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56. Three-dimensional echocardiography of the athlete’s heart: a comparison with cardiac magnetic resonance imaging

Author

De Bosscher, Ruben, Claeys, Mathias, Dausin, Christoph, Goetschalckx, Kaatje, Claus, Piet, Herbots, Lieven, Ghekiere, Olivier, Van De Heyning, Caroline, Paelinck, Bernard, Janssens, Kristel, Wright, Leah, Flannery, Michael Darragh, La Gerche, Andre, Willems, Rik, Heidbüchel, Hein, Bogaert, Jan, Claessen, Guido, and Pro@Heart Consortium

Subjects
Computer. Automation, Human medicine
Abstract

Three-dimensional echocardiography (3DE) is the most accurate cardiac ultrasound technique to assess cardiac structure. 3DE has shown close correlation with cardiac magnetic resonance imaging (CMR) in various populations. There is limited data on the accuracy of 3DE in athletes and its value in detecting alterations during follow-up. Indexed left and right ventricular end-diastolic volume (LVEDVi, RVEDVi), end-systolic volume, ejection fraction (LVEF, RVEF) and left ventricular mass (LVMi) were assessed by 3DE and CMR in two-hundred and one competitive endurance athletes (79% male) from the Pro@Heart trial. Sixty-four athletes were assessed at 2 year follow-up. Linear regression and Bland-Altman analyses compared 3DE and CMR at baseline and follow-up. Interquartile analysis evaluated the agreement as cardiac volumes and mass increase. 3DE showed strong correlation with CMR (LVEDVi r = 0.91, LVEF r = 0.85, LVMi r = 0.84, RVEDVi r = 0.84, RVEF r = 0.86 p < 0.001). At follow up, the percentage change by 3DE and CMR were similar ( increment LVEDVi r = 0.96 bias - 0.3%, increment LVEF r = 0.94, bias 0.7%, increment LVMi r = 0.94 bias 0.8%, increment RVESVi r = 0.93, bias 1.2%, increment RVEF r = 0.87 bias 0.4%). 3DE underestimated volumes (LVEDVi bias - 18.5 mL/m(2), RVEDVi bias - 25.5 mL/m(2)) and the degree of underestimation increased with larger dimensions (Q1vsQ4 LVEDVi relative bias - 14.5 versus - 17.4%, p = 0.016; Q1vsQ4 RVEDVi relative bias - 17 versus - 21.9%, p = 0.005). Measurements of cardiac volumes, mass and function by 3DE correlate well with CMR and 3DE accurately detects changes over time. 3DE underestimates volumes and the relative bias increases with larger cardiac size.

Published
2022

57. Long‐term outcome after upgrade to cardiac resynchronization therapy: A propensity score‐matched analysis.

Author

Trenson, Sander, Voros, Gabor, Martens, Pieter, Ingelaere, Sebastian, Betschart, Pascal, Voigt, Jens‐Uwe, Dupont, Matthias, Breitenstein, Alexander, Steffel, Jan, Willems, Rik, Ruschitzka, Frank, Mullens, Wilfried, Winnik, Stephan, and Vandenberk, Bert

Subjects
HEART assist devices, CARDIAC pacing, IMPLANTABLE cardioverter-defibrillators, PROPENSITY score matching, HEART failure patients, CARDIAC pacemakers, KIDNEY physiology
Abstract

Aim: Cardiac resynchronization therapy (CRT) is a cornerstone in the management of chronic heart failure in patients with a broad or paced QRS. However, data on long‐term outcome after upgrade to CRT are scarce. Methods and results: This international, multicentre retrospective registry included 2275 patients who underwent a de novo or upgrade CRT implantation with a mean follow‐up of 3.6 ± 2.7 years. The primary composite endpoint included all‐cause mortality, heart transplantation, or ventricular assist device implantation. The secondary endpoint was first heart failure admission. Multivariable Cox regression and propensity score matching (PSM) analyses were performed. Patients who underwent CRT upgrade (n = 605, 26.6%) were less likely female (19.7% vs. 28.8%, p < 0.001), more often had ischeemic cardiomyopathy (49.8% vs. 40.2%, p < 0.001), and had worse renal function (median estimated glomerular filtration rate 50.3 ml/min/1.73 m2 [35.8–69.5] vs. 59.9 ml/min/1.73 m2 [43.0–76.5], p < 0.001). The incidence rate of the composite endpoint was 10.8%/year after CRT upgrade versus 7.1%/year for de novo implantations (p < 0.001). PSM for the primary endpoint resulted in 488 pairs. After propensity score matching, upgrade to CRT was associated with a higher chance to reach the composite endpoint (multivariable hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.08–1.70), for both upgrade from pacemaker (multivariable HR 1.33, 95% CI 1.03–1.70) and implantable cardioverter‐defibrillator (ICD) (multivariable HR 1.40, 95% CI 1.01–1.95). PSM for the secondary endpoint resulted in 277 pairs. After PSM, upgrade to CRT was associated with a higher chance for heart failure admission (HR 1.74, 95% CI 1.26–2.41). Conclusion: In this retrospective analysis, the outcome of patients who underwent upgrades to CRT differed significantly from patients who underwent de novo CRT implantation, particularly for upgrades from ICD. Importantly, this difference in outcome does not imply a causal relation between therapy and outcome but rather a difference between two different patient populations. [ABSTRACT FROM AUTHOR]

Published
2024
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58. QRS complex and T wave planarity for the efficacy prediction of automatic implantable defibrillators.

Author

Hnatkova, Katerina, Andršová, Irena, Novotný, Tomáš, Vanderberk, Bert, Sprenkeler, David, Junttila, Juhani, Reichlin, Tobias, Schlögl, Simon, Vos, Marc A., Friede, Tim, Bauer, Axel, Huikuri, Heikki V., Willems, Rik, Schmidt, Georg, Sticherling, Christian, Zabel, Markus, and Malik, Marek

Subjects
IMPLANTABLE cardioverter-defibrillators, HEART failure, CARDIAC pacing
Published
2024
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59. TEMPORARY REMOVAL: Lateral QRS amplitude is independently associated with outcome after cardiac resynchronization therapy: advancing patient selection?

Author

Trenson, Sander, Kahr, Peter C., Schwaiger, Judith M., Betschart, Pascal, Kuster, Joël, Vandenberk, Bert, Duchenne, Jürgen, Beela, Ahmed S., Stankovic, Ivan, Voros, Gabor, Flammer, Andreas J., Schindler, Matthias, Saguner, Ardan M., Willems, Rik, Ruschitzka, Frank, Steffel, Jan, Breitenstein, Alexander, Voigt, Jens-Uwe, and Winnik, Stephan

Published
2024
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64. Impella to Resist the Storm

Author

Castelein, Thomas, Balthazar, Tim, Adriaenssens, Tom, Ector, Joris, Janssens, Stefan, Meyns, Bart, Verbelen, Tom, Willems, Rik, Wilson, James, and Vandenbriele, Christophe

Published
2020
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65. A unified framework for multi-lead ECG characterization using Laplacian Eigenmaps

Author

Villa, Amalia, Ingelaere, Sebastian, Jacobs, Ben, Vandenberk, Bert, Van Huffel, Sabine, Willems, Rik, and Varon, Carolina

Subjects
Laplacian Eigenmaps, manifold learning, ECG signal processing, dimensionality reduction
Abstract

BACKGROUND: The analysis of multi-lead electrocardiographic (ECG) signals requires integrating the information derived from each lead to reach clinically relevant conclusions. This analysis could benefit from methods compacting the information in those leads into lower-dimensional representations (i.e., 2 or 3 dimensions instead of 12). OBJECTIVE: We propose Laplacian Eigenmaps (LE) to create a unified framework where ECGs from different subjects can be compared and their abnormalities are enhanced. APPROACH: We conceive a normal reference ECG space based on LE, calculated using signals of healthy subjects in sinus rhythm. Signals from new subjects can be mapped onto this reference space creating a loop per heartbeat that captures ECG abnormalities. A set of parameters, based on distance metrics and on the shape of loops, are proposed to quantify the differences between subjects. MAIN RESULTS: This methodology was applied to find structural and arrhythmogenic changes in the ECG. The LE framework consistently captured the characteristics of healthy ECGs, confirming that normal signals behaved similarly in the LE space. Significant differences between normal signals and those from patients with ischemic heart disease or dilated cardiomyopathy were detected. In contrast, LE biomarkers did not identify differences between patients with cardiomyopathy and a history of ventricular arrhythmia and their matched controls. SIGNIFICANCE: This LE unified framework offers a new representation of multi-lead signals, reducing dimensionality while enhancing imperceptible abnormalities and enabling the comparison of signals of different subjects. ispartof: Physiol Meas ispartof: location:England status: Published online

Published
2023

69. Septal Scar Detection in Patients With Left Bundle Branch Block Using Echocardiographic Shear Wave Elastography

Author

Wouters, Laurine, primary, Duchenne, Jürgen, additional, Bézy, Stéphanie, additional, Papangelopoulou, Konstantina, additional, Puvrez, Alexis, additional, Klop, Boudewijn, additional, Minten, Lennert, additional, Bogaert, Jan, additional, Willems, Rik, additional, Vörös, Gàbor, additional, D’hooge, Jan, additional, and Voigt, Jens-Uwe, additional

Published
2023
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72. Lifelong endurance exercise and its relation with coronary atherosclerosis

Author

De Bosscher, Ruben, primary, Dausin, Christophe, additional, Claus, Piet, additional, Bogaert, Jan, additional, Dymarkowski, Steven, additional, Goetschalckx, Kaatje, additional, Ghekiere, Olivier, additional, Van De Heyning, Caroline M, additional, Van Herck, Paul, additional, Paelinck, Bernard, additional, Addouli, Haroun El, additional, La Gerche, André, additional, Herbots, Lieven, additional, Willems, Rik, additional, Heidbuchel, Hein, additional, and Claessen, Guido, additional

Published
2023
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75. Visual Presence of Mechanical Dyssynchrony Combined With Septal Scarring Identifies Responders to Cardiac Resynchronization Therapy

Author

Duchenne, Jürgen, primary, Larsen, Camilla K., additional, Cvijic, Marta, additional, Galli, Elena, additional, Aalen, John M., additional, Klop, Boudewijn, additional, Puvrez, Alexis, additional, Mirea, Oana, additional, Bézy, Stéphanie, additional, Minten, Lennert, additional, Sirnes, Per Anton, additional, Khan, Faraz H., additional, Voros, Gabor, additional, Willems, Rik, additional, Penicka, Martin, additional, Kongsgård, Erik, additional, Hopp, Einar, additional, Bogaert, Jan, additional, Smiseth, Otto A., additional, Donal, Erwan, additional, and Voigt, Jens-Uwe, additional

Published
2022
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76. Altered multicellular composition and unique myocyte phenotypes characterize the arrhythmogenic infarct border zone

Author

Ekhteraeitousi, Samaneh, primary, Amoni, Matthew, additional, Vermoortele, Dylan, additional, Puertas, Rosa Donate, additional, Youness, Mohamad, additional, Ingelaere, Sebastian, additional, Willems, Rik, additional, Claus, Piet, additional, Nagaraju, Chandan K., additional, Thienpont, Bernard, additional, Sipido, Karin, additional, and Roderick, H. Llewelyn, additional

Published
2022
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82. Rationale and design of the PROspective ATHletic Heart (Pro@Heart) study : long-term assessment of the determinants of cardiac remodelling and its clinical consequences in endurance athletes

Author

De Bosscher, Ruben, Dausin, Christophe, Janssens, Kristel, Bogaert, Jan, Elliott, Adrian, Ghekiere, Olivier, Van De Heyning, Caroline M, Sanders, Prashanthan, Kalman, Jonathan, Fatkin, Diane, Herbots, Lieven, Willems, Rik, Heidbuchel, Hein, La Gerche, André, Claessen, Guido, consortium, pro@heart, Favere, Kasper, Pro Heart Consortium, De Bosscher, Ruben, Dausin, Christophe, Janssens , Kristel, Bogaert , Jan, Elliott, Adrian, GHEKIERE, Olivier, Van De Heyning, Caroline M., Sanders, Prashanthan, Kalman, Jonathan, Fatkin, Diane, HERBOTS, Lieven, Willems, Rik, HEIDBUCHEL, Hein, La Gerche, Andre, and Claessen , Guido

Subjects
RISK, ARRHYTHMIAS, Science & Technology, RIGHT-VENTRICULAR DYSFUNCTION, Economics, VIGOROUS EXERCISE, Physical Therapy, Sports Therapy and Rehabilitation, BLOOD-PRESSURE, PREVALENCE, PHYSICAL-ACTIVITY, ETHNIC-DIFFERENCES, SUDDEN-DEATH, Sociology, ATRIAL-FIBRILLATION, Medicine and Health Sciences, Orthopedics and Sports Medicine, Life Sciences & Biomedicine, Sport Sciences
Abstract

BackgroundExercise-induced cardiac remodelling (EICR) results from the structural, functional and electrical adaptations to exercise. Despite similar sports participation, EICR varies and some athletes develop phenotypic features that overlap with cardiomyopathies. Training load and genotype may explain some of the variation; however, exercise ‘dose’ has lacked rigorous quantification. Few have investigated the association between EICR and genotype.Objectives(1) To identify the impact of training load and genotype on the variance of EICR in elite endurance athletes and (2) determine how EICR and its determinants are associated with physical performance, health benefits and cardiac pathology.MethodsThe Pro@Heart study is a multicentre prospective cohort trial. Three hundred elite endurance athletes aged 14–23 years will have comprehensive cardiovascular phenotyping using echocardiography, cardiac MRI, 12-lead ECG, exercise-ECG and 24-hour-Holter monitoring. Genotype will be determined using a custom cardiomyopathy gene panel and high-density single-nucleotide polymorphism arrays. Follow-up will include online tracking of training load. Cardiac phenotyping will be repeated at 2, 5, 10 and 20 years.ResultsThe primary endpoint of the Pro@Heart study is the association of EICR with both training load and genotype. The latter will include rare variants in cardiomyopathy-associated genes and polygenic risk scores for cardiovascular traits. Secondary endpoints are the incidence of atrial and ventricular arrhythmias, physical performance and health benefits and their association with training load and genotype.ConclusionThe Pro@Heart study is the first long-term cohort study to assess the impact of training load and genotype on EICR.Trial registration numberNCT05164328; ACTRN12618000716268.

Published
2022

83. eServices for Hospital Equipment

Author

de Jonge, Merijn, van der Linden, Wim, Willems, Rik, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Krämer, Bernd J., editor, Lin, Kwei-Jay, editor, and Narasimhan, Priya, editor

Published
2007
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85. Lifelong endurance exercise and its relation with coronary atherosclerosis.

Author

Bosscher, Ruben De, Dausin, Christophe, Claus, Piet, Bogaert, Jan, Dymarkowski, Steven, Goetschalckx, Kaatje, Ghekiere, Olivier, Heyning, Caroline M Van De, Herck, Paul Van, Paelinck, Bernard, Addouli, Haroun El, Gerche, André La, Herbots, Lieven, Willems, Rik, Heidbuchel, Hein, Claessen, Guido, Claeys, Mathias, Hespel, Peter, Dresselaers, Tom, and Miljoen, Hielko

Subjects
ENDURANCE athletes, MALE athletes, CORONARY artery disease, SPORTS participation, ENDURANCE sports, CORONARY angiography, CARDIOVASCULAR diseases risk factors
Abstract

Aims The impact of long-term endurance sport participation (on top of a healthy lifestyle) on coronary atherosclerosis and acute cardiac events remains controversial. Methods and results The Master@Heart study is a well-balanced prospective observational cohort study. Overall, 191 lifelong master endurance athletes, 191 late-onset athletes (endurance sports initiation after 30 years of age), and 176 healthy non-athletes, all male with a low cardiovascular risk profile, were included. Peak oxygen uptake quantified fitness. The primary endpoint was the prevalence of coronary plaques (calcified, mixed, and non-calcified) on computed tomography coronary angiography. Analyses were corrected for multiple cardiovascular risk factors. The median age was 55 (50–60) years in all groups. Lifelong and late-onset athletes had higher peak oxygen uptake than non-athletes [159 (143–177) vs. 155 (138–169) vs. 122 (108–138) % predicted]. Lifelong endurance sports was associated with having ≥1 coronary plaque [odds ratio (OR) 1.86, 95% confidence interval (CI) 1.17–2.94], ≥ 1 proximal plaque (OR 1.96, 95% CI 1.24–3.11), ≥ 1 calcified plaques (OR 1.58, 95% CI 1.01–2.49), ≥ 1 calcified proximal plaque (OR 2.07, 95% CI 1.28–3.35), ≥ 1 non-calcified plaque (OR 1.95, 95% CI 1.12–3.40), ≥ 1 non-calcified proximal plaque (OR 2.80, 95% CI 1.39–5.65), and ≥1 mixed plaque (OR 1.78, 95% CI 1.06–2.99) as compared to a healthy non-athletic lifestyle. Conclusion Lifelong endurance sport participation is not associated with a more favourable coronary plaque composition compared to a healthy lifestyle. Lifelong endurance athletes had more coronary plaques, including more non-calcified plaques in proximal segments, than fit and healthy individuals with a similarly low cardiovascular risk profile. Longitudinal research is needed to reconcile these findings with the risk of cardiovascular events at the higher end of the endurance exercise spectrum. [ABSTRACT FROM AUTHOR]

Published
2023
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87. Inequality between women and men in ICD implantation

Author

Ingelaere, Sebastian, primary, Hoffmann, Ruben, additional, Guler, Ipek, additional, Vijgen, Johan, additional, Mairesse, Georges H., additional, Blankoff, Ivan, additional, Vandekerckhove, Yves, additional, le Polain de Waroux, Jean-Benoit, additional, Vandenberk, Bert, additional, and Willems, Rik, additional

Published
2022
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88. Temporal Changes in Beat‐to‐Beat Variability of Repolarization Predict Imminent Nonsustained Ventricular Tachycardia in Patients With Ischemic and Nonischemic Dilated Cardiomyopathy

Author

Amoni, Matthew, primary, Ingelaere, Sebastian, additional, Moeyersons, Jonathan, additional, Vandenberk, Bert, additional, Claus, Piet, additional, Lemmens, Robin, additional, Van Huffel, Sabine, additional, Sipido, Karin, additional, Varon, Carolina, additional, and Willems, Rik, additional

Published
2022
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89. Can nuclear imaging accurately detect scar in ischemic cardiac resynchronization therapy candidates?

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de médecine nucléaire, Degtiarova, Ganna, Claus, Piet, Duchenne, Jürgen, Schramm, Georg, Nuyts, Johan, Bogaert, Jan, Vöros, Gabor, Willems, Rik, Verberne, Hein J, Voigt, Jens-Uwe, Gheysens, Olivier, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de médecine nucléaire, Degtiarova, Ganna, Claus, Piet, Duchenne, Jürgen, Schramm, Georg, Nuyts, Johan, Bogaert, Jan, Vöros, Gabor, Willems, Rik, Verberne, Hein J, Voigt, Jens-Uwe, and Gheysens, Olivier

Abstract

Accurate scar assessment is crucial in cardiac resynchronization therapy (CRT) candidates, since its presence is a negative predictor for CRT response. Therefore, we assessed the performance of different PET parameters to detect scar in CRT candidates. Twenty-nine CRT candidates underwent 18F-fluorodeoxyglucose (18F-FDG)-PET/computed tomography (CT), resting 13N-NH3-PET/CT and cardiac magnetic resonance (CMR) prior to CRT implantation. Segmental 18F-FDG uptake, late 13N-NH3 uptake and absolute myocardial blood flow (MBF) were evaluated for scar detection using late gadolinium enhancement (LGE) CMR as reference. A receiver operator characteristic (ROC) area under the curve (AUC) ≥0.8 indicated a good accuracy of the methods evaluated. Scar was present in 111 of 464 segments. None of the approaches could reliably identify segments with nontransmural scar, except for 18F-FDG uptake in the lateral wall (AUC 0.83). Segmental transmural scars could be detected with all methods (AUC ≥ 0.8), except for septal 18F-FDG uptake and MBF in the inferior wall (AUC < 0.8). Late 13N-NH3 uptake was the best parameter for transmural scar detection, independent of its location, with a sensitivity of 80% and specificity of 92% using a cutoff of 66% of the maximum tracer activity. Late 13N-NH3 uptake is superior to 13N-NH3 MBF and 18F-FDG in detecting transmural scar, independently of its location. However, none of the tested PET parameters was able to accurately detect nontransmural scar.

Published
2022

90. QRS micro-fragmentation as a mortality predictor

Author

Arts Assistenten Cardiologie, Medische Fysiologie, Circulatory Health, Hnatkova, Katerina, Andršová, Irena, Novotný, Tomáš, Britton, Annie, Shipley, Martin, Vandenberk, Bert, Sprenkeler, David J, Junttila, Juhani, Reichlin, Tobias, Schlögl, Simon, Vos, Marc A, Friede, Tim, Bauer, Axel, Huikuri, Heikki V, Willems, Rik, Schmidt, Georg, Franz, Michael R, Sticherling, Christian, Zabel, Markus, Malik, Marek, Arts Assistenten Cardiologie, Medische Fysiologie, Circulatory Health, Hnatkova, Katerina, Andršová, Irena, Novotný, Tomáš, Britton, Annie, Shipley, Martin, Vandenberk, Bert, Sprenkeler, David J, Junttila, Juhani, Reichlin, Tobias, Schlögl, Simon, Vos, Marc A, Friede, Tim, Bauer, Axel, Huikuri, Heikki V, Willems, Rik, Schmidt, Georg, Franz, Michael R, Sticherling, Christian, Zabel, Markus, and Malik, Marek

Published
2022

91. Q waves are the strongest electrocardiographic variable associated with primary prophylactic implantable cardioverter-defibrillator benefit: a prospective multicentre study

Author

Medische Fysiologie, Circulatory Health, Pelli, Ari, Junttila, M Juhani, Kenttä, Tuomas V, Schlögl, Simon, Zabel, Markus, Malik, Marek, Reichlin, Tobias, Willems, Rik, Vos, Marc A, Harden, Markus, Friede, Tim, Sticherling, Christian, Huikuri, Heikki V, Medische Fysiologie, Circulatory Health, Pelli, Ari, Junttila, M Juhani, Kenttä, Tuomas V, Schlögl, Simon, Zabel, Markus, Malik, Marek, Reichlin, Tobias, Willems, Rik, Vos, Marc A, Harden, Markus, Friede, Tim, Sticherling, Christian, and Huikuri, Heikki V

Published
2022

96. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Piccini, Jonathan P, primary, Caso, Valeria, additional, Connolly, Stuart J, additional, Fox, Keith A A, additional, Oldgren, Jonas, additional, Jones, W Schuyler, additional, Gorog, Diana A, additional, Durdil, Václav, additional, Viethen, Thomas, additional, Neumann, Christoph, additional, Mundl, Hardi, additional, Patel, Manesh R, additional, Auer, Johann, additional, Hubauer, Martin, additional, Pandzic, Sead, additional, Preishuber, Eva, additional, Primus-Grabscheit, Carina, additional, Reitgruber, Dietmar, additional, Schmalzer, Florian, additional, Adlbrecht, Christopher, additional, Schober, Andreas, additional, Hajos, Johannes, additional, Keil, Christoph, additional, Schratter, Alexandra, additional, Frick, Matthias, additional, Benda, Magdalena Anna, additional, Mächler, Maximilian, additional, Mutschlechner, Beatrix, additional, Saely, Christoph, additional, Sprenger, Lukas, additional, Lichtenauer, Michael, additional, Eber, Miriam, additional, Hoppe, Uta, additional, Kolbitsch, Tobias, additional, Jirak, Peter Michael, additional, Mirna, Moritz, additional, Schönbauer, Robert, additional, Bergler-Klein, Jutta, additional, Hengstenberg, Christian, additional, Stojkovic, Stefan, additional, Scherr, Daniel, additional, Manninger-Wünscher, Martin, additional, Rohrer, Ursula, additional, Stühlinger, Markus, additional, Schgoer, Wilfried, additional, Schwarzl, Jana, additional, Pürerfellner, Helmut, additional, Derndorfer, Michael, additional, Ebner, Christian, additional, Eder, Veronika, additional, Kollias, Georgios, additional, Sturmberger, Thomas, additional, Sieghartsleitner, Stefan, additional, Vijgen, Johan, additional, Koopman, Peter, additional, Dujardin, Karl, additional, Anné, Wim, additional, De Ceuninck, Michel, additional, Tavernier, Rene, additional, Duytschaever, Mattias, additional, Knecht, Sébastien, additional, Missault, Luc, additional, Vandekerckhove, Yves, additional, Rossenbacker, Tom, additional, Ector, Bavo, additional, Charlier, Filip, additional, Debruyne, Philippe, additional, Dewilde, Willem, additional, Janssens, Luc, additional, Roosen, John, additional, Vankelecom, Bart, additional, Heidbuchel, Hein, additional, Delesie, Michiel, additional, Vervoort, Gert, additional, Rombouts, Hans, additional, Vanassche, Thomas, additional, Engelen, Matthias, additional, Verhamme, Peter, additional, Willems, Rik, additional, Constance, Christian, additional, Pranno, Nicolas, additional, Cox, Jafna, additional, Bata, Iqbal, additional, Macle, Laurent, additional, Aguilar, Martin, additional, Tourigny, Julia Cadrin, additional, Dubuc, Marc, additional, Dyrda, Katia, additional, Guerra, Peter, additional, Khairy, Paul, additional, Mondésert, Blandine, additional, Rivard, Léna, additional, Roy, Denis, additional, Tadros, Rafik, additional, Talajic, Mario, additional, Thibault, Bernard, additional, Nault, Isabelle, additional, Blier, Louis, additional, Champagne, Jean, additional, Molin, Franck, additional, O'Hara, Gilles, additional, Philippon, François, additional, Plourde, Benoit, additional, Sarrazin, Jean-François, additional, Steinberg, Christian, additional, Coufal, Zdenek, additional, Balazsik, David, additional, Mikulica, Michal, additional, Zapeca, Jakub, additional, Cermak, Ondrej, additional, Drasnar, Tomas, additional, Falc, Matej, additional, Hornof, Josef, additional, Racz, Blazej, additional, Weissova, Danica, additional, Linkova, Hana, additional, Paskova, Eva, additional, Petr, Robert, additional, Sirakova, Andrea, additional, Kettner, Jiri, additional, Benak, Ales, additional, Holek, Martin, additional, Podpera, Ivo, additional, Podperova, Monika, additional, Vancura, Vlastimil, additional, Jandik, Tomas, additional, Smid, Jiri, additional, Dedek, Vratislav, additional, Banik, Jan, additional, Durdil, Vaclav, additional, Hnat, Tomas, additional, Lellouche, Nicolas, additional, Rouffiac, Ségolène, additional, Taldir, Guillaume, additional, Bridonneau, Valentin, additional, Couffon, Philippe, additional, Daudin, Magalie, additional, Hamon, Cécile, additional, Lacaze, Jonathan, additional, Quentin, Anne, additional, Thebault, Christophe, additional, Boiffard, Emmanuel, additional, Billon, Olivier, additional, Miette, Fabien, additional, Pouliquen, Hervé, additional, Turlotte, Guillaume, additional, Gorka, Hervé, additional, Albert, Franck, additional, Bayle, Sandrine, additional, Bensaid, Reda, additional, Dasoveanu, Madalina, additional, Demichili, Thibaud, additional, Dutoiu, Teodora, additional, Khalil, Cliff, additional, Loghin, Caterina, additional, Range, Grégoire, additional, Roussel, Laurent, additional, Socié, Pierre, additional, Thuaire, Christophe, additional, Extramiana, Fabrice, additional, Algalarrondo, Vincent, additional, Boughanmi, Haten, additional, El Mansour, Noreddine, additional, Mohammad, Usman, additional, Sellier, Romain, additional, Elbaz, Meyer, additional, Laperche, Clémence, additional, Maury, Philippe, additional, Kiss, Robert, additional, Borsanyi, Tunde, additional, Gingl, Zoltan, additional, Polgar, Balaza, additional, Benczur, Bela, additional, Bodor, Alexandra, additional, Hepp, Tamas, additional, Malati, Eva, additional, Nagy, Laszlo, additional, Erdei, Norbert, additional, Kapus, Jozsef, additional, Kapus, Katalin, additional, Toth, Brigitta, additional, Matoltsy, Andras, additional, Kiss, Tunde, additional, Merkely, Bela, additional, Herczeg, Szilvia, additional, Kiss, Orsolya, additional, Sallo, Zoltan, additional, Toth, Kalman, additional, Habon, Tamas, additional, Rabai, Miklos, additional, Totsimon, Kinga, additional, Zilahi, Zsolt, additional, Bencze, Gabriella, additional, Santa, Janos, additional, Aradi, Daniel, additional, Kelemen, Barbara, additional, Bolognese, Leonardo, additional, Nesti, Martina, additional, Notarstefano, Pasquale Giovanni, additional, D'Orazio, Simona, additional, Cosmi, Franco, additional, Becattini, Cecilia, additional, Agnelli, Giancarlo, additional, Broccatelli, Belinda, additional, Mosconi, Maria Giulia, additional, Paciaroni, Maurizio, additional, Urbini, Chiara, additional, Parato, Vito Maurizio, additional, Notaristefani, Camilla, additional, Scarano, Michele, additional, Ameri, Pietro, additional, Ghigliotti, Giorgio, additional, Guglielmi, Giulia, additional, Lotti, Roberta, additional, Merlo, Andrea Carlo, additional, Muiesan, Maria Lorenza, additional, Abondio, Andrea, additional, Berasi, Caterina, additional, Mattiuzzo, Elena, additional, Mutti, Claudio, additional, Salvetti, Massimo, additional, Pignatelli, Pasquale, additional, Menichelli, Danilo, additional, Pastori, Daniele, additional, Tamiya, Eiji, additional, Matsumoto, Takahiro, additional, Takabe, Tomosato, additional, Yamamoto, Shoichi, additional, Yamashita, Haruyo, additional, Higashiue, Shinichi, additional, Furuya, Onichi, additional, Hiramatsu, Norihiko, additional, Kasuga, Kensuke, additional, Kojima, Saburo, additional, Komooka, Masatoshi, additional, Kuroyanagi, Satoshi, additional, Matsuura, Makoto, additional, Takemoto, Tetsushi, additional, Yamamoto, Shuji, additional, Saito, Katusmi, additional, Abe, Takuro, additional, Ishida, Issei, additional, Iwanami, Yuji, additional, Kataoka, Shohei, additional, Moriyama, Tetsu, additional, Murohashi, Akira, additional, Sasaki, Akihito, additional, Nakamura, Yuichiro, additional, Ueno, Tetsuya, additional, Shimane, Akira, additional, Hamana, Tomoyo, additional, Ichibori, Hirotoshi, additional, Inoue, Tomohiro, additional, Itoh, Mitsuaki, additional, Iwane, Seigo, additional, Kawai, Hiroya, additional, Kokawa, Tatsuya, additional, Masumoto, Akiko, additional, Matsuo, Koki, additional, Miyata, Taishi, additional, Nakano, Shinsuke, additional, Oishi, Shogo, additional, Onishi, Tetsuari, additional, Sawada, Takahiro, additional, Saito, Takayuki, additional, Shoda, Mitsuhiko, additional, Takahashi, Nobuyuki, additional, Takaya, Tomofumi, additional, Taniguchi, Yasuyo, additional, Tsukamoto, Shota, additional, Tsukishiro, Yasue, additional, Tsukiyama, Yoshiro, additional, Tsunamoto, Hiroshi, additional, Uzu, Kenzo, additional, Yamamoto, Hiroyuki, additional, Yamamoto, Tetsuya, additional, Yokoi, Kiminobu, additional, Yoshida, Chiaki, additional, Watanabe, Nobuhiro, additional, Betsuyaku, Tetsuo, additional, Adachi, Kumiko, additional, Awane, Kouichi, additional, Goto, Daisuke, additional, Sakakibara, Mamoru, additional, Watanabe, Masashi, additional, Ueno, Hideki, additional, Hiroe, Yoshitaka, additional, Matsuo, Koshi, additional, Ayata, Kenji, additional, Fukuda, Ko, additional, Hata, Yoshiki, additional, Hashimoto, Katsushi, additional, Matsumi, Hiroaki, additional, Nikaido, Akira, additional, Okamoto, Shuichi, additional, Sime, Iveta, additional, Stirna, Valters, additional, Reinholde, Ilze, additional, Hansone, Silvija, additional, Kozlovska, Anita, additional, Romanova, Janina, additional, Klincare, Dace, additional, Pontaga, Natalja, additional, Dirmans, Igors, additional, Kalnins, Artis, additional, Upite, Dana, additional, Gersamija, Arcils, additional, Teleznikovs, Arturs, additional, Rozkova, Nadezda, additional, Safro, Jelena, additional, Anguera Camós, Ignasi, additional, Domenico Dallaglio, Paolo, additional, Salguero Bodes, Rafael, additional, Arnbas, Fernando, additional, Borrego, Luis, additional, Marco, Alvaro, additional, Jimenez, Javier Ramos, additional, Gómez-Doblas, Juan José, additional, Pérez Cabeza, Alejandro, additional, Ferreira Gonzålez, Ignacio, additional, Limeres Freire, Javier, additional, Lopez Grau, Merce, additional, Viñolas Prat, Xavier, additional, Moreno Weidmann, Zoraida, additional, Guerra Ramos, Jose Maria, additional, Alonso Martin, Maria Concepcion, additional, Campos Garcia, Bieito, additional, Mogro Carranza, Javier Mauricio, additional, Mendez Zurita, Francisco Javier, additional, Rodriguez Font, Enrique, additional, Gonzales Matos, Carlos Eduardo, additional, García Hernando, Víctor, additional, Lindholm, Carl-Johan, additional, Thulin, Jörgen, additional, Wallén, Håkan, additional, Hagwall, Kristina, additional, Eliasson, Ken, additional, Lundvall, Martin, additional, Olsson, Jens, additional, Kjellman, Björn, additional, Lind, Markus, additional, Johansson, Lars, additional, Svedberg, Niclas, additional, Berglund, Stefan, additional, Söderberg, Julia, additional, Zedigh, Christer, additional, Mooe, Thomas, additional, Axelsson, Mattias, additional, Binsell, Emil, additional, Huber, Daniel, additional, Müller, Christian, additional, Danier, Isabelle, additional, Kühne, Michael, additional, Okamura, Bernhard, additional, Schoepfer, Hadrien, additional, Simmen, Cornelia, additional, Reichlin, Tobias, additional, Chollet, Laurève, additional, Lam, Anna, additional, Wittmer, Severin, additional, Rickli, Hans, additional, Gall, Christian, additional, Hametner, Greta, additional, Intorp, Stephanie, additional, Luescher, Daniel, additional, Haegeli, Laurent, additional, Berg, Jan Christopher, additional, Ebrahimi, Ramin, additional, Auricchio, Angelo, additional, Crljenica, Carmela, additional, Moccetti, Tizziano, additional, Monti, Cristina, additional, Pasotti, Elena, additional, Petrova, Iveta, additional, Rossi, Mariagrazia, additional, Mach, François, additional, Namdar, Mehdi, additional, de Groot, Joris, additional, Proost, Virginnio, additional, Neefs, Joline, additional, Linz, Dominik, additional, van Stipdonk, Twan, additional, den Uijl, Dennis, additional, Alings, Marco, additional, Schaap, Jeroen, additional, Segers, Dolf, additional, Wouters, Noemi, additional, Bartels, Louis, additional, Tieleman, Robert, additional, Pisters, Ron, additional, de Vries, Tim, additional, Selig, Jaap, additional, Kuijper, Aaf, additional, Bot, Pieter, additional, Keijzers, Mitran, additional, Verdel, Gerardus, additional, Tukkie, Raymond, additional, van den Bos, Ewout, additional, Kauer, Floris, additional, Oemrawsingh, Rohit, additional, Stevenhagen, Jeroen, additional, van Es, Jan, additional, Lip, Gregory, additional, Gupta, Dhiraj, additional, Kotalczyk, Agnieszka, additional, Gunstone, Anthony, additional, Brixey, Richard David, additional, Gorog, Diana, additional, Dinarvand, Danial, additional, Gue, Ying, additional, Kanji, Rahim, additional, Memtsas, Vassilios, additional, Senior, Roxy, additional, Bioh, Gabriel, additional, Wong, Yuk-Ki, additional, and Child, Nick, additional

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2022
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97. Impaired biventricular contractile reserve in patients with diastolic dysfunction: insights from exercise stress echocardiography

Author

Claeys, Mathias, primary, Petit, Thibault, additional, La Gerche, Andre, additional, Herbots, Lieven, additional, Claus, Piet, additional, De Bosscher, Ruben, additional, Droogne, Walter, additional, Van Cleemput, Johan, additional, Voigt, Jens Uwe, additional, Delcroix, Marion, additional, Janssens, Stefan, additional, Willems, Rik, additional, Verwerft, Jan, additional, and Claessen, Guido, additional

Published
2022
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98. Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study

Author

Zabel, Markus, Willems, Rik, Lubinski, Andrzej, Bauer, Axel, Brugada, Josep, Conen, David, Flevari, Panagiota, Hasenfuß, Gerd, Svetlosak, Martin, Huikuri, Heikki V, Malik, Marek, Pavlović, Nikola, Schmidt, Georg, Sritharan, Rajevaa, Schlögl, Simon, Szavits-Nossan, Janko, Traykov, Vassil, Tuinenburg, Anton E, Willich, Stefan N, Harden, Markus, Friede, Tim, Svendsen, Jesper Hastrup, Sticherling, Christian, Merkely, Béla, Perge, Peter, Sallo, Zoltan, Szeplaki, Gabor, Szegedi, Nandor, Nagy, Klaudia Vivien, Lüthje, Lars, Sritharan, R, Haarmann, Helge, Bergau, Leonard, Seegers, Joachim, Munoz- Exposito, Pascal, Tichelbäcker, Tobias, Kirova, Aleksandra, Hnatkova, Katerina, Vos, Marc A, Reinhold, Thomas, Vandenberk, Bert, Klinika, Magdalena, Rotkvić, L, Flevari, Panayota, Katsimardos, Andreas, Katsaras, Dimitrios, Hatala, Robert, Kuczejko, Tomasz, Hansen, Jim, Manola, Šime, Vinter, Ozren, Benko, Ivica, Tuinenburg, Anton, Sprenkeler, David, Smoczynska, A, Vos, M A, Meyer-Zürn, Christine, Eick, Christian, Arbelo, Elena, Kaliska, Gabriela, Martinek, Jozef, Dommasch, Michael, Steger, Alexander, Kääb, Stefan, Sinner, Moritz F, Rizas, Konstantinos D, Hamm, Wolfgang, Traykov, V, Cygankiewicz, Iwona, Ptaszyński, Pawel, Kaczmarek, K, Poddebska, I, Iovev, Svetoslav, Novotný, Tomáš, Kozak, Milan, Huikuri, Heikki, Kenttä, Tuomas, Pelli, Ari, Kasprzak, Jaroslaw D, Qavoq, Dariusz, Brusich, Sandro, Avdovic, Ervin, Klasan, Marina, Galuszka, Jan, Taborsky, Milos, Velchev, Vasil, Dissmann, Rüdiger, Shalganov, T, Guzik, P, Krauze, T, Bimmel, Dieter, Lieberz, Christiane, Ludwigsburg, Klinikum, Stefanow, Stefan, Rüb, Norman, Wolpert, Christian, Meier, Lars S, Behrens, Steffen, Jurisic, Zrinka, Braunschweig, Frieder, Blaschke, Florian, Pieske, Burkert, Bakotic, Zoran, Anic, Ante, Weiden, Klinikum, Schwinger, Robert H G, Platonov, Pyotr, Grönefeld, Gerian, Klingenheben, Thomas, and EU-CERT-ICD Study Investigators

Subjects
medicine.medical_specialty, medicine.medical_treatment, Implantable cardioverter-defibrillator, Risk factors, Mortality, Sudden cardiac death, 030204 cardiovascular system & hematology, Ventricular Function, Left, Cohort Studies, EU-CERT-ICD Study Investigators, 03 medical and health sciences, 0302 clinical medicine, Clinical Research, Internal medicine, medicine, Clinical endpoint, Humans, AcademicSubjects/MED00200, Prospective Studies, 030212 general & internal medicine, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, 1102 Cardiorespiratory Medicine and Haematology, Aged, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, Heart Failure, Ejection fraction, Ischemic cardiomyopathy, business.industry, Hazard ratio, Stroke Volume, 1103 Clinical Sciences, Dilated cardiomyopathy, medicine.disease, Confidence interval, Defibrillators, Implantable, 3. Good health, Europe, Primary Prevention, Death, Sudden, Cardiac, Treatment Outcome, Cardiovascular System & Hematology, Implantable cardioverter-defibrillator, Risk factors, Mortality, Sudden cardiac death, Cardiology and Cardiovascular Medicine, business, Cohort study
Abstract

Aims The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed to assess current clinical effectiveness of primary prevention ICD therapy. Methods and results We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and guideline indications for prophylactic ICD implantation. Primary endpoint was all-cause mortality. Clinical characteristics, medications, resting, and 12-lead Holter electrocardiograms (ECGs) were documented at enrolment baseline. Baseline and follow-up (FU) data from 2247 patients were analysable, 1516 patients before first ICD implantation (ICD group) and 731 patients without ICD serving as controls. Multivariable models and propensity scoring for adjustment were used to compare the two groups for mortality. During mean FU of 2.4 ± 1.1 years, 342 deaths occurred (6.3%/years annualized mortality, 5.6%/years in the ICD group vs. 9.2%/years in controls), favouring ICD treatment [unadjusted hazard ratio (HR) 0.682, 95% confidence interval (CI) 0.537–0.865, P = 0.0016]. Multivariable mortality predictors included age, left ventricular ejection fraction (LVEF), New York Heart Association class Conclusion In contemporary ICM/DCM patients (LVEF ≤35%, narrow QRS), primary prophylactic ICD treatment was associated with a 27% lower mortality after adjustment. There appear to be patients with less survival advantage, such as older patients or diabetics.

Published
2020

99. QRS micro-fragmentation as a mortality predictor

Author

Hnatkova, Katerina, primary, Andršová, Irena, additional, Novotný, Tomáš, additional, Britton, Annie, additional, Shipley, Martin, additional, Vandenberk, Bert, additional, Sprenkeler, David J, additional, Junttila, Juhani, additional, Reichlin, Tobias, additional, Schlögl, Simon, additional, Vos, Marc A, additional, Friede, Tim, additional, Bauer, Axel, additional, Huikuri, Heikki V, additional, Willems, Rik, additional, Schmidt, Georg, additional, Franz, Michael R, additional, Sticherling, Christian, additional, Zabel, Markus, additional, and Malik, Marek, additional

Published
2022
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