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Doxazosin used in benign prostatic hyperplasia has the side effects of causing hypotension and the risk of heart failure. The 3 targets of [α.sub.1A]-adrenoceptors (in the prostate), [α.sub.1D]-adrenoceptors (in the aorta), and an unknown mechanism (in the heart) are involved, respectively. We hypothesized that there is a chiral recognition of doxazosin enantiomers in the 3 targets. Using isolated rat aorta ([α.sub.1D]-adrenoceptors) and rabbit prostate ([α.sub.1A]-adrenoceptors), we examined [pA.sub.2] and [pK.sub.B] values of doxazosin enantiomers. We observed chronotropic and inotropic effects of doxazosin enantiomers in isolated rat and rabbit heart tissues. (-)Doxazosin and (+)doxazosin produced a shift to the right of concentration-contraction curves for noradrenalin (aorta) and phenylephrine (prostate smooth muscle). The [pA.sub.2] value of (-)doxazosin (8.625 [+ or -] 0.053) was smaller than (+)doxazosin (9.503 ± 0.051) in rat aorta, but their [pK.sub.B] values in rabbit prostate were the same. In rat and rabbit heart tissues, (+)doxazosin (3-30 (µmol x [L.sup.-1]) significantly decreased atrial rate, and produced negative inotropic effects; however, (-)doxazosin did not affect the atrial rate, and produced positive inotropic effects in the atria. Thus, the chiral carbon atom of doxazosin does not affect its activity at the therapeutic target of [α.sub.1A]-adrenoceptors in the prostate, but significantly changes its blocking activity against [α.sub.1D]-adrenoceptors in the aorta, and produces opposite inotropic effects in the atria via an [α.sub.1]-adrenoceptor-independent mechanism. Key words: doxazosin, enantiomer, prostate, aorta, heart. La doxazosine utilisee dans l'hyperplasie benigne de la prostate exerce un effet secondaire hypotenseur et un augmente le risque d'insuffisance cardiaque, et trois cibles des recepteurs [α.sub.1A]-adrenergiques (dans la prostate), [α.sub.1D]-adrenergiques (dans l'aorte) ainsi qu'un mecanisme inconnu (dans le coeur) sont respectivement impliques. Nous avons verifie l'hypothese d'une reconnaissance chirale des enantiomeres de la doxazosine par les trois cibles. Nous avons examine les valeurs de [pA.sub.2] et [pK.sub.B] des enantiomeres de la doxazosine sur l'aorte de rat isolee (recepteurs [α.sub.1D]-adrenergiques) et la prostate de lapin (recepteurs [α.sub.1A]-adrenergiques). Nous avons observe les effets chronotopes et inotropes des enantiomeres de la doxazosine sur les tissus cardiaques isoles du rat et du lapin. La (-)doxazosine et la (+)doxazosine deplacaient vers la droite les courbes de concentration-contraction de la noradrenaline (aorte) et de la norepinephrine (muscle lisse de la prostate). La valeur de [pA.sub.2] de la (-)doxazosine (8,625 [+ ou -] 0,053) etait inferieure a celle de la (+)doxazosine (9,503 [+ ou -] 0,051) dans l'aorte de rat, mais leurs valeurs de pKB etaient les memes dans la prostate de lapin. Dans les tissus cardiaques de rat et de lapin, la (+)doxazosine (3-30 (µmol x [L.sup.-1]) diminuait significativement le rythme atrial et exercait des effets inotropes negatifs sur l'atrium ; cependant, la (-)doxazosine n'affectait pas le rythme atrial et exercait des effets inotropes positifs sur l'atrium. Le carbone chiral de la doxazosine n'affecte pas son activite comme cible therapeutique des recepteurs [α.sub.1A]-adrenergiques dans la prostate mais change significativement son activite bloquante envers les recepteurs [α.sub.1A]-adrenergiques dans l'aorte et exerce des effets inotropes opposes dans l'atrium par l'intermediaire d'un mecanisme independant des recepteurs [α.sub.1]-adrenergiques. Mots-cles: doxazosine, enantiomere, prostate, aorte, coeur. [Traduit par la Redaction], Introduction (±)Doxazosin ((±)DOX), a quinazoline based compound, is a long lasting inhibitor of a adrenoceptors that is widely used in the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (LUTS/BPH) [...]

Cinnamomum camphora pigment is made from Cinnamomum camphora leaves and the pericarp in the extraction of red pigment, green pigment and its derivatives, with the activities of antioxidant, antibacterial, fall blood sugar, health care function, etc..It is a kind of natural pigments which is abundant, colour diversity, non-toxic, high stability. It has great application potential and value in the fields of food, textile, pharmaceutical and beverage. In order to further study, better develop and utilize Cinnamomum camphora pigment, the research at home and abroad of Cinnamomum camphora pigment in chemical structure, physical and chemical composition, extraction method, purification and separation, functional activity and application were reviewed in recent years, and the future research direction and application prospect of this pigment were prospected. [ABSTRACT FROM AUTHOR]

This study analyzed the trend in semen quality of infertile male patients in Wenzhou, China, based on the data obtained from 38 905 patients during 2008–2016 in The First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China). The results showed that only 24.9% of the patients had normal semen quality. For the semen quality of infertile male patients, that of the workers and 40-year-olds was significantly worse than the other occupational and age groups. For all the infertile patients, low semen volume, asthenozoospermia, and teratozoospermia accounted for 8.4%, 50.5%, and 54.1%, respectively. During 2008–2016, the annual mean percentage of fast forward motile spermatozoa, percentage of total forward motile spermatozoa, and percentage of spermatozoa with normal morphology decreased linearly with slopes of −2.11, −2.59, and −0.70, respectively. The proportion of patients with asthenozoospermia and multi-abnormal spermatozoa increased during 2008–2016 with slopes of 4.70 and 4.87, respectively, while for low semen volume, it decreased with a slope of −0.47 in the same time period. The proportion of patients with teratozoospermia increased from 2008 to 2011 and from 2011 to 2016 with slopes of 17.10 and 2.09, respectively. In general, the deteriorating trend of semen quality of infertile male patients in Wenzhou was obvious. Future efforts should be made to reveal the adverse influences on semen quality, such as occupational exposure, environmental quality, and living habits. Furthermore, more pervasive reproduction health education is necessary. [ABSTRACT FROM AUTHOR]

In order to improve the anti-noise performance of speech communication system in industrial field, a speech de-noise algorithm based on adaptive filtering was proposed. The algorithm improved the recursive logarithmic least mean pth algorithm, and constructed a positive definite matrix by quasi Newton method for speech de-noise. STM32F429 was taken as the control core to design the hardware of dual channel speech noise reduction system, and the adaptive filtering algorithm processing software was compiled. The experimental verification was carried out. The results show that the proposed algorithm has faster convergence speed and smaller steady-state error than these of RLLMP algorithm and RLS algorithm, which is suitable for the colored noise signal described by a stable distribution. Under the experimental conditions, the signal-noise ratio(SNR) of the de-noise speech signal received is increased by 10 dB and the speech intelligibility is increased by 0.3 on average compared with that of the noise speech signal. It illustrates that this algorithm can effectively reduce the mixed colored noise signal in speech signal and improve the quality of speech signal. [ABSTRACT FROM AUTHOR]