro L, Caforio D, Cai H, Cai Y, Cai Y, Cairo VMM, Cakir O, Calace N, Calafiura P, Calderini G, Calfayan P, Callea G, Caloba LP, Calvet D, Calvet S, Calvet TP, Calvetti M, Camacho Toro R, Camarda S, Camarero Munoz D, Camarri P, Camerlingo MT, Cameron D, Camincher C, Campanelli M, Camplani A, Canale V, Canesse A, Cantero J, Cao Y, Capocasa F, Capua M, Carbone A, Cardarelli R, Cardenas JCJ, Cardillo F, Carducci G, Carli T, Carlino G, Carlotto JI, Carlson BT, Carlson EM, Carminati L, Carnelli A, Carnesale M, Caron S, Carquin E, Carrá S, Carratta G, Carrio Argos F, Carter JWS, Carter TM, Casado MP, Caspar M, Castillo FL, Castillo Garcia L, Castillo Gimenez V, Castro NF, Catinaccio A, Catmore JR, Cavaliere V, Cavalli N, Cavasinni V, Cekmecelioglu YC, Celebi E, Celli F, Centonze MS, Cepaitis V, Cerny K, Cerqueira AS, Cerri A, Cerrito L, Cerutti F, Cervato B, Cervelli A, Cesarini G, Cetin SA, Chakraborty D, Chan J, Chan WY, Chapman JD, Chapon E, Chargeishvili B, Charlton DG, Chatterjee M, Chauhan C, Chekanov S, Chekulaev SV, Chelkov GA, Chen A, Chen B, Chen B, Chen H, Chen H, Chen J, Chen J, Chen M, Chen S, Chen SJ, Chen X, Chen X, Chen Y, Cheng CL, Cheng HC, Cheong S, Cheplakov A, Cheremushkina E, Cherepanova E, Cherkaoui El Moursli R, Cheu E, Cheung K, Chevalier L, Chiarella V, Chiarelli G, Chiedde N, Chiodini G, Chisholm AS, Chitan A, Chitishvili M, Chizhov MV, Choi K, Chomont AR, Chou Y, Chow EYS, Chowdhury T, Chu KL, Chu MC, Chu X, Chudoba J, Chwastowski JJ, Cieri D, Ciesla KM, Cindro V, Ciocio A, Cirotto F, Citron ZH, Citterio M, Ciubotaru DA, Clark A, Clark PJ, Clarry C, Clavijo Columbie JM, Clawson SE, Clement C, Clercx J, Coadou Y, Cobal M, Coccaro A, Barrue RFC, Coelho Lopes De Sa R, Coelli S, Coimbra AEC, Cole B, Collot J, Conde Muiño P, Connell MP, Connell SH, Connelly IA, Conroy EI, Conventi F, Cooke HG, Cooper-Sarkar AM, Cordeiro Oudot Choi A, Corpe LD, Corradi M, Corriveau F, Cortes-Gonzalez A, Costa MJ, Costanza F, Costanzo D, Cote BM, Cowan G, Cranmer K, Cremonini D, Crépé-Renaudin S, Crescioli F, Cristinziani M, Cristoforetti M, Croft V, Crosby JE, Crosetti G, Cueto A, Cuhadar Donszelmann T, Cui H, Cui Z, Cunningham WR, Curcio F, Czodrowski P, Czurylo MM, De Sousa MJDCS, Da Fonseca Pinto JV, Da Via C, Dabrowski W, Dado T, Dahbi S, Dai T, Dal Santo D, Dallapiccola C, Dam M, D'amen G, D'Amico V, Damp J, Dandoy JR, Daneri MF, Danninger M, Dao V, Darbo G, Darmora S, Das SJ, D'Auria S, David C, Davidek T, Davis-Purcell B, Dawson I, Day-Hall HA, De K, De Asmundis R, De Biase N, De Castro S, De Groot N, de Jong P, De la Torre H, De Maria A, De Salvo A, De Sanctis U, De Santis F, De Santo A, De Vivie De Regie JB, Dedovich DV, Degens J, Deiana AM, Del Corso F, Del Peso J, Del Rio F, Delagrange L, Deliot F, Delitzsch CM, Della Pietra M, Della Volpe D, Dell'Acqua A, Dell'Asta L, Delmastro M, Delsart PA, Demers S, Demichev M, Denisov SP, D'Eramo L, Derendarz D, Derue F, Dervan P, Desch K, Deutsch C, Di Bello FA, Di Ciaccio A, Di Ciaccio L, Di Domenico A, Di Donato C, Di Girolamo A, Di Gregorio G, Di Luca A, Di Micco B, Di Nardo R, Diaconu C, Diamantopoulou M, Dias FA, Vale TDD, Diaz MA, Diaz Capriles FG, Didenko M, Diehl EB, Diehl L, Díez Cornell S, Diez Pardos C, Dimitriadi C, Dimitrievska A, Dingfelder J, Dinu IM, Dittmeier SJ, Dittus F, Djama F, Djobava T, Djuvsland JI, Doglioni C, Dohnalova A, Dolejsi J, Dolezal Z, Dona KM, Donadelli M, Dong B, Donini J, D'Onofrio A, D'Onofrio M, Dopke J, Doria A, Dos Santos Fernandes N, Dougan P, Dova MT, Doyle AT, Draguet MA, Dreyer E, Drivas-Koulouris I, Drnevich M, Drobac AS, Drozdova M, Du D, du Pree TA, Dubinin F, Dubovsky M, Duchovni E, Duckeck G, Ducu OA, Duda D, Dudarev A, Duden ER, D'uffizi M, Duflot L, Dührssen M, Dülsen C, Dumitriu AE, Dunford M, Dungs S, Dunne K, Duperrin A, Yildiz HD, Düren M, Durglishvili A, Dwyer BL, Dyckes GI, Dyndal M, Dziedzic BS, Earnshaw ZO, Eberwein GH, Eckerova B, Eggebrecht S, Purcino De Souza EE, Ehrke LF, Eigen G, Einsweiler K, Ekelof T, Ekman PA, El Farkh S, El Ghazali Y, El Jarrari H, El Moussaouy A, Ellajosyula V, Ellert M, Ellinghaus F, Ellis N, Elmsheuser J, Elsing M, Emeliyanov D, Enari Y, Ene I, Epari S, Erdmann J, Erland PA, Errenst M, Escalier M, Escobar C, Etzion E, Evans G, Evans H, Evans LS, Evans MO, Ezhilov A, Ezzarqtouni S, Fabbri F, Fabbri L, Facini G, Fadeyev V, Fakhrutdinov RM, Fakoudis D, Falciano S, Falda Ulhoa Coelho LF, Falke PJ, Faltova J, Fan C, Fan Y, Fang Y, Fanti M, Faraj M, Farazpay Z, Farbin A, Farilla A, Farooque T, Farrington SM, Fassi F, Fassouliotis D, Faucci Giannelli M, Fawcett WJ, Fayard L, Federic P, Federicova P, Fedin OL, Fedotov G, Feickert M, Feligioni L, Fellers DE, Feng C, Feng M, Feng Z, Fenton MJ, Fenyuk AB, Ferencz L, Ferguson RAM, Fernandez Luengo SI, Fernandez Martinez P, Fernoux MJV, Ferrando J, Ferrari A, Ferrari P, Ferrari R, Ferrere D, Ferretti C, Fiedler F, Fiedler P, Filipčič A, Filmer EK, Filthaut F, Fiolhais MCN, Fiorini L, Fisher WC, Fitschen T, Fitzhugh PM, Fleck I, Fleischmann P, Flick T, Flores M, Flores Castillo LR, Flores Sanz De Acedo L, Follega FM, Fomin N, Foo JH, Forland BC, Formica A, Forti AC, Fortin E, Fortman AW, Foti MG, Fountas L, Fournier D, Fox H, Francavilla P, Francescato S, Franchellucci S, Franchini M, Franchino S, Francis D, Franco L, Franco Lima V, Franconi L, Franklin M, Frattari G, Freegard AC, Freund WS, Frid YY, Friend J, Fritzsche N, Froch A, Froidevaux D, Frost JA, Fu Y, Fuenzalida Garrido S, Fujimoto M, Fung KY, De Simas Filho EF, Furukawa M, Fuster J, Gabrielli A, Gabrielli A, Gadow P, Gagliardi G, Gagnon LG, Gallas EJ, Gallop BJ, Gan KK, Ganguly S, Gao Y, Garay Walls FM, Garcia B, García C, Garcia Alonso A, Garcia Caffaro AG, García Navarro JE, Garcia-Sciveres M, Gardner GL, Gardner RW, Garelli N, Garg D, Garg RB, Gargan JM, Garner CA, Garvey CM, Gaspar P, Gassmann VK, Gaudio G, Gautam V, Gauzzi P, Gavrilenko IL, Gavrilyuk A, Gay C, Gaycken G, Gazis EN, Geanta AA, Gee CM, Gekow A, Gemme C, Genest MH, Gentile S, Gentry AD, George S, George WF, Geralis T, Gessinger-Befurt P, Geyik ME, Ghani M, Ghneimat M, Ghorbanian K, Ghosal A, Ghosh A, Ghosh A, Giacobbe B, Giagu S, Giani T, Giannetti P, Giannini A, Gibson SM, Gignac M, Gil DT, Gilbert AK, Gilbert BJ, Gillberg D, Gilles G, Gillwald NEK, Ginabat L, Gingrich DM, Giordani MP, Giraud PF, Giugliarelli G, Giugni D, Giuli F, Gkialas I, Gladilin LK, Glasman C, Gledhill GR, Glemža G, Glisic M, Gnesi I, Go Y, Goblirsch-Kolb M, Gocke B, Godin D, Gokturk B, Goldfarb S, Golling T, Gololo MGD, Golubkov D, Gombas JP, Gomes A, Gomes Da Silva G, Gomez Delegido AJ, Gonçalo R, Gonella G, Gonella L, Gongadze A, Gonnella F, Gonski JL, González Andana RY, González de la Hoz S, Gonzalez Fernandez S, Gonzalez Lopez R, Gonzalez Renteria C, Gonzalez Rodrigues MV, Gonzalez Suarez R, Gonzalez-Sevilla S, Gonzalvo Rodriguez GR, Goossens L, Gorini B, Gorini E, Gorišek A, Gosart TC, Goshaw AT, Gostkin MI, Goswami S, Gottardo CA, Gotz SA, Gouighri M, Goumarre V, Goussiou AG, Govender N, Grabowska-Bold I, Graham K, Gramstad E, Grancagnolo S, Grandi M, Grant CM, Gravila PM, Gravili FG, Gray HM, Greco M, Grefe C, Gregor IM, Grenier P, Grewe SG, Grieco C, Grillo AA, Grimm K, Grinstein S, Grivaz JF, Gross E, Grosse-Knetter J, Grud C, Grundy JC, Guan L, Guan W, Gubbels C, Guerrero Rojas JGR, Guerrieri G, Guescini F, Gugel R, Guhit JAM, Guida A, Guilloton E, Guindon S, Guo F, Guo J, Guo L, Guo Y, Gupta R, Gupta R, Gurbuz S, Gurdasani SS, Gustavino G, Guth M, Gutierrez P, Gutierrez Zagazeta LF, Gutsche M, Gutschow C, Gwenlan C, Gwilliam CB, Haaland ES, Haas A, Habedank M, Haber C, Hadavand HK, Hadef A, Hadzic S, Hagan AI, Hahn JJ, Haines EH, Haleem M, Haley J, Hall JJ, Hallewell GD, Halser L, Hamano K, Hamer M, Hamity GN, Hampshire EJ, Han J, Han K, Han L, Han L, Han S, Han YF, Hanagaki K, Hance M, Hangal DA, Hanif H, Hank MD, Hankache R, Hansen JB, Hansen JD, Hansen PH, Hara K, Harada D, Harenberg T, Harkusha S, Harris ML, Harris YT, Harrison J, Harrison NM, Harrison PF, Hartman NM, Hartmann NM, Hasegawa Y, Hauser R, Hawkes CM, Hawkings RJ, Hayashi Y, Hayashida S, Hayden D, Hayes C, Hayes RL, Hays CP, Hays JM, Hayward HS, He F, He M, He Y, He Y, Heatley NB, Hedberg V, Heggelund AL, Hehir ND, Heidegger C, Heidegger KK, Heidorn WD, Heilman J, Heim S, Heim T, Heinlein JG, Heinrich JJ, Heinrich L, Hejbal J, Helary L, Held A, Hellesund S, Helling CM, Hellman S, Henderson RCW, Henkelmann L, Henriques Correia AM, Herde H, Hernández Jiménez Y, Herrmann LM, Herrmann T, Herten G, Hertenberger R, Hervas L, Hesping ME, Hessey NP, Hibi H, Hill E, Hillier SJ, Hinds JR, Hinterkeuser F, Hirose M, Hirose S, Hirschbuehl D, Hitchings TG, Hiti B, Hobbs J, Hobincu R, Hod N, Hodgkinson MC, Hodkinson BH, Hoecker A, Hofer DD, Hofer J, Holm T, Holzbock M, Hommels LBAH, Honan BP, Hong J, Hong TM, Hooberman BH, Hopkins WH, Horii Y, Hou S, Howard AS, Howarth J, Hoya J, Hrabovsky M, Hrynevich A, Hryn'ova T, Hsu PJ, Hsu SC, Hu Q, Hu YF, Huang S, Huang X, Huang X, Huang Y, Huang Y, Huang Z, Hubacek Z, Huebner M, Huegging F, Huffman TB, Hugli CA, Huhtinen M, Huiberts SK, Hulsken R, Huseynov N, Huston J, Huth J, Hyneman R, Iacobucci G, Iakovidis G, Ibragimov I, Iconomidou-Fayard L, Iengo P, Iguchi R, Iizawa T, Ikegami Y, Ilic N, Imam H, Ince Lezki M, Ingebretsen Carlson T, Introzzi G, Iodice M, Ippolito V, Irwin RK, Ishino M, Islam W, Issever C, Istin S, Ito H, Iturbe Ponce JM, Iuppa R, Ivina A, Izen JM, Izzo V, Jacka P, Jackson P, Jacobs RM, Jaeger BP, Jagfeld CS, Jain G, Jain P, Jakobs K, Jakoubek T, Jamieson J, Janas KW, Javurkova M, Jeanneau F, Jeanty L, Jejelava J, Jenni P, Jessiman CE, Jézéquel S, Jia C, Jia J, Jia X, Jia X, Jia Z, Jiggins S, Jimenez Pena J, Jin S, Jinaru A, Jinnouchi O, Johansson P, Johns KA, Johnson JW, Jones DM, Jones E, Jones P, Jones RWL, Jones TJ, Joos HL, Joshi R, Jovicevic J, Ju X, Junggeburth JJ, Junkermann T, Juste Rozas A, Juzek MK, Kabana S, Kaczmarska A, Kado M, Kagan H, Kagan M, Kahn A, Kahn A, Kahra C, Kaji T, Kajomovitz E, Kakati N, Kalaitzidou I, Kalderon CW, Kamenshchikov A, Kang NJ, Kar D, Karava K, Kareem MJ, Karentzos E, Karkanias I, Karkout O, Karpov SN, Karpova ZM, Kartvelishvili V, Karyukhin AN, Kasimi E, Katzy J, Kaur S, Kawade K, Kawale MP, Kawamoto C, Kawamoto T, Kay EF, Kaya FI, Kazakos S, Kazanin VF, Ke Y, Keaveney JM, Keeler R, Kehris GV, Keller JS, Kelly AS, Kempster JJ, Kennedy KE, Kennedy PD, Kepka O, Kerridge BP, Kersten S, Kerševan BP, Keshri S, Keszeghova L, Ketabchi Haghighat S, Khan RA, Khandoga M, Khanov A, Kharlamov AG, Kharlamova T, Khoda EE, Kholodenko M, Khoo TJ, Khoriauli G, Khubua J, Khwaira YAR, Kilgallon A, Kim DW, Kim YK, Kimura N, Kingston MK, Kirchhoff A, Kirfel C, Kirfel F, Kirk J, Kiryunin AE, Kitsaki C, Kivernyk O, Klassen M, Klein C, Klein L, Klein MH, Klein M, Klein SB, Klein U, Klimek P, Klimentov A, Klioutchnikova T, Kluit P, Kluth S, Kneringer E, Knight TM, Knue A, Kobayashi R, Kobylianskii D, Koch SF, Kocian M, Kodyš P, Koeck DM, Koenig PT, Koffas T, Kolay O, Koletsou I, Komarek T, Köneke K, Kong AXY, Kono T, Konstantinidis N, Kontaxakis P, Konya B, Kopeliansky R, Koperny S, Korcyl K, Kordas K, Koren G, Korn A, Korn S, Korolkov I, Korotkova N, Kortman B, Kortner O, Kortner S, Kostecka WH, Kostyukhin VV, Kotsokechagia A, Kotwal A, Koulouris A, Kourkoumeli-Charalampidi A, Kourkoumelis C, Kourlitis E, Kovanda O, Kowalewski R, Kozanecki W, Kozhin AS, Kramarenko VA, Kramberger G, Kramer P, Krasny MW, Krasznahorkay A, Kraus JW, Kremer JA, Kresse T, Kretzschmar J, Kreul K, Krieger P, Krishnamurthy S, Krivos M, Krizka K, Kroeninger K, Kroha H, Kroll J, Kroll J, Krowpman KS, Kruchonak U, Krüger H, Krumnack N, Kruse MC, Kuchinskaia O, Kuday S, Kuehn S, Kuesters R, Kuhl T, Kukhtin V, Kulchitsky Y, Kuleshov S, Kumar M, Kumari N, Kumari P, Kupco A, Kupfer T, Kupich A, Kuprash O, Kurashige H, Kurchaninov LL, Kurdysh O, Kurochkin YA, Kurova A, Kuze M, Kvam AK, Kvita J, Kwan T, Kyriacou NG, Laatu LAO, Lacasta C, Lacava F, Lacker H, Lacour D, Lad NN, Ladygin E, Laforge B, Lagouri T, Lahbabi FZ, Lai S, Lakomiec IK, Lalloue N, Lambert JE, Lammers S, Lampl W, Lampoudis C, Lancaster AN, Lançon E, Landgraf U, Landon MPJ, Lang VS, Langenberg RJ, Langrekken OKB, Lankford AJ, Lanni F, Lantzsch K, Lanza A, Lapertosa A, Laporte JF, Lari T, Lasagni Manghi F, Lassnig M, Latonova V, Laudrain A, Laurier A, Lawlor SD, Lawrence Z, Lazaridou R, Lazzaroni M, Le B, Le Boulicaut EM, Leban B, Lebedev A, LeBlanc M, Ledroit-Guillon F, Lee ACA, Lee SC, Lee S, Lee TF, Leeuw LL, Lefebvre HP, Lefebvre M, Leggett C, Lehmann Miotto G, Leigh M, Leight WA, Leinonen W, Leisos A, Leite MAL, Leitgeb CE, Leitner R, Leney KJC, Lenz T, Leone S, Leonidopoulos C, Leopold A, Leroy C, Les R, Lester CG, Levchenko M, Levêque J, Levin D, Levinson LJ, Lewicki MP, Lewis DJ, Li A, Li B, Li C, Li CQ, Li H, Li H, Li H, Li H, Li H, Li J, Li K, Li L, Li M, Li QY, Li S, Li S, Li T, Li X, Li Z, Li Z, Li Z, Liang S, Liang Z, Liberatore M, Liberti B, Lie K, Lieber Marin J, Lien H, Lin K, Lindley RE, Lindon JH, Lipeles E, Lipniacka A, Lister A, Little JD, Liu B, Liu BX, Liu D, Liu JB, Liu JKK, Liu K, Liu M, Liu MY, Liu P, Liu Q, Liu X, Liu X, Liu Y, Liu YL, Liu YW, Llorente Merino J, Lloyd SL, Lobodzinska EM, Loch P, Lohse T, Lohwasser K, Loiacono E, Lokajicek M, Lomas JD, Long JD, Longarini I, Longo L, Longo R, Lopez Paz I, Lopez Solis A, Lorenz J, Lorenzo Martinez N, Lory AM, Löschcke Centeno G, Loseva O, Lou X, Lou X, Lounis A, Love J, Love PA, Lu G, Lu M, Lu S, Lu YJ, Lubatti HJ, Luci C, Lucio Alves FL, Lucotte A, Luehring F, Luise I, Lukianchuk O, Lundberg O, Lund-Jensen B, Luongo NA, Lutz MS, Lux AB, Lynn D, Lyons H, Lysak R, Lytken E, Lyubushkin V, Lyubushkina T, Lyukova MM, Ma H, Ma K, Ma LL, Ma W, Ma Y, Mac Donell DM, Maccarrone G, MacDonald JC, Machado De Abreu Farias PC, Madar R, Mader WF, Madula T, Maeda J, Maeno T, Maguire H, Maiboroda V, Maio A, Maj K, Majersky O, Majewski S, Makovec N, Maksimovic V, Malaescu B, Malecki P, Maleev VP, Malek F, Mali M, Malito D, Mallik U, Maltezos S, Malyukov S, Mamuzic J, Mancini G, Manco G, Mandalia JP, Mandić I, Manhaes de Andrade Filho L, Maniatis IM, Manjarres Ramos J, Mankad DC, Mann A, Mansoulie B, Manzoni S, Mao L, Mapekula X, Marantis A, Marchiori G, Marcisovsky M, Marcon C, Marinescu M, Marium S, Marjanovic M, Marshall EJ, Marshall Z, Marti-Garcia S, Martin TA, Martin VJ, Martin Dit Latour B, Martinelli L, Martinez M, Martinez Agullo P, Martinez Outschoorn VI, Martinez Suarez P, Martin-Haugh S, Martoiu VS, Martyniuk AC, Marzin A, Mascione D, Masetti L, Mashimo T, Masik J, Maslennikov AL, Massa L, Massarotti P, Mastrandrea P, Mastroberardino A, Masubuchi T, Mathisen T, Matousek J, Matsuzawa N, Maurer J, Maček B, Maximov DA, Mazini R, Maznas I, Mazza M, Mazza SM, Mazzeo E, Mc Ginn C, Mc Gowan JP, Mc Kee SP, McCracken CC, McDonald EF, McDougall AE, Mcfayden JA, McGovern RP, Mchedlidze G, Mckenzie RP, Mclachlan TC, Mclaughlin DJ, McMahon SJ, Mcpartland CM, McPherson RA, Mehlhase S, Mehta A, Melini D, Mellado Garcia BR, Melo AH, Meloni F, Mendes Jacques Da Costa AM, Meng HY, Meng L, Menke S, Mentink M, Meoni E, Mercado G, Merlassino C, Merola L, Meroni C, Merz G, Metcalfe J, Mete AS, Meyer C, Meyer JP, Middleton RP, Mijović L, Mikenberg G, Mikestikova M, Mikuž M, Mildner H, Milic A, Milke CD, Miller DW, Miller LS, Milov A, Milstead DA, Min T, Minaenko AA, Minashvili IA, Mince L, Mincer AI, Mindur B, Mineev M, Mino Y, Mir LM, Miralles Lopez M, Mironova M, Mishima A, Missio MC, Mitra A, Mitsou VA, Mitsumori Y, Miu O, Miyagawa PS, Mkrtchyan T, Mlinarevic M, Mlinarevic T, Mlynarikova M, Mobius S, Moder P, Mogg P, Mohamed Farook MH, Mohammed AF, Mohapatra S, Mokgatitswane G, Moleri L, Mondal B, Mondal S, Mönig K, Monnier E, Monsonis Romero L, Montejo Berlingen J, Montella M, Montereali F, Monticelli F, Monzani S, Morange N, De Carvalho ALM, Moreno Llácer M, Moreno Martinez C, Morettini P, Morgenstern S, Morii M, Morinaga M, Morley AK, Morodei F, Morvaj L, Moschovakos P, Moser B, Mosidze M, Moskalets T, Moskvitina P, Moss J, Moyse EJW, Mtintsilana O, Muanza S, Mueller J, Muenstermann D, Müller R, Mullier GA, Mullin AJ, Mullin JJ, Mungo DP, Munoz Perez D, Munoz Sanchez FJ, Murin M, Murray WJ, Murrone A, Muškinja M, Mwewa C, Myagkov AG, Myers AJ, Myers G, Myska M, Nachman BP, Nackenhorst O, Nag A, Nagai K, Nagano K, Nagle JL, Nagy E, Nairz AM, Nakahama Y, Nakamura K, Nakkalil K, Nanjo H, Narayan R, Narayanan EA, Naryshkin I, Naseri M, Nasri S, Nass C, Navarro G, Navarro-Gonzalez J, Nayak R, Nayaz A, Nechaeva PY, Nechansky F, Nedic L, Neep TJ, Negri A, Negrini M, Nellist C, Nelson C, Nelson K, Nemecek S, Nessi M, Neubauer MS, Neuhaus F, Neundorf J, Newhouse R, Newman PR, Ng CW, Ng YWY, Ngair B, Nguyen HDN, Nickerson RB, Nicolaidou R, Nielsen J, Niemeyer M, Niermann J, Nikiforou N, Nikolaenko V, Nikolic-Audit I, Nikolopoulos K, Nilsson P, Ninca I, Nindhito HR, Ninio G, Nisati A, Nishu N, Nisius R, Nitschke JE, Nkadimeng EK, Nobe T, Noel DL, Nommensen T, Norfolk MB, Norisam RRB, Norman BJ, Noury M, Novak J, Novak T, Novotny L, Novotny R, Nozka L, Ntekas K, Nunes De Moura Junior NMJ, Nurse E, Ocariz J, Ochi A, Ochoa I, Oerdek S, Offermann JT, Ogrodnik A, Oh A, Ohm CC, Oide H, Oishi R, Ojeda ML, O'Keefe MW, Okumura Y, Seabra LFO, Olivares Pino SA, Oliveira Damazio D, Oliveira Goncalves D, Oliver JL, Öncel ÖO, O'Neill AP, Onofre A, Onyisi PUE, Oreglia MJ, Orellana GE, Orestano D, Orlando N, Orr RS, O'Shea V, Osojnak LM, Ospanov R, Otero Y Garzon G, Otono H, Ott PS, Ottino GJ, Ouchrif M, Ouellette J, Ould-Saada F, Owen M, Owen RE, Oyulmaz KY, Ozcan VE, Ozturk F, Ozturk N, Ozturk S, Pacey HA, Pacheco Pages A, Padilla Aranda C, Padovano G, Pagan Griso S, Palacino G, Palazzo A, Palestini S, Pan J, Pan T, Panchal DK, Pandini CE, Panduro Vazquez JG, Pandya HD, Pang H, Pani P, Panizzo G, Paolozzi L, Papadatos C, Parajuli S, Paramonov A, Paraskevopoulos C, Paredes Hernandez D, Park KR, Park TH, Parker MA, Parodi F, Parrish EW, Parrish VA, Parsons JA, Parzefall U, Pascual Dias B, Pascual Dominguez L, Pasqualucci E, Passaggio S, Pastore F, Pasuwan P, Patel P, Patel UM, Pater JR, Pauly T, Pearkes J, Pedersen M, Pedro R, Peleganchuk SV, Penc O, Pender EA, Penski KE, Penzin M, Peralva BS, Peixoto APP, Pereira Sanchez L, Perepelitsa DV, Perez Codina E, Perganti M, Perini L, Pernegger H, Perrin O, Peters K, Peters RFY, Petersen BA, Petersen TC, Petit E, Petousis V, Petridou C, Petrukhin A, Pettee M, Pettersson NE, Petukhov A, Petukhova K, Pezoa R, Pezzotti L, Pezzullo G, Pham TM, Pham T, Phillips PW, Piacquadio G, Pianori E, Piazza F, Piegaia R, Pietreanu D, Pilkington AD, Pinamonti M, Pinfold JL, Pereira BCP, Pinto Pinoargote AE, Pintucci L, Piper KM, Pirttikoski A, Pizzi DA, Pizzimento L, Pizzini A, Pleier MA, Plesanovs V, Pleskot V, Plotnikova E, Poddar G, Poettgen R, Poggioli L, Pokharel I, Polacek S, Polesello G, Poley A, Polifka R, Polini A, Pollard CS, Pollock ZB, Polychronakos V, Pompa Pacchi E, Ponomarenko D, Pontecorvo L, Popa S, Popeneciu GA, Poreba A, Portillo Quintero DM, Pospisil S, Postill MA, Postolache P, Potamianos K, Potepa PA, Potrap IN, Potter CJ, Potti H, Poulsen T, Poveda J, Pozo Astigarraga ME, Prades Ibanez A, Pretel J, Price D, Primavera M, Principe Martin MA, Privara R, Procter T, Proffitt ML, Proklova N, Prokofiev K, Proto G, Protopopescu S, Proudfoot J, Przybycien M, Przygoda WW, Puddefoot JE, Pudzha D, Pyatiizbyantseva D, Qian J, Qichen D, Qin Y, Qiu T, Quadt A, Queitsch-Maitland M, Quetant G, Quinn RP, Rabanal Bolanos G, Rafanoharana D, Ragusa F, Rainbolt JL, Raine JA, Rajagopalan S, Ramakoti E, Ramirez-Berend IA, Ran K, Rapheeha NP, Rasheed H, Raskina V, Rassloff DF, Rastogi A, Rave S, Ravina B, Ravinovich I, Raymond M, Read AL, Readioff NP, Rebuzzi DM, Redlinger G, Reed AS, Reeves K, Reidelsturz JA, Reikher D, Rej A, Rembser C, Renardi A, Renda M, Rendel MB, Renner F, Rennie AG, Rescia AL, Resconi S, Ressegotti M, Rettie S, Reyes Rivera JG, Reynolds E, Rezanova OL, Reznicek P, Ribaric N, Ricci E, Richter R, Richter S, Richter-Was E, Ridel M, Ridouani S, Rieck P, Riedler P, Riefel EM, Rieger JO, Rijssenbeek M, Rimoldi A, Rimoldi M, Rinaldi L, Rinn TT, Rinnagel MP, Ripellino G, Riu I, Rivadeneira P, Rivera Vergara JC, Rizatdinova F, Rizvi E, Roberts BA, Roberts BR, Robertson SH, Robinson D, Robles Gajardo CM, Robles Manzano M, Robson A, Rocchi A, Roda C, Rodriguez Bosca S, Rodriguez Garcia Y, Rodriguez Rodriguez A, Rodríguez Vera AM, Roe S, Roemer JT, Roepe-Gier AR, Roggel J, Røhne O, Rojas RA, Roland CPA, Roloff J, Romaniouk A, Romano E, Romano M, Romero Hernandez AC, Rompotis N, Roos L, Rosati S, Rosser BJ, Rossi E, Rossi E, Rossi LP, Rossini L, Rosten R, Rotaru M, Rottler B, Rougier C, Rousseau D, Rousso D, Roy A, Roy-Garand S, Rozanov A, Rozario ZMA, Rozen Y, Ruan X, Rubio Jimenez A, Ruby AJ, Ruelas Rivera VH, Ruggeri TA, Ruggiero A, Ruiz-Martinez A, Rummler A, Rurikova Z, Rusakovich NA, Russell HL, Russo G, Rutherfoord JP, Rutherford Colmenares S, Rybacki K, Rybar M, Rye EB, Ryzhov A, Sabater Iglesias JA, Sabatini P, Sadrozinski HF, Safai Tehrani F, Safarzadeh Samani B, Safdari M, Saha S, Sahinsoy M, Saibel A, Saimpert M, Saito M, Saito T, Salamani D, Salnikov A, Salt J, Salvador Salas A, Salvatore D, Salvatore F, Salzburger A, Sammel D, Sampsonidis D, Sampsonidou D, Sánchez J, Sanchez Pineda A, Sanchez Sebastian V, Sandaker H, Sander CO, Sandesara JA, Sandhoff M, Sandoval C, Sankey DPC, Sano T, Sansoni A, Santi L, Santoni C, Santos H, Santpur SN, Santra A, Saoucha KA, Saraiva JG, Sardain J, Sasaki O, Sato K, Sauer C, Sauerburger F, Sauvan E, Savard P, Sawada R, Sawyer C, Sawyer L, Sayago Galvan I, Sbarra C, Sbrizzi A, Scanlon T, Schaarschmidt J, Schacht P, Schäfer U, Schaffer AC, Schaile D, Schamberger RD, Scharf C, Schefer MM, Schegelsky VA, Scheirich D, Schenck F, Schernau M, Scheulen C, Schiavi C, Schioppa EJ, Schioppa M, Schlag B, Schleicher KE, Schlenker S, Schmeing J, Schmidt MA, Schmieden K, Schmitt C, Schmitt N, Schmitt S, Schoeffel L, Schoening A, Scholer PG, Schopf E, Schott M, Schovancova J, Schramm S, Schroeder F, Schroer T, Schultz-Coulon HC, Schumacher M, Schumm BA, Schune P, Schuy AJ, Schwartz HR, Schwartzman A, Schwarz TA, Schwemling P, Schwienhorst R, Sciandra A, Sciolla G, Scuri F, Sebastiani CD, Sedlaczek K, Seema P, Seidel SC, Seiden A, Seidlitz BD, Seitz C, Seixas JM, Sekhniaidze G, Sekula SJ, Selem L, Semprini-Cesari N, Sengupta D, Senthilkumar V, Serin L, Serkin L, Sessa M, Severini H, Sforza F, Sfyrla A, Shabalina E, Shaheen R, Shahinian JD, Shaked Renous D, Shan LY, Shapiro M, Sharma A, Sharma AS, Sharma P, Sharma S, Shatalov PB, Shaw K, Shaw SM, Shcherbakova A, Shen Q, Sheppard DJ, Sherwood P, Shi L, Shi X, Shimmin CO, Shinner JD, Shipsey IPJ, Shirabe S, Shiyakova M, Shlomi J, Shochet MJ, Shojaii J, Shope DR, Shrestha B, Shrestha S, Shrif EM, Shroff MJ, Sicho P, Sickles AM, Sideras Haddad E, Sidoti A, Siegert F, Sijacki D, Sili F, Silva JM, Silva Oliveira MV, Silverstein SB, Simion S, Simoniello R, Simpson EL, Simpson H, Simpson LR, Simpson ND, Simsek S, Sindhu S, Sinervo P, Singh S, Sinha S, Sinha S, Sioli M, Siral I, Sitnikova E, Sivoklokov SY, Sjölin J, Skaf A, Skorda E, Skubic P, Slawinska M, Smakhtin V, Smart BH, Smiesko J, Smirnov SY, Smirnov Y, Smirnova LN, Smirnova O, Smith AC, Smith EA, Smith HA, Smith JL, Smith R, Smizanska M, Smolek K, Snesarev AA, Snider SR, Snoek HL, Snyder S, Sobie R, Soffer A, Solans Sanchez CA, Soldatov EY, Soldevila U, Solodkov AA, Solomon S, Soloshenko A, Solovieva K, Solovyanov OV, Solovyev V, Sommer P, Sonay A, Song WY, Sonneveld JM, Sopczak A, Sopio AL, Sopkova F, Sotarriva Alvarez IR, Sothilingam V, Soto Sandoval OJ, Sottocornola S, Soualah R, Soumaimi Z, South D, Soybelman N, Spagnolo S, Spalla M, Sperlich D, Spigo G, Spinali S, Spiteri DP, Spousta M, Staats EJ, Stabile A, Stamen R, Stampekis A, Standke M, Stanecka E, Stange MV, Stanislaus B, Stanitzki MM, Stapf B, Starchenko EA, Stark GH, Stark J, Starko DM, Staroba P, Starovoitov P, Stärz S, Staszewski R, Stavropoulos G, Steentoft J, Steinberg P, Stelzer B, Stelzer HJ, Stelzer-Chilton O, Stenzel H, Stevenson TJ, Stewart GA, Stewart JR, Stockton MC, Stoicea G, Stolarski M, Stonjek S, Straessner A, Strandberg J, Strandberg S, Stratmann M, Strauss M, Strebler T, Strizenec P, Ströhmer R, Strom DM, Stroynowski R, Strubig A, Stucci SA, Stugu B, Stupak J, Styles NA, Su D, Su S, Su W, Su X, Sugizaki K, Sulin VV, Sullivan MJ, Sultan DMS, Sultanaliyeva L, Sultansoy S, Sumida T, Sun S, Sun S, Gudnadottir OS, Sur N, Sutton MR, Suzuki H, Svatos M, Swiatlowski M, Swirski T, Sykora I, Sykora M, Sykora T, Ta D, Tackmann K, Taffard A, Tafirout R, Tafoya Vargas JS, Takeva EP, Takubo Y, Talby M, Talyshev AA, Tam KC, Tamir NM, Tanaka A, Tanaka J, Tanaka R, Tanasini M, Tao Z, Tapia Araya S, Tapprogge S, Tarek Abouelfadl Mohamed A, Tarem S, Tariq K, Tarna G, Tartarelli GF, Tas P, Tasevsky M, Tassi E, Tate AC, Tateno G, Tayalati Y, Taylor GN, Taylor W, Tee AS, Teixeira De Lima R, Teixeira-Dias P, Teoh JJ, Terashi K, Terron J, Terzo S, Testa M, Teuscher RJ, Thaler A, Theiner O, Themistokleous N, Theveneaux-Pelzer T, Thielmann O, Thomas DW, Thomas JP, Thompson EA, Thompson PD, Thomson E, Tian Y, Tikhomirov V, Tikhonov YA, Timoshenko S, Timoshyn D, Ting EXL, Tipton P, Tlou SH, Tnourji A, Todome K, Todorova-Nova S, Todt S, Togawa M, Tojo J, Tokár S, Tokushuku K, Toldaiev O, Tombs R, Tomoto M, Tompkins L, Topolnicki KW, Torrence E, Torres H, Torró Pastor E, Toscani M, Tosciri C, Tost M, Tovey DR, Traeet A, Trandafir IS, Trefzger T, Tricoli A, Trigger IM, Trincaz-Duvoid S, Trischuk DA, Trocmé B, Troncon C, Truong L, Trzebinski M, Trzupek A, Tsai F, Tsai M, Tsiamis A, Tsiareshka PV, Tsigaridas S, Tsirigotis A, Tsiskaridze V, Tskhadadze EG, Tsopoulou M, Tsujikawa Y, Tsukerman II, Tsulaia V, Tsuno S, Tsuri K, Tsybychev D, Tu Y, Tudorache A, Tudorache V, Tuna AN, Turchikhin S, Turk Cakir I, Turra R, Turtuvshin T, Tuts PM, Tzamarias S, Tzanis P, Tzovara E, Ukegawa F, Ulloa Poblete PA, Umaka EN, Unal G, Unal M, Undrus A, Unel G, Urban J, Urquijo P, Urrejola P, Usai G, Ushioda R, Usman M, Uysal Z, Vacek V, Vachon B, Vadla KOH, Vafeiadis T, Vaitkus A, Valderanis C, Valdes Santurio E, Valente M, Valentinetti S, Valero A, Valiente Moreno E, Vallier A, Valls Ferrer JA, Van Arneman DR, Van Daalen TR, Van Der Graaf A, Van Gemmeren P, Van Rijnbach M, Van Stroud S, Van Vulpen I, Vanadia M, Vandelli W, Vandenbroucke M, Vandewall ER, Vannicola D, Vannoli L, Vari R, Varnes EW, Varni C, Varol T, Varouchas D, Varriale L, Varvell KE, Vasile ME, Vaslin L, Vasquez GA, Vasyukov A, Vazeille F, Vazquez Schroeder T, Veatch J, Vecchio V, Veen MJ, Veliscek I, Veloce LM, Veloso F, Veneziano S, Ventura A, Ventura Gonzalez S, Verbytskyi A, Verducci M, Vergis C, Verissimo De Araujo M, Verkerke W, Vermeulen JC, Vernieri C, Vessella M, Vetterli MC, Vgenopoulos A, Viaux Maira N, Vickey T, Vickey Boeriu OE, Viehhauser GHA, Vigani L, Villa M, Villaplana Perez M, Villhauer EM, Vilucchi E, Vincter MG, Virdee GS, Vishwakarma A, Visibile A, Vittori C, Vivarelli I, Voevodina E, Vogel F, Voigt JC, Vokac P, Volkotrub Y, Von Ahnen J, Von Toerne E, Vormwald B, Vorobel V, Vorobev K, Vos M, Voss K, Vossebeld JH, Vozak M, Vozdecky L, Vranjes N, Vranjes Milosavljevic M, Vreeswijk M, Vuillermet R, Vujinovic O, Vukotic I, Wada S, Wagner C, Wagner JM, Wagner W, Wahdan S, Wahlberg H, Wakida M, Walder J, Walker R, Walkowiak W, Wall A, Wamorkar T, Wang AZ, Wang C, Wang C, Wang H, Wang J, Wang RJ, Wang R, Wang R, Wang SM, Wang S, Wang T, Wang WT, Wang W, Wang X, Wang X, Wang X, Wang Y, Wang Y, Wang Z, Wang Z, Wang Z, Warburton A, Ward RJ, Warrack N, Watson AT, Watson H, Watson MF, Watton E, Watts G, Waugh BM, Weber C, Weber HA, Weber MS, Weber SM, Wei C, Wei Y, Weidberg AR, Weik EJ, Weingarten J, Weirich M, Weiser C, Wells CJ, Wenaus T, Wendland B, Wengler T, Wenke NS, Wermes N, Wessels M, Wharton AM, White AS, White A, White MJ, Whiteson D, Wickremasinghe L, Wiedenmann W, Wiel C, Wielers M, Wiglesworth C, Wilbern DJ, Wilkens HG, Williams DM, Williams HH, Williams S, Willocq S, Wilson BJ, Windischhofer PJ, Winkel FI, Winklmeier F, Winter BT, Winter JK, Wittgen M, Wobisch M, Wolffs Z, Wollrath J, Wolter MW, Wolters H, Wongel AF, Woodward EL, Worm SD, Wosiek BK, Woźniak KW, Wozniewski S, Wraight K, Wu C, Wu J, Wu M, Wu M, Wu SL, Wu X, Wu Y, Wu Z, Wuerzinger J, Wyatt TR, Wynne BM, Xella S, Xia L, Xia M, Xiang J, Xie M, Xie X, Xin S, Xiong A, Xiong J, Xu D, Xu H, Xu L, Xu R, Xu T, Xu Y, Xu Z, Xu Z, Yabsley B, Yacoob S, Yamaguchi Y, Yamashita E, Yamauchi H, Yamazaki T, Yamazaki Y, Yan J, Yan S, Yan Z, Yang HJ, Yang HT, Yang S, Yang T, Yang X, Yang X, Yang Y, Yang Y, Yang Z, Yao WM, Yap YC, Ye H, Ye H, Ye J, Ye S, Ye X, Yeh Y, Yeletskikh I, Yeo BK, Yexley MR, Yin P, Yorita K, Younas S, Young CJS, Young C, Yu C, Yu Y, Yuan M, Yuan R, Yue L, Zaazoua M, Zabinski B, Zaid E, Zak ZK, Zakareishvili T, Zakharchuk N, Zambito S, Zamora Saa JA, Zang J, Zanzi D, Zaplatilek O, Zeitnitz C, Zeng H, Zeng JC, Zenger DT, Zenin O, Ženiš T, Zenz S, Zerradi S, Zerwas D, Zhai M, Zhang B, Zhang DF, Zhang J, Zhang J, Zhang K, Zhang L, Zhang P, Zhang R, Zhang S, Zhang S, Zhang T, Zhang X, Zhang X, Zhang Y, Zhang Y, Zhang Y, Zhang Z, Zhang Z, Zhao H, Zhao T, Zhao Y, Zhao Z, Zhemchugov A, Zheng J, Zheng K, Zheng X, Zheng Z, Zhong D, Zhou B, Zhou H, Zhou N, Zhou Y, Zhu CG, Zhu J, Zhu Y, Zhu Y, Zhuang X, Zhukov K, Zhulanov V, Zimine NI, Zinsser J, Ziolkowski M, Živković L, Zoccoli A, Zoch K, Zorbas TG, Zormpa O, Zou W, and Zwalinski L

Abstract

Statistical combinations of searches for charginos and neutralinos using various decay channels are performed using 139  fb^{-1} of pp collision data at sqrt[s]=13  TeV with the ATLAS detector at the Large Hadron Collider. Searches targeting pure-wino chargino pair production, pure-wino chargino-neutralino production, or Higgsino production decaying via standard model W, Z, or h bosons are combined to extend the mass reach to the produced supersymmetric particles by 30-100 GeV. The depth of the sensitivity of the original searches is also improved by the combinations, lowering the 95% C.L. cross-section upper limits by 15%-40%.

Published
2024
Full Text
View/download PDF

99. Improved diet-based nutritional interventions can improve childhood obesity with the synergistic regulation of gut microbiota.

Author

Zhou M, Peng C, Miao Z, Wang K, Zhou H, Li Y, Xiao G, and Wu X

Subjects
Humans, Child, Male, Female, RNA, Ribosomal, 16S genetics, Fatty Acids, Volatile metabolism, Fatty Acids, Volatile analysis, Bacteria classification, Bacteria genetics, Bacteria isolation & purification, Body Mass Index, Body Composition, Diet, Body Weight, Gastrointestinal Microbiome, Pediatric Obesity diet therapy, Pediatric Obesity microbiology, Feces microbiology
Abstract

Childhood obesity is a crucial public health concern worldwide. Dietary intervention is the most common intervention for the treatment of obesity. Therefore, we tested an improved diet-based nutritional interventions to improve the childhood obesity and its gut microbiota. Thirty obese children received a 12-week intervention with the adjust-energy-restricted dietary pattern (A-CRD). Body composition was measured by bioelectrical impedance (Inbody S10) and faecal microbes were profiled by sequencing 16S rRNA. Compared to the NTB group (at 0 week), the NTA group (at 12 weeks) had a significantly greater decrease in body weight, body mass index (BMI) and percent body fat (PBF) ( P < 0.001, respectively), whereas skeletal muscle mass (SMM) and fat free mass (FFM) were not statistically significantly different ( P > 0.05). The gut microbiota was found significantly different between the NTB and NTA groups based on alpha and beta diversity. Bifidobacterium, Blautia, and Streptococcus was significantly increased, whereas Bacteroides and Megamonas was significantly decreased in the NTA group ( P < 0.05, respectively). Meanwhile, NTA group significantly increased the ability to produce short-chain fatty acids (SCFAs; e.g. acetic acid/total dietary energy) and changed he predictive metabolic functional features of the microbiota communities ( P < 0.05, respectively) than the NTB group. In conclusion, A-CRD can significantly improve childhood obesity, and the underlying mechanism may be its effect on gut microbiota and metabolism. Therefore, the diet-based nutrition intervention targeting gut microbiota will be more effective management of body weight and prevention of obesity. Chinese Clinical Trial Register: ChiCTR2300074571.

Published
2024
Full Text
View/download PDF

100. Measurements of Normalized Differential Cross Sections of Inclusive η Production in e^{+}e^{-} Annihilation at Energy from 2.0000 to 3.6710 GeV.

Author

Ablikim M, Achasov MN, Adlarson P, Afedulidis O, Ai XC, Aliberti R, Amoroso A, An Q, Anderle D, Bai Y, Bakina O, Balossino I, Ban Y, Bao HR, Batozskaya V, Begzsuren K, Berger N, Berlowski M, Bertani M, Bettoni D, Bianchi F, Bianco E, Bortone A, Boyko I, Briere RA, Brueggemann A, Cai H, Cai X, Calcaterra A, Cao GF, Cao N, Cetin SA, Chang JF, Che GR, Chelkov G, Chen C, Chen CH, Chen C, Chen G, Chen HS, Chen HY, Chen ML, Chen SJ, Chen SL, Chen SM, Chen T, Chen XR, Chen XT, Chen YB, Chen YQ, Chen ZJ, Chen ZY, Choi SK, Cibinetto G, Cossio F, Cui JJ, Dai HL, Dai JP, Dbeyssi A, de Boer RE, Dedovich D, Deng CQ, Deng ZY, Denig A, Denysenko I, Destefanis M, De Mori F, Ding B, Ding XX, Ding Y, Ding Y, Dong J, Dong LY, Dong MY, Dong X, Du MC, Du SX, Duan YY, Duan ZH, Egorov P, Fan YH, Fang J, Fang J, Fang SS, Fang WX, Fang Y, Fang YQ, Farinelli R, Fava L, Feldbauer F, Felici G, Feng CQ, Feng JH, Feng YT, Fritsch M, Fu CD, Fu JL, Fu YW, Gao H, Gao XB, Gao YN, Gao Y, Garbolino S, Garzia I, Ge L, Ge PT, Ge ZW, Geng C, Gersabeck EM, Gilman A, Goetzen K, Gong L, Gong WX, Gradl W, Gramigna S, Greco M, Gu MH, Gu YT, Guan CY, Guan ZL, Guo AQ, Guo LB, Guo MJ, Guo RP, Guo YP, Guskov A, Gutierrez J, Han KL, Han TT, Hanisch F, Hao XQ, Harris FA, He KK, He KL, Heinsius FH, Heinz CH, Heng YK, Herold C, Holtmann T, Hong PC, Hou GY, Hou XT, Hou YR, Hou ZL, Hu BY, Hu HM, Hu JF, Hu SL, Hu T, Hu Y, Huang GS, Huang KX, Huang LQ, Huang XT, Huang YP, Hussain T, Hölzken F, Hüsken N, Hüsken N, In der Wiesche N, Jackson J, Janchiv S, Jeong JH, Ji Q, Ji QP, Ji W, Ji XB, Ji XL, Ji YY, Jia XQ, Jia ZK, Jiang D, Jiang HB, Jiang PC, Jiang SS, Jiang TJ, Jiang XS, Jiang Y, Jiao JB, Jiao JK, Jiao Z, Jin S, Jin Y, Jing MQ, Jing XM, Johansson T, Kabana S, Kalantar-Nayestanaki N, Kang XL, Kang XS, Kavatsyuk M, Ke BC, Khachatryan V, Khoukaz A, Kiuchi R, Kolcu OB, Kopf B, Kuessner M, Kui X, Kumar N, Kupsc A, Kühn W, Lane JJ, Larin P, Lavezzi L, Lei TT, Lei ZH, Lellmann M, Lenz T, Li C, Li C, Li CH, Li C, Li DM, Li F, Li G, Li HB, Li HJ, Li HN, Li H, Li JR, Li JS, Li K, Li LJ, Li LK, Li L, Li MH, Li MY, Li PR, Li QM, Li QX, Li R, Li SX, Li T, Li WD, Li WG, Li X, Li XH, Li XL, Li XZ, Li X, Li YG, Li ZJ, Li ZX, Li ZY, Liang C, Liang H, Liang H, Liang YF, Liang YT, Liao GR, Liao LZ, Libby J, Limphirat A, Lin CC, Lin DX, Lin T, Liu BJ, Liu BX, Liu C, Liu CX, Liu FH, Liu F, Liu F, Liu GM, Liu H, Liu HB, Liu HM, Liu H, Liu H, Liu JB, Liu JY, Liu K, Liu KY, Liu K, Liu L, Liu LC, Liu L, Liu MH, Liu PL, Liu Q, Liu SB, Liu T, Liu WK, Liu WM, Liu X, Liu X, Liu Y, Liu Y, Liu YB, Liu ZA, Liu ZD, Liu ZQ, Lou XC, Lu FX, Lu HJ, Lu JG, Lu XL, Lu Y, Lu YP, Lu ZH, Luo CL, Luo MX, Luo T, Luo XL, Lyu XR, Lyu YF, Ma FC, Ma H, Ma HL, Ma JL, Ma LL, Ma MM, Ma QM, Ma RQ, Ma T, Ma XT, Ma XY, Ma Y, Ma YM, Maas FE, Maggiora M, Malde S, Mao YJ, Mao ZP, Marcello S, Meng ZX, Messchendorp JG, Mezzadri G, Miao H, Min TJ, Mitchell RE, Mo XH, Moses B, Muchnoi NY, Muskalla J, Nefedov Y, Nerling F, Nie LS, Nikolaev IB, Ning Z, Nisar S, Niu QL, Niu WD, Niu Y, Olsen SL, Ouyang Q, Pacetti S, Pan X, Pan Y, Pathak A, Patteri P, Pei YP, Pelizaeus M, Peng HP, Peng YY, Peters K, Ping JL, Ping RG, Plura S, Prasad V, Qi FZ, Qi H, Qi HR, Qi M, Qi TY, Qian S, Qian WB, Qiao CF, Qiao XK, Qin JJ, Qin LQ, Qin LY, Qin XS, Qin ZH, Qiu JF, Qu ZH, Redmer CF, Ren KJ, Rivetti A, Rolo M, Rong G, Rosner C, Ruan SN, Salone N, Sarantsev A, Schelhaas Y, Schoenning K, Scodeggio M, Shan KY, Shan W, Shan XY, Shang ZJ, Shangguan JF, Shao LG, Shao M, Shen CP, Shen HF, Shen WH, Shen XY, Shi BA, Shi H, Shi HC, Shi JL, Shi JY, Shi QQ, Shi SY, Shi X, Song JJ, Song TZ, Song WM, Song YJ, Song YX, Sosio S, Spataro S, Stieler F, Su YJ, Sun GB, Sun GX, Sun H, Sun HK, Sun JF, Sun K, Sun L, Sun SS, Sun T, Sun WY, Sun Y, Sun YJ, Sun YZ, Sun ZQ, Sun ZT, Tang CJ, Tang GY, Tang J, Tang M, Tang YA, Tao LY, Tao QT, Tat M, Teng JX, Thoren V, Tian WH, Tian Y, Tian ZF, Uman I, Wan Y, Wang SJ, Wang B, Wang BL, Wang B, Wang DY, Wang F, Wang HJ, Wang JJ, Wang JP, Wang K, Wang LL, Wang M, Wang M, Wang NY, Wang S, Wang S, Wang T, Wang TJ, Wang W, Wang W, Wang WP, Wang X, Wang XF, Wang XJ, Wang XL, Wang XN, Wang Y, Wang YD, Wang YF, Wang YL, Wang YN, Wang YQ, Wang Y, Wang Y, Wang Z, Wang ZL, Wang ZY, Wang Z, Wei DH, Weidner F, Wen SP, Wen YR, Wiedner U, Wilkinson G, Wolke M, Wollenberg L, Wu C, Wu JF, Wu LH, Wu LJ, Wu X, Wu XH, Wu Y, Wu YH, Wu YJ, Wu Z, Xia L, Xian XM, Xiang BH, Xiang T, Xiao D, Xiao GY, Xiao SY, Xiao YL, Xiao ZJ, Xie C, Xie XH, Xie Y, Xie YG, Xie YH, Xie ZP, Xing HX, Xing TY, Xu CF, Xu CJ, Xu GF, Xu HY, Xu M, Xu QJ, Xu QN, Xu W, Xu WL, Xu XP, Xu YC, Xu ZP, Xu ZS, Yan F, Yan L, Yan WB, Yan WC, Yan XQ, Yang HJ, Yang HL, Yang HX, Yang T, Yang Y, Yang YF, Yang YX, Yang Y, Yang ZW, Yao ZP, Ye M, Ye MH, Yin JH, You ZY, Yu BX, Yu CX, Yu G, Yu JS, Yu T, Yu XD, Yu YC, Yuan CZ, Yuan J, Yuan L, Yuan SC, Yuan Y, Yuan YJ, Yuan ZY, Yue CX, Zafar AA, Zeng FR, Zeng SH, Zeng X, Zeng Y, Zeng YJ, Zhai XY, Zhai YC, Zhan YH, Zhang AQ, Zhang BL, Zhang BX, Zhang DH, Zhang GY, Zhang H, Zhang H, Zhang HC, Zhang HH, Zhang HH, Zhang HQ, Zhang HR, Zhang HY, Zhang J, Zhang J, Zhang JJ, Zhang JL, Zhang JQ, Zhang JS, Zhang JW, Zhang JX, Zhang JY, Zhang JZ, Zhang J, Zhang LM, Zhang L, Zhang P, Zhang QY, Zhang RY, Zhang S, Zhang S, Zhang XD, Zhang XM, Zhang XY, Zhang Y, Zhang YT, Zhang YH, Zhang YM, Zhang Y, Zhang Y, Zhang ZD, Zhang ZH, Zhang ZL, Zhang ZY, Zhang ZY, Zhang ZZ, Zhao G, Zhao JY, Zhao JZ, Zhao L, Zhao L, Zhao MG, Zhao N, Zhao RP, Zhao SJ, Zhao YB, Zhao YX, Zhao ZG, Zhemchugov A, Zheng B, Zheng BM, Zheng JP, Zheng WJ, Zheng YH, Zhong B, Zhong X, Zhou H, Zhou JY, Zhou LP, Zhou S, Zhou X, Zhou XK, Zhou XR, Zhou XY, Zhou YZ, Zhu J, Zhu K, Zhu KJ, Zhu KS, Zhu L, Zhu LX, Zhu SH, Zhu SQ, Zhu TJ, Zhu WD, Zhu YC, Zhu ZA, Zou JH, and Zu J

Abstract

Using data samples collected with the BESIII detector operating at the BEPCII storage ring, the cross section of the inclusive process e^{+}e^{-}→η+X, normalized by the total cross section of e^{+}e^{-}→hadrons, is measured at eight center-of-mass energy points from 2.0000 to 3.6710 GeV. These are the first measurements with momentum dependence in this energy region. Our measurement shows a significant discrepancy compared to the existing fragmentation functions. To address this discrepancy, a new QCD analysis is performed at the next-to-next-to-leading order with hadron mass corrections and higher twist effects, which can explain both the established high-energy data and our measurements reasonably well.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results