539 results on '"Winston B"'
Search Results
52. Effect of Precursors on the Synthesis of CuO Nanoparticles Under Microwave for Photocatalytic Activity Towards Methylene Blue and Rhodamine B Dyes
- Author
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N. S. Sanjini, Sivan Velmathi, and Winston B
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Aqueous solution ,Materials science ,Biomedical Engineering ,Nanoparticle ,chemistry.chemical_element ,Bioengineering ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Photochemistry ,01 natural sciences ,Copper ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Rhodamine B ,Photocatalysis ,General Materials Science ,Copper chloride ,Fourier transform infrared spectroscopy ,0210 nano-technology ,Methylene blue - Abstract
Copper oxide nanoparticles have been successfully synthesized by microwave assisted precipitation method. Different precursors like copper chloride, copper nitrate and copper sulphate were used for synthesis of CuO nanoparticles with different shape, size and catalytic activity. Sodium hydroxide acts as a capping agent and ethanol as solvent for the synthesis. The XRD study was conducted to confirm the single phase monoclinic structure of as-synthesized and annealed CuO nano particles. The morphology of the as-synthesized and annealed CuO samples was analyzed by high resolution field emission scanning electron microscope. Fourier transform infrared spectroscopy was done for all the synthesized CuO nanoparticles for functional group characterization. The wide band gap and photocatalytic activity were studied by UV-Visible spectroscopy. The photocatalytic degradation of Methylene blue (MB) and Rhodamine B (RhB) dyes in aqueous solution were investigated under UV light (254 nm). In all the cases annealed samples showed good catalytic activity compared to as-synthesized CuO nanoparticles. The CuO nanoparticles from CuCl2 precursor act as excellent photocatalyst for both MB and RhB compared to CuNO₃ and CuSO₄.
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- 2018
53. Students' Level of Awareness and Practice of the University Core Values
- Author
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Vergie S. Otig and Winston B. Gallinero
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Core (game theory) ,Medical education ,Moderate level ,Information Dissemination ,Validity ,Descriptive research ,Psychology - Abstract
This study determined the level of awareness and extent of practice of Liceo de Cagayan University core values among selected college students. Descriptive research design was employed using a researcher-made survey questionnaire that was pilot tested for validity and reliability. The study had 390 respondents, 123 of them were males while 267 were females and most of them belonged to second-year level with the least number of first years. Results revealed that generally, the respondents have moderate level of awareness and moderate level practice of the University core values. The study further underscored that the students’ level of awareness significantly differed with the extent of their practice of the core values. The study suggests the need not only for proper information dissemination of the core values but more importantly for consistent integration of these values in all aspect of teaching-learning situations whether in the classroom or in outside the classroom activities to enhance the awareness and practice of the University core values. Keywords : Awareness, Practice, Core Values
- Published
- 2018
54. Assessment of catch composition and economic analysis of monofilament and multifilament under-meshed gears (Ngongongo) at Likoma Island, Lake Malawi
- Author
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Winston B, Richard, primary, Bandulo Phiri, Titus, additional, and Singini, Wales, additional
- Published
- 2019
- Full Text
- View/download PDF
55. How to Program an ICD to Minimize Inappropriate Shocks
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Paul J. Wang and Winston B. Joe
- Subjects
medicine.medical_specialty ,Inappropriate shock ,business.industry ,Internal medicine ,medicine.medical_treatment ,medicine ,Cardiology ,Catheter ablation ,Duration (project management) ,Implantable cardioverter-defibrillator ,business - Published
- 2017
56. Reverse syphilis screening algorithm fails to demonstrate cost effectiveness in persons living with HIV
- Author
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Winston B. Joe, Christina A. Muzny, Meredith L. Kilgore, and Ellen F. Eaton
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0301 basic medicine ,medicine.medical_specialty ,Cost effectiveness ,Cost-Benefit Analysis ,030106 microbiology ,Human immunodeficiency virus (HIV) ,HIV Infections ,Dermatology ,Screening algorithm ,medicine.disease_cause ,Article ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Mass Screening ,Pharmacology (medical) ,030212 general & internal medicine ,Syphilis ,Intensive care medicine ,health care economics and organizations ,business.industry ,Decision Trees ,Public Health, Environmental and Occupational Health ,medicine.disease ,Cost savings ,Surgery ,Infectious Diseases ,Alabama ,business ,Algorithms ,Healthcare system - Abstract
Although the reverse syphilis screening algorithm is more efficient than the traditional algorithm, it may lead to exorbitant costs for health systems serving persons living with HIV needing annual syphilis screening. Alternatively, the traditional screening algorithm is cost saving in many scenarios.
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- 2017
57. Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease
- Author
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Sandborn, Wj, Feagan, Bg, Rutgeerts, P, Hanauer, S, Colombel, Jf, Sands, Be, Lukas, M, Fedorak, Rn, Lee, S, Bressler, B, Fox, I, Rosario, M, Sankoh, S, Xu, J, Stephens, K, Milch, C, Parikh, A, Bampton P, GEMINI 2 Study G. r. o. u. p., Borody, T, Chung, A, Debinski, H, Florin, T, Hetzel, D, Jakobovits, S, Lawrance, I, Leong, R, Macrae, F, Mitchell, B, Moore, G, Pavli, P, Samuel, D, Weltman, M, Haas, T, Reinisch, W, Vogel, W, Baert, F, De Maeyer, M, De Vos, M, Dewit, O, D'Haens, G, Louis, E, Muls, V, Van Assche, G, Krastev, Z, Nikolovska, D, Petrov, P, Petrov, A, Stoinov, S, Tchernev, K, Vasileva, G, Aumais, G, Axler, J, Bailey, R, Bernstein, C, Bitton, A, Bourdages, R, Cohen, A, Devroede, G, Dhalla, S, Feagan, B, Fedorak, R, Green, D, Greenberg, G, Jones, J, Larkai, E, Macintosh, D, Panaccione, R, Ponich, T, Singh, R, Sy, R, Wiesinger, H, Albin, A, Douda, L, Horny, I, Stehlik, J, Stuksa, J, Volfova, M, Vyhnalek, P, Zadorova, Z, Andersen, V, Bendtsen, F, Fallingborg, J, Rannem, T, Maelt, A, Margus, B, Salupere, R, Allez, M, Des Varennes SB, Desreumaux, P, Dupas, Jl, Grimaud, Jc, Hebuterne, X, Lerebours, E, Picon, L, Zerbib, F, Aldinger, V, Baumgart, D, Buening, C, Dollinger, M, Hoffmann, P, Howaldt, S, Klaus, J, Konturek, Jw, Krummenerl, T, Malfertheiner, P, Schmidt, W, Schreiber, S, Seidler, U, Stallmach, A, Stremmel, W, Zeitz, M, Mantzaris, G, Triantafyllou, K, Ng, C, Bene, L, Fazekas, I, Fejes, R, Gall, J, Horvat, G, Hunyady, B, Salamon, A, Toth, T, Tulassay, Z, Varga, E, Varga, M, Varga Szabo, L, Vincze, A, Oddsson, E, Örvar, K, Ahuja, V, Amarapurkar, D, Chandra, A, Koshy, A, Krishna, P, Ramakrishna, K, Reddy, N, Thorat, V, Patchett, S, Ryan, B, Ben Horin, S, Fishman, S, Lavy, A, Rachmilewitz, D, Ardizzone, S, Corazziari, E, Danese, S, Fries, Walter, Gasbarrini, A, Kohn, A, Sturniolo, Gc, Danilans, A, George, Am, Hilmi, In, Engels, Lg, Ponsioen, Cy, van der Woude CJ, Gearry, R, Haines, M, Schultz, M, Wallace, I, Wyeth, J, Florholmen, J, Jahnsen, J, Lygren, I, Röseth, A, Ciecko Michalska, I, Gonciarz, M, Horynski, M, Huk, J, Jamrozik Kruk, Z, Janke, A, Klupinska, G, Marecik, J, Paradowski, L, Rudzinski, J, Rydzewska, G, Han, Ds, Hong, Sp, Kim, Hj, Kim, Js, Kim, Ko, Kim, Yh, Yang, Sk, Gheorghe, Ls, Voiosu, Rm, Alexeeva, O, Baranovsky, A, Bunkova, E, Burnevich, E, Dolgikh, O, Grinevich, V, Lakhin, A, Tarabar, D, Ling, Kl, Bunganic, I, Cernok, S, Gregus, M, Coetzer, T, Grundling, H, Moola, Sa, Wright, Jp, Ziady, C, Bermejo, F, Calvet, X, Herrerias, Jm, Perez Calle JL, Perez Gisbert, J, Hertervig, E, Karlen, P, Michetti, P, Rogler, G, Seibold, F, Wu, Dc, Atug, O, Kurdas, Oo, Datsenko, O, Dorofyeyev, A, Dudar, L, Golovchenko, O, Klyarits'Ka, I, Skrypnyk, I, Hawthorne, Ab, Middleton, S, Abreu, M, Bala, N, Becker, S, Behm, B, Braun, R, Bukhari, M, Chen, S, Coates, A, Dar, S, Dassopoulos, T, De Villiers, W, Desautels, S, Desta, T, Dimitroff, J, Dryden, G, Duvall, A, Farraye, F, Fein, S, Liu, Bf, Gatof, D, Geenen, D, Ginsburg, P, Glombicki, A, Glover, S, Gordon, G, Grisolano, S, Hanson, J, Hardi, R, Hoffman, B, Isaacs, K, Kim, C, Koval, G, Lashner, B, Lawitz, E, Leman, B, Levine, J, Loftus, E, Mahadevan, U, Mannon, P, Marcet, J, Matsuyama, R, Matusow, G, Mccabe, R, Mirkin, K, Murphy, M, Mushahwar, A, Mutlu, E, Nagrani, M, Nguyen, D, Nichols, M, Nieves Ramirez, A, Oubre, B, Pace, S, Pandak, W, Perera, L, Quadri, A, Quallich, L, Rajapakse, R, Randall, C, Regueiro, M, Safdi, A, Sandborn, W, Sands, B, Saubermann, L, Scherl, E, Schwartz, D, Sedghi, S, Shafran, I, Shepard, R, Siegel, C, Stein, L, Tatum, H, Triebling, A, Vasudeva, R, Winston, B, Wolf, D, Younes, Z, Jewell, D, Mahon, J, Rothstein, R, Snydman, D, Massaro, J, Clifford, D, Berger, J, Major, E, Provenzale, J, Lev, M., GEMINI 2 Study Group, Bampton, P., Borody, T., Chung, A., Debinski, H., Florin, T., Hetzel, D., Jakobovits, S., Lawrance, I., Leong, R., Macrae, F., Mitchell, B., Moore, G., Pavli, P., Samuel, D., Weltman, M., Haas, T., Reinisch, W., Vogel, W., Baert, F., De Maeyer, M., De Vos, M., Dewit, O., D'Haens, G., Louis, E., Muls, V., Van Assche, G., Krastev, Z., Nikolovska, D., Petrov, P., Petrov, A., Stoinov, S., Tchernev, K., Vasileva, G., Aumais, G., Axler, J., Bailey, R., Bernstein, C., Bitton, A., Bourdages, R., Bressler, B., Cohen, A., Devroede, G., Dhalla, S., Feagan, B., Fedorak, R., Green, D., Greenberg, G., Jones, J., Larkai, E., MacIntosh, D., Panaccione, R., Ponich, T., Singh, R., Sy, R., Wiesinger, H., Albin, A., Douda, L., Horny, I., Lukas, M., Stehlik, J., Stuksa, J., Volfova, M., Vyhnalek, P., Zadorova, Z., Andersen, V., Bendtsen, F., Fallingborg, J., Rannem, T., Maelt, A., Margus, B., Salupere, R., Allez, M., Des Varennes SB., Desreumaux, P., Dupas, JL., Grimaud, JC., Hebuterne, X., Lerebours, E., Picon, L., Zerbib, F., Aldinger, V., Baumgart, D., Buening, C., Dollinger, M., Hoffmann, P., Howaldt, S., Klaus, J., Konturek, JW., Krummenerl, T., Malfertheiner, P., Schmidt, W., Schreiber, S., Seidler, U., Stallmach, A., Stremmel, W., Zeitz, M., Mantzaris, G., Triantafyllou, K., Ng, C., Bene, L., Fazekas, I., Fejes, R., Gall, J., Horvat, G., Hunyady, B., Salamon, A., Toth, T., Tulassay, Z., Varga, E., Varga, M., Varga-Szabo, L., Vincze, A., Oddsson, E., Örvar, K., Ahuja, V., Amarapurkar, D., Chandra, A., Koshy, A., Krishna, P., Ramakrishna, K., Reddy, N., Thorat, V., Patchett, S., Ryan, B., Ben Horin, S., Fishman, S., Lavy, A., Rachmilewitz, D., Ardizzone, S., Corazziari, E., Danese, S., Fries, W., Gasbarrini, A., Kohn, A., Sturniolo, GC., Danilans, A., George, AM., Hilmi, IN., Engels, LG., Ponsioen, CY., van der Woude CJ., Gearry, R., Haines, M., Schultz, M., Wallace, I., Wyeth, J., Florholmen, J., Jahnsen, J., Lygren, I., Röseth, A., Ciecko-Michalska, I., Gonciarz, M., Horynski, M., Huk, J., Jamrozik-Kruk, Z., Janke, A., Klupinska, G., Marecik, J., Paradowski, L., Rudzinski, J., Rydzewska, G., Han, DS., Hong, SP., Kim, HJ., Kim, JS., Kim, KO., Kim, YH., Yang, SK., Gheorghe, LS., Voiosu, RM., Alexeeva, O., Baranovsky, A., Bunkova, E., Burnevich, E., Dolgikh, O., Grinevich, V., Lakhin, A., Tarabar, D., Ling, KL., Bunganic, I., Cernok, S., Gregus, M., Coetzer, T., Grundling, H., Moola, SA., Wright, JP., Ziady, C., Bermejo, F., Calvet, X., Herrerias, JM., Perez Calle JL., Perez Gisbert, J., Hertervig, E., Karlen, P., Michetti, P., Rogler, G., Seibold, F., Wu, DC., Atug, O., Kurdas, OO., Datsenko, O., Dorofyeyev, A., Dudar, L., Golovchenko, O., Klyarits'ka, I., Skrypnyk, I., Hawthorne, AB., Middleton, S., Abreu, M., Bala, N., Becker, S., Behm, B., Braun, R., Bukhari, M., Chen, S., Coates, A., Dar, S., Dassopoulos, T., De Villiers, W., Desautels, S., Desta, T., Dimitroff, J., Dryden, G., Duvall, A., Farraye, F., Fein, S., Liu, BF., Gatof, D., Geenen, D., Ginsburg, P., Glombicki, A., Glover, S., Gordon, G., Grisolano, S., Hanauer, S., Hanson, J., Hardi, R., Hoffman, B., Isaacs, K., Kim, C., Koval, G., Lashner, B., Lawitz, E., Lee, S., Leman, B., Levine, J., Loftus, E., Mahadevan, U., Mannon, P., Marcet, J., Matsuyama, R., Matusow, G., McCabe, R., Mirkin, K., Murphy, M., Mushahwar, A., Mutlu, E., Nagrani, M., Nguyen, D., Nichols, M., Nieves Ramirez, A., Oubre, B., Pace, S., Pandak, W., Perera, L., Quadri, A., Quallich, L., Rajapakse, R., Randall, C., Regueiro, M., Safdi, A., Sandborn, W., Sands, B., Saubermann, L., Scherl, E., Schwartz, D., Sedghi, S., Shafran, I., Shepard, R., Siegel, C., Stein, L., Tatum, H., Triebling, A., Vasudeva, R., Winston, B., Wolf, D., Younes, Z., Feagan, BG., Colombel, JF., Rutgeerts, P., Sandborn, WJ., Sands, BE., Jewell, D., Mahon, J., Rothstein, R., Snydman, D., Massaro, J., Clifford, D., Berger, J., Major, E., Provenzale, J., Lev, M., and Medical Microbiology & Infectious Diseases
- Subjects
Adult ,Male ,Integrins ,medicine.medical_specialty ,HUMAN POLYOMAVIRUSES ,JC ,Antibodies/blood ,Antibodies, Monoclonal, Humanized/adverse effects ,Antibodies, Monoclonal, Humanized/immunology ,Crohn Disease/drug therapy ,Double-Blind Method ,Drug Administration Schedule ,Drug Therapy, Combination ,Female ,Glucocorticoids/therapeutic use ,Humans ,Immunosuppressive Agents/therapeutic use ,Induction Chemotherapy ,Infusions, Intravenous/adverse effects ,Integrins/antagonists & inhibitors ,Integrins/immunology ,Maintenance Chemotherapy ,Middle Aged ,PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY ,Antibodies, Monoclonal, Humanized ,Placebo ,Gastroenterology ,Inflammatory bowel disease ,Antibodies ,Vedolizumab ,CERTOLIZUMAB PEGOL ,Natalizumab ,Crohn Disease ,Maintenance therapy ,HUMANIZED ANTIBODY ,Internal medicine ,Ustekinumab ,medicine ,Certolizumab pegol ,Infusions, Intravenous ,Glucocorticoids ,NATALIZUMAB ,business.industry ,Induction chemotherapy ,General Medicine ,medicine.disease ,PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY, RELAPSING MULTIPLE-SCLEROSIS, INFLAMMATORY-BOWEL-DISEASE, HUMAN POLYOMAVIRUSES, HUMANIZED ANTIBODY, CERTOLIZUMAB PEGOL, ULCERATIVE-COLITIS, RANDOMIZED-TRIAL, NATALIZUMAB, JC ,RANDOMIZED-TRIAL ,digestive system diseases ,Surgery ,ULCERATIVE-COLITIS ,RELAPSING MULTIPLE-SCLEROSIS ,business ,Immunosuppressive Agents ,INFLAMMATORY-BOWEL-DISEASE ,medicine.drug - Abstract
BACKGROUND: The efficacy of vedolizumab, an α4β7 integrin antibody, in Crohn's disease is unknown. METHODS: In an integrated study with separate induction and maintenance trials, we assessed intravenous vedolizumab therapy (300 mg) in adults with active Crohn's disease. In the induction trial, 368 patients were randomly assigned to receive vedolizumab or placebo at weeks 0 and 2 (cohort 1), and 747 patients received open-label vedolizumab at weeks 0 and 2 (cohort 2); disease status was assessed at week 6. In the maintenance trial, 461 patients who had had a response to vedolizumab were randomly assigned to receive placebo or vedolizumab every 8 or 4 weeks until week 52. RESULTS: At week 6, a total of 14.5% of the patients in cohort 1 who received vedolizumab and 6.8% who received placebo were in clinical remission (i.e., had a score on the Crohn's Disease Activity Index [CDAI] of ≤150, with scores ranging from 0 to approximately 600 and higher scores indicating greater disease activity) (P=0.02); a total of 31.4% and 25.7% of the patients, respectively, had a CDAI-100 response (≥100-point decrease in the CDAI score) (P=0.23). Among patients in cohorts 1 and 2 who had a response to induction therapy, 39.0% and 36.4% of those assigned to vedolizumab every 8 weeks and every 4 weeks, respectively, were in clinical remission at week 52, as compared with 21.6% assigned to placebo (P
- Published
- 2013
58. Synthesis, Characterization and Application of Cobalt Incorporated Mesoporous KIT-6 for the Visible Light Assisted Degradation of Methylene Blue
- Author
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Sivan Velmathi, N. S. Sanjini, and Winston B
- Subjects
Materials science ,Diffuse reflectance infrared fourier transform ,Scanning electron microscope ,Biomedical Engineering ,chemistry.chemical_element ,Bioengineering ,General Chemistry ,Condensed Matter Physics ,Photochemistry ,chemistry.chemical_compound ,chemistry ,Photocatalysis ,General Materials Science ,Spectroscopy ,Mesoporous material ,Cobalt ,Methylene blue ,Nuclear chemistry ,Visible spectrum - Abstract
Highly ordered mesoporous three dimensional la3d cobalt doped KIT-6 (Co-KIT-6) material was synthesized by the simple impregnation method and characterized by various physicochemical techniques such as X-ray diffraction, N2 adsorption-desorption isotherm, diffuse reflectance spectroscopy, Fourier transform infra-red spectroscopy and scanning electron microscopy. Larger pore diameter tuned with a narrow size distribution was observed for prepared Co-KIT-6. A series of Co-KIT-6 with different weight percentages solutions were prepared and the photocatalytic efficacy of the samples for degradation of methylene blue was studied under UV and visible light using UV-visible spectrophotometer. It was found that the catalytic activity depends on the amount of cobalt incorporated into the material. The complete degradation of dye was observed within 50 min. Different amount of catalyst and reaction time was considered for the optimization studies.
- Published
- 2015
59. Band Gap Tuning of h-MoO3 Nanocrystals for Efficient Visible Light Photocatalytic Activity Against Methylene Blue Dye
- Author
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Arumugam Chandra Bose, Sivan Velmathi, A. Chithambararaj, Winston B, and N. S. Sanjini
- Subjects
Photoluminescence ,Materials science ,Diffuse reflectance infrared fourier transform ,Scanning electron microscope ,Infrared ,Biomedical Engineering ,Analytical chemistry ,Bioengineering ,General Chemistry ,Condensed Matter Physics ,Crystal ,Photocatalysis ,General Materials Science ,Crystallite ,Spectroscopy - Abstract
The photocatalytic degradation of methylene blue (MB) dye in aqueous solution was investigated using hexagonal molybdenum oxide (h-MoO3) nanocrystals under visible light irradiation. Chemical precipitation method was utilized to synthesize h-MoO3 and control over the crystal size, shape and distribution were characterized by using HNO3 and HCl as precipitating reagents. The photocatalysts were examined through X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray spectrum (EDX) for structural, functional, surface morphology and elemental analysis, respectively. The XRD results revealed that the samples were in single phase hexagonal crystal structure. XRD peak broadening analysis was used for crystallite size and strain estimation. The particles were anisotropic in nature and showed one dimensional (1-D) rod structure with hexagonal cross section. Further, the crystal phase stability, optical absorption and emission properties were studied by thermo gravimetric analysis (TGA), diffuse reflectance spectroscopy (DRS) and photoluminescence (PL) measurements, respectively. The photocatalytic results demonstrated that the photocatalytic activity of h-MoO3 synthesized using HCl was improved, in comparison to that of HNO3 utilized h-MoO3 sample.
- Published
- 2015
60. Evidence-based training for legal interpreters to work with deaf jurors
- Author
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Winston, B, Monikowski, C, Lee, RG, Napier, J, Russell, D, Hale, S, Spencer, D, San Roque, M, Winston, B, Monikowski, C, Lee, RG, Napier, J, Russell, D, Hale, S, Spencer, D, and San Roque, M
- Abstract
At present the United States is the only country in the world that systematically allows deaf sign language users to perform their civic duty as jurors, but little is known about how interpreters work in this setting. This paper provides an overview of key findings of studies that have explored ethnographic observations of an interpreted jury empanelment process in the US (Napier & Russell, in preparation-a), interviews with court judges and deaf people that have served on juries in the US (Hale et al, 2017; Napier & Russell, in preparation-b; Spencer et al, 2017), examination of deaf juror participation in jury deliberations in a mock-trial (Hale et al, 2017; Napier, et al, in preparation); and discussions with key legal and deaf community stakeholders in evaluating whether deaf people should be able to serve as jurors (Napier, et al, in press). These interdisciplinary studies conducted by signed and spoken language interpreter researchers with law academics, also pave the way for interdisciplinary curriculum development. Recommendations are made for evidence-based best practice in the training of legal interpreters to work with deaf jurors.
- Published
- 2018
61. Elastografia por cisalhamento (shear wave) para placas ateroscleróticas carotídeas extracranianas: princípios técnicos e como realizar
- Author
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Pedro Luciano Mellucci Filho, Matheus Bertanha, Rodrigo Gibin Jaldin, Winston Bonetti Yoshida, and Marcone Lima Sobreira
- Subjects
doenças das artérias carótidas ,estenose das carótidas ,ultrassonografia Doppler ,interpretação de imagem assistida por computador ,técnicas de imagem por elasticidade ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Resumo Na esteira de estudos direcionados à placa aterosclerótica e em busca de variáveis quantificáveis que adicionem informações à tomada de decisão terapêutica, a avaliação a partir de elastografia shear wave (SWE) se apresenta como alternativa reprodutível e promissora. Utilizamos um único aparelho Logiq S8 (General Electric, Boston, Massachusetts, Estados Unidos) com um transdutor linear multifrequencial 8,5-11 MHz em 10 MHz em corte longitudinal. Consideramos critérios relevantes para a aquisição de imagem: adequada insonação longitudinal, diferenciação do complexo médio-intimal, delineamento de túnicas adventícias proximal e distal, lúmen vascular, boa visualização da placa aterosclerótica, ciclo em diástole ventricular e ausência de alterações incongruentes. A SWE é um método emergente e extremamente promissor no contexto da avaliação de placas carotídeas, podendo contribuir no futuro para a tomada de decisão terapêutica baseada em características relativas à placa aterosclerótica de forma reprodutível entre aparelhos e examinadores.
- Published
- 2023
- Full Text
- View/download PDF
62. Extent of Dissemination, Awareness, and Acceptability of the Revised LDCU Vision, Mission, and CAS Objectives among Students and Faculty
- Author
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Winston B. Gallinero and Vergie S. Otig
- Subjects
Medical education ,Significant difference ,Pedagogy ,Moderate level ,Descriptive research ,Psychology ,Dissemination - Abstract
This study determined the extent of dissemination of information, awareness, and degree of acceptability of the revised LDCU vision and mission and the CAS objectives among students and faculty. Descriptive research design was employed using a researcher-made survey questionnaire. Results show a moderate level of the extent of dissemination and awareness of the revised LDCU vision and mission and CAS objectives to both faculty and student-respondents. The finding suggests that information was disseminated properly and clearly through brochures, bulletin boards, leaflets, manuals, posters, and meetings. In terms of degree of acceptability, the results reveal that both faculty and student-respondents accept the vision and mission and CAS objectives for “total human formation†and delivery of “quality education.†Meanwhile, both faculty and student-respondents’ profile shows no significant difference in their extent of dissemination and awareness and with their degree of acceptance of the revised LDCU vision and mission and CAS objectives. It can be implied that they come to accept the vision and mission regardless of their profile. Lastly, both faculty and students’ extent of dissemination and degree of acceptability was found to have a significant difference. It can be deduced that if the information was disseminated clearly through different sources such as posters, bulletin boards, and the like the more they become aware by accepting the revised University’s vision and mission and CAS objectives.  Keywords: Dissemination, awareness, acceptability, revised LDCU vision and mission, CAS objectives
- Published
- 2017
63. Arrhythmias in Special Populations
- Author
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Winston B. Joe and Paul J. Wang
- Subjects
medicine.medical_specialty ,Pregnancy ,Special populations ,business.industry ,medicine.medical_treatment ,Stressor ,Catheter ablation ,medicine.disease ,Sudden death ,Cardiovascular physiology ,Cardiac surgery ,cardiovascular system ,medicine ,Intensive care medicine ,business ,Pathological - Abstract
The occurrence of cardiac arrhythmias is dependent on the cellular, structural, autonomic, and hormonal environment in which the heart functions. Stressors such as pregnancy, competitive athletics, and surgery serve to modulate this arrhythmogenic environment. The altered cardiac physiology that results from these stressors can lead to new and recurrent arrhythmias. When these occur, they may have significant implications with respect to patient management, morbidity, and mortality. Mitigation of these consequences depends on the understanding and treatment of pathological rhythms, and on an appreciation of issues particular to these unique populations. The following chapter discusses arrhythmias in the groups comprised of patients in competitive athletics, pregnancy, heart transplant, and after major surgery.
- Published
- 2017
64. 03:27 PM Abstract No. 86 Percutaneous cryoablation of stage T1b renal cell carcinoma: safety, technical results, and clinical outcomes
- Author
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E. Keasler, Ahmed Kamel Abdel Aal, Andrew J. Gunn, Soroush Rais-Bahrami, Khalid Mahmoud, A. Salei, Winston B Joe, H. El Khudari, E. Bready, P. Patten, and Jennifer Gordetsky
- Subjects
medicine.medical_specialty ,Percutaneous cryoablation ,Renal cell carcinoma ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,Stage (cooking) ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2019
65. Crime and Punishment on Campus: An Inner City Case
- Author
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Cox, Winston B.
- Abstract
Case studies can help cast light on how schools face the problems of discipline and low achievement, neither of which is created or can be the sole responsibility of the schools. An attempt is made to report on the experience and performance of a public senior high school in the area of discipline. (Author)
- Published
- 1978
66. Safety of cell therapy with mesenchymal stromal cells): An updated systematic review and meta-analysis of randomized controlled trials (SafeCell update)
- Author
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Thomspon, M., primary, Wolfe, D., additional, Champagne, J., additional, Mei, S.H., additional, Lalu, M., additional, Fergusson, D., additional, Winston, B., additional, Marshall, J., additional, Walley, K., additional, English, S., additional, dos Santos, C., additional, Granton, J., additional, Stewart, D.J., additional, and McIntyre, L., additional
- Published
- 2018
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67. Students' Level of Awareness and Practice of the University Core Values
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Gallinero, Winston B., primary and Otig, Vergie S., additional
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- 2018
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68. College Radio Takeovers and Shutdowns: An Analysis of News Coverage from 2006–2016
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Smallwood, Amber M. K., primary, Yates, Bradford L., additional, and Tripp, Winston B., additional
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- 2018
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69. Being green: Patterns of participation in the environmental movement
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Tripp, Winston B, primary
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- 2017
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70. Should dates trump context? Evaluation of the Cave 7 skeletal assemblage radiocarbon dates
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Phil R. Geib and Winston B. Hurst
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Archeology ,geography ,geography.geographical_feature_category ,Context (language use) ,Archaeology ,law.invention ,Archaeological science ,Prehistory ,Cave ,law ,Context evaluation ,Assemblage (archaeology) ,Radiocarbon dating ,Geology ,Chronology - Abstract
“Massacre” was the accepted interpretation for a prehistoric skeletal assemblage of around 90 individuals from Cave 7 in the SE Utah of the North American Southwest since the 1890s. Coltrain and others (Journal of Archaeological Science 39, 2220–2230) rejected this account based on a dispersed suite of AMS radiocarbon dates on purified bone collagen from the interred individuals. Since dates from skeletons exhibiting perimortem damage were scattered across some 400 radiocarbon years, Coltrain et al. argued for multiple interments of victims of violence and related kin spread across several centuries. The temporal placement of interment events in Cave 7 clearly cannot be known independent of radiocarbon assays but such assays should not be privileged above contextual information about which individuals were interred together unless verified by an independent dating laboratory. Only by ignoring important information about burial context in the 1893 field record can the dates of Coltrain et al. be accepted as accurate estimates of time of death. We redated residual collagen from 11 of the Cave 7 individuals because of significant contextual anomalies with some of the prior results. The new assays combined with contextual evidence demonstrate that some of Coltrain et al.’s dates are either too old or too young; the dates are neither sufficiently accurate (true estimates of sample age) nor sufficiently precise (small confidence intervals) to refute a single-event massacre or to confirm multiple interment events in Cave 7. Nonetheless, dates that meet these criteria disclose at least two interment events, a large one of mostly adult males, many exhibiting perimortem damage (a massacre assemblage), and a small one consisting of an adult female with three children. A third interment event of a few adult females and child is possible based primarily on context since the date distribution in this case overlaps substantially with that of the massacre victims; context also hints at other interment events. Aside from chronology we clarify the number of Basketmaker individuals interred at the site and the incidence of perimortem violence. A single-event mass killing continues to be the most likely interpretation for around 58 individuals, mostly adult males (at least 35) but also adult females and children. This incident occurred between cal. AD 20–80 and doubtless had a significant social impact at the time because of its scale, reverberating throughout the early farming communities of the Southwest.
- Published
- 2013
71. Teaching History in an Army College Program
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Thorson, Winston B.
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- 1944
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72. "Regimentation" and Comparable Educational Measurement
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Stephens, Winston B.
- Published
- 1935
73. Tests and Student Guidance
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Stephens, Winston B.
- Published
- 1934
74. Washington State Nominating Conventions
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Thorson, Winston B.
- Published
- 1944
75. Pacific Northwest Opinion on the Russo-Japanese War of 1904-1905
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Thorson, Winston B.
- Published
- 1944
76. Pacific Northwest Opinion on the Washington Conference of 1921-1922
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Thorson, Winston B.
- Published
- 1946
77. Freycinet's Egyptian Policy in 1882
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Thorson, Winston B.
- Published
- 1942
78. The First Experiment in European Collective Security
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Thorson, Winston B.
- Published
- 1948
79. Reappraisal of a Diplomatist
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Thorson, Winston B.
- Published
- 1945
80. The Relationship of Self-Esteem and Self-Efficacy to Student Engagement among Gay and Lesbian Students: A Case Study
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Winston B. Gallinero, Vergie S. Otig, and Maria Gracia Jurial
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Self-efficacy ,Nonprobability sampling ,Scale (social sciences) ,media_common.quotation_subject ,Self-esteem ,Relevance (law) ,Cognition ,Student engagement ,Lesbian ,Psychology ,Social psychology ,Developmental psychology ,media_common - Abstract
This study was conducted to determine the self-esteem, self-efficacy, and student engagement among gay and lesbian students in the University. It is specifically aimed to associate the level of self-esteem and self-efficacy of the respondents with their affective and cognitive engagement. A purposive sampling procedure was used in gathering the data from the 85 respondents. Adapted survey questionnaires by Rosenberg Self-esteem Scale and General Self-efficacy Scale and a modified Student Engagement Instrument were utilized as guide in gathering the necessary information. Results show that the students’ level of self-esteem was high (3.06) and self-efficacy was also high (3.04). The findings suggest that they have a positive attitude about themselves, and they believe they can surpass almost all the challenges that come their way. In terms of engagement, the level of affective engagement was all high in all indicators while in cognitive engagement, relevance of school work was high (3.39), future aspirations and goals revealed as very high (3.68), however, extrinsic motivation was interpreted as moderate in cognitive engagement (2.32). On the other hand, self-esteem and affective and cognitive engagement were not significantly correlated with each other. It can be gleaned that self-esteem has no bearing on how they engage in affective and cognitive aspects. Hence, it was found out that their level of self-efficacy yielded with a 0.410 Pearson-correlation and a p-value of 0.000 which revealed a strong positive relationship which was significantly associated with their affective and cognitive engagement. It can be deduced that their positive beliefs that they can surpass their problems can be strongly associated with how much they engage affectively and cognitively. Keywords: Self-esteem, self-efficacy, affective and cognitive engagement, gays and lesbians
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- 2015
81. Hybrid Verrucous—Squamous Cell Carcinoma of the Ovary With Synchronous Squamous Cell Carcinoma of the Endometrium
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Winston B. Magno, J. Alexander Palesty, Stanley J. Dudrick, Shady H. Macaron, Tiffany T. Fancher, and Munir H. Hamzi
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Oncology ,medicine.medical_specialty ,Pathology ,Uterus ,Ovary ,Endometrium ,Pathology and Forensic Medicine ,Vulva ,Neoplasms, Multiple Primary ,Internal medicine ,Tachycardia, Supraventricular ,medicine ,Carcinoma ,Humans ,Carcinoma, Verrucous ,Diverticulitis ,Aged, 80 and over ,Ovarian Neoplasms ,business.industry ,Verrucous carcinoma ,Aortic Valve Stenosis ,medicine.disease ,Endometrial Neoplasms ,Squamous carcinoma ,medicine.anatomical_structure ,Hypertension ,Carcinoma, Squamous Cell ,Gastroesophageal Reflux ,Vagina ,Female ,Surgery ,Anatomy ,business - Abstract
Verrucous carcinoma, a variant of well-differentiated squamous cell carcinoma, is usually described in the literature as arising in the oral cavity, skin, and larynx. The reports on verrucous carcinoma arising in the genital tract, usually originating in the vagina, vulva, or uterine cervix, are few. Verrucous carcinoma arising in the ovary has not been previously reported. In this article, a unique hybrid carcinoma, a large aggressive verrucous carcinoma in combination with squamous carcinoma of the left ovary and synchronously occurring with a squamous cell carcinoma in the endometrium, is presented. This unique case of a hybrid carcinoma includes the first-known case of this type of carcinoma involving the ovary. The negative cervical evaluation findings, together with the histologic patterns of the tumors in the uterus and the ovary, support the conclusion that these 2 carcinomas are synchronous, one arising in the left ovary and the other arising in the uterus.
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- 2008
82. Extent of Dissemination, Awareness, and Acceptability of the Revised LDCU Vision, Mission, and CAS Objectives among Students and Faculty
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Gallinero, Winston B., primary and Otig, Vergie S., additional
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- 2017
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83. Effect of Precursors on the Synthesis of CuO Nanoparticles Under Microwave for Photocatalytic Activity Towards Methylene Blue and Rhodamine B Dyes
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Sanjini, N. S, primary, Winston, B, additional, and Velmathi, S, additional
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- 2017
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84. Management of End Stage Renal Disease in Persons Living with HIV: A Cost-Effectiveness Analysis
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Joe, Winston B, primary and Eaton, Ellen F, additional
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- 2017
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85. Osteomyelitis of the Calcaneus With Disseminated Multiorgan Involvement
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Rachel Zarchy DPM, Juhi Patel DPM, Ali Rashidi MD, Winston Burke DPM, PharmD, Feinan Shi MD, and Jonathan Martin DO
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Orthopedic surgery ,RD701-811 - Published
- 2023
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86. Pós-processamento da mediana de escala de cinza (GSM), posterização e remapeamento de cores para ultrassonografia de carótidas
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Pedro Luciano Mellucci Filho, Matheus Bertanha, Rodrigo Gibin Jaldin, Winston Bonetti Yoshida, and Marcone Lima Sobreira
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doenças das artérias carótidas ,estenose das carótidas ,ultrassonografia Doppler ,pós-imagem ,interpretação de imagem assistida por computador ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Resumo Fatores relativos à placa aterosclerótica podem indicar instabilidade como ulcerações, hemorragias intraplaca, núcleo lipídico, capa fibrosa delgada ou irregular e inflamação. A mediana de escala de cinza (GSM, de greyscale median) da placa é um dos métodos mais difundidos de estudo da placa aterosclerótica; nesse sentido, é importante criar uma padronização da pós-processamento de forma compreensível. O pós-processamento foi realizado no software Photoshop 23.1.1. A padronização da imagem foi alcançada com o ajuste de curvas do histograma de escalas de cinza definindo o ponto mais escuro do lúmen vascular (sangue) para zero e a adventícia distal para 190. A posterização e o remapeamento de cores foram realizados. Um método que apresenta o atual estado da arte da técnica de forma acessível e ilustrativa pode contribuir para disseminação da análise de GSM. Neste artigo, esse processo é demonstrado passo a passo.
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- 2023
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87. Comparação das alterações angiográficas entre pacientes diabéticos e não diabéticos com doença arterial periférica
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Giovanni Ortale Trainotti, Jamil Victor Mariúba, Matheus Bertanha, Marcone Lima Sobreira, Ricardo de Alvarenga Yoshida, Rodrigo Gibin Jaldin, Paula Angeleli Bueno de Camargo, and Winston Bonetti Yoshida
- Subjects
angiografia digital ,doenças vasculares periféricas ,diabetes ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Resumo Contexto Os diabéticos possuem risco de 5 a 15 vezes maior para o desenvolvimento de doença arterial periférica (DAP), e poucos estudos compararam fatores de risco e a distribuição e gravidade de alterações arteriais angiográficas entre diabéticos e não diabéticos. Objetivos Comparar alterações angiográficas entre pacientes diabéticos e não diabéticos com DAP avançada, correlacionando-as com demais fatores de risco. Métodos Trata-se de um estudo transversal retrospectivo de pacientes consecutivos submetidos a arteriografia de membros inferiores por DAP (Rutherford de 3 a 6), usando os escores angiográficos TASC II e de Bollinger et al. Os critérios de exclusão incluíram arteriografias de membros superiores, exames incompletos ou sem nitidez e cirurgias prévias. A análise estatística incluiu o teste do qui-quadrado ou exato de Fisher para variáveis discretas e o teste t para variáveis contínuas (significância: p < 0,05). Resultados Foram estudados 153 pacientes com idade média de 67 anos, sendo 50,9% do sexo feminino e 58,2% diabéticos. Um total de 91 pacientes (59%) tinha lesão trófica (Rutherford 5 ou 6), enquanto 62 (41%) tinham dor em repouso ou claudicação limitante (Rutherford 3 e 4). Entre os diabéticos, 81,7% eram hipertensos, 29,4% nunca fumaram e 14% tinham antecedente de infarto do miocárdio. Pelo escore de Bollinger et al., as artérias infrapoplíteas foram as mais comprometidas, em especial a tibial anterior (p = 0,005) nos diabéticos, enquanto a femoral superficial foi mais acometida nos não diabéticos (p = 0,008). Pelo TASC II, as alterações arteriográficas mais graves ocorreram no segmento fêmoro-poplíteo nos pacientes não diabéticos (p = 0,019). Conclusões Os setores infrapoplíteos foram os mais comprometidos nos diabéticos, enquanto o setor femoral foi o mais acometido nos não diabéticos.
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- 2023
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88. Community Outreach Programs Calculating Submission: The Behavior of Students when Participating in School
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Winston B. Gallinero and Oliver N. Plaza
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Outreach ,Medical education ,Data collection ,business.industry ,ComputingMilieux_COMPUTERSANDEDUCATION ,Public relations ,Psychology ,Research process ,business ,Grounded theory ,Meaning (linguistics) - Abstract
The paper was an application of classical ‘Barney G. Glaser’s’ grounded theory methodology on participating in community outreach programs. The main aim of the study was to generate theory from data that will explain what is going on when students participate in outreach programs. The study’s objectives included the discovery of (1) the main concern of the participants and (2) their preponderant behavior in trying to resolve this concern. The whole research process was driven by data; meaning it started with data gathering, followed by comparative data analyzes with data collection, until a substantive theory was generated. In-depth and unstructured one-on-one and group interviews and discussions supplemented with documentary analysis were the methods employed to collect data. Altogether, forty-five students who participated in community outreach programs were interviewed. It was discovered that the students main concern was “getting through”- that is how to end, complete, and pass the community outreach program and achieved benefits or “preconceived self-gain” which unconsciously defined their participation in the community outreach program. To get through and achieved preconceived self-gain, students commonly exhibited “calculating submission” behavior where they measure the degree of participation in the outreach program they participated in vis-a-vis preconceived self-gain. Keywords - grounded theory, community outreach program, getting through, preconceived self-gain, calculating submission, behavior of students
- Published
- 2014
89. Binasal Occlusion for the Treatment of Visual Motion Sensitivity after Traumatic Brain Injury: A Case Series.
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Posvar, Winston B., Klein, Steven, Gutierrez, Jill M. Bakota, and Capo-Aponte, Jose
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- *
BIFOCAL lenses , *REHABILITATION of blind people , *DIZZINESS , *EYE examination , *REFRACTIVE errors , *OPTOMETRY , *PHOTOSENSITIVITY disorders , *MILITARY personnel , *VISUAL perception , *REHABILITATION for brain injury patients - Abstract
Background: Symptoms of visual motion sensitivity (VMS) secondary to traumatic brain injury (TBI) have previously been reported to improve with binasal occlusion (BNO). In previous literature, BNO has improved ambulation and gait in those with VMS. The aim of this case series was to demonstrate how BNO improves symptoms of VMS during ambulation in a military population with history of TBI. Methods: Three patients with a history of TBI and suspected VMS underwent a neurooptometric examination, including BNO applied to spectacles during ambulation in a clinical setting. Gait was subjectively evaluated by the examiner, and symptoms of VMS were assessed by the patient. Results: Subjective improvement in gait and symptoms of VMS were appreciated in three TBI patients with VMS. Two subjects also demonstrated improved versional function with BNO. All three subjects were subsequently prescribed BNO and neuro-optometric vision rehabilitation. One subject was lost to follow-up, and two subjects reported improved visual function with BNO several months after its initial application. Conclusion: BNO is an effective tool for treating VMS symptoms secondary to TBI. The effect of neuro-optometric vision rehabilitation in conjunction with BNO for VMS is yet to be determined. [ABSTRACT FROM AUTHOR]
- Published
- 2019
90. PAciFy Cough—a multicentre, double-blind, placebo-controlled, crossover trial of morphine sulphate for the treatment of pulmonary Fibrosis Cough
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Zhe Wu, Winston Banya, Nazia Chaudhuri, Ira Jakupovic, Toby M. Maher, Brijesh Patel, Lisa G. Spencer, Muhunthan Thillai, Alex West, John Westoby, Marlies Wijsenbeek, Jaclyn Smith, and Philip L. Molyneaux
- Subjects
Morphine ,Cough ,Idiopathic pulmonary fibrosis ,Interstitial lung disease ,Quality of life ,Medicine (General) ,R5-920 - Abstract
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease that leads to lung scarring. Cough is reported by 85% of patients with IPF and can be a distressing symptom with a significant impact on patients’ quality of life. There are no proven effective therapies for IPF-related cough. Whilst morphine is frequently used as a palliative agent for breathlessness in IPF, its effects on cough have never been tested. PAciFy Cough is a multicenter, double-blind, placebo-controlled, crossover trial of morphine sulphate for the treatment of cough in IPF. Methods We will recruit 44 subjects with IPF prospectively from three interstitial lung disease units in the UK, namely the Royal Brompton Hospital, Manchester University NHS Foundation Trust (MFT) and Aintree University Hospital NHS Foundation Trust. Patients will be randomised (1:1) to either placebo twice daily or morphine sulphate 5 mg twice daily for 14 days. They will then crossover after a 7-day washout period. The primary endpoint is the percent change in daytime cough frequency (coughs per hour) from baseline as assessed by objective cough monitoring at day 14 of treatment. Discussion This multicentre, randomised trial will assess the effect of opioids on cough counts and cough associated quality of life in IPF subjects. If proven to be an effective intervention, it represents a readily available treatment for patients. Trial registration The study was approved by the UK Medicines and Healthcare Regulatory Agency (Ref: CTA 21268/0224/001-0001 – EUDRACT 2019-003571-19 – Protocol Number RBH2019/001) on 08 April 2020, in compliance with the European Clinical Trials Directive and the Medicines for Human Use (Clinical Trials) Regulations 2004 and its subsequent amendments. The study was provided with ethical approval by the London Brent Research Ethics Committee (Ref: 20/LO/0368) on 21 May 2020 and is registered with clinicaltrials.gov (NCT04429516) on 12 June 2020, available at https://clinicaltrials.gov/ct2/show/NCT04429516
- Published
- 2022
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91. Characterisation of Ferritin–Lymphocyte Ratio in COVID-19
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Alexander Liu, Robert Hammond, Kenneth Chan, Chukwugozie Chukwuenweniwe, Rebecca Johnson, Duaa Khair, Eleanor Duck, Oluwaseun Olubodun, Kristian Barwick, Winston Banya, James Stirrup, Peter D. Donnelly, Juan Carlos Kaski, and Anthony R. M. Coates
- Subjects
coronavirus disease 19 ,ferritin–lymphocyte ratio ,inflammatory biomarkers ,risk stratification ,C-reactive protein ,white cell count ,Biology (General) ,QH301-705.5 - Abstract
Introduction: The ferritin–lymphocyte ratio (FLR) is a novel inflammatory biomarker for the assessment of acute COVID-19 patients. However, the prognostic value of FLR for predicting adverse clinical outcomes in COVID-19 remains unclear, which hinders its clinical translation. Methods: We characterised the prognostic value of FLR in COVID-19 patients, as compared to established inflammatory markers. Results: In 217 study patients (69 years [IQR: 55–82]; 60% males), FLR was weakly correlated with CRP (R = 0.108, p = 0.115) and white cell count (R = −0.144; p = 0.034). On ROC analysis, an FLR cut-off of 286 achieved a sensitivity of 86% and a specificity of 30% for predicting inpatient mortality (AUC 0.60, 95% CI: 0.53–0.67). The negative predictive values of FLR for ruling out mortality, non-invasive ventilation requirement and critical illness (intubation and/or ICU admission) were 86%, 85% and 93%, respectively. FLR performed similarly to CRP (AUC 0.60 vs. 0.64; p = 0.375) for predicting mortality, but worse than CRP for predicting non-fatal outcomes (all p < 0.05). On Kaplan–Meier analysis, COVID-19 patients with FLR values > 286 had worse inpatient survival than patients with FLR ≤ 286, p = 0.041. Conclusions: FLR has prognostic value in COVID-19 patients, and appears unrelated to other inflammatory markers such as CRP and WCC. FLR exhibits high sensitivity and negative predictive values for adverse clinical outcomes in COVID-19, and may be a good “rule-out” test. Further work is needed to improve the sensitivity of FLR and validate its role in prospective studies for guiding clinical management.
- Published
- 2023
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92. Low CRB-65 Scores Effectively Rule out Adverse Clinical Outcomes in COVID-19 Irrespective of Chest Radiographic Abnormalities
- Author
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Alexander Liu, Robert Hammond, Kenneth Chan, Chukwugozie Chukwuenweniwe, Rebecca Johnson, Duaa Khair, Eleanor Duck, Oluwaseun Olubodun, Kristian Barwick, Winston Banya, James Stirrup, Peter D. Donnelly, Juan Carlos Kaski, and Anthony R. M. Coates
- Subjects
coronavirus disease 2019 ,CRB-65 ,chest X-ray ,diagnostic performance ,inflammatory markers ,prognosis ,Biology (General) ,QH301-705.5 - Abstract
Background: CRB-65 (Confusion; Respiratory rate ≥ 30/min; Blood pressure ≤ 90/60 mmHg; age ≥ 65 years) is a risk score for prognosticating patients with COVID-19 pneumonia. However, a significant proportion of COVID-19 patients have normal chest X-rays (CXRs). The influence of CXR abnormalities on the prognostic value of CRB-65 is unknown, limiting its wider applicability. Methods: We assessed the influence of CXR abnormalities on the prognostic value of CRB-65 in COVID-19. Results: In 589 study patients (71 years (IQR: 57–83); 57% males), 186 (32%) had normal CXRs. On ROC analysis, CRB-65 performed similarly in patients with normal vs. abnormal CXRs for predicting inpatient mortality (AUC 0.67 ± 0.05 vs. 0.69 ± 0.03). In patients with normal CXRs, a CRB-65 of 0 ruled out mortality, NIV requirement and critical illness (intubation and/or ICU admission) with negative predictive values (NPVs) of 94%, 98% and 99%, respectively. In patients with abnormal CXRs, a CRB-65 of 0 ruled out the same endpoints with NPVs of 91%, 83% and 86%, respectively. Patients with low CRB-65 scores had better inpatient survival than patients with high CRB-65 scores, irrespective of CXR abnormalities (all p < 0.05). Conclusions: CRB-65, CXR and CRP are independent predictors of mortality in COVID-19. Adding CXR findings (dichotomised to either normal or abnormal) to CRB-65 does not improve its prognostic accuracy. A low CRB-65 score of 0 may be a good rule-out test for adverse clinical outcomes in COVID-19 patients with normal or abnormal CXRs, which deserves prospective validation.
- Published
- 2023
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93. Effect of Ozone Stresses on Growth and Secondary Plant Metabolism of Brassica campestris L. ssp. chinensis
- Author
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Young Jong Han, Winston Beck, Inga Mewis, Nadja Förster, and Christian Ulrichs
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ozone ,plant growth ,photopigments ,glucosinolates ,urban horticulture ,Plant culture ,SB1-1110 - Abstract
Determining plant responses to hazardous air pollutants is critical in predicting food security programs and challenges in the future. This study aimed to determine the effects of various ozone levels on plant growth responses (leaf area, dry matter, and number of leaves) and biochemical quality (photopigments and glucosinolates) on Brassica campestris L. ssp. chinensis (Pak-Choi). The experiment was conducted within test chambers under different ozone concentrations (60, 150, and 240 ppb for 2 h/day). Leaf area and dry matter were negatively correlated with increasing ozone concentrations, but the number of leaves was not affected by ozone treatment. Lycopene and chlorophylls also showed the same tendency. Even if the ambient ozone concentration was only elevated for a short time, various glucosnilates (GLS) have been diversely affected. The total aliphatic GLS content was reduced. In contrast, the total indole GLS increased at the highest ozone concentration, and the aromatic GLS significantly increased and then decreased as the ozone concentration level increased. These results provide evidence of the strong effect of ozone stress on the plant quality of Pak-Choi with respect to certain secondary plant metabolites. These findings provide an understanding of elevated ozone effects in urban horticulture sites on the growth and metabolite profiling of Brassica plants.
- Published
- 2023
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94. The Fight at Soldier Crossing, 1884: Military Considerations in Canyon Country
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ROBERT S. MCPHERSON and WINSTON B. HURST
- Published
- 2002
95. Management of End Stage Renal Disease in Persons Living with HIV: A Cost-Effectiveness Analysis
- Author
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Winston B Joe and Ellen F. Eaton
- Subjects
Gerontology ,medicine.medical_specialty ,business.industry ,Human immunodeficiency virus (HIV) ,virus diseases ,Cost-effectiveness analysis ,Poster Abstract ,medicine.disease_cause ,End stage renal disease ,Abstracts ,Infectious Diseases ,Text mining ,Oncology ,medicine ,Intensive care medicine ,business - Abstract
Background HIV+ kidney transplant (KT) for persons living with HIV (PLWH) is both safe and effective, with comparable patient and graft survival rates relative to HIV- KT. The objective of this study was to evaluate the cost-effectiveness of HIV+ KT relative to HIV- KT and dialysis. Methods A decision-tree framework was used to assess the cost-effectiveness of the above treatment options for PLWH. Clinical outcomes at 3 years for KT and effectiveness data (expressed in QALYs) were abstracted from previous publications, when available. Costs were assigned from a payer’s perspective using the US Renal Data System and published literature (expressed in 2014 USD). This analysis assumed a three-year time horizon. Sensitivity analyses were explored to understand how changes in 1) acute KT rejection and 2) KT failure impact cost effectiveness. Limitations include small sample size and short follow up time in referenced studies and a lack of health utility data in HIV positive persons with renal failure. We used TreeAge Software (Williamstown, MA). Results HIV+ KT was most cost effective ($299,904/QALY) while both HIV- KT ($329,676) and dialysis ($444,645) were dominated, meaning more costly and less effective. Results were sensitive to the higher KT failure (26% vs. 16%) and acute rejection (39% vs. 17%) observed with HIV- KT relative to HIV+ KT. In sensitivity analysis, as HIV+ KT rejection rates approach 20%, HIV- KT becomes a cost-effective option. As HIV+ KT failure rates approach 26%, HIV- KT becomes cost effective. Conclusion Despite its limitations, this analysis demonstrates that HIV+ kidney transplantation is a cost-effective alternative for PLWH under certain conditions. As KT outcomes, like graft failure and acute rejection rates, continue to improve, it is likely that both HIV positive and negative KT will be cost-effective alternatives to dialysis. Disclosures All authors: No reported disclosures.
- Published
- 2017
96. Normal high-sensitivity cardiac troponin for ruling-out inpatient mortality in acute COVID-19.
- Author
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Alexander Liu, Robert Hammond, Kenneth Chan, Chukwugozie Chukwuenweniwe, Rebecca Johnson, Duaa Khair, Eleanor Duck, Oluwaseun Olubodun, Kristian Barwick, Winston Banya, James Stirrup, Peter D Donnelly, Juan Carlos Kaski, and Anthony R M Coates
- Subjects
Medicine ,Science - Abstract
IntroductionAssessment of inpatient mortality risk in COVID-19 patients is important for guiding clinical decision-making. High sensitivity cardiac troponin T (hs-cTnT) is a biomarker of cardiac injury associated with a worse prognosis in COVID-19. We explored how hs-cTnT could potentially be used in clinical practice for ruling in and ruling out mortality in COVID-19.MethodWe tested the diagnostic value of hs-cTnT in laboratory-confirmed COVID-19 patients (≥18 years old) admitted to the Royal Berkshire Hospital (UK) between 1st March and 10th May 2020. A normal hs-cTnT was defined as a value within the 99th percentile of healthy individuals (≤14 ng/L), and an elevated hs-cTnT was defined as >14 ng/L. Adverse clinical outcome was defined as inpatient mortality related to COVID-19.ResultsA total of 191 COVID-19 patients (62% male; age 66±16 years) had hs-cTnT measured on admission. Of these patients, 124 (65%) had elevated hs-cTnT and 67 (35%) had normal hs-cTnT. On a group level, patients with elevated hs-cTnT had worse inpatient survival (p = 0.0014; Kaplan-Meier analysis) and higher risk of inpatient mortality (HR 5.84 [95% CI 1.29-26.4]; p = 0.02; Cox multivariate regression) compared to patients with normal hs-cTnT. On a per-patient level, a normal hs-cTnT had a negative predictive value of 94% (95% CI: 85-98%) for ruling out mortality, whilst an elevated hs-cTnT had a low positive predictive value of 38% (95% CI: 39-47%) for ruling in mortality.ConclusionsIn this study cohort of COVID-19 patients, the potential clinical utility of hs-cTnT appears to rest in ruling out inpatient mortality. This finding, if prospectively validated in a larger study, may allow hs-cTnT to become an important biomarker to facilitate admission-avoidance and early safe discharge.
- Published
- 2023
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97. Fibrin gel versus papain gel in the healing of chronic venous ulcers: A double-blind randomized controlled trial
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de Araújo, Illymack CF, primary, Defune, Elenice, additional, Abbade, Luciana PF, additional, Miot, Hélio A, additional, Bertanha, Matheus, additional, de Carvalho, Lídia R, additional, Ferreira, Rosana R, additional, and Yoshida, Winston B, additional
- Published
- 2016
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98. Integrative meta-analysis identifies microRNA-regulated networks in infantile hemangioma
- Author
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Bertoni, Natália, primary, Pereira, Lied M. S., additional, Severino, Fábio E., additional, Moura, Regina, additional, Yoshida, Winston B., additional, and Reis, Patricia P., additional
- Published
- 2016
- Full Text
- View/download PDF
99. The Relationship of Self-Esteem and Self-Efficacy to Student Engagement among Gay and Lesbian Students: A Case Study
- Author
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Jurial, Maria Gracia, primary, Otig, Vergie S., additional, and Gallinero, Winston B., additional
- Published
- 2015
- Full Text
- View/download PDF
100. FRailty and Arterial stiffness – the role of oXidative stress and Inflammation (FRAXI study)
- Author
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Ekow Mensah, Khalid Ali, Winston Banya, Frances Ann Kirkham, Manuela Mengozzi, Pietro Ghezzi, and Chakravarthi Rajkumar
- Subjects
Medicine (General) ,R5-920 - Abstract
Objective: There is an association between frailty and arterial stiffness. However, arterial stiffness does not uniformly correlate with the spectrum of frailty states. Both oxidative stress and inflammaging contribute to vascular ageing. There are no human studies exploring links between arterial stiffness, oxidative stress, inflammaging and frailty. Our objective is to investigate arterial stiffness and inflammaging as predictors of frailty states. Methods: An observational longitudinal cohort study will be used to examine the association between arterial stiffness, oxidative stress and inflammation in 50 older adults (⩾70 years) with clinical frailty scores (CFS) ⩽6 over 6 months. All study measurements will be taken at baseline. Frailty assessment will include hand-grip strength, timed-up and go test, mini-mental state examination, geriatric depression scale and sarcopenia using body composition measurements with Tanita ® . Arterial stiffness measurements will include carotid-femoral pulse wave velocity (cfPWV) and carotid-radial pulse wave velocity (crPWV) using Complior (Alam Medical, France). CAVI device will measure Cardio-ankle vascular index and ankle brachial index (ABI). Oxidative stress blood markers nitrotyrosine (NT) and 8-hydroxy-2’-deoxyguanosin (8-oxo-dG) and inflammation markers high-sensitive C-reactive protein (hs-CRP) and interlukin-6(IL-6) will be measured at baseline and 6 month along with lipid profile and glycated haemoglobin. Results (data analysis plan): Descriptive statistics for continuous data using means and standard deviations for normality distributed variables or medians and inter-quartile ranges for skewed variables will be used. Participants will be categorised into CFS 1-3, and CFS 4-6. Categorical data will use frequencies and comparison between groups. Change in frailty between the groups over 6 months will be compared using paired t-test. Simple linear regression will be done between frailty measures, arterial stiffness, inflammation and oxidative stress biomarkers. Significance will be at P < .05. Conclusion: This study data will inform a larger, multi-centre study exploring further the interplay between frailty, biomarkers and arterial stiffness parameters.
- Published
- 2022
- Full Text
- View/download PDF
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