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Abstract: Two kinds of Co3O4 samples with micro/nano-structure as high capacity anode materials for Lithium-ion Batteries are synthesized by a facile method. The structure, composition and surface morphology are analyzed by means of X-ray diffraction (XRD), scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HRTEM), respectively. The XRD data indicates that the two Co3O4 materials are crystalline, single-phase without any impurity phase; the size of spheres and cubes are estimated to be 2 μm and the nanoparticles are around 100 nm. The cyclic voltammetry and discharge/charge measurements are carried out to detect the electrochemical properties. The results demonstrate that the two Co3O4 electrodes with micro/nano-structure exhibit low initial irreversible capacity and superior cycling performance. The two Co3O4 materials with micro/nano-structure are confirmed to combine the advantages of the micro-materials and nano-materials for LIBs. Moreover, the Co3O4 spheres (s-Co3O4) exhibit more superior cycling performance than that of Co3O4 cubes (c-Co3O4) due to the larger void volume in spheres than that in cubes structure. [Copyright &y& Elsevier]

Tropomyosin receptor kinases (TRKs) are associated with the proliferation and differentiation of cells, and thus their continuous activation and overexpression cause cancer. Herein, based on scaffold hopping and computer-aid drug design, 38 pyrazolo[3,4- b ]pyridine derivatives were synthesised. Further, we evaluated their activities to inhibit TRKA. Among them, compound C03 showed acceptable activity with an IC 50 value of 56 nM and it inhibited the proliferation of the Km-12 cell line with an IC 50 value of 0.304 μM together with obvious selectivity for the MCF-7 cell line and HUVEC cell line. Furthermore, compound C03 possessed good plasma stability and low inhibitory activity to a panel of cytochrome P450 isoforms except CYP2C9. Overall, C03 has potential for further exploration., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Herein, facile and enantioselective approaches to synthesize the core phthalide tetrahydroisoquinoline scaffold of (-)-β-hydrastine via both a CF 3 COOH-catalyzed (86% ee) and KHMDS-catalyzed (78% ee) epoxide ring-opening/transesterification cascade cyclization from chiral epoxide under very mild conditions are described. The key elements include a highly enantioselective epoxidation using the Shi ketone catalyst and an intramolecular CF 3 COOH-catalyzed cascade cyclization in one pot, and a late-stage C-3' epimerization under MeOK/MeOH conditions as the key steps to achieve the first total synthesis of (-)-β-hydrastine (up to 81% ee)., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)