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ABAFj hybrid mice were infected intraperitoneally with 10 LD50 of the MengoM strain which had been passaged serially in mouse brain. They developed an acute panencephalomyelitis and leptomeningitis and pancreatitis, resembling infections with other highly neurotropic strains of closely related enteroviruses. Myotropic properties of the Mengo virus used were completely lacking. Histological examination of the spleen revealed (a) a striking activation of reticular cells, pointing to the possible site of previously virologically detected virus multiplication, and (b) the appearance of germinal centers about 2-3 days after infection, indicating the onset of a humoral immune reaction.

Eine Therapie der Amyloidosen erscheint theoretisch durch Beeinflussung amyloidogener Faktoren, Hemmung der Amyloidsynthese, Verhinderung der extracellularen fibrillaren Pracipitation oder der Auflosung bereits abgelagerten Amyloids moglich. Experimentell wurde bisher der Einflus von Medikamenten (vor allem Glykocorticoiden, Chemotherapeutica und Antibiotica), physikalischen (Rontgenbestrahlung) und chirurgischen Masnahmen (Thymektomie, Splenektomie) untersucht. Potentiell wirksam sind Verbindungen bzw. Eingriffe mit transskriptionshemmendem oder RES-stimulierendem Effekt. Korrelationen zu ihrer immunsuppressiven oder -steigernden Wirkung ergeben sich nicht. Eine therapeutisch verwertbare induzierte Lyse von Amyloidfibrillen ist nach den derzeitigen Erfahrungen nicht moglich, obwohl an ihrer Resorbierbarkeit kein Zweifel besteht.

Summary Spontaneous amyloid diagnosed by means of Congo red and polarization microscopy in 3 flamingos, 1 crowned crane, 1 red-breasted goose, and 1 common golden-eye was studied using immunohistochemical techniques. The avian amyloid cross-reacted with a number of monoclonal and polyclonal anti-AA antibodies directed against mammalian amyloid fibril proteins. This confirmed that both "secondary" and "idiopathic" avian amyloid is of the AA-type. The results demonstrate the possibility to successfully using cross-reactive anti-AA antibodies for the diganosis of non-mammalian amyloidosis.