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51. Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials

Author

Abbey, Ashkan, Abdulaeva, Elmira, Abraham, Prema, Adan Civera, Alfredo, Agostini, Hansjurgen, Alezzandrini, Arturo, Alfaro, Virgil, Almony, Arghavan, Altay, Lebriz, Amini, Payam, Antoszyk, Andrew, Aradi, Etelka, Arias, Luis, Arnold, Jennifer, Asaria, Riaz, Astakhov, Sergei, Astakhov, Yury, Awh, Carl C., Balaratnasingam, Chandra, Banerjee, Sanjiv, Baumal, Caroline, Becker, Matthias, Belfort, Rubens, Jr., Bratko, Galina, Bridges, William Jr. Z, Brown, Jamin, Brown, David M., Budzinskaya, Maria, Buffet, Sylvia, Burgess, Stuart, Byon, Iksoo, Cagini, Carlo, Calzada, Jorge, Cameron, Stone, Campochiaro, Peter, Carlson, John, Carneiro, Angela, Chan, Clement, Chang, Emmanuel, Chang, Andrew, Chao, Daniel, Chaudhry, Nauman, Chee, Caroline, Cheek, Andrew, Chen, Shih-Jen, Chen, San-Ni, Cheung, Gemmy, Chexal, Saradha, Chittum, Mark, Chow, David, Cole, Abosede, Connolly, Brian, Cornut, Pierre Loic, Couvillion, Stephen, Danzig, Carl, Daskalov, Vesselin, Dessouki, Amr, Devin, Francois, Dollin, Michael, Dolz, Rosa, Downey, Louise, Dreyer, Richard, Dugel, Pravin, Eichenbaum, David, Eldem, Bora, Engstrom, Robert, Escobar, Joan Josep, Eter, Nicole, Faber, David W., Falk, Naomi, Feiner, Leonard, Fernandez Vega, Alvaro, Ferrone, Philip, Figueroa, Marta, Fine, Howard, Fineman, Mitchell, Fox, Gregory M., Francais, Catherine, Franco, Pablo, Fraser-Bell, Samantha, Fung, Nicholas, Furno Sola, Federico, Gale, Richard, Garcia-Layana, Alfredo, Gasperini, Julie, Gawecki, Maciej, Ghanchi, Faruque, Gill, Manjot, Giunta, Michel, Glaser, David, Goldstein, Michaella, Gomez Ulla, Francisco, Gomi, Fumi, Gonzalez, Victor, Graff, Jordan, Gupta, Sunil, Guthoff, Rainer, Guymer, Robyn, Haas, Anton, Hampton, Robert, Hatz, Katja, Hayashi, Ken, Heier, Jeffrey, Herba, Ewa, Hershberger, Vrinda, Higgins, Patrick, Holekamp, Nancy, Honda, Shigeru, Howard, James, Hu, Allen, Huddleston, Stephen, Iida, Tomohiro, Imaizumi, Hiroko, Ito, Yasuo, Ito, Yasuki, Itty, Sujit, Javey, Golnaz, Javid, Cameron, Kaga, Tatsushi, Kaluzny, Jakub, Kang, Se Woong, Kapoor, Kapil, Karabas, Levent, Kawasaki, Tsutomu, Kelty, Patrick, Kerenyi, Agnes, Khanani, Arshad, Khoramnia, Ramin, Khurana, Rahul, Kimura, Kazuhiro, Klein-Mascia, Kendra, Kobayashi, Namie, Kodjikian, Laurent, Koizumi, Hideki, Kokame, Gregg, Kulikov, Alexey, Kwong, Henry, Kwun, Robert, Lai, Timothy, Lai, Chi-Chun, Lalonde, Laurent, Lanzetta, Paolo, Larsen, Michael, Lavina, Adrian, Lee, Won Ki, Lee, ji Eun, Lee, Seong, Levy, Jaime, Lindsell, Lucas, Liu, Mimi, London, Nikolas, Lotery, Andrew, Lozano Rechy, David, Luckie, Alan, Maberley, David, Maeno, Takatoshi, Mahmood, Sajjad, Makkouk, Fuad, Marcus, Dennis, Margherio, Alan, Masse, Helene, Matsubara, Hisashi, Maturi, Raj, Mehta, Sonia, Menon, Geeta, Mentes, Jale, Michels, Mark, Mitamura, Yoshinori, Mitchell, Paul, Mohamed, Quresh, Mones, Jordi, Montemayor Lobo, Rodrigo, Montero, Javier, Moore, Jeffrey, Mori, Ryusaburo, Morori-Katz, Haia, Mukherjee, Raj, Murata, Toshinori, Muzyka-Wozniak, Maria, Nardi, Marco, Narendran, Niro, Nicolo, Massimo, Nielsen, Jared, Nishimura, Tetsuya, Noda, Kousuke, Nowinska, Anna, Oh, Hideyasu, Ohr, Matthew, Okada, Annabelle, Oleksy, Piotr, Ono, Shinji, Ozdek, Sengul, Ozturk, Banu, Pablo, Luis, Park, Kyu Hyung, Parke, D. Wilki, Parravano, Maria Cristina, Patel, Praveen, Patel, Apurva, Patel, Sunil, Patel, Sugat, Pauleikhoff, Daniel, Pearce, Ian, Pearlman, Joel, Petkova, Iva, Pieramici, Dante, Pozdeyeva, Nadezhda, Qureshi, Jawad, Raczynska, Dorota, Ramirez Estudillo, Juan, Rathod, Rajiv, Razavi, Hessam, Regillo, Carl, Reilly, Gayatri, Ricci, Federico, Rich, Ryan, Romanowska-Dixon, Bożena, Rosenblatt, Irit, Ruiz Moreno, Jose Maria, Sacu, Stefan, Saedon, Habiba, Saeed, Usman, Sagong, Min, Sakamoto, Taiji, Sandhu, Sukhpal, Sararols, Laura, Saravia, Mario, Schadlu, Ramin, Schlottmann, Patricio, Sekiryu, Tetsuju, Seres, András, Sermet, Figen, Shah, Sumit, Shah, Rohan, Shah, Ankur, Sheidow, Thomas, Sheth, Veeral, Shiragami, Chieko, Sikorski, Bartosz, Silva, Rufino, Singerman, Lawrence, Sisk, Robert, Sørensen, Torben L., Souied, Eric, Spinak, David-J, Staurenghi, Giovanni, Steinmetz, Robert, Stoller, Glenn, Stoltz, Robert, Suan, Eric, Suner, Ivan, Suzanne, Yzer, Tadayoni, Ramin, Takahashi, Kanji, Takayama, Kei, Taleb, Alexandre, Talks, James, Terasaki, Hiroko, Thompson, John, Toth-Molnar, Edit, Tran, Khoi, Tuli, Raman, Uchiyama, Eduardo, Vajas, Attila, Van Lith-Verhoeven, Janneke, Varsanyi, Balazs, Viola, Francesco, Virgili, Gianni, Vogt, Gábor, Völker, Michael, Warrow, David, Weber, Pamela, Wells, John A., Wickremasinghe, Sanjeewa, Wieland, Mark, Williams, Geoff, Williams, Thomas, Wong, David, Wong, King, Wong, James, Wong, Ian, Wong, Robert, Wowra, Bogumil, Wykoff, Charles C., Yamashita, Ayana, Yasuda, Kanako, Yilmaz, Gursel, Yiu, Glenn, Yoneda, Ai, Yoon, Young Hee, Yoreh, Barak, Yu, HyeongGon, Yu, Seung Young, Yurieva, Tatiana, Zambrano, Alberto, Zatorska, Barbara, Zeolite, Carlos, Heier, Jeffrey S, Khanani, Arshad M, Quezada Ruiz, Carlos, Basu, Karen, Ferrone, Philip J, Brittain, Christopher, Figueroa, Marta S, Lin, Hugh, Holz, Frank G, Patel, Vaibhavi, Lai, Timothy Y Y, Silverman, David, Swaminathan, Balakumar, Cheung, Chui Ming Gemmy, and Wong, Tien Y

Published
2022
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52. Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials

Author

Aaberg, Thomas, Jr, Abbey, Ashkan, Abdulaeva, Elmira, Abengoechea, Santiago, Abraham, Prema, Ach, Thomas, Adams, Serrhel, Adan Civera, Alfredo, Adrean, Sean, Agostini, Hansjurgen, Alam, Suhail, Alezzandrini, Arturo, Alfaro, Virgil, Aliseda, Daniel, Almony, Arghavan, Amat, Pedro, Amini, Payam, Antoszyk, Andrew, Arias, Luis, Asaria, Riaz, Avila, Marcos, Awh, Carl C, Bafalluy, Joaquin, Baker, Carl, Bandello, Francesco, Barakat, Mark, Barraza, Karen, Bator, Gyorgy, Baumal, Caroline, Belfort Jr, Rubens, Bergstrom, Chris, Bertolucci, George, Bochow, Thomas, Bolz, Matthias, Borcz, Emilia, Bordon, Arnaldo, Boyer, David, Bratko, Galina, Brent, Michael, Brown, Jamin, Brown, David M, Budzinskaya, Maria, Buffet, Sylvia, Burgess, Stuart, Burton, Ben, Busquets, Miguel, Cabrera, Francisco, Cagini, Carlo, Calzada, Jorge, Campochiaro, Peter, Carlson, John, Castellarin, Alessandro, Cava, Carlos, Chaikitmongkol, Voraporn, Chan, Clement, Chang, Emmanuel, Chang, Jonathan, Chang, Andrew, Charles, Steve, Chaudhry, Nauman, Chee, Caroline, Chen, Judy, Chen, Fred, Chen, Shih-Jen, Cheong-Leen, Richard, Chiang, Allen, Chittum, Mark, Chow, David, Connolly, Brian, Cornut, Pierre Loic, Csaky, Karl, Danzig, Carl, Das, Arup, Daskalov, Vesselin, Desco, Carmen, Dessouki, Amr, Dickinson, John, Do, Brian, Dollin, Michael, Dugel, Pravin, Dusova, Jaroslava, Eichenbaum, David, Eldem, Bora, Engstrom, Robert, Ernest, Jan, Escobar, Joan Josep, Esposti, Simona, Eter, Nicole, Falk, Naomi, Farkas, Andrej, Feiner, Leonard, Feltgen, Nicolas, Fernandez, Carlos, Fernandez Vega, Alvaro, Ferrone, Philip, Figueira, Joao, Figueroa, Marta, Findl, .Oliver, Fine, Howard, Fortun, Jorge, Fox, Gregory M, Foxman, Scott, Framme, Carsten, Fraser-Bell, Samantha, Fu, Arthur, Fukutomi, Akira, Fung, Nicholas, Furno Sola, Federico, Gallego-Pinazo, Roberto, Garcia, Renata, Garcia-Layana, Alfredo, Gawecki, Maciej, George, Sheen, Ghanchi, Faruque, Ghorayeb, Ghassan, Goldberg, Roger, Goldstein, Michaella, Gomes, Nuno, Gomez Ulla, Francisco, Gonzalez, Victor, Greven, Craig, Gupta, Sunil, Guzman, Miguel, Harris, Martin, Hatz, Katja, Hau, Vivienne, Hau, Vincent, Hayashi, Ken, Heier, Jeffrey, Herba, Ewa, Hershberger, Vrinda, Higgins, Patrick, Hirakata, Akito, Ho, Allen, Holekamp, Nancy, Honda, Shigeru, Hsu, Jason, Hu, Allen, Hurcikova, Maria, Ikeda, Yasuhiro, Isernhagen, Ricky, Ito, Yasuki, Jackson, Tim, Jacoby, Rachael, Jafree, Afsar, Javey, Golnaz, Javid, Cameron, Jhaveri, Chirag, Johnson, Mark, Kacerík, Marek, Kaluzny, Jakub, Kampik, Daniel, Kang, Se Woong, Kapoor, Kapil, Karabas, Levent, Kawasaki, Tsutomu, Kerenyi, Agnes, Khanani, Arshad, Khurana, Rahul, Kim, Brian, Kimura, Kazuhiro, Kishino, Genichiro, Kitano, Shigehiko, Klein-Mascia, Kendra, Kokame, Gregg, Korobelnik, Jean Francois, Kulikov, Alexey, Kuriyan, Ajay, Kwong, Henry, Kwun, Robert, Lai, Timothy, Lai, Chi-Chun, Laird, Philip, Lalonde, Laurent, Lanzetta, Paolo, Larsen, Michael, Laugesen, Caroline, Lavinsky, Daniel, Lebreton, Olivier, Lee, Seong, Levy, Jaime, Lipkova, Blandina, Liu, Mimi, Liu, Judy, Lohmann, Chris P, London, Nikolas, Lorenz, Katrin, Lotery, Andrew, Lozano Rechy, David, Lujan, Silvio, Ma, Patrick, Maeno, Takatoshi, Mahmood, Sajjad, Makkouk, Fuad, Malik, Khurram, Marcus, Dennis, Margherio, Alan, Mastropasqua, Leonardo, Maturi, Raj, McCabe, Frank, McKibbin, Martin, Mehta, Hemal, Menon, Geeta, Mentes, Jale, Michalska-Malecka, Katarzyna, Misheva, Aneta, Mitamura, Yoshinori, Mitchell, Paul, Modi, Yasha, Mohamed, Quresh, Montero, Javier, Moore, Jeffrey, Morales Canton, Virgilio, Morori-Katz, Haia, Morugova, Tatiana, Murakami, Tomoaki, Muzyka-Wozniak, Maria, Nardi, Marco, Nemcansky, Jan, Nester-Ostrowska, Kamila, Neto, Julio, Newell, Charles, Nicolo, Massimo, Nielsen, Jared, Noda, Kousuke, Obana, Akira, Ogata, Nahoko, Oh, Hideyasu, Oh, Kean, Ohr, Matthew, Oleksy, Piotr, Oliver, Scott, Olivier, Sebastien, Osher, James, Ozcalişkan, Sehnaz, Ozturk, Banu, Papp, Andras, Park, Kyu Hyung, Parke, D Wilkin, Parravano, Maria Cristina, Patel, Sugat, Patel, Sunil, Pearce, Ian, Pearlman, Joel, Penha, Fernando, Perente, Irfan, Perkins, Stephen, Pertile, Grazia, Petkova, Iva, Peto, Tunde, Pieramici, Dante, Pollreisz, Andreas, Pongsachareonnont, Pear, Pozdeyeva, Nadezhda, Priglinger, Siegfried, Qureshi, Jawad, Raczynska, Dorota, Rajagopalan, Rajesh, Ramirez Estudillo, Juan, Raskauskas, Paul, Rathod, Rajiv, Razavi, Hessam, Regillo, Carl, Ricci, Federico, Rofagha, Soraya, Romanczak, Dominika, Romanowska-Dixon, Bożena, Rosberger, Daniel, Rosenblatt, Irit, Rosenblatt, Brett, Ross, Adam, Ruamviboonsuk, Paisan, Ruiz Moreno, Jose Maria, Salomão, Gustavo, Sandhu, Sukhpal, Sandner, Dirk, Sararols, Laura, Sawada, Osamu, Schadlu, Ramin, Schlottmann, Patricio, Schuart, Claudia, Seitz, Berthold, Seres, András, Sermet, Figen, Shah, Sandeep, Shah, Ankur, Shah, Rohan, Sharma, Sumit, Sheidow, Thomas, Sheth, Veeral, Shimouchi, Akito, Shimura, Masahiko, Sikorski, Bartosz, Silva, Rufino, Singer, Michael, Singerman, Lawrence, Singh, Rishi, Souied, Eric, Spinak, David J, Spital, Georg, Steinle, Nathan, Stern, Jeffrey, Stoller, Glenn, Stoltz, Robert, Stone, Cameron, Stone, Amy, Suan, Eric, Sugimoto, Masahiko, Sugita, Iichiro, Sun, Jennifer, Sun, Xiaodong, Suner, Ivan, Szalczer, Lajos, Szecsko, Timea, Tabassian, Ali, Tadayoni, Ramin, Takagi, Hitoshi, Takayama, Kei, Taleb, Alexandre, Talks, James, Tan, Gavin, Tanabe, Teruyo, Taylor, Stanford, Thach, Allen, Thompson, John, Tlucek, Paul, Torti, Robert, Tosheva Guneva, Daniela, Toth-Molnar, Edit, Uchiyama, Eduardo, Vajas, Attila, Varma, Deepali, Varsanyi, Balazs, Vassileva, Petja, Vaz-Pereira, Sara, Veith, Miroslav, Vela, Jose Ignacio, Viola, Francesco, Virgili, Gianni, Vogt, Gábor, Vorum, Henrik, Weber, Pamela, Wecke, Thoalf, Wee, Raymond, Weger, Martin, Weishaar, Paul, Wells, John A, Wickremasinghe, Sanjeewa, Williams, Thomas Reginald, Williams, Thomas, Williams, Geoff, Wolf, Armin, Wolfe, Jeremy, Wong, James, Wong, David, Wong, Ian, Wong, Robert, Wowra, Bogumil, Wykoff, Charles C, Wylęgała, Edward, Yang, Chang-Hao, Yasukawa, Tsutomu, Yates, Paul, Yilmaz, Gursel, Yiu, Glenn, Yoon, Young Hee, Yoreh, Barak, Yoshida, Shigeo, Yu, Hyeong Gon, Yu, Seung Young, Yurieva, Tatiana, Zacharias, Leandro, Zaczek Zakrzewska, Karolina, Zambrano, Alberto, Zatorska, Barbara, Zeolite, Carlos, Zheutlin, Jeffrey, Abreu, Francis, Adamis, Anthony P, Basu, Karen, Eichenbaum, David A, Haskova, Zdenka, Lin, Hugh, Loewenstein, Anat, Mohan, Shaun, Pearce, Ian A, Sakamoto, Taiji, Schlottmann, Patricio G, Silverman, David, Sun, Jennifer K, and Willis, Jeffrey R

Published
2022
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55. Variable Modified Newtonian Mechanics I: Single Metric Universe

Author

Wong, James C. C. and Rivers, Ray J.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

A few years ago Baker \cite{baker} proposed a metric which interpolates smoothly between the Schwarzschild metric at small scales and the Friedmann-Lema$\hat{i}$tre-Robertson - Walker (FLRW) metric at large scales which was rejected as incompatible with Newtonian solar system data. Based on the adiabatic approximation, we find a unique solution within the variants of the same construction scheme which avoids this problem. In this metric, a MOND-like non-Newtonian acceleration arises, which we have termed VMOND, where the MOND acceleration $a_0$ is replaced by a cosmological acceleration which depends on the background matter density. We give two circumstances in which VMOND mimics MOND without the need for additional dark matter. 1) We show that a reasonable over-density at recombination, normally considered too small without additional mass, is enhanced by the effects of VMOND, sufficiently to permit turnaround and collapse to a tight central region before $z\sim 14$. 2) We consider a Milky Way mass over-density at turnaround radius which picks up a systematic maximum angular momentum per unit mass. When the overdensity radius contracts to galactic disk size, we find that the rotating speed follows the Tully Fisher relation with an acceleration scale that is again close to the MOND acceleration $a_0$. This is not a universal panacea to the problems encouraging dark matter but, we suggest, presents a new baseline for calculation. One of us (CCW) has already taken these two points of the model further. Here we are concentrating on the basics., Comment: pages 32, 0 figures

Published
2016

59. Behind closed doors

Author

Wong, James

Subjects
Business, Science and technology
Abstract

Houseplants are having a moment, but there is no need to worry about keeping them in your bedroom at night, says James Wong ONE of my favourite old-school gardening beliefs, [...]

Published
2023

62. Sustainability Balance

Author

Ho, Oanh Thi-Kieu, Iyer-Raniga, Usha, Wong, James P. C., Mifsud, Mark C., Section editor, and Leal Filho, Walter, editor

Published
2019
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64. TENAYA and LUCERNE

Author

Khanani, Arshad M., primary, Kotecha, Aachal, additional, Chang, Andrew, additional, Chen, Shih-Jen, additional, Chen, Youxin, additional, Guymer, Robyn, additional, Heier, Jeffrey S., additional, Holz, Frank G., additional, Iida, Tomohiro, additional, Ives, Jane A., additional, Lim, Jennifer I., additional, Lin, Hugh, additional, Michels, Stephan, additional, Quezada Ruiz, Carlos, additional, Schmidt-Erfurth, Ursula, additional, Silverman, David, additional, Singh, Rishi, additional, Swaminathan, Balakumar, additional, Willis, Jeffrey R., additional, Tadayoni, Ramin, additional, Abbey, Ashkan, additional, Abdulaeva, Elmira, additional, Abraham, Prema, additional, Adan Civera, Alfredo, additional, Agostini, Hansjurgen, additional, Alezzandrini, Arturo, additional, Alfaro, Virgil, additional, Almony, Arghavan, additional, Altay, Lebriz, additional, Amini, Payam, additional, Antoszyk, Andrew, additional, Aradi, Etelka, additional, Arias, Luis, additional, Arnold, Jennifer, additional, Asaria, Riaz, additional, Astakhov, Sergei, additional, Astakhov, Yury, additional, Awh, Carl C., additional, Balaratnasingam, Chandra, additional, Banerjee, Sanjiv, additional, Baumal, Caroline, additional, Becker, Matthias, additional, Belfort, Rubens, additional, Bratko, Galina, additional, Bridges, William Z., additional, Brown, Jamin, additional, Brown, David M., additional, Budzinskaya, Maria, additional, Buffet, Sylvia, additional, Burgess, Stuart, additional, Byon, Iksoo, additional, Cagini, Carlo, additional, Calzada, Jorge, additional, Cameron, Stone, additional, Campochiaro, Peter, additional, Carlson, John, additional, Carneiro, Angela, additional, Chan, Clement, additional, Chang, Emmanuel, additional, Chao, Daniel, additional, Chaudhry, Nauman, additional, Chee, Caroline, additional, Cheek, Andrew, additional, Chen, San-Ni, additional, Cheung, Gemmy, additional, Chexal, Saradha, additional, Chittum, Mark, additional, Chow, David, additional, Cole, Abosede, additional, Connolly, Brian, additional, Cornut, Pierre Loic, additional, Couvillion, Stephen, additional, Danzig, Carl, additional, Daskalov, Vesselin, additional, Dessouki, Amr, additional, Devin, Francois, additional, Dollin, Michael, additional, Dolz, Rosa, additional, Downey, Louise, additional, Dreyer, Richard, additional, Dugel, Pravin, additional, Eichenbaum, David, additional, Eldem, Bora, additional, Engstrom, Robert, additional, Escobar, Joan Josep, additional, Eter, Nicole, additional, Faber, David W., additional, Falk, Naomi, additional, Feiner, Leonard, additional, Vega, Alvaro Fernandez, additional, Ferrone, Philip, additional, Figueroa, Marta, additional, Fine, Howard, additional, Fineman, Mitchell, additional, Fox, Gregory M., additional, Francais, Catherine, additional, Franco, Pablo, additional, Fraser-Bell, Samantha, additional, Fung, Nicholas, additional, Sola, Federico Furno, additional, Gale, Richard, additional, Garcia-Layana, Alfredo, additional, Gasperini, Julie, additional, Gawecki, Maciej, additional, Ghanchi, Faruque, additional, Gill, Manjot, additional, Giunta, Michel, additional, Glaser, David, additional, Goldstein, Michaella, additional, Ulla, Francisco Gomez, additional, Gomi, Fumi, additional, Gonzalez, Victor, additional, Graff, Jordan, additional, Gupta, Sunil, additional, Guthoff, Rainer, additional, Haas, Anton, additional, Hampton, Robert, additional, Hatz, Katja, additional, Hayashi, Ken, additional, Heier, Jeffrey, additional, Herba, Ewa, additional, Hershberger, Vrinda, additional, Higgins, Patrick, additional, Holekamp, Nancy, additional, Honda, Shigeru, additional, Howard, James, additional, Hu, Allen, additional, Huddleston, Stephen, additional, Imaizumi, Hiroko, additional, Ito, Yasuo, additional, Ito, Yasuki, additional, Itty, Sujit, additional, Javey, Golnaz, additional, Javid, Cameron, additional, Kaga, Tatsushi, additional, Kaluzny, Jakub, additional, Kang, Se Woong, additional, Kapoor, Kapil, additional, Karabas, Levent, additional, Kawasaki, Tsutomu, additional, Kelty, Patrick, additional, Kerenyi, Agnes, additional, Khanani, Arshad, additional, Khoramnia, Ramin, additional, Khurana, Rahul, additional, Kimura, Kazuhiro, additional, Klein-Mascia, Kendra, additional, Kobayashi, Namie, additional, Kodjikian, Laurent, additional, Koizumi, Hideki, additional, Kokame, Gregg, additional, Kulikov, Alexey, additional, Kwong, Henry, additional, Kwun, Robert, additional, Lai, Timothy, additional, Lai, Chi-Chun, additional, Lalonde, Laurent, additional, Lanzetta, Paolo, additional, Larsen, Michael, additional, Lavina, Adrian, additional, Lee, Won Ki, additional, Lee, ji Eun, additional, Lee, Seong, additional, Levy, Jaime, additional, Lindsell, Lucas, additional, Liu, Mimi, additional, London, Nikolas, additional, Lotery, Andrew, additional, Lozano Rechy, David, additional, Luckie, Alan, additional, Maberley, David, additional, Maeno, Takatoshi, additional, Mahmood, Sajjad, additional, Makkouk, Fuad, additional, Marcus, Dennis, additional, Margherio, Alan, additional, Masse, Helene, additional, Matsubara, Hisashi, additional, Maturi, Raj, additional, Mehta, Sonia, additional, Menon, Geeta, additional, Mentes, Jale, additional, Michels, Mark, additional, Mitamura, Yoshinori, additional, Mitchell, Paul, additional, Mohamed, Quresh, additional, Mones, Jordi, additional, Lobo, Rodrigo Montemayor, additional, Montero, Javier, additional, Moore, Jeffrey, additional, Mori, Ryusaburo, additional, Morori-Katz, Haia, additional, Mukherjee, Raj, additional, Murata, Toshinori, additional, Muzyka-Wozniak, Maria, additional, Nardi, Marco, additional, Narendran, Niro, additional, Nicolo, Massimo, additional, Nielsen, Jared, additional, Nishimura, Tetsuya, additional, Noda, Kousuke, additional, Nowinska, Anna, additional, Oh, Hideyasu, additional, Ohr, Matthew, additional, Okada, Annabelle, additional, Oleksy, Piotr, additional, Ono, Shinji, additional, Ozdek, Sengul, additional, Ozturk, Banu, additional, Pablo, Luis, additional, Park, Kyu Hyung, additional, Parke, D. Wilk, additional, Parravano, Maria Cristina, additional, Patel, Praveen, additional, Patel, Apurva, additional, Patel, Sunil, additional, Patel, Sugat, additional, Pauleikhoff, Daniel, additional, Pearce, Ian, additional, Pearlman, Joel, additional, Petkova, Iva, additional, Pieramici, Dante, additional, Pozdeyeva, Nadezhda, additional, Qureshi, Jawad, additional, Raczynska, Dorota, additional, Ramirez Estudillo, Juan, additional, Rathod, Rajiv, additional, Razavi, Hessam, additional, Regillo, Carl, additional, Reilly, Gayatri, additional, Ricci, Federico, additional, Rich, Ryan, additional, Romanowska-Dixon, Bożena, additional, Rosenblatt, Irit, additional, Ruiz Moreno, Jose Maria, additional, Sacu, Stefan, additional, Saedon, Habiba, additional, Saeed, Usman, additional, Sagong, Min, additional, Sakamoto, Taiji, additional, Sandhu, Sukhpal, additional, Sararols, Laura, additional, Saravia, Mario, additional, Schadlu, Ramin, additional, Schlottmann, Patricio, additional, Sekiryu, Tetsuju, additional, Seres, András, additional, Sermet, Figen, additional, Shah, Sumit, additional, Shah, Rohan, additional, Shah, Ankur, additional, Sheidow, Thomas, additional, Sheth, Veeral, additional, Shiragami, Chieko, additional, Sikorski, Bartosz, additional, Silva, Rufino, additional, Singerman, Lawrence, additional, Sisk, Robert, additional, Sørensen, Torben L., additional, Souied, Eric, additional, Spinak, David-J., additional, Staurenghi, Giovanni, additional, Steinmetz, Robert, additional, Stoller, Glenn, additional, Stoltz, Robert, additional, Suan, Eric, additional, Suner, Ivan, additional, Yzer, Suzanne, additional, Takahashi, Kanji, additional, Takayama, Kei, additional, Taleb, Alexandre, additional, Talks, James, additional, Terasaki, Hiroko, additional, Thompson, John, additional, Toth-Molnar, Edit, additional, Tran, Khoi, additional, Tuli, Raman, additional, Uchiyama, Eduardo, additional, Vajas, Attila, additional, Lith-Verhoeven, Janneke Van, additional, Varsanyi, Balazs, additional, Viola, Francesco, additional, Virgili, Gianni, additional, Vogt, Gábor, additional, Völker, Michael, additional, Warrow, David, additional, Weber, Pamela, additional, Wells, John A., additional, Wickremasinghe, Sanjeewa, additional, Wieland, Mark, additional, Williams, Geoff, additional, Williams, Thomas, additional, Wong, David, additional, Wong, King, additional, Wong, James, additional, Wong, Ian, additional, Wong, Robert, additional, Wowra, Bogumil, additional, Wykoff, Charles C., additional, Yamashita, Ayana, additional, Yasuda, Kanako, additional, Yilmaz, Gursel, additional, Yiu, Glenn, additional, Yoneda, Ai, additional, Yoon, Young Hee, additional, Yoreh, Barak, additional, Yu, Hyeong Gon, additional, Yu, Seung Young, additional, Yurieva, Tatiana, additional, Zambrano, Alberto, additional, Zatorska, Barbara, additional, and Zeolite, Carlos, additional

Published
2024
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70. Faricimab Treat-and-Extend for Diabetic Macular Edema

Author

Wong, Tien Y., primary, Haskova, Zdenka, additional, Asik, Kemal, additional, Baumal, Caroline R., additional, Csaky, Karl G., additional, Eter, Nicole, additional, Ives, Jane A., additional, Jaffe, Glenn J., additional, Korobelnik, Jean-François, additional, Lin, Hugh, additional, Murata, Toshinori, additional, Ruamviboonsuk, Paisan, additional, Schlottmann, Patricio G., additional, Seres, András I., additional, Silverman, David, additional, Sun, Xiaodong, additional, Tang, Yannan, additional, Wells, John A., additional, Yoon, Young Hee, additional, Wykoff, Charles C., additional, Aaberg, Thomas, additional, Abbey, Ashkan, additional, Abdulaeva, Elmira, additional, Abengoechea, Santiago, additional, Abraham, Prema, additional, Ach, Thomas, additional, Adams, Serrhel, additional, Adan Civera, Alfredo, additional, Adrean, Sean, additional, Agostini, Hansjurgen, additional, Alam, Suhail, additional, Alezzandrini, Arturo, additional, Alfaro, Virgil, additional, Aliseda, Daniel, additional, Almony, Arghavan, additional, Amat, Pedro, additional, Amini, Payam, additional, Antoszyk, Andrew, additional, Arias, Luis, additional, Asaria, Riaz, additional, Avila, Marcos, additional, Awh, Carl C., additional, Bafalluy, Joaquin, additional, Baker, Carl, additional, Bandello, Francesco, additional, Barakat, Mark, additional, Barraza, Karen, additional, Bator, Gyorgy, additional, Baumal, Caroline, additional, Belfort, Rubens, additional, Bergstrom, Chris, additional, Bertolucci, George, additional, Bochow, Thomas, additional, Bolz, Matthias, additional, Borcz, Emilia, additional, Bordon, Arnaldo, additional, Boyer, David, additional, Bratko, Galina, additional, Brent, Michael, additional, Brown, Jamin, additional, Brown, David M., additional, Budzinskaya, Maria, additional, Buffet, Sylvia, additional, Burgess, Stuart, additional, Burton, Ben, additional, Busquets, Miguel, additional, Cabrera, Francisco, additional, Cagini, Carlo, additional, Calzada, Jorge, additional, Campochiaro, Peter, additional, Carlson, John, additional, Castellarin, Alessandro, additional, Cava, Carlos, additional, Chaikitmongkol, Voraporn, additional, Chan, Clement, additional, Chang, Emmanuel, additional, Chang, Jonathan, additional, Chang, Andrew, additional, Charles, Steve, additional, Chaudhry, Nauman, additional, Chee, Caroline, additional, Chen, Judy, additional, Chen, Fred, additional, Chen, Shih-Jen, additional, Cheong-Leen, Richard, additional, Chiang, Allen, additional, Chittum, Mark, additional, Chow, David, additional, Connolly, Brian, additional, Cornut, Pierre Loic, additional, Csaky, Karl, additional, Danzig, Carl, additional, Das, Arup, additional, Daskalov, Vesselin, additional, Desco, Carmen, additional, Dessouki, Amr, additional, Dickinson, John, additional, Do, Brian, additional, Dollin, Michael, additional, Dugel, Pravin, additional, Dusova, Jaroslava, additional, Eichenbaum, David, additional, Eldem, Bora, additional, Engstrom, Robert, additional, Ernest, Jan, additional, Escobar, Joan Josep, additional, Esposti, Simona, additional, Falk, Naomi, additional, Farkas, Andrej, additional, Feiner, Leonard, additional, Feltgen, Nicolas, additional, Fernandez, Carlos, additional, Fernandez Vega, Alvaro, additional, Ferrone, Philip, additional, Figueira, Joao, additional, Figueroa, Marta, additional, Findl, Oliver, additional, Fine, Howard, additional, Fortun, Jorge, additional, Fox, Gregory M., additional, Foxman, Scott, additional, Framme, Carsten, additional, Fraser-Bell, Samantha, additional, Fu, Arthur, additional, Fukutomi, Akira, additional, Fung, Nicholas, additional, Furno Sola, Federico, additional, Gallego-Pinazo, Roberto, additional, Garcia, Renata, additional, Garcia-Layana, Alfredo, additional, Gawecki, Maciej, additional, George, Sheen, additional, Ghanchi, Faruque, additional, Ghorayeb, Ghassan, additional, Goldberg, Roger, additional, Goldstein, Michaella, additional, Gomes, Nuno, additional, Ulla, Francisco Gomez, additional, Gonzalez, Victor, additional, Greven, Craig, additional, Gupta, Sunil, additional, Guzman, Miguel, additional, Harris, Martin, additional, Hatz, Katja, additional, Hau, Vivienne, additional, Hau, Vincent, additional, Hayashi, Ken, additional, Heier, Jeffrey, additional, Herba, Ewa, additional, Hershberger, Vrinda, additional, Higgins, Patrick, additional, Hirakata, Akito, additional, Ho, Allen, additional, Holekamp, Nancy, additional, Honda, Shigeru, additional, Hsu, Jason, additional, Hu, Allen, additional, Hurcikova, Maria, additional, Ikeda, Yasuhiro, additional, Isernhagen, Ricky, additional, Ito, Yasuki, additional, Jackson, Tim, additional, Jacoby, Rachael, additional, Jafree, Afsar, additional, Javey, Golnaz, additional, Javid, Cameron, additional, Jhaveri, Chirag, additional, Johnson, Mark, additional, Kacerík, Marek, additional, Kaluzny, Jakub, additional, Kampik, Daniel, additional, Kang, Se Woong, additional, Kapoor, Kapil, additional, Karabas, Levent, additional, Kawasaki, Tsutomu, additional, Kerenyi, Agnes, additional, Khanani, Arshad, additional, Khurana, Rahul, additional, Kim, Brian, additional, Kimura, Kazuhiro, additional, Kishino, Genichiro, additional, Kitano, Shigehiko, additional, Klein-Mascia, Kendra, additional, Kokame, Gregg, additional, Korobelnik, Jean Francois, additional, Kulikov, Alexey, additional, Kuriyan, Ajay, additional, Kwong, Henry, additional, Kwun, Robert, additional, Lai, Timothy, additional, Lai, Chi-Chun, additional, Laird, Philip, additional, Lalonde, Laurent, additional, Lanzetta, Paolo, additional, Larsen, Michael, additional, Laugesen, Caroline, additional, Lavinsky, Daniel, additional, Lebreton, Olivier, additional, Lee, Seong, additional, Levy, Jaime, additional, Lipkova, Blandina, additional, Liu, Mimi, additional, Liu, Judy, additional, Lohmann, Chris P., additional, London, Nikolas, additional, Lorenz, Katrin, additional, Lotery, Andrew, additional, Lozano Rechy, David, additional, Lujan, Silvio, additional, Ma, Patrick, additional, Maeno, Takatoshi, additional, Mahmood, Sajjad, additional, Makkouk, Fuad, additional, Malik, Khurram, additional, Marcus, Dennis, additional, Margherio, Alan, additional, Mastropasqua, Leonardo, additional, Maturi, Raj, additional, McCabe, Frank, additional, McKibbin, Martin, additional, Mehta, Hemal, additional, Menon, Geeta, additional, Mentes, Jale, additional, Michalska-Malecka, Katarzyna, additional, Misheva, Aneta, additional, Mitamura, Yoshinori, additional, Mitchell, Paul, additional, Modi, Yasha, additional, Mohamed, Quresh, additional, Montero, Javier, additional, Moore, Jeffrey, additional, Morales Canton, Virgilio, additional, Morori-Katz, Haia, additional, Morugova, Tatiana, additional, Murakami, Tomoaki, additional, Muzyka-Wozniak, Maria, additional, Nardi, Marco, additional, Nemcansky, Jan, additional, Nester-Ostrowska, Kamila, additional, Neto, Julio, additional, Newell, Charles, additional, Nicolo, Massimo, additional, Nielsen, Jared, additional, Noda, Kousuke, additional, Obana, Akira, additional, Ogata, Nahoko, additional, Oh, Hideyasu, additional, Oh, Kean, additional, Ohr, Matthew, additional, Oleksy, Piotr, additional, Oliver, Scott, additional, Olivier, Sebastien, additional, Osher, James, additional, Ozcalışkan, Sehnaz, additional, Ozturk, Banu, additional, Papp, Andras, additional, Park, Kyu Hyung, additional, Parke, D. Wilkin, additional, Parravano, Maria Cristina, additional, Patel, Sugat, additional, Patel, Sunil, additional, Pearce, Ian, additional, Pearlman, Joel, additional, Penha, Fernando, additional, Perente, Irfan, additional, Perkins, Stephen, additional, Pertile, Grazia, additional, Petkova, Iva, additional, Peto, Tunde, additional, Pieramici, Dante, additional, Pollreisz, Andreas, additional, Pongsachareonnont, Pear, additional, Pozdeyeva, Nadezhda, additional, Priglinger, Siegfried, additional, Qureshi, Jawad, additional, Raczynska, Dorota, additional, Rajagopalan, Rajesh, additional, Ramirez Estudillo, Juan, additional, Raskauskas, Paul, additional, Rathod, Rajiv, additional, Razavi, Hessam, additional, Regillo, Carl, additional, Ricci, Federico, additional, Rofagha, Soraya, additional, Romanczak, Dominika, additional, Romanowska-Dixon, Bożena, additional, Rosberger, Daniel, additional, Rosenblatt, Irit, additional, Rosenblatt, Brett, additional, Ross, Adam, additional, Ruiz Moreno, Jose Maria, additional, Salomão, Gustavo, additional, Sandhu, Sukhpal, additional, Sandner, Dirk, additional, Sararols, Laura, additional, Sawada, Osamu, additional, Schadlu, Ramin, additional, Schlottmann, Patricio, additional, Schuart, Claudia, additional, Seitz, Berthold, additional, Seres, András, additional, Sermet, Figen, additional, Shah, Sandeep, additional, Shah, Ankur, additional, Shah, Rohan, additional, Sharma, Sumit, additional, Sheidow, Thomas, additional, Sheth, Veeral, additional, Shimouchi, Akito, additional, Shimura, Masahiko, additional, Sikorski, Bartosz, additional, Silva, Rufino, additional, Singer, Michael, additional, Singerman, Lawrence, additional, Singh, Rishi, additional, Souied, Eric, additional, Spinak, David J., additional, Spital, Georg, additional, Steinle, Nathan, additional, Stern, Jeffrey, additional, Stoller, Glenn, additional, Stoltz, Robert, additional, Stone, Cameron, additional, Stone, Amy, additional, Suan, Eric, additional, Sugimoto, Masahiko, additional, Sugita, Iichiro, additional, Sun, Jennifer, additional, Suner, Ivan, additional, Szalczer, Lajos, additional, Szecsko, Timea, additional, Tabassian, Ali, additional, Tadayoni, Ramin, additional, Takagi, Hitoshi, additional, Takayama, Kei, additional, Taleb, Alexandre, additional, Talks, James, additional, Tan, Gavin, additional, Tanabe, Teruyo, additional, Taylor, Stanford, additional, Thach, Allen, additional, Thompson, John, additional, Tlucek, Paul, additional, Torti, Robert, additional, Tosheva Guneva, Daniela, additional, Toth-Molnar, Edit, additional, Uchiyama, Eduardo, additional, Vajas, Attila, additional, Varma, Deepali, additional, Varsanyi, Balazs, additional, Vassileva, Petja, additional, Vaz-Pereira, Sara, additional, Veith, Miroslav, additional, Vela, Jose Ignacio, additional, Viola, Francesco, additional, Virgili, Gianni, additional, Vogt, Gábor, additional, Vorum, Henrik, additional, Weber, Pamela, additional, Wecke, Thoalf, additional, Wee, Raymond, additional, Weger, Martin, additional, Weishaar, Paul, additional, Wickremasinghe, Sanjeewa, additional, Williams, Thomas Reginald, additional, Williams, Thomas, additional, Williams, Geoff, additional, Wolf, Armin, additional, Wolfe, Jeremy, additional, Wong, James, additional, Wong, David, additional, Wong, Ian, additional, Wong, Robert, additional, Wowra, Bogumil, additional, Wylęgała, Edward, additional, Yang, Chang-Hao, additional, Yasukawa, Tsutomu, additional, Yates, Paul, additional, Yilmaz, Gursel, additional, Yiu, Glenn, additional, Yoreh, Barak, additional, Yoshida, Shigeo, additional, Yu, Hyeong Gon, additional, Yu, Seung Young, additional, Yurieva, Tatiana, additional, Zacharias, Leandro, additional, Zaczek Zakrzewska, Karolina, additional, Zambrano, Alberto, additional, Zatorska, Barbara, additional, Zeolite, Carlos, additional, and Zheutlin, Jeffrey, additional

Published
2023
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73. Comparing rapid micro-induction and standard induction of buprenorphine/naloxone for treatment of opioid use disorder: protocol for an open-label, parallel-group, superiority, randomized controlled trial

Author

Wong, James S. H., Nikoo, Mohammadali, Westenberg, Jean N., Suen, Janet G., Wong, Jennifer Y. C., Krausz, Reinhard M., Schütz, Christian G., Vogel, Marc, Sidhu, Jesse A., Moe, Jessica, Arishenkoff, Shane, Griesdale, Donald, Mathew, Nickie, and Azar, Pouya

Published
2021
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75. Myocardial involvement in children with post-COVID multisystem inflammatory syndrome: a cardiovascular magnetic resonance based multicenter international study—the CARDOVID registry

Author

Aeschlimann, Florence A., Misra, Nilanjana, Hussein, Tarique, Panaioli, Elena, Soslow, Jonathan H., Crum, Kimberly, Steele, Jeremy M., Huber, Steffen, Marcora, Simona, Brambilla, Paolo, Jain, Supriya, Navallas, Maria, Giuli, Valentina, Rücker, Beate, Angst, Felix, Patel, Mehul D., Azarine, Arshid, Caro-Domínguez, Pablo, Cavaliere, Annachiara, Di Salvo, Giovanni, Ferroni, Francesca, Agnoletti, Gabriella, Bonnemains, Laurent, Martins, Duarte, Boddaert, Nathalie, Wong, James, Pushparajah, Kuberan, and Raimondi, Francesca

Published
2021
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76. Effects of ground granulated blast-furnace slag (GGBS) on hydrological responses of Cd-contaminated soil planted with a herbal medicinal plant (Pinellia ternata)

Author

Ng, Charles Wang Wai, Chowdhury, Nilufar, and Wong, James Tsz Fung

Subjects
Soil moisture -- Physiological aspects, Hydrology -- Physiological aspects, Soil pollution -- Physiological aspects, Medicine, Botanic -- Physiological aspects, Explosions -- Physiological aspects, Medicinal plants -- Physiological aspects -- Production management, Medicine, Herbal -- Physiological aspects, Earth sciences
Abstract

Pinellia ternata is a medicinal herb often contaminated by cadmium (Cd), which inhibits its growth and metabolism. In this study, ground granulated blast-furnace slag (GGBS) is proposed as a soil amendment to reduce plant Cd availability and therefore increase transpiration-induced suction. Field soil (silty gravelly sand) contaminated with 1.5 mg * [kg.sup.-1] of Cd was collected from Guizhou, China. The growth of P. ternata in 0%, 3%, and 5% GGBS amended soil has been investigated in a temperature- and humidity-controlled chamber. Soil amended with 3% and 5% GGBS significantly (P < 0.05, where P is probability) increased leaf area index (LAI) by 29% and 30%, root area index (RAI) by 65% and 66%, respectively, compared to untreated soil (control). Soil suction was significantly (P < 0.05) increased by 58% in soils amended with 3% and 5% GGBS. Compared to the control, soil amended with 3% and 5% GGBS has exhibited higher air-entry value (AEV) and higher water retention ability. The study revealed that addition of GGBS increased soil water availability for plant growth. This implies that to achieve statistically significant improvement in P. ternata growth and soil hydrological responses 3% GGBS should be applied in Cd-contaminated soil. Key words: soil contamination, cadmium, plant growth, medicinal plant, soil suction. Pinellia ternata est une plante medicinale souvent contaminee par le cadmium (Cd), qui inhibe sa croissance et son metabolisme. Dans cette etude, le laitier de haut fourneau granule et broye (<< GGBS >>) est propose comme amendement du sol pour reduire la disponibilite du Cd aux plantes et donc augmenter la succion induite par la transpiration. On a preleve dans le Guizhou, en Chine, du sol de terrain (sable graveleux limoneux) contamine par 1,5 mg * [kg.sup.-1] de Cd. La croissance de P. ternata dans des sols amendes avec 0,3 et 5% de GGBS a ete etudiee dans une chambre a temperature et humidite controlees. Les sols amendes avec 3 et 5 % de GGBS ont augmente significativement (P < 0,05) l'indice de surface foliaire (<< LAI >>) de 29 et 30 %, l'indice de surface radiculaire (<< RAI>>) de 65 et 66 %, respectivement, comparativement aux sols non traites (temoins). La succion du sol a augmente de facon significative (P < 0,05) de 58 % dans les sols amendes avec 3 et 5 % de GGBS. Comparativement aux temoins, les sols amendes avec 3 et 5 % de GGBS ont montre une valeur d'entree d'air (VEA) plus elevee et une meilleure capacite de retention d'eau. L'etude a revele que l'ajout de GGBS augmentait la disponibilite de l'eau du sol pour la croissance des plantes. Cela signifie que pour obtenir une amelioration statistiquement significative de la croissance de P. ternata et des reponses hydrologiques du sol, il faut appliquer 3 % de GGBS dans les sols contamines par le Cd. [Traduit par la Redaction] Mots-cles: contamination des sols, cadmium, croissance des plantes, plantes medicinales, succion du sol., Introduction Plant growth performance is affected by many abiotic and biotic factors, in particular the presence of environmental stresses such as heavy metals. The effects of heavy metals on the [...]

Published
2020
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81. Spatial constraints underlying the retinal mosaics of two types of horizontal cells in cat and macaque

Author

Eglen, Stephen J. and Wong, James C. T.

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

Most types of retinal neurons are spatially positioned in non-random patterns, termed retinal mosaics. Several developmental mechanisms are thought to be important in the formation of these mosaics. Most evidence to date suggests that homotypic constraints within a type of neuron are dominant, and that heterotypic interactions between different types of neuron are rare. In an analysis of macaque H1 and H2 horizontal cell mosaics, W\"assle et al. (2000) suggested that the high regularity index of the combined H1 and H2 mosaic might be caused by heterotypic interactions during development. Here we use computer modelling to suggest that the high regularity index of the combined H1 and H2 mosaic is a by-product of the basic constraint that two neurons cannot occupy the same space. The spatial arrangement of type A and type B horizontal cells in cat retina also follow this same principle.

Published
2012
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84. Roles of small RNAs in soybean defense against Phytophthora sojae infection

Author

Wong, James, Gao, Lei, Yang, Yang, Zhai, Jixian, Arikit, Siwaret, Yu, Yu, Duan, Shuyi, Chan, Vicky, Xiong, Qin, Yan, Jun, Li, Shengben, Liu, Renyi, Wang, Yuanchao, Tang, Guiliang, Meyers, Blake C, Chen, Xuemei, and Ma, Wenbo

Subjects
Plant Biology, Biological Sciences, Biotechnology, Genetics, 2.1 Biological and endogenous factors, Aetiology, Infection, Disease Resistance, Gene Expression Regulation, Plant, Genes, Reporter, Host-Parasite Interactions, Isoflavones, MicroRNAs, Phytophthora, Plant Diseases, Plant Roots, RNA, Plant, RNA, Small Interfering, Soybeans, Glycine max, Phytophthora sojae, oomycetes, microRNAs, phasiRNAs, defense gene regulation, Defense gene regulation, Oomycetes, PhasiRNAs, Biochemistry and Cell Biology, Plant Biology & Botany, Biochemistry and cell biology, Plant biology
Abstract

The genus Phytophthora consists of many notorious pathogens of crops and forestry trees. At present, battling Phytophthora diseases is challenging due to a lack of understanding of their pathogenesis. We investigated the role of small RNAs in regulating soybean defense in response to infection by Phytophthora sojae, the second most destructive pathogen of soybean. Small RNAs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs), are universal regulators that repress target gene expression in eukaryotes. We identified known and novel small RNAs that differentially accumulated during P. sojae infection in soybean roots. Among them, miR393 and miR166 were induced by heat-inactivated P. sojae hyphae, indicating that they may be involved in soybean basal defense. Indeed, knocking down the level of mature miR393 led to enhanced susceptibility of soybean to P. sojae; furthermore, the expression of isoflavonoid biosynthetic genes was drastically reduced in miR393 knockdown roots. These data suggest that miR393 promotes soybean defense against P. sojae. In addition to miRNAs, P. sojae infection also resulted in increased accumulation of phased siRNAs (phasiRNAs) that are predominantly generated from canonical resistance genes encoding nucleotide binding-leucine rich repeat proteins and genes encoding pentatricopeptide repeat-containing proteins. This work identifies specific miRNAs and phasiRNAs that regulate defense-associated genes in soybean during Phytophthora infection.

Published
2014

86. 48-hour Induction of Transdermal Buprenorphine to Extended-release Buprenorphine

Author

Azar, Pouya, primary, Wong, James S.H., additional, Mathew, Nickie, additional, Ignaszewski, Martha J., additional, Partovi, Nilufar, additional, Krausz, Reinhard M., additional, Ajidahun, Adedayo, additional, Thotakura, Sahithi, additional, Harris, Marianne, additional, Barrios, Rolando, additional, Montaner, Julio S.G., additional, and Maharaj, Anil R., additional

Published
2023
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87. Utility of a simplified [18F] sodium fluoride PET imaging method to quantify bone metabolic flux for a wide range of clinical applications

Author

Puri, Tanuj, primary, Frost, Michelle L., additional, Moore, Amelia E. B., additional, Choudhury, Ananya, additional, Vinjamuri, Sobhan, additional, Mahajan, Abhishek, additional, Fynbo, Claire, additional, Vrist, Marie, additional, Theil, Jørn, additional, Kairemo, Kalevi, additional, Wong, James, additional, Zaidi, Habib, additional, Revheim, Mona-Elisabeth, additional, Werner, Thomas J., additional, Alavi, Abass, additional, Cook, Gary J. R., additional, and Blake, Glen M., additional

Published
2023
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91. Bad pot luck.

Author

Wong, James

Subjects
*POTTED plants, *GARDENERS, *GARDENING, *PHYSICS, *GARDENS
Abstract

The article in New Scientist titled "Bad pot luck" by James Wong debunks the myth that starting with potted plants is easier for beginner gardeners. Wong explains that growing plants in pots can lead to failure due to factors like water retention, temperature fluctuations, root restriction, and nutrient deficiencies. He suggests that growing plants in the ground requires fewer inputs and provides a more stable environment for plant growth. Wong, a botanist and science writer, emphasizes the benefits of growing plants in open ground over pots for successful gardening. [Extracted from the article]

Published
2024
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93. Green visions and democratic constraints : the possibility and design of democratic institutions for environmental decision-making

Author

Wong, James Ka-lei

Subjects
363.7, HT Communities. Classes. Races
Abstract

This thesis addresses a recurrent question of our time – whether democracy can secure environmental sustainability – by drawing on literatures in the normative theory of democracy, social choice theory and environmental politics. I propose a basic, yet substantial organising principle, the ‘dilemma of green democracy’, which maps out the possibility of realising green outcomes under democratic constraints. Interdisciplinary ideas from neighbouring disciplines are also imported for the purpose of studying the design of good environmental-democratic institutions. The analytical framework is an integrated one, comprising formal choice theory and normative democratic theory. The first part of the thesis focuses on the possibility of environmentaldemocratic institutions. Chapter 1 introduces the dilemma of green democracy – a conflict between three plausible desiderata for environmental democracy – and suggests several proposals for avoiding the dilemma. It concludes that, as long as the dilemma is resolved, it is logically possible to construct environmental-democratic institutions. Chapters 2, 3 and 4 assess the desirability of the different proposals in terms of procedure and outcome. The general conclusion is that whether these proposals are desirable depends on a number of conditions and/or contextual factors. The second part of the thesis examines the substantive issues in designing environmental-democratic institutions. Chapter 5 discusses how the discursive dilemma in social choice theory and the normative ends of deliberation constrain the inputs of such institutions. Chapter 6 demonstrates how the concept of distributed cognition, drawn from cognitive/computer science, reconciles the tension between technocracy and democracy. Chapter 7 suggests how the theory of cognitive dissonance, drawn from psychology, challenges the epistemic performance of practicable (environmental-) deliberative-democratic institutions. The overall conclusion is two-fold. First, democracy can, at least in principle, secure environmental sustainability, provided that the dilemma of green democracy is resolved. Second, interdisciplinary ideas are useful for designing good democratic institutions for collective environmental decision-making. This conclusion has implications not only for intellectual enquiry, but also for institutional design in practice.

Published
2012

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