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54. The Future of Natural Resources Law.

Author

Mergen, Andy, Doremus, Holly, Wilkinson, Charles, and Owen, Dave

Abstract

The article focuses on the panel discussion moderated by Andy Mergen, featuring environmental regulation professor Holly Doremus and law professors Charles Wilkinson and Dave Owen about the future of natural resources law of the U.S. Topics include Clean Water Act (CWA) and its relevance to the work of the U.S. Department of Justice (DOJ), role of place of Indian tribes in the future of natural resources law and policy, and the debate between prescriptive regulatory and market-based approaches.

Published
2017

58. They had nothing.

Author

Wilkinson, Charles

Abstract

The article discusses issues concerning the 1974 Boldt decision in the U.S. in which the court affirmed fishing rights of native American Indian tribes.

Published
2015

67. Index.

Author

Scanlon, Peter H., Wilkinson, Charles P., Aldington, Stephen J., and Matthews, David R.

Published
2009
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80. Diabetes.

Author

Scanlon, Peter H., Wilkinson, Charles P., Aldington, Stephen J., and Matthews, David R.

Published
2009
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81. Front Matter.

Author

Scanlon, Peter H., Wilkinson, Charles P., Aldington, Stephen J., and Matthews, David R.

Published
2009
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85. The Endophthalmitis Vitrectomy Study

Author

Johnson, Mark W., primary, Doft, Bernard H., additional, Kelsey, Sheryl F., additional, Barza, Michael, additional, Wilson, Louis A., additional, Barr, Charles C., additional, Wisniewski, Stephen R., additional, Vine, Andrew K., additional, Blodi, Barbara A., additional, Elner, Susan G., additional, Johnson, Mark W., additional, Jessup, Laurie M., additional, Khanderia, Sharad, additional, Pierson, Carl L., additional, Willis, Julie, additional, McIver, Frances, additional, Stanley, Sally, additional, Sneed, Scott R., additional, Capone, Antonio, additional, Aaberg, Thomas M., additional, Lim, Jennifer I., additional, Sternberg, Paul, additional, Coffman, Diana S., additional, Moore, Cameile N., additional, Gardner, Susanne K., additional, Nolte, Frederick S., additional, Fremstad, Ann, additional, Gibbs, Deborah, additional, Gilman, James, additional, Swords, Ray, additional, Aguilar, H.Edith, additional, Meredith, Travis A., additional, Lakhanpal, Vinod, additional, Christian, Faith D., additional, Hood, A., additional, Schwalbe, Richard S., additional, Billings, Emery E., additional, Buie, William, additional, Mallonee, James J., additional, Millar, Mary Ann, additional, Verbeek, Sharon, additional, Campochiaro, Peter A., additional, Palardy, Carol B., additional, Reynolds, Lois, additional, Dick, James D., additional, Cain, Dennis, additional, D'Amico, Donald J., additional, Frederick, Albert R., additional, Morley, Michael G., additional, Pesavento, Richard D., additional, Puliafito, Carmen A., additional, Topping, Trexler M., additional, Finn, Susan M., additional, Raymond, Laura A., additional, Baker, Ann Sullivan, additional, Paton, Barbara, additional, Evans, Claudia, additional, Napoli, Jeffrey, additional, Kierman, Christine, additional, Makris, Kathryn, additional, McInnes, Tom, additional, Reidy, Wini T., additional, White, Ruth, additional, Garfinkel, Richard A., additional, Pilkerton, A.Raymond, additional, Frantz, Robert A., additional, Abernathy, Gill B., additional, Barbaccia, Jay G., additional, Ensey, H.Russell, additional, Ormes, Carol A., additional, Park, Choong H., additional, Caplan, Joel, additional, Russell, Kathryn, additional, Toma, Robert, additional, Packo, Kirk H., additional, de Bustros, Serge, additional, Flood, Timothy P., additional, Glazer, Louis, additional, DeAlba, Maggie, additional, Evanich, Evangeline, additional, Montwill, Michael A., additional, Rothman, Jeri J., additional, Ruderman, Gail, additional, Beard, Melodie, additional, Landau, William, additional, Shen, Min H., additional, Gordon, Martha, additional, Graff, Sharon, additional, Kwiatkowski, Kathy, additional, Pappas, Loreen, additional, Bryant, Douglas, additional, Doherty, Don, additional, Morini, Frank, additional, Arredondo, Linda, additional, Garretson, Bruce R., additional, Gerena, Carlos, additional, Hunt, Maureen, additional, Kinnaird, Sharon M., additional, Neri, Toni, additional, Rice, Thomas A., additional, Novak, Michael A., additional, Rowe, Pamela S., additional, Jamieson, Scott, additional, Newberry, Deborah, additional, Rech, Glenn R., additional, Dul, Michael J., additional, Kinser, Livia, additional, Strozewski, Krystyna, additional, Clark-Rath, Susan, additional, DeLisio, Marty, additional, Dempsey, David L., additional, Kukula, Donna, additional, Pinter-Smith, Anne, additional, Smith-Brewer, Sheila, additional, Ludwig, Tracey, additional, Chambers, Robert B., additional, Davidorf, Frederick H., additional, Taylor, Cindy S., additional, Hale, Karen N., additional, Buesching, William J., additional, Chaudhuri, Chhanda, additional, Cover, Nanci J., additional, Shortlidge, Gail R., additional, Keating, Michael J., additional, Savage, Scott J., additional, Andrzejewska, Paula, additional, Cometet, Susan, additional, Milliron, Jill D., additional, Richmond, Rob, additional, Schneider, Lori, additional, Weisenberger, Debra, additional, Cantrill, Herbert L., additional, Ramsay, Robert C., additional, Brallier, Amy B., additional, Johnson, Timothy P., additional, Rossing, Edith E., additional, Knauth, Kathleen A., additional, Monahan, Martha M., additional, Oestreich, Neal W., additional, Clark, Kenneth F., additional, Glennen, Anita M., additional, Yarian, David L., additional, Green, Stuart N., additional, Leff, Steven R., additional, Masciulli, Leo, additional, Lucido, Margaret M., additional, Ludwig, Edward J., additional, Marano, Charlotte L., additional, Peters, Linda, additional, Joho, Kim, additional, Volkert, Doris C., additional, Andersen, Finn, additional, Coffey, Donna, additional, Schlosser, Alex, additional, Honeywell, Ann, additional, Mames, Robert N., additional, Driebe, William T., additional, Stern, George A., additional, Francis, Amye, additional, Zam, Z.Suzanne, additional, Cooper, Rhonda, additional, Gaskins, Darla, additional, Shamis, Diana J., additional, Willingham, Melinda, additional, Barker, Kay, additional, Rosa, Harry, additional, Friedman, Scott M., additional, Gardner, Thomas W., additional, Blankenship, George W., additional, Coyle, Carole J., additional, Bero, Christopher J., additional, Halas, Cindy, additional, Schick, Suzanne, additional, Walker, Jean, additional, Cunningham, Denise, additional, Lambert, H.Michael, additional, Clogston, Pamela S., additional, Frady, Pamela M., additional, Gardner, S.Neal, additional, Osato, Michael S., additional, Carr, Louise, additional, Shigley, James, additional, Lopez, Pedro F., additional, Chong, Lawrence P., additional, Frambach, Donald A., additional, CisnerosMargaret^Padilla, Lupe, additional, Yee, Edmond Ming, additional, Nakamura, Tamako, additional, Walonker, A.Frances, additional, Morales, Ronald, additional, Nichols, Tracy, additional, Huete, Maria E., additional, Liggett, Peter E., additional, Ober, Richard R., additional, Quillen-Thomas, Beth, additional, Williams, Mark, additional, Bloom, Steven M., additional, Greene, Pamela J., additional, Whittington, Greg K., additional, Martin, Mark E., additional, Watson, Glen, additional, Jenkins-Curry, Betty, additional, Gilkey, Leigh A., additional, Huelsman, Steven, additional, Han, Dennis P., additional, Burton, Thomas C., additional, Mieler, William F., additional, Pulido, Jose S., additional, Reeser, Frederick H., additional, Newman, Janet L., additional, Werner, Kathy A., additional, Pisarzewicz, Paul J., additional, Reinerio, Nina A., additional, Walloch, Mary Lee K., additional, Wilmer, Zuzana, additional, Laabs, Jan, additional, Picchiottino, Ruth, additional, Phillips, Jim, additional, Wipplinger, Walter, additional, Abrams, Gary W., additional, Jurkiewicz, Dale T., additional, Leet, Margaret L., additional, Mandel, Paul, additional, Metzger, Kim, additional, Suchla, Lori, additional, Zarling, Denise, additional, Balles, Mark W., additional, Ryan, Edwin H., additional, Knobloch, William H., additional, Cook, Sally M., additional, Luke, Darlette G., additional, Ferrieri, Patricia, additional, Schiminsky, Norynne M., additional, Genia, Anne, additional, Philiph, David A., additional, Stinson, Elizabeth K., additional, Wright, Linda M., additional, McMichael, William C., additional, Mielke, Sandy J., additional, Ponwith, Lisa J., additional, Pavan, Peter Reed, additional, Pautler, Scott E., additional, Coats, Marion L., additional, Kirk, Nancy M., additional, Millard, Sharon M., additional, Castellano, Frank C., additional, Edwards, Charlotte R., additional, Marquardt, Angela, additional, McCormack, Amy J., additional, McCormick, Michael T., additional, Renshaw, Bernard, additional, Restuccia, Angela, additional, Campbell, Monica, additional, Christopher, Nell, additional, Garrett, L.Scott, additional, Halkias, Demetrios G., additional, Hothersall, Kim, additional, Mickler, Karen, additional, Minnick, Thomas S., additional, Burr, Cheryl, additional, Saxon, Wyatt, additional, Arcacha, Miguel A., additional, Carlton, Steve, additional, Edison, Sonya K., additional, Mallis, Marc J., additional, Sayers, Tamre L., additional, Sudds, Thomas W., additional, Tiberia, Robert J., additional, Wolabaugh, Sherry, additional, Bradford, Reagan H., additional, Parke, David W., additional, Wolf, Thomas C., additional, Shofner, Janie M., additional, Tobey, Lee E., additional, Jensen, Harold G., additional, Sanchez, Dinah, additional, Shofner, Janie, additional, Burris, Russell, additional, Drake, Kellie K., additional, Grissom, Kay R., additional, Rowsey, J.James, additional, Wilkinson, Charles P., additional, Brown, Gary C., additional, Benson, William E., additional, Federman, Jay L., additional, Lucier, Alfred C., additional, Maguire, Joseph I., additional, Sarin, Lov K., additional, Shakin, Eric P., additional, Sivalingam, Arunan, additional, Tasman, William, additional, Vander, James F., additional, Ward, Nancy, additional, Weisbecker, Clement A., additional, Agnew, Caroline L., additional, Lambert, Richard, additional, Torner, Terrance, additional, Carlson, Kathy, additional, Franchine, Gerrie, additional, Serfass, Michelle S., additional, Bergren, Robert L., additional, Lobes, Louis A., additional, Olsen, Karl R., additional, Rinkoff, Jeffrey S., additional, Metz, Donna J., additional, Leonard, Margaret N., additional, Karenchak, Lisa M., additional, Kowalski, Regis P., additional, Wellman, Lynn A., additional, Wilcox, Linda A., additional, Campbell, Alan F., additional, Steinberg, David R., additional, Vagstad, Gary L., additional, Flook, Kimberly A., additional, Good, Mary M., additional, Keenen, Beverly J., additional, Mellinger, Kim A., additional, Margherio, Raymond R., additional, Cox, Morton S., additional, Murphy, Patrick L., additional, Trese, Michael T., additional, Werner, Jane C., additional, Williams, George A., additional, Manatrey, Patricia E., additional, Prote, Janet L., additional, Lucarotti, Richard, additional, Martin, Susan, additional, Band, Jeff, additional, Bostic, Grace, additional, Gumming, Kristi, additional, Mitchell, Beth, additional, Regan, Virginia S., additional, Bridges, Craig, additional, Cox, Sam, additional, Houston, Gary, additional, Johnson, John, additional, Streasik, Pat, additional, Wood, Betty, additional, Blumenkranz, Mark S., additional, Cayo, Lisa, additional, Kaye, Virginia, additional, Valenzuela, Carmen Luz, additional, Orgel, Ira K., additional, Poliner, Lon S., additional, Tornambe, Paul E., additional, Cannon, Sarah V., additional, Nielsen, Janet L., additional, Carlson, Anne, additional, Chan, Pauline, additional, Drake, Lynne, additional, Grim, Martha, additional, Peterson, Corky, additional, Borg, Lynn A., additional, Gillyatt, Joann, additional, Beyer, Conny, additional, Hammer, Mark E., additional, Grizzard, W.Sanderson, additional, Shannon, Theresa L., additional, Traynom, Janet R., additional, Collado, Melinda J., additional, McManus, Dennis W., additional, Sweeney, Daniel E., additional, Adams, Donald H., additional, Watson, Thomas T., additional, Antworth, Michael V., additional, Araos, Johanna Glacy, additional, Greenwald, Mark A., additional, Habib, Mohsen, additional, Myers, Sandra K., additional, Ockers, Karen M., additional, Thibodeau, Judy-Ann, additional, Watkins, Brett, additional, Nelsen, Philip T., additional, Rosenthal, J.Gregory, additional, Mintz, Fay V., additional, Biedenbach, Michael, additional, Leonardy, Nicholas J., additional, Lawniczak, Sue M., additional, Bork, Chuck, additional, Hageage, George, additional, Hunter, Evelyn B., additional, Marshall, MarLynn J., additional, Roman, Patricia, additional, Hill, Rick, additional, Hofbauer, Thomas, additional, Lemanowicz, Jack, additional, Cupples, Howard P., additional, Guzman, Gladys I., additional, Brodeur, Richard J., additional, Yee, Donald, additional, Delaha, Edward C., additional, Geyer, Stanley L., additional, Slovis, Stacey, additional, Shields, William J., additional, Lauber, Susan, additional, Michelitsch, Karl, additional, Kassoff, Aaron, additional, Watling, Sharon, additional, Buehler, JoAnne C., additional, McVay, Jeffrey, additional, Podobinski, Gale K., additional, Sillett, Robert L., additional, Groer, Shirley, additional, Avery, Brian, additional, Belle, Steven H., additional, Boles, James, additional, Henry, Linda, additional, Shema, Sarah J., additional, Titus-Emstoff, Linda, additional, Davis, Matthew, additional, Magli, Yvonne L., additional, Hubbard, Larry, additional, Thomas, Suzanne, additional, Everett, Donald F., additional, Mowery, Richard, additional, Everett, Donald, additional, Davis, Kathryn, additional, Azen, Stanley, additional, Covey, Preston, additional, McCuen, Brooks, additional, Packer, Andrew, additional, and Robin, Jeffrey, additional

Published
1997
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86. Retinal Detachment

Author

Michels, Ronald G., primary, Wilkinson, Charles P., additional, Rice, Thomas A., additional, and Weinberg, Aaron B., additional

Published
1991
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88. In Patients With Heart Failure Elevated Soluble TNF-Receptor 1 Is Associated With Higher Risk of Depression.

Author

Moorman, Alec J., Mozaffarian, Dariush, Wilkinson, Charles W., Lawler, Richard L., McDonald, George B., Crane, Barbara A., Spertus, John A., Russo, Joan E., Stempien-Otero, April S., Sullivan, Mark D., and Levy, Wayne C.

Abstract

Abstract: Background: Pro-inflammatory cytokines may contribute to the development and progression of heart failure (HF) and are also implicated in depressive disorders. In this cross-sectional study, we investigated whether systemic inflammation, as assessed by circulating levels of inflammatory cytokines, was associated with comorbid depression in patients with heart failure. Methods and Results: Baseline clinical variables, depression status, and inflammatory marker levels were measured in 129 ambulatory HF patients. We hypothesized that pro-inflammatory cytokines, specifically tumor necrosis factor (TNF)-α, interleukin (IL)-1, and IL-6, would be elevated in HF patients with comorbid depression. In unadjusted analyses, levels of soluble TNF-α receptor1 (sTNFr1) were significantly higher among depressed (1.6 ng/mL), compared with nondepressed (1.1 ng/mL), HF patients (P = .01). After multivariate adjustment, compared with patients in the lowest quartile of sTNFr1 levels, those in the highest quartile had an adjusted near 5-fold higher risk of depression (OR 4.6, 95% CI 1.2–17.3; P for trend .008). The subgroup of patients on antidepressants but not currently depressed had a trend toward higher levels of sTNFr1, suggesting that antidepressants may not lower cytokine levels even when adequately treating depressive symptoms. IL-1β and IL-6 levels were not significantly different among depressed versus nondepressed HF patients. Conclusions: In this cross-sectional analysis, HF patients with comorbid depression, compared with nondepressed HF patients, had higher levels of sTNFr1 and trend toward higher levels of sTNFr1 even when adequately treated for depression. [Copyright &y& Elsevier]

Published
2007
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89. NARF observes 35 years of "Fighting For Justice.".

Author

Wilkinson, Charles

Abstract

Features the Native American Rights Fund (NARF) which has brought highly ethical legal representation to tribes. Historical background and development of the NARF; Mission of the NARF; History of modern Indian law and policy.

Published
2005

91. Land Use, Science, and Spirituality: The Search for a True and Lasting Relationship with the Land.

Author

Wilkinson, Charles

Abstract

The article describes the process of reclaiming lands in the western U.S. in the face of rapid development. Environmental lobbyists are credited with successfully educating the public about the science of ecology. Public policy toward federal, state, and tribal lands is reviewed. The article also discusses land trusts, and river policy, while emphasizing a shift away from land management planning on the federal level to planning on the community level. The author urges readers to learn from the spirituality of the American Indian and his concomitant reverence for the land.

Published
2000

92. Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides: Randomized Clinical Trial

Author

Hanson, Angela J., Bayer-Carter, Jennifer L., Green, Pattie S., Montine, Thomas J., Wilkinson, Charles W., Baker, Laura D., Watson, G. Stennis, Bonner, Laura M., Callaghan, Maureen, Leverenz, James B., Tsai, Elaine, Postupna, Nadia, Zhang, Jing, Lampe, Johanna, and Craft, Suzanne

Abstract

IMPORTANCE Sporadic Alzheimer disease (AD) is caused in part by decreased clearance of the β-amyloid (Aβ) peptide breakdown products. Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Aβ, and LD Aβ peptides are more toxic to neurons. However, not much is known about the lipid states of these proteins in human cerebrospinal fluid. OBJECTIVE To characterize the lipidation states of Aβ peptides and apolipoprotein E in the cerebrospinal fluid in adults with respect to cognitive diagnosis and APOE ε4 allele carrier status and after a dietary intervention. DESIGN Randomized clinical trial. SETTING Veterans Affairs Medical Center clinical research unit. PARTICIPANTS Twenty older adults with normal cognition (mean [SD] age, 69 [7] years) and 27 with amnestic mild cognitive impairment (67 [6] years). INTERVENTIONS Randomization to a diet high in saturated fat content and with a high glycemic index (High diet; 45% of energy from fat [>25% saturated fat], 35%-40% from carbohydrates with a mean glycemic index >70, and 15%-20% from protein) or a diet low in saturated fat content and with a low glycemic index (Low diet; 25% of energy from fat [<7% saturated fat], 55%-60% from carbohydrates with a mean glycemic index <55, and 15%-20% from protein). MAIN OUTCOMES AND MEASURES Lipid-depleted Aβ42 and Aβ40 and apolipoprotein E in cerebrospinal fluid. RESULTS Baseline levels of LD Aβ were greater for adults with mild cognitive impairment compared with adults with normal cognition (LD Aβ42, P = .05; LD Aβ40, P = .01). These findings were magnified in adults with mild cognitive impairment and the ε4 allele, who had higher LD apolipoprotein E levels irrespective of cognitive diagnosis (P < .001). The Low diet tended to decrease LD Aβ levels, whereas the High diet increased these fractions (LD Aβ42, P = .01; LD Aβ40, P = .15). Changes in LD Aβ levels with the Low diet negatively correlated with changes in cerebrospinal fluid levels of insulin (LD Aβ42 and insulin, r = −0.68 [P = .01]; LD Aβ40 and insulin, r = −0.78 [P = .002]). CONCLUSIONS AND RELEVANCE The lipidation states of apolipoproteins and Aβ peptides in the brain differ depending on APOE genotype and cognitive diagnosis. Concentrations can be modulated by diet. These findings may provide insight into the mechanisms through which apolipoprotein E4 and unhealthy diets impart risk for developing AD.

Published
2013
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93. Glossary.

Author

Scanlon, Peter H., Wilkinson, Charles P., Aldington, Stephen J., and Matthews, David R.

Published
2009
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94. Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive ImpairmentDiet Intervention and CSF Biomarkers in aMCI

Author

Bayer-Carter, Jennifer L., Green, Pattie S., Montine, Thomas J., VanFossen, Brian, Baker, Laura D., Watson, G. Stennis, Bonner, Laura M., Callaghan, Maureen, Leverenz, James B., Walter, Brooke K., Tsai, Elaine, Plymate, Stephen R., Postupna, Nadia, Wilkinson, Charles W., Zhang, Jing, Lampe, Johanna, Kahn, Steven E., and Craft, Suzanne

Abstract

OBJECTIVE To compare the effects of a 4-week high–saturated fat/high–glycemic index (HIGH) diet with a low–saturated fat/low–glycemic index (LOW) diet on insulin and lipid metabolism, cerebrospinal fluid (CSF) markers of Alzheimer disease, and cognition for healthy adults and adults with amnestic mild cognitive impairment (aMCI). DESIGN Randomized controlled trial. SETTING Veterans Affairs Medical Center clinical research unit. PARTICIPANTS Forty-nine older adults (20 healthy adults with a mean [SD] age of 69.3 [7.4] years and 29 adults with aMCI with a mean [SD] age of 67.6 [6.8] years). INTERVENTION Participants received the HIGH diet (fat, 45% [saturated fat, > 25%]; carbohydrates, 35%-40% [glycemic index, > 70]; and protein, 15%-20%) or the LOW diet (fat, 25%; [saturated fat, < 7%]; carbohydrates, 55%-60% [glycemic index, < 55]; and protein, 15%-20%) for 4 weeks. Cognitive tests, an oral glucose tolerance test, and lumbar puncture were conducted at baseline and during the fourth week of the diet. MAIN OUTCOME MEASURES The CSF concentrations of β-amyloid (Aβ42 and Aβ40), tau protein, insulin, F2-isoprostanes, and apolipoprotein E, plasma lipids and insulin, and measures of cognition. RESULTS For the aMCI group, the LOW diet increased CSF Aβ42 concentrations, contrary to the pathologic pattern of lowered CSF Aβ42 typically observed in Alzheimer disease. The LOW diet had the opposite effect for healthy adults, ie, decreasing CSF Aβ42, whereas the HIGH diet increased CSF Aβ42. The CSF apolipoprotein E concentration was increased by the LOW diet and decreased by the HIGH diet for both groups. For the aMCI group, the CSF insulin concentration increased with the LOW diet, but the HIGH diet lowered the CSF insulin concentration for healthy adults. The HIGH diet increased and the LOW diet decreased plasma lipids, insulin, and CSF F2-isoprostane concentrations. Delayed visual memory improved for both groups after completion of 4 weeks of the LOW diet. CONCLUSION Our results suggest that diet may be a powerful environmental factor that modulates Alzheimer disease risk through its effects on central nervous system concentrations of Aβ42, lipoproteins, oxidative stress, and insulin.Arch Neurol. 2011;68(6):743-752--

Published
2011
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95. Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled TrialTrial of Aerobic Exercise for Mild Cognitive Impairment

Author

Baker, Laura D., Frank, Laura L., Foster-Schubert, Karen, Green, Pattie S., Wilkinson, Charles W., McTiernan, Anne, Plymate, Stephen R., Fishel, Mark A., Watson, G. Stennis, Cholerton, Brenna A., Duncan, Glen E., Mehta, Pankaj D., and Craft, Suzanne

Abstract

OBJECTIVES To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response. DESIGN Six-month, randomized, controlled, clinical trial. SETTING Veterans Affairs Puget Sound Health Care System clinical research unit. PARTICIPANTS Thirty-three adults (17 women) with amnestic mild cognitive impairment ranging in age from 55 to 85 years (mean age, 70 years). INTERVENTION Participants were randomized either to a high-intensity aerobic exercise or stretching control group. The aerobic group exercised under the supervision of a fitness trainer at 75% to 85% of heart rate reserve for 45 to 60 min/d, 4 d/wk for 6 months. The control group carried out supervised stretching activities according to the same schedule but maintained their heart rate at or below 50% of their heart rate reserve. Before and after the study, glucometabolic and treadmill tests were performed and fat distribution was assessed using dual-energy x-ray absorptiometry. At baseline, month 3, and month 6, blood was collected for assay and cognitive tests were administered. MAIN OUTCOME MEASURES Performance measures on Symbol-Digit Modalities, Verbal Fluency, Stroop, Trails B, Task Switching, Story Recall, and List Learning. Fasting plasma levels of insulin, cortisol, brain-derived neurotrophic factor, insulinlike growth factor-I, and β-amyloids 40 and 42. RESULTS Six months of high-intensity aerobic exercise had sex-specific effects on cognition, glucose metabolism, and hypothalamic-pituitary-adrenal axis and trophic activity despite comparable gains in cardiorespiratory fitness and body fat reduction. For women, aerobic exercise improved performance on multiple tests of executive function, increased glucose disposal during the metabolic clamp, and reduced fasting plasma levels of insulin, cortisol, and brain-derived neurotrophic factor. For men, aerobic exercise increased plasma levels of insulinlike growth factor I and had a favorable effect only on Trails B performance. CONCLUSIONS This study provides support, using rigorous controlled methodology, for a potent nonpharmacologic intervention that improves executive control processes for older women at high risk of cognitive decline. Moreover, our results suggest that a sex bias in cognitive response may relate to sex-based differences in glucometabolic and hypothalamic-pituitary-adrenal axis responses to aerobic exercise.Arch Neurol. 2010;67(1):71-79--

Published
2010
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96. Return of the Canoe Journey.

Author

Wilkinson, Charles

Abstract

Presents an excerpt from the book "Blood Struggle: The Rise of Modern Indian Nations," by Charles Wilkinson.

Published
2005

97. Chronic Daily Ethanol and Withdrawal: 3. Forebrain Pro‐Opiomelanocortin Gene Expression and Implications for Dependence, Relapse, and Deprivation Effect

Author

Rasmussen, Dennis D., Boldt, Brian M., Wilkinson, Charles W., and Mitton, Dennis R.

Abstract

Background: Although forebrain pro‐opiomelanocortin (POMC)–producing neurons seem to mediate or modulate many responses to ethanol consumption, changes in activity of this opiomelanocortinergic system in response to chronic ethanol consumption, withdrawal, and subsequent abstinence remain unresolved.

Published
2002
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98. Chronic Daily Ethanol and Withdrawal: 1. Long‐Term Changes in the Hypothalamo‐Pituitary‐Adrenal Axis

Author

Rasmussen, Dennis D., Boldt, Brian M., Bryant, Carrie A., Mitton, Dennis R., Larsen, Shana A., and Wilkinson, Charles W.

Abstract

Background: Hypothalamo‐pituitary‐adrenal (HPA) function has been demonstrated to be compromised for weeks and even months after alcoholics cease ethanol consumption. Because nonalcoholic subjects with family history‐associated increased risk for alcoholism also exhibit compromised HPA function, it is not clear whether defects in the HPA axis of abstinent alcoholics reflect a preexisting condition that may be responsible for increased risk for alcohol abuse versus a persisting adaptational change in response to prolonged alcohol abuse. Consequently, we investigated whether chronic daily ethanol consumption and withdrawal by male Sprague Dawley® rats would induce persistent HPA changes consistent with those demonstrated in abstinent alcoholics.

Published
2000
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99. THE OLD MAN & THE ORCHID.

Author

Wilkinson, Charles

Subjects
OLD Man & the Orchid, The (Poem), WILKINSON, Charles
Published
2021

100. Sustaining the People's Lands -- Recommendations for Stewardship of the National Forests and Grasslands into the Next Century

Author

Johnson, K. Norman, Agee, James, Beschta, Robert, Dale, Virginia, Hardesty, Linda, Long, James, Nielsen, Larry, Noon, Barry, Sedjo, Roger, Shannon, Margaret, Trosper, Ronald, Wilkinson, Charles, and Wondolleck, Julia

Abstract

In December 1997, Secretary of Agriculture Dan Glickman convened an interdisciplinary committee of 13 scientists to provide scientific and technical advice on the Forest Service's land and resource management planning process. The committee was asked to recommend how best to accomplish resource planning within the existing environmental laws and statutory mission of the Forest Service; to provide technical advice on planning and provide material for the agency to consider in revising planning regulations; to recommend improvements in coordination with other federal agencies, state and local government agencies, and tribal governments; and to suggest a new planning framework that could last a generation. The committee took field trips and met in cities and towns around the country to hear from Forest Service employees, representatives of tribes, state and local governments, related federal natural resource agencies, and members of the public. Drawing on many of the approaches and improvements to planning it observed, the committee has made its recommendations.

Published
1999
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